Hub : Genes

RPTOR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.2320 0.0570 7.3e-05 0.009 NA 0.003 NA 0.032 8.7e-02 NA 1.9e-01 NA 4.5e-03
2 GTEx Muscle Skeletal 0.1430 0.0384 1.3e-06 0.051 NA 0.086 NA 0.079 8.6e-06 NA 8.4e-09 NA 3.4e-08
3 GTEx Skin Not Sun Exposed Suprapubic 0.2510 0.0540 7.0e-08 0.121 NA 0.242 NA 0.242 3.7e-07 NA 1.7e-13 NA 1.6e-13
4 GTEx Skin Sun Exposed Lower leg 0.2930 0.0430 1.7e-15 0.267 NA 0.297 NA 0.304 3.6e-22 NA 6.8e-25 NA 1.6e-25
5 NTR Blood 0.0352 0.0120 6.7e-04 0.003 0.010 0.002 0.009 0.005 3.9e-02 3e-04 5.8e-02 0.00047 7.9e-03
6 TCGA Thyroid Carcinoma 0.0940 0.0380 1.1e-03 -0.001 0.036 0.028 NA 0.002 4.0e-01 2e-04 8.7e-04 NA 2.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.8 1.3 3.3 -0.4 0.1 1.3 0.8 1.8 1.4
Bipolar Disorder or Schizophrenia 1.1 2.7 5.8 0.3 -0.2 1.9 0.9 2.4 2.4
Depressed Affect (Nagel 2018) 0.6 1.2 3.0 1.0 0.6 -1.1 -0.9 1.7 -0.7
Depression (Nagel 2018) 1.6 2.4 6.5 0.2 0.4 -1.7 -1.9 2.5 1.0
Intelligence (Savage-Jansen 2018) 0.4 1.2 4.3 -0.7 0.5 -1.1 -1.0 -0.4 -2.1
Neuroticism (Nagel 2018) 1.1 2.6 4.8 -0.5 1.3 -1.8 -1.7 2.2 -1.7
Schizophrenia (2018) 0.7 1.5 3.6 0.7 -0.3 1.4 0.5 1.7 1.9
Schizophrenia vs Biploar Disorder 0.5 0.7 2.3 -0.5 0.9 -0.3 0.3 -0.7 -1.5
Worry (Nagel 2018) 1.9 3.9 5.7 -2.2 1.4 -2.1 -2.4 2.0 -1.5
Alzheimer’s Disease (in mother) 1.0 1.2 3.6 -0.2 1.9 0.4 0.8 -0.3 -1.6
Alzheimer’s Disease (in father) 0.1 0.1 0.4 -0.1 0.4 -0.6 -0.1 -0.1 0.5
Alzheimer’s Disease (including proxy) 0.4 0.5 2.5 0.1 1.6 -0.5 0.1 -0.5 -0.6
Crohns Disease (2017) 0.3 0.6 2.0 -0.7 -1.4 0.2 -0.0 -0.7 0.5
Irritable Bowel Disease (IBD) 0.2 0.4 1.7 -0.4 -0.6 -0.0 0.3 -1.3 0.0
Ulcerative Colitis (UC) 0.2 0.3 0.9 -0.0 0.6 0.5 1.0 -0.6 -0.5
Major Depression (MDD) 0.1 0.1 0.2 0.0 0.5 0.4 -0.0 0.0 0.2
Reaction Time 0.9 1.8 3.5 -1.3 0.5 1.8 1.4 1.9 -0.2
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.8 -0.9 -0.2 -0.5 -0.1 0.4 -0.8
Breast Cancer 0.3 0.8 1.5 -0.9 -1.1 1.0 1.2 0.4 -0.0
Ovarian Cancer 0.4 0.5 2.2 -0.1 -1.5 0.1 0.1 0.6 0.7
Prostate Cancer 0.9 1.3 3.7 -0.6 1.6 -0.2 0.3 1.9 -1.1
Age at First Birth 1.3 2.0 6.1 2.5 1.6 0.6 0.8 0.5 1.3
Bipolar Disorder (2011) 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 -0.3
Body Mass Index (BMI) (2010) 6.1 8.4 13.0 0.1 -3.6 3.2 3.3 -2.7 3.1
Coronary Artery Disease (CAD) 1.0 1.1 2.5 1.1 1.6 0.2 1.1 0.3 -1.3
Crohns Disease (2012) 0.1 0.2 0.6 0.1 -0.8 -0.1 -0.7 -0.1 0.1
Mean Putamen Volume 0.3 0.4 1.7 -0.4 -0.1 -0.3 -0.4 -0.3 -1.3
Fasting Glucose 0.6 0.7 1.6 -0.1 -1.3 1.1 0.8 -0.8 -0.3
HbA1C 0.3 0.3 0.7 0.2 -0.1 0.8 0.5 -0.6 -0.5
HDL Cholesterol 0.5 0.9 1.9 -0.3 1.3 0.9 1.4 0.4 -0.8
LDL Cholesterol 0.1 0.2 0.3 0.5 -0.3 0.3 0.5 -0.5 -0.2
Lupus 0.5 0.7 1.4 -0.4 -1.2 -0.5 -1.2 -0.4 0.8
Neuroticism (2016) 2.3 3.3 8.2 -1.4 -0.2 -2.2 -2.9 2.0 0.6
Primary Biliary Cirrhosis 0.3 0.4 1.2 0.1 -0.0 0.7 1.1 0.7 -0.5
Rheumatoid Arthritis 1.4 2.0 5.4 -0.6 -0.3 0.9 1.0 2.3 2.0
Schizophrenia (2014) 0.6 1.4 3.7 0.5 0.4 1.3 0.7 1.9 1.4
Triglycerides 0.3 0.5 1.8 -0.0 -1.3 -0.6 -0.1 0.1 0.9
