Hub : Genes

C5orf22

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0310	6.6e-03	0.000	0.019	-0.002	0.016	-0.001	3.6e-01	2.1e-03	8.5e-01	3.7e-03	4.7e-01
2	GTEx	Adipose Subcutaneous	0.1780	0.0450	7.3e-05	0.077	NA	0.037	NA	0.069	6.8e-07	NA	4.7e-04	NA	2.7e-06
3	GTEx	Artery Aorta	0.2140	0.0650	1.1e-03	0.115	NA	0.056	NA	0.083	6.6e-07	NA	4.9e-04	NA	2.4e-05
4	GTEx	Artery Tibial	0.1073	0.0386	6.2e-03	0.106	NA	0.088	NA	0.095	1.1e-08	NA	2.1e-07	NA	7.0e-08
5	GTEx	Muscle Skeletal	0.0869	0.0345	6.6e-03	0.002	NA	-0.002	NA	0.000	2.0e-01	NA	5.6e-01	NA	3.5e-01
6	METSIM	Adipose	0.1225	0.0258	2.8e-09	0.091	0.068	0.109	0.105	0.108	1.5e-13	2.4e-10	6.4e-16	2.3e-15	6.7e-16
7	NTR	Blood	0.0333	0.0106	3.9e-04	0.001	0.005	0.003	0.005	0.003	1.6e-01	5.5e-03	2.4e-02	7.1e-03	4.3e-02
8	ROSMAP	Brain Pre-frontal Cortex	0.0881	0.0334	5.7e-03	0.064	0.014	0.053	0.055	0.057	1.3e-08	5.3e-03	2.1e-07	1.2e-07	8.1e-08
9	TCGA	Brain Lower Grade Glioma	0.0874	0.0318	3.1e-07	0.031	0.056	0.052	NA	0.047	1.7e-04	6.1e-07	1.3e-06	NA	3.9e-06
10	TCGA	Thyroid Carcinoma	0.1470	0.0430	3.2e-09	0.092	0.094	0.081	NA	0.073	3.0e-09	1.9e-09	2.7e-08	NA	1.2e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.9	3.1	13.5	-0.9	-1.6	-1.4	-1.5	-1.7	-0.2	-3.7	0.6	-1.8	-1.7
Bipolar Disorder or Schizophrenia	0.8	2.0	5.9	-1.2	-1.7	-1.0	-1.1	-0.5	-0.6	-2.4	0.6	-2.1	-1.6
Depressed Affect (Nagel 2018)	0.7	1.4	6.5	-0.0	-1.2	-1.2	-1.2	-1.2	-0.6	-2.5	-0.5	-0.9	-0.8
Depression (Nagel 2018)	1.6	2.3	4.0	-0.2	-2.0	-1.9	-1.9	-1.5	-1.3	-2.0	-0.6	-1.1	-1.7
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.1	1.0	1.1	1.1	1.1	0.9	1.8	0.9	-1.0	0.6	0.6
Neuroticism (Nagel 2018)	0.8	1.9	9.2	0.1	-1.2	-1.1	-1.1	-1.9	-0.6	-3.0	-0.2	-0.6	-1.4
Schizophrenia (2018)	0.3	0.5	1.9	-0.7	-0.8	-0.2	-0.2	0.9	0.0	-0.1	1.4	-1.2	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.7	3.9	0.8	0.3	0.7	0.7	2.0	0.0	0.3	-0.7	0.8	-0.1
Worry (Nagel 2018)	0.4	0.9	6.4	0.0	-0.2	-0.3	-0.3	-2.5	0.0	-0.8	-0.1	0.8	-0.8
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	0.6	0.7	0.7	0.6	1.2	-0.2	-0.5	-1.4	0.7	-0.9
Alzheimer’s Disease (in father)	2.4	2.6	6.3	-0.2	2.5	2.3	2.3	1.5	1.1	0.6	1.2	1.7	0.8
Alzheimer’s Disease (including proxy)	1.5	2.2	5.6	0.3	2.4	2.2	2.1	1.9	0.6	0.3	-0.3	1.6	-0.4
Crohns Disease (2017)	0.6	1.4	3.0	1.7	0.4	0.3	0.4	1.0	-1.7	1.4	-1.3	0.5	-1.5
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	0.8	-1.0	-0.9	-0.9	-0.2	-1.2	0.4	0.6	0.3	-1.1
Ulcerative Colitis (UC)	1.5	2.8	7.2	-0.8	-2.4	-2.3	-2.3	-1.3	-0.3	-1.1	2.7	-0.7	-0.1
Major Depression (MDD)	0.9	1.1	2.3	-0.3	-1.4	-1.2	-1.3	-0.2	-0.4	-1.5	1.5	-0.8	-0.6
Reaction Time	0.4	0.7	4.5	0.9	-0.8	-0.8	-0.7	2.1	0.3	-0.2	0.1	0.4	-0.0
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.1	1.2	1.5	1.4	1.5	0.4	1.5	2.2	-0.4	1.5	0.7
Breast Cancer	0.6	1.4	7.0	-0.8	1.7	1.0	1.0	0.5	-0.1	2.6	0.9	0.8	0.5
Ovarian Cancer	0.5	0.6	2.2	-1.2	0.8	0.9	0.8	-0.4	0.1	1.5	0.4	-0.0	0.5
Prostate Cancer	0.6	0.8	3.2	-0.5	-0.1	-0.3	-0.4	1.0	-0.3	1.6	-1.8	0.6	-0.5
Age at First Birth	0.9	1.4	5.8	0.6	-1.2	-1.4	-1.4	0.9	-0.4	0.1	-2.4	-0.3	-0.9
Bipolar Disorder (2011)	0.5	0.5	2.5	-0.1	-0.4	-0.3	-0.3	-1.6	-0.5	-0.0	-0.1	0.8	-1.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	0.7	1.4	1.2	1.2	0.4	-0.1	-0.1	-1.0	1.3	0.3
Coronary Artery Disease (CAD)	0.3	0.3	1.6	0.5	-0.4	-0.1	-0.2	0.7	-0.0	-0.0	-0.8	-1.3	-0.1
Crohns Disease (2012)	0.3	0.5	1.5	0.4	0.4	0.3	0.3	-0.4	-1.0	1.2	-0.6	-0.5	-1.1
Mean Putamen Volume	0.4	0.4	0.9	0.7	0.4	1.0	1.0	0.9	-0.2	-0.3	-0.7	-0.1	-0.3
Fasting Glucose	0.7	0.8	1.2	0.2	-1.0	-1.0	-1.0	-1.0	-1.1	-1.1	-0.2	-0.4	-1.1
HbA1C	0.5	0.6	1.5	0.5	-0.9	-0.7	-0.7	-0.7	-1.2	-0.9	-0.5	-0.6	-0.8
HDL Cholesterol	0.3	0.4	3.1	-0.0	-0.3	-0.5	-0.4	-1.8	0.1	0.1	-0.3	-0.6	-0.7
LDL Cholesterol	0.6	1.0	2.9	-0.7	1.1	1.3	1.2	0.6	0.1	1.7	1.1	0.2	0.9
Lupus	0.5	0.8	2.3	0.1	-1.1	-1.5	-1.5	0.2	-0.2	-0.6	0.9	-1.1	-0.2
