TWAS hub - PPP1CC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0208	0.0085	3.8e-06	0.016	0.017	0.018	0.018	0.015	2.8e-06	2.8e-06	1.1e-06	1.2e-06	9.6e-06
2	TCGA	Cervical Squamous Cell Carcinoma	0.0480	0.0310	7.3e-03	0.020	0.039	0.022	NA	0.016	3.6e-02	5.2e-03	2.7e-02	NA	5.1e-02
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0525	0.0286	4.9e-03	0.012	0.020	0.017	NA	0.007	1.4e-02	2.1e-03	4.7e-03	NA	5.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Headache pain in last month	13.7	23.5	34.5	-5.9	-4.3	4.2
Neuroticism (2016)	6.9	10.0	15.5	-3.9	-2.3	3.0
Verbal and Numeric Reasoning (VNR)	6.2	14.9	19.5	4.4	4.3	-2.5
Pulse wave peak to peak time	5.0	5.9	9.1	-2.9	-3.0	0.1
Schizophrenia (2018)	4.7	9.8	19.5	-3.0	-4.4	-1.0
Pulse wave reflection index	4.7	5.8	9.0	2.8	3.0	0.6
Family relationship satisfaction	4.7	5.8	8.9	2.2	3.0	-1.9
Schizophrenia (2014)	4.4	9.8	19.6	-2.5	-4.4	-1.9
Intelligence (Savage-Jansen 2018)	4.3	13.1	17.5	4.2	4.2	-2.1
Pulse wave Arterial Stiffness index	4.3	5.0	8.1	2.6	2.9	0.0
Shortness of breath walking on level ground	4.3	5.1	7.5	2.6	2.7	-1.1
Fluid intelligence score	3.9	8.0	11.7	3.4	3.3	-1.2
Hearing aid user	3.8	4.3	6.6	2.5	2.6	-0.4
Fractured/broken bones in last 5 years	3.8	4.9	9.5	2.2	3.1	0.5
Qualifications: None of the above	3.4	7.3	11.4	-3.2	-3.4	0.2
Nervous feelings	3.3	6.2	9.7	-2.9	-3.1	-0.6
Commuting to job workplace: Cycle	3.3	4.0	7.6	1.9	2.8	-0.9
Osteoarthritis (self-reported)	3.2	4.1	7.4	1.9	1.1	-2.7
Medication: Bendroflumethiazide	3.2	4.9	8.7	3.0	0.6	-2.3
Risk taking	3.1	4.5	8.3	2.3	2.9	-0.3
Serious illness, injury or assault to yourself	3.0	3.6	5.8	2.1	2.4	0.6
Medication: Ventolin 100micrograms inhaler	3.0	3.8	5.5	2.4	2.0	-1.5
Tinnitus: Yes, now most or all of the time	3.0	3.5	5.6	2.2	2.4	0.1
Average weekly beer plus cider intake	3.0	4.4	6.6	-2.1	-1.5	2.6
Diastolic blood pressure, automated reading	3.0	9.2	14.7	3.8	-0.8	-3.5
Blood Platelet Count	2.9	33.1	95.6	9.8	1.9	-0.4
Medication: Paracetamol	2.9	4.8	5.3	-2.3	-2.3	2.0
Exposure to tobacco smoke outside home	2.9	3.8	8.6	-1.7	-0.1	2.9
Lupus	2.8	4.3	7.5	-2.2	-2.7	0.5
Hearing difficulty/problems: Yes	2.8	4.3	4.8	2.1	2.2	-1.9
Emphysema/chronic bronchitis	2.8	3.2	5.3	-2.3	-1.4	1.5
Coronary Artery Disease (CAD)	2.6	3.2	8.1	-1.0	-2.9	-0.5
Crohns Disease (2012)	2.6	4.2	8.0	2.8	1.7	-1.2
Loneliness, isolation	2.6	3.6	5.6	-1.9	-1.2	2.4
Crohns Disease (2017)	2.5	5.5	8.1	2.8	2.3	-1.7
Maternal smoking around birth	2.5	3.7	6.4	-1.9	-2.5	1.0
Comparative body size at age 10	2.5	6.9	8.5	2.5	2.9	-2.4
Medication: Lisinopril	2.5	3.3	5.3	2.0	0.7	-2.3
Bipolar Disorder or Schizophrenia	2.4	5.9	9.4	-2.2	-3.1	-1.8
Asthma (self-reported)	2.4	4.8	8.1	1.8	1.7	-2.9