Type 2 Diabetes (T2D) (2012) 2.3 2.7 5.3 0.2 -2.3 2.2 1.9 0.8 1.2
Ulcerative Colitis 0.1 0.2 0.6 -0.6 0.4 0.0 0.1 -0.8 0.1
Blood Eosinophil Count 0.1 0.9 2.8 1.1 0.1 0.1 1.0 1.7 0.2
Blood Platelet Count 0.2 1.9 8.4 0.4 1.0 0.4 1.2 -2.9 0.3
Blood Red Count 0.2 1.8 3.0 1.7 -0.1 1.3 1.7 -1.7 -0.5
Blood White Count 0.4 2.8 5.5 1.0 -2.3 1.8 2.2 0.4 1.6
Heel T-Score 0.2 1.4 4.1 1.3 -2.0 1.0 0.4 -0.1 1.1
BMI 5.5 31.8 79.9 0.8 -8.9 5.7 6.4 -1.7 5.8
Height 0.4 7.5 32.3 -1.9 -1.8 0.8 0.5 -5.7 2.3
Waist Hip Ratio (WHR) 0.2 0.9 3.0 1.4 1.7 -0.4 -0.3 0.2 -0.6
Systolic Blood Pressure 0.4 2.0 5.1 -0.1 -2.2 1.4 1.6 0.9 1.3
Smoking Status 0.6 1.5 3.0 -0.4 -0.8 1.6 1.6 1.7 0.5
Allergy or Eczema 0.4 1.1 2.9 0.1 -0.1 -1.5 -1.7 -1.1 -0.4
Cardiovascular Disease 1.7 5.5 18.2 -0.7 -4.3 2.2 2.8 0.2 1.4
Hypothyroidism (self reported) 0.3 0.8 2.0 1.4 1.2 -1.1 -0.5 -0.0 -0.1
Respiratory disease 0.8 1.8 3.4 -0.9 -1.7 -1.2 -1.5 0.5 1.8
Type 2 Diabetes (T2D) (2018) 1.0 1.8 4.8 0.6 -2.2 1.5 1.7 -0.2 0.6
Lung FEV1/FVC ratio 0.7 3.4 9.6 -0.4 -0.0 2.8 3.1 -1.6 -0.4
Lung FVC 0.2 1.0 2.9 0.4 0.1 -0.6 -1.7 -1.4 -0.7
Neuroticism 1.2 2.9 5.0 -0.1 2.0 -1.6 -1.9 2.2 -1.6
Chronotype (morning person) 0.5 1.1 3.5 -1.9 -0.6 -1.0 0.5 -1.0 -0.7
Hair Pigment 0.1 2.5 6.5 0.4 -2.5 1.0 1.3 -2.0 1.3
Tanning 0.1 1.2 5.0 2.2 0.4 1.0 0.8 0.3 0.5
Hand grip strength (left) 0.8 2.2 4.9 0.6 -0.7 2.2 2.1 -0.1 1.7
Number of treatments/medications taken 1.4 2.5 8.8 -0.4 -3.0 -1.6 -1.1 -0.1 1.4
Average weekly spirits intake 1.0 1.2 2.0 0.1 -1.3 1.3 1.0 1.4 0.9
Sensitivity / hurt feelings 0.7 1.2 3.8 0.2 2.0 0.4 0.8 1.1 -1.1
Frequency of depressed mood in last 2 weeks 1.5 2.1 5.0 -0.3 -0.0 -1.6 -2.2 2.2 0.6
Hearing difficulty/problems: Yes 1.3 1.9 4.0 -1.3 0.6 -2.0 -1.6 -1.6 -0.6
Relative age of first facial hair 1.3 2.8 5.8 -0.8 -0.9 -1.9 -2.4 2.0 -1.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 -1.2 -0.2 -0.9 -0.6 -0.2 -0.7
Ever used hormone-replacement therapy (HRT) 0.7 0.9 4.4 -0.4 -2.1 0.5 0.4 0.1 0.8
Ever had hysterectomy (womb removed) 0.4 0.5 0.9 1.0 -0.5 -0.5 -1.0 0.6 -0.1
Systolic blood pressure, automated reading 1.1 3.3 5.7 -1.5 -2.4 1.4 1.9 1.8 1.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 2.9 1.4 -0.8 1.4 1.7 0.9 0.8
Angina 1.0 1.3 4.5 -0.3 0.2 1.4 2.1 -0.3 -1.0
Medication for hormone replacement therapy 1.2 1.4 4.8 -0.7 -0.9 1.3 2.2 -0.3 -0.6
Vitamin and mineral supplements 2.0 2.7 5.6 -0.1 2.4 -1.1 -0.8 2.0 -2.1
Supplements: Zinc 0.7 0.8 3.5 0.7 -0.8 -0.1 0.3 -1.9 0.1
Medication: Co-codamol 0.5 0.5 1.7 -0.8 -0.8 -0.0 0.0 1.3 0.4
Medication: Metformin 1.0 1.5 3.8 1.9 -1.5 0.5 0.9 -0.8 1.0
Diabetes (father) 2.3 2.9 7.6 0.7 -1.2 2.6 2.8 0.9 0.3
Diabetes (mother) 0.8 1.0 2.6 -1.0 1.0 -1.3 -1.6 0.0 0.1
Severe depression (siblings) 0.4 0.4 1.0 -0.2 0.9 0.2 0.1 0.7 -1.0
Pack years adult smoking proportion 1.5 2.3 4.8 0.5 1.5 -2.2 -1.3 -1.5 -1.6
Impedance of leg (right) 2.0 9.8 21.0 -0.2 4.6 -3.3 -3.7 2.5 -2.6
Leg fat-free mass (left) 3.9 20.8 53.0 0.0 -7.3 3.8 4.1 -4.3 4.6
