Hub : Genes

NPTX1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0381	0.0127	0.00050	0.007	0.013	0.001	0.012	0.002	1.8e-03	2.6e-05	1.3e-01	6.2e-05	5.9e-02
2	TCGA	Lung Squamous Cell Carcinoma	0.0599	0.0260	0.00085	0.043	0.028	0.026	NA	0.035	1.0e-05	3.8e-04	5.6e-04	NA	7.4e-05
3	TCGA	Prostate Adenocarcinoma	0.0970	0.0436	0.00060	0.045	0.041	0.046	NA	0.044	1.7e-05	3.4e-05	1.4e-05	NA	1.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.4	2.8	-1.2	-0.0	-1.7
Bipolar Disorder or Schizophrenia	0.7	1.7	4.9	-0.0	-0.5	-2.2
Depressed Affect (Nagel 2018)	0.9	1.9	3.8	-1.4	-0.2	1.9
Depression (Nagel 2018)	1.2	1.8	2.8	-1.7	-0.8	1.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.5	-0.8	-0.3
Neuroticism (Nagel 2018)	0.8	2.0	4.7	-1.1	0.0	2.2
Schizophrenia (2018)	0.2	0.4	0.7	0.9	-0.6	0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	0.7	-1.1	0.0
Worry (Nagel 2018)	0.4	0.9	2.6	-0.1	0.1	1.6
Alzheimer’s Disease (in mother)	1.4	1.7	2.6	1.4	-1.6	0.7
Alzheimer’s Disease (in father)	0.3	0.4	0.8	0.0	-0.6	0.9
Alzheimer’s Disease (including proxy)	1.0	1.4	1.6	1.0	-1.3	1.3
Crohns Disease (2017)	0.6	1.4	1.9	-1.2	0.8	1.4
Irritable Bowel Disease (IBD)	0.6	1.5	3.8	-0.9	0.1	1.9
Ulcerative Colitis (UC)	0.5	1.0	1.5	0.2	-1.2	1.1
Major Depression (MDD)	0.1	0.1	0.2	-0.5	0.0	0.0
Reaction Time	0.2	0.4	0.7	0.2	0.9	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	-1.0	-1.1	-0.0
Breast Cancer	0.4	0.9	1.5	-0.2	1.2	-1.1
Ovarian Cancer	1.2	1.5	3.0	-1.7	0.6	-1.2
Prostate Cancer	0.9	1.3	2.2	1.2	-1.5	0.5
Age at First Birth	0.5	0.7	2.1	0.1	-0.3	-1.5
Bipolar Disorder (2011)	0.7	0.6	1.9	-1.4	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.6	2.8	0.7	1.7	1.2
Coronary Artery Disease (CAD)	2.1	2.5	5.4	1.4	-2.3	0.0
Crohns Disease (2012)	0.6	0.9	1.3	-1.1	1.0	0.6
Mean Putamen Volume	0.4	0.5	0.8	0.6	0.5	0.9
Fasting Glucose	0.3	0.4	1.0	0.2	0.4	-1.0
HbA1C	0.1	0.1	0.4	-0.2	-0.6	0.0
HDL Cholesterol	1.4	2.4	3.3	1.0	-1.8	1.7
LDL Cholesterol	0.8	1.2	3.2	-0.7	-0.1	-1.8
Lupus	0.1	0.1	0.3	-0.5	0.4	0.0
Neuroticism (2016)	1.5	2.1	5.0	-2.2	1.1	0.5
Primary Biliary Cirrhosis	1.0	1.5	2.5	1.6	0.3	-1.4
Rheumatoid Arthritis	1.5	2.1	5.7	2.4	-0.5	-0.6
Schizophrenia (2014)	0.2	0.4	1.0	0.5	-1.0	0.0
Triglycerides	1.2	2.0	3.2	-0.6	1.5	-1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	0.4	1.2	-0.9
Ulcerative Colitis	0.2	0.3	0.7	0.0	-0.8	0.2
Blood Eosinophil Count	0.0	0.2	0.3	-0.5	0.4	0.4
Blood Platelet Count	0.1	1.0	2.0	-1.4	-0.9	-0.3
Blood Red Count	0.1	1.0	2.3	0.6	-0.7	1.5
Blood White Count	0.3	2.5	6.2	-0.9	0.6	2.5
Heel T-Score	0.3	2.4	5.0	0.6	2.2	1.4
BMI	2.1	12.2	35.4	0.5	6.0	-1.1
Height	0.2	3.3	9.4	-3.1	0.5	0.3
Waist Hip Ratio (WHR)	0.4	1.6	4.9	0.2	-2.2	0.1
Systolic Blood Pressure	1.1	5.4	16.1	4.0	0.2	-0.2
