Hub : Genes

BAIAP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.362 0.107 4.7e-03 0.012 NA 0.023 NA -0.002 1.6e-01 NA 8.5e-02 NA 3.6e-01
2 GTEx Thyroid 0.196 0.052 9.3e-05 0.028 NA 0.048 NA 0.087 3.1e-03 NA 1.4e-04 NA 3.7e-07
3 TCGA Bladder Urothelial Carcinoma 0.093 0.035 2.9e-04 0.043 0.062 0.054 NA 0.040 1.6e-04 5.5e-06 2.3e-05 NA 2.6e-04
4 TCGA Thyroid Carcinoma 0.173 0.043 4.3e-12 0.059 0.133 0.097 NA 0.137 2.0e-06 7.5e-13 1.2e-09 NA 2.9e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.8 -0.5 0.9 -0.1 -0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 1.8 0.0 -0.6 -1.3 -0.8
Depressed Affect (Nagel 2018) 4.0 8.5 19.4 2.0 2.9 1.3 4.4
Depression (Nagel 2018) 4.3 6.4 14.0 2.4 2.2 1.1 3.7
Intelligence (Savage-Jansen 2018) 1.3 4.1 7.9 0.9 2.8 0.5 2.8
Neuroticism (Nagel 2018) 5.5 13.0 29.5 1.3 3.7 2.7 5.4
Schizophrenia (2018) 0.3 0.6 1.1 0.4 -0.9 -1.1 -0.6
Schizophrenia vs Biploar Disorder 0.2 0.2 0.6 -0.4 -0.8 0.0 0.0
Worry (Nagel 2018) 3.5 7.3 18.0 1.1 2.3 2.2 4.2
Alzheimer’s Disease (in mother) 0.7 0.8 1.3 -0.6 -1.1 -0.9 -0.8
Alzheimer’s Disease (in father) 0.5 0.5 0.9 0.8 0.8 0.0 -0.9
Alzheimer’s Disease (including proxy) 0.7 1.1 2.8 -0.1 -1.1 -0.5 -1.7
Crohns Disease (2017) 1.1 2.3 4.0 0.6 -2.0 -1.6 -1.6
Irritable Bowel Disease (IBD) 1.1 2.7 7.3 0.8 -2.7 -1.2 -1.2
Ulcerative Colitis (UC) 1.0 1.8 5.7 -0.1 -2.4 -0.9 -0.9
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.2 0.4 0.8 -0.6 -0.5 -0.9 0.3
Verbal and Numeric Reasoning (VNR) 0.6 1.5 3.7 -0.3 1.9 -0.1 1.4
Breast Cancer 1.6 4.0 10.0 -0.5 1.3 3.2 2.0
Ovarian Cancer 0.8 1.1 2.6 1.2 0.4 1.6 0.4
Prostate Cancer 0.3 0.5 0.8 -0.5 0.8 0.9 0.3
Age at First Birth 0.4 0.6 1.0 -0.1 -1.0 0.8 -0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 4.9 6.7 12.1 -3.5 -1.6 -2.6 -2.3
Coronary Artery Disease (CAD) 0.4 0.5 1.2 -1.1 0.8 0.0 0.0
Crohns Disease (2012) 0.1 0.1 0.5 0.7 0.0 0.0 0.0
Mean Putamen Volume 2.5 2.9 4.5 -0.2 -1.8 -2.1 -1.9
Fasting Glucose 1.2 1.5 3.6 -0.9 -1.9 -0.7 -1.0
HbA1C 0.3 0.3 1.0 0.1 -0.4 -1.0 -0.4
HDL Cholesterol 0.0 0.0 0.0 0.1 0.2 -0.2 0.0
LDL Cholesterol 1.3 2.1 2.8 -1.0 -1.7 -1.5 -1.6
Lupus 1.1 1.7 3.1 1.8 -0.9 -1.4 -0.9
Neuroticism (2016) 3.7 5.3 7.6 1.4 2.8 2.4 2.5
Primary Biliary Cirrhosis 0.2 0.3 0.7 -0.1 -0.6 -0.8 -0.2
Rheumatoid Arthritis 0.6 0.8 2.6 -1.6 0.5 -0.5 0.1
Schizophrenia (2014) 0.3 0.6 0.9 -0.5 -0.7 -1.0 -0.9
Triglycerides 0.3 0.5 1.0 -1.0 -0.3 -0.4 -0.9
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.1 -0.4 -1.1 0.0 0.0
Ulcerative Colitis 0.1 0.1 0.2 0.3 -0.5 0.3 0.3
Blood Eosinophil Count 0.6 4.5 7.1 -1.9 2.7 1.7 2.2