Trunk fat percentage 2.8 11.4 35.7 0.2 -6.0 2.8 2.9 -2.4 3.1
Hand grip strength (right) 1.2 3.4 7.5 -0.7 -1.4 2.7 2.7 -0.9 1.5
Townsend deprivation index at recruitment 0.8 1.1 2.4 1.2 -1.5 0.2 -0.7 0.2 1.5
Current tobacco smoking 0.7 1.1 4.8 1.2 -0.1 0.2 0.4 2.2 0.2
Average weekly fortified wine intake 1.1 1.3 3.8 0.8 0.4 1.1 0.9 -1.9 1.0
Maternal smoking around birth 0.2 0.4 1.2 1.1 0.2 0.2 0.6 0.0 -0.7
Fed-up feelings 0.3 0.5 1.3 0.4 0.7 -0.6 -0.4 1.1 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 10.5 0.8 1.0 -0.7 -1.0 3.2 0.8
Relative age voice broke 0.2 0.3 0.6 -0.4 -0.7 0.3 -0.3 0.8 -0.6
Taking other prescription medications 1.8 2.8 8.8 0.4 -3.0 -1.1 -1.2 1.9 1.2
Age when periods started (menarche) 0.8 2.0 6.0 -1.0 0.2 -0.7 -2.1 2.5 0.5
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.6 -0.4 -0.3 -0.1 -0.2 0.8 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 9.0 0.2 -3.0 -0.4 -0.9 -1.9 0.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 3.5 0.2 -0.1 -0.2 -0.5 -0.6 -1.9
Qualifications: CSEs or equivalent 1.7 2.2 5.6 1.4 -2.0 -0.7 -1.1 -0.2 2.4
Serious illness, injury or assault to yourself 1.9 2.3 3.1 -1.5 -1.6 -1.8 -1.6 -1.7 0.6
High blood pressure 2.2 6.1 16.6 -1.5 -4.1 2.4 2.8 -0.3 2.0
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.5 1.4 -0.8 -1.3 -1.9 -1.2 0.4
Multivitamins +/- minerals 2.9 3.7 11.2 -0.5 -3.3 1.1 0.6 -2.6 1.6
Stomach or abdominal pain in last month 0.6 0.7 1.7 0.3 -0.6 -1.1 -1.3 -0.5 0.8
Supplements: Glucosamine 3.5 4.6 7.2 2.2 -1.6 2.7 2.6 -0.2 2.4
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.5 -1.3 -1.7 -0.0 -0.0 -1.9 -0.8
Medication: Atenolol 1.8 2.2 5.2 0.4 -0.9 2.1 2.3 1.6 0.3
Medication: Levothyroxine sodium 0.5 0.8 4.0 2.0 0.4 -0.3 -0.2 0.1 -0.5
Sitting height 0.3 2.1 8.0 -1.8 -0.6 -0.3 -0.1 -2.8 0.9
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 0.3 -0.6 -0.0 0.1 0.5 0.8
High blood pressure (mother) 1.4 2.0 6.1 -0.1 -2.5 1.2 1.7 -0.9 0.5
Body mass index (BMI) 4.7 20.2 53.1 -0.4 -7.3 4.6 5.0 -2.2 4.1
Impedance of leg (left) 2.6 12.6 27.8 -0.6 5.3 -3.8 -4.2 2.4 -3.2
Leg predicted mass (left) 3.9 20.7 52.0 0.0 -7.2 3.9 4.2 -4.3 4.7
Trunk fat mass 4.0 17.1 48.4 -0.1 -7.0 3.6 3.8 -3.0 4.2
Waist circumference 4.3 15.6 38.8 -0.2 -6.2 3.8 4.2 -2.3 4.2
Number of incorrect matches in round 3.1 5.2 15.8 0.5 -2.2 2.9 1.3 0.4 4.0
Past tobacco smoking 0.6 1.1 1.7 -0.0 1.3 -1.0 -1.1 -0.9 -1.3
Alcohol usually taken with meals 0.1 0.1 0.5 -0.0 -0.1 0.4 0.2 -0.7 0.4
Nervous feelings 0.8 1.5 3.3 -1.8 1.1 -1.1 -1.7 0.4 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.2 -0.2 -0.1 -1.4 -1.5 1.3 -0.3
Hearing difficulty/problems with background noise 2.0 3.2 6.6 -2.6 1.9 -2.2 -1.7 -0.4 -1.1
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 -0.8 0.5 -0.1 -0.3 0.8 -0.7
Had menopause 1.5 1.8 3.2 -0.7 -1.5 1.7 1.8 0.6 1.3
Had other major operations 1.9 2.3 4.3 -0.7 -0.0 -2.1 -2.1 -1.8 -1.3
