Hub : Genes

C5orf56

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0270	0.0130	0.00450	0.009	0.009	0.009	0.007	0.012	2.7e-02	0.02300	0.0240	0.0420	0.0100
2	NTR	Blood	0.0150	0.0072	0.00660	0.006	0.007	0.004	0.006	0.007	4.6e-03	0.00170	0.0170	0.0029	0.0019
3	TCGA	Brain Lower Grade Glioma	0.0344	0.0203	0.00430	0.013	0.017	0.011	NA	0.012	1.1e-02	0.00410	0.0160	NA	0.0150
4	TCGA	Lung Squamous Cell Carcinoma	0.0656	0.0341	0.00030	0.005	0.028	0.020	NA	0.016	7.2e-02	0.00032	0.0022	NA	0.0053
5	TCGA	Prostate Adenocarcinoma	0.0821	0.0447	0.00042	0.032	0.022	0.022	NA	0.030	2.7e-04	0.00220	0.0020	NA	0.0004
6	TCGA	Thyroid Carcinoma	0.0630	0.0290	0.00005	0.043	0.026	0.019	NA	0.025	4.3e-05	0.00130	0.0055	NA	0.0016

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.3	3.3	-1.3	1.3	-1.8	-0.3	-0.5	-0.8
Bipolar Disorder or Schizophrenia	0.6	1.5	6.4	-0.0	2.5	-0.5	-0.4	0.6	-1.3
Depressed Affect (Nagel 2018)	0.6	1.2	4.0	0.5	-0.7	-2.0	-0.4	-1.6	-0.0
Depression (Nagel 2018)	0.4	0.5	1.4	1.2	-0.3	0.1	0.6	-0.3	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.0	-1.1	-1.4	-0.8	0.2	-0.2	0.4
Neuroticism (Nagel 2018)	0.7	1.7	4.1	1.7	0.4	-1.8	-0.4	-2.0	0.1
Schizophrenia (2018)	0.7	1.5	4.6	1.0	2.2	0.8	-0.3	1.1	-1.1
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	0.8	0.3	1.0	-0.3	0.9	-1.3
Worry (Nagel 2018)	0.8	1.7	3.0	1.7	1.7	-1.3	-0.3	-1.5	-0.3
Alzheimer’s Disease (in mother)	1.6	1.9	4.6	1.9	2.1	0.2	-0.5	0.7	-1.5
Alzheimer’s Disease (in father)	0.8	0.9	1.9	0.3	0.2	-1.4	-1.3	-0.9	-0.7
Alzheimer’s Disease (including proxy)	1.1	1.6	4.4	1.8	2.1	-0.5	-0.6	0.2	-1.3
Crohns Disease (2017)	19.9	43.7	92.4	2.8	-9.0	9.6	5.4	3.4	6.4
Irritable Bowel Disease (IBD)	14.3	34.0	70.4	1.9	-8.3	8.4	4.8	3.0	5.4
Ulcerative Colitis (UC)	3.9	7.3	15.5	0.6	-3.9	3.8	2.3	1.4	2.4
Major Depression (MDD)	0.4	0.5	0.9	-0.6	-0.8	0.9	0.9	0.5	0.6
Reaction Time	1.3	2.5	7.1	-0.6	1.5	-2.7	-1.0	-2.0	-0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-0.6	-0.7	-1.4	-0.7	-1.1	-0.4
Breast Cancer	4.4	10.7	20.1	-1.9	4.5	-4.1	-2.8	-0.4	-4.0
Ovarian Cancer	0.7	0.9	2.8	-1.7	-1.4	0.1	-0.4	0.7	-0.0
Prostate Cancer	0.6	0.8	1.5	1.2	0.5	-1.1	-0.4	-1.2	-0.0
Age at First Birth	0.2	0.3	1.2	-1.1	0.1	0.0	0.8	0.4	0.2
Bipolar Disorder (2011)	0.6	0.5	1.8	-0.5	-0.2	0.6	1.4	-0.1	0.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.6	-1.2	-0.1	0.7	0.5	0.5	0.7
Coronary Artery Disease (CAD)	2.0	2.4	4.4	1.5	1.6	1.3	-0.7	1.8	-2.1
Crohns Disease (2012)	18.1	29.2	59.8	1.6	-7.6	7.7	4.3	2.8	5.4
Mean Putamen Volume	0.5	0.6	1.5	-0.6	-0.7	0.0	1.1	-0.3	1.2
Fasting Glucose	0.6	0.8	2.4	0.6	-0.5	-1.0	-0.8	-1.6	0.1
HbA1C	0.2	0.3	0.6	-0.0	-0.5	0.8	0.6	0.5	0.2
HDL Cholesterol	0.6	1.0	2.1	1.1	0.5	-1.3	0.5	-1.4	0.9
LDL Cholesterol	1.9	3.0	7.3	2.7	0.4	-1.3	-2.3	-1.6	-1.2
Lupus	0.7	1.0	3.4	1.8	-1.1	0.8	0.7	-0.1	0.4
Neuroticism (2016)	0.6	0.8	2.7	-0.9	-0.0	-1.6	0.4	-1.0	0.3
Primary Biliary Cirrhosis	0.4	0.5	1.5	-1.2	-0.7	0.1	0.6	-0.1	0.9
Rheumatoid Arthritis	0.2	0.3	0.9	0.2	0.9	-0.4	0.5	-0.6	-0.3
Schizophrenia (2014)	0.5	1.1	3.9	0.7	2.0	0.4	-0.3	0.8	-1.2