Neuroticism (2016)	0.8	1.1	4.8	-0.4	-1.4	-1.0	-0.9	0.4	-0.2	-2.2	-0.7	-0.7	-1.0
Primary Biliary Cirrhosis	0.8	1.1	2.7	-1.6	-1.2	-0.8	-0.9	-0.7	-0.8	-1.0	1.1	-1.4	-0.0
Rheumatoid Arthritis	1.2	1.7	5.4	-1.4	-0.6	-0.4	-0.5	-0.8	-1.2	-0.9	-2.3	0.3	-2.3
Schizophrenia (2014)	0.3	0.7	1.3	-1.0	-1.1	-0.9	-0.9	0.1	-0.6	-0.5	1.1	-0.8	-0.9
Triglycerides	0.2	0.4	2.3	-0.4	0.1	0.5	0.4	1.5	-0.5	0.3	-0.6	0.1	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	-1.2	-0.0	0.4	0.4	0.6	-1.1	0.1	-1.0	-1.3	-1.3
Ulcerative Colitis	1.9	2.7	5.2	-0.8	-2.3	-2.2	-2.2	-2.0	-0.1	-2.1	1.5	-0.5	-0.7
Blood Eosinophil Count	0.0	0.4	1.0	0.5	-0.1	0.2	0.2	0.9	0.5	-1.0	0.9	-0.0	0.5
Blood Platelet Count	0.2	2.6	6.2	-1.1	-1.9	-1.6	-1.6	0.9	-1.0	-2.4	0.8	-2.5	-1.5
Blood Red Count	0.1	1.1	2.5	1.6	1.1	1.4	1.3	-0.4	1.2	1.0	-0.8	0.1	0.8
Blood White Count	0.1	0.7	3.4	0.5	0.1	0.4	0.4	-1.5	-0.7	-1.9	-0.6	-0.1	-0.6
Heel T-Score	0.3	2.6	18.4	-4.3	-1.2	-1.4	-1.4	-0.3	-0.3	-0.5	-0.7	-0.2	-0.8
BMI	0.2	0.9	3.0	0.4	1.0	1.0	1.0	0.2	1.3	0.0	-0.0	1.2	1.7
Height	0.4	8.0	31.4	2.5	3.3	3.3	3.3	-2.5	0.3	0.4	-1.5	5.6	-1.0
Waist Hip Ratio (WHR)	0.2	0.9	2.3	0.9	-0.1	-0.7	-0.7	-1.2	-1.5	-0.9	-0.6	0.7	-1.3
Systolic Blood Pressure	0.2	0.9	2.2	1.5	-0.3	-0.7	-0.7	1.1	-0.2	-0.0	1.4	1.4	0.5
Smoking Status	0.9	2.0	7.3	-0.3	2.0	2.0	1.9	0.7	-0.4	-0.6	0.4	2.7	0.2
Allergy or Eczema	0.3	0.7	2.2	-0.1	0.4	0.6	0.6	0.7	1.4	-0.3	1.5	-0.8	0.9
Cardiovascular Disease	0.3	0.9	2.6	1.1	-0.1	-0.3	-0.2	1.4	0.8	-0.6	1.6	1.0	0.9
Hypothyroidism (self reported)	0.4	0.9	2.7	-0.8	-1.5	-1.1	-1.2	-0.7	-0.5	-0.5	-0.2	-1.6	0.3
Respiratory disease	0.2	0.3	0.8	-0.1	-0.9	-0.9	-0.9	0.2	0.5	0.2	0.0	0.1	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.1	0.4	-0.1	-0.4	-0.4	0.8	-0.5	-1.4	0.2	0.3	1.0
Lung FEV1/FVC ratio	0.3	1.6	5.2	2.3	-0.5	-0.6	-0.6	2.0	1.0	-1.4	1.7	-0.0	0.7
Lung FVC	0.1	0.7	2.8	-1.2	0.6	0.3	0.3	0.9	0.8	1.7	0.3	-0.9	0.5
Neuroticism	0.3	0.8	4.8	0.1	-0.4	-0.5	-0.5	-1.3	0.1	-2.2	0.4	0.4	-0.6
Chronotype (morning person)	0.2	0.5	3.2	1.8	-0.3	-0.5	-0.6	0.3	-0.2	0.6	-0.3	0.9	0.3
Hair Pigment	0.0	0.7	2.7	-1.1	-0.1	1.0	0.9	-1.6	0.3	-0.6	0.3	-0.8	-0.1
Tanning	0.1	0.8	3.5	-1.9	0.4	0.7	0.7	0.1	0.3	1.5	0.3	-0.4	-0.5
Hand grip strength (left)	0.8	2.0	5.0	2.2	1.7	1.6	1.7	1.4	0.8	0.9	-0.4	0.3	1.7
Number of treatments/medications taken	0.2	0.4	1.2	-0.7	-0.3	-0.7	-0.8	-0.8	0.0	0.0	0.4	1.1	0.1
Average weekly spirits intake	1.4	1.7	5.4	0.7	1.5	0.8	0.8	0.6	1.5	2.3	-0.4	0.3	2.1
Sensitivity / hurt feelings	0.7	1.2	3.9	-1.5	-0.7	-0.7	-0.8	-1.5	0.6	-2.0	0.3	-1.1	-0.5
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.8	-0.1	-0.9	-0.7	-0.7	-0.3	-1.6	-1.9	-1.3	-0.1	-2.0
Hearing difficulty/problems: Yes	0.1	0.2	1.0	0.6	-0.2	-0.1	-0.1	-0.1	0.3	-0.6	-0.2	-0.1	1.0
Relative age of first facial hair	0.3	0.7	2.1	1.1	-0.4	-0.4	-0.5	-0.5	1.4	-0.5	1.5	-0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	3.1	0.3	0.5	0.4	0.4	0.7	-0.0	0.9	0.4	0.2	1.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.9	0.5	-0.2	-0.1	0.0	-0.7	-1.6	-0.2	-1.4	-1.3	-1.7
Ever had hysterectomy (womb removed)	0.3	0.4	2.9	0.3	-0.1	0.2	0.1	1.7	0.4	-0.6	-0.0	-0.3	-0.2
Systolic blood pressure, automated reading	0.3	0.9	3.5	0.6	0.4	0.5	0.5	-0.6	0.0	1.7	1.3	1.9	0.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.8	1.3	1.3	0.7	0.7	-0.5	0.6	-0.3	0.8	1.7	1.1
Angina	0.2	0.3	1.2	-0.9	0.5	0.0	0.1	-0.6	0.3	1.1	0.4	-0.3	0.4
Medication for hormone replacement therapy	0.4	0.4	2.4	0.2	0.2	0.2	0.2	0.6	0.4	1.6	-0.4	-0.5	-0.7
Vitamin and mineral supplements	0.3	0.4	2.0	0.4	-0.5	-0.3	-0.3	-0.4	-0.5	-1.4	-1.0	-0.2	-0.3
Supplements: Zinc	0.4	0.5	1.9	-0.0	-0.6	-0.4	-0.4	0.8	-0.4	-1.4	-1.1	0.3	-0.3
Medication: Co-codamol	1.7	2.0	4.6	-0.6	1.5	1.1	1.2	-0.4	1.8	1.8	1.9	0.5	2.1
Medication: Metformin	0.5	0.7	1.7	-0.7	-0.8	-0.9	-0.8	-0.5	-0.9	-1.3	-0.4	-0.2	-1.0
Diabetes (father)	0.9	1.2	2.2	1.0	1.0	0.8	0.9	1.5	0.9	-1.0	1.4	0.5	1.4
