Hub : Genes

AKR1B10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0145 0.0084 0.0068 0.011 0.008 0.01 NA 0.009 2.2e-03 6.2e-03 0.0033 NA 5.1e-03
2 TCGA Testicular Germ Cell Tumors 0.1090 0.0560 0.0002 0.140 0.124 0.11 NA 0.130 1.2e-05 3.7e-05 0.0001 NA 2.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.7 1.0 -1.0 0.7
Bipolar Disorder or Schizophrenia 1.0 2.5 4.7 -2.2 0.6
Depressed Affect (Nagel 2018) 0.8 1.6 2.4 -1.5 -0.9
Depression (Nagel 2018) 0.6 1.0 1.4 -0.7 -1.2
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.3 0.4 0.5
Neuroticism (Nagel 2018) 0.1 0.1 0.2 -0.5 -0.2
Schizophrenia (2018) 0.9 2.0 3.9 -2.0 0.2
Schizophrenia vs Biploar Disorder 1.1 1.5 2.7 -1.7 0.5
Worry (Nagel 2018) 0.0 0.1 0.2 0.1 -0.4
Alzheimer’s Disease (in mother) 0.4 0.5 0.6 -0.8 0.6
Alzheimer’s Disease (in father) 1.6 1.8 3.4 -1.8 -0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 0.9 -0.9 0.7
Crohns Disease (2017) 0.5 1.2 1.6 -0.9 1.3
Irritable Bowel Disease (IBD) 0.7 1.8 2.4 -1.1 1.6
Ulcerative Colitis (UC) 0.2 0.3 0.4 -0.5 0.7
Major Depression (MDD) 0.3 0.3 0.4 0.5 -0.7
Reaction Time 0.0 0.1 0.1 0.3 -0.1
Verbal and Numeric Reasoning (VNR) 1.6 3.8 6.0 2.4 -1.3
Breast Cancer 0.0 0.1 0.2 0.1 0.4
Ovarian Cancer 0.6 0.8 1.0 -1.0 0.7
Prostate Cancer 0.8 1.1 1.5 1.2 -0.9
Age at First Birth 0.3 0.5 0.5 -0.6 0.7
Bipolar Disorder (2011) 1.2 1.2 2.1 -0.5 -1.4
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 -0.5 -0.0
Coronary Artery Disease (CAD) 0.4 0.5 1.0 -0.2 -1.0
Crohns Disease (2012) 0.4 0.6 0.9 -1.0 0.5
Mean Putamen Volume 0.1 0.1 0.2 -0.2 -0.4
Fasting Glucose 0.1 0.2 0.2 0.4 -0.4
HbA1C 0.3 0.3 0.4 -0.5 0.6
HDL Cholesterol 0.9 1.5 1.8 1.3 -1.1
LDL Cholesterol 0.6 1.0 1.4 1.2 -0.7
Lupus 0.0 0.1 0.1 -0.2 -0.2
Neuroticism (2016) 0.6 0.9 1.7 -0.1 1.3
Primary Biliary Cirrhosis 1.3 1.9 2.9 -1.7 0.9
Rheumatoid Arthritis 0.4 0.5 1.0 -0.2 1.0
Schizophrenia (2014) 0.5 1.1 2.2 -1.5 -0.1
Triglycerides 1.8 3.0 5.9 -0.1 2.4
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.3 0.6 -0.0
Ulcerative Colitis 0.6 0.9 1.7 -1.3 0.4
Blood Eosinophil Count 0.2 1.4 2.8 0.2 -1.7
Blood Platelet Count 0.2 2.7 5.4 -2.3 0.2
Blood Red Count 0.1 1.2 2.0 0.6 1.4
Blood White Count 0.1 0.8 1.0 -1.0 -0.8
Heel T-Score 0.3 2.2 4.1 2.0 0.5
BMI 0.0 0.0 0.1 0.2 0.2
Height 0.0 0.2 0.4 -0.6 0.0
Waist Hip Ratio (WHR) 0.2 0.9 1.7 -1.3 0.3
Systolic Blood Pressure 5.9 29.7 47.7 3.4 -6.9
Smoking Status 1.3 3.2 3.5 -1.9 1.7
Allergy or Eczema 0.1 0.4 0.4 -0.6 -0.6
Cardiovascular Disease 5.4 17.9 28.0 2.8 -5.3
Hypothyroidism (self reported) 0.2 0.5 0.9 -0.4 0.9
Respiratory disease 0.3 0.7 1.2 0.4 -1.1
Type 2 Diabetes (T2D) (2018) 0.9 1.6 2.2 -1.5 -1.0
Lung FEV1/FVC ratio 0.5 2.5 4.5 2.1 0.8
Lung FVC 1.5 7.6 8.4 2.6 -2.9
Neuroticism 0.8 1.9 3.6 -1.9 0.2
Chronotype (morning person) 0.8 1.8 2.8 -1.7 -0.9
Hair Pigment 0.1 2.1 4.2 0.1 2.0
Tanning 0.1 1.2 2.2 -0.5 1.5