Triglycerides	0.8	1.4	4.1	-1.4	-0.4	0.1	-1.4	0.3	-2.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.3	0.1	0.3	0.1	-0.2	-0.4
Ulcerative Colitis	4.1	5.9	17.0	0.3	-4.1	3.6	1.6	1.0	1.6
Blood Eosinophil Count	53.6	412.8	829.4	-20.6	13.2	-28.8	-16.9	-15.0	-23.2
Blood Platelet Count	11.0	128.0	278.9	-3.6	7.6	-13.7	-14.0	-6.0	-16.7
Blood Red Count	0.2	1.9	4.3	0.5	1.9	-1.3	-1.1	-0.5	-2.1
Blood White Count	7.6	56.4	163.8	-5.8	6.6	-6.5	-7.4	0.8	-12.8
Heel T-Score	0.2	1.8	7.0	0.1	0.1	0.5	-0.7	1.8	-2.6
BMI	0.5	2.7	10.0	-3.2	-1.3	-1.9	-0.7	-0.7	-0.3
Height	6.2	118.9	306.1	8.3	-8.1	10.7	12.2	3.3	17.5
Waist Hip Ratio (WHR)	0.3	1.3	4.1	2.0	-0.8	1.4	0.8	-0.5	0.5
Systolic Blood Pressure	0.9	4.5	16.0	-0.0	1.6	-1.5	-2.4	-0.6	-4.0
Smoking Status	0.6	1.4	6.8	-0.8	-2.6	0.3	0.1	-0.0	1.0
Allergy or Eczema	4.0	10.7	24.9	-2.0	2.1	-4.3	-2.5	-2.4	-5.0
Cardiovascular Disease	5.3	17.5	32.9	-1.0	3.3	-5.7	-4.7	-2.8	-5.4
Hypothyroidism (self reported)	0.9	2.0	5.4	2.3	-0.5	2.3	0.8	0.2	0.7
Respiratory disease	10.2	22.8	52.0	-4.0	5.5	-5.7	-2.4	-0.7	-7.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.8	-1.7	0.2	-0.6	-0.3	0.9	-1.3
Lung FEV1/FVC ratio	5.5	28.0	106.1	0.8	-10.3	4.0	1.9	-2.3	6.0
Lung FVC	3.7	19.0	32.8	-2.5	5.5	-5.7	-3.6	-3.7	-4.2
Neuroticism	0.2	0.5	1.6	0.8	-0.5	-0.8	0.0	-1.3	0.1
Chronotype (morning person)	0.4	0.9	1.5	0.5	1.2	-0.6	-1.0	0.8	-1.2
Hair Pigment	0.0	0.6	3.1	0.4	1.8	-0.7	-0.2	-0.2	-0.3
Tanning	0.0	0.6	1.4	-0.2	0.8	0.6	0.9	1.2	0.6
Hand grip strength (left)	6.1	16.0	41.2	3.1	-2.9	4.2	4.2	1.1	6.4
Number of treatments/medications taken	3.5	6.2	12.5	-1.4	2.0	-3.1	-2.4	-1.9	-3.5
Average weekly spirits intake	0.3	0.4	1.2	0.6	1.1	-0.4	-0.2	0.4	-0.4
Sensitivity / hurt feelings	0.7	1.3	3.3	1.8	-1.8	0.1	-0.6	-0.8	0.1
Frequency of depressed mood in last 2 weeks	1.0	1.5	3.3	0.9	-1.8	-1.0	-0.6	-1.7	0.6
Hearing difficulty/problems: Yes	0.3	0.5	2.0	-0.2	1.4	-0.6	0.0	-0.5	-0.2
Relative age of first facial hair	0.6	1.3	4.3	-0.5	2.1	-0.2	0.1	1.6	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.1	-1.4	-0.7	0.6	0.6	0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.3	0.9	0.8	1.1	0.8	0.6	-0.1
Ever had hysterectomy (womb removed)	1.6	1.8	3.4	0.9	-0.6	-1.4	-1.5	-1.8	-1.3
Systolic blood pressure, automated reading	0.3	1.0	4.5	-0.3	0.1	0.3	-0.7	0.8	-2.1
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	5.4	-1.1	-2.3	0.8	0.8	0.8	1.0
Angina	0.5	0.7	2.9	-0.3	0.4	0.8	0.0	1.7	-0.5
Medication for hormone replacement therapy	0.5	0.5	1.9	-0.3	-0.1	-0.3	-1.1	0.1	-1.4
Vitamin and mineral supplements	0.9	1.2	2.3	-0.5	1.3	-1.5	-1.2	-0.5	-1.1
Supplements: Zinc	1.1	1.2	2.9	-0.1	-1.6	0.8	1.0	-0.4	1.7
Medication: Co-codamol	2.7	3.1	7.4	-1.9	-1.2	1.9	1.5	2.7	0.6
Medication: Metformin	1.0	1.4	6.9	-2.6	-0.3	-0.8	-0.4	0.3	-0.9
Diabetes (father)	0.3	0.4	0.9	-1.0	-0.9	0.2	-0.2	0.5	-0.5
Diabetes (mother)	1.9	2.4	4.2	-0.1	0.8	-1.6	-2.0	-1.9	-1.9
Severe depression (siblings)	0.2	0.2	1.0	-1.0	-0.3	-0.1	0.3	-0.3	-0.2
Pack years adult smoking proportion	2.2	3.4	9.5	1.2	-0.9	3.1	2.0	1.7	1.3
