Best TWAS P=3.74e-09 · Best GWAS P=3.67e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | LSMD1 | 0.28 | 0.12 | lasso | 5 | 0.19 | 3.3e-09 | 5.9 | 5.8 | 5.2e-09 | 0.89 | 0.00 | 0.99 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | KDM6B | 0.07 | 0.05 | lasso | 4 | 0.04 | 2.7e-06 | 5.9 | -5.2 | 1.6e-07 | -0.95 | 0.00 | 1.00 | FALSE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYB5D1 | 0.14 | 0.12 | lasso | 1 | 0.10 | 1.7e-06 | 5.9 | -5.9 | 3.7e-09 | -1.00 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFSF12 | 0.04 | 0.01 | enet | 9 | 0.01 | 4.3e-02 | 4.3 | -5.1 | 3.1e-07 | -0.08 | 0.01 | 0.49 | TRUE |