Forced vital capacity (FVC) 0.3 1.2 4.7 -0.4 -0.6 -0.7 -1.1 -2.2 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.5 0.6 -1.9 -0.8 -1.1 -1.5 -0.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.5 1.2 -0.0 -0.1 -0.1 1.0 0.6
Qualifications: None of the above 0.4 0.9 2.4 0.1 -1.0 1.2 1.5 0.8 -0.2
Financial difficulties in last 2 years 1.2 1.7 4.3 -0.8 -1.0 0.2 -0.2 2.1 2.0
Mouth/teeth dental problems 0.6 0.8 1.9 -1.4 0.6 0.2 -0.6 -0.9 -1.3
Heart attack 1.6 2.0 7.0 0.2 0.0 1.4 1.8 2.6 -0.1
Allergy 1.1 2.5 4.3 -2.0 1.4 1.9 2.1 0.7 -0.9
Pain all over the body in last month 1.3 1.4 4.5 -0.4 -0.5 -1.2 -1.3 -2.1 -0.7
Diabetes (self-reported) 0.5 0.8 1.9 1.2 -0.8 0.9 1.4 0.1 0.3
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.9 0.0 0.8 -1.7 -1.6 0.1 -0.4
Medication: Ramipril 0.3 0.4 1.0 -1.0 0.2 0.5 0.9 0.3 -0.5
Medication: Simvastatin 1.8 2.6 5.2 0.7 -1.9 1.4 0.8 2.3 1.8
Fluid intelligence score 0.2 0.4 2.0 -1.4 0.0 0.0 0.4 -0.1 -0.7
Illnesses of siblings 1.5 2.0 7.6 -0.1 1.4 -1.5 -2.8 -0.5 0.5
Neuroticism score 1.2 2.5 4.0 -0.4 1.9 -1.8 -2.0 1.5 -1.2
Weight 4.6 22.8 58.5 -0.7 -7.7 4.2 4.5 -3.8 5.0
Impedance of arm (right) 1.6 7.4 14.0 1.1 3.7 -2.9 -3.7 1.0 -2.5
Arm fat percentage (right) 3.6 14.3 45.9 -0.2 -6.8 3.5 3.6 -1.7 3.4
Trunk fat-free mass 2.3 13.2 28.0 -1.1 -5.3 3.4 3.5 -3.0 4.2
Hip circumference 4.1 17.9 51.7 -1.1 -7.2 3.9 3.8 -2.5 4.2
Time employed in main current job 1.9 2.2 4.8 -0.6 -0.0 1.8 2.2 1.5 -1.5
Alcohol intake versus 10 years previously 0.5 0.7 1.3 0.8 -0.9 0.9 1.1 -0.8 -0.5
Father’s age at death 0.8 1.0 2.1 -1.2 -1.1 -0.2 -1.1 -0.3 1.4
Worrier / anxious feelings 0.9 1.6 4.3 -1.1 0.6 -1.5 -2.1 1.1 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.8 1.4 0.1 -0.9 -0.9 0.9 0.0
Falls in the last year 0.3 0.4 0.8 -0.5 0.5 -0.8 -0.6 -0.9 -0.6
Hair/balding pattern: Pattern 3 0.3 0.5 1.7 -0.7 1.3 -0.2 0.1 -0.8 -0.4
Number of live births 0.6 0.8 2.0 -1.4 0.7 -1.1 -1.0 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 9.7 -0.7 -0.2 -0.6 -0.6 -3.1 -0.6
Pulse rate 0.3 0.4 1.3 -0.1 -1.1 -0.0 0.5 -1.0 0.2
Happiness 0.7 0.8 2.7 -0.5 1.1 0.9 0.4 1.6 0.2
Noisy workplace 0.5 0.6 1.6 -0.0 1.3 -0.5 0.4 -0.7 -1.0
Qualifications: A levels/AS levels or equivalent 0.4 0.9 3.8 0.4 -0.2 -0.7 -0.8 -2.0 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.0 1.4 -0.6 -0.7 -1.2 -0.8 -0.8
Mouth/teeth dental problems: Dentures 1.5 2.6 7.7 0.6 -0.3 2.1 2.8 1.6 0.2
Asthma 0.6 1.2 2.2 -0.1 -1.3 -1.1 -1.5 0.5 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 4.2 2.0 -0.7 -2.1 -1.6 -0.4 0.6
Medication: Cholesterol lowering 0.9 1.5 3.1 -0.3 -1.8 1.6 1.7 0.1 0.5
Depression (self-reported) 0.8 1.0 1.8 0.9 0.6 -1.3 -1.3 1.0 -0.6
Medication: Lansoprazole 0.3 0.3 0.8 -0.9 -0.8 -0.2 -0.1 0.5 -0.3
Prospective memory result 0.8 1.0 2.1 0.5 -1.4 1.0 0.9 -0.1 1.4
Lung cancer (father) 0.9 1.1 2.1 1.1 0.8 -1.5 -1.3 -0.2 -0.8
Illnesses of mother 0.5 0.7 2.1 1.2 1.5 0.5 0.0 0.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 11.6 -0.1 -0.3 -0.6 -0.8 -3.4 0.5
Pulse wave Arterial Stiffness index 0.7 0.8 1.9 -0.8 -0.6 -1.4 -1.2 -0.1 0.5