Impedance of leg (right)	0.5	2.3	7.8	0.6	2.0	-0.4	-1.4	0.1	-2.8
Leg fat-free mass (left)	3.9	20.9	66.9	1.3	-4.8	2.9	5.0	0.0	8.2
Trunk fat percentage	0.5	1.8	5.5	-2.3	-1.6	0.2	1.1	0.1	1.3
Hand grip strength (right)	6.9	18.7	43.8	2.9	-4.0	4.8	4.5	0.8	6.6
Townsend deprivation index at recruitment	0.0	0.1	0.2	0.2	0.4	0.4	0.2	0.0	-0.2
Current tobacco smoking	1.2	1.9	4.2	0.4	-1.7	2.0	1.3	0.9	1.4
Average weekly fortified wine intake	0.9	1.1	3.2	0.9	1.0	-1.2	-0.0	-1.8	0.0
Maternal smoking around birth	2.4	3.5	6.4	-0.4	-1.1	2.4	2.5	1.8	2.0
Fed-up feelings	0.4	0.8	3.1	0.4	-1.8	-0.3	0.4	-0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	1.5	-0.2	0.4	0.8	-0.4	0.8
Relative age voice broke	0.9	1.4	5.4	0.4	2.3	-1.1	-0.9	-0.0	-1.0
Taking other prescription medications	1.5	2.3	7.1	-2.0	0.3	-1.2	-0.6	-0.7	-2.7
Age when periods started (menarche)	2.8	6.7	11.3	1.4	-3.0	3.3	2.5	0.4	3.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.9	1.4	-0.8	0.5	-0.6	-0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	0.3	-0.0	-0.1	-0.2	0.4	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.1	-0.4	0.1	0.1	-0.2	0.5
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.9	-0.1	0.7	0.2	1.0	0.5
Serious illness, injury or assault to yourself	0.2	0.3	1.1	1.0	0.7	0.1	-0.2	0.1	0.1
High blood pressure	3.5	9.8	20.8	-3.0	2.4	-3.4	-3.3	-0.7	-4.6
Hayfever, allergic rhinitis or eczema	7.5	16.3	32.8	-1.4	2.9	-5.5	-3.6	-3.5	-5.7
Multivitamins +/- minerals	1.5	1.9	3.0	-0.4	-1.7	1.7	1.6	0.9	1.4
Stomach or abdominal pain in last month	2.4	3.0	5.6	1.3	-1.1	2.3	2.0	0.7	2.4
Supplements: Glucosamine	0.2	0.2	0.4	-0.2	-0.6	0.3	0.6	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.3	-0.2	0.4	1.7	2.1	2.0	1.7
Medication: Atenolol	1.6	2.0	5.3	-2.3	0.9	-1.1	-0.9	0.8	-1.8
Medication: Levothyroxine sodium	0.5	0.9	3.7	1.9	-0.4	0.8	-0.2	-0.7	0.3
Sitting height	3.6	25.5	74.5	3.2	-4.5	4.0	5.7	-0.1	8.6
Chronic bronchitis/emphysema (father)	0.5	0.5	1.4	-1.0	0.8	-0.1	-0.4	0.3	-1.2
High blood pressure (mother)	1.3	1.8	4.6	-2.2	1.5	-1.2	-0.8	0.5	-1.3
Body mass index (BMI)	0.4	1.6	8.1	-2.9	-0.4	-1.0	0.1	0.1	0.2
Impedance of leg (left)	0.8	4.1	13.1	0.1	2.6	-1.0	-1.9	0.1	-3.6
Leg predicted mass (left)	3.9	20.8	66.3	1.2	-4.8	2.9	5.0	-0.1	8.1
Trunk fat mass	1.1	4.7	11.9	-1.6	-2.8	0.9	2.3	0.0	3.5
Waist circumference	0.5	2.0	4.3	-1.4	-2.1	0.3	1.3	-0.2	2.0
Number of incorrect matches in round	0.3	0.5	1.4	0.9	0.3	1.2	-0.2	0.5	-0.3
Past tobacco smoking	1.5	2.8	5.9	1.0	-0.1	2.1	2.4	0.0	2.3
Alcohol usually taken with meals	0.4	0.6	2.4	-1.5	-0.4	-0.5	0.4	0.1	0.7
Nervous feelings	0.5	1.0	2.6	-0.1	1.6	-1.4	-0.6	-0.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.7	1.6	-0.4	0.5	0.7	-0.1	1.2
Hearing difficulty/problems with background noise	2.7	4.2	8.2	0.1	1.5	-2.7	-1.9	-2.9	-2.0
Hair/balding pattern: Pattern 2	1.3	1.6	6.6	2.6	1.3	0.7	0.7	0.6	0.5
Had menopause	0.6	0.8	2.5	-0.2	1.6	-0.2	-0.2	1.3	-0.8
Had other major operations	0.7	0.9	3.8	0.6	-0.6	0.1	0.4	-2.0	0.7
