TWAS hub - DACT2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.215	0.0480	6.2e-06	0.033	0.072	0.068	0.083	0.076	6.6e-05	3.8e-09	1.1e-08	2.4e-10	1.4e-09
2	ROSMAP	Brain Pre-frontal Cortex	0.212	0.0455	3.7e-07	0.027	0.053	0.086	0.053	0.080	1.8e-04	2.4e-07	3.1e-11	2.0e-07	1.8e-10
3	TCGA	Colon Adenocarcinoma	0.064	0.0310	5.8e-03	0.057	0.054	0.040	NA	0.041	3.2e-04	4.6e-04	2.2e-03	NA	1.9e-03
4	TCGA	Brain Lower Grade Glioma	0.079	0.0284	4.9e-06	0.052	0.057	0.038	NA	0.044	1.3e-06	4.8e-07	3.8e-05	NA	8.1e-06
5	TCGA	Pancreatic Adenocarcinoma	0.149	0.0600	6.5e-04	0.075	0.092	0.073	NA	0.080	4.7e-04	1.1e-04	5.6e-04	NA	3.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Aspirin	4.9	6.4	10.8	-2.6	-2.5	-2.0	-3.3	-2.0
Number of operations (self-reported)	4.1	6.1	14.3	3.8	2.1	1.3	2.4	2.1
Diabetes (mother)	3.7	4.7	7.2	-1.9	-1.9	-1.8	-2.7	-2.4
Townsend deprivation index at recruitment	3.7	5.2	9.3	1.8	1.6	3.1	2.3	2.3
Chest pain or discomfort	3.7	5.4	9.0	2.0	2.5	3.0	1.9	2.0
Medication: Aspirin	3.7	4.9	8.6	-2.2	-2.2	-1.7	-2.9	-1.9
Depression (self-reported)	3.6	4.4	7.3	2.7	1.6	1.4	2.3	2.2
High blood pressure (mother)	3.3	4.6	7.5	-2.7	-2.3	-1.2	-2.3	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.1	9.1	3.0	2.2	1.1	1.8	1.5
Qualifications: College or University degree	3.0	9.3	12.3	-2.9	-3.1	-3.5	-2.8	-2.8
Shortness of breath walking on level ground	2.9	3.5	6.1	1.3	1.1	2.5	1.5	2.5
Emphysema/chronic bronchitis	2.7	3.0	8.6	-0.0	1.1	1.6	1.7	2.9
Financial difficulties in last 2 years	2.6	3.5	8.2	0.3	1.7	2.9	1.7	1.8
Comparative height size at age 10	2.6	14.5	28.4	0.3	5.3	4.0	3.8	3.7
Illnesses of father: Heart disease	2.6	3.6	5.8	-0.8	-2.4	-1.9	-2.3	-1.6
Worry too long after embarrassment	2.5	4.2	7.3	-2.5	-2.0	-1.0	-2.7	-1.7
Arm predicted mass (right)	2.5	12.7	19.6	1.9	3.9	4.0	3.1	4.4
Arm fat-free mass (left)	2.5	12.7	18.0	1.8	4.1	3.9	3.3	4.2
Crohns Disease (2012)	2.3	3.7	6.8	2.6	2.1	1.3	2.0	1.3
Illnesses of mother	2.3	2.8	4.6	2.1	1.9	0.9	1.2	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.7	6.8	0.9	1.6	2.6	1.2	1.4
Irritability	2.2	3.8	8.0	0.2	2.1	2.8	1.4	2.1
Arm predicted mass (left)	2.2	10.9	15.5	1.6	3.8	3.6	3.0	3.9
Arm fat-free mass (right)	2.1	10.5	16.3	1.6	3.6	3.5	2.9	4.0
Overall health rating	2.1	4.6	6.7	1.6	2.1	2.6	2.0	2.3
Average weekly red wine intake	2.1	3.1	6.2	-2.5	-1.6	-0.6	-2.3	-1.0
Weight	1.9	9.4	15.4	1.8	3.1	3.6	2.3	3.9
Basal metabolic rate	1.9	10.3	15.8	1.6	3.6	3.6	2.8	4.0
Leg predicted mass (left)	1.8	9.5	14.8	1.7	3.4	3.4	2.6	3.8
Hip circumference	1.8	7.9	13.8	1.4	2.5	3.5	2.2	3.7
Breastfed as a baby	1.8	2.3	4.4	-1.3	-1.0	-1.3	-1.6	-2.1
Whole body water mass	1.8	10.2	15.1	1.4	3.7	3.5	2.8	3.9
Leg fat-free mass (left)	1.7	9.1	14.6	1.6	3.2	3.4	2.5	3.8
Trunk predicted mass	1.7	9.9	15.6	1.2	4.0	3.4	2.8	3.6
