Hub : Genes

SLC35D1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1700	0.0520	2.0e-04	0.042	NA	0.049	NA	0.025	4.2e-04	NA	1.5e-04	NA	5.1e-03
2	GTEx	Skin Sun Exposed Lower leg	0.0860	0.0370	4.7e-03	0.045	NA	0.037	NA	0.045	1.2e-04	NA	5.0e-04	NA	1.2e-04
3	GTEx	Stomach	0.2190	0.0720	1.4e-04	0.035	NA	0.076	NA	-0.005	8.6e-03	NA	1.7e-04	NA	6.8e-01
4	GTEx	Whole Blood	0.2700	0.0650	8.1e-05	0.141	NA	0.123	NA	0.126	6.4e-13	NA	2.1e-11	NA	1.1e-11
5	ROSMAP	Brain Pre-frontal Cortex	0.0887	0.0297	2.0e-04	0.067	0.038	0.056	0.064	0.061	5.0e-09	1.0e-05	9.3e-08	1.3e-08	2.8e-08
6	TCGA	Thyroid Carcinoma	0.1260	0.0380	5.6e-17	0.105	0.178	0.196	NA	0.195	2.0e-10	4.2e-17	9.2e-19	NA	1.1e-18

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.8	1.5	-1.1	-0.8	-1.2	-0.1	-0.8	-0.8
Bipolar Disorder or Schizophrenia	0.6	1.3	3.7	-1.9	-1.1	-1.2	-0.8	-0.6	-0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	-0.2	-0.9	0.6	-1.2	-0.6	-0.7
Depression (Nagel 2018)	1.3	1.9	3.0	-1.6	-1.7	0.3	-1.7	-0.5	-1.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.1	1.8	0.8	-0.4	1.3	-0.2	0.7
Neuroticism (Nagel 2018)	1.0	2.3	4.1	-0.9	-2.0	0.6	-1.4	-1.6	-2.0
Schizophrenia (2018)	0.4	0.8	2.5	-1.6	-0.8	-0.5	-0.9	-0.0	-0.6
Schizophrenia vs Biploar Disorder	1.1	1.5	3.1	-1.0	-1.4	1.2	0.0	-1.8	-1.2
Worry (Nagel 2018)	2.0	4.1	11.2	-1.0	-2.8	-0.1	-1.5	-1.5	-3.3
Alzheimer’s Disease (in mother)	0.5	0.5	2.2	0.7	0.1	-0.5	1.5	-0.4	0.4
Alzheimer’s Disease (in father)	0.8	0.9	2.7	0.6	-0.1	-1.4	1.6	0.2	-0.4
Alzheimer’s Disease (including proxy)	1.5	2.1	4.3	2.0	1.2	-0.9	2.1	0.5	1.4
Crohns Disease (2017)	1.0	2.1	7.0	2.3	0.0	-2.6	0.1	-0.3	0.6
Irritable Bowel Disease (IBD)	3.1	7.4	12.8	3.6	2.4	-1.9	2.6	2.1	3.3
Ulcerative Colitis (UC)	5.0	9.4	16.4	3.0	3.1	-0.4	3.6	2.8	4.0
Major Depression (MDD)	0.8	1.0	2.4	-1.5	-1.0	0.1	-0.9	-0.4	-1.3
Reaction Time	3.4	6.5	15.1	-1.7	-3.1	-1.2	-2.7	-1.6	-3.9
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.2	-0.1	-0.0	-1.1	0.8	-0.4	-0.1
Breast Cancer	0.2	0.4	0.8	-0.9	-0.5	0.3	0.4	0.6	-0.9
Ovarian Cancer	1.6	2.1	4.3	-1.3	-1.8	-0.8	-0.2	-1.7	-2.1
Prostate Cancer	0.2	0.2	0.9	-0.9	-0.5	-0.1	0.1	-0.2	-0.4
Age at First Birth	0.5	0.7	3.3	0.3	0.1	0.8	-1.8	-0.5	0.2
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.1	0.5	0.5	0.0	0.6	0.5
Body Mass Index (BMI) (2010)	1.4	2.0	4.3	-0.9	1.3	2.1	-0.7	1.5	1.6
Coronary Artery Disease (CAD)	0.2	0.3	1.0	-0.3	-0.1	0.4	1.0	0.1	-0.4
Crohns Disease (2012)	0.4	0.6	1.8	1.3	-0.1	-1.4	0.0	0.0	0.3
Mean Putamen Volume	0.5	0.6	0.9	-0.8	-0.9	0.8	-0.5	-0.7	-0.6
Fasting Glucose	0.6	0.7	1.9	0.4	0.4	-0.7	1.1	1.4	-0.7
HbA1C	0.4	0.5	1.0	1.0	0.5	-0.6	-0.8	0.6	-0.6
HDL Cholesterol	0.7	1.2	2.2	-0.4	-1.5	-0.8	0.0	-1.5	-1.5
LDL Cholesterol	0.4	0.7	1.7	-0.5	-0.1	1.3	1.2	-0.5	0.4
Lupus	0.8	1.2	3.5	-1.9	-0.7	1.2	-0.6	-0.7	-0.9
Neuroticism (2016)	0.8	1.2	3.3	-1.8	-0.9	0.4	0.0	-0.3	-1.6
Primary Biliary Cirrhosis	3.3	4.6	8.7	-3.0	-2.4	-0.6	-0.5	-2.6	-2.5
Rheumatoid Arthritis	1.9	2.6	4.5	-1.3	-2.0	0.8	-1.2	-1.8	-2.1
Schizophrenia (2014)	1.2	2.6	4.1	-1.7	-2.0	-0.8	-1.7	-1.6	-1.5