Smoking Status	0.1	0.3	0.5	0.7	-0.4	0.5
Allergy or Eczema	0.5	1.3	3.6	-1.9	0.4	0.5
Cardiovascular Disease	0.5	1.7	2.9	1.7	1.4	0.4
Hypothyroidism (self reported)	0.0	0.1	0.1	0.4	-0.1	-0.2
Respiratory disease	0.1	0.2	0.5	-0.3	0.7	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.8	-0.6	0.8	0.9
Lung FEV1/FVC ratio	0.2	1.1	2.3	1.5	0.7	-0.8
Lung FVC	0.2	0.9	2.5	-1.6	0.4	0.2
Neuroticism	0.7	1.7	4.0	-1.1	0.3	2.0
Chronotype (morning person)	0.6	1.4	3.8	-0.4	0.5	-1.9
Hair Pigment	0.2	5.7	14.8	-1.5	3.9	-0.2
Tanning	0.1	1.3	3.8	-0.1	0.1	-1.9
Hand grip strength (left)	0.4	1.0	1.2	-1.1	0.8	1.1
Number of treatments/medications taken	0.9	1.6	2.9	-1.2	1.7	0.7
Average weekly spirits intake	0.3	0.4	0.9	-0.6	0.1	-0.9
Sensitivity / hurt feelings	0.3	0.5	0.9	0.9	0.5	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.8	0.8	-0.9	-0.9	0.9
Hearing difficulty/problems: Yes	0.9	1.4	3.0	-1.7	-1.0	0.3
Relative age of first facial hair	0.1	0.2	0.3	0.3	0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.9	-1.4	0.4	0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	0.9	0.0	1.4
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	-0.2	0.8	-0.9
Systolic blood pressure, automated reading	1.0	2.9	8.4	2.9	-0.0	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.7	0.6	1.3	-0.5
Angina	1.7	2.2	5.0	2.2	-0.8	0.9
Medication for hormone replacement therapy	0.3	0.4	1.1	1.0	-0.1	0.2
Vitamin and mineral supplements	1.3	1.8	4.9	0.3	-2.2	-0.7
Supplements: Zinc	1.0	1.1	2.6	-0.5	1.6	-0.6
Medication: Co-codamol	1.0	1.1	2.7	0.4	1.7	-0.7
Medication: Metformin	0.6	0.9	1.7	-0.9	1.3	0.3
Diabetes (father)	0.5	0.7	1.7	-1.3	-0.1	-0.6
Diabetes (mother)	0.4	0.5	1.3	-0.5	-1.1	0.1
Severe depression (siblings)	1.0	1.1	3.1	-1.8	0.4	0.0
Pack years adult smoking proportion	0.7	1.1	1.8	0.1	-1.3	1.2
Impedance of leg (right)	1.2	5.8	16.8	0.4	-4.1	0.7
Leg fat-free mass (left)	1.9	9.9	25.8	-1.9	5.1	-0.4
Trunk fat percentage	1.0	4.2	12.0	-0.6	3.5	0.2
Hand grip strength (right)	0.3	0.8	1.4	-0.8	1.2	0.6
Townsend deprivation index at recruitment	0.8	1.1	3.1	-1.8	-0.2	0.4
Current tobacco smoking	0.3	0.5	0.9	-0.7	0.1	0.9
Average weekly fortified wine intake	0.2	0.2	0.6	-0.1	-0.2	0.7
Maternal smoking around birth	1.5	2.2	5.6	2.4	-1.0	-0.1
Fed-up feelings	0.5	0.9	1.6	-0.9	-0.6	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	-0.1	-1.1	1.4
Relative age voice broke	0.6	0.9	1.3	1.1	1.1	-0.1
Taking other prescription medications	0.2	0.3	0.7	-0.4	0.8	-0.3
Age when periods started (menarche)	1.0	2.4	7.0	0.2	-2.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.5	1.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	2.7	-1.1	1.7	1.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.3	0.4	0.5
