Best TWAS P=3.8e-37 · Best GWAS P=2.05e-41 conditioned to 6.4e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C5orf42 | 0.04 | 0.03 | lasso | 4 | 0.04 | 1.2e-05 | -6.40 | 7.8 | 7.7e-15 | -0.65 | 0.41 | 0.46 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | NADK2 | 0.24 | 0.02 | enet | 14 | 0.10 | 4.9e-04 | -5.09 | -5.9 | 4.7e-09 | 0.09 | 0.19 | 0.04 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | WDR70 | 0.06 | 0.03 | lasso | 8 | 0.03 | 3.5e-03 | -9.29 | 9.6 | 6.7e-22 | -0.72 | 0.40 | 0.40 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SPEF2 | 0.26 | 0.01 | enet | 56 | 0.04 | 2.6e-04 | 1.30 | 6.7 | 2.8e-11 | 0.01 | 0.39 | 0.04 | TRUE |
| 5 | GTEx | Esophagus Muscularis | NADK2 | 0.14 | 0.09 | lasso | 3 | 0.07 | 6.7e-05 | -5.09 | 5.4 | 6.8e-08 | -0.03 | 0.70 | 0.05 | FALSE |
| 6 | GTEx | Nerve Tibial | WDR70 | 0.17 | 0.07 | lasso | 3 | 0.05 | 1.4e-04 | 8.95 | 8.6 | 7.4e-18 | -0.43 | 0.40 | 0.03 | FALSE |
| 7 | GTEx | Whole Blood | NUP155 | 0.05 | 0.01 | enet | 14 | 0.04 | 1.1e-04 | -13.48 | 8.3 | 1.4e-16 | -0.61 | 0.01 | 0.94 | FALSE |
| 8 | GTEx | Whole Blood | C5orf42 | 0.07 | 0.00 | enet | 16 | 0.01 | 1.8e-02 | -13.48 | 8.7 | 3.8e-18 | -0.68 | 0.01 | 0.87 | FALSE |
| 9 | METSIM | Adipose | SPEF2 | 0.06 | 0.01 | blup | 522 | 0.03 | 4.0e-05 | -0.77 | 5.4 | 5.0e-08 | 0.00 | 0.74 | 0.03 | FALSE |
| 10 | YFS | Blood | IL7R | 0.03 | 0.01 | bslmm | 467 | 0.01 | 8.1e-05 | -3.82 | -6.2 | 4.4e-10 | -0.04 | 0.82 | 0.05 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UGT3A2 | 0.04 | 0.00 | blup | 52 | 0.01 | 4.9e-02 | 4.58 | -6.5 | 8.8e-11 | -0.02 | 0.01 | 0.45 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UGT3A2 | 0.06 | 0.02 | blup | 52 | 0.05 | 9.7e-10 | -5.65 | -5.3 | 1.1e-07 | -0.05 | 0.19 | 0.81 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C5orf42 | 0.04 | 0.05 | lasso | 3 | 0.04 | 1.1e-03 | -12.99 | 12.7 | 3.8e-37 | -0.92 | 0.00 | 0.95 | TRUE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | UGT3A2 | 0.04 | 0.05 | enet | 3 | 0.03 | 2.2e-03 | -4.93 | -5.5 | 4.8e-08 | 0.02 | 0.03 | 0.77 | FALSE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | UGT3A2 | 0.17 | 0.06 | blup | 52 | 0.08 | 2.8e-04 | 4.53 | -5.2 | 1.9e-07 | -0.02 | 0.02 | 0.79 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UGT3A2 | 0.06 | 0.04 | blup | 52 | 0.05 | 1.2e-05 | -5.38 | -6.4 | 1.2e-10 | 0.02 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Rectum Adenocarcinoma | C5orf42 | 0.75 | -0.01 | blup | 40 | 0.03 | 7.2e-02 | -9.49 | 8.5 | 2.7e-17 | -0.58 | 0.01 | 0.21 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | UGT3A2 | 0.05 | 0.00 | blup | 52 | 0.02 | 3.4e-03 | -2.98 | -5.8 | 6.4e-09 | -0.02 | 0.02 | 0.25 | FALSE |