TWAS hub - RAD50

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.133	0.0610	0.00630	0.008	NA	0.041	NA	0.039	1.2e-01	NA	3.5e-03	NA	4.1e-03
2	GTEx	Lung	0.120	0.0540	0.00280	0.087	NA	0.057	NA	0.079	3.7e-07	NA	3.5e-05	NA	1.3e-06
3	GTEx	Nerve Tibial	0.131	0.0459	0.00029	0.045	NA	0.053	NA	0.059	3.7e-04	NA	1.2e-04	NA	5.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Eosinophil Count	14.0	107.8	306.2	-1.3	17.5	-3.9
Crohns Disease (2012)	8.5	13.6	27.5	-3.2	-5.2	-1.8
Crohns Disease (2017)	8.1	17.7	36.7	-3.7	-6.1	-1.5
Blood Platelet Count	6.5	75.8	161.3	4.7	12.7	6.6
Mouth/teeth dental problems: Dentures	6.3	10.7	18.1	-2.7	-4.2	-2.6
Irritable Bowel Disease (IBD)	6.2	14.7	27.8	-3.8	-5.3	-1.5
Supplements: Calcium	5.1	5.6	9.8	-3.1	-1.9	-1.9
Asthma (self-reported)	4.7	9.3	26.8	-1.0	5.2	0.3
Cardiovascular Disease	4.4	14.7	30.1	2.2	5.5	3.0
Allergy	4.3	9.8	28.5	1.0	-5.3	-0.1
Asthma	4.3	8.4	24.4	-0.9	4.9	-0.0
Hayfever, allergic rhinitis or eczema	4.1	9.0	24.9	-1.0	5.0	1.0
LDL Cholesterol	3.9	6.1	7.8	2.2	2.4	2.8
Maternal smoking around birth	3.8	5.5	7.3	-2.7	-2.4	-1.9
Respiratory disease	3.6	8.0	20.3	-1.6	4.5	-1.0
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	7.0	-2.0	-2.6	-2.2
Hair/balding pattern: Pattern 3	3.1	4.6	7.6	-2.8	-1.0	-2.3
Illnesses of mother	3.0	3.7	7.3	-0.1	-2.7	-1.9
Happiness	2.9	3.5	9.0	3.0	1.0	0.8
Medication: Cholesterol lowering	2.9	4.6	5.1	2.2	2.1	2.1
Exposure to tobacco smoke at home	2.7	3.0	3.6	-1.7	-1.9	-1.7
Medication: Seretide 50 evohaler	2.6	3.0	7.3	-1.1	2.7	0.8
Ulcerative Colitis	2.5	3.6	5.0	-2.2	-2.2	-0.9
Commuting to job workplace: Walk	2.5	2.7	6.2	1.2	2.5	0.8
High cholesterol (Self-reported)	2.5	4.4	4.5	2.1	2.0	2.1
Medication: Co-codamol	2.4	2.8	4.6	-0.1	-2.0	-2.1
Risk taking	2.4	3.5	6.0	-2.4	-1.2	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	6.3	-1.2	-1.5	-2.5
Medication: Ventolin 100micrograms inhaler	2.2	2.9	8.4	0.3	2.9	0.4
Eye problems/disorders: Glaucoma	2.2	2.6	6.5	-0.0	-1.2	-2.5
Allergy or Eczema	2.1	5.5	15.7	-0.8	4.0	0.1
Multivitamins +/- minerals	2.1	2.7	3.9	-1.3	-2.0	-1.6
Time employed in main current job	2.1	2.4	4.2	-2.0	-1.1	-1.3
Average weekly beer plus cider intake	2.1	3.1	4.9	-1.9	-2.2	-0.8
Pack years of smoking	2.0	3.0	5.0	-1.9	-2.2	-0.6
Hand grip strength (right)	1.9	5.1	14.0	-0.7	-3.7	-0.9
Ulcerative Colitis (UC)	1.8	3.5	5.8	-2.0	-2.4	-0.7
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	5.0	-2.2	-0.8	-1.2
Ever had hysterectomy (womb removed)	1.8	2.0	3.1	-0.7	1.6	1.8
Pack years adult smoking proportion	1.8	2.8	4.3	-2.1	-2.0	-0.4
Hearing difficulty/problems with background noise	1.8	2.9	6.9	0.4	2.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.0	-1.7	-1.2	-1.6