Standing height	1.7	16.7	32.7	1.7	5.7	3.9	4.0	4.1
Whole body fat-free mass	1.7	9.9	14.4	1.5	3.6	3.5	2.8	3.8
Number of self-reported non-cancer illnesses	1.7	2.9	5.2	1.2	1.5	2.3	1.1	2.1
Ever depressed for a whole week	1.7	2.1	3.2	-1.7	-1.4	-0.9	-1.8	-1.3
Hypothyroidism (self reported)	1.6	3.7	7.8	-1.4	-2.6	-0.5	-2.8	-1.3
Average weekly spirits intake	1.6	2.0	3.5	1.1	1.5	1.2	1.9	1.3
Trunk fat-free mass	1.6	9.4	14.7	1.2	3.8	3.3	2.7	3.5
Qualifications: A levels/AS levels or equivalent	1.6	3.5	7.0	0.4	-2.6	-2.2	-1.4	-1.9
Suffer from ‘nerves’	1.6	2.5	5.8	0.5	-1.3	-2.0	-1.1	-2.4
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.9	0.4	1.6	1.7	1.0	1.6
Ever had bowel cancer screening	1.6	1.8	2.8	-1.3	-0.8	-1.1	-1.6	-1.7
Financial situation satisfaction	1.6	1.9	4.0	0.8	1.7	2.0	1.1	1.1
Body Mass Index (BMI) (2010)	1.5	2.0	4.2	0.9	2.1	1.2	1.0	1.6
Illnesses of siblings	1.5	2.1	3.3	-1.0	-1.3	-1.8	-1.6	-1.4
Leg fat-free mass (right)	1.5	8.3	13.9	1.6	2.9	3.3	2.4	3.7
Leg predicted mass (right)	1.5	8.2	14.1	1.6	2.8	3.3	2.4	3.8
Pulse wave Arterial Stiffness index	1.4	1.7	3.5	-0.0	1.4	1.9	1.2	1.2
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.1	-1.7	-0.9	-1.2	-1.8	-1.0
Height	1.3	25.1	46.0	0.8	6.8	5.2	4.5	5.6
Medication: Co-codamol	1.3	1.6	4.2	0.1	-2.0	-0.9	-1.5	-0.7
Taking other prescription medications	1.3	2.0	3.7	1.8	1.1	1.1	0.8	1.9
Trunk fat mass	1.3	5.4	10.2	1.5	2.0	2.8	1.6	3.2
High blood pressure (siblings)	1.3	1.9	5.2	0.1	1.0	2.3	1.1	1.3
Neck or shoulder pain in last month	1.3	1.8	4.7	-1.2	1.6	2.2	0.7	0.3
Had major operations	1.3	1.6	2.2	1.5	1.4	0.6	1.4	1.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.6	0.1	-1.5	-1.9	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.7	-0.3	2.4	2.1	0.9	1.5
Age at First Birth	1.2	1.7	5.7	2.4	0.1	0.1	1.4	0.9
Nervous feelings	1.2	2.2	3.4	-1.9	-1.5	-1.4	-1.1	-1.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	5.3	-1.1	-1.9	-0.4	-2.3	-1.3
Whole body fat mass	1.2	5.1	9.1	1.7	1.9	2.7	1.6	3.0
Qualifications: nursing, teaching	1.2	1.9	3.3	-1.4	-1.1	-1.8	-0.8	-1.6
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	1.7	1.0	0.9	1.5	0.8
Wears glasses or contact lenses	1.2	1.4	3.1	0.1	-0.6	-1.4	-1.3	-1.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.9	2.2	0.4	0.0	0.9	0.9
Medication: Levothyroxine sodium	1.1	1.9	4.1	-1.0	-1.4	-0.9	-2.0	-1.1
Exposure to tobacco smoke outside home	1.1	1.5	2.3	-1.2	-1.5	-0.7	-1.2	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.2	-1.3	-1.2	-0.6	-1.5	-1.0
Ever smoked	1.1	1.9	4.1	1.4	2.0	1.2	1.1	0.7
Medication for hormone replacement therapy	1.0	1.1	3.1	1.7	1.2	0.8	0.4	0.1
Current tobacco smoking	1.0	1.7	2.2	1.5	1.5	1.2	1.4	0.6
Number of incorrect matches in round	1.0	1.6	3.1	0.3	1.6	1.8	1.3	0.7
