Hub : Genes

PPP1CC

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0208	0.0085	3.8e-06	0.016	0.017	0.018	0.018	0.015	2.8e-06	2.8e-06	1.1e-06	1.2e-06	9.6e-06
2	TCGA	Cervical Squamous Cell Carcinoma	0.0480	0.0310	7.3e-03	0.020	0.039	0.022	NA	0.016	3.6e-02	5.2e-03	2.7e-02	NA	5.1e-02
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0525	0.0286	4.9e-03	0.012	0.020	0.017	NA	0.007	1.4e-02	2.1e-03	4.7e-03	NA	5.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	2.5	0.1	0.6	-1.6
Bipolar Disorder or Schizophrenia	2.4	5.9	9.4	-2.2	-3.1	-1.8
Depressed Affect (Nagel 2018)	0.7	1.6	3.2	-1.8	-0.6	1.1
Depression (Nagel 2018)	1.3	2.0	3.5	1.5	1.9	-0.6
Intelligence (Savage-Jansen 2018)	4.3	13.1	17.5	4.2	4.2	-2.1
Neuroticism (Nagel 2018)	0.6	1.5	3.4	-1.9	-0.7	0.8
Schizophrenia (2018)	4.7	9.8	19.5	-3.0	-4.4	-1.0
Schizophrenia vs Biploar Disorder	2.2	2.9	7.0	-0.4	-2.7	-1.2
Worry (Nagel 2018)	2.0	4.3	6.4	-2.4	-2.5	0.8
Alzheimer’s Disease (in mother)	2.0	2.3	3.1	-1.8	-1.2	1.5
Alzheimer’s Disease (in father)	0.2	0.3	0.4	0.3	0.6	-0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	2.1	-1.5	-0.7	0.5
Crohns Disease (2017)	2.5	5.5	8.1	2.8	2.3	-1.7
Irritable Bowel Disease (IBD)	1.1	2.7	4.2	2.0	0.8	-1.8
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.0	-0.9	-0.7
Major Depression (MDD)	0.5	0.6	1.0	-1.0	-0.7	0.6
Reaction Time	0.2	0.4	0.8	0.5	-0.3	-0.9
Verbal and Numeric Reasoning (VNR)	6.2	14.9	19.5	4.4	4.3	-2.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.5	0.7	1.1	-1.1	-0.7	0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.0	2.9	4.3	2.1	1.8	-1.1
Bipolar Disorder (2011)	0.7	0.7	1.6	-1.3	-0.7	0.2
Body Mass Index (BMI) (2010)	0.6	0.9	2.1	-0.7	1.4	0.3
Coronary Artery Disease (CAD)	2.6	3.2	8.1	-1.0	-2.9	-0.5
Crohns Disease (2012)	2.6	4.2	8.0	2.8	1.7	-1.2
Mean Putamen Volume	0.5	0.6	1.1	0.0	-0.9	-1.0
Fasting Glucose	0.1	0.1	0.3	-0.2	0.1	-0.6
HbA1C	0.4	0.4	0.7	-0.9	-0.7	0.1
HDL Cholesterol	1.4	2.4	3.2	1.8	1.1	-1.6
LDL Cholesterol	0.7	1.1	3.0	-1.7	-0.2	0.6
Lupus	2.8	4.3	7.5	-2.2	-2.7	0.5
Neuroticism (2016)	6.9	10.0	15.5	-3.9	-2.3	3.0
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.7	0.8	0.0
Rheumatoid Arthritis	0.5	0.7	0.8	0.9	0.8	0.7
Schizophrenia (2014)	4.4	9.8	19.6	-2.5	-4.4	-1.9
Triglycerides	0.1	0.2	0.4	0.2	0.2	-0.7
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.9	0.7	1.4	-1.2
Ulcerative Colitis	0.3	0.4	0.5	0.6	-0.7	-0.7
Blood Eosinophil Count	1.7	12.8	27.2	5.2	-3.4	0.0
Blood Platelet Count	2.9	33.1	95.6	9.8	1.9	-0.4
Blood Red Count	0.4	3.7	9.1	1.4	-3.0	-0.3
Blood White Count	0.7	5.1	5.9	2.1	-2.2	2.4
Heel T-Score	0.8	6.3	11.3	3.4	0.8	-2.6
BMI	0.6	3.6	9.1	1.3	3.0	-0.3
Height	0.3	6.6	14.4	-3.8	-2.1	0.9