Miserableness	2.4	4.2	6.8	-2.6	-1.6	1.7
Pain experienced in last month	2.4	3.9	6.7	2.6	2.0	-0.9
Qualifications: A levels/AS levels or equivalent	2.3	5.1	7.3	2.7	2.6	-1.2
Qualifications: College or University degree	2.3	7.4	9.5	2.9	3.1	-2.1
Medication for pain relief, constipation, heartburn	2.3	3.9	6.4	2.0	2.5	-1.1
Ever had bowel cancer screening	2.3	2.7	4.0	-2.0	-1.8	0.9
Ever taken oral contraceptive pill	2.3	2.6	3.7	1.9	1.9	-0.7
Schizophrenia vs Biploar Disorder	2.2	2.9	7.0	-0.4	-2.7	-1.2
Asthma	2.2	4.3	6.6	1.8	1.7	-2.6
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.1	1.2	-0.3	-2.3
Worry (Nagel 2018)	2.0	4.3	6.4	-2.4	-2.5	0.8
Alzheimer’s Disease (in mother)	2.0	2.3	3.1	-1.8	-1.2	1.5
Age at First Birth	2.0	2.9	4.3	2.1	1.8	-1.1
Medication: Gliclazide	2.0	2.2	3.2	1.8	1.2	-1.4
Heart disease (siblings)	2.0	2.5	3.5	1.9	0.9	-1.8
Hypothyroidism (self reported)	1.9	4.3	11.4	-0.2	-3.4	1.2
Systolic blood pressure, automated reading	1.9	5.6	12.4	1.6	-1.4	-3.5
Supplements: Zinc	1.9	2.0	3.7	1.0	1.9	-1.1
Medication: Ramipril	1.9	2.5	5.7	-1.3	-2.4	0.3
Falls in the last year	1.9	2.6	3.6	1.9	1.9	-0.9
Prospective memory result	1.9	2.3	4.1	-1.7	-2.0	-0.2
Medication: Paracetamol	1.9	2.9	3.7	-1.8	-1.9	1.4
Taking other prescription medications	1.8	2.7	4.2	2.0	0.3	-2.0
Number of self-reported non-cancer illnesses	1.8	3.1	8.3	0.9	-0.4	-2.9
Ever smoked	1.8	3.2	6.0	2.4	1.7	-0.9
Blood Eosinophil Count	1.7	12.8	27.2	5.2	-3.4	0.0
Systolic Blood Pressure	1.7	8.7	11.8	1.8	-3.3	-3.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	8.4	-0.6	-2.9	1.0
Hypertension (Self-reported)	1.7	4.7	10.4	1.3	-1.5	-3.2
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.3	-0.6	-1.3	-2.1
Alcohol drinker status: Never	1.7	2.1	3.5	-1.5	-0.6	1.9
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	2.6	-1.5	-0.5	1.6
High blood pressure	1.6	4.4	9.4	1.3	-1.4	-3.1
Number of incorrect matches in round	1.6	2.7	5.2	-1.6	-2.3	-0.3
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.2	0.6	1.5	-1.8
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	6.6	-1.1	0.4	2.6
Medication: Amlodipine	1.6	2.2	5.2	1.0	0.6	-2.3
Age at first live birth	1.6	2.9	6.4	2.5	1.4	-0.6
Medication: Seretide 50 evohaler	1.6	1.9	3.0	1.4	1.7	-0.7
Eye problems/disorders: Cataract	1.6	1.9	3.1	1.8	1.6	0.0
Father’s age at death	1.5	2.0	5.6	0.7	2.4	-0.2
High cholesterol (Self-reported)	1.5	2.7	5.0	1.6	0.8	-2.2
HDL Cholesterol	1.4	2.4	3.2	1.8	1.1	-1.6
Number of live births	1.4	1.9	2.8	-1.5	-1.7	0.8
Happiness	1.4	1.7	4.0	1.0	2.0	-0.5
Medication: Cholesterol lowering	1.4	2.1	4.5	1.3	0.3	-2.1
Smoking status: Current	1.4	2.2	6.4	-0.6	-0.1	2.5
Alcohol drinker status: Previous	1.4	1.6	4.2	-0.1	-0.7	-2.0