Qualifications: None of the above	1.0	2.1	2.9	1.1	1.7	1.4	1.4	1.6
Time employed in main current job	1.0	1.2	2.5	1.6	0.2	0.9	0.8	1.3
Arm fat mass (right)	1.0	4.0	8.3	1.1	1.6	2.6	1.2	2.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.0	-0.7	-1.4	-1.3	-1.4	-0.3
Leg fat mass (right)	1.0	3.7	6.9	0.9	1.8	2.6	1.1	2.6
Mineral and other dietary supplements	1.0	1.3	2.4	1.6	0.5	1.4	1.2	0.8
Mother’s age at death	1.0	1.2	1.8	-0.4	-1.3	-0.9	-1.3	-1.2
Leg fat mass (left)	1.0	3.9	7.6	1.1	1.6	2.6	1.2	2.8
Neuroticism (2016)	0.9	1.3	4.5	-2.1	-0.6	0.3	-1.2	-0.6
Medication: Metformin	0.9	1.2	3.3	1.2	0.3	1.2	-0.1	1.8
Waist circumference	0.9	3.2	6.5	0.7	1.6	2.6	0.7	2.4
Forced vital capacity (FVC)	0.9	3.4	7.5	0.9	2.7	1.5	1.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.4	1.6	2.1	0.8	1.3	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	4.2	1.1	1.9	1.5	1.8	2.0
Forced vital capacity (FVC), Best measure	0.9	3.4	5.0	1.0	2.2	1.6	1.9	2.2
Medication: Omeprazole	0.9	1.0	3.4	0.5	0.7	0.5	0.9	1.8
Commuting to job workplace: Walk	0.9	1.0	1.9	-0.7	-0.7	-1.2	-1.4	-0.9
Osteoarthritis (self-reported)	0.9	1.2	3.6	0.1	1.0	1.9	0.9	0.9
Arm fat mass (left)	0.9	3.8	8.3	1.3	1.4	2.4	1.1	2.9
Medication: Bendroflumethiazide	0.9	1.4	2.5	-1.4	-1.1	-0.8	-1.6	-0.9
Illnesses of father: High blood pressure	0.9	1.2	1.8	0.3	1.0	1.2	1.2	1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.1	-1.7	-0.8	-1.1	-0.8	-2.0
Blood Red Count	0.8	7.2	9.3	-1.4	-2.6	-3.0	-3.0	-3.0
Smoking Status	0.8	1.9	2.8	1.7	1.6	1.5	0.7	1.0
Qualifications: CSEs or equivalent	0.8	1.0	2.6	1.6	1.3	0.8	0.4	0.1
Sitting height	0.8	5.4	10.8	-0.0	3.3	2.3	2.0	2.7
Happiness	0.8	0.9	3.0	-0.1	1.0	1.7	0.6	0.6
Noisy workplace	0.8	0.9	2.1	0.6	1.2	0.2	1.4	1.0
Health satisfaction	0.8	1.1	3.0	1.7	0.1	0.7	0.8	1.1
Medication: Allopurinol	0.8	1.1	3.9	-2.0	-0.7	-0.2	-1.0	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.6	-0.3	0.2	0.5	0.8	1.9
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.9	1.0	0.0	0.2	1.0	1.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	4.3	2.1	-0.2	0.0	0.5	-0.2
Commuting to job workplace: Public transport	0.8	1.0	2.3	-0.5	-1.5	-0.6	-0.8	-1.2
Worry (Nagel 2018)	0.7	1.6	2.9	-1.0	-1.2	-1.3	-0.9	-1.7
Ulcerative Colitis (UC)	0.7	1.4	2.0	-1.4	-1.3	-1.1	-1.1	-1.0
Rheumatoid Arthritis	0.7	0.9	2.3	1.5	0.6	-0.6	1.3	0.4
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	1.8	-0.0	-0.1	1.0	0.2
Angina	0.7	0.9	2.1	-1.5	-1.1	-0.2	-0.9	-0.1
Past tobacco smoking	0.7	1.3	3.1	-0.8	-1.8	-1.3	-0.4	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	-0.8	-0.9	-0.5	-1.3	-1.1
Alcohol intake versus 10 years previously	0.7	1.0	2.6	1.6	1.0	0.8	0.8	0.4
Peak expiratory flow (PEF)	0.7	1.6	3.5	-0.2	1.9	1.3	1.1	1.3
Medication: Paracetamol	0.7	1.1	2.1	1.1	0.9	0.9	0.7	1.5
