Hub : Genes

CTD-2561B21.4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0644 0.0249 8.0e-04 0.036 NA 0.034 NA 0.035 1.8e-04 NA 2.5e-04 NA 2.3e-04
2 GTEx Skin Not Sun Exposed Suprapubic 0.1920 0.0530 3.2e-06 0.056 NA 0.106 NA 0.092 5.3e-04 NA 2.1e-06 NA 9.2e-06
3 GTEx Skin Sun Exposed Lower leg 0.0990 0.0320 2.2e-04 0.090 NA 0.096 NA 0.095 6.9e-08 NA 2.6e-08 NA 2.9e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.7 1.9 -0.0 1.4 0.6
Bipolar Disorder or Schizophrenia 1.0 2.4 6.3 -0.1 2.5 0.9
Depressed Affect (Nagel 2018) 0.7 1.6 2.6 1.2 -1.6 -0.9
Depression (Nagel 2018) 1.6 2.5 3.6 1.4 -1.3 -1.9
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.8 0.8 -1.3 -0.7
Neuroticism (Nagel 2018) 1.2 2.9 4.4 1.3 -2.1 -1.6
Schizophrenia (2018) 0.8 1.7 4.5 -0.2 2.1 0.7
Schizophrenia vs Biploar Disorder 0.6 0.8 1.1 1.0 -1.1 0.4
Worry (Nagel 2018) 1.8 3.8 5.3 1.0 -2.2 -2.3
Alzheimer’s Disease (in mother) 0.5 0.6 1.2 1.1 -0.0 0.8
Alzheimer’s Disease (in father) 0.5 0.5 0.9 0.8 -0.9 0.0
Alzheimer’s Disease (including proxy) 0.6 0.8 2.1 1.4 -0.6 0.1
Crohns Disease (2017) 0.2 0.5 0.9 -1.0 0.8 0.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.2 -0.1 0.1 0.4
Ulcerative Colitis (UC) 0.3 0.6 1.0 1.0 0.1 0.8
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.6 1.1 1.6 -0.2 1.3 1.3
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.2 0.4 -1.1 -0.1
Breast Cancer 0.6 1.4 2.5 -1.6 0.5 1.2
Ovarian Cancer 0.1 0.1 0.1 -0.3 -0.3 -0.0
Prostate Cancer 1.7 2.4 6.5 2.5 -0.8 0.2
Age at First Birth 0.3 0.5 0.7 0.8 0.4 0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 6.9 9.4 12.2 -3.5 2.2 3.3
Coronary Artery Disease (CAD) 0.7 0.8 1.6 1.3 0.1 0.9
Crohns Disease (2012) 0.4 0.7 1.1 -1.1 0.8 -0.6
Mean Putamen Volume 0.1 0.1 0.1 0.2 -0.2 -0.4
Fasting Glucose 0.7 0.8 1.0 -1.0 0.7 1.0
HbA1C 0.2 0.2 0.3 -0.4 0.4 0.6
HDL Cholesterol 0.7 1.1 2.5 0.9 0.0 1.6
LDL Cholesterol 0.1 0.2 0.3 0.1 0.5 0.4
Lupus 0.4 0.6 1.0 -0.8 0.2 -1.0
Neuroticism (2016) 2.6 3.7 9.4 -0.0 -1.3 -3.1
Primary Biliary Cirrhosis 0.3 0.4 1.1 -0.1 0.4 1.1
Rheumatoid Arthritis 0.3 0.4 0.9 -0.3 0.5 1.0
Schizophrenia (2014) 0.6 1.3 3.0 0.7 1.7 0.6
Triglycerides 0.3 0.4 1.0 -1.0 -0.4 -0.3
Type 2 Diabetes (T2D) (2012) 4.1 4.7 6.5 -2.5 1.8 2.1
Ulcerative Colitis 0.0 0.1 0.1 0.3 0.3 -0.0
Blood Eosinophil Count 0.1 0.7 1.0 0.5 -0.9 1.0
Blood Platelet Count 0.1 1.0 2.0 1.0 -0.1 1.4
Blood Red Count 0.1 1.2 3.4 0.2 0.6 1.8
Blood White Count 0.4 3.0 5.7 -1.4 1.1 2.4
Heel T-Score 0.4 3.2 6.8 -2.6 1.5 0.6
BMI 8.0 46.5 66.3 -8.1 5.4 6.6
Height 0.1 1.0 2.3 -1.5 0.6 0.5
Waist Hip Ratio (WHR) 0.1 0.6 1.5 1.2 -0.4 -0.2
Systolic Blood Pressure 0.3 1.5 2.0 -0.8 1.4 1.4
Smoking Status 0.6 1.3 2.1 -0.4 1.5 1.3
Allergy or Eczema 0.5 1.4 3.2 -0.3 -0.9 -1.8