Age started oral contraceptive pill	1.8	2.2	4.9	-1.1	-2.2	-0.7
Worry (Nagel 2018)	1.7	3.5	5.7	2.4	1.7	1.4
Breast Cancer	1.7	4.1	8.8	1.8	3.0	0.6
Prospective memory result	1.7	2.1	3.4	1.1	1.8	1.3
Glaucoma (self-reported)	1.7	2.0	4.6	0.2	-1.1	-2.2
Illnesses of father: High blood pressure	1.7	2.1	3.6	0.1	1.7	1.9
Unable to work because of sickness or disability	1.7	2.2	2.5	-1.6	-1.4	-1.5
Blood White Count	1.6	11.7	30.6	0.9	5.5	2.0
Birth weight	1.6	3.5	6.5	-1.4	-2.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	6.1	2.5	0.8	1.8
Friendships satisfaction	1.6	2.0	3.5	1.9	1.0	1.2
Mineral and other dietary supplements	1.6	2.1	6.0	2.4	0.1	0.7
Pain type(s) experienced in last month: Hip pain	1.6	2.1	3.0	-1.4	-1.7	-1.1
Neuroticism (Nagel 2018)	1.5	3.5	4.5	2.1	1.9	1.5
Alzheimer’s Disease (including proxy)	1.5	2.1	3.1	1.2	1.4	1.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	4.0	-0.2	-2.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	3.3	1.8	1.3	0.5
Breastfed as a baby	1.5	1.9	5.2	0.1	-2.3	-0.7
Medication: Blood pressure	1.5	2.9	5.5	-2.4	0.8	-1.6
Lung FEV1/FVC ratio	1.4	7.1	14.2	-1.9	-3.8	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	3.7	1.9	1.4	1.0
Medication: Blood pressure	1.4	2.5	4.0	1.4	2.0	1.3
Chest pain or discomfort	1.4	1.9	3.8	-1.4	-0.3	-1.9
Family relationship satisfaction	1.4	1.7	4.7	2.2	0.3	0.5
Smoking status: Current	1.4	2.2	3.9	-1.4	-2.0	-0.8
Number of self-reported non-cancer illnesses	1.4	2.4	3.8	-1.3	1.3	-2.0
Alcohol drinker status: Never	1.4	1.7	3.4	-1.9	-0.9	-1.0
Ever smoked	1.4	2.5	5.0	0.9	2.2	1.2
Hand grip strength (left)	1.3	3.4	10.1	0.1	-3.2	-0.3
Age when periods started (menarche)	1.3	3.1	7.8	-0.9	-2.8	-0.7
Heart disease (mother)	1.3	1.6	3.5	-0.9	0.5	1.9
Alzheimer’s Disease (in mother)	1.2	1.5	3.0	0.6	1.0	1.7
Sensitivity / hurt feelings	1.2	2.1	3.2	1.8	0.8	1.6
Supplements: Zinc	1.2	1.3	1.6	-1.1	-1.3	-1.0
Stomach or abdominal pain in last month	1.2	1.5	2.6	-1.3	-1.6	-0.5
Medication: Simvastatin	1.2	1.8	2.0	1.3	1.4	1.3
Father’s age at death	1.2	1.6	4.7	-0.0	-2.2	-0.4
Falls in the last year	1.2	1.7	2.5	-1.4	-0.8	-1.6
Comparative height size at age 10	1.2	6.7	14.9	-1.9	-3.9	-1.2
Financial situation satisfaction	1.2	1.5	2.2	1.5	0.8	1.3
Fractured/broken bones in last 5 years	1.2	1.5	2.9	-1.1	-1.7	-0.7
Lung FVC	1.1	5.6	13.3	1.5	3.6	1.2
Number of treatments/medications taken	1.1	2.0	5.8	-0.4	2.4	0.0
Current tobacco smoking	1.1	1.9	3.6	-1.2	-1.9	-0.7
Past tobacco smoking	1.1	2.0	4.7	-0.6	-2.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.4	1.5	0.7	1.1
High blood pressure (siblings)	1.1	1.6	3.6	-0.7	1.9	0.8
Pulse wave peak to peak time	1.1	1.4	2.1	-0.7	-1.5	-1.2
Eye problems/disorders: None of the above	1.1	1.3	2.8	0.5	0.9	1.7
