Best TWAS P=4.05e-55 · Best GWAS P=8.28e-53 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | SMOC2 | 0.24 | 0.05 | lasso | 6 | 0.05 | 1.7e-04 | 7.709 | -6.9 | 4.0e-12 | 0.34 | 0.87 | 0.01 | FALSE |
| 2 | GTEx | Nerve Tibial | AL391319.1 | 0.20 | 0.04 | lasso | 4 | 0.05 | 9.5e-05 | 6.610 | -6.3 | 2.1e-10 | 0.31 | 0.80 | 0.01 | FALSE |
| 3 | GTEx | Thyroid | AL391319.1 | 0.15 | 0.12 | lasso | 4 | 0.11 | 1.0e-08 | -15.294 | 15.6 | 4.1e-55 | -0.99 | 0.00 | 1.00 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SMOC2 | 0.24 | 0.11 | bslmm | 711 | 0.17 | 5.5e-21 | -6.585 | 6.8 | 1.1e-11 | -0.13 | 1.00 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | DACT2 | 0.21 | 0.03 | enet | 59 | 0.09 | 3.1e-11 | -4.986 | 6.8 | 1.2e-11 | -0.12 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | DACT2 | 0.06 | 0.06 | blup | 45 | 0.05 | 4.6e-04 | -4.984 | 5.2 | 1.8e-07 | -0.03 | 0.07 | 0.10 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DACT2 | 0.15 | 0.07 | blup | 45 | 0.09 | 1.1e-04 | 0.089 | 5.6 | 2.4e-08 | -0.07 | 0.03 | 0.78 | FALSE |