Triglycerides	2.1	3.5	8.1	1.1	2.3	1.5	0.3	2.9	2.1
Type 2 Diabetes (T2D) (2012)	5.8	6.7	16.3	-2.8	-2.8	-0.8	-2.1	-4.0	-1.8
Ulcerative Colitis	1.8	2.6	5.0	1.4	1.9	-1.0	0.0	2.0	2.2
Blood Eosinophil Count	0.2	1.8	5.1	-1.8	-0.1	1.3	2.3	0.7	-0.2
Blood Platelet Count	0.2	1.9	2.9	1.6	1.5	-1.1	1.7	1.0	1.2
Blood Red Count	0.1	0.5	1.3	-1.1	-0.3	-0.4	-1.1	0.3	-0.5
Blood White Count	1.6	12.0	37.5	2.3	4.0	0.0	2.2	2.9	6.1
Heel T-Score	0.4	3.0	6.6	-2.6	0.6	1.8	-0.3	2.5	1.0
BMI	0.1	0.8	2.7	-1.6	-0.3	0.0	-1.1	-0.7	0.4
Height	0.8	15.1	38.3	-3.2	-4.2	-3.9	3.0	-0.1	-6.2
Waist Hip Ratio (WHR)	0.4	1.8	3.1	1.3	1.2	0.8	1.4	-1.5	1.8
Systolic Blood Pressure	1.6	7.8	19.5	-2.1	-3.6	0.3	0.2	-3.2	-4.4
Smoking Status	0.3	0.6	1.3	0.3	-0.8	0.8	0.9	-0.7	-1.1
Allergy or Eczema	1.1	3.0	11.2	-0.4	-1.9	-1.1	-1.3	-0.3	-3.4
Cardiovascular Disease	2.1	6.8	15.0	-2.2	-3.2	-0.3	0.4	-3.9	-3.2
Hypothyroidism (self reported)	0.5	1.0	2.0	-1.3	0.1	0.4	1.4	-1.0	1.1
Respiratory disease	0.5	1.2	3.1	-0.9	-1.4	-1.0	-0.1	-0.7	-1.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.7	0.0	0.6	0.5	1.4	-0.2	1.6
Lung FEV1/FVC ratio	0.5	2.4	9.1	-0.5	-0.8	1.0	-3.0	-0.7	-1.7
Lung FVC	0.3	1.4	3.8	-0.2	-0.6	-2.0	-1.9	-0.1	-0.7
Neuroticism	1.1	2.7	5.5	-0.8	-1.9	1.1	-1.9	-2.3	-1.4
Chronotype (morning person)	0.1	0.3	1.2	-1.1	-0.3	-0.2	0.5	0.2	0.7
Hair Pigment	0.0	1.4	7.3	-0.6	-0.6	0.6	-2.7	-0.1	-0.0
Tanning	0.1	1.7	6.6	-1.8	0.1	-0.1	-2.6	0.6	0.3
Hand grip strength (left)	0.9	2.3	11.2	0.7	0.7	0.2	3.3	1.3	-0.3
Number of treatments/medications taken	0.0	0.1	0.2	0.3	0.2	-0.4	-0.2	-0.3	-0.2
Average weekly spirits intake	0.4	0.5	1.0	0.6	0.1	-0.6	-1.0	0.7	-0.9
Sensitivity / hurt feelings	0.5	0.9	2.2	0.0	0.9	1.5	0.6	0.0	1.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-0.9	-0.6	-0.4	0.1	0.8	-1.1
Hearing difficulty/problems: Yes	1.1	1.7	5.0	1.0	-0.8	-0.9	2.2	-1.7	0.0
Relative age of first facial hair	0.3	0.6	1.4	0.9	-0.4	0.3	-1.2	-1.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	0.4	-0.3	-1.3	0.6	-0.1	-1.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.1	-0.3	-0.5	-0.1	-0.2	-0.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	-0.7	-0.8	-1.6	-0.4	0.8	-1.1
Systolic blood pressure, automated reading	0.9	2.5	6.2	-0.5	-2.0	-0.7	1.3	-1.5	-2.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.3	0.8	0.7	1.8	0.2	0.2	1.2
Angina	0.3	0.3	0.7	0.6	0.1	0.8	-0.9	-0.3	0.4
Medication for hormone replacement therapy	1.0	1.1	2.7	0.8	1.4	-0.1	0.3	1.6	1.0
Vitamin and mineral supplements	0.4	0.6	2.9	1.7	0.5	0.7	-0.2	-0.0	-0.1
Supplements: Zinc	1.4	1.6	4.6	-1.6	-1.1	-2.1	0.3	-0.6	-0.7
Medication: Co-codamol	0.8	0.9	2.7	-0.2	-0.7	-1.6	-1.0	-0.8	-0.7
Medication: Metformin	0.4	0.5	1.3	-1.1	-0.7	0.5	0.4	-0.8	-0.5
Diabetes (father)	0.5	0.7	1.1	1.0	1.0	0.1	0.4	0.9	1.0
Diabetes (mother)	0.8	1.0	2.9	-1.7	-1.0	0.0	-0.1	-1.1	-1.0
Severe depression (siblings)	1.4	1.6	4.3	-1.5	-1.4	0.6	-0.3	-2.1	-0.8
Pack years adult smoking proportion	0.7	1.1	3.5	-1.5	-0.1	-0.7	1.9	0.6	-0.4
Impedance of leg (right)	0.4	2.0	6.5	2.5	1.1	-0.1	1.6	0.5	1.2