Qualifications: CSEs or equivalent	1.1	1.5	2.8	-1.7	1.1	0.6
Serious illness, injury or assault to yourself	2.2	2.6	3.7	-1.9	1.4	1.5
High blood pressure	0.5	1.4	2.5	1.1	0.7	1.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-0.7	1.2	0.3
Multivitamins +/- minerals	2.5	3.1	6.0	-1.8	2.5	0.3
Stomach or abdominal pain in last month	1.3	1.6	3.4	-1.8	0.9	0.7
Supplements: Glucosamine	0.6	0.8	1.7	-0.3	1.3	-0.8
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.8	-0.9	1.7	1.4
Medication: Atenolol	1.5	1.8	2.7	1.5	1.6	-0.7
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.3	-0.2	0.3
Sitting height	0.5	3.6	9.2	-3.0	1.0	0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.8	-0.4	-0.2
High blood pressure (mother)	1.5	2.1	3.4	0.5	1.9	1.6
Body mass index (BMI)	1.9	8.1	24.4	-0.2	4.9	0.1
Impedance of leg (left)	1.5	7.0	19.9	0.0	-4.5	1.1
Leg predicted mass (left)	1.8	9.4	24.6	-1.8	5.0	-0.4
Trunk fat mass	1.4	6.2	17.4	-1.0	4.2	0.3
Waist circumference	1.4	5.3	15.6	-0.5	4.0	-0.0
Number of incorrect matches in round	0.5	0.8	1.6	-1.3	0.7	0.4
Past tobacco smoking	0.2	0.3	0.6	-0.8	-0.0	0.5
Alcohol usually taken with meals	0.2	0.3	0.6	-0.5	0.4	0.8
Nervous feelings	0.8	1.5	4.3	-0.2	0.1	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.6	-0.3	0.7
Hearing difficulty/problems with background noise	2.3	3.7	5.5	-1.6	-1.7	2.4
Hair/balding pattern: Pattern 2	0.6	0.8	1.5	0.4	1.2	0.8
Had menopause	0.5	0.6	1.2	1.1	-0.5	0.5
Had other major operations	1.2	1.4	2.5	-1.6	-0.2	-1.3
Forced vital capacity (FVC)	0.8	2.9	6.0	-2.5	1.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.6	-0.7	1.3	1.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.0	-1.4	-0.5	0.5
Qualifications: None of the above	0.1	0.2	0.5	0.7	0.2	0.1
Financial difficulties in last 2 years	0.4	0.5	1.0	-0.1	1.0	0.8
Mouth/teeth dental problems	0.2	0.4	0.6	0.4	-0.8	-0.5
Heart attack	1.5	1.9	4.8	2.2	-0.6	-0.7
Allergy	0.3	0.6	1.6	-0.4	-1.3	0.5
Pain all over the body in last month	0.5	0.6	1.6	-1.3	0.3	-0.2
Diabetes (self-reported)	0.2	0.3	0.4	0.7	0.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	-0.2	0.2	-0.3
Medication: Ramipril	0.6	0.7	1.5	1.2	0.8	-0.0
Medication: Simvastatin	0.3	0.5	1.0	1.0	0.5	-0.2
Fluid intelligence score	0.5	1.1	2.6	0.1	-0.9	1.6
Illnesses of siblings	0.6	0.8	1.7	-1.3	0.7	-0.5
Neuroticism score	0.8	1.7	4.7	-0.6	0.4	2.2
Weight	1.9	9.5	25.7	-1.6	5.1	0.5
Impedance of arm (right)	1.1	5.3	13.5	1.3	-3.7	0.9
Arm fat percentage (right)	1.4	5.5	16.1	0.3	4.0	0.4
Trunk fat-free mass	1.0	6.0	13.8	-1.9	3.7	-0.6
Hip circumference	2.0	8.8	25.9	-0.6	5.1	0.1
Time employed in main current job	1.3	1.6	2.4	1.6	-1.5	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.2	0.2	0.7	-1.1