Waist Hip Ratio (WHR)	0.5	2.3	5.1	-0.8	-2.2	-1.1
Systolic Blood Pressure	1.7	8.7	11.8	1.8	-3.3	-3.4
Smoking Status	0.1	0.3	0.4	0.6	-0.5	0.6
Allergy or Eczema	0.4	1.0	2.7	0.1	0.6	-1.6
Cardiovascular Disease	1.2	4.1	8.2	1.6	-1.3	-2.9
Hypothyroidism (self reported)	1.9	4.3	11.4	-0.2	-3.4	1.2
Respiratory disease	0.9	2.1	5.4	0.8	0.5	-2.3
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.5	0.1	-0.1	-1.6
Lung FEV1/FVC ratio	0.4	2.0	5.6	-0.1	2.4	0.5
Lung FVC	1.0	5.1	6.1	2.2	2.1	2.5
Neuroticism	0.6	1.4	3.4	-1.8	-0.8	0.4
Chronotype (morning person)	1.0	2.3	3.5	-0.9	-1.9	1.7
Hair Pigment	0.2	4.7	9.7	-3.1	-1.8	1.1
Tanning	0.5	5.8	10.1	2.6	3.2	-0.6
Hand grip strength (left)	0.3	0.8	1.1	-0.8	-0.7	1.0
Number of treatments/medications taken	0.6	1.1	1.7	1.3	0.3	-1.3
Average weekly spirits intake	0.3	0.4	0.8	0.3	0.6	-0.9
Sensitivity / hurt feelings	0.6	1.0	1.7	-1.1	0.3	1.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.2	0.3	0.6
Hearing difficulty/problems: Yes	2.8	4.3	4.8	2.1	2.2	-1.9
Relative age of first facial hair	0.4	0.8	2.2	-0.5	-1.5	0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	0.2	0.3	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.4	-0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.2	0.1	-0.9
Systolic blood pressure, automated reading	1.9	5.6	12.4	1.6	-1.4	-3.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	2.6	-1.5	-0.5	1.6
Angina	0.6	0.8	1.3	1.0	1.1	0.2
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.3	-0.9	0.4
Vitamin and mineral supplements	0.8	1.1	2.0	1.4	0.0	-1.2
Supplements: Zinc	1.9	2.0	3.7	1.0	1.9	-1.1
Medication: Co-codamol	1.0	1.2	2.3	-1.5	-1.2	-0.0
Medication: Metformin	0.3	0.4	0.8	-0.6	0.3	0.9
Diabetes (father)	0.5	0.6	1.6	-0.4	-0.0	-1.3
Diabetes (mother)	0.1	0.2	0.5	-0.0	0.3	-0.7
Severe depression (siblings)	0.3	0.3	0.7	-0.0	0.8	0.6
Pack years adult smoking proportion	0.9	1.4	2.2	-1.5	-0.1	1.5
Impedance of leg (right)	0.8	3.8	8.5	-0.7	-2.9	-1.6
Leg fat-free mass (left)	0.4	2.1	3.3	-0.7	1.8	1.6
Trunk fat percentage	0.1	0.3	0.4	0.3	0.6	-0.6
Hand grip strength (right)	0.2	0.5	0.8	-0.7	-0.9	0.4
Townsend deprivation index at recruitment	1.2	1.6	2.3	1.5	1.4	0.7
Current tobacco smoking	0.9	1.5	4.6	-0.2	0.1	2.1
Average weekly fortified wine intake	0.1	0.1	0.3	-0.2	0.6	-0.2
Maternal smoking around birth	2.5	3.7	6.4	-1.9	-2.5	1.0
Fed-up feelings	0.7	1.2	1.8	-1.3	-0.5	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.0	0.4	1.0	0.5
Relative age voice broke	0.2	0.3	0.7	0.8	-0.1	-0.4
Taking other prescription medications	1.8	2.7	4.2	2.0	0.3	-2.0
Age when periods started (menarche)	0.8	1.8	2.9	1.6	-0.1	-1.7