Leg fat-free mass (left)	0.7	3.5	9.5	-3.1	-1.7	-1.5	-0.4	0.1	-2.5
Trunk fat percentage	0.4	1.7	4.6	-1.5	-0.9	-2.1	-1.1	-0.8	-0.9
Hand grip strength (right)	1.0	2.7	9.8	0.3	1.2	0.8	3.1	2.1	0.2
Townsend deprivation index at recruitment	1.6	2.2	5.2	0.3	1.0	2.3	1.8	-1.2	1.4
Current tobacco smoking	0.5	0.7	1.8	-0.6	-0.5	1.3	0.9	-0.8	-0.6
Average weekly fortified wine intake	0.8	0.9	1.6	-1.1	-0.6	1.3	-0.8	-1.3	0.2
Maternal smoking around birth	0.9	1.4	4.2	-0.4	-1.2	-1.1	1.0	-2.0	-0.4
Fed-up feelings	1.1	2.0	4.0	-2.0	-1.6	0.4	-1.1	-1.4	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.6	-1.6	-0.9	0.8	-1.3	-0.7	-0.4
Relative age voice broke	2.1	3.2	5.3	2.2	2.3	0.9	-0.3	2.3	1.8
Taking other prescription medications	0.1	0.1	0.3	-0.1	0.5	0.4	-0.0	0.4	-0.4
Age when periods started (menarche)	0.2	0.5	1.3	0.8	-0.0	0.6	1.1	0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.6	0.3	-0.2	-1.3	0.1	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.4	-0.7	0.1	1.9	0.7	1.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.7	-0.1	-0.3	0.3	-0.8	-0.3	-0.1
Qualifications: CSEs or equivalent	0.5	0.6	2.4	-1.2	0.0	-0.0	-1.6	0.2	-0.2
Serious illness, injury or assault to yourself	0.6	0.8	1.5	0.6	-0.5	-1.2	0.2	-1.1	-1.2
High blood pressure	1.6	4.5	10.5	-0.5	-2.6	-0.7	1.1	-3.2	-2.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.9	0.2	-1.1	-0.4	-0.2	-0.3	-2.2
Multivitamins +/- minerals	0.3	0.4	1.9	-1.4	0.1	-0.2	0.1	0.5	0.4
Stomach or abdominal pain in last month	0.6	0.7	1.2	1.1	0.8	0.9	0.9	0.9	0.2
Supplements: Glucosamine	0.4	0.5	0.9	0.3	-0.7	-0.9	0.7	-0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.5	0.8	1.6	1.1	0.8	1.6	1.4
Medication: Atenolol	0.4	0.5	1.5	0.4	-0.0	1.2	0.8	-0.6	0.4
Medication: Levothyroxine sodium	0.5	0.9	2.4	-0.7	0.3	0.3	1.6	-0.9	1.2
Sitting height	0.5	3.2	6.6	-2.0	-0.6	-0.7	2.1	2.6	-1.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-1.4	-0.7	0.0	0.9	-0.6	-0.8
High blood pressure (mother)	0.2	0.3	0.8	-0.9	-0.4	-0.3	-0.6	-0.4	-0.1
Body mass index (BMI)	0.3	1.5	3.5	-1.4	-0.7	-1.1	-1.9	-1.1	-0.6
Impedance of leg (left)	0.5	2.2	6.8	2.6	1.2	-0.3	1.9	0.6	1.2
Leg predicted mass (left)	0.7	3.7	9.4	-3.1	-1.8	-1.6	-0.4	0.1	-2.6
Trunk fat mass	0.6	2.5	4.5	-2.1	-1.4	-2.1	-0.8	-0.9	-1.6
Waist circumference	0.5	1.9	3.8	-0.8	-1.3	-1.7	-0.8	-1.9	-1.2
Number of incorrect matches in round	0.7	1.2	5.0	-0.4	0.7	-0.7	-1.2	2.2	0.2
Past tobacco smoking	1.0	1.9	4.2	0.0	2.0	0.5	-0.6	2.0	1.6
Alcohol usually taken with meals	0.9	1.4	3.0	1.2	1.4	-0.1	0.4	1.4	1.7
Nervous feelings	0.8	1.5	3.9	-0.9	-1.6	-0.5	-0.1	-1.1	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.0	-1.6	-1.4	-0.5	-1.1	-0.5	-2.2
Hearing difficulty/problems with background noise	0.4	0.7	2.2	1.5	0.1	-1.0	-0.2	0.8	-0.4
Hair/balding pattern: Pattern 2	1.1	1.4	3.2	-0.3	-1.5	-1.8	0.0	-1.5	-0.7
Had menopause	1.2	1.5	2.8	-1.6	-1.7	-0.4	-0.1	-1.2	-1.5
Had other major operations	0.6	0.7	1.9	0.8	-0.9	-0.8	0.3	-0.5	-1.4
