Best TWAS P=2.42e-17 · Best GWAS P=3.03e-20 conditioned to 4.48e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | C17orf103 | 0.16 | 0.06 | lasso | 5 | 0.06 | 2.1e-04 | -5.2 | 5.7 | 1.5e-08 | 0.35 | 0.20 | 0.40 | FALSE |
| 2 | GTEx | Lung | C17orf103 | 0.08 | 0.01 | enet | 11 | 0.04 | 6.6e-04 | 6.3 | 7.3 | 2.7e-13 | 0.53 | 0.18 | 0.40 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | C17orf103 | 0.11 | 0.02 | enet | 15 | 0.07 | 1.0e-06 | 3.5 | 6.5 | 1.1e-10 | 0.32 | 0.28 | 0.32 | FALSE |
| 4 | GTEx | Testis | C17orf103 | 0.15 | 0.21 | enet | 4 | 0.19 | 7.1e-09 | -5.2 | 5.9 | 3.8e-09 | 0.35 | 0.96 | 0.02 | FALSE |
| 5 | GTEx | Thyroid | DHRS7B | 0.17 | 0.02 | enet | 22 | 0.11 | 1.2e-08 | -4.3 | -5.5 | 3.0e-08 | -0.28 | 0.71 | 0.17 | FALSE |
| 6 | GTEx | Thyroid | KCNJ12 | 0.36 | 0.23 | lasso | 5 | 0.25 | 2.9e-19 | -6.7 | -8.5 | 2.4e-17 | -0.80 | 0.66 | 0.34 | TRUE |
| 7 | METSIM | Adipose | MAP2K3 | 0.08 | 0.02 | blup | 211 | 0.03 | 6.0e-05 | -5.0 | 5.6 | 2.0e-08 | 0.53 | 0.08 | 0.87 | FALSE |
| 8 | NTR | Blood | C17orf103 | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.6e-07 | -5.1 | 5.5 | 3.7e-08 | 0.34 | 0.98 | 0.01 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf103 | 0.08 | 0.01 | blup | 44 | 0.01 | 3.2e-02 | -5.2 | 5.3 | 1.0e-07 | 0.42 | 0.03 | 0.46 | FALSE |