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.2	-0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	1.0	0.6	-0.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.1	1.2	-0.3	-2.3
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.7	0.3	-0.2
Serious illness, injury or assault to yourself	3.0	3.6	5.8	2.1	2.4	0.6
High blood pressure	1.6	4.4	9.4	1.3	-1.4	-3.1
Hayfever, allergic rhinitis or eczema	1.2	2.5	4.5	1.1	1.4	-2.1
Multivitamins +/- minerals	0.3	0.4	0.8	-0.9	0.5	0.5
Stomach or abdominal pain in last month	0.5	0.6	1.6	-0.4	1.3	-0.3
Supplements: Glucosamine	1.1	1.5	2.3	0.8	1.5	-1.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.3	0.8	0.0
Medication: Atenolol	1.1	1.4	2.9	0.4	-1.0	-1.7
Medication: Levothyroxine sodium	0.6	1.0	2.9	0.3	-1.7	0.3
Sitting height	0.1	0.9	1.9	-0.3	0.8	1.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.4	-0.0	-0.4
High blood pressure (mother)	0.7	1.0	1.6	1.3	-0.4	-1.1
Body mass index (BMI)	0.5	1.9	4.9	0.9	2.2	-0.3
Impedance of leg (left)	0.7	3.6	8.3	-1.3	-2.9	-1.0
Leg predicted mass (left)	0.4	2.2	3.1	-0.8	1.8	1.7
Trunk fat mass	0.1	0.2	0.6	-0.3	0.8	-0.1
Waist circumference	0.1	0.4	1.1	0.0	1.0	-0.4
Number of incorrect matches in round	1.6	2.7	5.2	-1.6	-2.3	-0.3
Past tobacco smoking	0.2	0.5	1.1	-1.0	0.3	0.4
Alcohol usually taken with meals	0.3	0.5	1.2	-0.3	1.1	0.6
Nervous feelings	3.3	6.2	9.7	-2.9	-3.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.5	0.7	0.3
Hearing difficulty/problems with background noise	0.8	1.2	2.4	0.8	0.8	-1.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.9	0.5	0.4
Had menopause	0.3	0.4	0.8	-0.3	-0.9	0.5
Had other major operations	0.2	0.3	0.5	0.5	0.7	-0.1
Forced vital capacity (FVC)	0.2	0.7	2.1	-0.2	0.3	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	1.8	1.0	0.5	-1.4
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.2	0.6	1.5	-1.8
Qualifications: None of the above	3.4	7.3	11.4	-3.2	-3.4	0.2
Financial difficulties in last 2 years	0.8	1.1	1.4	-1.2	-0.9	-1.0
Mouth/teeth dental problems	1.0	1.6	2.4	1.4	1.6	0.5
Heart attack	0.5	0.6	1.5	1.2	0.4	-0.3
Allergy	1.2	2.8	5.2	-1.3	-1.2	2.3
Pain all over the body in last month	0.1	0.1	0.3	0.1	-0.0	0.6
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.3	0.2	0.2	-1.8
Medication: Ramipril	1.9	2.5	5.7	-1.3	-2.4	0.3
Medication: Simvastatin	0.5	0.8	1.1	1.0	0.5	-1.1
Fluid intelligence score	3.9	8.0	11.7	3.4	3.3	-1.2
Illnesses of siblings	0.8	1.2	2.6	-1.6	-0.3	0.9
Neuroticism score	1.0	2.0	3.9	-2.0	-1.2	1.0
Weight	0.2	1.1	2.8	-0.5	1.7	0.3
Impedance of arm (right)	0.9	4.2	10.5	-0.5	-3.2	-1.4
Arm fat percentage (right)	0.2	0.8	1.0	0.8	0.9	-1.0
Trunk fat-free mass	0.4	2.1	2.7	-1.6	1.4	1.3
Hip circumference	0.7	3.0	8.1	1.0	2.8	0.0
Time employed in main current job	0.1	0.1	0.3	0.6	-0.2	0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.5	1.2	0.6	0.2