Age at first live birth	0.7	1.2	2.8	-0.5	-1.4	-1.7	-0.9	-0.6
Heart disease (mother)	0.7	0.8	2.1	-1.4	-0.7	0.5	-0.6	-1.0
Number of full sisters	0.7	0.9	1.7	0.5	1.1	1.3	1.0	0.5
Knee pain experienced in last month	0.7	1.1	2.1	1.5	0.9	0.9	0.8	1.0
Breast cancer (self-reported)	0.7	0.9	2.4	0.6	-0.9	-1.6	-0.5	-0.6
Smoking status: Current	0.7	1.0	1.7	1.3	1.1	0.9	1.1	0.4
Alcohol drinker status: Previous	0.7	0.8	2.0	0.5	-1.1	-1.4	-0.2	-0.9
Bipolar Disorder (2018)	0.6	1.0	2.2	0.7	1.0	0.5	0.9	1.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	0.4	0.7	1.3	1.4	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	-0.2	-1.4	-0.8	-0.7	-0.6
Severe depression (siblings)	0.6	0.6	2.3	-0.8	1.5	0.4	-0.3	-0.1
Trunk fat percentage	0.6	2.5	5.9	1.1	0.9	2.0	0.8	2.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	-0.1	1.3	1.4	0.9	0.5
Hearing difficulty/problems with background noise	0.6	1.0	1.9	1.0	1.4	0.8	0.9	0.9
Birth weight of first child	0.6	1.2	1.7	1.3	1.2	1.0	0.9	1.0
Loud music exposure frequency	0.6	0.6	1.2	-1.1	-0.4	-0.5	-1.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-0.4	-1.2	-0.9	-0.7	-1.4
Number of children fathered	0.6	0.7	1.9	0.1	-0.6	-1.4	-0.4	-1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.4	1.2	0.6	0.0	0.6	1.1
Angina (self-reported)	0.6	0.8	2.1	-1.5	-1.0	-0.1	-0.8	-0.2
Migraine (self-reported)	0.6	0.8	1.7	1.3	0.8	0.7	1.0	-0.3
Age at last live birth	0.6	0.8	2.0	-0.4	-1.0	-1.4	-0.7	-0.7
Diabetes diagnosed by doctor	0.6	0.9	2.1	0.6	0.1	1.4	0.1	1.4
Eye problems/disorders: Cataract	0.6	0.7	2.0	-1.4	-0.4	0.2	-0.4	-0.9
Osteoporosis (self-reported)	0.6	0.7	1.5	0.9	0.8	0.7	1.2	0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-0.2	0.8	1.2	0.4	1.1
Alzheimer’s Disease (in father)	0.5	0.5	1.3	-0.3	1.2	1.0	0.5	0.2
Coronary Artery Disease (CAD)	0.5	0.6	2.5	-1.6	0.1	-0.6	-0.6	-0.1
Primary Biliary Cirrhosis	0.5	0.7	2.4	1.5	0.2	0.5	1.0	0.3
Ulcerative Colitis	0.5	0.7	1.2	-0.4	-0.8	-0.9	-1.1	-0.8
Supplements: Zinc	0.5	0.6	1.1	0.9	0.4	1.1	0.7	0.5
Diabetes (father)	0.5	0.6	1.0	0.4	1.0	0.5	1.0	0.9
Body mass index (BMI)	0.5	2.3	5.2	1.0	0.6	2.1	0.6	2.3
Heart attack	0.5	0.6	1.6	-1.3	-0.5	0.8	-0.8	-0.2
Medication: Ramipril	0.5	0.7	1.7	-0.4	-0.1	-0.9	-1.3	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.7	0.5	0.8	0.8	0.8	0.7
Medication: Lansoprazole	0.5	0.5	1.8	0.7	0.0	0.2	0.5	1.3
Exposure to tobacco smoke at home	0.5	0.6	1.1	0.8	0.8	1.0	0.4	0.6
Hair/balding pattern: Pattern 4	0.5	1.3	2.0	-0.8	-1.3	-1.3	-0.6	-1.4
Blood clot in the leg (DVT)	0.5	0.6	1.5	0.7	1.2	0.8	0.4	0.6
Gout (self-reported)	0.5	0.7	1.7	-1.3	-0.5	-0.0	-1.1	-0.7
Birth weight	0.5	1.1	1.9	0.9	1.4	0.5	1.1	1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-0.4	0.8	0.6	1.2	0.3