Diabetes (mother)	0.5	0.6	1.3	-0.8	0.7	0.4	0.6	-0.6	1.1	-1.1	0.1	0.5	1.0
Severe depression (siblings)	0.4	0.5	1.6	0.7	-0.2	0.3	0.3	-0.1	-1.3	-0.4	-0.5	-0.5	-1.2
Pack years adult smoking proportion	0.4	0.6	2.5	0.8	0.3	-0.1	-0.1	-1.6	-0.2	0.4	-1.0	0.8	-0.5
Impedance of leg (right)	0.2	0.9	4.1	0.3	-0.7	-0.9	-1.0	-1.2	-0.9	0.1	-0.5	-0.4	-2.0
Leg fat-free mass (left)	0.3	1.4	2.1	1.2	1.2	1.3	1.5	0.1	1.3	-1.1	0.7	1.4	1.4
Trunk fat percentage	0.8	3.4	7.3	-1.1	-2.5	-2.7	-2.7	-2.5	-0.5	-1.5	-0.7	-1.1	-1.0
Hand grip strength (right)	0.6	1.6	3.8	1.9	1.6	1.5	1.7	1.1	0.7	-0.3	-0.7	0.3	1.3
Townsend deprivation index at recruitment	0.7	1.0	2.4	-0.3	1.1	1.2	1.2	1.0	-0.2	1.6	-1.3	0.4	-0.2
Current tobacco smoking	1.1	1.7	2.7	1.1	1.5	1.4	1.4	1.1	-1.0	-1.0	-1.7	1.6	-1.2
Average weekly fortified wine intake	1.0	1.2	4.0	0.3	0.9	0.9	0.9	-0.9	1.3	0.3	1.4	0.7	2.0
Maternal smoking around birth	1.6	2.3	5.0	0.8	1.7	2.2	2.2	1.0	0.2	2.0	-0.1	1.9	0.7
Fed-up feelings	0.3	0.5	3.1	-0.5	-0.3	-0.1	-0.1	-0.3	-0.2	-1.8	-0.8	-0.0	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.5	-0.9	-0.7	-0.7	-0.6	-0.9	-1.4	-1.6	-0.7	-0.2	-1.2
Relative age voice broke	0.7	1.1	3.2	1.4	-1.2	-1.1	-1.0	0.2	0.5	-1.8	1.3	-0.3	0.2
Taking other prescription medications	0.4	0.6	1.1	0.3	0.9	0.6	0.6	-0.0	0.9	0.8	0.7	1.0	1.0
Age when periods started (menarche)	0.3	0.7	2.2	-0.5	-0.0	0.0	0.1	0.6	-1.2	1.5	-1.4	0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.6	0.5	0.2	0.4	0.3	0.7	-0.7	0.8	-0.5	1.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	-1.1	0.4	0.1	0.1	0.8	-0.0	0.9	0.8	0.4	1.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.3	0.9	1.1	1.5	1.4	1.1	0.5	1.1	1.2	-0.8	0.7
Qualifications: CSEs or equivalent	0.3	0.3	1.1	1.0	-0.1	0.2	0.3	-0.2	0.1	-1.0	-0.8	0.7	0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.4	0.4	-0.1	-0.0	-0.0	-0.3	0.3	-0.2	-0.7	-0.0	0.1
High blood pressure	0.2	0.6	1.2	0.2	-1.0	-1.1	-1.0	0.7	-0.4	-0.8	0.7	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.5	0.7	-0.1	0.1	0.2	1.0	0.8	-1.1	1.6	-0.8	0.8
Multivitamins +/- minerals	0.2	0.2	1.2	-0.7	0.3	0.1	0.1	0.4	0.2	0.6	1.1	0.0	0.3
Stomach or abdominal pain in last month	1.7	2.2	4.7	-0.6	-1.3	-1.5	-1.5	-1.1	-2.2	-1.2	-1.7	-0.4	-2.1
Supplements: Glucosamine	1.0	1.3	5.4	-2.3	-0.5	-0.3	-0.4	-1.7	-0.8	1.1	0.3	-0.6	-1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.0	-0.1	0.8	1.0	0.9	-1.0	1.0	-0.0	-0.7	0.6	0.3
Medication: Atenolol	0.4	0.5	2.2	-1.5	-0.2	-0.5	-0.5	-0.9	-0.5	-0.3	0.5	-0.9	0.1
Medication: Levothyroxine sodium	0.7	1.2	2.8	-1.1	-1.5	-1.2	-1.3	-0.6	-0.4	-1.2	0.4	-1.7	0.8
Sitting height	0.2	1.2	2.7	1.4	1.5	1.6	1.6	0.2	0.3	-0.6	-0.1	1.4	0.4
Chronic bronchitis/emphysema (father)	1.1	1.2	4.7	0.4	-0.3	-0.5	-0.6	-2.2	-1.3	1.6	-1.1	0.6	-1.1
High blood pressure (mother)	0.5	0.7	3.4	0.5	-0.1	-0.7	-0.6	-1.8	0.1	-0.9	-0.5	1.2	0.1
Body mass index (BMI)	0.1	0.3	1.1	-0.0	-0.6	-0.4	-0.3	-0.4	1.0	-0.5	0.4	-0.3	1.0
Impedance of leg (left)	0.3	1.4	4.3	-0.2	-0.8	-1.2	-1.2	-1.9	-1.1	0.8	-0.7	-0.1	-2.1
Leg predicted mass (left)	0.3	1.4	2.3	1.2	1.2	1.4	1.5	0.0	1.3	-1.1	0.6	1.4	1.4
Trunk fat mass	0.3	1.5	4.2	-0.4	-1.6	-1.7	-1.6	-2.0	-0.0	-1.5	-0.4	-0.3	-0.4
Waist circumference	0.2	0.8	3.1	0.5	-0.6	-0.6	-0.6	-1.8	0.4	-1.7	0.4	0.1	0.2
Number of incorrect matches in round	0.4	0.6	2.4	-0.7	0.4	0.9	0.9	-0.2	0.6	1.5	0.5	-0.4	0.9
Past tobacco smoking	0.3	0.6	1.6	1.3	-0.7	-0.9	-0.8	0.3	1.0	0.5	-0.4	-1.1	-0.3
Alcohol usually taken with meals	0.4	0.7	3.2	-0.0	0.4	0.1	0.1	-0.6	0.6	-1.0	1.8	0.4	1.2
Nervous feelings	0.4	0.8	6.0	-0.3	-0.6	-0.5	-0.5	-2.5	-0.4	-0.5	-0.7	-0.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	8.4	-0.4	-2.3	-2.0	-2.0	-1.0	-0.8	-2.9	-0.9	-1.6	-1.6
Hearing difficulty/problems with background noise	0.1	0.2	0.6	0.4	-0.1	-0.0	-0.1	-0.7	-0.4	0.8	-0.4	-0.2	0.4
Hair/balding pattern: Pattern 2	2.9	3.7	7.4	2.7	2.4	2.6	2.6	2.2	0.8	-0.1	0.5	1.4	1.7
