[Hub]/) : Traits : BMI : ← →

chr17:44,831,932-48,199,585

Best TWAS P=9.71e-20 · Best GWAS P=5.27e-23 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ATP5G1	0.07	0.05	lasso	3	0.06	4.7e-08	-7.72	8.2	1.8e-16	-0.62	0.95	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CDK5RAP3	0.15	0.12	bslmm	392	0.14	3.6e-16	7.38	-7.5	9.5e-14	0.09	0.99	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	-7.51	9.1	9.7e-20	-0.84	0.03	0.97	TRUE
4	GTEx	Adipose Subcutaneous	CDK5RAP3	0.13	0.11	enet	11	0.14	1.4e-11	-1.94	-5.1	2.8e-07	0.12	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	MRPL45P2	0.24	0.00	enet	24	0.01	1.2e-01	6.44	-5.7	1.3e-08	0.08	0.04	0.33	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-6N17.9	0.13	0.04	enet	16	0.05	8.4e-04	-3.53	-6.0	2.1e-09	0.11	0.26	0.30	FALSE
7	GTEx	Artery Aorta	CDK5RAP3	0.26	0.22	lasso	11	0.25	5.8e-14	-4.86	-5.7	9.4e-09	0.12	1.00	0.00	FALSE
8	GTEx	Artery Aorta	SNF8	0.12	0.12	lasso	6	0.10	2.3e-06	-7.44	7.7	1.3e-14	-0.63	0.62	0.29	FALSE
9	GTEx	Artery Aorta	AC091133.1	0.10	0.07	lasso	5	0.07	1.2e-04	-7.44	8.2	3.6e-16	-0.65	0.36	0.36	FALSE
10	GTEx	Artery Aorta	RP11-6N17.9	0.23	0.12	enet	19	0.19	9.5e-11	-4.86	-5.8	7.8e-09	0.09	0.99	0.00	FALSE
11	GTEx	Artery Aorta	RP11-6N17.10	0.20	0.07	enet	24	0.14	3.5e-08	-4.86	-6.8	8.8e-12	0.11	0.50	0.11	FALSE
12	GTEx	Artery Coronary	PNPO	0.13	0.00	lasso	4	-0.01	5.9e-01	3.96	5.1	2.7e-07	-0.10	0.13	0.06	FALSE
13	GTEx	Artery Tibial	CDK5RAP3	0.24	0.23	lasso	5	0.22	3.2e-17	-4.86	-5.3	9.5e-08	0.11	1.00	0.00	FALSE
14	GTEx	Artery Tibial	RP11-6N17.9	0.16	0.14	lasso	4	0.12	6.2e-10	-4.86	-5.2	1.6e-07	0.12	1.00	0.00	FALSE
15	GTEx	Brain Caudate basal ganglia	RP11-6N17.9	0.45	-0.01	enet	28	0.16	3.3e-05	-0.57	-7.1	1.0e-12	0.09	0.06	0.13	FALSE
16	GTEx	Brain Cerebellar Hemisphere	CDK5RAP3	0.22	0.10	lasso	6	0.09	2.6e-03	6.44	-7.4	1.9e-13	0.09	0.08	0.39	FALSE
17	GTEx	Brain Cerebellar Hemisphere	RP11-6N17.10	0.21	0.16	lasso	5	0.13	3.8e-04	6.44	-7.0	1.7e-12	0.09	0.09	0.43	FALSE
18	GTEx	Brain Cerebellum	ATP5G1	0.22	0.26	lasso	3	0.24	8.2e-08	-7.16	7.2	5.4e-13	-0.59	0.76	0.16	FALSE
19	GTEx	Brain Cerebellum	RP11-6N17.9	0.31	0.22	lasso	6	0.19	2.3e-06	-4.86	-6.1	1.1e-09	0.12	0.26	0.08	FALSE
20	GTEx	Brain Cortex	ATP5G1	0.16	0.15	lasso	2	0.14	1.3e-04	-7.49	7.5	9.0e-14	-0.60	0.17	0.16	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	KPNB1	0.24	0.00	lasso	9	0.01	2.1e-01	6.99	-6.4	1.2e-10	0.04	0.02	0.79	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	CDK5RAP3	0.21	0.04	lasso	4	0.02	7.2e-02	7.75	-7.4	1.2e-13	0.08	0.08	0.35	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	RP11-6N17.9	0.47	0.05	lasso	17	0.11	8.3e-04	7.41	-7.3	2.4e-13	0.08	0.11	0.38	FALSE