Cardiovascular Disease 1.4 4.8 6.2 -2.1 2.0 2.5
Hypothyroidism (self reported) 0.3 0.7 1.1 1.0 -0.9 -0.4
Respiratory disease 0.6 1.3 2.6 -0.8 -0.7 -1.6
Type 2 Diabetes (T2D) (2018) 1.4 2.6 3.1 -1.8 1.5 1.6
Lung FEV1/FVC ratio 0.9 4.7 9.9 -0.2 2.0 3.1
Lung FVC 0.3 1.4 3.4 -0.7 0.6 -1.9
Neuroticism 1.1 2.6 3.9 1.1 -2.0 -1.6
Chronotype (morning person) 0.9 2.1 5.8 0.0 -2.4 0.6
Hair Pigment 0.1 3.1 6.8 -2.6 0.2 1.5
Tanning 0.1 0.7 1.0 0.6 1.0 0.8
Hand grip strength (left) 1.2 3.1 4.7 -1.1 1.8 2.2
Number of treatments/medications taken 0.9 1.6 2.1 -1.5 -1.1 -1.2
Average weekly spirits intake 1.0 1.2 1.8 -0.9 1.3 1.0
Sensitivity / hurt feelings 0.3 0.6 1.2 0.4 -0.6 1.1
Frequency of depressed mood in last 2 weeks 1.7 2.3 5.6 0.9 -0.8 -2.4
Hearing difficulty/problems: Yes 2.4 3.7 7.3 1.0 -2.7 -1.7
Relative age of first facial hair 1.5 3.0 8.3 0.2 -0.8 -2.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.1 0.5 -1.0 -0.7
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.5 -1.6 1.0 0.5
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 -1.1 -0.2 -1.0
Systolic blood pressure, automated reading 0.4 1.2 3.0 -0.5 0.7 1.7
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 3.0 -0.8 0.8 1.7
Angina 1.2 1.6 4.0 0.5 0.8 2.0
Medication for hormone replacement therapy 1.7 1.9 4.7 -0.4 0.9 2.2
Vitamin and mineral supplements 2.0 2.8 5.7 2.4 -1.1 -1.2
Supplements: Zinc 0.3 0.3 0.4 -0.6 -0.4 0.6
Medication: Co-codamol 0.1 0.1 0.4 -0.6 -0.0 0.1
Medication: Metformin 0.5 0.7 1.2 -0.9 0.3 1.1
Diabetes (father) 2.7 3.4 7.2 -0.4 1.7 2.7
Diabetes (mother) 1.3 1.7 2.8 1.2 -1.0 -1.7
Severe depression (siblings) 0.2 0.2 0.4 0.6 0.4 0.1
Pack years adult smoking proportion 2.3 3.5 6.8 1.6 -2.6 -1.1
Impedance of leg (right) 3.0 14.6 21.0 4.6 -2.9 -3.8
Leg fat-free mass (left) 4.6 24.5 41.6 -6.5 3.8 4.2
Trunk fat percentage 4.0 15.8 28.4 -5.3 3.1 3.1
Hand grip strength (right) 1.8 5.0 7.4 -1.9 2.0 2.7
Townsend deprivation index at recruitment 0.8 1.1 1.7 -1.0 1.3 -0.9
Current tobacco smoking 0.1 0.2 0.4 0.3 -0.6 0.3
Average weekly fortified wine intake 0.3 0.4 0.9 -0.3 0.4 0.9
Maternal smoking around birth 0.1 0.1 0.2 0.1 -0.3 0.5
Fed-up feelings 0.3 0.5 0.6 0.8 -0.7 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.2 1.5 -0.3 -1.2
Relative age voice broke 0.2 0.4 0.7 -0.4 0.8 -0.5
Taking other prescription medications 0.7 1.1 2.7 -0.7 -0.3 -1.6
Age when periods started (menarche) 1.4 3.4 6.9 1.1 1.4 -2.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.4 -1.2 -0.1 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 4.2 -2.1 0.5 -1.0
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.3 -0.0 0.4 -0.6
Qualifications: CSEs or equivalent 0.9 1.3 2.3 -1.5 0.1 -1.2