Blood Platelet Count 0.5 6.2 9.7 1.1 3.1 2.6 2.7
Blood Red Count 0.1 0.7 1.1 -0.5 -0.8 -0.9 -1.1
Blood White Count 0.7 5.0 9.7 -1.3 3.1 1.4 2.5
Heel T-Score 0.5 3.9 6.7 -1.3 1.7 2.6 2.1
BMI 4.1 23.7 82.4 -9.1 0.5 -2.8 -2.1
Height 1.8 35.0 75.9 2.6 -5.3 -5.4 -8.7
Waist Hip Ratio (WHR) 1.3 5.7 10.2 0.5 3.2 2.4 2.5
Systolic Blood Pressure 0.3 1.7 5.6 -0.6 -2.4 0.5 -0.8
Smoking Status 0.9 2.2 4.9 -2.2 1.1 -0.6 1.5
Allergy or Eczema 0.3 0.7 2.0 1.4 -0.1 -0.5 -0.8
Cardiovascular Disease 0.2 0.8 1.3 -1.1 -0.8 -0.6 -0.9
Hypothyroidism (self reported) 0.3 0.7 2.7 1.6 -0.5 -0.0 -0.1
Respiratory disease 0.8 1.8 3.3 0.8 1.7 1.8 0.6
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.4 -1.2 0.2 -1.1 -1.1
Lung FEV1/FVC ratio 0.2 1.1 2.9 -0.0 -1.7 -0.2 -1.1
Lung FVC 0.2 1.0 3.4 -0.3 1.8 0.2 0.5
Neuroticism 3.8 9.2 22.8 1.6 2.9 1.7 4.8
Chronotype (morning person) 1.3 2.9 5.0 1.2 0.5 2.2 2.2
Hair Pigment 0.2 4.4 15.1 3.9 -0.6 0.3 -1.4
Tanning 0.3 3.8 9.1 -1.5 1.3 1.5 3.0
Hand grip strength (left) 0.7 1.9 3.8 -1.9 -0.3 -1.2 -1.6
Number of treatments/medications taken 0.6 1.1 2.0 0.4 -1.3 -0.7 -1.4
Average weekly spirits intake 0.4 0.5 1.2 -1.1 0.5 0.5 0.5
Sensitivity / hurt feelings 1.9 3.2 5.5 -0.9 1.1 2.3 2.3
Frequency of depressed mood in last 2 weeks 2.5 3.5 8.1 1.9 1.5 -0.1 2.8
Hearing difficulty/problems: Yes 0.4 0.6 1.5 1.2 -0.5 -0.9 -0.1
Relative age of first facial hair 0.2 0.4 0.9 0.9 0.6 -0.4 -0.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.3 -0.9 0.4 -1.0 -1.1
Ever used hormone-replacement therapy (HRT) 2.1 2.6 5.8 -1.1 1.2 1.4 2.4
Ever had hysterectomy (womb removed) 1.5 1.7 4.3 0.3 1.4 2.1 0.8
Systolic blood pressure, automated reading 0.7 2.0 7.0 -2.6 -0.8 0.4 0.2
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.0 -0.9 0.4 0.9 1.0
Angina 0.2 0.2 0.8 -0.1 -0.2 -0.2 -0.9
Medication for hormone replacement therapy 1.3 1.4 4.3 -2.1 0.5 0.8 0.7
Vitamin and mineral supplements 0.8 1.1 1.5 0.9 1.2 0.8 1.2
Supplements: Zinc 1.0 1.0 2.5 0.5 -1.1 -0.4 -1.6
Medication: Co-codamol 0.2 0.2 0.9 -0.0 0.9 -0.0 0.0
Medication: Metformin 1.7 2.4 4.9 -0.3 -1.3 -1.7 -2.2
Diabetes (father) 0.7 0.9 3.6 -1.9 -0.1 0.2 0.1
Diabetes (mother) 0.0 0.0 0.1 0.1 0.1 -0.1 0.3
Severe depression (siblings) 0.3 0.3 0.6 0.8 -0.4 -0.5 0.6
Pack years adult smoking proportion 2.0 3.0 8.2 -0.8 -1.3 -2.9 -1.1
Impedance of leg (right) 2.0 9.6 16.9 4.1 2.1 2.7 3.1
Leg fat-free mass (left) 4.0 21.4 28.7 -5.0 -3.1 -4.7 -5.4
Trunk fat percentage 1.4 5.7 14.8 -3.8 -1.3 -1.7 -1.8
Hand grip strength (right) 1.1 3.0 6.7 -2.6 -0.8 -1.2 -1.8
Townsend deprivation index at recruitment 1.3 1.8 4.4 -0.5 -0.3 -2.1 -1.5
