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chr17:27,222,988-29,985,248

Best TWAS P=6.7e-10 · Best GWAS P=2.03e-08 conditioned to 0.342

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CRLF3	0.22	0.26	lasso	4	0.27	8.4e-33	-5.4	5.5	4.1e-08	-0.94	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	CRLF3	0.13	0.13	enet	9	0.14	8.1e-12	-5.4	5.2	1.5e-07	-0.92	0.02	0.98	FALSE
3	GTEx	Artery Aorta	SUZ12P	0.16	0.16	lasso	20	0.16	2.3e-09	-5.2	5.2	1.8e-07	-0.89	0.06	0.94	FALSE
4	GTEx	Artery Coronary	CRLF3	0.15	0.07	lasso	6	0.06	5.8e-03	-5.3	5.4	5.5e-08	-0.96	0.04	0.88	FALSE
5	GTEx	Brain Caudate basal ganglia	TEFM	0.27	0.19	enet	41	0.20	2.7e-06	-5.1	5.1	2.7e-07	-0.85	0.07	0.90	FALSE
6	GTEx	Brain Caudate basal ganglia	SUZ12P	0.35	0.36	enet	24	0.32	7.0e-10	-5.2	5.2	1.5e-07	-0.88	0.05	0.94	FALSE
7	GTEx	Brain Cerebellar Hemisphere	CRLF3	0.38	0.35	enet	26	0.35	6.0e-10	-4.6	5.2	2.3e-07	-0.81	0.07	0.93	FALSE
8	GTEx	Brain Cerebellar Hemisphere	SUZ12P	0.40	0.29	enet	55	0.32	4.0e-09	-5.4	5.8	5.4e-09	-0.89	0.06	0.93	FALSE
9	GTEx	Brain Cerebellum	ADAP2	0.11	0.13	lasso	3	0.12	2.6e-04	-5.2	-5.2	2.4e-07	0.86	0.06	0.83	FALSE
10	GTEx	Brain Cortex	TEFM	0.13	0.15	lasso	16	0.12	2.6e-04	-5.4	5.4	6.1e-08	-0.95	0.06	0.75	FALSE
11	GTEx	Brain Cortex	SUZ12P	0.15	0.16	lasso	10	0.15	5.7e-05	-5.2	5.2	1.6e-07	-0.86	0.05	0.89	FALSE
12	GTEx	Brain Frontal Cortex BA9	SUZ12P	0.18	0.24	enet	22	0.24	5.0e-07	-5.2	5.2	1.9e-07	-0.87	0.05	0.94	FALSE
13	GTEx	Brain Hippocampus	SUZ12P	0.23	0.23	lasso	11	0.22	7.6e-06	-5.2	5.2	1.8e-07	-0.86	0.06	0.91	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	CRLF3	0.19	0.23	lasso	9	0.22	2.0e-06	-5.2	5.2	2.3e-07	-0.86	0.06	0.93	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	SUZ12P	0.34	0.32	lasso	9	0.32	2.9e-09	-5.2	5.2	2.4e-07	-0.86	0.05	0.94	FALSE
16	GTEx	Breast Mammary Tissue	CRLF3	0.10	0.10	lasso	3	0.05	9.6e-04	-5.3	5.4	6.7e-08	-0.87	0.03	0.88	FALSE
17	GTEx	Breast Mammary Tissue	SUZ12P	0.16	0.14	lasso	2	0.14	8.8e-08	-5.2	5.3	8.9e-08	-0.88	0.04	0.95	FALSE
18	GTEx	Cells Transformed fibroblasts	SUZ12P	0.25	0.24	lasso	11	0.24	3.7e-18	-5.1	5.2	2.0e-07	-0.85	0.05	0.95	FALSE
19	GTEx	Colon Transverse	SUZ12P	0.21	0.15	lasso	3	0.15	9.8e-08	-5.1	5.2	2.6e-07	-0.86	0.05	0.95	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	CRLF3	0.08	0.09	lasso	5	0.04	1.0e-02	-5.1	5.2	1.8e-07	-0.91	0.06	0.79	FALSE
21	GTEx	Esophagus Mucosa	SUZ12P	0.21	0.16	lasso	15	0.13	3.0e-09	-5.2	5.4	5.3e-08	-0.89	0.05	0.95	FALSE