Had menopause	0.2	0.2	1.1	-1.1	-0.1	0.1	0.1	0.2	0.4	0.5	-0.5	-0.2	-0.6
Had other major operations	0.5	0.6	1.5	0.7	0.7	1.2	1.2	-0.2	0.6	-0.6	-1.0	0.7	-0.2
Forced vital capacity (FVC)	0.2	0.6	1.6	0.3	1.2	0.9	1.0	1.3	0.4	0.8	0.4	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.2	-1.3	0.2	0.1	0.1	0.5	0.8	0.4	1.2	-0.1	1.5
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.2	-0.8	-0.1	0.0	-0.0	1.3	-1.2	-1.0	-1.0	-1.8	-0.6
Qualifications: None of the above	1.6	3.5	8.8	-2.0	-2.5	-2.2	-2.2	-2.2	-0.6	-0.2	0.2	-3.0	-1.0
Financial difficulties in last 2 years	0.4	0.5	2.7	1.1	-0.1	-0.2	-0.1	1.6	-0.3	-0.6	0.1	0.7	-0.3
Mouth/teeth dental problems	0.2	0.2	0.8	-0.5	0.0	0.0	0.1	-0.4	-0.7	0.8	-0.9	0.2	-0.4
Heart attack	1.6	2.1	4.9	-1.7	-1.4	-2.0	-2.0	-2.2	-1.2	-0.3	0.6	-0.3	-0.9
Allergy	0.1	0.3	0.9	-0.3	0.0	-0.2	-0.2	-0.5	-0.5	0.5	-0.9	0.2	-0.8
Pain all over the body in last month	0.5	0.5	2.6	1.6	0.3	-0.0	0.1	-0.9	0.0	0.3	-0.7	1.0	-0.4
Diabetes (self-reported)	1.2	1.8	5.9	-0.5	-1.7	-2.0	-2.0	0.3	-0.6	-2.4	0.5	-0.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	0.2	0.5	0.4	0.3	0.7	1.2	-0.2	-1.0	0.9	-0.2
Medication: Ramipril	0.2	0.2	0.5	0.1	-0.6	-0.7	-0.6	0.0	0.1	-0.4	0.1	-0.6	-0.5
Medication: Simvastatin	0.3	0.5	2.4	0.5	-0.3	-0.6	-0.7	-0.4	0.3	-0.3	1.6	0.3	0.8
Fluid intelligence score	0.3	0.7	1.9	0.6	1.1	0.7	0.7	0.2	1.4	0.1	0.6	1.0	0.9
Illnesses of siblings	0.6	0.8	3.3	-0.3	0.9	1.0	1.0	0.6	-1.1	0.4	0.3	1.8	0.4
Neuroticism score	0.3	0.6	3.3	0.3	-0.1	0.1	0.0	-0.8	-0.2	-1.8	-0.7	0.7	-0.8
Weight	0.1	0.6	1.4	1.0	0.4	0.5	0.6	-0.8	1.1	-1.0	0.2	1.2	0.5
Impedance of arm (right)	0.8	3.9	7.2	-1.3	-2.4	-2.5	-2.5	-1.1	-1.7	-1.7	-1.2	-1.9	-2.7
Arm fat percentage (right)	0.3	1.2	2.9	-0.9	-1.7	-1.6	-1.6	-1.0	0.3	-0.8	0.1	-1.0	0.1
Trunk fat-free mass	0.9	5.2	12.1	2.1	3.0	3.4	3.5	0.8	1.6	-0.3	0.7	2.9	1.6
Hip circumference	0.2	0.8	3.2	0.2	-0.9	-0.7	-0.7	-1.2	0.7	-1.8	0.6	-0.3	0.7
Time employed in main current job	0.5	0.5	1.6	0.2	-0.3	-0.7	-0.7	1.3	-0.1	-0.8	-0.6	-1.2	0.4
Alcohol intake versus 10 years previously	0.7	1.0	4.1	1.8	-0.2	-0.5	-0.5	0.0	-1.3	-0.5	-2.0	0.9	0.2
Father’s age at death	1.0	1.3	2.8	0.4	-1.0	-1.5	-1.5	-0.6	-0.0	-1.6	1.7	-1.1	-0.4
Worrier / anxious feelings	0.2	0.3	0.8	0.4	-0.6	-0.5	-0.5	-0.4	-0.0	-0.8	-0.5	-0.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	8.3	-1.0	-1.4	-1.2	-1.2	-0.1	-1.1	-2.9	-0.6	-1.2	-0.5
Falls in the last year	0.3	0.5	2.8	-0.6	-0.1	-0.4	-0.5	-0.6	0.6	-0.3	-0.3	1.7	-0.4
Hair/balding pattern: Pattern 3	1.2	1.8	3.9	-1.6	-1.3	-1.4	-1.3	-0.4	-1.8	-1.1	-0.8	-1.0	-2.0
Number of live births	0.4	0.5	3.4	-0.1	0.1	0.1	0.0	-1.9	-1.0	0.4	-0.3	0.2	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.8	0.6	1.0	0.7	0.8	1.7	1.1	0.4	1.2	-0.3	1.1
Pulse rate	1.1	1.9	3.2	1.7	1.4	1.5	1.5	1.3	-0.6	1.5	-1.8	0.8	-1.2
Happiness	1.1	1.3	8.5	0.4	-0.9	-0.6	-0.6	0.9	-0.9	-2.9	-0.2	-0.8	-0.8
Noisy workplace	0.5	0.7	1.3	-0.9	-1.2	-0.8	-0.8	0.4	-1.1	-0.0	-0.7	-1.1	-0.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.5	2.1	2.1	1.9	2.0	1.6	1.4	0.9	1.3	1.6	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	3.1	0.4	0.1	-0.1	-0.2	-1.0	-0.3	1.7	-0.0	-0.7	0.6
Mouth/teeth dental problems: Dentures	1.1	1.8	4.8	0.4	-0.4	-0.2	-0.2	1.3	2.2	-1.1	1.8	-1.4	2.2
Asthma	0.4	0.7	1.9	-0.2	-1.3	-1.4	-1.4	-0.3	-0.1	-1.1	0.2	0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.9	0.5	1.3	1.2	1.1	0.7	-0.8	1.7	-0.7	1.3	0.7
Medication: Cholesterol lowering	0.7	1.1	4.1	0.5	-0.8	-1.2	-1.2	-1.3	0.2	-0.8	2.0	0.0	0.7
Depression (self-reported)	1.1	1.4	3.2	-1.3	-0.9	-1.2	-1.2	-1.8	-1.5	-0.5	-0.3	0.4	-1.6
Medication: Lansoprazole	0.5	0.5	2.2	-0.8	-0.5	-0.6	-0.7	-0.9	-0.0	-0.1	-1.5	0.8	-0.1
Prospective memory result	2.7	3.3	15.9	0.3	1.2	1.3	1.2	1.3	1.1	4.0	1.3	2.2	1.6
Lung cancer (father)	1.3	1.5	3.6	1.9	1.5	1.7	1.7	-0.2	0.8	0.3	0.2	0.9	1.2