Impedance of arm (left) 2.1 9.7 19.5 1.2 4.0 -3.7 -4.4 0.4 -2.7
Arm fat mass (right) 4.5 18.7 52.1 -0.3 -7.2 4.2 4.4 -2.3 4.2
Trunk predicted mass 2.3 13.4 28.3 -1.1 -5.3 3.4 3.5 -3.0 4.3
Standing height 0.4 4.1 15.9 -0.7 -1.6 -0.2 -0.6 -4.0 2.3
Length of working week for main job 0.4 0.5 1.2 0.4 0.5 0.7 1.1 0.1 -0.9
Exposure to tobacco smoke at home 0.7 0.8 2.1 -0.3 0.7 0.9 1.5 0.9 -0.3
Breastfed as a baby 1.6 2.0 4.0 1.0 -0.0 2.0 1.4 1.9 1.2
Tense / ‘highly strung’ 1.6 2.6 7.0 -2.6 1.6 -0.9 -1.0 1.7 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.8 11.1 1.1 1.8 -1.6 -2.0 3.3 -0.6
Hair/balding pattern: Pattern 4 0.9 2.1 6.2 1.2 -2.5 0.9 1.1 -0.2 1.7
Birth weight of first child 0.5 0.8 3.1 1.1 -1.7 -0.4 -0.7 -0.1 0.3
Peak expiratory flow (PEF) 0.5 1.1 5.3 -0.1 -1.1 0.2 0.4 -2.3 -0.2
Pulse wave reflection index 0.3 0.4 1.1 0.7 -0.1 -1.0 -0.8 -0.1 -0.4
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.0 0.5 0.8 -0.2 0.1 1.7 -1.6
Loud music exposure frequency 0.6 0.6 1.8 0.2 0.8 -1.0 0.1 -1.3 -0.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.7 0.6 -0.1 -1.1 -1.3 -0.7 0.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 5.5 -0.1 1.9 -2.4 -1.3 0.0 -1.2
Blood clot in the leg (DVT) 1.0 1.3 3.2 0.0 -1.8 -1.1 -1.4 0.1 1.2
Medication: Paracetamol 0.7 1.1 2.0 0.8 -1.1 -1.4 -1.4 0.5 0.9
Headache pain in last month 0.7 1.3 4.7 0.9 0.4 -0.5 -0.4 2.2 1.2
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 6.0 1.1 2.5 -0.8 -1.0 0.0 -0.5
Glaucoma (self-reported) 1.3 1.5 4.8 -0.1 0.5 -1.6 -0.8 -2.2 -0.9
Gout (self-reported) 0.9 1.2 4.5 0.1 -2.1 0.5 0.7 0.1 1.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.0 1.4 1.2 -1.4 -1.0 -0.2 -0.7
Medication: Amlodipine 0.3 0.4 1.1 -0.4 -1.1 -0.3 -0.4 -0.3 0.8
Medication: Ventolin 100micrograms inhaler 1.3 1.6 3.5 0.5 -0.6 1.7 1.9 1.4 0.9
Birth weight 0.3 0.6 1.6 -1.0 1.2 -0.3 0.6 0.7 -0.5
Chronic bronchitis/emphysema (mother) 1.4 1.6 8.5 0.8 -0.5 -0.0 -0.4 2.9 0.5
High blood pressure (siblings) 2.5 3.6 8.0 -0.3 -2.5 2.3 2.8 1.2 1.0
Forced vital capacity (FVC), Best measure 0.7 2.4 8.3 0.3 -0.8 -1.1 -1.7 -2.9 1.1
Body fat percentage 3.3 12.9 40.4 -0.1 -6.4 3.1 3.2 -2.2 3.5
Leg fat percentage (right) 3.8 13.7 40.4 -0.7 -6.4 3.5 3.7 -1.1 3.8
Arm fat-free mass (right) 2.7 13.9 31.7 -0.9 -5.6 3.2 3.6 -3.5 4.0
Exposure to tobacco smoke outside home 1.3 1.7 5.0 -1.2 2.2 -0.2 0.7 0.1 -1.9
Comparative body size at age 10 3.9 10.9 32.2 1.0 -5.7 3.2 3.1 -2.2 2.7
Number of full brothers 1.1 1.4 2.6 -1.6 -1.4 -1.4 -1.1 -0.8 0.2
Worry too long after embarrassment 0.8 1.4 2.0 -1.4 1.0 -1.2 -1.4 0.5 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 4.6 -1.0 1.5 -2.1 -2.1 0.4 -0.1
Wheeze or whistling in the chest in last year 0.7 1.2 2.4 0.5 -1.6 0.8 1.4 0.8 1.1
Number of children fathered 2.1 2.4 5.1 0.7 2.3 -1.8 -1.7 0.6 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.4 5.3 -2.3 -1.8 1.6 1.1 -1.4 -0.4
Age at first live birth 0.4 0.8 1.5 -0.2 0.7 0.7 1.0 -1.2 1.1
Pulse wave peak to peak time 0.5 0.6 1.8 0.7 0.4 1.3 1.1 -0.4 -0.3