Medication: Ibuprofen	1.1	1.3	1.9	1.4	0.9	1.1
Smoking status: Previous	1.1	1.7	4.5	0.6	2.1	0.5
Loneliness, isolation	1.1	1.5	3.4	0.3	1.8	1.0
Hearing aid user	1.1	1.3	2.5	0.6	1.6	1.0
Arm fat-free mass (left)	1.1	5.7	11.4	-0.6	-3.4	-2.3
Alzheimer’s Disease (in father)	1.0	1.1	1.8	0.8	1.4	0.9
Reaction Time	1.0	2.0	3.7	1.2	1.9	0.8
Body Mass Index (BMI) (2010)	1.0	1.3	2.0	-0.3	-1.4	-1.4
Height	1.0	19.2	57.1	0.3	-7.6	-0.8
Diabetes (mother)	1.0	1.3	3.0	0.2	1.7	1.0
Taking other prescription medications	1.0	1.5	2.4	-1.5	0.9	-1.2
High blood pressure	1.0	2.7	7.5	0.3	2.7	0.7
Pulse wave Arterial Stiffness index	1.0	1.1	1.5	0.7	1.2	1.2
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.3	1.5	0.7	1.8
Exposure to tobacco smoke outside home	1.0	1.3	2.0	-0.7	-1.2	-1.4
Medication: Aspirin	1.0	1.3	2.2	-1.2	-0.6	-1.5
Breast cancer (self-reported)	1.0	1.2	1.6	-1.0	-1.3	-0.9
Osteoarthritis (self-reported)	1.0	1.4	3.3	-0.9	0.1	-1.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.0	-2.0	0.2	0.0
Vascular/heart problems diagnosed by doctor	1.0	2.7	7.5	-0.3	-2.7	-0.7
Primary Biliary Cirrhosis	0.9	1.2	2.1	-0.7	-1.1	-1.4
Leg fat-free mass (left)	0.9	4.7	10.2	0.1	-3.2	-2.0
Leg predicted mass (left)	0.9	4.6	9.9	0.0	-3.1	-2.0
Emphysema/chronic bronchitis	0.9	1.1	1.6	-0.5	-1.2	-1.3
Had major operations	0.9	1.0	2.1	-1.5	0.1	-1.0
Supplements: Vitamin C	0.9	1.1	1.7	0.4	1.2	1.3
Long-standing illness, disability or infirmity	0.9	1.4	1.9	-1.4	1.2	-1.1
Ever had bowel cancer screening	0.9	1.0	2.5	-0.3	-1.6	-0.7
Medication: Gliclazide	0.9	1.0	1.8	-1.3	-0.3	-1.1
Arm fat mass (left)	0.9	3.6	7.1	-1.0	-1.7	-2.7
Basal metabolic rate	0.9	4.8	10.2	-0.0	-3.2	-2.1
Arm predicted mass (left)	0.9	4.5	9.1	-0.5	-3.0	-2.1
Ovarian Cancer	0.8	1.1	1.7	-1.3	-0.7	-1.1
Vitamin and mineral supplements	0.8	1.0	1.6	1.1	1.3	0.5
Illnesses of siblings	0.8	1.1	1.9	1.4	-1.2	-0.2
Weight	0.8	4.1	6.8	-0.2	-2.6	-2.4
Arm fat percentage (right)	0.8	3.3	7.8	-1.2	-0.9	-2.8
Number of live births	0.8	1.1	2.5	-0.7	-1.6	-0.5
Standing height	0.8	8.0	22.1	0.8	-4.7	-1.1
Pulse wave reflection index	0.8	1.0	2.4	0.6	1.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.2	0.8	1.5	0.6
Shortness of breath walking on level ground	0.8	1.0	1.7	-1.1	-0.5	-1.3
Whole body fat mass	0.8	3.3	6.4	-0.7	-1.7	-2.5
Whole body fat-free mass	0.8	4.7	10.2	0.0	-3.2	-1.9
Leg fat-free mass (right)	0.8	4.1	9.1	0.1	-3.0	-1.8
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	0.1	1.2	1.1
Medication for cholesterol	0.8	1.2	1.8	1.3	-0.9	1.0
Whole body water mass	0.8	4.8	10.6	-0.0	-3.3	-2.0
Leg predicted mass (right)	0.8	4.2	9.1	0.1	-3.0	-1.9
Number of operations (self-reported)	0.8	1.2	2.2	-1.1	-1.5	-0.6