Current tobacco smoking 1.7 2.9 6.0 -1.3 2.4 0.0 1.9
Average weekly fortified wine intake 2.2 2.6 5.9 -0.9 -1.2 -1.5 -2.4
Maternal smoking around birth 0.5 0.7 1.3 -1.0 -0.4 -0.6 -1.1
Fed-up feelings 0.7 1.3 3.6 0.2 1.1 -0.2 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 6.5 1.4 1.5 1.2 2.5
Relative age voice broke 0.5 0.7 2.4 -1.5 -0.0 -0.7 -0.0
Taking other prescription medications 0.1 0.1 0.3 -0.3 0.4 0.3 -0.5
Age when periods started (menarche) 0.3 0.6 1.5 0.6 -1.2 -0.8 0.1
Bilateral oophorectomy (both ovaries removed) 1.8 2.0 3.0 -1.0 1.7 1.6 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.9 -0.7 -0.9 0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.9 -2.0 0.2 -1.3 -0.4
Qualifications: CSEs or equivalent 0.1 0.1 0.3 -0.4 -0.2 0.5 0.1
Serious illness, injury or assault to yourself 0.5 0.6 1.4 0.9 1.2 0.2 -0.3
High blood pressure 0.2 0.7 1.2 -1.1 -0.8 0.4 -0.9
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.0 1.7 0.7 0.0 -0.2
Multivitamins +/- minerals 1.2 1.5 2.0 -1.2 -1.2 -1.1 -1.4
Stomach or abdominal pain in last month 0.5 0.6 1.0 -0.5 -0.9 -0.5 1.0
Supplements: Glucosamine 0.2 0.3 0.6 -0.8 0.0 0.7 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.7 -0.1 0.3 -0.4
Medication: Atenolol 1.5 1.9 5.0 -0.7 -2.2 -0.8 -1.2
Medication: Levothyroxine sodium 0.6 1.0 3.1 1.8 0.2 0.9 0.5
Sitting height 2.1 14.9 28.0 -0.1 -4.0 -4.0 -5.3
Chronic bronchitis/emphysema (father) 2.7 3.1 6.8 0.1 2.6 1.7 1.7
High blood pressure (mother) 1.0 1.4 3.4 -1.9 0.8 0.7 1.0
Body mass index (BMI) 3.9 16.7 53.9 -7.3 -1.0 -2.7 -2.2
Impedance of leg (left) 2.0 9.9 22.5 4.7 1.6 2.6 2.9
Leg predicted mass (left) 4.0 21.1 28.5 -5.0 -3.1 -4.6 -5.3
Trunk fat mass 2.6 11.4 24.9 -5.0 -1.9 -2.7 -3.1
Waist circumference 2.6 9.5 30.8 -5.5 -0.1 -1.9 -1.9
Number of incorrect matches in round 0.3 0.5 1.5 -0.2 -0.5 1.2 0.0
Past tobacco smoking 0.5 0.9 2.8 1.7 0.3 0.4 -0.7
Alcohol usually taken with meals 5.4 8.8 11.8 3.4 2.6 3.4 2.2
Nervous feelings 1.0 1.9 5.4 0.1 1.4 0.6 2.3
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.0 7.8 -0.7 2.0 -0.2 2.8
Hearing difficulty/problems with background noise 0.7 1.2 2.7 1.6 1.1 -0.7 0.5
Hair/balding pattern: Pattern 2 0.8 1.1 2.1 1.4 1.4 -0.0 0.4
Had menopause 0.9 1.1 2.3 -1.5 0.2 1.0 1.0
Had other major operations 0.5 0.7 1.2 0.8 -0.2 -0.9 -1.1
Forced vital capacity (FVC) 0.3 1.0 3.1 0.7 1.8 -0.4 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 -0.3 -0.6 0.6 -0.0
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.4 -1.8 0.6 -0.2 1.4
