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chr15:65,989,359-68,789,191

Best TWAS P=3.58e-29 · Best GWAS P=3.71e-41 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAP2K1	0.09	0.05	lasso	4	0.05	2.2e-06	5.2	5.3	9.5e-08	-0.08	0.05	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MAP2K5	0.11	0.07	bslmm	474	0.08	1.2e-09	-9.8	8.7	3.5e-18	-0.71	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	-9.7	9.8	1.7e-22	-0.77	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	-9.9	10.4	2.1e-25	-0.79	0.06	0.90	TRUE
5	GTEx	Adipose Visceral Omentum	CTD-3185P2.2	0.17	0.10	lasso	4	0.08	4.2e-05	5.2	-5.1	2.7e-07	0.06	0.06	0.86	FALSE
6	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	-9.8	9.6	5.4e-22	-0.78	0.31	0.53	FALSE
7	GTEx	Artery Coronary	MAP2K5	0.11	0.00	enet	28	0.03	4.5e-02	-4.5	5.4	6.1e-08	-0.57	0.12	0.19	FALSE
8	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	-9.8	9.8	1.5e-22	-0.76	1.00	0.00	FALSE
9	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-4.2	7.4	1.7e-13	-0.66	0.28	0.45	TRUE
10	GTEx	Brain Hippocampus	IQCH-AS1	0.20	0.08	enet	11	0.05	2.2e-02	6.6	-8.2	1.8e-16	0.47	0.17	0.10	FALSE
11	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	-11.7	10.8	4.9e-27	-0.87	0.03	0.97	FALSE
12	GTEx	Cells Transformed fibroblasts	SMAD3	0.12	0.01	lasso	9	0.06	3.6e-05	-2.8	-5.5	3.9e-08	0.19	0.25	0.04	FALSE
13	GTEx	Colon Transverse	IQCH-AS1	0.24	0.01	enet	31	0.08	1.5e-04	-10.4	-5.8	8.1e-09	0.04	0.40	0.04	FALSE
14	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	-9.8	9.6	7.3e-22	-0.77	1.00	0.00	FALSE
15	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	-9.8	10.7	7.2e-27	-0.76	0.47	0.52	TRUE
16	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	-9.7	10.0	1.2e-23	-0.80	0.76	0.17	FALSE
17	GTEx	Lung	MAP2K5	0.12	0.09	enet	11	0.07	3.6e-06	-9.8	8.4	6.2e-17	-0.71	0.97	0.01	TRUE
18	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	8.5	11.1	7.8e-29	-0.69	0.87	0.12	FALSE
19	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	-9.8	9.8	1.7e-22	-0.77	1.00	0.00	FALSE
20	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	-9.7	9.5	1.3e-21	-0.77	0.16	0.61	FALSE
21	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	6.7	9.3	1.8e-20	-0.65	0.95	0.05	FALSE
22	GTEx	Spleen	MAP2K5	0.25	0.19	lasso	3	0.18	2.1e-05	-9.8	8.3	1.5e-16	-0.76	0.07	0.87	FALSE
23	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	-9.7	9.8	1.6e-22	-0.77	0.98	0.02	FALSE
24	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	-9.8	8.8	1.2e-18	-0.74	0.61	0.28	FALSE
25	METSIM	Adipose	MAP2K5	0.07	0.05	enet	19	0.06	2.8e-09	-11.5	11.2	3.6e-29	-0.84	0.15	0.85	TRUE
26	NTR	Blood	MAP2K5	0.02	0.00	enet	13	0.01	5.7e-04	-9.3	8.4	4.4e-17	-0.72	0.24	0.71	FALSE
27	YFS	Blood	MAP2K1	0.07	0.05	lasso	3	0.05	2.0e-17	-5.7	6.1	1.0e-09	-0.04	0.02	0.98	TRUE
28	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	-9.7	9.6	9.1e-22	-0.77	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-4.4	6.2	6.3e-10	-0.47	0.99	0.01	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-4.8	5.3	1.5e-07	-0.47	0.41	0.14	FALSE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-4.8	7.2	6.4e-13	-0.57	0.12	0.77	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCH	0.06	0.04	blup	111	0.03	1.0e-04	-4.8	5.4	5.1e-08	-0.33	0.50	0.05	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K5	0.03	0.03	blup	142	0.02	1.6e-03	-9.8	10.6	2.1e-26	-0.90	0.05	0.93	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQCH	0.05	0.04	blup	111	0.04	7.7e-06	-4.7	6.0	2.6e-09	-0.40	0.64	0.25	FALSE
35	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IQCH	0.10	0.01	blup	111	0.03	1.4e-02	8.2	6.5	7.9e-11	-0.29	0.05	0.26	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCH	0.04	0.02	enet	8	0.01	1.6e-02	-8.1	7.4	1.7e-13	-0.41	0.12	0.12	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	LCTL	0.03	0.01	enet	7	0.02	5.2e-03	2.2	5.5	3.5e-08	-0.05	0.00	0.91	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	-9.8	10.0	1.1e-23	-0.79	0.12	0.85	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-9.9	8.2	3.2e-16	-0.70	0.01	0.98	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-8.1	7.5	9.0e-14	-0.58	0.06	0.94	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-4.7	5.5	3.1e-08	-0.38	0.37	0.23	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCH	0.19	0.07	blup	111	0.16	7.4e-17	-1.9	5.9	3.0e-09	-0.19	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Soft Tissue Sarcoma	LBXCOR1	0.07	0.03	blup	57	0.03	6.3e-03	-9.6	7.6	4.1e-14	-0.26	0.04	0.09	TRUE
44	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZWILCH	0.09	0.00	blup	68	0.02	1.3e-02	-5.2	5.3	1.1e-07	-0.10	0.02	0.15	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-4.7	5.3	1.3e-07	-0.37	0.10	0.07	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	-4.6	6.5	5.9e-11	-0.48	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	LBXCOR1	0.06	0.01	lasso	3	0.03	7.0e-04	-8.6	8.1	4.6e-16	-0.65	0.10	0.48	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	-9.8	10.1	4.3e-24	-0.82	0.63	0.33	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	SNAPC5	0.05	0.02	lasso	2	0.03	5.1e-04	3.4	-5.3	1.1e-07	0.04	0.01	0.59	FALSE