Illnesses of mother	1.4	1.7	5.0	0.2	0.8	1.2	1.3	2.2	1.1	1.9	1.2	-1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.2	0.4	0.8	0.7	0.8	0.7	1.8	-0.0	1.0	-0.1	0.8
Pulse wave Arterial Stiffness index	0.9	1.1	5.2	-0.6	0.9	1.0	0.9	-1.4	0.8	2.3	-0.2	0.1	0.3
Impedance of arm (left)	1.1	4.9	9.2	-1.0	-2.6	-2.9	-2.9	-1.3	-2.2	-2.0	-1.5	-1.5	-3.0
Arm fat mass (right)	0.1	0.3	0.7	-0.1	-0.6	-0.5	-0.4	-0.8	0.7	-0.8	-0.1	0.3	0.5
Trunk predicted mass	0.9	5.3	12.4	2.1	3.1	3.4	3.5	0.9	1.6	-0.2	0.7	2.9	1.7
Standing height	0.3	3.2	10.7	2.0	2.0	2.0	2.1	-1.4	0.1	-1.3	-0.7	3.3	-0.9
Length of working week for main job	0.6	0.7	2.6	-0.5	-0.2	-0.2	-0.3	1.4	0.0	-1.3	-1.6	-0.0	-0.5
Exposure to tobacco smoke at home	0.4	0.4	1.3	-0.3	-0.1	0.0	0.0	1.1	-1.0	-0.7	-0.1	-1.1	-0.3
Breastfed as a baby	1.1	1.3	3.0	0.1	-1.2	-1.1	-1.1	-0.6	-0.4	-1.7	1.7	-1.7	0.4
Tense / ‘highly strung’	0.8	1.3	4.0	-0.6	-0.8	-0.7	-0.8	-2.0	-0.2	-1.3	-0.8	1.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.0	-0.1	-0.1	-0.4	-0.5	-0.5	-0.9	-1.4	-0.2	0.3	-0.6
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	-0.1	-0.9	-0.7	-0.6	-0.1	0.7	1.0	-0.5	-0.9	0.1
Birth weight of first child	0.9	1.5	4.1	-1.4	-1.0	-0.9	-0.9	-2.0	-0.1	-1.9	1.1	-0.8	1.1
Peak expiratory flow (PEF)	0.2	0.6	1.4	0.6	-0.6	-0.8	-0.8	1.2	0.7	-0.3	0.8	-0.5	0.9
Pulse wave reflection index	0.7	0.9	2.4	0.1	0.9	1.0	0.9	-0.7	1.6	1.2	1.0	0.2	1.2
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.2	-0.8	-0.0	-0.0	0.0	0.9	-0.7	-1.5	-2.1	0.4	-0.7
Loud music exposure frequency	1.6	1.7	3.5	-1.3	1.5	1.8	1.9	1.8	1.0	0.9	0.5	0.7	0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	8.0	1.9	1.5	1.3	1.3	1.3	1.0	0.5	-0.1	2.8	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	-0.1	0.6	0.2	0.2	0.0	-0.5	-0.6	0.2	0.4	-0.9
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.1	0.8	0.7	0.7	-0.6	-0.8	-0.2	-0.7	0.1	-0.8
Medication: Paracetamol	1.2	1.9	7.9	-1.3	-1.5	-1.3	-1.3	0.1	-0.4	-2.8	-0.5	-1.0	-1.6
Headache pain in last month	1.7	2.9	7.8	-0.1	-1.8	-1.4	-1.3	0.4	-2.8	-1.2	-1.6	-2.0	-2.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.4	0.3	1.3	1.8	1.8	0.7	0.5	1.0	-0.9	0.6	-0.0
Glaucoma (self-reported)	0.4	0.5	2.7	0.3	-0.7	-0.3	-0.4	-1.6	0.2	-0.4	-0.1	1.1	0.3
Gout (self-reported)	1.0	1.3	2.9	0.2	-1.4	-1.7	-1.7	0.5	-1.1	-1.0	-0.5	-0.9	-1.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.5	-1.4	-1.4	-0.9	-1.0	-1.0	-0.6	-1.5	0.5	-1.6	-0.0
Medication: Amlodipine	0.3	0.4	1.9	0.2	-0.1	-0.2	-0.2	0.3	-1.4	1.1	-0.4	0.5	-0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.7	-0.1	1.6	1.6	1.5	0.8	1.9	-0.1	0.6	0.8	1.6
Birth weight	0.5	1.0	2.5	0.3	-0.8	-1.3	-1.2	-0.8	0.7	-1.5	-1.6	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	4.6	0.8	0.3	0.4	0.3	2.1	-0.3	0.2	0.4	-0.6	0.6
High blood pressure (siblings)	0.7	0.9	5.1	0.9	0.8	0.7	0.8	0.6	2.3	0.6	0.2	-0.7	0.6
Forced vital capacity (FVC), Best measure	0.0	0.1	0.5	-0.4	0.5	0.4	0.4	0.0	0.7	0.1	0.2	0.1	0.1
Body fat percentage	0.6	2.2	4.7	-1.0	-2.0	-2.2	-2.2	-2.1	-0.1	-1.0	-0.4	-1.3	-0.7
Leg fat percentage (right)	0.2	0.9	1.6	-0.2	-1.2	-1.2	-1.2	-1.1	0.7	-0.5	0.7	-1.3	0.1
Arm fat-free mass (right)	0.6	3.3	6.9	2.0	2.4	2.5	2.6	-0.5	1.2	-0.2	0.1	2.6	1.1
Exposure to tobacco smoke outside home	0.2	0.3	1.6	-0.1	-0.5	-0.4	-0.3	-0.3	0.6	-0.1	0.3	-0.0	1.3
Comparative body size at age 10	3.4	9.5	18.7	-2.9	-3.8	-4.3	-4.3	-2.7	-2.0	-0.3	-0.2	-4.2	-2.5
Number of full brothers	0.2	0.3	0.9	0.1	-0.4	-0.4	-0.4	-0.7	0.7	1.0	-0.6	-0.1	0.4
Worry too long after embarrassment	0.6	1.0	5.9	1.3	-0.4	-0.2	-0.2	0.5	-0.2	-2.4	-1.0	0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.6	0.1	-1.6	-1.9	-1.9	-1.6	-0.7	-1.8	0.2	-0.1	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.5	0.3	-0.7	-0.2	-0.2	0.4	-0.3	-0.3	-0.3	0.5	-0.4
Number of children fathered	0.9	1.1	4.9	-0.6	-0.7	-0.8	-0.7	0.7	-1.2	2.2	-0.6	-0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.4	-0.5	-0.1	-0.1	-0.2	-0.3	0.3	-1.2	1.0	0.2	-0.8