Qualifications: None of the above 0.8 1.7 6.6 -2.6 -0.2 0.4 -0.0
Financial difficulties in last 2 years 0.1 0.2 0.5 -0.3 0.3 -0.7 -0.0
Mouth/teeth dental problems 1.7 2.6 6.0 1.5 -2.4 -0.7 -1.3
Heart attack 0.1 0.1 0.4 -0.0 -0.2 -0.6 0.1
Allergy 0.3 0.7 1.7 -1.3 -0.8 0.3 0.5
Pain all over the body in last month 1.0 1.1 1.9 1.0 -1.4 -1.1 -0.4
Diabetes (self-reported) 0.8 1.2 2.9 -0.6 -0.7 -1.1 -1.7
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 6.0 2.4 -0.1 0.1 -0.6
Medication: Ramipril 0.3 0.4 0.9 -0.6 -0.9 -0.7 -0.2
Medication: Simvastatin 0.2 0.3 0.9 -0.9 -0.5 -0.1 0.4
Fluid intelligence score 1.4 2.9 7.8 -0.0 1.8 0.7 2.8
Illnesses of siblings 0.8 1.1 3.9 2.0 -0.2 -0.8 -0.1
Neuroticism score 3.2 6.7 16.0 1.6 2.4 1.5 4.0
Weight 3.9 19.2 36.4 -6.0 -2.3 -3.9 -4.5
Impedance of arm (right) 2.2 10.5 34.3 5.9 1.0 2.2 1.4
Arm fat percentage (right) 2.4 9.4 32.0 -5.7 -0.4 -1.6 -1.7
Trunk fat-free mass 3.7 21.3 33.1 -4.9 -2.9 -4.5 -5.8
Hip circumference 2.7 11.6 22.7 -4.8 -1.8 -3.2 -3.2
Time employed in main current job 0.9 1.0 2.4 -1.6 -0.3 0.6 1.1
Alcohol intake versus 10 years previously 0.5 0.7 1.7 -0.7 -0.5 -1.3 -0.5
Father’s age at death 1.8 2.4 4.2 2.1 1.5 1.3 1.1
Worrier / anxious feelings 1.0 1.8 4.6 1.1 0.2 1.2 2.1
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 4.4 0.7 1.2 -0.4 2.1
Falls in the last year 0.5 0.7 1.6 0.3 0.1 -1.3 -1.0
Hair/balding pattern: Pattern 3 0.4 0.5 1.0 -1.0 -0.9 0.1 0.5
Number of live births 0.8 1.2 2.7 -1.6 -0.5 -1.2 0.6
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 3.6 0.5 1.9 0.0 -0.5
Pulse rate 0.7 1.2 2.6 0.4 0.7 1.2 1.6
Happiness 0.6 0.7 1.7 -0.7 0.7 0.3 1.3
Noisy workplace 0.8 1.0 3.4 0.4 -0.1 -0.7 -1.9
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.8 1.7 1.2 -0.7 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.1 1.5 0.4 -0.9 -0.2
Mouth/teeth dental problems: Dentures 3.0 5.0 18.1 -4.2 1.1 0.2 0.9
Asthma 0.3 0.6 1.0 1.0 0.7 0.7 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 4.8 2.2 0.2 0.6 -0.4
Medication: Cholesterol lowering 0.5 0.8 1.2 -1.1 -1.1 -0.6 -0.8
Depression (self-reported) 0.7 0.9 1.8 -0.4 1.2 -0.1 1.3
Medication: Lansoprazole 0.3 0.3 0.6 0.2 0.7 0.2 0.8
Prospective memory result 2.1 2.6 6.7 -0.2 -2.6 -0.9 -1.7
Lung cancer (father) 0.4 0.5 1.0 1.0 0.3 0.7 0.7
Illnesses of mother 0.4 0.5 1.1 0.5 -0.2 -1.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.7 1.1 1.6 0.0 -0.5
Pulse wave Arterial Stiffness index 1.7 2.0 4.8 2.2 0.7 1.5 0.6
Impedance of arm (left) 3.3 15.2 50.7 7.1 1.0 2.6 1.6
Arm fat mass (right) 3.5 14.6 41.2 -6.4 -1.1 -2.7 -2.9
Trunk predicted mass 3.7 21.1 32.6 -4.9 -2.9 -4.4 -5.7
