[Hub]/) : Traits : Cardiovascular Disease : ← →

chr7:132,241,297-134,834,499

Best TWAS P=7.48e-09 · Best GWAS P=5.24e-08 conditioned to 0.712

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	EXOC4	0.13	0.05	enet	15	0.04	5.8e-04	-5.1	5.8	7.5e-09	-0.13	0.06	0.89	TRUE
15	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AKR1B15	0.18	0.12	blup	64	0.14	4.5e-07	-5.3	-5.5	4.0e-08	0.88	0.02	0.98	TRUE
3	GTEx	Artery Aorta	EXOC4	0.20	0.14	enet	21	0.20	5.6e-11	-5.2	5.6	2.6e-08	-0.04	0.05	0.94	FALSE
18	The Cancer Genome Atlas	Rectum Adenocarcinoma	AKR1B15	0.37	0.21	lasso	3	0.21	1.2e-05	-5.3	-5.5	4.9e-08	0.94	0.01	0.94	FALSE
7	GTEx	Heart Left Ventricle	AKR1B1	0.25	0.08	lasso	7	0.05	8.5e-04	-5.4	5.4	6.7e-08	-0.90	0.02	0.98	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	EXOC4	0.14	0.15	bslmm	609	0.16	4.4e-20	-5.2	5.4	7.8e-08	-0.01	0.05	0.95	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKR1B15	0.07	0.05	blup	66	0.06	4.5e-07	-5.3	-5.4	8.0e-08	0.91	0.01	0.99	FALSE
4	GTEx	Breast Mammary Tissue	EXOC4	0.14	0.10	lasso	5	0.10	1.3e-05	-5.2	5.3	8.9e-08	-0.07	0.05	0.94	FALSE
5	GTEx	Esophagus Mucosa	EXOC4	0.22	0.13	enet	25	0.18	2.0e-12	-5.2	5.3	1.1e-07	-0.20	0.05	0.95	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	AKR1B15	0.10	0.12	lasso	2	0.12	2.0e-07	-5.3	-5.3	1.2e-07	0.93	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1B15	0.07	0.08	lasso	2	0.08	2.3e-05	-5.3	-5.3	1.2e-07	0.93	0.02	0.97	FALSE
19	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AKR1B10	0.11	0.14	lasso	1	0.13	2.4e-05	-5.3	-5.3	1.2e-07	0.91	0.02	0.96	FALSE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EXOC4	0.10	0.05	lasso	4	0.05	7.3e-04	-5.2	5.2	1.6e-07	-0.01	0.02	0.96	FALSE
6	GTEx	Esophagus Muscularis	EXOC4	0.22	0.13	lasso	4	0.14	8.8e-09	-5.2	5.2	1.8e-07	0.00	0.05	0.95	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	EXOC4	0.17	0.12	lasso	4	0.11	1.7e-10	-5.2	5.2	1.9e-07	-0.01	0.02	0.98	FALSE
9	GTEx	Testis	EXOC4	0.53	0.24	lasso	11	0.30	7.3e-14	-5.1	5.2	2.1e-07	0.05	0.06	0.93	FALSE
10	METSIM	Adipose	EXOC4	0.06	0.06	lasso	6	0.05	6.2e-08	-5.2	5.2	2.1e-07	0.00	0.06	0.94	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	EXOC4	0.16	0.11	lasso	3	0.09	7.2e-06	-5.2	5.2	2.2e-07	-0.01	0.06	0.93	FALSE
17	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AKR1B15	0.31	0.22	lasso	2	0.20	7.7e-09	-5.3	-5.2	2.3e-07	0.93	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXOC4	0.19	0.23	lasso	4	0.24	2.2e-28	-5.1	5.1	2.7e-07	0.00	0.05	0.95	FALSE