Hand grip strength (left) 0.6 1.6 3.1 1.8 -0.3
Number of treatments/medications taken 0.0 0.0 0.0 0.2 -0.1
Average weekly spirits intake 2.6 3.2 4.5 -2.1 1.4
Sensitivity / hurt feelings 0.6 1.1 2.0 -1.4 -0.4
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.9 -0.7 -1.4
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.3 -0.4
Relative age of first facial hair 1.3 2.6 4.2 2.0 1.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.4 0.6 0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 0.4 -0.6
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 -0.3 0.6
Systolic blood pressure, automated reading 2.0 5.8 7.0 2.1 -2.7
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.3 -0.9 1.8
Angina 0.8 1.1 2.1 -1.5 -0.2
Medication for hormone replacement therapy 2.7 3.1 6.1 -2.5 -0.1
Vitamin and mineral supplements 0.2 0.2 0.3 -0.5 -0.5
Supplements: Zinc 1.2 1.3 2.1 -0.7 1.5
Medication: Co-codamol 0.5 0.5 0.6 0.7 0.8
Medication: Metformin 0.6 0.8 1.5 -1.2 -0.3
Diabetes (father) 3.6 4.5 8.5 -2.9 0.7
Diabetes (mother) 0.3 0.4 0.8 -0.9 -0.0
Severe depression (siblings) 2.6 2.9 3.6 -1.9 1.5
Pack years adult smoking proportion 0.3 0.5 0.9 -0.3 -1.0
Impedance of leg (right) 0.6 2.8 3.3 -1.5 1.8
Leg fat-free mass (left) 0.0 0.2 0.4 0.6 -0.1
Trunk fat percentage 1.4 5.7 7.3 -2.0 2.7
Hand grip strength (right) 0.7 1.9 2.9 1.7 -0.9
Townsend deprivation index at recruitment 0.1 0.2 0.4 -0.6 0.2
Current tobacco smoking 1.7 2.7 3.7 -1.3 1.9
Average weekly fortified wine intake 0.7 0.8 1.1 -0.7 1.1
Maternal smoking around birth 0.5 0.7 1.3 -1.1 -0.2
Fed-up feelings 0.7 1.3 1.9 -1.4 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 6.7 0.8 -2.6
Relative age voice broke 0.5 0.8 1.5 1.2 -0.2
Taking other prescription medications 0.0 0.1 0.1 -0.1 0.3
Age when periods started (menarche) 1.1 2.7 3.2 -1.8 1.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.0 1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.3 0.2 0.6
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 1.7 -1.3 0.8
Qualifications: CSEs or equivalent 1.2 1.6 2.5 -0.9 1.6
Serious illness, injury or assault to yourself 0.5 0.6 0.8 -0.9 -0.5
High blood pressure 5.6 15.6 25.1 2.5 -5.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.2 1.1 -0.9
Multivitamins +/- minerals 0.1 0.2 0.4 0.1 0.6
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.5 0.2
Supplements: Glucosamine 0.1 0.1 0.1 -0.3 0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.7 0.0
Medication: Atenolol 0.5 0.6 1.2 -0.1 -1.1
Medication: Levothyroxine sodium 0.7 1.2 1.5 -1.2 1.0
Sitting height 0.1 0.8 1.1 1.0 -0.7
Chronic bronchitis/emphysema (father) 1.1 1.2 2.3 0.4 -1.5
High blood pressure (mother) 0.8 1.1 1.9 0.5 -1.4
Body mass index (BMI) 0.1 0.3 0.5 -0.4 0.7
Impedance of leg (left) 0.8 3.8 4.0 -1.9 2.0
Leg predicted mass (left) 0.0 0.2 0.3 0.6 -0.1
Trunk fat mass 0.9 3.9 5.1 -1.6 2.3
Waist circumference 0.8 3.0 3.9 -1.4 2.0
