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chr1:76,292,728-79,699,821

Best TWAS P=2.35e-16 · Best GWAS P=4.27e-47 conditioned to 3.85e-25

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Coronary	PIGK	0.22	0.00	lasso	8	-0.01	9.0e-01	5.8	-6.8	1.5e-11	-0.10	0.08	0.07	TRUE
2	GTEx	Cells EBV-transformed lymphocytes	NEXN	0.23	0.10	lasso	3	0.08	1.4e-03	-7.8	-7.9	2.1e-15	-0.13	0.21	0.04	FALSE
3	GTEx	Cells Transformed fibroblasts	PTGFR	0.12	0.04	enet	17	0.04	4.7e-04	2.4	-5.2	1.9e-07	-0.26	0.97	0.00	FALSE
4	GTEx	Lung	GIPC2	0.15	0.09	enet	17	0.12	2.5e-09	-7.5	8.2	2.4e-16	0.19	1.00	0.00	TRUE
5	GTEx	Nerve Tibial	DNAJB4	0.08	0.07	lasso	3	0.07	1.3e-05	-6.7	-6.7	2.5e-11	-0.14	0.82	0.01	FALSE
6	GTEx	Pancreas	GIPC2	0.41	0.13	enet	29	0.14	1.1e-06	-6.5	6.8	1.4e-11	0.31	0.65	0.10	FALSE
7	GTEx	Skin Sun Exposed Lower leg	DNAJB4	0.07	0.05	lasso	5	0.05	6.5e-05	-6.7	-6.2	5.3e-10	-0.11	0.60	0.01	FALSE
8	GTEx	Spleen	GIPC2	0.43	0.07	enet	19	0.22	2.9e-06	-7.0	7.7	1.4e-14	0.22	0.83	0.02	FALSE
9	METSIM	Adipose	DNAJB4	0.04	0.04	lasso	4	0.03	2.1e-05	-5.0	-5.7	9.7e-09	-0.26	0.70	0.01	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	DNAJB4	0.08	0.09	lasso	2	0.09	1.3e-11	-6.5	-6.5	7.8e-11	-0.18	1.00	0.00	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	FAM73A	0.09	0.04	enet	19	0.06	9.6e-09	-2.0	5.7	1.1e-08	0.33	0.99	0.01	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DNAJB4	0.05	0.03	lasso	3	0.02	3.3e-03	-6.5	-7.3	2.7e-13	-0.20	0.00	0.98	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	GIPC2	0.02	0.02	lasso	2	0.02	8.3e-05	-6.5	6.7	2.7e-11	0.24	0.56	0.02	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	PTGFR	0.02	0.01	blup	45	0.02	2.2e-04	1.8	5.3	1.3e-07	0.24	0.28	0.32	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	GIPC2	0.04	0.01	blup	65	0.00	2.5e-01	-6.8	8.0	1.6e-15	0.28	0.07	0.06	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GIPC2	0.10	0.06	enet	13	0.06	1.5e-07	-8.1	6.6	3.8e-11	0.37	0.96	0.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM73A	0.14	0.02	enet	14	0.06	3.8e-04	3.4	5.8	6.1e-09	0.11	0.02	0.04	TRUE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNAJB4	0.08	0.07	lasso	1	0.06	9.3e-08	-6.5	-6.5	1.1e-10	-0.19	0.18	0.81	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	GIPC2	0.02	0.02	lasso	3	0.02	1.0e-03	-6.9	7.0	2.0e-12	0.22	0.37	0.02	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJB4	0.04	0.04	lasso	2	0.04	1.2e-05	7.1	-7.2	7.3e-13	-0.45	0.01	0.97	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	GIPC2	0.10	0.11	blup	64	0.13	1.1e-13	-7.2	6.2	6.1e-10	0.13	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DNAJB4	0.24	0.14	lasso	1	0.11	1.1e-04	-6.5	-6.5	1.1e-10	-0.19	0.01	0.89	FALSE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PTGFR	0.12	0.05	blup	45	0.07	1.9e-03	7.6	5.6	1.8e-08	0.28	0.01	0.63	TRUE
24	The Cancer Genome Atlas	Thyroid Carcinoma	GIPC2	0.07	0.05	blup	64	0.06	1.5e-06	-6.9	7.9	2.4e-15	0.28	0.67	0.02	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	ST6GALNAC3	0.20	0.18	enet	10	0.18	6.8e-17	5.0	5.8	6.0e-09	0.06	0.78	0.22	TRUE