Forced vital capacity (FVC)	0.3	1.2	4.5	0.2	0.2	-0.8	1.2	2.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	8.1	-0.5	0.9	2.8	0.3	2.0	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	3.3	0.8	0.2	0.5	-1.8	0.6	-0.3
Qualifications: None of the above	0.7	1.5	2.5	-1.1	-1.5	-0.8	-1.1	-1.6	-1.2
Financial difficulties in last 2 years	1.4	1.9	2.9	1.2	1.7	1.6	-0.5	1.2	1.6
Mouth/teeth dental problems	1.4	2.2	5.4	0.7	1.8	1.1	-0.1	1.7	2.3
Heart attack	1.5	2.0	3.3	-1.8	-1.8	-0.3	-1.0	-1.8	-1.0
Allergy	0.8	1.8	7.1	0.4	1.6	0.4	0.5	0.8	2.7
Pain all over the body in last month	2.0	2.2	4.0	-1.2	-2.0	-1.2	-0.6	-1.5	-1.9
Diabetes (self-reported)	0.4	0.7	3.2	-0.5	-0.1	1.8	0.2	-0.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.5	0.2	-0.2	1.4	1.0	-0.1
Medication: Ramipril	1.3	1.6	4.0	-1.1	-1.5	1.1	0.7	-2.0	-0.8
Medication: Simvastatin	1.8	2.6	5.4	-1.1	-1.8	-1.4	-1.0	-2.3	-1.6
Fluid intelligence score	0.1	0.3	0.9	-0.4	-0.2	-0.9	-0.1	-0.2	-0.7
Illnesses of siblings	0.9	1.3	5.8	-0.9	0.6	-0.0	-0.7	2.4	-0.6
Neuroticism score	0.8	1.7	2.7	-1.3	-1.5	1.0	-1.2	-1.6	-1.2
Weight	0.5	2.6	4.7	-2.2	-1.6	-1.9	-0.5	-0.6	-2.0
Impedance of arm (right)	0.3	1.5	3.5	1.0	0.7	-1.9	1.2	1.2	1.0
Arm fat percentage (right)	0.4	1.7	3.7	-1.5	-0.6	-1.9	-1.7	-0.9	-0.3
Trunk fat-free mass	0.5	3.1	8.5	-2.3	-2.0	-0.9	0.3	-0.5	-2.9
Hip circumference	0.5	2.3	6.2	-1.3	-1.2	-2.5	-1.2	-0.0	-1.8
Time employed in main current job	0.1	0.1	0.4	0.2	-0.2	0.2	0.3	-0.6	0.2
Alcohol intake versus 10 years previously	0.7	1.1	4.1	0.4	0.9	-0.9	0.8	0.1	2.0
Father’s age at death	1.2	1.7	4.3	0.4	1.2	-0.1	-2.1	1.5	1.3
Worrier / anxious feelings	1.6	3.0	6.1	-1.6	-2.5	-0.3	0.9	-2.1	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.5	-1.3	-1.8	-1.1	-0.4	-1.1	-2.1
Falls in the last year	0.2	0.2	0.6	0.1	0.1	0.6	-0.2	0.6	-0.8
Hair/balding pattern: Pattern 3	0.5	0.7	2.9	0.4	0.6	1.7	-0.4	0.3	0.9
Number of live births	0.3	0.4	1.3	0.5	0.6	-0.0	1.1	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.3	0.6	0.7	-0.2	1.1	2.1	-0.0
Pulse rate	0.6	0.9	1.7	0.9	1.2	-1.1	-0.5	1.3	0.4
Happiness	0.4	0.5	1.3	1.1	0.4	0.3	-1.1	0.3	0.0
Noisy workplace	0.4	0.5	1.4	-1.1	-0.3	0.1	0.4	-1.2	0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	-0.4	0.8	0.0	1.8	1.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.9	0.2	0.0	-1.1	1.7	0.9	-0.3
Mouth/teeth dental problems: Dentures	2.4	4.1	8.9	-1.7	-2.3	-2.4	0.4	-1.3	-3.0
Asthma	0.6	1.1	2.8	0.2	-1.1	0.0	-1.0	-1.3	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	5.1	-1.1	-0.6	-1.0	-2.3	-1.5	-0.5
Medication: Cholesterol lowering	0.3	0.4	1.8	-0.5	-0.5	0.3	0.4	-1.3	0.1
Depression (self-reported)	0.2	0.3	1.3	-0.1	0.6	0.1	-0.3	1.1	0.0
Medication: Lansoprazole	1.5	1.8	2.6	1.2	1.6	1.1	0.6	1.6	1.6
Prospective memory result	0.4	0.5	1.9	-0.3	-0.8	0.4	-0.5	0.5	-1.4
Lung cancer (father)	0.9	1.1	2.0	-1.2	-0.1	-1.4	-1.0	0.8	-1.1
Illnesses of mother	0.2	0.2	0.9	0.6	0.1	1.0	0.2	0.0	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.5	0.6	0.4	-0.7	-0.2	2.1	-0.6
Pulse wave Arterial Stiffness index	0.8	1.0	2.1	-1.5	-1.2	0.1	0.7	-1.2	-0.2