Number of incorrect matches in round 1.0 1.6 1.9 -1.2 1.4
Past tobacco smoking 0.1 0.1 0.2 -0.1 -0.5
Alcohol usually taken with meals 0.4 0.6 1.0 -0.5 -1.0
Nervous feelings 0.1 0.2 0.5 -0.7 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 3.8 -1.9 -0.3
Hearing difficulty/problems with background noise 0.8 1.2 2.1 -0.6 -1.5
Hair/balding pattern: Pattern 2 0.6 0.8 1.5 0.2 1.2
Had menopause 0.2 0.3 0.5 0.7 -0.3
Had other major operations 0.3 0.3 0.3 0.6 -0.6
Forced vital capacity (FVC) 0.9 3.5 3.7 1.9 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.7 -0.4 0.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.2 -1.1 0.5
Qualifications: None of the above 0.2 0.4 0.8 0.1 -0.9
Financial difficulties in last 2 years 0.8 1.0 2.0 -1.4 -0.2
Mouth/teeth dental problems 1.2 1.8 2.2 1.5 -1.2
Heart attack 1.0 1.3 1.6 -1.3 1.0
Allergy 1.0 2.2 2.9 -1.7 1.2
Pain all over the body in last month 0.7 0.7 1.4 -1.2 0.2
Diabetes (self-reported) 0.2 0.3 0.4 -0.6 0.6
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 1.5 1.2 -1.0
Medication: Ramipril 2.0 2.6 4.8 0.6 -2.2
Medication: Simvastatin 0.5 0.7 0.7 -0.8 -0.9
Fluid intelligence score 1.2 2.5 3.4 1.3 -1.8
Illnesses of siblings 0.4 0.5 0.6 0.8 0.7
Neuroticism score 0.4 0.8 1.4 -1.2 -0.3
Weight 0.1 0.5 0.9 -0.3 1.0
Impedance of arm (right) 1.0 4.6 5.0 -2.0 2.2
Arm fat percentage (right) 0.8 3.1 3.4 -1.7 1.8
Trunk fat-free mass 0.3 1.8 2.1 1.4 -1.3
Hip circumference 0.4 1.6 2.0 -1.1 1.4
Time employed in main current job 0.6 0.7 0.8 -0.9 -0.7
Alcohol intake versus 10 years previously 1.0 1.4 1.5 -1.2 1.2
Father’s age at death 0.9 1.3 2.4 -1.6 -0.4
Worrier / anxious feelings 0.9 1.8 2.0 -1.4 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.6 -1.3 0.1
Falls in the last year 1.4 1.8 3.7 -0.0 -1.9
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 0.3 0.4
Number of live births 0.1 0.1 0.1 0.0 0.4
Forced expiratory volume in 1-second (FEV1) 1.3 4.5 5.6 2.4 -1.9
Pulse rate 1.5 2.5 2.8 -1.5 1.7
Happiness 1.4 1.7 3.3 -0.2 -1.8
Noisy workplace 1.2 1.5 2.3 -0.9 1.5
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 -0.3 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.5 0.3 0.7
Mouth/teeth dental problems: Dentures 0.4 0.7 1.1 -1.1 0.5
Asthma 0.5 0.9 1.2 0.8 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.0 1.0 0.7
Medication: Cholesterol lowering 0.0 0.0 0.0 0.2 0.2
Depression (self-reported) 0.4 0.4 0.5 0.7 0.6
Medication: Lansoprazole 0.3 0.4 0.5 -0.6 0.7
Prospective memory result 0.3 0.3 0.4 0.5 0.7
Lung cancer (father) 0.3 0.4 0.7 0.2 0.9
Illnesses of mother 0.2 0.3 0.4 -0.7 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.9 6.9 2.6 -2.2
Pulse wave Arterial Stiffness index 0.1 0.2 0.3 -0.2 -0.5
Impedance of arm (left) 1.3 5.9 7.0 -2.2 2.7
Arm fat mass (right) 0.4 1.7 1.8 -1.3 1.4
Trunk predicted mass 0.3 1.7 1.8 1.3 -1.3
Standing height 0.0 0.2 0.2 0.5 0.4