Depression (Nagel 2018)	1.3	2.0	3.5	1.5	1.9	-0.6
Illnesses of mother	1.3	1.6	2.5	0.9	1.6	-1.2
Birth weight	1.3	2.7	6.2	-2.5	0.4	1.3
Health satisfaction	1.3	1.7	2.0	1.3	1.4	-1.2
Comparative height size at age 10	1.3	7.2	15.1	-3.9	-2.0	1.6
Cardiovascular Disease	1.2	4.1	8.2	1.6	-1.3	-2.9
Townsend deprivation index at recruitment	1.2	1.6	2.3	1.5	1.4	0.7
Hayfever, allergic rhinitis or eczema	1.2	2.5	4.5	1.1	1.4	-2.1
Allergy	1.2	2.8	5.2	-1.3	-1.2	2.3
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.8	-1.3	-0.8	-1.3
Tense / ‘highly strung’	1.2	2.1	3.1	-1.8	-1.8	-0.0
Medication: Blood pressure	1.2	2.1	4.5	0.6	-1.1	-2.1
Illnesses of father: Heart disease	1.2	1.7	4.5	2.1	0.8	0.0
Medication: Blood pressure	1.2	2.3	3.7	1.7	-0.4	-1.9
Irritable Bowel Disease (IBD)	1.1	2.7	4.2	2.0	0.8	-1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.9	0.7	1.4	-1.2
Supplements: Glucosamine	1.1	1.5	2.3	0.8	1.5	-1.2
Medication: Atenolol	1.1	1.4	2.9	0.4	-1.0	-1.7
Migraine (self-reported)	1.1	1.4	2.7	-1.6	-1.2	-0.1
Age at last live birth	1.1	1.7	4.6	2.1	0.6	-0.0
Guilty feelings	1.1	1.6	3.7	-1.9	-1.0	0.5
Mother’s age at death	1.1	1.4	3.9	-0.2	2.0	0.3
Lung FVC	1.0	5.1	6.1	2.2	2.1	2.5
Chronotype (morning person)	1.0	2.3	3.5	-0.9	-1.9	1.7
Medication: Co-codamol	1.0	1.2	2.3	-1.5	-1.2	-0.0
Mouth/teeth dental problems	1.0	1.6	2.4	1.4	1.6	0.5
Neuroticism score	1.0	2.0	3.9	-2.0	-1.2	1.0
Worrier / anxious feelings	1.0	1.9	2.6	-1.6	-1.4	1.1
Pulse rate	1.0	1.7	3.1	1.4	0.4	-1.8
Neck or shoulder pain in last month	1.0	1.4	2.9	-0.2	1.7	1.1
Handedness (chirality/laterality): Left-handed	1.0	1.3	2.0	-0.8	-1.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.7	-1.1	-0.7	1.3
Back pain experienced in last month	1.0	1.4	2.2	-1.5	-1.4	0.2
Financial situation satisfaction	1.0	1.3	1.9	1.4	0.8	-1.2
Medication: Atorvastatin	1.0	1.3	2.1	-0.6	-1.4	-1.2
Vascular/heart problems diagnosed by doctor	1.0	2.9	5.0	-1.0	1.6	2.2
Pack years of smoking	1.0	1.5	2.5	-1.6	-0.2	1.4
Respiratory disease	0.9	2.1	5.4	0.8	0.5	-2.3
Pack years adult smoking proportion	0.9	1.4	2.2	-1.5	-0.1	1.5
Current tobacco smoking	0.9	1.5	4.6	-0.2	0.1	2.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.3	0.2	0.2	-1.8
Impedance of arm (right)	0.9	4.2	10.5	-0.5	-3.2	-1.4
Noisy workplace	0.9	1.1	1.7	-1.3	0.2	1.2
Peak expiratory flow (PEF)	0.9	2.1	5.0	-1.0	0.5	2.2
Gout (self-reported)	0.9	1.2	2.8	0.2	-1.7	0.9
High blood pressure (siblings)	0.9	1.3	2.2	1.5	0.2	-1.3
Number of children fathered	0.9	1.0	1.5	-1.0	-0.8	1.2
Angina (self-reported)	0.9	1.2	1.9	1.3	1.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.9	0.7	-0.3	1.7
Heel T-Score	0.8	6.3	11.3	3.4	0.8	-2.6
Vitamin and mineral supplements	0.8	1.1	2.0	1.4	0.0	-1.2