Standing height 1.3 13.1 28.8 1.8 -3.1 -3.2 -5.4
Length of working week for main job 2.3 2.5 5.1 -2.3 -0.8 -1.5 -1.5
Exposure to tobacco smoke at home 1.3 1.4 2.5 -1.6 -0.7 -1.4 -0.8
Breastfed as a baby 0.7 0.9 3.2 -1.8 -0.5 -0.1 -0.3
Tense / ‘highly strung’ 7.9 13.0 23.8 1.2 3.6 3.7 4.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.9 4.5 9.0 0.9 2.7 0.8 3.0
Hair/balding pattern: Pattern 4 0.3 0.7 1.7 -1.3 0.3 1.0 0.4
Birth weight of first child 0.0 0.1 0.1 -0.3 0.1 -0.4 0.0
Peak expiratory flow (PEF) 0.5 1.2 2.7 -0.6 0.1 -1.3 -1.6
Pulse wave reflection index 0.6 0.8 2.9 1.7 -0.2 0.4 0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.6 -1.3 0.8 0.2 0.6
Loud music exposure frequency 0.8 0.9 2.6 0.4 -0.1 -0.9 -1.6
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 6.1 2.5 1.0 0.1 0.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.8 1.1 1.7 0.1 0.7
Blood clot in the leg (DVT) 0.2 0.2 0.3 0.5 0.5 -0.1 0.5
Medication: Paracetamol 2.6 4.4 8.8 0.8 -1.6 -3.0 -2.3
Headache pain in last month 0.6 1.1 3.2 1.8 0.0 -0.5 1.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.9 0.4 0.9 0.0 0.1
Glaucoma (self-reported) 0.4 0.4 1.0 0.8 -1.0 -0.2 0.3
Gout (self-reported) 0.8 1.1 3.2 -0.7 0.5 0.7 -1.8
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.8 2.2 -0.2 0.6 0.3
Medication: Amlodipine 0.2 0.3 0.6 -0.1 -0.2 0.6 0.8
Medication: Ventolin 100micrograms inhaler 1.7 2.1 4.6 -2.1 -0.5 -0.7 -1.8
Birth weight 2.5 5.5 8.4 -1.2 -2.2 -2.9 -2.7
Chronic bronchitis/emphysema (mother) 1.6 1.8 4.0 -1.1 0.3 1.4 2.0
High blood pressure (siblings) 1.8 2.6 5.7 -1.4 1.1 2.4 1.4
Forced vital capacity (FVC), Best measure 0.4 1.3 2.4 1.5 1.5 -0.3 -0.7
Body fat percentage 1.8 7.2 22.9 -4.8 -0.9 -1.7 -1.5
Leg fat percentage (right) 3.0 10.9 38.2 -6.2 -0.3 -2.1 -1.1
Arm fat-free mass (right) 3.6 18.3 25.8 -5.1 -2.7 -4.2 -4.7
Exposure to tobacco smoke outside home 0.4 0.6 1.4 0.2 1.2 -0.6 -0.7
Comparative body size at age 10 1.7 4.6 10.3 -3.2 0.4 -1.7 -2.2
Number of full brothers 1.1 1.4 3.7 0.5 -0.7 -1.9 -1.0
Worry too long after embarrassment 1.6 2.8 4.5 0.8 2.0 1.3 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 7.6 0.8 2.8 0.2 2.4
Wheeze or whistling in the chest in last year 1.1 2.0 7.6 -2.8 0.3 0.6 -0.2
Number of children fathered 1.1 1.3 2.0 1.1 1.0 1.4 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.3 -0.9 -1.1 -0.8 -0.4
Age at first live birth 0.7 1.2 2.9 1.7 0.5 0.9 1.0
Pulse wave peak to peak time 1.6 1.9 4.0 -2.0 -0.8 -1.6 -0.8
Health satisfaction 0.2 0.2 0.3 -0.5 0.3 -0.6 0.3