Serious illness, injury or assault to yourself 1.3 1.6 2.2 -1.1 -1.3 -1.5
High blood pressure 2.1 6.0 7.0 -2.4 2.2 2.6
Hayfever, allergic rhinitis or eczema 0.9 1.8 3.3 -1.5 -0.2 -1.8
Multivitamins +/- minerals 2.6 3.3 7.3 -2.7 1.4 0.9
Stomach or abdominal pain in last month 0.7 0.9 1.5 -0.1 -1.2 -1.0
Supplements: Glucosamine 3.6 4.7 8.0 -1.3 2.1 2.8
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 4.0 -2.0 -0.6 0.4
Medication: Atenolol 2.3 2.9 4.4 -0.6 2.0 2.1
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.7 -0.2 -0.3
Sitting height 0.0 0.3 0.6 -0.2 -0.8 -0.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.2 -0.5 0.2
High blood pressure (mother) 1.8 2.5 3.6 -1.8 0.6 1.9
Body mass index (BMI) 7.3 30.9 45.3 -6.7 4.6 5.1
Impedance of leg (left) 3.8 18.6 24.5 5.0 -3.5 -4.4
Leg predicted mass (left) 4.6 24.5 41.0 -6.4 3.8 4.2
Trunk fat mass 5.4 23.0 39.2 -6.3 3.7 4.0
Waist circumference 6.2 22.9 33.7 -5.8 4.0 4.4
Number of incorrect matches in round 4.6 7.6 15.9 -2.3 4.0 1.3
Past tobacco smoking 0.5 0.9 1.7 0.3 -1.3 -0.9
Alcohol usually taken with meals 0.2 0.4 0.6 -0.8 0.5 0.5
Nervous feelings 0.6 1.1 2.4 -0.0 -0.9 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.5 0.6 -1.1 -1.6
Hearing difficulty/problems with background noise 3.1 4.9 7.1 2.2 -2.7 -1.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.3 0.2 -0.2
Had menopause 1.1 1.4 3.0 -0.5 0.9 1.7
Had other major operations 1.8 2.2 4.3 -0.2 -1.6 -2.1
Forced vital capacity (FVC) 0.2 0.7 1.3 -1.0 -0.0 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.8 -1.4 0.0 -1.0
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.1 0.1 -0.1 -0.3
Qualifications: None of the above 0.5 1.0 2.1 -0.5 0.8 1.4
Financial difficulties in last 2 years 0.2 0.3 0.4 -0.6 0.6 -0.5
Mouth/teeth dental problems 0.3 0.4 0.6 -0.1 0.8 -0.7
Heart attack 1.1 1.4 3.0 0.6 1.0 1.7
Allergy 1.0 2.3 4.3 1.3 1.0 2.1
Pain all over the body in last month 0.8 0.8 1.6 0.1 -1.0 -1.3
Diabetes (self-reported) 0.6 0.9 1.8 -0.6 0.7 1.3
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.1 0.2 -1.4 -1.8
Medication: Ramipril 0.2 0.2 0.6 0.4 -0.1 0.8
Medication: Simvastatin 1.5 2.2 4.3 -1.4 2.1 0.6
Fluid intelligence score 0.1 0.3 0.5 0.3 -0.7 0.4
Illnesses of siblings 2.0 2.8 7.9 -0.8 0.1 -2.8
Neuroticism score 1.4 2.9 4.2 1.0 -2.1 -1.9
Weight 5.9 29.0 48.0 -6.9 4.2 4.6
Impedance of arm (right) 2.3 10.8 12.9 3.5 -2.7 -3.6
Arm fat percentage (right) 5.6 22.0 37.3 -6.1 3.8 3.8
Trunk fat-free mass 2.6 14.8 21.6 -4.7 3.4 3.4
Hip circumference 6.0 26.0 43.4 -6.6 4.4 3.9
Time employed in main current job 1.6 1.8 3.8 0.8 1.0 2.0
Alcohol intake versus 10 years previously 0.6 0.9 1.5 -0.9 0.8 1.2
Father’s age at death 0.8 1.1 2.6 -1.6 0.2 -0.9