Forced vital capacity (FVC)	0.5	1.8	5.9	1.0	0.6	-0.7	1.0	-1.4	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	2.0	0.2	-0.5	-0.0	-0.6	0.0	-1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	-0.6	-0.3	-1.0	-0.8	-1.1	-0.8
Qualifications: None of the above	0.3	0.5	2.0	-0.2	-0.8	-0.2	-0.6	-0.5	-1.4
Financial difficulties in last 2 years	0.4	0.6	1.1	0.8	-0.9	-0.8	-0.7	-1.0	0.1
Mouth/teeth dental problems	0.6	0.9	2.9	-0.1	1.0	-1.7	-1.0	-0.9	-0.3
Heart attack	1.4	1.7	5.3	-0.9	2.3	0.5	-0.1	1.8	-1.0
Allergy	10.4	23.8	50.4	2.9	-4.7	6.5	3.7	2.5	7.1
Pain all over the body in last month	0.7	0.7	3.0	0.7	-1.7	0.3	-0.8	-0.4	-0.2
Diabetes (self-reported)	0.9	1.4	6.6	-2.6	-0.6	0.1	0.8	1.1	-0.0
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.0	-0.7	1.0	-2.0	-0.7	-1.6	-1.6
Medication: Ramipril	0.6	0.8	2.9	-0.8	0.8	0.3	-0.7	0.2	-1.7
Medication: Simvastatin	0.6	0.9	2.5	0.8	1.6	-0.9	-0.7	-0.7	-0.8
Fluid intelligence score	0.3	0.7	1.3	-0.1	-0.5	-1.1	-0.9	-1.0	-0.8
Illnesses of siblings	1.6	2.3	7.2	0.3	-2.1	1.0	0.8	0.6	2.7
Neuroticism score	0.2	0.5	1.3	0.3	-0.7	-1.1	0.1	-1.0	0.2
Weight	2.3	11.4	35.6	-0.4	-3.7	2.0	3.9	0.3	6.0
Impedance of arm (right)	0.1	0.6	1.1	0.8	-1.0	1.0	-0.5	-0.5	-0.4
Arm fat percentage (right)	0.7	2.9	14.0	-3.7	-1.4	-0.8	0.3	-0.4	0.5
Trunk fat-free mass	3.6	20.9	67.2	1.9	-4.6	2.9	5.1	0.0	8.2
Hip circumference	0.5	2.1	4.8	-2.2	-1.4	-0.7	1.1	-0.5	2.0
Time employed in main current job	0.7	0.8	2.8	-1.1	-1.7	0.4	0.1	-0.1	0.6
Alcohol intake versus 10 years previously	0.8	1.1	2.8	-0.7	1.6	-1.7	0.1	-0.8	0.4
Father’s age at death	4.2	5.7	10.1	1.0	-2.0	3.2	2.4	2.0	3.0
Worrier / anxious feelings	0.7	1.4	2.5	-0.1	-1.4	-1.6	-1.2	-1.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.6	1.5	-0.1	-1.1	-0.6	-2.1	0.4
Falls in the last year	0.6	0.9	2.0	-1.4	-0.9	0.6	1.3	-0.2	0.6
Hair/balding pattern: Pattern 3	2.1	3.2	10.6	-3.2	-2.5	-1.0	-0.5	-1.1	-0.2
Number of live births	2.1	2.9	8.2	-0.4	-1.1	2.4	1.3	2.9	0.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	10.9	1.2	-2.1	0.1	1.1	-2.0	3.3
Pulse rate	0.3	0.5	0.9	-0.6	-0.9	0.6	0.5	0.9	0.6
Happiness	0.7	0.9	2.5	1.6	0.0	-0.8	0.3	-1.1	0.9
Noisy workplace	1.4	1.7	7.5	-0.2	2.7	-1.4	-0.6	0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.4	-0.5	0.9	-2.1	-0.5	-0.7	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	0.4	-0.9	-1.1	-0.8	-0.4	0.1
Mouth/teeth dental problems: Dentures	5.9	10.0	20.1	-0.8	-1.2	4.5	3.7	4.4	2.2
Asthma	12.2	24.1	63.7	-2.9	5.3	-5.7	-3.3	-1.0	-8.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	1.3	0.9	-0.2	0.1	-0.6	-0.1
Medication: Cholesterol lowering	2.5	3.9	6.6	1.2	2.6	-1.7	-2.5	-0.6	-2.5
Depression (self-reported)	0.2	0.2	1.0	-0.4	-0.1	-0.2	0.1	-1.0	-0.3
Medication: Lansoprazole	0.6	0.7	2.0	1.4	0.9	1.0	0.3	0.7	0.2
Prospective memory result	1.6	1.9	3.9	-0.3	1.8	-1.2	-1.6	-0.2	-2.0
Lung cancer (father)	1.1	1.3	2.8	1.3	-1.4	1.7	0.3	0.8	0.8
Illnesses of mother	3.3	4.1	12.1	-0.2	-2.0	1.8	2.3	0.2	3.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	10.2	1.0	-2.2	-0.4	0.8	-3.2	3.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	1.0	-0.6	-0.1	-0.7	-0.8	-1.0
