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chr11:110,721,187-112,287,801

Best TWAS P=7.27e-10 · Best GWAS P=6.09e-10 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIK2	0.05	0.06	lasso	1	0.05	2.6e-06	-6.2	-6.2	7.3e-10	0.99	0.01	0.99	TRUE
3	GTEx	Esophagus Mucosa	SIK2	0.13	0.03	lasso	4	0.02	2.2e-02	-5.5	-5.7	1.6e-08	0.90	0.07	0.78	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIK2	0.04	0.01	blup	35	0.01	6.7e-03	-6.1	-5.6	2.1e-08	0.95	0.01	0.93	FALSE
4	The Cancer Genome Atlas	Breast Invasive Carcinoma	LAYN	0.02	0.03	blup	33	0.03	3.7e-06	-5.3	-5.3	1.1e-07	0.80	0.09	0.91	FALSE
2	GTEx	Brain Putamen basal ganglia	LAYN	0.24	0.12	lasso	7	0.13	6.2e-04	-5.2	5.3	1.4e-07	-0.81	0.08	0.60	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LAYN	0.19	0.24	bslmm	398	0.25	8.0e-30	-5.3	5.2	1.9e-07	-0.70	0.54	0.46	FALSE
6	The Cancer Genome Atlas	Lung Adenocarcinoma	HSPB2	0.03	0.01	blup	5	0.03	2.3e-04	-4.2	-5.2	2.4e-07	0.72	0.00	0.12	FALSE