Worrier / anxious feelings 1.1 2.2 3.8 -0.2 -1.6 -1.9
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 0.6 -0.9 -0.8
Falls in the last year 0.5 0.7 1.8 0.1 -1.3 -0.5
Hair/balding pattern: Pattern 3 0.2 0.4 0.7 0.8 -0.6 0.0
Number of live births 0.6 0.9 1.0 0.9 -0.9 -1.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.4 -0.7 -0.3 -0.5
Pulse rate 0.2 0.3 0.5 -0.6 -0.3 0.7
Happiness 0.3 0.4 0.6 0.7 0.8 0.1
Noisy workplace 1.5 1.9 3.3 1.8 -1.5 0.2
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 -0.4 -0.7 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.1 -0.8 0.2 -1.1
Mouth/teeth dental problems: Dentures 1.8 3.1 8.6 -0.4 0.8 2.9
Asthma 0.6 1.2 3.1 -0.7 -0.4 -1.8
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 3.6 0.6 -1.9 -1.5
Medication: Cholesterol lowering 1.4 2.2 2.9 -1.2 1.4 1.7
Depression (self-reported) 1.2 1.4 2.1 0.7 -1.3 -1.4
Medication: Lansoprazole 0.1 0.1 0.2 -0.3 -0.4 -0.2
Prospective memory result 0.6 0.8 1.1 -0.8 0.7 1.0
Lung cancer (father) 1.2 1.5 1.7 1.1 -1.2 -1.3
Illnesses of mother 0.3 0.4 0.9 0.4 0.9 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.1 -1.1 -0.3 -0.6
Pulse wave Arterial Stiffness index 1.0 1.2 2.2 0.2 -1.5 -1.1
Impedance of arm (left) 3.2 15.0 18.3 4.0 -3.3 -4.3
Arm fat mass (right) 6.6 27.2 43.4 -6.6 4.2 4.5
Trunk predicted mass 2.6 15.0 22.0 -4.7 3.4 3.4
Standing height 0.1 0.6 1.4 -1.2 -0.3 -0.7
Length of working week for main job 0.6 0.6 0.8 0.9 0.8 0.6
Exposure to tobacco smoke at home 0.9 1.0 1.5 1.0 0.7 1.2
Breastfed as a baby 1.2 1.5 2.2 -0.1 1.5 1.5
Tense / ‘highly strung’ 0.6 1.0 1.1 1.0 -1.0 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 5.0 2.0 -1.4 -2.2
Hair/balding pattern: Pattern 4 0.9 2.1 4.0 -2.0 0.6 1.4
Birth weight of first child 0.6 1.1 2.8 -1.7 0.2 -0.7
Peak expiratory flow (PEF) 0.2 0.5 1.3 -1.1 -0.3 0.6
Pulse wave reflection index 0.7 0.9 1.2 0.7 -1.1 -1.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.3 1.5 -0.2 -0.3
Loud music exposure frequency 1.6 1.8 4.5 0.9 -2.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.9 -0.0 -0.7 -1.0
Mouth/teeth dental problems: Bleeding gums 4.3 5.5 8.0 2.6 -2.8 -1.3
Blood clot in the leg (DVT) 1.3 1.7 3.9 -2.0 -0.1 -1.1
Medication: Paracetamol 0.6 0.9 1.5 -0.8 -0.8 -1.2
Headache pain in last month 0.1 0.1 0.2 -0.2 -0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 0.9 1.6 2.9 1.7 -1.0 -0.9
Glaucoma (self-reported) 1.9 2.2 6.3 0.1 -2.5 -0.6
Gout (self-reported) 0.4 0.6 1.1 -1.0 0.6 0.5
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 1.6 1.3 -1.1 -0.9
Medication: Amlodipine 0.2 0.3 0.8 -0.9 -0.1 -0.1
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.8 -0.4 1.3 1.7
Birth weight 0.6 1.3 2.7 1.6 -1.0 0.5