Age at first live birth	0.3	0.5	1.2	0.6	0.1	0.1	0.1	1.1	-1.1	-1.0	-0.5	0.5	-0.7
Pulse wave peak to peak time	1.1	1.2	6.7	0.8	-0.9	-1.0	-0.9	1.4	-0.8	-2.6	0.0	0.1	-0.3
Health satisfaction	0.6	0.7	2.7	-1.6	-0.1	0.1	0.1	1.4	-1.0	-0.4	-0.0	-1.1	-0.4
Shortness of breath walking on level ground	1.7	2.1	5.6	-1.2	-1.0	-1.5	-1.5	-1.8	-1.3	-1.0	-2.4	-0.5	-1.4
Qualifications: College or University degree	0.1	0.2	1.5	0.7	0.2	0.0	-0.1	-0.3	-0.3	-1.2	0.4	0.1	-0.0
Eye problems/disorders: None of the above	0.5	0.6	2.6	-0.8	0.3	0.2	0.3	-0.3	-0.2	0.6	-1.6	0.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	0.7	0.5	0.3	0.3	1.1	-0.7	-0.4	-0.5	1.3	0.5
Emphysema/chronic bronchitis	0.5	0.5	2.1	1.4	0.1	0.5	0.5	0.0	-0.6	-0.3	-1.0	0.8	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.6	4.1	2.0	0.3	0.1	0.3	-0.4	-0.3	0.5	-0.8	0.7	-0.4
Neck or shoulder pain in last month	2.1	2.9	8.5	-1.2	-2.3	-2.1	-2.1	-2.9	0.2	1.2	-0.5	-1.8	-0.2
Medication: Blood pressure	0.8	1.4	4.0	-0.6	-1.5	-2.0	-2.0	-0.1	-1.2	-0.9	0.0	-0.7	-0.9
Angina (self-reported)	0.3	0.4	1.8	-0.7	0.6	0.1	0.1	-0.6	0.5	1.4	0.5	-0.2	0.4
Migraine (self-reported)	0.1	0.2	0.9	0.6	-0.4	0.1	0.1	0.6	0.1	-0.1	0.1	-0.9	0.1
Medication: Ibuprofen	0.9	1.0	2.4	1.0	1.1	0.9	0.9	0.2	-1.1	1.5	-0.9	1.6	0.3
Medication: Allopurinol	0.6	0.8	2.2	-0.1	-1.1	-1.5	-1.5	0.2	-0.5	-0.8	0.6	-0.6	-0.7
Medication: Omeprazole	0.2	0.3	1.3	0.5	0.4	0.2	0.2	-0.7	-0.1	1.2	0.2	-0.3	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	2.3	-1.0	0.8	0.7	0.7	-0.2	1.5	0.8	0.0	0.8	0.8
Mean time to correctly identify matches	0.2	0.4	1.2	0.5	-1.0	-1.0	-0.9	1.1	0.3	-0.2	0.0	-0.1	-0.2
Heart disease (mother)	0.8	0.9	2.9	-1.4	-0.7	-0.6	-0.6	-1.7	0.5	-0.9	1.4	-0.5	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.8	-0.6	-0.0	0.2	0.2	-0.2	-0.0	-1.4	-0.7	0.3	0.2
Whole body fat mass	0.2	0.7	2.9	-0.3	-1.1	-1.0	-1.0	-1.7	0.4	-1.0	0.0	-0.2	-0.1
Leg fat mass (right)	0.1	0.5	1.5	0.0	-0.8	-0.6	-0.6	-1.2	0.9	-0.9	0.7	-0.4	0.3
Arm predicted mass (right)	0.5	2.5	5.2	1.9	2.0	2.1	2.2	-0.4	1.2	-0.1	0.1	2.3	1.2
Pulse rate, automated reading	0.2	0.5	2.7	1.6	-0.4	-0.4	-0.3	-0.0	-0.6	0.1	0.0	0.0	-1.3
Alcohol intake frequency.	0.5	1.1	2.3	-1.0	-1.4	-1.5	-1.5	0.7	-0.5	-0.2	-0.8	-1.1	-0.9
Comparative height size at age 10	0.3	1.9	6.2	1.5	1.5	1.6	1.6	-1.5	0.1	-0.8	0.6	2.5	0.3
Number of full sisters	0.9	1.1	2.3	0.2	1.3	1.3	1.2	0.6	-0.6	1.5	-1.3	1.3	0.2
Suffer from ‘nerves’	0.4	0.6	3.2	0.2	-0.6	-0.7	-0.7	-0.9	-0.6	-1.8	0.1	-0.0	-0.6
Overall health rating	0.4	0.8	1.8	0.3	-1.1	-0.7	-0.7	0.3	-0.9	-1.3	-1.3	0.8	-1.0
Chest pain or discomfort	0.4	0.5	1.5	0.5	0.8	1.1	1.1	0.3	0.0	0.4	0.3	1.2	-0.5
Had major operations	0.4	0.4	1.3	-0.3	-0.2	0.6	0.5	0.7	1.1	-0.3	0.4	0.7	1.0
Age at last live birth	0.9	1.4	3.0	1.7	1.1	1.3	1.3	1.7	-0.8	0.3	-0.2	1.4	-0.6
Family relationship satisfaction	1.1	1.3	3.2	-0.3	-0.9	-0.6	-0.6	1.7	-1.5	-1.8	-0.2	-1.5	-0.8
Leg pain on walking	0.7	0.8	2.0	-1.0	1.2	1.3	1.2	1.4	-0.3	0.4	-0.7	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	7.3	0.4	0.3	0.8	0.9	2.7	-0.2	-0.8	-0.9	1.1	-0.5
Commuting to job workplace: Car/motor vehicle	1.5	1.8	4.1	-0.5	-1.3	-1.3	-1.2	-0.6	-1.6	0.4	-2.0	-1.1	-2.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.2	-1.1	0.0	0.5	0.4	0.4	-0.5	-0.6	0.0	-0.3	-0.4
Medication: Aspirin	0.9	1.2	3.1	-0.5	-1.4	-1.0	-1.1	-1.8	0.1	-0.3	1.7	-1.4	-0.2
Supplements: Vitamin C	1.2	1.4	6.5	-2.6	-1.1	-1.4	-1.4	0.7	-0.2	-1.0	0.3	-1.1	-0.4
Knee pain experienced in last month	0.2	0.3	1.5	-1.2	-0.1	0.1	0.1	-0.2	0.6	0.4	0.7	0.5	0.4
Hypertension (Self-reported)	0.4	1.0	1.8	-0.2	-1.2	-1.3	-1.3	1.0	-0.8	-1.2	0.6	-1.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.4	-1.5	0.5	0.6	0.6	0.0	0.2	1.2	0.4	-0.6	0.3
Illnesses of father: Heart disease	0.5	0.7	2.2	-0.5	-0.8	-0.8	-0.9	1.5	0.1	-0.4	-0.2	-1.5	0.4