22	GTEx	Esophagus Muscularis	SUZ12P	0.17	0.18	lasso	9	0.19	9.8e-12	-5.2	5.1	2.9e-07	-0.86	0.05	0.95	FALSE
23	GTEx	Heart Left Ventricle	SUZ12P	0.09	0.08	enet	42	0.09	1.9e-05	-5.2	5.2	1.6e-07	-0.91	0.06	0.94	FALSE
24	GTEx	Lung	CRLF3	0.11	0.11	lasso	7	0.10	5.0e-08	-5.2	5.3	1.4e-07	-0.88	0.05	0.95	FALSE
25	GTEx	Lung	SUZ12P	0.13	0.17	lasso	11	0.19	8.0e-15	-5.4	5.4	6.6e-08	-0.93	0.04	0.96	FALSE
26	GTEx	Muscle Skeletal	TEFM	0.07	0.08	lasso	19	0.08	2.4e-08	-5.1	5.1	2.8e-07	-0.94	0.07	0.93	FALSE
27	GTEx	Nerve Tibial	ATAD5	0.07	0.04	lasso	10	0.05	1.4e-04	-5.4	-5.2	1.6e-07	0.95	0.06	0.93	FALSE
28	GTEx	Nerve Tibial	CRLF3	0.38	0.16	lasso	14	0.19	3.0e-13	-5.2	5.3	1.5e-07	-0.83	0.05	0.95	FALSE
29	GTEx	Nerve Tibial	SUZ12P	0.25	0.34	enet	44	0.35	1.1e-25	-5.2	5.4	8.2e-08	-0.85	0.05	0.95	FALSE
30	GTEx	Ovary	CRLF3	0.21	0.14	lasso	4	0.11	1.0e-03	-5.2	5.2	2.4e-07	-0.80	0.04	0.68	FALSE
31	GTEx	Ovary	SUZ12P	0.29	0.26	lasso	10	0.24	1.1e-06	-5.2	5.2	1.8e-07	-0.87	0.05	0.93	FALSE
32	GTEx	Pancreas	SUZ12P	0.10	0.13	lasso	6	0.09	1.6e-04	-5.2	5.2	2.4e-07	-0.86	0.05	0.91	FALSE
33	GTEx	Prostate	CRLF3	0.26	0.09	lasso	14	0.14	2.7e-04	-5.4	5.2	2.0e-07	-0.89	0.03	0.90	FALSE
34	GTEx	Skin Sun Exposed Lower leg	TEFM	0.08	0.09	enet	25	0.09	1.4e-07	-5.4	5.1	2.7e-07	-0.95	0.05	0.95	FALSE
35	GTEx	Skin Sun Exposed Lower leg	SUZ12P	0.13	0.17	lasso	17	0.15	2.1e-12	-5.2	5.2	1.7e-07	-0.87	0.05	0.95	FALSE
36	GTEx	Stomach	SUZ12P	0.19	0.10	lasso	8	0.09	5.4e-05	-5.2	5.3	1.4e-07	-0.85	0.06	0.94	FALSE
37	GTEx	Thyroid	CRLF3	0.10	0.04	enet	35	0.08	1.1e-06	-5.2	5.5	4.6e-08	-0.85	0.05	0.95	FALSE
38	GTEx	Thyroid	ANKRD13B	0.23	0.12	lasso	6	0.18	2.3e-13	-4.8	-5.1	2.9e-07	0.12	0.10	0.89	TRUE
39	GTEx	Thyroid	SUZ12P	0.27	0.29	enet	26	0.29	8.6e-23	-5.2	5.2	2.3e-07	-0.87	0.05	0.95	FALSE
40	METSIM	Adipose	CTD-2349P21.5	0.02	0.00	bslmm	252	0.01	3.0e-03	2.8	6.2	6.7e-10	-0.71	0.04	0.24	TRUE
41	NTR	Blood	CRLF3	0.02	0.03	enet	18	0.02	8.0e-08	-5.2	5.2	1.5e-07	-0.87	0.04	0.95	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf42	0.04	0.07	lasso	4	0.07	9.6e-14	-5.1	5.2	2.3e-07	-0.94	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CRLF3	0.11	0.03	blup	38	0.07	2.9e-04	-5.6	5.3	1.4e-07	-0.92	0.02	0.90	FALSE
44	The Cancer Genome Atlas	Esophageal Carcinoma	CCDC55	0.27	0.00	blup	64	0.00	3.5e-01	-1.4	5.5	5.1e-08	-0.07	0.01	0.18	FALSE