Shortness of breath walking on level ground 0.5 0.6 2.0 0.4 -0.3 -0.5 -1.4
Qualifications: College or University degree 0.0 0.1 0.1 -0.4 -0.0 -0.4 -0.1
Eye problems/disorders: None of the above 0.9 1.0 2.7 -1.6 -0.7 -0.8 -0.6
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 0.8 0.7 -0.5 0.3
Emphysema/chronic bronchitis 1.7 1.9 3.0 -1.7 -0.9 -1.3 -1.5
Medication for pain relief, constipation, heartburn 1.0 1.7 2.8 -0.8 1.5 1.1 1.7
Neck or shoulder pain in last month 0.5 0.7 2.1 -0.1 1.5 -0.1 0.7
Medication: Blood pressure 0.3 0.5 1.1 -0.9 -1.1 0.3 -0.4
Angina (self-reported) 0.1 0.2 0.6 0.0 -0.3 -0.1 -0.8
Migraine (self-reported) 0.8 1.1 2.6 1.6 0.5 -0.5 1.1
Medication: Ibuprofen 0.4 0.5 1.7 1.3 -0.2 0.3 -0.3
Medication: Allopurinol 0.6 0.8 2.4 -0.5 0.8 0.1 -1.6
Medication: Omeprazole 0.5 0.6 2.2 -1.5 0.4 -0.3 0.1
Medication: Seretide 50 evohaler 2.4 2.7 4.9 -2.2 -0.6 -1.7 -1.6
Mean time to correctly identify matches 0.4 0.7 1.8 -0.5 -0.8 -1.3 -0.1
Heart disease (mother) 0.9 1.1 3.8 0.3 0.5 2.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.3 -0.7 -1.6 -1.8 -1.1
Whole body fat mass 3.1 13.1 33.3 -5.8 -1.7 -2.7 -3.0
Leg fat mass (right) 4.1 15.9 45.3 -6.7 -1.4 -3.1 -2.6
Arm predicted mass (right) 3.7 18.7 24.5 -5.0 -2.8 -4.4 -4.8
Pulse rate, automated reading 0.3 0.9 1.7 -1.3 0.9 0.4 1.1
Alcohol intake frequency. 1.0 2.3 5.1 -0.1 -1.8 -1.0 -2.2
Comparative height size at age 10 0.8 4.3 11.0 -0.5 -1.1 -2.2 -3.3
Number of full sisters 0.2 0.3 0.6 -0.8 -0.4 -0.3 -0.4
Suffer from ‘nerves’ 3.9 6.2 11.6 2.0 2.8 1.2 3.4
Overall health rating 1.0 2.2 4.6 -2.1 -0.0 -2.0 -0.4
Chest pain or discomfort 0.9 1.3 3.0 -1.7 1.3 0.3 0.5
Had major operations 1.0 1.2 2.8 -0.7 1.7 1.0 0.6
Age at last live birth 0.3 0.4 0.8 0.9 -0.2 0.4 0.8
Family relationship satisfaction 1.4 1.7 3.1 1.3 1.3 0.7 1.7
Leg pain on walking 0.6 0.7 1.9 -0.4 1.4 0.8 0.5
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 2.5 -0.1 -1.4 -1.6 -1.6
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 0.4 -0.8 -0.8 -0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.5 0.2 -0.1 1.6 0.7
Medication: Aspirin 0.5 0.6 1.1 -1.0 -0.9 -0.2 -0.7
Supplements: Vitamin C 0.9 1.1 1.9 0.6 -1.4 0.2 -1.4
Knee pain experienced in last month 0.7 1.1 2.6 -0.9 0.3 -0.9 -1.6
Hypertension (Self-reported) 0.2 0.5 0.9 -1.0 -0.6 0.6 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 3.1 -1.8 0.1 0.1 -1.2
Illnesses of father: Heart disease 0.4 0.6 1.1 1.1 -0.9 0.6 -0.1
Illnesses of siblings: Diabetes 0.9 1.1 3.0 -1.7 0.4 0.8 0.8
Smoking status: Previous 0.3 0.5 1.0 -0.6 -1.0 -0.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.6 1.2 -0.9 0.2 -1.9