Illnesses of siblings: Diabetes	0.6	0.7	2.1	0.2	0.6	0.5	0.5	1.0	1.4	0.7	0.3	0.8	1.3
Smoking status: Previous	0.3	0.5	1.8	-1.3	0.4	0.8	0.7	-0.4	-0.5	0.1	0.8	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.4	0.8	-0.0	-0.3	-0.2	-2.1	-0.8	0.8	-1.5	2.0	-1.6
Whole body fat-free mass	0.5	3.1	6.6	1.7	2.2	2.5	2.6	0.3	1.5	-0.5	0.6	2.3	1.5
Leg fat-free mass (right)	0.2	1.3	2.3	1.0	1.2	1.3	1.4	-0.1	1.3	-1.0	0.6	1.5	1.4
Arm fat percentage (left)	0.4	1.6	3.9	-0.9	-2.0	-1.9	-1.9	-1.2	0.1	-1.2	0.1	-1.1	-0.1
Average weekly red wine intake	0.5	0.7	2.2	-0.1	-0.5	-0.4	-0.4	-0.7	0.5	0.9	1.5	-1.0	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.0	-0.6	-1.0	-1.0	-0.0	-0.2	-0.5	1.1	-1.0	0.2
Mood swings	1.5	2.8	10.2	-0.5	-1.5	-1.4	-1.4	-1.1	-1.3	-3.2	-2.1	-0.6	-1.9
Loneliness, isolation	1.3	1.8	3.1	1.5	1.5	1.7	1.7	1.1	-0.2	-1.4	-1.3	1.5	-0.7
Long-standing illness, disability or infirmity	0.5	0.8	3.4	-0.6	-0.9	-0.6	-0.5	-0.8	0.0	-1.8	1.2	-1.0	0.3
Ever had bowel cancer screening	0.4	0.4	2.4	-0.4	-0.2	-0.4	-0.5	-1.6	0.2	0.8	0.3	-0.1	-0.6
Diabetes diagnosed by doctor	0.3	0.6	4.1	-0.3	-0.5	-0.7	-0.7	0.2	-0.1	-2.0	-0.1	0.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.3	1.3	-0.1	-0.4	-0.4	-1.1	-1.5	0.6	-0.5	-0.5	-1.2
Friendships satisfaction	0.5	0.6	4.3	2.1	-0.2	-0.2	-0.2	0.5	-0.6	-0.2	-0.4	0.2	-0.8
Qualifications: nursing, teaching	0.7	1.1	4.9	0.5	-0.7	-1.1	-1.1	0.9	-0.3	-2.2	0.8	-1.3	-0.3
Commuting to job workplace: Walk	1.7	1.8	6.5	1.0	1.0	0.9	0.9	0.2	1.5	-2.6	1.9	1.1	1.1
Eye problems/disorders: Cataract	1.1	1.2	3.8	0.2	-0.9	-0.9	-1.1	-0.0	0.2	-1.3	1.9	-0.6	1.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	-0.2	0.6	0.6	0.6	0.1	0.0	0.5	0.8	0.1	0.1
Medication for cholesterol	0.8	1.1	2.4	1.5	1.3	1.4	1.3	0.7	-0.3	-0.3	0.2	1.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.3	-0.9	0.0	0.2	0.2	-0.1	-0.0	1.1	-0.1	-0.6	-0.2
Back pain experienced in last month	0.3	0.4	1.0	0.8	-1.0	-0.8	-0.8	0.6	-0.0	-0.4	-0.5	-0.4	-0.6
Mineral and other dietary supplements	0.7	0.9	3.1	1.2	0.0	-0.0	-0.0	0.7	0.7	-1.4	1.0	0.5	1.8
Breast cancer (self-reported)	0.5	0.6	3.8	0.5	0.3	0.4	0.4	2.0	0.5	-0.5	-0.1	-0.0	1.2
Asthma (self-reported)	0.3	0.6	1.5	0.1	-1.1	-1.1	-1.2	-0.2	-0.0	-1.2	0.2	0.5	0.4
Osteoporosis (self-reported)	0.8	1.0	2.5	-0.4	-1.2	-1.1	-1.1	-0.1	-1.6	-0.8	-0.9	-0.8	-1.1
Osteoarthritis (self-reported)	1.1	1.4	2.6	0.5	1.4	1.3	1.3	0.7	1.6	1.4	0.7	1.2	0.9
Medication: Aspirin	1.0	1.2	3.9	-0.9	-1.3	-1.1	-1.1	-1.3	0.5	-0.0	2.0	-1.2	0.4
Medication: Gliclazide	3.6	4.1	9.1	-1.8	-2.6	-2.8	-2.8	-0.9	-1.4	-3.0	-0.4	-1.5	-1.3
Illnesses of father: None of the above (group 1)	0.8	1.0	5.9	-0.5	0.7	0.9	1.0	-2.4	0.2	0.4	0.1	1.1	-0.2
Smoking status: Current	1.1	1.8	3.1	1.1	1.7	1.5	1.5	1.2	-1.0	-0.8	-1.5	1.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.2	-0.1	-0.4	-0.5	-0.5	0.0	1.4	-0.0	2.0	-0.9	0.6
Whole body water mass	0.5	3.1	6.7	1.6	2.2	2.5	2.6	0.5	1.4	-0.6	0.5	2.2	1.4
Leg predicted mass (right)	0.3	1.4	2.2	1.0	1.2	1.4	1.5	-0.0	1.3	-0.9	0.6	1.5	1.4
Arm fat mass (left)	0.1	0.5	1.1	-0.2	-1.0	-0.8	-0.8	-1.0	0.6	-1.0	-0.1	0.0	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	0.1	-0.0	-0.3	-0.3	-0.2	0.4	0.8	0.2	0.4	0.8
Average weekly champagne plus white wine intake	1.0	1.3	3.7	-1.1	-1.1	-0.8	-0.8	-1.9	-1.1	-0.9	0.0	-1.2	-1.4
Miserableness	0.6	1.0	4.5	0.0	-0.7	-0.7	-0.7	0.2	-1.2	-2.1	-0.8	-1.1	-0.8
Guilty feelings	0.6	0.9	4.0	0.7	-0.4	-0.2	-0.3	0.0	-1.2	-1.6	-0.6	-0.2	-2.0
Wears glasses or contact lenses	0.6	0.7	1.4	0.6	0.5	1.2	1.1	1.0	-0.3	1.2	-0.6	-0.8	-0.7
Ever taken oral contraceptive pill	1.0	1.1	2.5	-0.9	-1.3	-1.6	-1.5	0.0	0.3	-1.1	0.9	-0.7	1.1
Hearing aid user	0.5	0.5	2.9	1.7	0.2	0.4	0.3	0.6	-0.7	0.3	-0.5	0.5	0.8
Mother’s age at death	0.5	0.6	4.0	0.3	-0.6	-0.8	-0.9	-2.0	0.1	-0.7	0.2	-0.3	-0.1