Impedance of leg (right)	0.8	3.8	8.5	-0.7	-2.9	-1.6
Age when periods started (menarche)	0.8	1.8	2.9	1.6	-0.1	-1.7
Hearing difficulty/problems with background noise	0.8	1.2	2.4	0.8	0.8	-1.6
Financial difficulties in last 2 years	0.8	1.1	1.4	-1.2	-0.9	-1.0
Illnesses of siblings	0.8	1.2	2.6	-1.6	-0.3	0.9
Breastfed as a baby	0.8	1.0	1.5	1.2	1.2	0.4
Blood clot in the leg (DVT)	0.8	1.0	2.5	0.7	-0.3	1.6
Friendships satisfaction	0.8	0.9	2.5	0.6	1.6	-0.1
Qualifications: nursing, teaching	0.8	1.2	2.0	1.3	1.4	-0.3
Impedance of whole body	0.8	4.2	10.1	-0.6	-3.2	-1.4
Depressed Affect (Nagel 2018)	0.7	1.6	3.2	-1.8	-0.6	1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.1	-1.5	-0.7	0.5
Bipolar Disorder (2011)	0.7	0.7	1.6	-1.3	-0.7	0.2
LDL Cholesterol	0.7	1.1	3.0	-1.7	-0.2	0.6
Blood White Count	0.7	5.1	5.9	2.1	-2.2	2.4
Fed-up feelings	0.7	1.2	1.8	-1.3	-0.5	1.3
High blood pressure (mother)	0.7	1.0	1.6	1.3	-0.4	-1.1
Impedance of leg (left)	0.7	3.6	8.3	-1.3	-2.9	-1.0
Hip circumference	0.7	3.0	8.1	1.0	2.8	0.0
Medication: Lansoprazole	0.7	0.8	1.2	-0.6	-1.1	-1.0
Length of working week for main job	0.7	0.7	2.1	-0.2	-0.2	1.4
Loud music exposure frequency	0.7	0.8	1.5	1.2	0.6	-0.7
Worry too long after embarrassment	0.7	1.2	2.6	-1.1	0.2	1.6
Medication: Allopurinol	0.7	0.9	2.7	0.3	-1.7	-0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-0.4	0.7	-1.3
Unable to work because of sickness or disability	0.7	0.9	1.9	1.4	0.9	0.3
Bipolar Disorder (2018)	0.6	1.0	2.5	0.1	0.6	-1.6
Neuroticism (Nagel 2018)	0.6	1.5	3.4	-1.9	-0.7	0.8
Body Mass Index (BMI) (2010)	0.6	0.9	2.1	-0.7	1.4	0.3
BMI	0.6	3.6	9.1	1.3	3.0	-0.3
Neuroticism	0.6	1.4	3.4	-1.8	-0.8	0.4
Number of treatments/medications taken	0.6	1.1	1.7	1.3	0.3	-1.3
Sensitivity / hurt feelings	0.6	1.0	1.7	-1.1	0.3	1.3
Angina	0.6	0.8	1.3	1.0	1.1	0.2
Medication: Levothyroxine sodium	0.6	1.0	2.9	0.3	-1.7	0.3
Impedance of arm (left)	0.6	3.0	6.2	0.4	-2.5	-1.6
Birth weight of first child	0.6	1.2	3.0	-1.7	-0.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	0.1	1.0	1.2
Arm predicted mass (right)	0.6	2.8	3.5	-1.4	1.9	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	-0.5	-1.1	0.7
Wears glasses or contact lenses	0.6	0.7	1.8	0.6	1.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	1.4	0.6	-0.4
Major Depression (MDD)	0.5	0.6	1.0	-1.0	-0.7	0.6
Ovarian Cancer	0.5	0.7	1.1	-1.1	-0.7	0.7
Mean Putamen Volume	0.5	0.6	1.1	0.0	-0.9	-1.0
Rheumatoid Arthritis	0.5	0.7	0.8	0.9	0.8	0.7
Waist Hip Ratio (WHR)	0.5	2.3	5.1	-0.8	-2.2	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.5	0.1	-0.1	-1.6
Tanning	0.5	5.8	10.1	2.6	3.2	-0.6
Diabetes (father)	0.5	0.6	1.6	-0.4	-0.0	-1.3
Stomach or abdominal pain in last month	0.5	0.6	1.6	-0.4	1.3	-0.3