Body fat percentage	0.5	2.0	4.8	1.0	0.7	1.9	0.5	2.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.6	0.2	1.2	1.6	0.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	-0.7	-0.6	-1.2	-0.7	-0.4
Pulse wave peak to peak time	0.5	0.6	1.8	0.3	-0.7	-1.3	-0.7	-0.5
Smoking status: Previous	0.5	0.8	1.4	0.6	1.2	1.1	-0.1	1.0
Long-standing illness, disability or infirmity	0.5	0.7	2.7	0.3	0.5	1.6	0.1	0.7
Friendships satisfaction	0.5	0.6	1.8	-0.5	-0.4	-0.5	-0.8	-1.3
Ever taken oral contraceptive pill	0.5	0.5	1.7	-1.3	-0.8	-0.1	-0.5	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-1.1	-0.7	-1.1	-0.3	0.0
Alcohol drinker status: Never	0.5	0.6	1.0	-1.0	-1.0	0.6	-0.9	0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-1.2	0.7	0.8	0.4	0.5
Age started oral contraceptive pill	0.5	0.7	1.5	-1.2	-0.8	-0.4	-0.5	-0.8
Unable to work because of sickness or disability	0.5	0.6	1.7	0.6	0.3	1.3	-0.0	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	-0.3	0.4	0.3	0.6	1.5
Pain experienced in last month	0.5	0.8	1.5	-1.0	-1.2	-0.9	-0.8	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	0.0	1.2	0.3	0.8	0.7
Mean Putamen Volume	0.4	0.4	0.7	-0.8	-0.3	-0.1	-0.8	-0.9
Waist Hip Ratio (WHR)	0.4	2.0	3.4	-1.6	-0.8	-1.3	-1.8	-1.2
Systolic Blood Pressure	0.4	1.8	3.1	0.5	0.9	1.7	1.5	1.8
Hearing difficulty/problems: Yes	0.4	0.6	2.0	0.3	1.4	0.1	0.7	0.8
Fed-up feelings	0.4	0.7	2.2	0.7	0.8	0.4	1.5	0.2
Supplements: Glucosamine	0.4	0.6	1.2	-1.1	0.9	0.4	0.4	0.6
Alcohol usually taken with meals	0.4	0.6	1.1	0.1	1.0	1.0	0.1	0.9
Diabetes (self-reported)	0.4	0.7	1.8	0.5	0.3	1.3	0.1	1.1
Lung cancer (father)	0.4	0.5	1.9	-0.1	-0.0	1.4	-0.5	0.3
Length of working week for main job	0.4	0.5	1.9	-1.4	-0.2	0.5	-0.0	-0.3
Headache pain in last month	0.4	0.7	1.7	1.1	1.3	-0.4	0.5	-0.3
Medication: Ibuprofen	0.4	0.4	1.7	-0.4	1.3	0.5	0.2	-0.0
Medication: Seretide 50 evohaler	0.4	0.5	1.3	0.1	0.8	0.0	1.1	0.7
Mean time to correctly identify matches	0.4	0.7	1.2	1.0	0.9	-0.5	0.6	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.6	-1.3	-0.2	0.9	-0.5	-0.1
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	0.6	0.6	-0.0	0.7	0.7
Irritable Bowel Disease (IBD)	0.3	0.6	1.6	-0.3	-0.8	-1.3	-0.1	-0.9
Major Depression (MDD)	0.3	0.3	1.6	-1.2	-0.0	-0.2	-0.4	0.1
Reaction Time	0.3	0.6	1.1	0.7	1.0	-0.5	0.8	-0.5
Ovarian Cancer	0.3	0.5	1.2	-0.5	0.1	-0.8	-0.4	-1.1
Blood Eosinophil Count	0.3	2.5	7.9	-0.1	-1.5	-2.8	-1.0	-1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	-0.2	-0.3	1.3	-0.1	1.2
Lung FVC	0.3	1.4	2.4	-0.4	-1.0	-1.5	-1.5	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.2	-0.1	1.1	0.5	-0.1	-0.5
Vitamin and mineral supplements	0.3	0.4	1.5	0.2	-1.2	-0.2	-0.6	-0.5
Hand grip strength (right)	0.3	0.9	2.4	-0.7	1.6	0.7	0.9	0.6