24	GTEx	Cells Transformed fibroblasts	CDK5RAP3	0.19	0.09	lasso	6	0.16	4.8e-12	-4.86	-5.2	2.3e-07	0.10	1.00	0.00	FALSE
25	GTEx	Cells Transformed fibroblasts	SNF8	0.12	0.10	lasso	3	0.12	5.1e-09	-7.40	7.7	1.6e-14	-0.66	0.98	0.02	FALSE
26	GTEx	Cells Transformed fibroblasts	AC091133.1	0.14	0.07	enet	22	0.09	1.9e-07	-7.49	6.7	3.0e-11	-0.60	0.88	0.08	FALSE
27	GTEx	Cells Transformed fibroblasts	RP11-463M16.4	0.10	0.00	enet	21	0.01	2.8e-02	-7.39	5.9	3.3e-09	-0.42	0.27	0.08	TRUE
28	GTEx	Cells Transformed fibroblasts	RP11-6N17.9	0.14	0.04	enet	17	0.08	2.3e-06	-4.86	-5.4	5.6e-08	0.11	0.96	0.02	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	CDK5RAP3	0.21	0.09	lasso	6	0.07	1.2e-03	-4.86	-6.6	5.2e-11	0.10	0.09	0.51	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	RP11-6N17.9	0.18	0.14	lasso	3	0.09	4.9e-04	-4.86	-6.7	1.9e-11	0.12	0.03	0.73	FALSE
31	GTEx	Esophagus Mucosa	NFE2L1	0.07	0.02	lasso	4	0.01	8.6e-02	-5.63	-5.6	1.9e-08	0.09	0.32	0.03	FALSE
32	GTEx	Esophagus Muscularis	COPZ2	0.14	0.04	lasso	5	0.06	1.3e-04	2.75	6.0	2.5e-09	-0.05	0.18	0.04	TRUE
33	GTEx	Esophagus Muscularis	ATP5G1	0.09	0.06	lasso	5	0.05	4.5e-04	-7.49	7.5	6.2e-14	-0.60	0.10	0.69	FALSE
34	GTEx	Esophagus Muscularis	SNF8	0.08	0.03	lasso	3	0.01	5.7e-02	-8.05	7.8	7.2e-15	-0.71	0.02	0.83	FALSE
35	GTEx	Esophagus Muscularis	RP11-6N17.9	0.10	0.10	lasso	5	0.08	1.1e-05	-4.86	-5.5	4.2e-08	0.11	0.84	0.02	FALSE
36	GTEx	Heart Atrial Appendage	PNPO	0.16	0.07	enet	36	0.08	1.7e-04	3.96	-5.3	8.8e-08	0.00	0.71	0.02	FALSE
37	GTEx	Heart Atrial Appendage	CDK5RAP3	0.13	0.00	enet	18	0.04	5.1e-03	2.90	-8.2	3.2e-16	0.10	0.09	0.05	TRUE
38	GTEx	Heart Atrial Appendage	ATP5G1	0.22	0.10	enet	6	0.13	1.3e-06	-7.40	7.3	1.9e-13	-0.62	0.93	0.03	FALSE
39	GTEx	Heart Left Ventricle	ATP5G1	0.24	0.22	lasso	4	0.22	9.3e-12	-7.44	8.4	2.8e-17	-0.64	1.00	0.00	FALSE
40	GTEx	Liver	SCRN2	0.32	0.05	enet	14	0.11	5.5e-04	-3.31	5.2	1.7e-07	-0.02	0.10	0.56	FALSE
41	GTEx	Muscle Skeletal	COPZ2	0.12	0.03	enet	20	0.05	1.9e-05	2.75	5.1	2.7e-07	0.01	0.85	0.01	FALSE
42	GTEx	Muscle Skeletal	ATP5G1	0.13	0.08	enet	18	0.07	5.1e-07	-7.49	6.2	6.7e-10	-0.67	0.97	0.03	TRUE
43	GTEx	Muscle Skeletal	UBE2Z	0.06	0.02	lasso	8	0.03	9.8e-04	-7.44	8.0	1.9e-15	-0.66	0.59	0.24	FALSE
44	GTEx	Muscle Skeletal	AC003665.1	0.05	0.03	enet	8	0.03	1.4e-03	5.72	7.3	2.3e-13	-0.11	0.12	0.72	FALSE
45	GTEx	Nerve Tibial	CDK5RAP3	0.41	0.35	enet	23	0.36	6.1e-27	-4.86	-5.9	4.0e-09	0.12	1.00	0.00	FALSE
46	GTEx	Nerve Tibial	UBE2Z	0.12	0.04	enet	16	0.05	1.5e-04	-7.44	7.1	9.0e-13	-0.60	0.89	0.01	FALSE
47	GTEx	Nerve Tibial	RP11-6N17.9	0.29	0.27	lasso	4	0.27	2.1e-19	-4.86	-5.7	1.1e-08	0.12	1.00	0.00	FALSE
