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chr4:121,982,122-124,538,705

Best TWAS P=3.99e-49 · Best GWAS P=7.51e-44 conditioned to 3.19e-185

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BBS7	0.19	0.21	bslmm	423	0.23	1.8e-27	-12.740	-13.7	8.2e-43	-0.70	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KIAA1109	0.09	0.08	bslmm	390	0.08	8.9e-10	5.360	-6.7	2.5e-11	-0.18	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	lasso	3	0.02	6.5e-04	7.954	8.2	3.8e-16	-0.02	0.72	0.03	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TMEM155	0.06	0.05	lasso	3	0.02	5.5e-04	-11.406	-10.8	2.0e-27	-0.67	0.43	0.36	FALSE
5	GTEx	Adipose Subcutaneous	EXOSC9	0.07	0.00	lasso	2	0.00	4.5e-01	-10.543	10.5	1.2e-25	0.51	0.06	0.16	FALSE
6	GTEx	Artery Aorta	KIAA1109	0.11	0.00	lasso	7	0.01	5.1e-02	5.258	-7.9	3.2e-15	-0.42	0.05	0.64	FALSE
7	GTEx	Artery Tibial	FGF2	0.18	0.05	lasso	3	0.02	1.3e-02	6.290	6.2	4.9e-10	-0.05	0.08	0.14	TRUE
8	GTEx	Artery Tibial	KIAA1109	0.16	0.07	lasso	6	0.05	5.1e-05	5.403	-5.5	4.2e-08	-0.15	0.61	0.03	FALSE
9	GTEx	Artery Tibial	NUDT6	0.08	0.08	lasso	5	0.05	5.6e-05	7.864	8.3	8.2e-17	-0.02	0.65	0.08	FALSE
10	GTEx	Brain Cerebellar Hemisphere	BBS7	0.27	0.05	lasso	3	0.08	4.7e-03	-10.519	-9.2	2.3e-20	-0.37	0.12	0.07	FALSE
11	GTEx	Brain Cerebellar Hemisphere	NUDT6	0.32	0.07	enet	16	0.16	5.0e-05	-7.956	-7.8	7.3e-15	0.04	0.19	0.14	TRUE
12	GTEx	Brain Cerebellum	BBS7	0.20	-0.01	enet	24	0.01	2.2e-01	-10.508	-11.5	1.3e-30	-0.60	0.06	0.76	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	KIAA1109	0.22	0.07	lasso	7	0.03	5.9e-02	5.403	-5.8	6.6e-09	-0.20	0.07	0.12	FALSE
14	GTEx	Breast Mammary Tissue	NUDT6	0.25	0.10	lasso	3	0.08	4.2e-05	8.715	8.9	6.9e-19	0.03	0.18	0.75	TRUE
15	GTEx	Breast Mammary Tissue (Male)	NUDT6	0.29	0.00	lasso	6	0.00	3.5e-01	7.781	8.5	1.8e-17	0.04	0.04	0.36	TRUE
16	GTEx	Breast Mammary Tissue (Female)	NUDT6	0.30	-0.01	enet	30	0.00	2.6e-01	9.422	6.9	6.0e-12	0.02	0.04	0.28	TRUE
17	GTEx	Cells EBV-transformed lymphocytes	EXOSC9	0.29	0.17	lasso	7	0.16	6.6e-06	13.557	14.2	5.0e-46	0.96	0.01	0.99	FALSE
18	GTEx	Cells Transformed fibroblasts	BBS7	0.16	0.09	lasso	7	0.16	2.9e-12	-12.691	-14.7	4.0e-49	-0.84	0.05	0.95	TRUE
19	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	-2.844	9.7	5.0e-22	0.03	0.05	0.51	TRUE
20	GTEx	Muscle Skeletal	NUDT6	0.15	0.12	lasso	3	0.11	1.1e-10	7.954	8.0	1.9e-15	-0.02	1.00	0.00	FALSE
21	GTEx	Muscle Skeletal	RP11-170N16.3	0.07	0.07	lasso	3	0.06	8.8e-07	6.783	7.9	3.8e-15	-0.02	0.27	0.72	FALSE
22	GTEx	Nerve Tibial	NUDT6	0.11	0.08	lasso	3	0.05	2.1e-04	7.493	7.5	6.9e-14	-0.01	0.80	0.02	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	NUDT6	0.07	0.02	lasso	6	0.03	1.5e-02	7.665	8.3	7.2e-17	0.02	0.14	0.71	TRUE
24	GTEx	Skin Sun Exposed Lower leg	NUDT6	0.11	0.08	lasso	3	0.08	6.2e-07	7.781	7.9	2.2e-15	0.01	0.95	0.02	TRUE