Whole body fat-free mass 4.1 23.7 33.5 -5.2 -3.2 -4.8 -5.8
Leg fat-free mass (right) 3.8 20.5 29.4 -4.4 -3.4 -4.7 -5.4
Arm fat percentage (left) 1.8 7.3 25.0 -5.0 -0.3 -1.3 -1.5
Average weekly red wine intake 3.9 5.7 9.0 2.1 2.5 3.0 1.8
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.0 0.4 0.8 1.4 1.4
Mood swings 3.1 5.5 11.2 1.4 2.2 2.0 3.3
Loneliness, isolation 1.5 2.1 3.8 1.3 1.6 0.1 2.0
Long-standing illness, disability or infirmity 0.3 0.5 1.3 -0.1 -0.1 -0.8 -1.1
Ever had bowel cancer screening 0.2 0.2 0.8 -0.2 -0.9 0.2 0.0
Diabetes diagnosed by doctor 1.2 1.9 4.8 -0.3 -0.9 -1.4 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.5 0.5 -0.3 -0.7 0.7
Friendships satisfaction 1.2 1.5 3.5 -0.0 1.1 1.1 1.9
Qualifications: nursing, teaching 0.8 1.2 3.1 -0.3 -0.7 -1.8 -1.0
Commuting to job workplace: Walk 0.6 0.6 1.0 0.6 1.0 0.9 0.5
Eye problems/disorders: Cataract 0.2 0.2 0.6 0.8 -0.0 0.4 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 2.3 1.5 1.5 1.4 0.7
Medication for cholesterol 0.9 1.3 3.3 1.8 -0.7 -1.2 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.5 0.5 -0.7 -0.7 -0.4
Back pain experienced in last month 1.0 1.5 5.0 -2.2 -0.0 -0.9 -0.3
Mineral and other dietary supplements 0.9 1.1 2.4 -0.6 1.6 0.5 1.2
Breast cancer (self-reported) 0.2 0.2 0.6 -0.7 -0.0 -0.4 0.1
Asthma (self-reported) 0.3 0.5 0.9 0.9 0.6 0.7 -0.5
Osteoporosis (self-reported) 0.4 0.5 1.2 0.4 -1.1 -0.8 -0.4
Osteoarthritis (self-reported) 2.2 2.8 6.6 -1.3 -1.4 -2.6 -1.1
Medication: Aspirin 0.2 0.3 0.6 -0.5 -0.7 -0.1 -0.7
Medication: Gliclazide 1.2 1.4 2.7 -1.1 -1.1 -0.6 -1.6
Illnesses of father: None of the above (group 1) 0.1 0.2 0.7 -0.8 -0.2 0.1 0.0
Smoking status: Current 1.8 2.9 5.5 -1.6 2.4 -0.1 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 5.8 0.3 2.4 1.7 1.8
Whole body water mass 3.8 21.7 30.6 -5.1 -3.0 -4.6 -5.5
Leg predicted mass (right) 3.8 20.5 29.4 -4.5 -3.3 -4.6 -5.4
Arm fat mass (left) 3.2 13.0 37.1 -6.1 -1.0 -2.4 -2.9
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 0.4 -0.3 -0.4 -0.5
Average weekly champagne plus white wine intake 1.2 1.6 3.2 0.2 1.8 1.5 1.0
Miserableness 2.2 3.9 10.0 1.0 1.8 1.2 3.2
Guilty feelings 5.1 7.7 17.1 -0.3 2.9 2.3 4.1
Wears glasses or contact lenses 1.2 1.4 2.7 1.1 1.0 0.7 1.6
Ever taken oral contraceptive pill 0.7 0.8 1.4 -1.2 0.9 0.5 0.8
Hearing aid user 0.2 0.3 0.8 0.9 -0.2 -0.1 -0.5
Mother’s age at death 1.4 1.8 3.1 -0.2 1.8 1.7 1.2
Financial situation satisfaction 0.2 0.2 0.3 -0.6 -0.2 -0.5 0.5
Tinnitus: Yes, now most or all of the time 0.6 0.7 0.9 0.8 0.8 1.0 -0.7