Body mass index (BMI)	0.5	1.9	4.9	0.9	2.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	1.8	1.0	0.5	-1.4
Heart attack	0.5	0.6	1.5	1.2	0.4	-0.3
Medication: Simvastatin	0.5	0.8	1.1	1.0	0.5	-1.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.9	-0.4	-0.6	-1.4
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	-1.4	-0.9	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	1.0	-0.2	0.8
Arm fat-free mass (right)	0.5	2.7	4.3	-1.2	2.1	1.6
Eye problems/disorders: None of the above	0.5	0.6	1.0	-1.0	-0.8	0.3
Medication: Ibuprofen	0.5	0.6	1.6	0.5	1.2	0.3
Pulse rate, automated reading	0.5	1.6	2.9	-1.3	-1.7	0.4
Leg pain on walking	0.5	0.6	0.8	-0.9	-0.8	-0.7
Leg fat-free mass (right)	0.5	2.7	4.1	-0.8	2.0	1.8
Commuting to job workplace: Walk	0.5	0.6	1.2	-0.0	-1.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.6	-1.3	-0.7	-0.3
Mineral and other dietary supplements	0.5	0.7	1.7	-0.5	-1.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.6	0.5	1.3	1.2
Leg predicted mass (right)	0.5	2.7	4.2	-0.8	2.0	1.8
Arm fat-free mass (left)	0.5	2.4	3.0	-1.7	1.6	1.2
Supplements: Calcium	0.5	0.6	1.3	-0.7	-0.1	1.1
Arm predicted mass (left)	0.5	2.6	2.9	-1.6	1.7	1.5
HbA1C	0.4	0.4	0.7	-0.9	-0.7	0.1
Blood Red Count	0.4	3.7	9.1	1.4	-3.0	-0.3
Allergy or Eczema	0.4	1.0	2.7	0.1	0.6	-1.6
Lung FEV1/FVC ratio	0.4	2.0	5.6	-0.1	2.4	0.5
Relative age of first facial hair	0.4	0.8	2.2	-0.5	-1.5	0.2
Leg fat-free mass (left)	0.4	2.1	3.3	-0.7	1.8	1.6
Leg predicted mass (left)	0.4	2.2	3.1	-0.8	1.8	1.7
Trunk fat-free mass	0.4	2.1	2.7	-1.6	1.4	1.3
Alcohol intake versus 10 years previously	0.4	0.6	1.5	1.2	0.6	0.2
Lung cancer (father)	0.4	0.5	0.7	-0.8	-0.8	0.5
Trunk predicted mass	0.4	2.2	2.9	-1.7	1.3	1.3
Standing height	0.4	3.5	8.1	-2.9	-0.7	1.4
Exposure to tobacco smoke at home	0.4	0.5	1.0	0.5	-0.3	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	0.9	1.1	0.1
Heart disease (mother)	0.4	0.4	0.7	-0.2	-0.8	-0.8
Overall health rating	0.4	0.8	2.3	-0.2	-0.0	-1.5
Had major operations	0.4	0.4	0.8	-0.9	-0.6	0.3
Knee pain experienced in last month	0.4	0.6	0.9	0.9	0.1	-1.0
Smoking status: Previous	0.4	0.6	1.0	0.4	-0.9	-1.0
Whole body fat-free mass	0.4	2.4	2.9	-1.4	1.7	1.6
Average weekly red wine intake	0.4	0.5	1.0	0.6	0.5	-1.0
Medication for cholesterol	0.4	0.6	1.1	-1.0	0.6	0.7
Whole body water mass	0.4	2.4	3.1	-1.3	1.8	1.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.8	0.8	0.3
Basal metabolic rate	0.4	2.2	3.3	-1.2	1.8	1.4
Ulcerative Colitis	0.3	0.4	0.5	0.6	-0.7	-0.7
Height	0.3	6.6	14.4	-3.8	-2.1	0.9
Hand grip strength (left)	0.3	0.8	1.1	-0.8	-0.7	1.0
Average weekly spirits intake	0.3	0.4	0.8	0.3	0.6	-0.9
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.2	0.1	-0.9