Impedance of arm (left)	0.2	1.1	1.6	1.1	0.7	-1.2	1.3	1.1	0.8
Arm fat mass (right)	0.4	1.7	3.7	-1.9	-0.8	-1.7	-1.3	-0.6	-1.0
Trunk predicted mass	0.5	2.9	8.1	-2.2	-1.9	-0.9	0.3	-0.4	-2.9
Standing height	0.6	5.5	10.6	-1.7	-1.9	-2.0	3.2	1.3	-3.2
Length of working week for main job	1.9	2.1	3.9	1.4	2.0	0.8	1.0	1.4	1.8
Exposure to tobacco smoke at home	0.8	0.9	2.3	-1.5	-0.6	0.7	-1.4	-0.5	-0.0
Breastfed as a baby	1.1	1.4	4.1	-0.1	1.1	0.0	2.0	1.2	1.2
Tense / ‘highly strung’	1.1	1.9	3.5	-1.0	-1.6	0.6	-1.8	-0.9	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	4.2	-0.6	-0.9	-0.0	-0.5	0.5	-2.0
Hair/balding pattern: Pattern 4	0.5	1.1	3.4	0.3	1.4	-0.5	-0.1	1.9	1.0
Birth weight of first child	1.5	2.7	6.0	1.0	1.8	0.2	-0.3	2.4	2.4
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.6	-0.3	-0.0	0.8	0.9	-0.6
Pulse wave reflection index	2.6	3.2	6.2	-2.2	-2.5	-0.5	0.8	-2.3	-1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.3	0.9	-0.1	0.9	-1.8	-1.1	0.1
Loud music exposure frequency	1.9	2.1	3.1	1.3	1.7	-0.8	1.1	1.6	1.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.0	-1.7	-1.4	-1.7	-0.4	-1.3	-1.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.1	-0.5	-1.0	0.1	-1.3	-2.0	-0.9
Blood clot in the leg (DVT)	0.9	1.2	2.9	-0.6	1.1	-0.3	1.7	1.4	0.7
Medication: Paracetamol	1.0	1.6	4.8	2.2	-0.1	-1.3	0.3	-1.7	0.2
Headache pain in last month	2.9	5.0	8.4	1.3	2.8	0.4	1.8	2.9	2.9
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.4	1.6	1.5	0.3	-0.9	1.9	0.8
Glaucoma (self-reported)	0.4	0.4	0.9	0.9	0.4	0.7	-0.8	0.4	0.5
Gout (self-reported)	0.5	0.7	3.0	0.6	0.3	1.7	-0.7	-0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	-0.4	0.5	-0.0	1.3	-0.7	1.1
Medication: Amlodipine	0.7	1.0	1.9	-1.3	-0.9	0.5	1.4	-0.8	-0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.0	-0.6	0.5	0.3	-0.6	-0.1
Birth weight	1.4	2.9	11.4	-0.1	1.9	1.3	0.5	0.9	3.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	-0.1	0.4	-1.0	0.6	0.9	0.4
High blood pressure (siblings)	0.9	1.3	6.1	-0.1	-1.0	-0.3	0.7	-2.5	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	3.5	0.0	-0.1	-0.8	-0.2	1.9	-0.9
Body fat percentage	0.4	1.4	3.9	-1.2	-0.7	-2.0	-1.4	-0.9	-0.6
Leg fat percentage (right)	0.3	1.2	3.4	-0.5	-0.4	-1.4	-1.8	-1.3	-0.1
Arm fat-free mass (right)	0.6	3.0	8.0	-2.4	-1.9	-0.7	-0.4	-0.7	-2.8
Exposure to tobacco smoke outside home	1.0	1.3	3.9	1.3	0.8	-0.8	-2.0	0.3	0.9
Comparative body size at age 10	1.4	4.0	11.0	-0.3	2.4	1.9	0.3	1.9	3.3
Number of full brothers	0.4	0.6	1.8	-0.3	0.7	0.9	0.4	-0.3	1.4
Worry too long after embarrassment	2.0	3.3	9.2	-1.6	-1.6	1.1	-1.5	-3.0	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.8	-0.5	0.5	-0.7	-0.2	-1.0
Wheeze or whistling in the chest in last year	0.4	0.7	2.2	0.1	-1.2	-0.2	-0.0	-1.5	-0.8
Number of children fathered	0.3	0.3	1.2	-1.1	-0.2	-0.2	0.3	0.4	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.6	1.2	0.8	-0.7	0.3	1.3	0.7
Age at first live birth	0.1	0.2	0.6	0.4	-0.3	0.1	-0.8	-0.4	-0.5
Pulse wave peak to peak time	0.7	0.9	2.0	1.3	1.1	-0.3	-0.3	1.4	0.0
