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chr5:73,626,450-76,317,553

Best TWAS P=1.02e-43 · Best GWAS P=1.23e-47 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	-13.7	13.9	1.0e-43	-0.90	0.29	0.71	TRUE
6	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	-9.5	-11.6	2.6e-31	0.49	0.06	0.83	TRUE
22	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	-8.9	-11.3	2.0e-29	0.72	0.18	0.34	TRUE
9	GTEx	Brain Cerebellar Hemisphere	POC5	0.31	0.15	enet	18	0.30	1.6e-08	-8.9	-10.4	1.5e-25	0.61	0.61	0.23	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	POC5	0.05	0.00	blup	384	0.02	8.6e-04	-9.0	-9.4	4.6e-21	0.57	0.30	0.13	TRUE
5	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	-9.0	-9.1	1.5e-19	0.60	0.82	0.07	TRUE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GCNT4	0.17	0.00	blup	50	0.05	1.5e-06	-7.5	-5.8	7.1e-09	0.27	0.01	0.03	TRUE
17	GTEx	Lung	POC5	0.18	0.09	enet	46	0.09	2.5e-07	-8.9	-5.4	6.1e-08	0.24	0.98	0.00	TRUE
30	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	-11.4	-13.0	1.7e-38	0.81	0.27	0.63	FALSE
20	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	-7.2	-12.2	4.4e-34	0.59	0.17	0.19	FALSE
29	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	-12.3	-12.0	2.0e-33	0.58	0.97	0.02	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	-7.5	11.6	3.9e-31	-0.63	0.08	0.54	FALSE
8	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	-9.8	-11.1	1.2e-28	0.64	0.35	0.14	FALSE
27	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	-11.1	-11.0	3.5e-28	0.62	0.32	0.13	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	-13.7	11.0	5.5e-28	-0.77	0.02	0.57	FALSE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	-10.4	-10.9	9.2e-28	0.57	0.02	0.72	FALSE
25	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	-10.0	-10.9	1.1e-27	0.50	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	-7.9	10.5	7.6e-26	-0.57	0.32	0.43	FALSE
12	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	-9.6	10.3	9.2e-25	-0.61	0.25	0.46	FALSE
38	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	-10.5	-10.1	5.4e-24	0.73	0.05	0.80	FALSE
7	GTEx	Artery Tibial	GCNT4	0.08	0.07	lasso	2	0.04	3.9e-04	-9.5	9.6	6.1e-22	-0.44	0.68	0.07	FALSE
15	GTEx	Esophagus Mucosa	COL4A3BP	0.09	0.06	lasso	5	0.05	4.2e-04	-7.6	9.6	1.1e-21	-0.51	0.80	0.04	FALSE
24	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	-9.8	9.4	5.5e-21	-0.65	0.60	0.19	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANKRD31	0.10	0.13	lasso	9	0.13	3.9e-15	-10.2	9.3	1.0e-20	-0.33	1.00	0.00	FALSE
10	GTEx	Brain Hypothalamus	CTC-366B18.4	0.26	0.12	lasso	8	0.07	9.0e-03	-8.9	9.2	3.8e-20	-0.56	0.10	0.09	FALSE
19	GTEx	Pancreas	POC5	0.32	0.23	lasso	3	0.21	3.5e-09	-9.0	-9.1	6.1e-20	0.57	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	POC5	0.08	0.07	lasso	7	0.07	3.2e-06	-8.9	-9.1	8.9e-20	0.56	0.96	0.00	FALSE
21	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	-8.9	-9.1	1.3e-19	0.57	0.95	0.03	FALSE
18	GTEx	Nerve Tibial	POC5	0.16	0.12	lasso	5	0.10	7.6e-08	-9.0	-9.0	1.7e-19	0.57	0.99	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	POC5	0.15	0.17	lasso	6	0.16	3.4e-12	-9.0	-9.0	2.2e-19	0.57	1.00	0.00	FALSE
16	GTEx	Esophagus Mucosa	POC5	0.18	0.16	lasso	1	0.15	4.8e-10	-9.0	-9.0	2.2e-19	0.57	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	GCNT4	0.10	0.06	enet	6	0.05	8.7e-04	-5.0	8.9	4.3e-19	-0.41	0.08	0.52	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	POC5	0.47	0.36	lasso	4	0.39	1.3e-13	-8.9	-8.8	1.0e-18	0.57	1.00	0.00	FALSE
26	GTEx	Thyroid	POC5	0.26	0.23	enet	15	0.23	1.8e-17	-9.0	-7.8	4.1e-15	0.49	1.00	0.00	FALSE
28	METSIM	Adipose	POC5	0.11	0.09	enet	29	0.10	7.5e-15	-9.0	-7.5	4.9e-14	0.48	1.00	0.00	FALSE
23	GTEx	Stomach	POC5	0.10	0.06	enet	12	0.08	8.3e-05	-9.6	-7.5	6.0e-14	0.43	0.56	0.02	FALSE
14	GTEx	Colon Transverse	POC5	0.23	0.16	lasso	4	0.18	6.0e-09	-9.0	-6.7	2.9e-11	0.39	0.96	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SV2C	0.11	0.07	bslmm	660	0.07	4.0e-09	-3.8	-6.2	4.8e-10	0.32	1.00	0.00	FALSE