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.3	-0.9	0.4
Medication: Metformin	0.3	0.4	0.8	-0.6	0.3	0.9
Severe depression (siblings)	0.3	0.3	0.7	-0.0	0.8	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.0	0.4	1.0	0.5
Multivitamins +/- minerals	0.3	0.4	0.8	-0.9	0.5	0.5
Alcohol usually taken with meals	0.3	0.5	1.2	-0.3	1.1	0.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.9	0.5	0.4
Had menopause	0.3	0.4	0.8	-0.3	-0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.9	0.2	1.2	1.4
Depression (self-reported)	0.3	0.3	0.6	0.2	0.8	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.5	0.1	0.9	1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-1.0	-0.2	-0.4
Glaucoma (self-reported)	0.3	0.3	0.4	-0.6	0.4	0.6
Leg fat percentage (right)	0.3	0.9	1.2	0.8	1.0	-1.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.5	0.2	0.4	-1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.2	-0.6	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.9	-0.3	0.3
Chest pain or discomfort	0.3	0.4	0.9	-0.9	-0.5	0.5
Medication: Aspirin	0.3	0.4	0.9	0.0	-0.9	-0.6
Supplements: Vitamin C	0.3	0.4	0.5	-0.6	-0.7	0.5
Arm fat percentage (left)	0.3	1.1	1.3	1.0	1.1	-1.0
Long-standing illness, disability or infirmity	0.3	0.5	0.7	0.8	0.7	-0.6
Diabetes diagnosed by doctor	0.3	0.4	1.2	-1.1	-0.1	-0.3
Osteoporosis (self-reported)	0.3	0.4	0.7	0.4	0.5	-0.8
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.3	0.1	0.9
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.5	-0.9	0.1
Age started oral contraceptive pill	0.3	0.4	0.7	0.6	0.8	0.3
Ever depressed for a whole week	0.3	0.3	0.9	-0.3	-0.1	-0.9
Alzheimer’s Disease (in father)	0.2	0.3	0.4	0.3	0.6	-0.6
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.0	-0.9	-0.7
Reaction Time	0.2	0.4	0.8	0.5	-0.3	-0.9
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.7	0.8	0.0
Hair Pigment	0.2	4.7	9.7	-3.1	-1.8	1.1
Hand grip strength (right)	0.2	0.5	0.8	-0.7	-0.9	0.4
Relative age voice broke	0.2	0.3	0.7	0.8	-0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	1.0	0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.3	0.8	0.0
Past tobacco smoking	0.2	0.5	1.1	-1.0	0.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.5	0.7	0.3
Had other major operations	0.2	0.3	0.5	0.5	0.7	-0.1
Forced vital capacity (FVC)	0.2	0.7	2.1	-0.2	0.3	1.5
Weight	0.2	1.1	2.8	-0.5	1.7	0.3
Arm fat percentage (right)	0.2	0.8	1.0	0.8	0.9	-1.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.2	-0.8	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.7	0.1	0.5
Arm fat mass (right)	0.2	0.8	2.4	0.2	1.5	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.5	0.2	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	-0.4	-0.2	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.7	-0.0	-0.2