Father’s age at death	1.7	2.2	4.1	-2.0	1.6	0.3
Worrier / anxious feelings	0.9	1.7	4.0	-2.0	0.8	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.5	-1.2	-0.2	0.3
Falls in the last year	0.5	0.7	1.3	-0.7	-0.5	1.1
Hair/balding pattern: Pattern 3	2.0	2.9	4.3	-0.7	-2.0	2.1
Number of live births	0.1	0.2	0.3	-0.4	0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.5	-2.4	1.5	0.8
Pulse rate	1.7	2.8	8.1	-2.8	0.5	0.3
Happiness	1.3	1.6	4.4	2.1	-0.5	0.3
Noisy workplace	0.3	0.4	0.8	0.9	-0.5	0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.3	3.9	-2.0	1.7	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	4.4	-2.1	0.9	-1.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	0.2	0.9	-0.2
Asthma	0.3	0.6	1.3	0.3	0.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.8	-1.7	0.7	1.3
Medication: Cholesterol lowering	0.7	1.0	2.2	1.5	1.0	0.1
Depression (self-reported)	1.1	1.3	3.6	-1.9	0.5	-0.1
Medication: Lansoprazole	0.2	0.2	0.3	0.3	-0.5	0.5
Prospective memory result	0.3	0.4	0.8	-0.9	0.7	0.1
Lung cancer (father)	1.9	2.2	4.8	-2.2	-1.1	-0.8
Illnesses of mother	0.7	0.9	2.1	-1.4	-0.7	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.1	-2.2	1.5	1.2
Pulse wave Arterial Stiffness index	1.2	1.4	2.4	-1.5	0.1	1.3
Impedance of arm (left)	1.0	4.8	13.3	0.8	-3.6	0.8
Arm fat mass (right)	1.8	7.3	21.7	-0.4	4.7	0.3
Trunk predicted mass	1.1	6.1	14.0	-2.0	3.7	-0.7
Standing height	0.4	3.9	10.5	-3.2	0.9	0.7
Length of working week for main job	1.2	1.3	2.8	-0.3	-1.0	-1.7
Exposure to tobacco smoke at home	1.0	1.1	1.4	1.2	-1.1	-0.9
Breastfed as a baby	0.1	0.2	0.3	0.5	0.0	0.5
Tense / ‘highly strung’	1.9	3.2	5.1	2.0	-0.7	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.1	-2.2	-1.1	-0.2
Hair/balding pattern: Pattern 4	2.2	5.3	8.6	0.1	2.9	-2.7
Birth weight of first child	1.2	2.2	5.3	-2.3	1.0	-0.6
Peak expiratory flow (PEF)	1.6	3.6	6.5	-2.5	1.9	0.8
Pulse wave reflection index	0.2	0.2	0.3	0.6	-0.1	-0.5
Ever highly irritable/argumentative for 2 days	2.4	2.9	3.9	2.0	-1.7	1.4
Loud music exposure frequency	0.3	0.3	0.7	-0.8	0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.2	0.8	0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.0	0.5	-1.3	1.4
Blood clot in the leg (DVT)	1.1	1.4	2.8	-0.3	1.7	-1.2
Medication: Paracetamol	2.5	4.2	9.3	-3.0	1.7	-0.6
Headache pain in last month	0.4	0.6	1.6	-1.3	0.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.2	-0.9	-1.5	0.0
Glaucoma (self-reported)	0.4	0.4	0.8	0.1	0.9	-0.7
Gout (self-reported)	0.2	0.3	0.5	0.4	0.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.4	-0.2	-0.7
Medication: Amlodipine	0.4	0.6	1.0	-0.5	0.7	-1.0
Medication: Ventolin 100micrograms inhaler	1.8	2.3	6.5	2.5	0.0	-0.7
Birth weight	0.5	1.1	3.0	0.4	-1.7	0.2