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.4 0.4 0.7 -0.5
High blood pressure (siblings) 2.2 3.1 7.5 -0.4 1.3 2.7
Forced vital capacity (FVC), Best measure 0.4 1.5 2.4 -1.4 -0.4 -1.5
Body fat percentage 4.7 18.7 33.2 -5.8 3.3 3.4
Leg fat percentage (right) 5.5 20.1 31.8 -5.6 3.7 3.8
Arm fat-free mass (right) 3.1 15.8 25.4 -5.0 3.1 3.5
Exposure to tobacco smoke outside home 2.0 2.6 6.5 2.5 -0.9 0.7
Comparative body size at age 10 6.5 18.0 30.1 -5.5 3.2 3.7
Number of full brothers 0.8 1.0 2.2 -0.1 -1.5 -0.9
Worry too long after embarrassment 0.6 1.1 1.6 0.4 -1.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 4.5 1.3 -1.6 -2.1
Wheeze or whistling in the chest in last year 0.3 0.5 1.3 0.1 0.4 1.2
Number of children fathered 2.6 2.9 3.5 1.6 -1.6 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 3.2 3.7 4.8 -2.2 2.1 1.3
Age at first live birth 0.3 0.6 1.3 0.2 0.6 1.2
Pulse wave peak to peak time 1.1 1.3 2.4 -0.5 1.5 1.1
Health satisfaction 0.4 0.5 1.2 0.4 -1.1 -0.4
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.5 -0.1 0.2
Qualifications: College or University degree 0.2 0.7 1.4 0.7 1.2 0.6
Eye problems/disorders: None of the above 0.8 0.9 1.2 0.6 1.1 1.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.6 0.9 -1.6 -0.9
Emphysema/chronic bronchitis 1.0 1.1 1.6 1.3 -0.8 1.0
Medication for pain relief, constipation, heartburn 0.2 0.4 0.5 0.7 0.6 0.4
Neck or shoulder pain in last month 0.1 0.2 0.4 -0.6 0.3 0.4
Medication: Blood pressure 2.2 3.9 7.5 -2.7 1.7 1.1
Angina (self-reported) 1.3 1.6 4.0 0.3 0.9 2.0
Migraine (self-reported) 0.1 0.1 0.2 -0.5 0.0 -0.2
Medication: Ibuprofen 2.9 3.5 5.5 0.9 -2.4 -2.0
Medication: Allopurinol 0.3 0.4 0.7 -0.4 0.7 0.8
Medication: Omeprazole 1.9 2.3 3.6 -1.2 1.3 1.9
Medication: Seretide 50 evohaler 1.6 1.9 4.7 -0.5 0.8 2.2
Mean time to correctly identify matches 0.8 1.5 2.3 -0.5 1.4 1.5
Heart disease (mother) 2.0 2.5 7.2 -2.7 0.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 5.9 -0.2 1.0 2.4
Whole body fat mass 6.3 26.2 42.3 -6.5 4.0 4.5
Leg fat mass (right) 7.4 28.6 47.3 -6.9 4.1 4.6
Arm predicted mass (right) 3.2 16.4 25.2 -5.0 3.3 3.6
Pulse rate, automated reading 0.2 0.5 1.4 -0.4 0.2 1.2
Alcohol intake frequency. 0.4 0.9 2.4 -0.5 -0.2 1.5
Comparative height size at age 10 0.2 0.9 2.0 -1.4 -0.6 0.5
Number of full sisters 0.2 0.3 0.7 -0.8 0.3 -0.4
Suffer from ‘nerves’ 2.1 3.2 6.2 1.2 -1.4 -2.5
Overall health rating 0.2 0.4 0.6 -0.8 0.2 -0.7
Chest pain or discomfort 0.5 0.7 1.5 0.3 0.6 1.2
Had major operations 2.4 2.8 3.2 -1.8 1.8 1.4
Age at last live birth 0.8 1.1 2.4 -0.4 1.5 0.9
Family relationship satisfaction 0.5 0.7 1.9 1.4 -0.2 0.2
