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chr17:73,128,150-74,629,867

Best TWAS P=6.44e-11 · Best GWAS P=7.57e-12 conditioned to 0.0386

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TRIM65	0.10	0.07	lasso	4	0.05	3.0e-05	-5.4	-5.5	4.0e-08	0.77	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	FBF1	0.36	0.29	lasso	2	0.29	5.4e-24	-6.5	-6.5	8.9e-11	0.89	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	MRPL38	0.08	0.07	lasso	4	0.06	9.3e-06	-5.5	6.1	9.9e-10	-0.88	0.04	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	FBF1	0.29	0.23	lasso	1	0.22	1.4e-11	-6.5	-6.5	1.1e-10	0.88	0.01	0.99	FALSE
5	GTEx	Artery Aorta	FBF1	0.32	0.27	lasso	2	0.26	2.2e-14	-6.5	-6.4	1.3e-10	0.89	0.01	0.99	FALSE
6	GTEx	Artery Coronary	FBF1	0.41	0.18	lasso	8	0.14	2.2e-05	-6.5	-5.9	4.0e-09	0.86	0.01	0.99	FALSE
7	GTEx	Artery Tibial	FBF1	0.36	0.33	enet	12	0.33	3.7e-26	-6.5	-6.5	7.1e-11	0.92	0.01	0.99	FALSE
8	GTEx	Brain Caudate basal ganglia	FBF1	0.35	0.20	enet	27	0.19	3.3e-06	-6.5	-6.1	9.6e-10	0.83	0.03	0.96	FALSE
9	GTEx	Brain Cortex	FBF1	0.34	0.25	lasso	3	0.25	1.5e-07	-5.4	-5.8	8.7e-09	0.79	0.07	0.92	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	FBF1	0.29	0.32	lasso	2	0.29	1.9e-08	-5.4	-5.4	7.4e-08	0.76	0.04	0.94	FALSE
11	GTEx	Breast Mammary Tissue	FBF1	0.15	0.20	lasso	3	0.19	6.9e-10	-6.5	-6.5	1.0e-10	0.89	0.02	0.98	FALSE
12	GTEx	Breast Mammary Tissue (Female)	FBF1	0.14	0.13	lasso	3	0.13	1.2e-04	-4.8	-5.3	1.2e-07	0.78	0.06	0.61	FALSE
13	GTEx	Cells Transformed fibroblasts	FBF1	0.14	0.08	lasso	5	0.07	5.1e-06	-6.5	-5.7	1.2e-08	0.79	0.02	0.97	FALSE
14	GTEx	Colon Sigmoid	FBF1	0.38	0.10	enet	19	0.17	1.5e-06	-6.8	-5.5	3.1e-08	0.87	0.00	1.00	FALSE
15	GTEx	Colon Transverse	TRIM65	0.32	0.13	lasso	6	0.12	3.1e-06	-6.5	-5.2	1.6e-07	0.83	0.00	1.00	FALSE
16	GTEx	Colon Transverse	FBF1	0.28	0.21	lasso	3	0.19	2.8e-09	-6.5	-6.4	1.3e-10	0.86	0.01	0.99	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	FBF1	0.33	0.16	lasso	6	0.13	2.3e-05	-5.4	-5.9	4.4e-09	0.84	0.01	0.98	FALSE
18	GTEx	Esophagus Muscularis	FBF1	0.34	0.33	lasso	3	0.32	5.5e-20	-6.5	-6.5	1.0e-10	0.88	0.01	0.99	FALSE
19	GTEx	Lung	UNC13D	0.12	0.09	enet	15	0.10	3.4e-08	-5.8	-5.6	1.8e-08	0.78	0.09	0.91	FALSE
20	GTEx	Lung	FBF1	0.20	0.18	lasso	1	0.17	2.6e-13	-6.5	-6.5	1.1e-10	0.88	0.01	0.99	FALSE
21	GTEx	Muscle Skeletal	FBF1	0.07	0.02	lasso	4	0.02	8.0e-03	-5.4	-5.6	2.0e-08	0.83	0.03	0.95	FALSE
22	GTEx	Nerve Tibial	FBF1	0.54	0.46	enet	37	0.45	2.9e-35	-6.5	-6.0	1.6e-09	0.86	0.01	0.99	FALSE
23	GTEx	Nerve Tibial	MRPL38	0.14	0.10	lasso	3	0.11	2.9e-08	-4.6	5.1	2.8e-07	-0.74	0.74	0.26	FALSE
24	GTEx	Nerve Tibial	RP11-552F3.9	0.14	0.05	lasso	5	0.07	2.0e-05	-6.2	5.2	2.2e-07	-0.72	0.02	0.95	FALSE
25	GTEx	Pituitary	FBF1	0.34	0.37	lasso	4	0.39	7.6e-11	-6.5	-6.2	5.3e-10	0.89	0.01	0.98	FALSE
26	GTEx	Prostate	FBF1	0.26	0.24	lasso	1	0.20	1.2e-05	-6.5	-6.5	1.1e-10	0.88	0.01	0.99	FALSE
27	GTEx	Skin Sun Exposed Lower leg	TRIM47	0.09	0.03	lasso	3	0.03	1.5e-03	-6.2	6.5	1.0e-10	-0.89	0.01	0.99	FALSE
28	GTEx	Skin Sun Exposed Lower leg	FBF1	0.22	0.23	lasso	1	0.21	3.0e-17	-6.5	-6.5	1.1e-10	0.88	0.01	0.99	FALSE
29	GTEx	Stomach	FBF1	0.28	0.17	enet	12	0.17	1.5e-08	-6.5	-6.5	6.4e-11	0.94	0.00	1.00	TRUE
30	GTEx	Testis	FBF1	0.37	0.38	lasso	2	0.38	8.4e-18	-6.5	-6.5	1.1e-10	0.88	0.01	0.99	FALSE
31	GTEx	Thyroid	WBP2	0.07	0.06	lasso	2	0.06	4.1e-05	-5.1	-5.5	4.0e-08	0.79	0.26	0.59	FALSE
32	GTEx	Thyroid	TRIM65	0.19	0.11	lasso	2	0.09	3.5e-07	-6.5	-6.1	8.9e-10	0.85	0.02	0.98	FALSE
33	GTEx	Thyroid	FBF1	0.24	0.23	lasso	2	0.23	8.0e-18	-6.5	-6.1	9.9e-10	0.87	0.01	0.99	FALSE
34	GTEx	Thyroid	MRPL38	0.15	0.07	lasso	3	0.09	1.1e-07	-4.9	5.4	6.7e-08	-0.74	0.44	0.56	FALSE
35	METSIM	Adipose	FBF1	0.20	0.09	enet	41	0.12	2.5e-17	-6.5	-5.3	9.3e-08	0.69	0.02	0.98	FALSE
36	METSIM	Adipose	TRIM65	0.13	0.03	enet	24	0.06	1.4e-09	-6.8	-5.8	5.0e-09	0.70	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	TRIM65	0.08	0.02	enet	7	0.04	1.9e-02	-4.7	-5.2	2.3e-07	0.72	0.02	0.48	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FBF1	0.08	0.05	blup	41	0.04	1.1e-02	-4.8	-5.8	8.4e-09	0.78	0.01	0.88	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM47	0.06	0.06	blup	30	0.06	1.6e-06	-6.1	5.1	2.9e-07	-0.69	0.14	0.86	FALSE