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.9	-0.6	-0.6	-0.9
High blood pressure (siblings)	1.3	1.9	2.5	1.4	-1.1	1.6
Forced vital capacity (FVC), Best measure	0.9	3.4	6.2	-2.5	1.7	1.0
Body fat percentage	1.3	5.1	14.7	-0.6	3.8	0.4
Leg fat percentage (right)	1.3	4.7	13.8	0.1	3.7	0.5
Arm fat-free mass (right)	1.4	7.4	17.8	-2.1	4.2	-0.1
Exposure to tobacco smoke outside home	2.8	3.7	4.1	1.9	-1.8	2.0
Comparative body size at age 10	1.9	5.4	15.0	-0.8	3.9	-0.7
Number of full brothers	1.1	1.4	3.0	-1.0	1.7	-0.5
Worry too long after embarrassment	0.4	0.7	1.2	-0.9	-0.5	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	4.9	-2.2	-0.4	1.9
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.2	-0.5	-0.2
Number of children fathered	0.4	0.4	1.1	-0.3	0.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	2.8	-0.3	1.7	1.2
Age at first live birth	0.3	0.5	1.2	-0.7	0.0	1.1
Pulse wave peak to peak time	0.7	0.8	1.5	1.2	0.1	-0.9
Health satisfaction	0.1	0.1	0.3	-0.6	-0.1	0.1
Shortness of breath walking on level ground	0.2	0.2	0.4	0.3	0.5	0.6
Qualifications: College or University degree	0.3	1.1	2.9	-1.7	-0.4	0.5
Eye problems/disorders: None of the above	0.5	0.5	1.2	0.6	-1.1	-0.0
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.5	-1.9	-0.5	0.4
Emphysema/chronic bronchitis	2.0	2.2	2.4	1.5	-1.5	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	1.9	1.3	-1.4	-0.0
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.3	0.0	-0.0
Medication: Blood pressure	0.9	1.5	2.4	1.1	1.6	1.0
Angina (self-reported)	1.6	2.0	5.1	2.2	-0.6	0.8
Migraine (self-reported)	0.2	0.2	0.4	-0.4	0.4	0.6
Medication: Ibuprofen	2.1	2.5	3.9	-2.0	1.1	1.5
Medication: Allopurinol	0.1	0.1	0.1	0.4	0.4	-0.3
Medication: Omeprazole	0.8	0.9	2.4	-0.3	1.6	0.5
Medication: Seretide 50 evohaler	1.4	1.6	4.7	2.2	0.2	-0.1
Mean time to correctly identify matches	0.4	0.7	1.0	0.3	1.0	-1.0
Heart disease (mother)	1.4	1.7	3.2	1.2	1.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	0.7	0.4	0.7
Whole body fat mass	1.7	7.2	20.7	-0.9	4.5	0.5
Leg fat mass (right)	2.1	8.2	23.6	-0.7	4.9	0.6
Arm predicted mass (right)	1.4	7.1	17.3	-2.0	4.2	-0.4
Pulse rate, automated reading	0.3	1.1	2.3	-1.5	-1.0	0.3
Alcohol intake frequency.	0.3	0.7	1.2	-0.8	0.5	-1.1
Comparative height size at age 10	0.4	2.0	2.8	-1.7	1.3	1.3
Number of full sisters	0.4	0.5	1.2	-1.1	-0.3	0.2
Suffer from ‘nerves’	0.4	0.6	1.1	0.4	-0.6	1.0
Overall health rating	0.1	0.3	0.7	-0.8	-0.1	-0.5
Chest pain or discomfort	0.6	0.8	1.5	0.6	-1.2	0.7
Had major operations	0.4	0.5	1.0	0.7	1.0	-0.3
Age at last live birth	1.1	1.6	2.4	-1.5	-0.2	1.6
Family relationship satisfaction	1.2	1.5	2.2	1.5	-1.0	-1.1