Health satisfaction	1.0	1.3	3.3	-0.5	-1.4	-0.1	0.4	-1.3	-1.8
Shortness of breath walking on level ground	0.7	0.8	1.5	1.1	-0.6	0.8	-0.2	-1.0	-1.2
Qualifications: College or University degree	0.4	1.1	1.7	1.2	1.2	-0.1	1.1	1.3	0.9
Eye problems/disorders: None of the above	1.4	1.6	4.9	-0.9	-0.3	-1.8	2.2	0.2	-0.8
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.3	-1.5	-2.0	0.0	1.6	-2.1	-2.0
Emphysema/chronic bronchitis	1.3	1.5	3.0	-1.6	-1.7	0.1	-0.0	-1.1	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.4	4.1	-0.1	0.9	1.4	1.0	2.0	0.8
Neck or shoulder pain in last month	0.4	0.5	2.3	1.5	0.3	-0.7	0.1	0.4	-0.0
Medication: Blood pressure	0.8	1.5	3.1	-1.0	-1.5	-0.6	0.9	-1.8	-1.1
Angina (self-reported)	0.3	0.3	0.8	0.6	0.1	0.9	-0.8	-0.3	0.4
Migraine (self-reported)	1.2	1.5	3.9	-0.1	0.9	0.5	1.9	0.1	2.0
Medication: Ibuprofen	1.2	1.4	3.2	-1.5	-0.4	-1.4	-1.8	-0.9	-0.4
Medication: Allopurinol	0.9	1.2	5.2	0.9	0.2	2.3	-1.0	-0.5	-0.1
Medication: Omeprazole	0.6	0.7	1.0	1.0	0.9	1.0	0.7	0.6	0.9
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-1.2	-0.9	0.3	-1.5	-1.4	-0.7
Mean time to correctly identify matches	4.2	8.1	16.0	-2.1	-3.5	-1.7	-2.9	-2.0	-4.0
Heart disease (mother)	0.5	0.6	1.3	-0.7	-1.1	-0.5	-0.2	-1.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.3	-0.2	0.2	0.9	-0.2	-0.8
Whole body fat mass	0.4	1.8	3.7	-1.9	-1.1	-1.8	-1.0	-0.7	-1.2
Leg fat mass (right)	0.4	1.7	3.0	-1.7	-1.1	-1.5	-1.3	-1.0	-1.1
Arm predicted mass (right)	0.5	2.7	7.5	-2.2	-1.7	-0.4	-0.1	-0.6	-2.7
Pulse rate, automated reading	0.3	1.1	5.8	0.3	0.3	-2.4	0.1	0.3	0.4
Alcohol intake frequency.	0.5	1.2	1.9	-1.1	-1.4	-0.8	-0.4	-1.2	-1.4
Comparative height size at age 10	0.9	5.1	11.7	-3.4	-2.3	-1.6	0.3	-0.4	-3.2
Number of full sisters	0.7	0.9	1.6	1.0	1.0	0.2	-0.5	1.2	1.3
Suffer from ‘nerves’	0.2	0.3	1.0	0.3	-0.6	-0.3	0.3	0.1	-1.0
Overall health rating	0.3	0.7	2.5	-0.4	-0.2	-1.6	-1.0	-0.4	0.0
Chest pain or discomfort	0.7	1.0	2.8	1.0	0.8	1.3	0.3	-0.2	1.7
Had major operations	4.1	4.8	7.6	-2.3	-2.7	-1.5	-0.8	-2.4	-2.8
Age at last live birth	0.3	0.4	1.4	0.4	-0.5	-0.2	-0.5	-1.2	-0.6
Family relationship satisfaction	0.6	0.8	4.4	-0.2	-0.4	-0.2	-2.1	0.3	-0.4
Leg pain on walking	0.1	0.2	0.4	0.6	0.2	0.4	-0.2	0.6	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.7	-1.1	-0.3	1.3	-1.0	-0.6	0.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.9	0.3	1.1	2.2	1.0	1.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	1.0	0.4	-0.1	0.2	0.4	0.8
Medication: Aspirin	1.4	1.8	5.6	-0.6	-1.1	1.8	-0.7	-2.4	-0.6
Supplements: Vitamin C	0.8	0.9	3.2	-1.8	-0.5	-1.3	0.2	-0.5	-0.3
Knee pain experienced in last month	0.3	0.5	1.4	0.6	-0.7	1.2	-0.4	-0.6	-0.6
Hypertension (Self-reported)	2.5	6.9	14.5	-1.3	-3.3	-0.8	0.8	-3.8	-3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.6	4.2	7.6	0.9	2.5	1.5	1.5	2.8	2.5
Illnesses of father: Heart disease	0.8	1.1	4.6	0.2	-0.6	0.2	1.1	-2.1	0.2
Illnesses of siblings: Diabetes	1.3	1.6	4.9	1.0	1.4	0.6	0.4	1.1	2.2