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	0.8	1.7	0.7
Coronary Artery Disease (CAD)	0.7	0.9	2.2	0.6	0.3	1.5
Systolic Blood Pressure	0.7	3.4	7.2	0.5	2.7	1.6
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.3	1.0	1.2	0.6
Severe depression (siblings)	0.7	0.8	1.5	-1.2	-0.1	-1.0
Average weekly fortified wine intake	0.7	0.9	1.5	-0.3	1.2	1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.2	0.1	0.3	1.5
Serious illness, injury or assault to yourself	0.7	0.8	1.2	1.1	0.7	0.9
Trunk fat mass	0.7	2.8	5.2	-0.5	-1.7	-2.3
Nervous feelings	0.7	1.2	2.3	1.5	1.1	0.3
Diabetes (self-reported)	0.7	1.1	2.5	-0.8	-0.6	-1.6
Neuroticism score	0.7	1.4	3.2	1.8	1.0	0.3
Trunk fat-free mass	0.7	4.0	9.0	0.1	-3.0	-1.7
Worrier / anxious feelings	0.7	1.4	2.5	0.7	1.6	1.0
Depression (self-reported)	0.7	0.8	2.0	-1.4	0.2	-0.7
Arm fat mass (right)	0.7	3.0	5.9	-0.7	-1.6	-2.4
Trunk predicted mass	0.7	3.7	8.5	0.1	-2.9	-1.6
Migraine (self-reported)	0.7	0.8	1.1	1.1	1.1	0.5
Leg fat mass (right)	0.7	2.7	5.8	-1.0	-1.2	-2.4
Hypertension (Self-reported)	0.7	1.9	5.4	-0.1	2.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	0.3	1.2	0.9
Arm fat percentage (left)	0.7	3.0	6.8	-1.1	-0.9	-2.6
Qualifications: nursing, teaching	0.7	1.2	1.4	1.0	1.2	1.1
Back pain experienced in last month	0.7	1.0	1.6	-0.9	-0.9	-1.3
Basal cell carcinoma (self-reported)	0.7	0.8	2.2	-1.5	-0.5	-0.2
Fasting Glucose	0.6	0.7	1.1	-0.2	1.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	0.0	-0.9	-1.1
Medication: Levothyroxine sodium	0.6	1.0	2.0	0.9	0.4	1.4
Sitting height	0.6	4.4	11.7	0.1	-3.4	-1.2
Financial difficulties in last 2 years	0.6	0.9	1.2	0.7	1.1	0.9
Peak expiratory flow (PEF)	0.6	1.3	3.1	-0.5	-1.8	-0.7
Body fat percentage	0.6	2.3	5.4	-0.9	-0.9	-2.3
Leg fat percentage (right)	0.6	2.0	4.7	-1.2	-0.0	-2.2
Arm fat-free mass (right)	0.6	3.3	7.5	-0.1	-2.7	-1.6
Wheeze or whistling in the chest in last year	0.6	1.1	2.7	-0.8	0.1	-1.6
Number of children fathered	0.6	0.7	1.7	-1.3	-0.4	-0.3
Arm predicted mass (right)	0.6	2.9	6.7	-0.0	-2.6	-1.4
Suffer from ‘nerves’	0.6	0.9	2.4	1.6	0.0	-0.4
Medication: Aspirin	0.6	0.8	1.4	-0.7	-0.6	-1.2
Miserableness	0.6	1.0	1.7	1.3	1.2	-0.2
Guilty feelings	0.6	0.9	1.7	1.3	0.7	0.6
Ever taken oral contraceptive pill	0.6	0.7	1.6	1.3	-0.2	0.7
Diastolic blood pressure, automated reading	0.6	2.0	5.5	-0.2	2.4	0.6
Schizophrenia (2018)	0.5	1.1	2.7	1.6	-0.2	0.8
Major Depression (MDD)	0.5	0.6	0.7	-0.8	-0.8	-0.7
Bipolar Disorder (2011)	0.5	0.5	0.6	-0.6	-0.8	-0.7
Lupus	0.5	0.8	1.3	-1.2	0.4	0.9
Neuroticism (2016)	0.5	0.8	1.1	1.1	0.8	-0.8
Hypothyroidism (self reported)	0.5	1.1	1.6	1.3	-0.6	1.2
Medication: Metformin	0.5	0.7	1.7	-0.5	-0.0	-1.3
Trunk fat percentage	0.5	1.9	4.0	-0.7	-1.1	-2.0