Impedance of arm (left)	0.2	0.7	1.8	1.3	-0.8	1.2	-0.2	-0.4	-0.2
Arm fat mass (right)	0.9	3.6	8.8	-2.1	-2.2	0.5	1.9	-0.1	3.0
Trunk predicted mass	3.6	20.4	65.6	1.9	-4.5	2.8	5.0	-0.0	8.1
Standing height	5.8	57.2	158.0	5.3	-7.1	6.4	8.2	0.5	12.6
Length of working week for main job	0.3	0.3	0.8	0.3	0.9	0.3	0.6	0.7	0.6
Exposure to tobacco smoke at home	2.2	2.5	4.6	-1.4	-0.7	1.5	2.1	1.6	1.8
Breastfed as a baby	1.8	2.2	7.6	0.3	-0.9	1.6	1.2	0.9	2.8
Tense / ‘highly strung’	0.9	1.5	2.9	1.7	1.6	0.3	1.4	0.3	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	4.7	-1.4	-1.2	0.6	2.1	-0.3	2.2
Hair/balding pattern: Pattern 4	0.3	0.8	3.6	-1.9	0.1	1.0	0.1	0.3	-0.2
Birth weight of first child	1.1	2.1	5.2	1.7	-1.4	0.5	1.1	-1.1	2.3
Peak expiratory flow (PEF)	2.4	5.5	15.3	0.7	-2.8	1.8	2.5	-0.0	3.9
Pulse wave reflection index	1.7	2.1	3.6	-0.8	0.8	-1.7	-1.4	-1.9	-1.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.1	0.6	0.1	0.7	0.5	1.0
Loud music exposure frequency	0.6	0.7	2.1	-1.5	0.6	-1.0	0.6	0.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	-0.0	0.2	-1.4	0.2	-1.4	1.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	4.5	-0.5	-0.0	-1.4	-1.7	-1.3	-2.1
Blood clot in the leg (DVT)	0.6	0.8	1.5	0.3	-1.0	1.1	0.7	0.6	1.2
Medication: Paracetamol	0.6	0.9	2.9	1.2	-0.8	-0.3	0.1	-0.7	1.7
Headache pain in last month	0.6	1.1	2.9	1.3	1.7	-0.2	0.5	-1.0	0.7
Medication for cholesterol, blood pressure or diabetes	3.9	6.5	13.9	-0.6	-2.8	2.2	3.4	0.5	3.7
Glaucoma (self-reported)	1.6	1.9	5.3	-2.3	1.2	-0.5	1.2	1.2	1.2
Gout (self-reported)	1.1	1.5	4.1	-0.0	1.3	-1.1	1.3	-0.6	2.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	6.1	2.5	-0.3	0.7	-0.1	-0.9	0.3
Medication: Amlodipine	1.4	2.0	4.3	-1.5	2.1	-1.2	-0.7	0.5	-1.8
Medication: Ventolin 100micrograms inhaler	3.9	5.1	12.0	-0.8	2.0	-3.0	-1.9	-0.9	-3.5
Birth weight	2.6	5.6	10.3	0.5	-3.2	2.6	2.4	0.7	3.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.9	0.5	2.0	-0.7	-0.6	-0.3	-1.6
High blood pressure (siblings)	2.6	3.7	12.1	-0.3	1.9	-1.6	-1.8	-0.7	-3.5
Forced vital capacity (FVC), Best measure	0.6	2.3	5.9	0.7	0.4	-1.2	0.9	-2.4	2.3
Body fat percentage	0.5	2.0	9.9	-3.1	-1.2	-0.4	0.7	0.1	0.6
Leg fat percentage (right)	0.8	3.0	13.8	-3.7	0.1	-1.7	-0.4	-0.0	-1.0
Arm fat-free mass (right)	3.2	16.2	50.8	1.4	-4.0	2.6	4.7	0.4	7.1
Exposure to tobacco smoke outside home	2.6	3.5	8.0	0.1	-2.5	1.1	2.2	-0.6	2.8
Comparative body size at age 10	0.3	0.9	3.4	-1.8	0.2	-1.1	-0.4	-0.5	-0.8
Number of full brothers	0.6	0.7	2.6	1.2	-0.4	1.6	-0.1	0.0	0.1
Worry too long after embarrassment	0.6	1.0	3.1	0.2	-0.1	-1.8	-0.2	-1.6	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.8	-0.6	-2.4	1.3	1.0	-0.7	1.1
Wheeze or whistling in the chest in last year	1.1	2.0	4.1	-2.0	2.0	-0.9	0.6	1.1	-1.2
Number of children fathered	0.3	0.4	1.1	0.5	-1.0	0.9	0.3	-0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.8	-1.0	1.7	-0.5	-0.9	1.1	-1.0
Age at first live birth	0.1	0.1	0.5	-0.2	0.7	-0.1	0.4	0.1	-0.3