Father’s age at death	1.5	2.0	5.6	0.7	2.4	-0.2
Worrier / anxious feelings	1.0	1.9	2.6	-1.6	-1.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.0	-0.1	-0.6
Falls in the last year	1.9	2.6	3.6	1.9	1.9	-0.9
Hair/balding pattern: Pattern 3	0.5	0.8	1.9	-0.4	-0.6	-1.4
Number of live births	1.4	1.9	2.8	-1.5	-1.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.9	0.2	1.2	1.4
Pulse rate	1.0	1.7	3.1	1.4	0.4	-1.8
Happiness	1.4	1.7	4.0	1.0	2.0	-0.5
Noisy workplace	0.9	1.1	1.7	-1.3	0.2	1.2
Qualifications: A levels/AS levels or equivalent	2.3	5.1	7.3	2.7	2.6	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.8	-1.3	-0.8	-1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.2	-0.8	-0.4
Asthma	2.2	4.3	6.6	1.8	1.7	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.7	0.1	0.5
Medication: Cholesterol lowering	1.4	2.1	4.5	1.3	0.3	-2.1
Depression (self-reported)	0.3	0.3	0.6	0.2	0.8	-0.6
Medication: Lansoprazole	0.7	0.8	1.2	-0.6	-1.1	-1.0
Prospective memory result	1.9	2.3	4.1	-1.7	-2.0	-0.2
Lung cancer (father)	0.4	0.5	0.7	-0.8	-0.8	0.5
Illnesses of mother	1.3	1.6	2.5	0.9	1.6	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.5	0.1	0.9	1.2
Pulse wave Arterial Stiffness index	4.3	5.0	8.1	2.6	2.9	0.0
Impedance of arm (left)	0.6	3.0	6.2	0.4	-2.5	-1.6
Arm fat mass (right)	0.2	0.8	2.4	0.2	1.5	-0.2
Trunk predicted mass	0.4	2.2	2.9	-1.7	1.3	1.3
Standing height	0.4	3.5	8.1	-2.9	-0.7	1.4
Length of working week for main job	0.7	0.7	2.1	-0.2	-0.2	1.4
Exposure to tobacco smoke at home	0.4	0.5	1.0	0.5	-0.3	1.0
Breastfed as a baby	0.8	1.0	1.5	1.2	1.2	0.4
Tense / ‘highly strung’	1.2	2.1	3.1	-1.8	-1.8	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.5	-0.1
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	-1.4	-0.9	1.0
Birth weight of first child	0.6	1.2	3.0	-1.7	-0.2	0.7
Peak expiratory flow (PEF)	0.9	2.1	5.0	-1.0	0.5	2.2
Pulse wave reflection index	4.7	5.8	9.0	2.8	3.0	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.5	0.2	-0.7
Loud music exposure frequency	0.7	0.8	1.5	1.2	0.6	-0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	0.9	1.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-1.0	-0.2	-0.4
Blood clot in the leg (DVT)	0.8	1.0	2.5	0.7	-0.3	1.6
Medication: Paracetamol	2.9	4.8	5.3	-2.3	-2.3	2.0
Headache pain in last month	13.7	23.5	34.5	-5.9	-4.3	4.2
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	6.6	-1.1	0.4	2.6
Glaucoma (self-reported)	0.3	0.3	0.4	-0.6	0.4	0.6
Gout (self-reported)	0.9	1.2	2.8	0.2	-1.7	0.9
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	8.4	-0.6	-2.9	1.0
Medication: Amlodipine	1.6	2.2	5.2	1.0	0.6	-2.3