25	GTEx	Testis	EXOSC9	0.17	0.07	lasso	8	0.10	2.5e-05	-10.509	13.9	6.5e-44	0.78	0.61	0.18	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	EXOSC9	0.05	0.02	lasso	7	0.02	5.3e-04	11.865	12.2	2.5e-34	0.74	0.06	0.90	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	TMEM155	0.05	0.01	bslmm	422	0.01	1.7e-02	-10.495	-7.4	1.2e-13	-0.39	0.23	0.15	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	enet	9	0.03	2.0e-04	7.801	6.2	5.3e-10	-0.02	0.65	0.11	TRUE
29	YFS	Blood	EXOSC9	0.06	0.09	bslmm	401	0.09	7.0e-28	13.886	14.0	2.5e-44	0.97	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC9	0.03	0.04	enet	9	0.04	2.8e-08	13.303	14.5	1.9e-47	0.94	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1109	0.03	0.03	lasso	1	0.02	1.2e-05	5.403	-5.4	6.5e-08	-0.14	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUDT6	0.02	0.02	lasso	4	0.01	5.4e-03	7.865	7.7	1.1e-14	-0.02	0.13	0.14	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCNA2	0.11	-0.01	enet	14	0.02	4.4e-02	-0.005	7.1	1.0e-12	-0.02	0.01	0.04	FALSE
34	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRPC3	0.15	0.03	enet	11	0.13	8.7e-07	-1.571	-5.8	5.0e-09	-0.12	0.12	0.04	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	BBS7	0.05	0.00	blup	47	0.02	1.9e-02	13.305	-13.1	4.4e-39	-0.87	0.01	0.69	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BBS7	0.04	0.02	blup	47	0.03	1.3e-04	-10.519	-10.1	3.9e-24	-0.46	0.54	0.09	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNA2	0.03	0.01	blup	34	0.02	1.5e-03	-12.728	14.4	6.8e-47	0.70	0.05	0.71	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA1109	0.05	0.05	enet	8	0.04	1.3e-05	5.403	-5.9	3.3e-09	-0.14	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BBS7	0.04	0.04	lasso	2	0.03	6.1e-04	-12.740	-12.6	3.7e-36	-0.55	0.60	0.14	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FGF2	0.06	0.04	blup	65	0.05	4.4e-06	10.296	10.3	5.6e-25	-0.02	0.01	0.99	TRUE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA1109	0.06	0.05	lasso	2	0.03	7.1e-05	5.403	-5.3	9.0e-08	-0.15	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	NUDT6	0.05	0.06	lasso	2	0.05	2.0e-06	7.864	5.4	6.0e-08	-0.04	0.81	0.08	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	BBS7	0.03	0.01	lasso	2	0.02	2.7e-03	-10.495	-7.1	1.2e-12	-0.23	0.11	0.02	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EXOSC9	0.03	0.02	lasso	2	0.02	1.0e-03	13.134	13.9	6.8e-44	0.92	0.00	0.95	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	EXOSC9	0.03	0.00	blup	43	0.02	8.0e-03	13.303	8.4	4.7e-17	0.75	0.01	0.49	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDT6	0.10	0.07	lasso	6	0.07	1.0e-07	7.864	7.5	9.3e-14	-0.03	0.98	0.02	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC9	0.04	0.05	lasso	2	0.04	7.1e-05	13.303	14.5	1.1e-47	0.92	0.02	0.97	FALSE