Pulse wave peak to peak time	0.8	0.9	3.0	-0.6	0.2	0.4	1.2	0.7	1.7
Health satisfaction	0.4	0.6	1.0	-0.8	0.5	-1.0	-0.7	0.4	-1.0
Shortness of breath walking on level ground	0.5	0.6	2.8	-1.7	-0.0	-0.5	0.5	0.5	0.0
Qualifications: College or University degree	0.1	0.5	1.3	-0.8	0.3	-1.1	-0.6	-0.6	-0.1
Eye problems/disorders: None of the above	1.0	1.1	4.7	2.2	1.1	-0.0	0.2	-0.8	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.1	-0.4	0.2	-0.2	-0.2	-0.6
Emphysema/chronic bronchitis	1.2	1.3	2.1	-1.1	-0.5	0.9	1.4	1.5	1.2
Medication for pain relief, constipation, heartburn	0.5	0.9	2.6	-0.1	-0.7	1.6	0.2	1.6	0.2
Neck or shoulder pain in last month	0.9	1.2	4.1	0.7	2.0	-0.5	1.5	0.0	0.7
Medication: Blood pressure	3.2	5.6	13.3	-0.5	2.6	-1.9	-3.2	0.3	-3.6
Angina (self-reported)	0.6	0.7	3.2	-0.3	0.2	0.8	-0.2	1.8	-0.7
Migraine (self-reported)	0.8	1.0	2.5	0.6	1.0	-1.3	-0.6	-1.6	0.0
Medication: Ibuprofen	0.5	0.5	1.4	1.2	1.1	-0.2	-0.1	-0.6	-0.5
Medication: Allopurinol	0.7	0.9	2.1	0.6	1.5	-0.9	0.6	-0.6	1.2
Medication: Omeprazole	0.6	0.7	1.6	-1.3	-0.1	-1.0	0.1	-0.9	-0.7
Medication: Seretide 50 evohaler	6.2	7.2	23.7	-0.9	2.5	-2.6	-2.3	-0.5	-4.9
Mean time to correctly identify matches	0.9	1.7	4.6	-1.3	1.3	-2.2	-0.8	-1.1	-0.6
Heart disease (mother)	0.7	0.9	2.5	1.6	-0.1	0.7	-0.8	0.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.9	1.3	-1.4	1.7	0.3	1.5	0.5
Whole body fat mass	1.0	4.3	9.9	-2.1	-2.5	0.6	2.2	0.0	3.1
Leg fat mass (right)	0.7	2.7	6.6	-2.6	-1.6	-0.2	1.5	0.1	2.1
Arm predicted mass (right)	3.0	15.4	48.5	1.5	-3.4	2.6	4.8	0.7	7.0
Pulse rate, automated reading	0.1	0.4	2.1	-1.4	-0.2	-0.0	-0.1	0.1	-0.1
Alcohol intake frequency.	0.4	0.8	2.4	-0.5	1.6	-1.3	0.3	-0.7	-0.1
Comparative height size at age 10	5.8	31.8	75.2	3.8	-5.9	5.5	6.0	0.5	8.7
Number of full sisters	1.1	1.3	2.0	1.2	-0.9	1.4	1.3	0.6	1.4
Suffer from ‘nerves’	0.6	0.9	1.9	0.6	1.1	-0.4	1.2	-0.5	1.4
Overall health rating	0.6	1.2	3.1	-0.5	-0.7	-1.3	-0.3	-1.8	-1.2
Chest pain or discomfort	0.9	1.3	5.9	-2.4	-1.0	-0.5	0.4	-0.4	0.2
Had major operations	0.6	0.7	2.7	-1.6	-1.0	-0.3	0.2	-0.1	-0.7
Age at last live birth	0.4	0.6	1.4	0.0	0.3	1.2	1.0	1.1	0.3
Family relationship satisfaction	0.5	0.6	2.0	1.4	-0.2	0.7	0.5	0.2	0.8
Leg pain on walking	0.2	0.2	0.7	-0.6	-0.8	-0.2	0.0	0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.2	-0.7	-1.5	-0.1	-0.2	-0.4	0.2
Commuting to job workplace: Car/motor vehicle	1.9	2.2	6.3	1.2	-0.0	2.5	0.8	2.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.7	-0.8	1.9	-0.4	0.3	0.1	-0.8
Medication: Aspirin	0.7	1.0	4.0	-2.0	0.9	-0.4	0.5	0.6	-0.4
Supplements: Vitamin C	1.2	1.4	4.9	1.4	0.2	-1.1	-0.4	-2.2	0.2
Knee pain experienced in last month	0.4	0.6	2.2	-1.0	1.5	-0.4	0.4	-0.1	0.0
Hypertension (Self-reported)	3.1	8.6	19.2	-3.2	2.1	-3.0	-3.0	-0.4	-4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	0.2	1.3	-0.8	-0.4	-0.1	-1.2
Illnesses of father: Heart disease	1.1	1.6	6.1	-0.1	2.5	-0.2	0.7	1.7	-0.3
Illnesses of siblings: Diabetes	0.8	1.0	2.9	-0.2	1.0	-1.0	-0.4	-1.7	-1.0