Medication: Ventolin 100micrograms inhaler	3.0	3.8	5.5	2.4	2.0	-1.5
Birth weight	1.3	2.7	6.2	-2.5	0.4	1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	1.0	-0.2	0.8
High blood pressure (siblings)	0.9	1.3	2.2	1.5	0.2	-1.3
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	-0.4	-0.2	1.3
Body fat percentage	0.1	0.6	1.0	0.5	0.7	-1.0
Leg fat percentage (right)	0.3	0.9	1.2	0.8	1.0	-1.1
Arm fat-free mass (right)	0.5	2.7	4.3	-1.2	2.1	1.6
Exposure to tobacco smoke outside home	2.9	3.8	8.6	-1.7	-0.1	2.9
Comparative body size at age 10	2.5	6.9	8.5	2.5	2.9	-2.4
Number of full brothers	0.0	0.1	0.1	0.2	0.3	0.2
Worry too long after embarrassment	0.7	1.2	2.6	-1.1	0.2	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	0.1	1.0	1.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.5	0.2	0.4	-1.2
Number of children fathered	0.9	1.0	1.5	-1.0	-0.8	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.7	-0.0	-0.2
Age at first live birth	1.6	2.9	6.4	2.5	1.4	-0.6
Pulse wave peak to peak time	5.0	5.9	9.1	-2.9	-3.0	0.1
Health satisfaction	1.3	1.7	2.0	1.3	1.4	-1.2
Shortness of breath walking on level ground	4.3	5.1	7.5	2.6	2.7	-1.1
Qualifications: College or University degree	2.3	7.4	9.5	2.9	3.1	-2.1
Eye problems/disorders: None of the above	0.5	0.6	1.0	-1.0	-0.8	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.2	-0.6	-0.9
Emphysema/chronic bronchitis	2.8	3.2	5.3	-2.3	-1.4	1.5
Medication for pain relief, constipation, heartburn	2.3	3.9	6.4	2.0	2.5	-1.1
Neck or shoulder pain in last month	1.0	1.4	2.9	-0.2	1.7	1.1
Medication: Blood pressure	1.2	2.1	4.5	0.6	-1.1	-2.1
Angina (self-reported)	0.9	1.2	1.9	1.3	1.4	0.2
Migraine (self-reported)	1.1	1.4	2.7	-1.6	-1.2	-0.1
Medication: Ibuprofen	0.5	0.6	1.6	0.5	1.2	0.3
Medication: Allopurinol	0.7	0.9	2.7	0.3	-1.7	-0.1
Medication: Omeprazole	0.2	0.2	0.3	0.6	0.3	-0.4
Medication: Seretide 50 evohaler	1.6	1.9	3.0	1.4	1.7	-0.7
Mean time to correctly identify matches	0.1	0.2	0.4	0.4	-0.4	-0.6
Heart disease (mother)	0.4	0.4	0.7	-0.2	-0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.9	-0.3	0.3
Whole body fat mass	0.1	0.4	1.2	0.0	1.1	-0.3
Leg fat mass (right)	0.1	0.5	1.5	0.1	1.2	0.0
Arm predicted mass (right)	0.6	2.8	3.5	-1.4	1.9	1.7
Pulse rate, automated reading	0.5	1.6	2.9	-1.3	-1.7	0.4
Alcohol intake frequency.	0.1	0.3	0.7	-0.2	0.3	0.9
Comparative height size at age 10	1.3	7.2	15.1	-3.9	-2.0	1.6
Number of full sisters	0.1	0.1	0.3	0.2	-0.6	0.2
Suffer from ‘nerves’	0.2	0.3	0.6	-0.3	-0.5	-0.8
Overall health rating	0.4	0.8	2.3	-0.2	-0.0	-1.5
Chest pain or discomfort	0.3	0.4	0.9	-0.9	-0.5	0.5
Had major operations	0.4	0.4	0.8	-0.9	-0.6	0.3
Age at last live birth	1.1	1.7	4.6	2.1	0.6	-0.0
Family relationship satisfaction	4.7	5.8	8.9	2.2	3.0	-1.9