Health satisfaction 0.3 0.4 1.5 -0.1 -0.1 -0.8 -0.3 -0.3 -1.2
Shortness of breath walking on level ground 0.3 0.4 1.4 -0.6 -1.2 -0.2 0.2 -0.1 0.7
Qualifications: College or University degree 0.4 1.2 2.4 -1.4 1.3 0.9 0.6 -0.3 -1.5
Eye problems/disorders: None of the above 0.8 0.9 1.7 -0.9 0.4 1.3 1.2 1.0 -0.1
Mouth/teeth dental problems: Loose teeth 1.1 1.3 4.7 2.2 0.2 -1.2 -0.8 -0.4 1.0
Emphysema/chronic bronchitis 0.7 0.8 1.8 1.4 0.3 0.1 1.1 0.5 -1.1
Medication for pain relief, constipation, heartburn 0.5 0.9 3.1 -1.1 1.8 0.8 0.5 -0.1 -0.4
Neck or shoulder pain in last month 1.2 1.7 4.0 2.0 -0.8 0.6 0.5 1.7 1.4
Medication: Blood pressure 1.5 2.7 11.2 -1.0 -3.3 1.3 1.2 -0.5 0.8
Angina (self-reported) 1.0 1.3 4.5 -0.4 -0.1 1.6 2.1 -0.1 -0.8
Migraine (self-reported) 0.5 0.7 2.7 -1.6 -0.0 -0.1 -0.2 0.9 -0.7
Medication: Ibuprofen 1.8 2.2 6.6 1.2 -0.8 -2.6 -2.1 -0.5 0.0
Medication: Allopurinol 0.5 0.7 2.0 -0.3 -1.4 0.8 1.0 0.6 0.3
Medication: Omeprazole 1.9 2.3 5.4 0.0 -2.3 1.8 1.9 0.8 0.9
Medication: Seretide 50 evohaler 1.7 2.0 4.3 -1.5 -1.1 1.5 2.1 0.2 1.4
Mean time to correctly identify matches 1.1 2.0 4.0 -1.5 -0.2 2.0 1.6 1.9 0.0
Heart disease (mother) 2.7 3.2 14.7 0.0 -3.8 -0.1 0.2 -1.2 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.2 5.5 -0.7 1.2 2.1 2.3 1.1 0.0
Whole body fat mass 4.5 19.0 52.7 -0.1 -7.3 4.0 4.3 -2.7 4.4
Leg fat mass (right) 5.3 20.5 58.9 -0.4 -7.7 4.1 4.4 -2.5 4.6
Arm predicted mass (right) 2.8 14.3 31.2 -0.8 -5.6 3.4 3.8 -3.4 4.1
Pulse rate, automated reading 0.1 0.4 1.0 0.5 -0.6 0.6 1.0 0.1 0.7
Alcohol intake frequency. 0.5 1.1 3.4 -0.3 0.3 0.9 1.2 -1.8 -0.9
Comparative height size at age 10 0.7 4.1 20.5 -0.5 -1.4 0.0 0.4 -4.5 1.3
Number of full sisters 0.6 0.7 2.0 1.1 -0.7 0.1 -0.3 -1.4 -0.8
Suffer from ‘nerves’ 2.2 3.4 7.2 -0.9 2.0 -2.3 -2.7 0.8 -1.7
Overall health rating 0.7 1.4 5.7 0.3 -2.4 -0.3 -0.4 1.0 1.2
Chest pain or discomfort 1.3 1.9 3.4 -1.8 -1.0 1.2 1.5 1.9 -0.2
Had major operations 2.2 2.6 5.3 0.8 -2.3 1.6 1.3 2.1 0.9
Age at last live birth 0.5 0.7 2.4 -0.4 -0.1 1.0 0.7 -0.2 1.6
Family relationship satisfaction 0.4 0.5 1.5 1.2 1.1 0.1 0.4 0.6 0.2
Leg pain on walking 0.6 0.8 1.2 0.0 -1.1 0.9 1.1 0.8 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.2 0.6 -0.7 -0.5 0.1 -0.2
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.6 0.8 -0.3 -0.2 0.0 -0.3 0.8
Illness, injury, bereavement, stress in last 2 years 2.2 2.6 7.1 -1.1 2.7 0.7 1.2 1.3 -1.9
Medication: Aspirin 2.3 3.1 5.5 0.4 -2.2 2.1 2.4 -0.3 1.9
Supplements: Vitamin C 1.5 1.8 5.5 -0.6 -1.1 0.3 0.1 -1.9 2.3
Knee pain experienced in last month 0.7 1.0 2.8 1.4 -1.7 -0.2 -0.8 -0.1 0.8
Hypertension (Self-reported) 2.1 5.8 13.9 -1.4 -3.7 2.5 2.8 0.1 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.1 3.7 8.2 -1.0 -2.9 2.0 1.8 -0.8 2.2
Illnesses of father: Heart disease 0.7 1.0 2.5 0.0 -1.6 -0.1 -0.1 1.1 1.5
Illnesses of siblings: Diabetes 0.5 0.6 2.2 0.1 -0.1 0.9 1.5 -0.6 -0.5