Smoking status: Previous	1.8	2.6	6.1	-1.3	0.5	-2.5	-2.0	-0.5	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	10.5	3.2	-1.1	0.2	1.1	-1.4	3.0
Whole body fat-free mass	3.8	22.0	70.1	1.6	-4.8	3.0	5.2	0.1	8.4
Leg fat-free mass (right)	3.7	19.7	62.9	1.4	-4.7	2.9	4.9	-0.1	7.9
Arm fat percentage (left)	0.6	2.4	12.0	-3.5	-1.3	-0.7	0.4	-0.4	0.5
Average weekly red wine intake	0.7	1.0	3.0	-0.5	-0.0	-1.6	-0.7	-1.7	-0.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.1	0.9	-0.7	-1.0	-1.4	-1.1	-1.1
Mood swings	0.3	0.5	1.4	-0.2	-0.6	-1.0	0.3	-1.2	0.3
Loneliness, isolation	0.8	1.1	2.9	0.5	-0.1	-1.7	-0.8	-1.5	-0.7
Long-standing illness, disability or infirmity	2.4	3.6	8.6	-2.9	-0.9	-1.6	-1.2	-0.7	-2.8
Ever had bowel cancer screening	1.3	1.6	3.9	0.4	-0.9	2.0	1.6	0.9	1.1
Diabetes diagnosed by doctor	0.8	1.3	6.1	-2.5	0.1	-0.4	0.4	1.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	-0.6	-1.1	0.6	-0.6	0.6	-0.7
Friendships satisfaction	0.5	0.6	1.9	1.4	1.3	-0.1	0.1	-0.2	0.1
Qualifications: nursing, teaching	0.4	0.6	1.8	0.3	1.1	-1.3	-0.5	-0.6	0.3
Commuting to job workplace: Walk	3.0	3.2	10.5	-0.7	0.7	-3.2	-1.6	-2.0	-1.3
Eye problems/disorders: Cataract	0.9	1.1	2.0	0.0	-1.4	-0.4	-1.4	-0.9	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.7	0.8	0.2	-0.2	0.1	-0.3	-0.1
Medication for cholesterol	1.7	2.5	6.6	2.6	-0.1	1.8	0.9	1.1	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.0	1.4	-0.6	0.2	0.5	-1.3	0.7
Back pain experienced in last month	1.6	2.3	7.9	-0.3	-2.8	0.9	0.8	-1.5	1.4
Mineral and other dietary supplements	0.3	0.4	0.8	0.9	0.8	0.4	-0.5	0.6	-0.2
Breast cancer (self-reported)	1.8	2.2	6.6	0.6	-1.8	0.9	1.2	-0.7	2.6
Asthma (self-reported)	12.8	25.5	65.6	-2.7	5.9	-5.8	-3.3	-1.1	-8.1
Osteoporosis (self-reported)	0.4	0.5	1.0	0.9	-0.0	-0.1	1.0	-0.8	0.7
Osteoarthritis (self-reported)	2.1	2.7	7.8	-2.8	-0.3	-1.5	-0.6	-1.9	-1.4
Medication: Aspirin	0.4	0.5	2.2	-1.5	0.3	-0.3	0.3	0.3	-0.4
Medication: Gliclazide	0.8	0.9	3.0	-1.7	-1.5	0.1	0.2	0.2	0.0
Illnesses of father: None of the above (group 1)	0.8	1.0	2.7	1.2	-1.6	0.3	-0.3	-0.9	1.1
Smoking status: Current	1.2	1.9	4.0	0.1	-1.8	2.0	1.2	1.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	5.1	-0.6	-0.4	-1.6	-0.7	-2.2	0.4
Whole body water mass	3.9	22.5	71.4	1.6	-4.8	3.1	5.3	0.2	8.4
Leg predicted mass (right)	3.7	19.7	63.0	1.3	-4.6	2.8	4.9	-0.1	7.9
Arm fat mass (left)	0.9	3.8	8.3	-2.4	-2.3	0.4	1.9	-0.0	2.9
Number of self-reported non-cancer illnesses	3.2	5.6	13.8	-3.4	1.5	-2.3	-1.0	0.1	-3.7
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.4	-0.9	0.7	0.3	0.0	0.5
Miserableness	0.8	1.4	2.9	-0.2	-1.7	-1.6	-0.5	-1.5	0.1
Guilty feelings	0.1	0.2	0.4	0.2	-0.6	-0.5	-0.6	-0.2	-0.2
Wears glasses or contact lenses	0.1	0.1	0.3	-0.2	-0.4	0.5	0.1	0.2	0.0
Ever taken oral contraceptive pill	0.8	0.9	1.7	0.9	1.3	0.9	-0.6	0.8	-1.2
Hearing aid user	2.0	2.3	4.7	0.7	0.7	-1.0	-2.1	-1.6	-2.2
Mother’s age at death	0.4	0.5	1.7	-0.8	-0.4	-1.3	0.1	-0.7	0.3
Financial situation satisfaction	0.5	0.6	1.7	0.8	1.3	-0.4	-0.6	0.5	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.4	0.6	-0.7	-0.2	-0.1	-0.2
