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chr1:109,098,737-110,733,794

Best TWAS P=3.94e-20 · Best GWAS P=3.17e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	6.532	-6.4	1.3e-10	-0.58	0.10	0.31	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	-1.263	6.3	2.3e-10	0.63	0.01	0.99	FALSE
3	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	9.042	9.2	3.9e-20	0.97	0.01	0.99	TRUE
4	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	9.042	9.0	1.5e-19	1.00	0.01	0.99	FALSE
5	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	0.091	5.2	2.3e-07	0.69	0.09	0.75	FALSE
6	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	9.042	8.9	4.2e-19	1.00	0.01	0.99	FALSE
7	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	8.030	7.3	3.7e-13	0.75	0.01	0.97	FALSE
8	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	9.173	9.0	1.5e-19	0.99	0.00	1.00	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	9.042	7.8	6.6e-15	0.82	0.00	1.00	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	9.042	8.9	4.7e-19	0.96	0.00	1.00	FALSE
11	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	9.042	7.8	5.0e-15	0.87	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	8.030	7.5	4.4e-14	0.80	0.02	0.89	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	9.155	6.5	6.8e-11	0.73	0.00	0.84	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	9.173	6.9	3.9e-12	0.58	0.00	0.79	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	8.030	8.0	9.8e-16	0.75	0.01	0.83	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSRC1	0.14	0.05	enet	6	0.08	7.5e-09	-1.417	5.9	4.7e-09	0.50	0.20	0.51	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	8.619	8.4	3.5e-17	0.92	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	8.511	8.6	8.0e-18	0.95	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	9.173	8.6	1.1e-17	0.94	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	9.155	7.1	1.5e-12	0.77	0.00	0.93	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	5.876	5.9	4.0e-09	0.67	0.01	0.36	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	9.042	6.2	6.4e-10	0.77	0.00	0.98	FALSE