Smoking status: Previous	0.7	1.1	2.5	0.3	-1.6	-0.8	-0.0	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.9	0.6	1.2	0.8	2.2	1.5	1.1
Whole body fat-free mass	0.6	3.4	8.5	-2.6	-1.9	-1.2	-0.1	-0.2	-2.9
Leg fat-free mass (right)	0.6	3.1	8.4	-2.9	-1.6	-1.5	-0.1	0.2	-2.4
Arm fat percentage (left)	0.4	1.5	3.1	-1.5	-0.5	-1.6	-1.8	-0.8	-0.2
Average weekly red wine intake	0.2	0.3	0.7	-0.1	-0.6	0.1	-0.0	-0.6	-0.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.6	-0.9	-1.2	0.4	-2.1	-0.6	-1.1
Mood swings	0.1	0.2	0.6	-0.6	-0.3	0.0	-0.8	0.5	-0.1
Loneliness, isolation	1.4	1.9	4.1	1.1	1.5	1.8	0.4	0.6	2.0
Long-standing illness, disability or infirmity	0.5	0.7	2.2	0.0	-0.8	-1.0	-0.7	-0.3	-1.5
Ever had bowel cancer screening	0.5	0.6	1.8	0.4	-0.7	-1.4	0.7	-0.6	-0.1
Diabetes diagnosed by doctor	0.6	0.9	3.2	0.1	0.7	1.8	0.1	0.1	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	-0.3	-0.5	0.9	0.9	-1.0	0.6
Friendships satisfaction	1.0	1.3	3.4	0.1	-0.9	-1.1	-1.8	-1.3	-0.9
Qualifications: nursing, teaching	0.5	0.8	3.5	-0.3	-0.6	-0.2	0.7	-1.9	-0.2
Commuting to job workplace: Walk	0.5	0.5	2.2	0.4	0.3	-0.5	1.5	0.6	0.1
Eye problems/disorders: Cataract	0.5	0.5	1.7	0.3	0.0	1.3	-1.1	-0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.3	2.5	1.5	0.5	2.0	1.0	1.3
Medication for cholesterol	0.2	0.3	0.8	-0.6	-0.1	0.1	0.8	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.2	-0.3	-1.4	-1.3	-1.3	-1.0	-2.1
Back pain experienced in last month	0.4	0.6	1.6	-0.7	-0.8	-1.3	0.2	-0.4	-0.7
Mineral and other dietary supplements	1.4	1.9	3.4	0.9	1.8	1.6	-0.2	1.2	1.8
Breast cancer (self-reported)	2.9	3.4	7.5	1.6	2.3	-0.6	1.4	1.7	2.7
Asthma (self-reported)	0.6	1.2	3.4	0.2	-1.1	-0.7	-1.0	-0.9	-1.9
Osteoporosis (self-reported)	1.8	2.2	6.7	0.5	1.0	-1.3	2.6	1.6	1.1
Osteoarthritis (self-reported)	0.4	0.5	2.4	-0.3	-0.3	0.4	-1.5	-0.5	0.2
Medication: Aspirin	1.0	1.3	3.1	-0.5	-0.8	1.6	-1.0	-1.8	-0.5
Medication: Gliclazide	0.2	0.2	0.4	-0.1	0.3	0.4	-0.7	0.2	0.6
Illnesses of father: None of the above (group 1)	1.0	1.3	3.4	0.4	1.3	0.8	-0.4	1.8	1.2
Smoking status: Current	0.4	0.6	1.3	-0.4	-0.4	1.2	1.0	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.9	1.4	0.1	-1.2	-0.1	0.3	0.1
Whole body water mass	0.5	3.1	7.4	-2.6	-1.8	-1.1	-0.0	-0.2	-2.7
Leg predicted mass (right)	0.6	3.1	8.4	-2.9	-1.6	-1.5	-0.0	0.2	-2.4
Arm fat mass (left)	0.4	1.6	3.3	-1.8	-0.8	-1.5	-1.4	-0.7	-1.0
Number of self-reported non-cancer illnesses	0.7	1.2	1.9	0.2	-0.9	-1.1	1.3	-1.2	-1.4
Average weekly champagne plus white wine intake	0.4	0.6	2.1	0.2	-0.6	-0.6	-0.7	1.4	-0.4
Miserableness	0.3	0.5	0.9	-0.9	-0.9	0.5	-0.5	-0.4	-0.9
Guilty feelings	0.5	0.7	1.6	-1.3	-0.3	1.2	-0.0	-1.0	-0.0
Wears glasses or contact lenses	1.0	1.2	3.6	-0.4	-1.4	0.4	1.1	-1.9	-0.3
Ever taken oral contraceptive pill	0.1	0.1	0.6	-0.3	-0.1	0.8	-0.3	-0.0	0.2
Hearing aid user	1.2	1.4	3.5	0.9	1.5	1.0	0.6	0.7	1.9
Mother’s age at death	1.8	2.3	4.0	-1.1	-2.0	-1.1	-1.4	-1.2	-2.0
Financial situation satisfaction	2.1	2.6	5.8	1.1	1.7	1.5	-1.6	1.0	2.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.6	0.8	0.7	0.5	0.7	0.3	0.6