Leg pain on walking	0.5	0.6	0.8	-0.9	-0.8	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	0.3	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	-0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.7	0.6	0.2
Medication: Aspirin	0.3	0.4	0.9	0.0	-0.9	-0.6
Supplements: Vitamin C	0.3	0.4	0.5	-0.6	-0.7	0.5
Knee pain experienced in last month	0.4	0.6	0.9	0.9	0.1	-1.0
Hypertension (Self-reported)	1.7	4.7	10.4	1.3	-1.5	-3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.3	-0.1	-0.2
Illnesses of father: Heart disease	1.2	1.7	4.5	2.1	0.8	0.0
Illnesses of siblings: Diabetes	0.1	0.2	0.3	0.5	-0.1	-0.5
Smoking status: Previous	0.4	0.6	1.0	0.4	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-1.0	-0.4	0.5
Whole body fat-free mass	0.4	2.4	2.9	-1.4	1.7	1.6
Leg fat-free mass (right)	0.5	2.7	4.1	-0.8	2.0	1.8
Arm fat percentage (left)	0.3	1.1	1.3	1.0	1.1	-1.0
Average weekly red wine intake	0.4	0.5	1.0	0.6	0.5	-1.0
Handedness (chirality/laterality): Left-handed	1.0	1.3	2.0	-0.8	-1.4	-1.0
Mood swings	0.1	0.2	0.3	-0.6	-0.6	-0.0
Loneliness, isolation	2.6	3.6	5.6	-1.9	-1.2	2.4
Long-standing illness, disability or infirmity	0.3	0.5	0.7	0.8	0.7	-0.6
Ever had bowel cancer screening	2.3	2.7	4.0	-2.0	-1.8	0.9
Diabetes diagnosed by doctor	0.3	0.4	1.2	-1.1	-0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	-0.5	-1.1	0.7
Friendships satisfaction	0.8	0.9	2.5	0.6	1.6	-0.1
Qualifications: nursing, teaching	0.8	1.2	2.0	1.3	1.4	-0.3
Commuting to job workplace: Walk	0.5	0.6	1.2	-0.0	-1.1	-0.7
Eye problems/disorders: Cataract	1.6	1.9	3.1	1.8	1.6	0.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.6	-1.3	-0.7	-0.3
Medication for cholesterol	0.4	0.6	1.1	-1.0	0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.7	-1.1	-0.7	1.3
Back pain experienced in last month	1.0	1.4	2.2	-1.5	-1.4	0.2
Mineral and other dietary supplements	0.5	0.7	1.7	-0.5	-1.3	-0.3
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Asthma (self-reported)	2.4	4.8	8.1	1.8	1.7	-2.9
Osteoporosis (self-reported)	0.3	0.4	0.7	0.4	0.5	-0.8
Osteoarthritis (self-reported)	3.2	4.1	7.4	1.9	1.1	-2.7
Medication: Aspirin	0.2	0.3	0.4	0.2	-0.6	-0.6
Medication: Gliclazide	2.0	2.2	3.2	1.8	1.2	-1.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.7	0.3	0.1
Smoking status: Current	1.4	2.2	6.4	-0.6	-0.1	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.6	0.5	1.3	1.2
Whole body water mass	0.4	2.4	3.1	-1.3	1.8	1.6
Leg predicted mass (right)	0.5	2.7	4.2	-0.8	2.0	1.8
Arm fat mass (left)	0.2	0.9	2.4	0.4	1.5	-0.4
Number of self-reported non-cancer illnesses	1.8	3.1	8.3	0.9	-0.4	-2.9
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.1	0.3	-0.7
Miserableness	2.4	4.2	6.8	-2.6	-1.6	1.7