48	GTEx	Nerve Tibial	RP11-6N17.10	0.28	0.19	lasso	8	0.19	1.6e-13	-4.86	-6.1	9.8e-10	0.12	1.00	0.00	FALSE
49	GTEx	Ovary	ATP5G1	0.15	0.08	enet	13	0.09	2.8e-03	-7.08	7.5	4.6e-14	-0.66	0.09	0.61	FALSE
50	GTEx	Pancreas	CDK5RAP3	0.11	-0.01	lasso	4	0.02	5.1e-02	6.44	-6.9	5.7e-12	0.04	0.09	0.18	FALSE
51	GTEx	Pancreas	AC004797.1	0.21	0.00	enet	32	0.06	1.0e-03	0.54	-5.5	3.9e-08	0.42	0.05	0.11	TRUE
52	GTEx	Pancreas	RP11-6N17.9	0.15	0.04	lasso	5	0.04	9.3e-03	-2.41	-7.1	1.2e-12	0.07	0.13	0.16	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	UBE2Z	0.11	0.07	lasso	6	0.04	1.8e-03	-8.05	8.0	9.5e-16	-0.68	0.09	0.18	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	HOXB-AS1	0.09	0.00	enet	34	0.00	3.4e-01	-2.39	6.2	6.6e-10	-0.23	0.19	0.05	TRUE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP11-6N17.9	0.10	0.01	lasso	6	0.05	7.9e-04	7.01	-5.6	2.6e-08	0.07	0.08	0.11	FALSE
56	GTEx	Skin Sun Exposed Lower leg	CDK5RAP3	0.10	0.02	lasso	5	0.04	2.8e-04	6.99	-7.2	8.0e-13	0.11	0.22	0.29	FALSE
57	GTEx	Skin Sun Exposed Lower leg	UBE2Z	0.14	0.11	lasso	9	0.14	6.3e-12	-7.16	8.1	6.4e-16	-0.64	1.00	0.00	FALSE
58	GTEx	Stomach	RP11-6N17.9	0.13	0.02	lasso	6	0.04	8.0e-03	6.75	-7.8	7.3e-15	0.06	0.12	0.69	FALSE
59	GTEx	Testis	CDK5RAP3	0.22	0.29	lasso	8	0.25	2.6e-11	6.99	-7.0	3.3e-12	0.06	0.81	0.19	FALSE
60	GTEx	Testis	SNF8	0.23	0.11	lasso	5	0.08	1.6e-04	-7.44	7.2	5.0e-13	-0.62	0.69	0.07	FALSE
61	GTEx	Testis	RP11-6N17.9	0.13	0.20	lasso	1	0.19	6.8e-09	6.99	-7.0	2.7e-12	0.06	0.56	0.41	FALSE
62	GTEx	Testis	RP11-6N17.10	0.13	0.12	lasso	2	0.09	6.3e-05	6.99	-7.2	7.1e-13	0.06	0.51	0.33	FALSE
63	GTEx	Testis	RP11-6N17.4	0.14	0.02	lasso	10	0.02	4.8e-02	7.80	7.7	2.0e-14	-0.07	0.18	0.65	FALSE
64	GTEx	Thyroid	CDK5RAP3	0.21	0.14	lasso	5	0.18	1.6e-13	-4.86	-7.3	2.7e-13	0.13	1.00	0.00	FALSE
65	GTEx	Thyroid	ATP5G1	0.09	0.04	enet	19	0.10	6.9e-08	-7.49	7.1	1.6e-12	-0.66	0.07	0.92	FALSE
66	GTEx	Thyroid	SNF8	0.11	0.08	lasso	3	0.07	2.5e-06	-7.49	7.8	8.2e-15	-0.61	0.79	0.19	FALSE
67	GTEx	Thyroid	RP11-6N17.9	0.22	0.14	lasso	5	0.14	5.2e-11	-4.86	-6.8	7.2e-12	0.12	1.00	0.00	FALSE
68	GTEx	Thyroid	RP11-6N17.10	0.19	0.12	lasso	5	0.13	3.0e-10	-4.86	-7.6	2.7e-14	0.13	1.00	0.00	FALSE
69	GTEx	Uterus	CDK5RAP3	0.41	0.28	lasso	5	0.26	4.5e-06	-4.86	-5.7	1.2e-08	0.11	0.11	0.05	FALSE
70	GTEx	Uterus	RP11-6N17.10	0.43	0.26	lasso	6	0.24	1.3e-05	-4.86	-5.8	6.9e-09	0.12	0.09	0.07	FALSE
71	GTEx	Vagina	HOXB2	0.16	0.03	lasso	10	0.09	5.3e-03	-3.49	5.4	7.9e-08	-0.10	0.11	0.10	FALSE
72	METSIM	Adipose	CDK5RAP3	0.11	0.06	bslmm	385	0.11	5.4e-16	7.38	-6.0	2.1e-09	0.10	0.11	0.89	FALSE
