Best TWAS P=1.24e-20 · Best GWAS P=8.16e-24 conditioned to 4.06e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CTBS | 0.16 | 0.11 | lasso | 9 | 0.15 | 3.8e-18 | -3.8 | 5.5 | 3.4e-08 | 0.01 | 0.39 | 0.28 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNHIT6 | 0.05 | 0.01 | bslmm | 552 | 0.01 | 1.9e-02 | 9.9 | -8.8 | 1.9e-18 | 0.55 | 0.01 | 0.95 | FALSE |
| 3 | GTEx | Liver | DDAH1 | 0.36 | 0.42 | lasso | 6 | 0.43 | 2.8e-13 | -5.6 | 6.1 | 1.2e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Lung | C1orf52 | 0.17 | 0.08 | lasso | 6 | 0.04 | 4.9e-04 | 4.5 | 6.0 | 2.7e-09 | -0.09 | 0.81 | 0.10 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ZNHIT6 | 0.11 | 0.12 | enet | 15 | 0.14 | 1.5e-17 | 9.9 | -8.8 | 1.3e-18 | 0.71 | 0.01 | 0.99 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | DDAH1 | 0.03 | 0.03 | lasso | 3 | 0.02 | 1.5e-03 | -5.6 | -5.6 | 2.1e-08 | -0.04 | 0.65 | 0.01 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | C1orf52 | 0.05 | 0.02 | blup | 564 | 0.03 | 9.5e-05 | 3.6 | 6.3 | 2.2e-10 | 0.00 | 0.25 | 0.62 | TRUE |
| 8 | YFS | Blood | ODF2L | 0.04 | 0.04 | enet | 18 | 0.04 | 1.8e-12 | 6.2 | -7.0 | 1.8e-12 | 0.10 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | COL24A1 | 0.29 | 0.00 | blup | 264 | 0.06 | 5.5e-03 | 2.9 | -9.3 | 1.2e-20 | 0.09 | 0.06 | 0.05 | TRUE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC339524 | 0.02 | 0.00 | blup | 107 | 0.02 | 4.6e-03 | -3.9 | 5.5 | 2.9e-08 | 0.05 | 0.01 | 0.26 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | COL24A1 | 0.21 | 0.17 | enet | 5 | 0.19 | 2.4e-18 | 4.6 | -5.2 | 2.6e-07 | 0.11 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | SPATA1 | 0.07 | 0.07 | blup | 73 | 0.08 | 6.7e-08 | -4.5 | 5.1 | 2.9e-07 | 0.01 | 0.02 | 0.96 | FALSE |