Leg pain on walking	0.1	0.1	0.2	-0.0	-0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	-0.5	-0.9	-0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	0.9	-1.4	-0.7
Illness, injury, bereavement, stress in last 2 years	3.2	3.9	6.5	1.9	-2.5	-1.3
Medication: Aspirin	1.9	2.5	4.6	1.6	2.1	-0.7
Supplements: Vitamin C	1.3	1.5	3.8	-0.2	0.8	1.9
Knee pain experienced in last month	0.7	1.1	2.4	-1.6	-0.7	-0.5
Hypertension (Self-reported)	0.6	1.8	2.8	1.7	0.7	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.0	-0.6	1.3	1.7
Illnesses of father: Heart disease	1.7	2.4	3.8	-0.8	1.6	-1.9
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.3	-0.6	-0.2
Smoking status: Previous	0.5	0.8	1.8	0.4	0.7	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.2	-1.8	1.2	-0.1
Whole body fat-free mass	1.4	8.3	20.7	-2.0	4.5	-0.4
Leg fat-free mass (right)	1.6	8.7	22.3	-1.9	4.7	-0.1
Arm fat percentage (left)	1.3	5.3	15.8	0.0	4.0	0.4
Average weekly red wine intake	1.2	1.8	3.3	-1.3	0.5	1.8
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.8	-0.7	0.2	-1.3
Mood swings	0.5	0.8	2.1	-0.7	0.2	1.4
Loneliness, isolation	0.2	0.3	0.5	-0.7	-0.5	-0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.0	-0.0	-0.4
Ever had bowel cancer screening	1.1	1.3	1.4	-1.2	-1.1	1.0
Diabetes diagnosed by doctor	0.2	0.4	0.6	-0.2	0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.3	-0.6	0.4	0.6
Friendships satisfaction	0.4	0.5	1.4	-0.3	-0.3	1.2
Qualifications: nursing, teaching	1.4	2.2	5.1	1.2	0.4	2.3
Commuting to job workplace: Walk	0.8	0.8	1.3	-0.4	1.1	1.0
Eye problems/disorders: Cataract	1.3	1.5	4.1	-2.0	-0.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	-0.3	0.5	-1.0
Medication for cholesterol	0.5	0.8	1.6	-0.6	-0.6	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	5.3	-0.3	2.3	-0.6
Back pain experienced in last month	0.2	0.2	0.4	-0.2	-0.6	0.6
Mineral and other dietary supplements	1.5	2.0	4.7	1.2	-2.2	-0.0
Breast cancer (self-reported)	0.7	0.9	1.5	1.2	0.9	-0.4
Asthma (self-reported)	0.3	0.5	1.1	0.2	1.1	-0.7
Osteoporosis (self-reported)	0.7	0.8	1.9	0.6	-0.6	-1.4
Osteoarthritis (self-reported)	0.5	0.6	1.0	1.0	-0.2	0.9
Medication: Aspirin	1.5	1.9	4.3	1.0	2.1	-0.6
Medication: Gliclazide	0.9	1.0	2.0	0.6	1.4	-0.7
Illnesses of father: None of the above (group 1)	1.9	2.3	3.2	0.7	-1.8	1.8
Smoking status: Current	0.3	0.4	1.1	-0.3	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.4	-0.6	0.6	-0.6
Whole body water mass	1.5	8.7	21.7	-2.1	4.7	-0.4
Leg predicted mass (right)	1.7	9.0	22.9	-2.0	4.8	-0.1
Arm fat mass (left)	1.7	7.0	20.7	-0.4	4.6	0.3
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	-1.0	1.4	0.5
Average weekly champagne plus white wine intake	2.1	2.9	4.5	-2.1	1.8	0.9
Miserableness	0.9	1.5	4.0	-0.2	-0.7	2.0
Guilty feelings	2.0	2.9	4.6	-0.6	2.0	2.1
