Best TWAS P=7.27e-10 · Best GWAS P=6.09e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LAYN | 0.19 | 0.24 | bslmm | 398 | 0.25 | 8.0e-30 | -5.3 | 5.2 | 1.9e-07 | -0.70 | 0.54 | 0.46 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | LAYN | 0.24 | 0.12 | lasso | 7 | 0.13 | 6.2e-04 | -5.2 | 5.3 | 1.4e-07 | -0.81 | 0.08 | 0.60 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | -5.5 | -5.7 | 1.6e-08 | 0.90 | 0.07 | 0.78 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LAYN | 0.02 | 0.03 | blup | 33 | 0.03 | 3.7e-06 | -5.3 | -5.3 | 1.1e-07 | 0.80 | 0.09 | 0.91 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | -6.1 | -5.6 | 2.1e-08 | 0.95 | 0.01 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | HSPB2 | 0.03 | 0.01 | blup | 5 | 0.03 | 2.3e-04 | -4.2 | -5.2 | 2.4e-07 | 0.72 | 0.00 | 0.12 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIK2 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.6e-06 | -6.2 | -6.2 | 7.3e-10 | 0.99 | 0.01 | 0.99 | TRUE |