73	METSIM	Adipose	HOXB9	0.06	0.03	enet	17	0.05	9.9e-08	-4.46	5.4	5.8e-08	-0.08	1.00	0.00	FALSE
74	YFS	Blood	HOXB4	0.03	0.02	blup	396	0.01	7.3e-05	-4.46	5.7	1.1e-08	0.05	0.90	0.00	TRUE
75	YFS	Blood	UBE2Z	0.06	0.03	enet	19	0.06	1.5e-18	1.32	5.4	5.6e-08	-0.35	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK5RAP3	0.05	0.03	lasso	2	0.02	1.8e-05	6.75	-6.8	1.2e-11	0.07	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNF8	0.01	0.01	blup	47	0.01	9.1e-03	-4.95	7.0	1.8e-12	-0.60	0.06	0.18	FALSE
78	The Cancer Genome Atlas	Glioblastoma Multiforme	SNF8	0.09	0.06	blup	47	0.07	4.3e-03	-5.73	6.3	2.5e-10	-0.54	0.09	0.09	FALSE
79	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBX1	0.03	0.01	lasso	3	0.01	8.7e-03	7.75	-7.5	9.2e-14	0.09	0.01	0.83	FALSE
80	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNF8	0.03	0.01	blup	47	0.03	1.0e-02	-4.82	6.0	1.9e-09	-0.50	0.07	0.08	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATP5G1	0.08	0.02	enet	7	0.02	3.1e-03	-7.16	6.7	2.1e-11	-0.59	0.02	0.77	TRUE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	CALCOCO2	0.03	0.00	blup	50	0.01	1.9e-02	5.87	7.8	6.9e-15	-0.55	0.02	0.85	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNF8	0.11	0.12	lasso	4	0.12	1.4e-13	-7.56	7.7	1.5e-14	-0.65	0.97	0.03	TRUE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL6	0.03	0.00	blup	59	0.02	2.7e-03	-5.65	-6.7	2.0e-11	0.54	0.02	0.83	FALSE
85	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX11	0.06	0.06	lasso	3	0.05	2.8e-06	-5.63	5.8	7.7e-09	-0.09	0.91	0.00	FALSE
86	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TTLL6	0.14	0.04	enet	6	0.06	1.4e-03	-7.21	-5.8	8.6e-09	0.23	0.02	0.59	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBX1	0.03	0.04	lasso	4	0.04	3.7e-05	7.79	-7.7	1.3e-14	0.07	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK5RAP3	0.06	0.00	blup	62	0.03	1.0e-03	-5.93	-8.1	4.0e-16	0.07	0.01	0.83	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNF8	0.05	0.06	blup	47	0.06	1.0e-06	-8.05	7.6	3.2e-14	-0.64	0.74	0.25	FALSE
90	The Cancer Genome Atlas	Soft Tissue Sarcoma	CDK5RAP3	0.13	0.02	blup	61	0.04	1.2e-03	-5.50	-5.6	1.8e-08	0.13	0.10	0.13	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	ATP5G1	0.19	0.03	lasso	3	0.08	4.4e-08	1.54	5.9	4.0e-09	-0.52	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	CALCOCO2	0.07	0.05	enet	9	0.06	1.3e-06	-7.45	7.6	2.4e-14	-0.47	0.08	0.87	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	SNF8	0.16	0.18	lasso	7	0.18	5.9e-17	-7.44	7.5	7.7e-14	-0.64	0.97	0.03	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	UBE2Z	0.13	0.09	lasso	4	0.12	2.7e-11	-7.39	7.8	7.8e-15	-0.64	0.85	0.15	FALSE