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chr17:60,858,059-62,599,864

Best TWAS P=3.11e-25 · Best GWAS P=7.14e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	ACE	0.16	0.14	lasso	6	0.13	5.1e-04	10.3	-10.4	3.1e-25	-0.95	0.00	0.88	TRUE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ACE	0.13	0.14	lasso	1	0.10	6.6e-05	10.3	-10.3	7.1e-25	-1.00	0.00	1.00	FALSE
5	GTEx	Colon Transverse	ACE	0.31	0.28	lasso	2	0.28	1.8e-13	10.3	-10.1	4.4e-24	-0.98	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACE	0.16	0.08	lasso	2	0.07	5.8e-05	8.5	-9.8	1.0e-22	-0.96	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	ACE	0.34	0.22	lasso	5	0.22	6.5e-13	8.5	-9.8	1.2e-22	-0.94	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACE	0.02	0.01	enet	3	0.01	1.3e-03	8.5	9.5	1.9e-21	0.93	0.00	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACE	0.08	0.05	lasso	4	0.04	1.0e-05	7.1	8.5	1.5e-17	0.82	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ACE	0.04	0.05	blup	52	0.04	9.4e-04	7.1	7.2	5.6e-13	0.66	0.01	0.88	FALSE
3	GTEx	Brain Putamen basal ganglia	DDX42	0.16	0.04	lasso	4	0.06	1.5e-02	4.8	7.2	5.8e-13	0.47	0.07	0.43	FALSE
26	The Cancer Genome Atlas	Stomach Adenocarcinoma	ACE	0.06	0.03	blup	53	0.02	9.3e-03	8.5	-6.6	3.4e-11	-0.72	0.02	0.95	FALSE
6	GTEx	Esophagus Mucosa	FTSJ3	0.19	0.24	lasso	7	0.21	6.0e-14	4.6	-6.5	7.0e-11	-0.34	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	CYB561	0.17	0.01	enet	6	0.08	2.0e-05	8.5	-6.3	2.2e-10	-0.58	0.01	0.44	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	KCNH6	0.03	0.01	blup	40	0.03	4.4e-04	4.9	-6.3	4.0e-10	-0.51	0.08	0.28	FALSE
2	GTEx	Brain Cerebellum	DDX42	0.12	0.00	enet	19	0.02	7.0e-02	4.6	6.1	1.1e-09	0.29	0.11	0.12	FALSE
7	GTEx	Esophagus Muscularis	FTSJ3	0.33	0.52	enet	57	0.54	8.2e-38	4.7	-6.1	1.3e-09	-0.27	1.00	0.00	FALSE
9	GTEx	Lung	ACE	0.18	0.07	lasso	8	0.07	3.9e-06	-5.7	-6.0	1.7e-09	-0.60	0.94	0.04	FALSE
8	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	-4.0	-5.9	3.2e-09	-0.23	0.44	0.17	FALSE
13	GTEx	Vagina	FTSJ3	0.30	0.48	lasso	2	0.50	2.7e-13	4.6	-5.5	3.8e-08	-0.29	0.98	0.01	FALSE
4	GTEx	Colon Transverse	FTSJ3	0.18	0.22	lasso	5	0.20	6.8e-10	4.7	-5.5	4.9e-08	-0.25	1.00	0.00	FALSE
10	GTEx	Lung	DDX42	0.06	0.04	enet	7	0.04	5.8e-04	4.7	5.3	1.4e-07	0.15	0.80	0.02	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	DDX42	0.06	0.04	blup	51	0.06	7.9e-08	4.7	5.2	1.6e-07	0.15	0.03	0.95	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	DDX42	0.04	0.01	blup	51	0.02	1.6e-02	4.5	5.2	1.8e-07	0.17	0.02	0.63	FALSE
14	METSIM	Adipose	SMARCD2	0.03	0.03	blup	321	0.02	1.8e-04	3.9	-5.2	1.9e-07	-0.12	0.92	0.00	FALSE
27	The Cancer Genome Atlas	Stomach Adenocarcinoma	DDX42	0.04	0.02	blup	51	0.04	5.2e-04	-4.0	5.2	2.1e-07	0.15	0.03	0.61	FALSE
11	GTEx	Muscle Skeletal	PSMC5	0.04	0.02	lasso	2	0.02	3.1e-03	-4.1	-5.2	2.2e-07	-0.13	0.49	0.03	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC5	0.13	0.06	blup	27	0.07	7.2e-05	4.5	-5.2	2.2e-07	-0.15	0.02	0.91	FALSE
12	GTEx	Skin Sun Exposed Lower leg	FTSJ3	0.23	0.38	enet	52	0.39	1.3e-34	4.5	-5.1	2.8e-07	-0.27	1.00	0.00	FALSE