Length of working week for main job 0.6 0.6 1.3 0.0 -1.1
Exposure to tobacco smoke at home 0.1 0.1 0.1 -0.2 -0.3
Breastfed as a baby 0.6 0.7 1.2 1.1 -0.5
Tense / ‘highly strung’ 0.3 0.5 0.6 0.6 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.5 -0.0 -0.7
Hair/balding pattern: Pattern 4 0.7 1.8 3.3 -0.6 -1.8
Birth weight of first child 0.5 1.0 1.5 -1.2 0.7
Peak expiratory flow (PEF) 1.1 2.4 3.1 1.8 -1.4
Pulse wave reflection index 0.4 0.5 0.6 -0.6 -0.8
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.4 -1.2 0.6
Loud music exposure frequency 1.0 1.1 2.2 -1.5 -0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.4 0.9 -1.2
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 3.6 -0.6 1.9
Blood clot in the leg (DVT) 2.8 3.6 4.5 1.6 -2.1
Medication: Paracetamol 0.6 0.9 1.4 -0.7 1.2
Headache pain in last month 0.5 0.8 1.1 1.1 -0.6
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 1.8 -1.0 1.3
Glaucoma (self-reported) 0.3 0.4 0.7 -0.3 0.8
Gout (self-reported) 0.0 0.0 0.0 0.1 0.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.9 -0.4 1.0
Medication: Amlodipine 6.6 9.3 11.3 3.4 -2.7
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.1 0.4
Birth weight 0.0 0.1 0.1 -0.1 -0.3
Chronic bronchitis/emphysema (mother) 6.1 7.2 8.0 -2.5 2.8
High blood pressure (siblings) 1.7 2.5 5.0 0.2 -2.2
Forced vital capacity (FVC), Best measure 1.1 4.1 4.9 2.2 -1.9
Body fat percentage 1.7 6.6 7.2 -2.5 2.7
Leg fat percentage (right) 1.4 5.0 5.9 -2.4 2.0
Arm fat-free mass (right) 0.1 0.5 0.8 0.9 -0.4
Exposure to tobacco smoke outside home 1.0 1.3 2.4 1.6 -0.3
Comparative body size at age 10 0.3 0.9 1.7 -1.3 -0.0
Number of full brothers 0.6 0.7 1.3 -1.1 0.4
Worry too long after embarrassment 0.7 1.2 2.5 -0.1 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 -0.3 0.7
Wheeze or whistling in the chest in last year 0.4 0.8 1.5 -0.3 1.2
Number of children fathered 1.3 1.5 2.0 -1.4 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.1 -0.2 0.4
Age at first live birth 0.1 0.2 0.5 0.7 0.1
Pulse wave peak to peak time 0.1 0.1 0.2 0.2 0.4
Health satisfaction 0.4 0.5 0.9 -0.4 -1.0
Shortness of breath walking on level ground 0.5 0.6 0.8 -0.9 -0.6
Qualifications: College or University degree 0.1 0.3 0.3 0.6 -0.6
Eye problems/disorders: None of the above 1.1 1.3 1.5 1.0 -1.2
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.7 -1.6 0.5
Emphysema/chronic bronchitis 0.8 0.9 1.1 1.0 0.8
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 0.6 -0.1
Neck or shoulder pain in last month 0.0 0.0 0.0 -0.1 -0.0
Medication: Blood pressure 3.0 5.2 7.6 1.7 -2.8
Angina (self-reported) 0.8 1.0 2.0 -1.4 -0.3
Migraine (self-reported) 1.5 1.8 2.3 1.5 -1.2
Medication: Ibuprofen 0.7 0.9 1.7 0.1 1.3
Medication: Allopurinol 0.5 0.7 1.3 0.4 -1.1
Medication: Omeprazole 0.2 0.3 0.5 -0.0 0.7
Medication: Seretide 50 evohaler 0.0 0.0 0.0 0.0 -0.1
Mean time to correctly identify matches 0.1 0.2 0.2 0.4 -0.5
