Best TWAS P=2.94e-09 · Best GWAS P=2.26e-10 conditioned to 0.00286
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | ASB16-AS1 | 0.14 | 0.12 | lasso | 5 | 0.10 | 9.8e-06 | 5.4 | -5.5 | 3.8e-08 | -0.88 | 0.16 | 0.82 | FALSE |
| 2 | GTEx | Brain Cerebellum | DHX8 | 0.13 | -0.01 | lasso | 7 | -0.01 | 7.4e-01 | -3.2 | 5.5 | 4.2e-08 | -0.02 | 0.04 | 0.17 | FALSE |
| 3 | GTEx | Brain Cerebellum | RND2 | 0.13 | 0.02 | enet | 15 | 0.12 | 1.7e-04 | -3.2 | -5.2 | 1.5e-07 | 0.04 | 0.15 | 0.14 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | ASB16-AS1 | 0.08 | 0.04 | lasso | 2 | 0.06 | 7.9e-03 | 5.4 | -5.3 | 1.2e-07 | -0.87 | 0.06 | 0.42 | FALSE |
| 5 | GTEx | Esophagus Mucosa | TUBG2 | 0.09 | 0.09 | lasso | 4 | 0.11 | 5.5e-08 | -4.2 | -5.1 | 2.7e-07 | -0.08 | 0.03 | 0.95 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RP11-400F19.8 | 0.17 | 0.05 | lasso | 4 | 0.02 | 3.9e-02 | 4.1 | -5.3 | 1.5e-07 | -0.04 | 0.04 | 0.29 | TRUE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C17orf65 | 0.03 | 0.00 | blup | 37 | 0.01 | 2.3e-02 | 4.7 | -5.7 | 1.2e-08 | -0.89 | 0.04 | 0.67 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | C17orf65 | 0.05 | 0.06 | blup | 38 | 0.05 | 4.2e-04 | 3.9 | -5.1 | 2.9e-07 | -0.86 | 0.16 | 0.63 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ASB16 | 0.02 | 0.02 | blup | 39 | 0.02 | 3.8e-03 | 4.7 | -5.7 | 1.2e-08 | -0.86 | 0.02 | 0.38 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C17orf65 | 0.03 | 0.01 | lasso | 10 | 0.02 | 3.6e-03 | 5.9 | -5.8 | 7.3e-09 | -0.81 | 0.03 | 0.84 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARL4D | 0.05 | 0.03 | blup | 21 | 0.04 | 2.3e-05 | 4.5 | 5.3 | 9.2e-08 | -0.06 | 0.01 | 0.90 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ASB16 | 0.02 | 0.03 | blup | 40 | 0.03 | 1.3e-04 | 4.3 | -5.5 | 4.7e-08 | -0.89 | 0.20 | 0.77 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ARL4D | 0.10 | 0.03 | blup | 21 | 0.05 | 5.3e-04 | 4.6 | 5.6 | 2.5e-08 | -0.09 | 0.00 | 0.53 | TRUE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSD17B1 | 0.30 | 0.05 | enet | 14 | 0.06 | 2.8e-07 | -4.0 | -5.2 | 1.9e-07 | -0.09 | 0.20 | 0.66 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | RND2 | 0.08 | 0.00 | enet | 16 | 0.02 | 3.5e-03 | -4.4 | 5.6 | 2.6e-08 | 0.01 | 0.00 | 0.06 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C17orf65 | 0.07 | 0.02 | blup | 38 | 0.04 | 1.1e-02 | 5.4 | -5.9 | 2.9e-09 | -0.89 | 0.02 | 0.29 | TRUE |