Guilty feelings	1.1	1.6	3.7	-1.9	-1.0	0.5
Wears glasses or contact lenses	0.6	0.7	1.8	0.6	1.3	-0.1
Ever taken oral contraceptive pill	2.3	2.6	3.7	1.9	1.9	-0.7
Hearing aid user	3.8	4.3	6.6	2.5	2.6	-0.4
Mother’s age at death	1.1	1.4	3.9	-0.2	2.0	0.3
Financial situation satisfaction	1.0	1.3	1.9	1.4	0.8	-1.2
Tinnitus: Yes, now most or all of the time	3.0	3.5	5.6	2.2	2.4	0.1
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.3	0.1	0.9
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	0.5	0.0
Medication: Blood pressure	1.2	2.3	3.7	1.7	-0.4	-1.9
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.3	-0.6	-1.3	-2.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.8	0.8	0.3
High cholesterol (Self-reported)	1.5	2.7	5.0	1.6	0.8	-2.2
Medication: Bendroflumethiazide	3.2	4.9	8.7	3.0	0.6	-2.3
Medication: Paracetamol	1.9	2.9	3.7	-1.8	-1.9	1.4
Medication: Lisinopril	2.5	3.3	5.3	2.0	0.7	-2.3
Medication: Atorvastatin	1.0	1.3	2.1	-0.6	-1.4	-1.2
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.5	-0.9	0.1
Alcohol drinker status: Never	1.7	2.1	3.5	-1.5	-0.6	1.9
Ever smoked	1.8	3.2	6.0	2.4	1.7	-0.9
Basal metabolic rate	0.4	2.2	3.3	-1.2	1.8	1.4
Leg fat percentage (left)	0.2	0.7	1.2	0.5	1.1	-0.8
Arm fat-free mass (left)	0.5	2.4	3.0	-1.7	1.6	1.2
Number of operations (self-reported)	0.0	0.0	0.0	0.0	-0.2	0.1
Average weekly beer plus cider intake	3.0	4.4	6.6	-2.1	-1.5	2.6
Irritability	0.1	0.2	0.3	-0.4	0.4	-0.5
Risk taking	3.1	4.5	8.3	2.3	2.9	-0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-0.4	0.7	-1.3
Fractured/broken bones in last 5 years	3.8	4.9	9.5	2.2	3.1	0.5
Age started oral contraceptive pill	0.3	0.4	0.7	0.6	0.8	0.3
Diastolic blood pressure, automated reading	3.0	9.2	14.7	3.8	-0.8	-3.5
Ever depressed for a whole week	0.3	0.3	0.9	-0.3	-0.1	-0.9
Unable to work because of sickness or disability	0.7	0.9	1.9	1.4	0.9	0.3
Commuting to job workplace: Cycle	3.3	4.0	7.6	1.9	2.8	-0.9
Myopia	0.1	0.2	0.4	0.3	0.6	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.9	5.0	-1.0	1.6	2.2
Cholesterol lowering medication	0.0	0.0	0.0	-0.0	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	-0.1	-0.5
Pain experienced in last month	2.4	3.9	6.7	2.6	2.0	-0.9
Supplements: Calcium	0.5	0.6	1.3	-0.7	-0.1	1.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	1.4	0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.9	0.7	-0.3	1.7
Heart disease (siblings)	2.0	2.5	3.5	1.9	0.9	-1.8
Alcohol drinker status: Previous	1.4	1.6	4.2	-0.1	-0.7	-2.0
Pack years of smoking	1.0	1.5	2.5	-1.6	-0.2	1.4
Impedance of whole body	0.8	4.2	10.1	-0.6	-3.2	-1.4
Leg fat mass (left)	0.2	0.6	1.9	-0.0	1.4	0.2
Arm predicted mass (left)	0.5	2.6	2.9	-1.6	1.7	1.5