Best TWAS P=1.19e-18 · Best GWAS P=3.16e-18 conditioned to 0.0326
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SIDT2 | 0.07 | 0.06 | lasso | 5 | 0.05 | 8.8e-07 | 6.206 | -6.7 | 2.1e-11 | -0.29 | 0.99 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNF259 | 0.08 | 0.03 | enet | 6 | 0.03 | 1.2e-04 | 7.207 | -8.8 | 1.2e-18 | -0.76 | 0.03 | 0.97 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | PAFAH1B2 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.3e-01 | 6.845 | -7.1 | 1.2e-12 | -0.42 | 0.06 | 0.20 | TRUE |
| 4 | GTEx | Colon Sigmoid | PCSK7 | 0.28 | 0.09 | lasso | 8 | 0.15 | 6.5e-06 | 6.770 | -6.2 | 4.9e-10 | -0.39 | 0.82 | 0.02 | FALSE |
| 5 | GTEx | Esophagus Muscularis | PCSK7 | 0.18 | 0.09 | lasso | 3 | 0.10 | 9.2e-07 | 6.256 | -5.8 | 8.6e-09 | -0.24 | 0.97 | 0.00 | FALSE |
| 6 | GTEx | Pancreas | SIDT2 | 0.17 | 0.12 | lasso | 3 | 0.08 | 1.9e-04 | 6.250 | -6.1 | 1.3e-09 | -0.24 | 0.38 | 0.05 | FALSE |
| 7 | GTEx | Testis | TAGLN | 0.15 | 0.05 | lasso | 5 | 0.04 | 8.0e-03 | 6.077 | -6.9 | 6.2e-12 | -0.32 | 0.36 | 0.04 | FALSE |
| 8 | GTEx | Whole Blood | SIDT2 | 0.18 | 0.06 | lasso | 7 | 0.04 | 2.3e-04 | 6.256 | -6.4 | 1.9e-10 | -0.24 | 0.95 | 0.00 | FALSE |
| 9 | METSIM | Adipose | SIDT2 | 0.09 | 0.07 | lasso | 7 | 0.07 | 2.3e-10 | 6.256 | -6.3 | 3.5e-10 | -0.30 | 1.00 | 0.00 | FALSE |
| 10 | METSIM | Adipose | TAGLN | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.8e-06 | 6.256 | -5.8 | 7.3e-09 | -0.22 | 0.97 | 0.00 | FALSE |
| 11 | NTR | Blood | SIDT2 | 0.12 | 0.15 | lasso | 4 | 0.15 | 2.3e-46 | 6.256 | -5.8 | 6.5e-09 | -0.22 | 1.00 | 0.00 | FALSE |
| 12 | YFS | Blood | SIDT2 | 0.40 | 0.40 | enet | 46 | 0.46 | 1.3e-168 | 6.250 | -5.4 | 6.0e-08 | -0.21 | 1.00 | 0.00 | FALSE |
| 13 | YFS | Blood | TAGLN | 0.37 | 0.47 | enet | 47 | 0.54 | 1.3e-213 | 3.995 | -5.3 | 1.2e-07 | -0.25 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PCSK7 | 0.04 | 0.02 | blup | 51 | 0.02 | 4.4e-03 | 3.678 | 5.6 | 1.9e-08 | 0.25 | 0.01 | 0.95 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | SIDT2 | 0.11 | 0.00 | blup | 46 | 0.05 | 8.2e-04 | 6.256 | -6.4 | 1.9e-10 | -0.25 | 0.01 | 0.65 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PCSK7 | 0.04 | 0.03 | lasso | 3 | 0.03 | 5.6e-04 | 6.206 | 6.3 | 2.5e-10 | 0.26 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SIDT2 | 0.08 | 0.01 | blup | 46 | 0.05 | 2.4e-06 | 6.068 | -6.0 | 2.2e-09 | -0.21 | 0.02 | 0.89 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | SIDT2 | 0.02 | 0.01 | blup | 46 | 0.01 | 4.6e-02 | 4.253 | -5.9 | 3.1e-09 | -0.26 | 0.01 | 0.82 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF259 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.4e-04 | 7.028 | -7.2 | 4.5e-13 | -0.48 | 0.19 | 0.08 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | BUD13 | 0.08 | 0.00 | blup | 76 | 0.01 | 9.2e-02 | -0.058 | -5.2 | 2.2e-07 | -0.22 | 0.02 | 0.04 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIDT2 | 0.03 | 0.03 | blup | 46 | 0.03 | 2.4e-04 | 6.256 | -5.2 | 2.6e-07 | -0.21 | 0.01 | 0.97 | FALSE |