Smoking status: Previous 0.6 0.8 2.2 0.2 -1.5 0.9 0.7 -0.2 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 9.4 -0.0 0.4 -1.0 -1.0 -3.1 0.1
Whole body fat-free mass 3.0 17.1 40.3 -0.6 -6.3 3.7 3.8 -3.7 4.5
Leg fat-free mass (right) 3.3 17.6 42.8 -0.2 -6.5 3.5 3.8 -4.4 4.1
Arm fat percentage (left) 3.4 13.5 43.8 0.1 -6.6 3.3 3.4 -2.1 3.3
Average weekly red wine intake 1.1 1.6 3.9 0.9 -2.0 0.4 -0.3 -1.7 1.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 3.4 0.7 0.5 -0.0 0.2 1.9 0.1
Mood swings 0.6 1.1 2.2 0.9 0.2 -1.5 -1.2 0.7 -1.2
Loneliness, isolation 1.1 1.5 3.3 1.4 0.8 -1.4 -1.8 1.0 -0.0
Long-standing illness, disability or infirmity 0.7 1.1 1.6 -0.9 -1.2 -1.1 -1.3 -1.0 -0.6
Ever had bowel cancer screening 0.4 0.5 1.6 0.7 -0.1 -0.1 -0.5 1.3 0.6
Diabetes diagnosed by doctor 0.3 0.4 1.0 1.0 -0.9 0.2 0.6 -0.5 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 1.0 -0.5 1.0 0.0 -0.1 0.3 0.5
Friendships satisfaction 0.4 0.5 1.5 0.7 1.2 -0.5 -0.2 -0.9 -0.3
Qualifications: nursing, teaching 0.6 0.9 3.0 -0.8 -0.7 1.7 1.1 -0.3 -0.1
Commuting to job workplace: Walk 0.5 0.6 1.4 -0.6 -0.7 -0.4 -1.2 -0.9 0.4
Eye problems/disorders: Cataract 0.2 0.3 0.8 -0.0 -0.1 -0.8 -0.9 0.1 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.0 2.0 -0.9 -0.7 -0.3 0.2 1.0
Medication for cholesterol 0.9 1.4 2.3 1.2 1.5 -1.3 -1.4 -0.9 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 8.3 -1.5 -2.9 0.4 0.0 -0.0 1.3
Back pain experienced in last month 0.3 0.5 1.1 0.7 -0.4 0.2 0.2 1.1 1.0
Mineral and other dietary supplements 1.9 2.5 5.5 0.4 1.9 -1.1 -1.0 1.9 -2.3
Breast cancer (self-reported) 0.5 0.6 1.5 1.2 -1.1 -0.3 -0.3 -0.5 -0.6
Asthma (self-reported) 0.9 1.7 3.5 -0.4 -1.8 -1.1 -1.3 0.6 1.9
Osteoporosis (self-reported) 1.7 2.1 3.7 0.9 1.5 -1.9 -1.6 -0.0 -1.9
Osteoarthritis (self-reported) 0.3 0.4 1.4 -0.1 -0.2 -0.6 -0.1 -0.7 -1.2
Medication: Aspirin 1.2 1.6 2.9 0.3 -1.7 1.1 1.6 -1.1 1.3
Medication: Gliclazide 1.8 2.1 3.7 1.7 -1.9 1.5 0.9 -0.2 1.6
Illnesses of father: None of the above (group 1) 1.0 1.2 5.4 -0.0 2.3 0.1 0.3 -1.2 -0.7
Smoking status: Current 0.6 1.0 5.1 0.6 0.2 0.4 0.7 2.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 3.0 -0.1 0.3 -0.6 -0.7 -1.7 -1.0
Whole body water mass 3.0 17.3 40.8 -0.6 -6.4 3.7 3.8 -3.7 4.6
Leg predicted mass (right) 3.3 17.7 43.2 -0.2 -6.6 3.5 3.8 -4.3 4.2
Arm fat mass (left) 4.5 18.5 50.6 -0.3 -7.1 4.1 4.4 -2.4 4.3
Number of self-reported non-cancer illnesses 0.6 1.0 4.7 -0.8 -2.2 -0.7 -0.1 -0.3 0.3
Average weekly champagne plus white wine intake 1.4 1.9 4.0 2.0 -1.3 0.9 0.1 -0.8 2.0
Miserableness 1.0 1.8 3.8 1.2 1.4 -0.3 -0.4 1.9 -1.8
Guilty feelings 0.6 0.8 1.5 1.2 0.5 -1.0 -1.2 1.0 0.0
Wears glasses or contact lenses 0.3 0.4 1.4 0.2 -0.8 0.2 0.1 1.2 0.5
Ever taken oral contraceptive pill 0.3 0.4 1.4 0.0 -0.2 0.2 0.2 0.9 1.2
Hearing aid user 1.9 2.1 4.1 0.8 -0.3 -1.8 -1.8 -2.0 -1.3
Mother’s age at death 1.1 1.4 2.7 -1.1 1.0 1.4 1.6 0.6 -1.0
Financial situation satisfaction 0.9 1.1 2.7 -0.5 1.0 -1.2 -0.8 -0.5 -1.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.5 -1.1 -0.3 0.1 0.3 -1.9 0.7