Leg pain on walking 0.6 0.7 1.3 -0.1 0.9 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.2 1.1 -0.9 -0.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.6 -0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 5.2 2.3 -0.3 1.1
Medication: Aspirin 3.0 4.0 5.8 -1.8 1.7 2.4
Supplements: Vitamin C 0.6 0.7 1.8 -1.4 0.4 0.3
Knee pain experienced in last month 0.4 0.6 0.9 -0.6 0.8 -1.0
Hypertension (Self-reported) 2.2 6.2 7.3 -2.4 2.3 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.1 4.8 7.8 -2.8 1.9 1.7
Illnesses of father: Heart disease 0.1 0.1 0.3 -0.5 -0.4 -0.0
Illnesses of siblings: Diabetes 0.6 0.8 2.1 0.4 0.2 1.5
Smoking status: Previous 0.9 1.3 2.6 -0.9 1.6 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.0 -0.3 -1.0 -0.9
Whole body fat-free mass 3.6 20.3 32.6 -5.7 3.8 3.8
Leg fat-free mass (right) 3.8 20.5 35.3 -5.9 3.3 3.9
Arm fat percentage (left) 5.1 20.3 34.8 -5.9 3.6 3.6
Average weekly red wine intake 2.1 3.0 7.5 -2.7 1.3 -0.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.0 1.0 -0.8 0.2
Mood swings 1.0 1.9 3.1 1.0 -1.8 -1.2
Loneliness, isolation 1.2 1.6 3.8 0.5 -0.9 -2.0
Long-standing illness, disability or infirmity 0.5 0.8 1.7 -0.6 -0.5 -1.3
Ever had bowel cancer screening 0.3 0.3 0.4 0.7 0.3 -0.6
Diabetes diagnosed by doctor 0.2 0.4 0.8 -0.9 0.0 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 0.7 -0.3 -0.3
Friendships satisfaction 0.8 0.9 1.5 1.1 -1.2 -0.2
Qualifications: nursing, teaching 1.7 2.7 6.0 -1.1 2.4 0.9
Commuting to job workplace: Walk 1.7 1.9 3.6 -1.9 0.8 -1.2
Eye problems/disorders: Cataract 0.5 0.6 1.2 0.6 -0.5 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 0.4 -0.5 -0.2
Medication for cholesterol 0.9 1.4 2.0 0.7 -1.4 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.9 -2.2 0.7 0.2
Back pain experienced in last month 0.0 0.1 0.1 0.4 0.2 -0.1
Mineral and other dietary supplements 1.7 2.2 3.8 1.9 -0.8 -1.5
Breast cancer (self-reported) 0.8 0.9 2.5 -1.6 0.5 -0.2
Asthma (self-reported) 0.6 1.2 2.5 -1.0 -0.3 -1.6
Osteoporosis (self-reported) 2.5 3.1 5.1 1.4 -2.3 -1.5
Osteoarthritis (self-reported) 0.3 0.4 1.0 0.5 -1.0 0.1
Medication: Aspirin 1.3 1.7 2.8 -1.4 0.7 1.7
Medication: Gliclazide 2.7 3.0 4.6 -2.0 2.1 0.6
Illnesses of father: None of the above (group 1) 0.3 0.3 0.8 0.9 -0.2 0.4
Smoking status: Current 0.1 0.2 0.3 0.3 -0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.7 -0.1 -0.0 -0.8
Whole body water mass 3.6 20.4 33.5 -5.8 3.7 3.7
Leg predicted mass (right) 3.9 20.8 35.9 -6.0 3.4 3.9
Arm fat mass (left) 6.5 26.6 42.1 -6.5 4.2 4.5
Number of self-reported non-cancer illnesses 0.5 0.9 1.8 -1.4 -0.9 -0.1
Average weekly champagne plus white wine intake 1.2 1.6 3.6 -1.9 1.1 0.3
Miserableness 0.3 0.5 1.0 1.0 -0.6 -0.5
Guilty feelings 0.3 0.5 1.1 -0.4 -0.5 -1.1