45	The Cancer Genome Atlas	Glioblastoma Multiforme	SUZ12P	0.18	0.14	blup	25	0.12	1.8e-04	-5.2	5.2	1.6e-07	-0.84	0.01	0.96	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf42	0.01	0.02	enet	4	0.02	6.2e-03	-5.3	5.3	1.0e-07	-0.97	0.01	0.73	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SUZ12P	0.06	0.05	lasso	3	0.05	1.2e-06	-5.1	5.4	5.9e-08	-0.78	0.01	0.98	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRLF3	0.08	0.04	lasso	5	0.07	7.9e-08	-5.1	5.4	6.8e-08	-0.84	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRC37B2	0.06	0.08	lasso	5	0.08	1.6e-09	-5.3	5.2	2.1e-07	-0.87	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUZ12P	0.08	0.11	lasso	1	0.11	2.7e-12	-5.3	5.3	1.2e-07	-0.88	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUZ12P	0.19	0.24	lasso	8	0.26	4.7e-29	-5.2	5.2	2.5e-07	-0.86	0.01	0.98	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	SUZ12P	0.04	0.03	lasso	8	0.03	3.3e-04	-5.2	5.2	2.5e-07	-0.86	0.01	0.97	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CRLF3	0.08	0.04	lasso	9	0.03	7.2e-05	-5.2	5.2	1.9e-07	-0.86	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CRLF3	0.04	0.02	blup	39	0.04	1.7e-03	-5.1	5.5	3.8e-08	-0.93	0.04	0.82	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CRLF3	0.07	0.06	blup	40	0.06	2.0e-03	-5.2	5.5	4.2e-08	-0.89	0.03	0.74	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SUZ12P	0.09	0.05	blup	29	0.05	3.2e-03	-5.2	5.5	3.7e-08	-0.81	0.01	0.84	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CRLF3	0.28	0.13	blup	40	0.11	3.1e-05	-5.6	5.4	6.4e-08	-0.87	0.01	0.97	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	CRLF3	0.02	0.02	blup	39	0.02	2.7e-03	-5.2	5.7	1.3e-08	-0.90	0.03	0.68	FALSE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	SUZ12P	0.04	0.05	enet	5	0.04	2.2e-03	-5.2	5.2	1.5e-07	-0.85	0.01	0.82	FALSE
60	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C17orf42	0.10	0.10	lasso	3	0.08	3.3e-03	-5.3	5.2	1.5e-07	-0.97	0.01	0.65	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	CRLF3	0.03	0.02	blup	40	0.03	5.7e-03	-5.4	5.5	3.7e-08	-0.93	0.02	0.78	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	EFCAB5	0.06	0.02	blup	80	0.02	1.1e-02	-4.9	-5.3	1.0e-07	-0.02	0.02	0.48	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUZ12P	0.05	0.05	blup	29	0.04	5.1e-04	-5.3	5.4	5.7e-08	-0.85	0.01	0.93	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ATAD5	0.02	0.02	blup	52	0.02	1.2e-02	-5.3	-5.5	3.8e-08	0.97	0.02	0.66	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	CRLF3	0.04	0.08	lasso	19	0.07	2.0e-07	-5.1	5.1	2.7e-07	-0.93	0.06	0.94	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	GIT1	0.06	0.05	blup	47	0.05	5.2e-06	4.7	-5.2	2.1e-07	0.10	0.00	0.98	FALSE