Heart disease (mother) 0.6 0.7 1.4 1.2 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 1.7 1.3 -1.3
Whole body fat mass 0.8 3.1 3.6 -1.6 1.9
Leg fat mass (right) 0.8 3.0 3.2 -1.7 1.8
Arm predicted mass (right) 0.1 0.3 0.5 0.7 -0.3
Pulse rate, automated reading 1.6 5.3 7.9 -1.6 2.8
Alcohol intake frequency. 1.1 2.6 4.3 -1.0 2.1
Comparative height size at age 10 0.0 0.1 0.2 0.5 -0.1
Number of full sisters 1.1 1.4 2.6 0.4 1.6
Suffer from ‘nerves’ 0.5 0.7 1.1 1.1 -0.5
Overall health rating 0.2 0.4 0.4 -0.7 -0.6
Chest pain or discomfort 0.7 1.0 1.9 -1.4 -0.0
Had major operations 0.4 0.5 0.9 -0.3 1.0
Age at last live birth 0.1 0.1 0.2 -0.1 -0.5
Family relationship satisfaction 0.3 0.3 0.6 -0.0 -0.8
Leg pain on walking 0.1 0.1 0.1 0.3 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 -0.2 -0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.6 -0.6 0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.2 1.1 0.7
Medication: Aspirin 2.0 2.6 4.1 1.1 -2.0
Supplements: Vitamin C 1.4 1.6 3.2 1.8 -0.2
Knee pain experienced in last month 0.9 1.4 2.0 -1.0 1.4
Hypertension (Self-reported) 7.2 20.0 30.9 3.0 -5.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 1.9 0.8 -1.4
Illnesses of father: Heart disease 0.6 0.8 1.1 0.6 1.1
Illnesses of siblings: Diabetes 1.2 1.5 2.8 -0.5 1.7
Smoking status: Previous 0.1 0.2 0.2 0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 0.5 0.5
Whole body fat-free mass 0.2 0.9 1.1 1.1 -0.8
Leg fat-free mass (right) 0.0 0.2 0.4 0.6 -0.2
Arm fat percentage (left) 1.1 4.5 5.5 -1.9 2.3
Average weekly red wine intake 1.0 1.4 1.6 1.1 -1.3
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.3 0.1
Mood swings 0.1 0.2 0.3 -0.2 -0.6
Loneliness, isolation 0.5 0.7 1.3 -0.3 -1.1
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.5 -0.1
Ever had bowel cancer screening 1.3 1.6 2.4 -1.6 0.8
Diabetes diagnosed by doctor 0.2 0.3 0.6 -0.8 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.2 -0.2 1.1
Friendships satisfaction 2.2 2.7 4.5 1.0 -2.1
Qualifications: nursing, teaching 0.1 0.1 0.2 -0.3 0.4
Commuting to job workplace: Walk 0.3 0.3 0.5 -0.7 0.2
Eye problems/disorders: Cataract 1.3 1.5 2.2 -0.9 1.5
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 0.3 -0.4
Medication for cholesterol 4.2 6.4 12.6 -0.4 3.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 2.0 -1.2 1.4
Back pain experienced in last month 0.0 0.0 0.0 -0.2 -0.1
Mineral and other dietary supplements 0.0 0.0 0.0 -0.0 -0.0
Breast cancer (self-reported) 0.2 0.3 0.6 0.1 -0.7
Asthma (self-reported) 0.6 1.3 1.7 0.9 -1.3
Osteoporosis (self-reported) 0.8 1.0 1.9 -1.4 0.4
Osteoarthritis (self-reported) 0.9 1.2 2.4 0.2 1.5
Medication: Aspirin 1.6 2.1 2.9 1.1 -1.7
Medication: Gliclazide 0.1 0.2 0.3 -0.5 0.2
Illnesses of father: None of the above (group 1) 1.3 1.5 1.8 1.4 -1.1
Smoking status: Current 1.6 2.5 4.1 -1.0 2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.4 9.2 10.2 3.2 -2.9