Relative age voice broke	0.5	0.8	1.1	1.0	1.0	0.7
Hair/balding pattern: Pattern 2	0.5	0.7	1.5	0.5	0.5	1.2
Had other major operations	0.5	0.7	2.0	-1.4	0.1	-0.2
Mouth/teeth dental problems	0.5	0.7	1.2	0.6	1.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	-0.0	1.3	-0.4
Medication: Ramipril	0.5	0.6	1.7	-1.3	-0.0	-0.2
Tense / ‘highly strung’	0.5	0.9	2.4	1.6	-0.1	0.5
Hair/balding pattern: Pattern 4	0.5	1.2	1.4	-1.1	-1.2	-1.0
Blood clot in the leg (DVT)	0.5	0.6	1.1	-0.4	-1.0	-0.7
Worry too long after embarrassment	0.5	0.8	2.0	0.6	1.4	0.4
Age at last live birth	0.5	0.7	1.1	-0.8	-1.0	-0.5
Leg fat percentage (left)	0.5	2.0	4.5	-1.1	0.1	-2.1
Leg fat mass (left)	0.5	2.1	4.8	-0.7	-1.0	-2.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.1	1.5	0.7	0.7
Prostate Cancer	0.4	0.6	1.0	0.6	1.0	0.7
Mean Putamen Volume	0.4	0.4	1.0	-0.3	-0.4	-1.0
HDL Cholesterol	0.4	0.6	1.0	0.6	1.0	0.7
Schizophrenia (2014)	0.4	0.9	1.9	1.4	0.1	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	-1.0	-0.0	-0.5
Neuroticism	0.4	0.9	1.3	1.2	1.0	0.7
Chronotype (morning person)	0.4	0.8	1.2	0.6	0.9	1.1
Average weekly spirits intake	0.4	0.4	0.6	0.6	0.8	0.6
Waist circumference	0.4	1.4	3.1	-0.6	-0.8	-1.8
Alcohol intake versus 10 years previously	0.4	0.6	1.5	1.2	0.4	-0.5
Loud music exposure frequency	0.4	0.5	1.3	-0.2	0.2	-1.1
Comparative body size at age 10	0.4	1.1	2.6	-1.6	0.0	-0.9
Medication: Allopurinol	0.4	0.6	1.4	1.2	0.3	0.4
Number of full sisters	0.4	0.5	1.1	-0.6	-1.1	0.2
Overall health rating	0.4	0.8	1.9	-0.7	1.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	-0.4	-1.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.6	-0.8	-0.5	-0.8
Diabetes diagnosed by doctor	0.4	0.6	1.8	-0.4	-0.1	-1.3
Mother’s age at death	0.4	0.5	0.9	-1.0	0.4	-0.7
Medication: Bendroflumethiazide	0.4	0.7	1.8	0.1	1.3	-0.4
Medication: Lisinopril	0.4	0.5	1.0	0.1	0.7	-1.0
Medication: Atorvastatin	0.4	0.5	0.9	0.9	0.4	0.6
Bipolar Disorder (2018)	0.3	0.6	1.5	0.3	1.2	0.2
Age at First Birth	0.3	0.4	0.7	-0.4	-0.5	-0.8
HbA1C	0.3	0.3	0.7	-0.1	-0.8	-0.6
Smoking Status	0.3	0.8	1.4	-0.6	-0.8	-1.2
Medication for hormone replacement therapy	0.3	0.3	0.4	-0.4	0.6	0.6
Diabetes (father)	0.3	0.4	1.1	-0.0	-0.4	-1.0
Supplements: Glucosamine	0.3	0.4	0.7	-0.8	-0.4	-0.5
High blood pressure (mother)	0.3	0.4	0.8	-0.1	0.7	-0.9
Body mass index (BMI)	0.3	1.3	3.4	-0.5	-0.4	-1.9
Impedance of leg (left)	0.3	1.6	2.6	0.5	1.6	1.4
Number of incorrect matches in round	0.3	0.5	1.1	0.6	-0.0	1.1
Alcohol usually taken with meals	0.3	0.5	0.9	0.6	-0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.8	0.3	0.7
Had menopause	0.3	0.4	0.5	0.5	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	-0.4	1.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.1	1.1	-0.1