Commuting to job workplace: Public transport 0.4 0.5 1.8 0.5 -1.3 0.9 0.3 0.2 0.3
Eye problems/disorders: Glaucoma 1.3 1.6 7.7 -0.3 0.1 -1.0 -0.8 -2.8 -0.3
Medication: Blood pressure 0.4 0.8 2.5 -1.6 -1.1 0.5 0.5 -0.4 0.5
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.7 0.2 -1.3 0.6 0.7 1.2 0.1
Supplements: Fish oil (including cod liver oil) 2.9 3.7 8.8 -1.1 -1.9 2.2 1.9 -0.3 3.0
High cholesterol (Self-reported) 1.4 2.5 6.2 0.0 -2.5 1.8 1.5 0.9 1.4
Medication: Bendroflumethiazide 0.5 0.7 1.5 -0.9 -0.7 1.0 1.2 -0.3 0.7
Medication: Paracetamol 1.1 1.6 3.8 0.6 -1.4 -2.0 -1.7 0.2 0.8
Medication: Lisinopril 2.6 3.4 8.5 -1.2 -2.9 2.1 1.9 0.5 1.5
Medication: Atorvastatin 1.4 1.7 5.1 -1.5 -0.7 1.5 2.3 0.0 -0.5
Illnesses of father: High blood pressure 0.4 0.6 1.6 -0.2 -0.4 0.2 0.1 1.3 -1.2
Alcohol drinker status: Never 1.3 1.6 3.7 -1.1 1.7 0.6 1.0 -0.4 -1.9
Ever smoked 0.6 1.0 2.6 0.6 -0.8 0.6 0.7 1.6 1.3
Basal metabolic rate 3.4 19.0 46.2 -0.7 -6.8 3.9 4.0 -3.8 4.7
Leg fat percentage (left) 3.4 12.3 38.1 -1.0 -6.2 3.1 3.3 -1.1 3.6
Arm fat-free mass (left) 3.5 17.5 40.7 -0.9 -6.4 4.0 4.0 -2.8 4.8
Number of operations (self-reported) 0.3 0.5 2.0 -0.2 -1.4 0.4 0.4 0.5 -0.4
Average weekly beer plus cider intake 0.3 0.4 1.0 0.4 0.4 0.5 0.9 -0.0 -1.0
Irritability 2.4 4.1 9.9 0.6 2.4 -2.0 -1.5 1.4 -3.1
Risk taking 0.6 0.9 1.7 1.3 0.2 1.2 1.0 0.7 -0.7
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 0.9 0.0 0.1 -0.0 0.4 1.1
Fractured/broken bones in last 5 years 0.7 0.9 1.7 -0.7 0.5 -1.2 -1.3 -0.9 -1.0
Age started oral contraceptive pill 0.2 0.2 0.7 -0.1 -0.7 -0.2 -0.8 -0.3 0.2
Diastolic blood pressure, automated reading 0.7 2.0 4.4 -0.7 -2.0 1.6 2.1 0.6 0.7
Ever depressed for a whole week 0.3 0.3 0.9 0.5 -0.1 -0.9 -0.6 0.4 0.4
Unable to work because of sickness or disability 0.8 1.0 2.7 -0.4 -0.2 -1.6 -1.4 -0.9 -0.2
Commuting to job workplace: Cycle 1.2 1.5 5.0 -0.3 0.7 -1.8 -2.2 0.2 0.3
Myopia 1.0 1.4 3.7 -1.0 0.9 -1.4 -1.0 0.6 -1.9
Vascular/heart problems diagnosed by doctor 1.7 4.5 11.0 1.4 3.3 -2.2 -2.8 -0.0 -1.3
Cholesterol lowering medication 0.4 0.6 1.5 0.2 -1.2 0.8 0.7 0.7 0.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.2 -0.9 -0.8 0.9 1.1 0.3 -0.0
Pain experienced in last month 1.3 2.1 6.9 -2.6 1.5 0.3 0.3 -0.6 -1.7
Supplements: Calcium 0.9 1.0 3.5 0.9 0.1 -0.6 -1.1 -1.9 0.0
Basal cell carcinoma (self-reported) 0.4 0.5 1.0 0.7 -0.6 -0.6 -0.7 -0.1 1.0
Heart attack/myocardial infarction (self-reported) 1.3 1.6 6.2 -0.1 0.0 1.1 1.5 2.5 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.2 0.2 -1.5 -1.2 -1.5 -0.1 0.7
Heart disease (siblings) 0.6 0.8 2.2 1.2 0.4 0.4 1.5 -0.6 -0.6
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.2 0.1 0.3 0.4 0.4 0.2
Pack years of smoking 1.3 1.9 3.4 0.4 1.6 -1.8 -1.0 -1.0 -1.8
Impedance of whole body 2.5 12.7 25.4 0.5 5.0 -4.1 -4.6 1.1 -3.5
Leg fat mass (left) 5.0 19.5 57.3 -0.6 -7.6 3.9 4.2 -2.5 4.5
Arm predicted mass (left) 3.2 16.3 38.7 -0.8 -6.2 3.8 3.9 -2.8 4.6