Commuting to job workplace: Public transport	0.2	0.3	0.8	0.0	-0.1	-0.9	0.2	-0.7	0.6
Eye problems/disorders: Glaucoma	1.7	2.0	8.8	-3.0	0.7	-0.7	0.9	0.8	0.8
Medication: Blood pressure	2.9	5.5	18.1	-4.2	1.0	-2.3	-0.9	-0.7	-2.7
Pain type(s) experienced in last month: Hip pain	2.1	2.6	6.1	-0.6	-0.6	1.8	2.5	1.3	2.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	-0.3	-0.7	-0.3	-0.4	-0.2	-0.8
High cholesterol (Self-reported)	0.9	1.5	2.7	1.6	1.5	-1.3	-1.1	-0.9	-0.8
Medication: Bendroflumethiazide	3.9	5.9	10.0	-2.6	1.6	-2.9	-2.7	-0.9	-3.2
Medication: Paracetamol	0.4	0.7	1.3	0.8	0.1	-1.0	-0.1	-1.1	1.2
Medication: Lisinopril	1.5	2.0	6.8	-2.6	-0.9	-1.9	-0.6	-0.4	-0.4
Medication: Atorvastatin	0.5	0.7	2.6	0.7	1.6	-0.7	-0.5	-0.5	0.1
Illnesses of father: High blood pressure	1.2	1.5	4.2	0.6	1.2	-1.0	-1.4	-0.4	-2.0
Alcohol drinker status: Never	1.0	1.1	3.3	-0.2	0.6	1.1	1.8	1.3	0.4
Ever smoked	1.6	2.9	6.6	-0.8	-0.5	-2.1	-2.6	-0.2	-2.3
Basal metabolic rate	3.7	20.5	65.9	1.2	-4.6	2.9	5.1	0.2	8.1
Leg fat percentage (left)	1.0	3.5	15.2	-3.9	0.3	-1.8	-0.7	0.0	-1.4
Arm fat-free mass (left)	3.7	18.6	57.2	0.6	-4.3	3.0	5.1	0.9	7.6
Number of operations (self-reported)	1.2	1.8	4.1	0.3	-1.1	2.0	1.6	1.1	1.3
Average weekly beer plus cider intake	2.9	4.2	9.5	0.8	-1.7	3.1	2.3	1.7	2.0
Irritability	0.1	0.2	1.0	0.3	0.0	-0.6	0.1	-1.0	-0.0
Risk taking	0.9	1.3	2.8	-1.0	-0.8	1.3	1.0	1.7	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.0	0.8	0.5	0.3	0.7	0.2
Fractured/broken bones in last 5 years	2.2	2.8	4.9	0.0	-1.5	1.9	2.2	1.3	2.1
Age started oral contraceptive pill	2.3	2.9	7.2	0.4	0.4	2.7	1.7	2.4	1.0
Diastolic blood pressure, automated reading	2.1	6.4	14.7	-1.8	1.8	-2.7	-2.6	-1.8	-3.8
Ever depressed for a whole week	0.3	0.3	0.8	-0.9	0.4	-0.8	0.4	-0.3	0.4
Unable to work because of sickness or disability	1.0	1.2	2.1	-1.3	-1.0	1.3	0.9	1.4	0.5
Commuting to job workplace: Cycle	1.3	1.5	3.6	1.1	-0.1	1.0	1.7	0.7	1.9
Myopia	0.1	0.1	0.3	0.2	0.5	-0.4	-0.0	0.5	-0.1
Vascular/heart problems diagnosed by doctor	3.8	10.5	22.2	2.7	-3.3	3.4	3.2	0.6	4.7
Cholesterol lowering medication	0.3	0.4	1.4	-0.1	-0.0	0.2	1.2	-0.0	0.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.2	-1.5	0.9	-1.3	0.2	-0.7	-1.3
Pain experienced in last month	0.2	0.3	0.6	0.8	-0.6	-0.2	-0.8	-0.1	-0.7
Supplements: Calcium	2.5	2.7	5.6	-0.7	-1.4	1.6	2.4	0.8	2.2
Basal cell carcinoma (self-reported)	0.9	1.1	4.9	0.1	-2.2	1.0	0.2	-0.1	0.8
Heart attack/myocardial infarction (self-reported)	1.5	2.0	6.8	-0.7	2.6	0.4	-0.1	1.8	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.1	-0.9	0.8	0.2	0.5	0.9
Heart disease (siblings)	0.3	0.3	1.3	1.1	0.5	0.6	0.2	0.1	-0.3
Alcohol drinker status: Previous	0.8	0.9	2.3	0.6	-1.5	1.2	0.2	0.5	0.9
Pack years of smoking	2.7	3.9	10.9	1.1	-0.7	3.3	2.1	2.2	1.3
Impedance of whole body	0.2	0.9	2.8	1.1	0.6	0.7	-0.8	-0.1	-1.7
Leg fat mass (left)	0.6	2.2	6.1	-2.5	-1.4	-0.4	1.2	0.1	1.8
Arm predicted mass (left)	3.4	17.5	54.5	0.9	-4.2	2.8	4.9	0.4	7.4