Financial situation satisfaction	0.8	1.0	2.9	-0.3	-1.3	-0.9	-0.9	1.6	-0.7	-0.2	0.2	-1.7	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.2	0.5	-0.6	-0.5	-0.3	0.8	1.2	0.1	1.0	0.4	1.8
Commuting to job workplace: Public transport	2.3	2.7	6.6	1.3	2.0	1.7	1.7	1.4	2.6	-0.2	1.8	0.6	1.9
Eye problems/disorders: Glaucoma	0.3	0.3	1.3	0.7	-0.0	0.4	0.3	0.0	-0.7	-0.7	-1.1	0.6	-0.2
Medication: Blood pressure	0.7	1.3	2.9	-1.7	-1.4	-1.5	-1.4	0.0	-0.0	-0.8	-0.3	-1.4	-1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.9	-0.2	-0.3	0.1	0.0	0.3	-0.8	-0.8	-1.7	-0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.2	-0.9	0.2	0.5	0.4	0.1	-0.7	1.1	-1.5	-0.9	-1.8
High cholesterol (Self-reported)	0.4	0.8	1.6	1.2	0.6	0.6	0.5	0.7	0.9	0.7	1.3	0.7	1.2
Medication: Bendroflumethiazide	1.0	1.5	5.7	-0.3	-1.5	-1.3	-1.3	1.6	0.3	-2.4	-0.3	-0.8	-0.3
Medication: Paracetamol	0.7	1.2	2.7	-1.2	-1.0	-1.2	-1.1	0.4	-0.6	-1.5	-0.7	-0.6	-1.7
Medication: Lisinopril	0.8	1.0	3.0	-1.7	-1.1	-1.2	-1.2	-0.5	-0.7	-0.5	-0.1	-1.1	-1.0
Medication: Atorvastatin	0.8	1.0	2.8	-1.5	0.0	-0.4	-0.5	-1.2	1.7	0.7	1.4	0.3	0.7
Illnesses of father: High blood pressure	0.9	1.1	7.7	1.1	-0.7	-0.6	-0.6	2.8	0.2	-0.4	-0.2	-0.7	-0.2
Alcohol drinker status: Never	0.6	0.8	2.3	0.7	0.6	0.1	0.0	1.5	1.3	1.2	0.7	0.5	0.7
Ever smoked	0.3	0.6	2.2	-1.1	0.4	0.3	0.3	-0.6	-1.5	-0.9	-0.6	0.6	-0.5
Basal metabolic rate	0.4	2.3	4.4	1.6	1.8	2.0	2.1	0.2	1.4	-0.6	0.5	2.1	1.4
Leg fat percentage (left)	0.3	1.0	2.1	-0.6	-1.3	-1.4	-1.4	-1.4	0.7	-0.1	0.5	-1.1	0.1
Arm fat-free mass (left)	0.5	2.5	5.2	1.7	2.0	2.2	2.3	-0.3	1.2	-0.2	0.1	2.2	1.2
Number of operations (self-reported)	0.5	0.8	2.7	-0.0	0.9	1.2	1.1	0.2	0.8	0.0	-1.6	0.9	0.5
Average weekly beer plus cider intake	0.4	0.6	1.3	0.7	0.4	0.5	0.6	1.1	-0.7	-0.7	-1.2	0.0	-0.8
Irritability	0.3	0.6	2.2	-0.1	0.6	0.9	0.8	0.5	-0.2	-1.5	-0.8	0.7	-0.3
Risk taking	0.4	0.6	1.8	-1.1	-0.3	-0.4	-0.4	-0.2	0.2	-1.4	1.1	-1.0	0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-1.1	-0.5	-0.3	-0.4	1.1	-1.1	-0.1	1.2	-1.0	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.3	0.2	-0.6	-0.9	-0.8	-0.1	0.1	-0.9	-1.1	0.5	-0.2
Age started oral contraceptive pill	0.5	0.6	2.4	-1.5	-0.0	-0.0	-0.0	-0.8	0.4	1.0	0.4	-1.1	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.3	0.8	0.1	0.1	0.1	0.3	0.3	1.1	0.6	1.0	0.4
Ever depressed for a whole week	1.0	1.2	3.1	0.3	1.4	1.8	1.7	1.1	0.1	-0.7	-1.4	-0.2	0.0
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.2	0.1	0.4	0.3	0.8	-0.3	-0.5	-0.9	-0.6	-0.4
Commuting to job workplace: Cycle	0.6	0.7	2.6	1.6	-0.1	-0.3	-0.3	1.0	-1.0	-1.3	0.1	0.2	-0.7
Myopia	0.3	0.5	1.8	-0.5	-0.3	-0.6	-0.7	-1.3	-0.3	0.1	-1.1	0.6	-0.7
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.0	0.1	0.6	0.9	0.8	-1.0	0.2	0.6	-0.8	0.3	0.1
Cholesterol lowering medication	0.4	0.5	2.0	-0.3	0.4	0.2	0.2	-0.5	1.4	1.0	1.0	0.4	0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	3.0	0.0	0.6	0.3	0.3	-0.5	0.0	1.7	0.5	-0.3	0.6
Pain experienced in last month	0.2	0.3	0.8	-0.3	0.8	0.3	0.4	0.9	0.6	-0.4	0.8	0.6	0.5
Supplements: Calcium	0.6	0.6	2.1	0.3	-0.6	-0.7	-0.7	-0.6	-0.5	-0.2	-0.8	-1.2	-1.5
Basal cell carcinoma (self-reported)	0.6	0.7	3.0	0.5	0.0	0.1	0.0	0.7	1.7	-0.8	0.2	0.5	1.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.1	-1.7	-1.5	-2.1	-2.2	-2.3	-1.1	-0.1	0.8	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.6	-0.6	0.2	0.2	0.2	-0.6	-1.2	-0.3	-0.7	-0.6	-0.9
Heart disease (siblings)	0.5	0.6	2.3	-0.2	-1.3	-0.8	-0.8	0.1	0.3	-0.7	0.0	-1.5	-0.2
Alcohol drinker status: Previous	0.3	0.4	2.7	-0.4	0.1	0.0	0.0	-0.6	-0.0	1.6	-0.0	-0.0	-0.6
Pack years of smoking	0.3	0.5	2.0	0.6	0.4	0.0	0.0	-1.4	-0.1	0.8	-1.0	0.7	-0.2
Impedance of whole body	0.7	3.7	8.0	-0.7	-2.1	-2.5	-2.6	-1.8	-1.9	-1.0	-1.6	-1.0	-2.8
Leg fat mass (left)	0.1	0.5	2.2	-0.1	-0.7	-0.7	-0.7	-1.5	0.9	-0.6	0.6	-0.2	0.5
Arm predicted mass (left)	0.6	2.9	6.4	1.7	2.2	2.5	2.5	-0.1	1.4	-0.1	0.1	2.4	1.3