Medication: Omeprazole	0.2	0.2	0.3	0.6	0.3	-0.4
Suffer from ‘nerves’	0.2	0.3	0.6	-0.3	-0.5	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.7	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-1.0	-0.4	0.5
Medication: Aspirin	0.2	0.3	0.4	0.2	-0.6	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.7	0.3	0.1
Arm fat mass (left)	0.2	0.9	2.4	0.4	1.5	-0.4
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.1	0.3	-0.7
Leg fat percentage (left)	0.2	0.7	1.2	0.5	1.1	-0.8
Leg fat mass (left)	0.2	0.6	1.9	-0.0	1.4	0.2
Fasting Glucose	0.1	0.1	0.3	-0.2	0.1	-0.6
Triglycerides	0.1	0.2	0.4	0.2	0.2	-0.7
Smoking Status	0.1	0.3	0.4	0.6	-0.5	0.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.2	0.3	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.4	-0.2
Diabetes (mother)	0.1	0.2	0.5	-0.0	0.3	-0.7
Trunk fat percentage	0.1	0.3	0.4	0.3	0.6	-0.6
Average weekly fortified wine intake	0.1	0.1	0.3	-0.2	0.6	-0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.7	0.3	-0.2
Sitting height	0.1	0.9	1.9	-0.3	0.8	1.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.4	-0.0	-0.4
Trunk fat mass	0.1	0.2	0.6	-0.3	0.8	-0.1
Waist circumference	0.1	0.4	1.1	0.0	1.0	-0.4
Pain all over the body in last month	0.1	0.1	0.3	0.1	-0.0	0.6
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	0.4	-0.5
Time employed in main current job	0.1	0.1	0.3	0.6	-0.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.0	-0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.5	-0.1
Body fat percentage	0.1	0.6	1.0	0.5	0.7	-1.0
Mean time to correctly identify matches	0.1	0.2	0.4	0.4	-0.4	-0.6
Whole body fat mass	0.1	0.4	1.2	0.0	1.1	-0.3
Leg fat mass (right)	0.1	0.5	1.5	0.1	1.2	0.0
Alcohol intake frequency.	0.1	0.3	0.7	-0.2	0.3	0.9
Number of full sisters	0.1	0.1	0.3	0.2	-0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	-0.3	-0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.3	0.5	-0.1	-0.5
Mood swings	0.1	0.2	0.3	-0.6	-0.6	-0.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	0.5	0.0
Irritability	0.1	0.2	0.3	-0.4	0.4	-0.5
Myopia	0.1	0.2	0.4	0.3	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	-0.1	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	0.2	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.2	-0.1	-0.2
Number of full brothers	0.0	0.1	0.1	0.2	0.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.3	-0.1	-0.2
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Number of operations (self-reported)	0.0	0.0	0.0	0.0	-0.2	0.1
Cholesterol lowering medication	0.0	0.0	0.0	-0.0	-0.2	0.2
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.1

Hub : Genes

PPP1CC

Models

Trait associations