Whole body water mass 0.1 0.8 1.1 1.0 -0.7
Leg predicted mass (right) 0.0 0.2 0.3 0.6 -0.2
Arm fat mass (left) 0.4 1.6 1.6 -1.2 1.3
Number of self-reported non-cancer illnesses 0.7 1.3 1.4 1.2 -1.1
Average weekly champagne plus white wine intake 0.7 1.0 2.0 -0.3 -1.4
Miserableness 0.2 0.4 0.8 -0.0 -0.9
Guilty feelings 0.8 1.2 2.3 -1.5 0.2
Wears glasses or contact lenses 0.1 0.1 0.2 0.2 -0.5
Ever taken oral contraceptive pill 0.0 0.0 0.0 -0.2 0.2
Hearing aid user 3.2 3.7 6.9 -2.6 -0.6
Mother’s age at death 1.3 1.7 2.6 1.6 0.8
Financial situation satisfaction 1.1 1.4 1.7 -1.3 1.0
Tinnitus: Yes, now most or all of the time 1.7 1.9 2.8 -1.0 1.7
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.1 0.5
Eye problems/disorders: Glaucoma 0.2 0.3 0.3 -0.5 0.6
Medication: Blood pressure 4.9 9.3 15.3 1.8 -3.9
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.6 -0.7 -0.8
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 0.4 0.6
High cholesterol (Self-reported) 0.1 0.2 0.5 -0.7 0.2
Medication: Bendroflumethiazide 4.4 6.7 9.7 1.9 -3.1
Medication: Paracetamol 0.3 0.5 0.9 -0.2 0.9
Medication: Lisinopril 0.9 1.2 1.7 0.8 -1.3
Medication: Atorvastatin 0.7 0.8 1.6 1.3 -0.2
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.6 -0.2
Alcohol drinker status: Never 2.4 2.9 5.2 -0.7 2.3
Ever smoked 0.3 0.6 0.8 -0.6 0.9
Basal metabolic rate 0.0 0.3 0.4 0.7 -0.3
Leg fat percentage (left) 1.5 5.5 6.7 -2.6 2.1
Arm fat-free mass (left) 0.1 0.3 0.3 0.5 -0.6
Number of operations (self-reported) 0.0 0.0 0.0 -0.0 0.2
Average weekly beer plus cider intake 0.3 0.5 0.7 0.9 -0.5
Irritability 0.0 0.0 0.1 -0.1 0.2
Risk taking 1.5 2.3 3.7 -0.9 1.9
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.5 1.6 -0.7
Fractured/broken bones in last 5 years 2.7 3.5 6.5 -0.7 2.5
Age started oral contraceptive pill 1.3 1.6 3.0 0.4 -1.7
Diastolic blood pressure, automated reading 1.1 3.5 3.7 1.9 -1.8
Ever depressed for a whole week 0.2 0.3 0.5 -0.4 0.7
Unable to work because of sickness or disability 0.4 0.5 0.7 -0.9 -0.5
Commuting to job workplace: Cycle 0.6 0.7 1.1 -1.0 -0.5
Myopia 0.5 0.7 1.4 -0.1 1.2
Vascular/heart problems diagnosed by doctor 4.0 11.0 19.3 -1.7 4.4
Cholesterol lowering medication 1.3 1.9 3.9 0.1 -2.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.7 -0.3 1.3
Pain experienced in last month 0.3 0.5 0.6 0.8 -0.6
Supplements: Calcium 0.3 0.4 0.6 0.8 -0.3
Basal cell carcinoma (self-reported) 0.4 0.5 0.9 1.0 0.3
Heart attack/myocardial infarction (self-reported) 1.0 1.3 1.5 -1.2 1.1
Deep venous thrombosis (DVT) (self-reported) 2.4 3.0 3.4 1.6 -1.9
Heart disease (siblings) 0.3 0.3 0.6 -0.3 0.8
Alcohol drinker status: Previous 0.1 0.1 0.2 0.0 0.5
Pack years of smoking 0.4 0.7 1.3 -0.0 -1.1
Impedance of whole body 1.1 5.5 5.7 -2.3 2.4
Leg fat mass (left) 0.8 3.1 3.4 -1.7 1.8
Arm predicted mass (left) 0.1 0.3 0.5 0.5 -0.7