Best TWAS P=2.05e-24 · Best GWAS P=3.08e-25 conditioned to 0.0928
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Skin Sun Exposed Lower leg | MLLT10 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.0e-04 | 10.04 | -10.2 | 2.1e-24 | -0.94 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NEBL | 0.07 | 0.01 | blup | 662 | 0.03 | 9.7e-05 | -4.18 | -6.3 | 2.4e-10 | -0.03 | 0.76 | 0.01 | TRUE |
| 6 | GTEx | Spleen | MLLT10 | 0.16 | 0.02 | lasso | 7 | 0.02 | 1.0e-01 | 8.75 | -9.3 | 1.1e-20 | -0.92 | 0.02 | 0.68 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CASC10 | 0.08 | 0.02 | lasso | 5 | 0.01 | 6.1e-02 | 8.75 | 9.2 | 3.0e-20 | 0.90 | 0.10 | 0.78 | FALSE |
| 3 | GTEx | Artery Tibial | CASC10 | 0.05 | 0.06 | lasso | 4 | 0.02 | 1.3e-02 | 3.25 | 5.7 | 1.5e-08 | 0.52 | 0.31 | 0.37 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100499489 | 0.06 | 0.00 | bslmm | 297 | 0.02 | 1.2e-03 | 0.72 | -5.3 | 9.0e-08 | -0.49 | 0.02 | 0.74 | FALSE |
| 7 | YFS | Blood | MLLT10 | 0.02 | 0.01 | bslmm | 298 | 0.01 | 2.1e-03 | 3.96 | -5.2 | 2.5e-07 | -0.49 | 0.09 | 0.11 | FALSE |