Commuting to job workplace: Public transport	0.0	0.1	0.2	0.3	0.0	0.2	0.1	-0.2	-0.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	0.9	0.5	1.5	-0.9	0.5	0.3
Medication: Blood pressure	0.6	1.1	2.9	0.1	-0.9	0.3	-1.2	-1.2	-1.7
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.8	1.2	-0.9	-1.5	-1.7	-0.5	-1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	-0.3	-1.1	-0.5	-1.0	-1.1	-1.1
High cholesterol (Self-reported)	0.5	0.9	3.9	0.0	-0.6	-0.8	-0.2	-2.0	-0.5
Medication: Bendroflumethiazide	0.6	0.9	2.5	0.7	-0.9	-0.3	-0.6	-1.6	-1.1
Medication: Paracetamol	1.0	1.5	5.2	2.3	0.6	-1.7	0.1	-0.6	0.4
Medication: Lisinopril	1.3	1.7	3.8	-1.1	-1.2	-2.0	-1.0	-0.4	-1.7
Medication: Atorvastatin	0.3	0.4	1.2	-0.4	0.2	1.1	0.2	-0.6	0.8
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.8	-0.1	0.4	-0.4	0.6	-1.0
Alcohol drinker status: Never	0.2	0.2	0.7	0.6	-0.0	0.4	-0.2	0.4	-0.8
Ever smoked	0.6	1.1	2.7	-0.4	-1.7	0.1	0.7	-1.4	-1.2
Basal metabolic rate	0.6	3.1	7.1	-2.6	-1.8	-1.3	-0.3	-0.2	-2.7
Leg fat percentage (left)	0.3	1.0	2.7	-0.3	-0.3	-1.4	-1.6	-1.2	-0.0
Arm fat-free mass (left)	0.4	2.0	5.1	-1.9	-1.4	-1.0	-0.2	-0.6	-2.3
Number of operations (self-reported)	2.4	3.6	8.6	-1.4	-1.7	-2.9	-1.3	-1.2	-2.2
Average weekly beer plus cider intake	0.4	0.6	1.8	-0.1	-0.5	-0.7	-0.8	-1.4	-0.4
Irritability	1.0	1.7	4.8	-0.7	-1.0	0.6	-2.2	-1.6	-1.2
Risk taking	0.6	0.9	3.8	0.6	0.0	1.9	1.0	0.3	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	-0.7	-1.2	0.7	-0.2	-0.7	-1.5
Fractured/broken bones in last 5 years	0.7	0.8	1.8	0.5	-0.0	-0.7	-1.3	-0.9	-1.3
Age started oral contraceptive pill	0.8	1.0	4.4	0.2	-0.2	-2.1	0.9	0.4	-0.7
Diastolic blood pressure, automated reading	0.5	1.4	3.7	-1.0	-1.4	-0.9	-0.2	-0.9	-1.9
Ever depressed for a whole week	0.6	0.8	2.4	0.1	-0.5	0.1	-1.6	-0.1	-1.3
Unable to work because of sickness or disability	0.8	1.0	2.9	1.3	1.0	-0.4	0.1	1.7	0.4
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.4	0.4	-0.7	-0.5	0.8	-0.3
Myopia	0.5	0.7	2.4	-0.1	-0.9	-1.6	0.7	-0.5	-0.7
Vascular/heart problems diagnosed by doctor	2.1	5.8	14.1	0.9	3.1	0.7	-0.2	3.8	3.1
Cholesterol lowering medication	0.8	1.2	2.6	-0.1	-0.8	-0.4	-1.6	-1.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.9	0.8	0.7	1.0	0.3	0.9
Pain experienced in last month	0.1	0.2	0.9	0.2	0.3	0.4	0.9	-0.3	0.4
Supplements: Calcium	1.4	1.5	5.5	-1.1	-0.2	1.4	2.3	0.6	0.2
Basal cell carcinoma (self-reported)	0.7	0.8	3.4	-1.0	0.0	0.5	1.8	0.1	0.0
Heart attack/myocardial infarction (self-reported)	1.9	2.5	4.2	-2.1	-2.0	-0.4	-1.1	-2.0	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.7	-0.5	1.1	-0.1	1.3	1.2	0.9
Heart disease (siblings)	0.5	0.7	1.7	0.1	-1.1	0.1	1.1	-1.3	0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.6	-0.1	0.2	0.4	-0.5	-0.0
Pack years of smoking	0.6	0.8	2.1	-1.4	-0.3	-0.8	1.5	0.2	-0.4
Impedance of whole body	0.3	1.7	3.5	1.9	0.8	-0.9	1.8	0.8	0.9
Leg fat mass (left)	0.4	1.7	2.9	-1.7	-1.1	-1.6	-1.2	-1.0	-1.1
Arm predicted mass (left)	0.5	2.5	6.1	-2.2	-1.6	-1.2	-0.2	-0.5	-2.5