Wears glasses or contact lenses	0.4	0.5	1.1	-0.3	-0.4	-1.1
Ever taken oral contraceptive pill	1.2	1.4	2.9	-1.0	-0.4	1.7
Hearing aid user	0.1	0.1	0.2	0.2	-0.4	-0.0
Mother’s age at death	0.6	0.8	1.9	1.4	-0.2	-0.6
Financial situation satisfaction	0.2	0.2	0.5	-0.4	-0.1	0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.6	-0.4	-0.2	1.6
Commuting to job workplace: Public transport	1.0	1.2	1.6	-0.7	1.2	1.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	1.0	1.5	0.5
Medication: Blood pressure	0.6	1.2	2.9	0.7	0.4	1.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.3	-0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.9	0.3	1.7	-0.3
High cholesterol (Self-reported)	0.6	1.1	2.2	0.9	1.5	0.5
Medication: Bendroflumethiazide	0.3	0.4	1.1	1.1	-0.0	0.4
Medication: Paracetamol	3.9	6.0	12.2	-3.5	2.3	-0.6
Medication: Lisinopril	0.6	0.8	2.0	-0.0	1.4	0.6
Medication: Atorvastatin	0.5	0.6	0.8	0.8	0.5	0.9
Illnesses of father: High blood pressure	0.7	0.8	2.3	-0.4	-0.1	-1.5
Alcohol drinker status: Never	1.0	1.2	2.8	0.9	-1.7	-0.1
Ever smoked	0.1	0.2	0.4	0.7	0.2	-0.1
Basal metabolic rate	1.6	9.0	22.8	-2.0	4.8	-0.3
Leg fat percentage (left)	1.3	4.7	13.4	-0.3	3.7	0.8
Arm fat-free mass (left)	1.8	9.0	23.3	-1.7	4.8	-0.8
Number of operations (self-reported)	0.5	0.7	1.4	-1.2	0.7	0.4
Average weekly beer plus cider intake	1.0	1.5	3.6	1.9	-0.5	-0.8
Irritability	2.0	3.4	6.2	-0.8	-2.5	1.8
Risk taking	0.2	0.3	0.9	0.1	-0.9	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.4	0.3	1.5	-0.3
Fractured/broken bones in last 5 years	0.4	0.5	0.9	-0.6	-0.9	0.6
Age started oral contraceptive pill	0.2	0.3	0.6	0.1	0.5	0.8
Diastolic blood pressure, automated reading	0.3	0.8	1.7	1.3	0.2	0.8
Ever depressed for a whole week	1.2	1.4	2.9	-1.2	-0.2	1.7
Unable to work because of sickness or disability	0.8	1.0	1.5	-1.2	-0.8	1.0
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.1	0.6	-0.1
Myopia	0.4	0.5	1.1	-1.0	0.5	-0.5
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.5	-1.9	-0.6	-1.4
Cholesterol lowering medication	0.6	1.0	1.4	-0.4	1.2	1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	-1.0	0.3	0.9
Pain experienced in last month	0.9	1.6	4.4	2.1	-0.5	0.1
Supplements: Calcium	0.4	0.4	1.2	-1.1	0.2	-0.0
Basal cell carcinoma (self-reported)	1.0	1.1	3.3	-1.8	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.8	2.4	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.3	-0.2	1.5	-1.3
Heart disease (siblings)	0.3	0.3	0.9	-0.2	-1.0	-0.1
Alcohol drinker status: Previous	1.1	1.3	3.1	-1.8	0.7	-0.5
Pack years of smoking	0.8	1.2	2.2	0.7	-1.5	0.9
Impedance of whole body	1.3	6.6	17.6	0.6	-4.2	1.3
Leg fat mass (left)	2.0	7.9	22.3	-0.9	4.7	0.8
Arm predicted mass (left)	1.6	8.2	20.9	-1.8	4.6	-0.6