Commuting to job workplace: Public transport 0.1 0.1 0.4 0.0 0.2 0.3 0.6
Eye problems/disorders: Glaucoma 0.6 0.8 1.7 1.3 -0.1 0.5 1.0
Medication: Blood pressure 0.1 0.2 0.4 -0.6 -0.0 0.4 -0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.2 -1.1 0.3 -0.5 -0.5
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.3 -0.3 -1.0 0.2 -1.2
High cholesterol (Self-reported) 0.7 1.2 2.8 -1.7 -1.3 -0.5 -0.2
Medication: Bendroflumethiazide 0.2 0.2 0.7 -0.4 0.0 0.8 -0.3
Medication: Paracetamol 2.6 4.0 7.6 1.0 -1.7 -2.8 -2.1
Medication: Lisinopril 1.2 1.6 4.7 -2.2 -0.7 0.8 -0.6
Medication: Atorvastatin 1.6 1.9 3.6 -1.9 -0.5 -1.1 -1.6
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.3 0.1 -0.6 -0.1
Alcohol drinker status: Never 0.2 0.2 0.7 0.2 0.1 -0.4 -0.9
Ever smoked 0.9 1.5 3.2 -1.0 1.0 0.9 1.8
Basal metabolic rate 4.3 23.6 32.4 -5.5 -3.1 -4.7 -5.7
Leg fat percentage (left) 2.8 10.2 34.1 -5.8 -0.6 -2.2 -1.3
Arm fat-free mass (left) 4.5 22.9 35.8 -6.0 -2.9 -4.6 -5.1
Number of operations (self-reported) 0.4 0.6 1.7 -0.6 1.3 0.2 0.4
Average weekly beer plus cider intake 2.1 3.1 8.9 -3.0 -0.9 -1.6 -0.4
Irritability 1.4 2.3 3.6 1.5 1.9 1.2 1.5
Risk taking 0.8 1.1 2.7 -1.6 0.6 -0.7 1.0
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 0.2 0.1 -0.1 0.1
Fractured/broken bones in last 5 years 1.2 1.6 5.2 2.3 0.6 -0.5 -0.7
Age started oral contraceptive pill 0.7 0.8 1.7 -1.3 -0.4 0.3 -1.2
Diastolic blood pressure, automated reading 1.0 3.0 6.7 -2.6 -1.3 -0.6 -1.7
Ever depressed for a whole week 2.1 2.6 4.9 0.2 1.7 1.6 2.2
Unable to work because of sickness or disability 0.4 0.6 1.3 0.6 -0.2 -0.7 -1.1
Commuting to job workplace: Cycle 0.3 0.4 0.9 1.0 0.1 0.0 0.7
Myopia 0.7 1.1 1.6 1.3 0.8 1.0 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.9 1.6 1.3 1.1 -0.4 0.8
Cholesterol lowering medication 0.9 1.3 2.0 -1.4 -1.3 -0.8 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 -1.4 -0.5 -1.1 -0.0
Pain experienced in last month 0.8 1.3 3.1 0.8 -0.6 1.8 1.1
Supplements: Calcium 1.0 1.1 1.8 1.3 -1.3 -0.1 -1.0
Basal cell carcinoma (self-reported) 1.2 1.5 2.6 1.5 -1.0 0.2 -1.6
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.6 0.2 -0.4 -0.8 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.3 0.4 -0.0 0.5
Heart disease (siblings) 0.0 0.0 0.1 -0.1 0.1 -0.2 -0.2
Alcohol drinker status: Previous 0.3 0.4 0.5 0.4 -0.7 -0.6 -0.7
Pack years of smoking 2.0 2.9 7.0 -1.1 -1.4 -2.6 -1.1
Impedance of whole body 2.8 14.1 42.1 6.5 1.3 2.7 2.3
Leg fat mass (left) 4.0 15.7 42.2 -6.5 -1.7 -3.2 -2.8
Arm predicted mass (left) 4.4 22.2 34.0 -5.8 -2.9 -4.5 -5.1