Hip circumference	0.3	1.3	3.6	0.1	-0.5	-1.9
Birth weight of first child	0.3	0.5	1.2	-1.1	-0.5	0.3
Headache pain in last month	0.3	0.5	0.6	0.7	0.6	0.8
Medication: Amlodipine	0.3	0.4	0.8	-0.6	0.9	0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	0.4	0.9	0.4
Health satisfaction	0.3	0.4	0.8	0.6	0.9	-0.3
Mean time to correctly identify matches	0.3	0.6	1.4	0.6	1.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	0.4	-0.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.8	-0.5	0.0
Osteoporosis (self-reported)	0.3	0.3	1.0	-1.0	0.2	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	0.9	-0.2	0.6
Wears glasses or contact lenses	0.3	0.3	0.4	-0.5	-0.6	-0.6
Irritability	0.3	0.5	0.7	0.8	0.6	0.5
Myopia	0.3	0.4	0.8	0.9	0.5	0.5
Pain experienced in last month	0.3	0.4	0.9	0.3	0.6	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	0.8	-0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.4	-0.8	-0.7
Depression (Nagel 2018)	0.2	0.2	0.5	0.7	0.2	0.4
Triglycerides	0.2	0.3	0.5	-0.3	-0.7	-0.6
Blood Red Count	0.2	2.1	3.1	0.4	1.7	1.8
BMI	0.2	1.2	2.9	-0.8	0.2	-1.7
Systolic blood pressure, automated reading	0.2	0.6	1.0	-0.8	1.0	0.5
Angina	0.2	0.2	0.5	-0.3	-0.7	-0.2
Impedance of leg (right)	0.2	1.1	1.8	0.3	1.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.6	0.6	0.8	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.4	-0.2	-0.7
Medication: Atenolol	0.2	0.3	0.4	0.5	0.5	-0.7
Forced vital capacity (FVC)	0.2	0.6	1.3	1.1	0.5	0.5
Heart attack	0.2	0.3	0.3	0.5	-0.5	-0.5
Noisy workplace	0.2	0.2	0.6	0.1	0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	0.1	1.0	0.3
Medication: Lansoprazole	0.2	0.2	0.6	-0.2	-0.0	0.7
Lung cancer (father)	0.2	0.3	0.7	-0.2	-0.9	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	0.6	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.3	0.8	-0.3
Medication: Paracetamol	0.2	0.3	0.5	0.7	0.1	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.9	0.0	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.3	0.5	0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	-0.4	-1.0	-0.3
Medication: Omeprazole	0.2	0.3	0.4	-0.5	0.3	-0.7
Pulse rate, automated reading	0.2	0.8	1.2	0.3	-1.1	-1.1
Leg pain on walking	0.2	0.2	0.5	0.1	-0.4	-0.7
Knee pain experienced in last month	0.2	0.3	0.5	0.7	-0.0	-0.7
Illnesses of siblings: Diabetes	0.2	0.3	0.4	-0.6	0.6	-0.1
Average weekly red wine intake	0.2	0.4	0.8	-0.9	0.6	0.0
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.3	1.0	0.3
Medication: Paracetamol	0.2	0.3	0.3	0.6	0.5	0.5
Ever depressed for a whole week	0.2	0.3	0.4	0.6	0.4	-0.6
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.1	-0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.4	0.5	-0.7