Wears glasses or contact lenses 0.0 0.0 0.1 -0.1 0.1 0.3
Ever taken oral contraceptive pill 0.2 0.2 0.5 0.7 -0.1 -0.0
Hearing aid user 1.3 1.5 3.2 0.1 -1.1 -1.8
Mother’s age at death 1.0 1.3 2.6 1.1 0.3 1.6
Financial situation satisfaction 1.3 1.6 2.1 1.4 -1.4 -1.0
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.2 -0.5 -0.3 0.4
Commuting to job workplace: Public transport 1.4 1.7 2.5 -1.6 1.5 0.4
Eye problems/disorders: Glaucoma 0.7 0.8 2.1 -0.5 -1.4 -0.3
Medication: Blood pressure 0.1 0.2 0.3 -0.3 0.5 0.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 -0.3 0.4 0.7
Supplements: Fish oil (including cod liver oil) 3.3 4.4 5.5 -2.2 1.7 2.3
High cholesterol (Self-reported) 2.4 4.2 5.5 -2.3 2.4 1.4
Medication: Bendroflumethiazide 0.6 0.9 1.5 -0.7 0.9 1.2
Medication: Paracetamol 1.1 1.7 2.5 -0.9 -1.3 -1.6
Medication: Lisinopril 2.9 3.8 4.5 -2.1 2.0 1.7
Medication: Atorvastatin 1.4 1.7 4.3 0.4 0.8 2.1
Illnesses of father: High blood pressure 0.2 0.2 0.7 0.1 0.8 -0.3
Alcohol drinker status: Never 0.7 0.8 1.2 1.1 -0.3 1.1
Ever smoked 0.1 0.2 0.5 -0.1 0.7 0.5
Basal metabolic rate 4.1 22.8 37.3 -6.1 3.9 4.0
Leg fat percentage (left) 5.0 17.9 31.0 -5.6 3.4 3.4
Arm fat-free mass (left) 4.4 22.2 35.2 -5.9 4.0 3.9
Number of operations (self-reported) 0.2 0.2 0.4 -0.6 0.2 0.5
Average weekly beer plus cider intake 0.3 0.4 0.7 0.8 0.3 0.6
Irritability 4.3 7.2 12.5 3.5 -2.4 -1.9
Risk taking 0.5 0.7 1.6 0.4 1.3 0.7
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.4 -0.7 0.2 0.1
Fractured/broken bones in last 5 years 1.1 1.5 2.3 0.8 -1.5 -1.2
Age started oral contraceptive pill 0.3 0.4 1.1 -0.2 0.3 -1.0
Diastolic blood pressure, automated reading 0.5 1.6 3.7 -0.7 0.8 1.9
Ever depressed for a whole week 0.4 0.5 0.9 0.7 -0.9 -0.5
Unable to work because of sickness or disability 1.5 2.0 2.8 1.3 -1.2 -1.7
Commuting to job workplace: Cycle 1.4 1.6 4.5 0.2 -0.6 -2.1
Myopia 0.6 0.9 1.1 0.9 -1.1 -0.9
Vascular/heart problems diagnosed by doctor 1.7 4.5 6.7 1.8 -1.9 -2.6
Cholesterol lowering medication 0.3 0.5 0.7 -0.7 0.8 0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.1 -0.1 0.3 1.1
Pain experienced in last month 0.1 0.1 0.2 0.4 0.2 0.3
Supplements: Calcium 0.3 0.4 0.7 -0.5 -0.2 -0.9
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 -0.5 -0.1 -0.6
Heart attack/myocardial infarction (self-reported) 0.9 1.1 2.1 0.6 0.9 1.4
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 3.3 -1.8 -0.3 -1.1
Heart disease (siblings) 1.3 1.6 2.2 1.5 -0.7 1.5
Alcohol drinker status: Previous 0.2 0.2 0.2 0.5 -0.5 0.5
Pack years of smoking 1.8 2.7 5.1 1.5 -2.3 -0.9
Impedance of whole body 4.0 20.2 24.1 4.9 -3.9 -4.6
Leg fat mass (left) 6.9 27.1 46.6 -6.8 4.0 4.3
Arm predicted mass (left) 4.0 20.4 32.4 -5.7 3.9 3.7