Heart disease (siblings)	0.2	0.2	0.3	-0.5	0.1	0.6
Alcohol drinker status: Previous	0.2	0.3	0.5	-0.6	-0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	-0.0	-0.2	-1.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.1	-0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	0.3	0.7	-0.5
Rheumatoid Arthritis	0.1	0.2	0.3	-0.6	0.1	-0.4
Heel T-Score	0.1	1.1	1.7	-1.3	0.6	1.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.2	0.7	-0.3
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.4	0.5	-0.2
Relative age of first facial hair	0.1	0.3	0.8	0.2	-0.3	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.1	-0.4	0.4
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.7	-0.3	0.2
Fed-up feelings	0.1	0.1	0.2	-0.4	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.1	0.1	0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.1	-0.2	0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	0.0	-0.1	-0.6
Qualifications: None of the above	0.1	0.2	0.5	0.0	0.7	0.3
Pain all over the body in last month	0.1	0.1	0.3	0.5	0.1	0.0
Fluid intelligence score	0.1	0.3	0.7	0.4	0.9	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.7	-0.1	0.4
Pulse rate	0.1	0.2	0.4	0.2	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.6	0.2	0.6
Impedance of arm (left)	0.1	0.3	0.7	0.3	-0.1	0.8
Length of working week for main job	0.1	0.1	0.2	-0.3	-0.5	-0.1
Gout (self-reported)	0.1	0.1	0.2	0.4	0.1	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.3	0.4	0.6	0.6	0.5
Number of full brothers	0.1	0.2	0.4	-0.4	-0.6	0.1
Age at first live birth	0.1	0.2	0.2	-0.5	-0.2	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.1	0.2	0.3	0.3
Angina (self-reported)	0.1	0.2	0.5	-0.0	-0.7	-0.2
Alcohol intake frequency.	0.1	0.3	0.7	0.5	0.8	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.0	-0.3	-0.4
Mood swings	0.1	0.1	0.3	-0.2	0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.5	0.5	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.3	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.2	0.1	-0.4
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.3	0.4	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.1	-0.6	0.0
Cholesterol lowering medication	0.1	0.2	0.4	-0.6	-0.2	-0.3
Impedance of whole body	0.1	0.6	1.3	0.4	0.5	1.2
Waist Hip Ratio (WHR)	0.0	0.2	0.5	-0.7	-0.1	0.2
Hair Pigment	0.0	0.1	0.3	0.4	0.2	0.5
Tanning	0.0	0.4	0.7	-0.9	-0.6	-0.3
Impedance of arm (right)	0.0	0.1	0.3	0.1	-0.1	0.5
Qualifications: College or University degree	0.0	0.0	0.1	-0.1	0.2	-0.1
Illnesses of father: Heart disease	0.0	0.1	0.1	-0.2	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.2	0.0	0.1

Hub : Genes

RAD50

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Trait associations