Relative age voice broke	0.3	0.5	1.3	0.6	-1.1	-0.8	0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	1.2	1.0	0.3	0.7	0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.0	-0.5	-0.4	-0.4	-0.5	-1.0
Serious illness, injury or assault to yourself	0.3	0.3	0.8	0.8	-0.3	-0.9	-0.0	-0.2
Had other major operations	0.3	0.3	0.7	0.8	0.6	0.1	0.7	-0.3
Arm fat percentage (right)	0.3	1.0	2.6	0.6	0.1	1.5	-0.1	1.6
Father’s age at death	0.3	0.5	1.1	-1.0	-0.4	-0.6	-0.4	-0.7
Worrier / anxious feelings	0.3	0.6	1.0	-0.6	-0.4	-0.7	-1.0	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	0.0	0.5	1.4	0.6	0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.6	0.5	1.6	0.8	1.0	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	-0.5	1.1	0.5	0.3	0.2
Tense / ‘highly strung’	0.3	0.5	1.5	-0.3	0.7	1.2	0.4	0.5
Glaucoma (self-reported)	0.3	0.3	0.7	-0.5	0.0	-0.9	0.4	0.6
Medication: Amlodipine	0.3	0.4	0.6	-0.8	-0.6	-0.6	-0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	-1.0	0.3	0.6	-0.5	0.4
Leg fat percentage (right)	0.3	1.1	2.5	0.4	0.7	1.5	0.3	1.6
Number of full brothers	0.3	0.4	1.1	-0.7	-0.1	0.4	-1.1	-0.4
Alcohol intake frequency.	0.3	0.6	2.2	-0.0	-1.5	-0.4	-0.7	-0.5
Family relationship satisfaction	0.3	0.3	1.3	-0.4	1.1	-0.1	0.3	-0.1
Leg pain on walking	0.3	0.3	0.6	0.2	0.7	0.6	0.7	0.5
Illnesses of siblings: Diabetes	0.3	0.3	1.0	1.0	0.7	0.5	0.2	-0.0
Arm fat percentage (left)	0.3	1.2	3.2	0.9	-0.1	1.3	-0.1	1.8
Medication for cholesterol	0.3	0.4	1.1	-1.0	-0.0	-0.7	-0.1	-0.6
Miserableness	0.3	0.5	1.1	-0.6	-0.2	0.5	-1.0	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	0.6	0.3	0.9	0.4	0.6
Medication: Paracetamol	0.3	0.5	1.0	1.0	0.5	0.6	0.4	0.8
Medication: Atorvastatin	0.3	0.4	1.3	-0.4	-0.5	0.5	-0.4	1.1
Leg fat percentage (left)	0.3	1.2	2.9	0.5	0.5	1.6	0.3	1.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	-0.6	1.1	-0.2	0.1	0.1
Depression (Nagel 2018)	0.2	0.3	0.7	-0.5	0.5	0.8	0.1	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-0.8	0.5	-0.8	0.1	-1.0
Schizophrenia (2018)	0.2	0.3	1.1	-1.0	-0.0	0.4	-0.3	-0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	-0.7	-0.3	-0.4	-0.1	-1.0
Crohns Disease (2017)	0.2	0.5	1.3	0.8	0.6	-0.5	1.1	-0.1
LDL Cholesterol	0.2	0.3	0.9	-0.9	0.4	-0.2	-0.4	-0.3
Lupus	0.2	0.4	0.8	0.1	-0.4	-0.9	-0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.4	-0.5	0.8	-0.2	0.0
BMI	0.2	1.4	3.2	1.0	0.7	1.8	0.7	1.3
Allergy or Eczema	0.2	0.6	1.2	-0.2	-1.1	-1.0	-0.7	-0.4
Lung FEV1/FVC ratio	0.2	0.8	1.2	1.0	-0.8	-1.1	-1.0	-0.6
Relative age of first facial hair	0.2	0.3	0.9	-0.2	-0.6	-0.9	-0.5	-0.4
Systolic blood pressure, automated reading	0.2	0.7	1.5	0.4	0.2	1.2	0.7	1.2
Pack years adult smoking proportion	0.2	0.3	1.2	0.3	0.4	1.1	0.0	0.1
Maternal smoking around birth	0.2	0.2	0.5	0.2	0.2	0.5	0.5	0.7
Age when periods started (menarche)	0.2	0.4	1.6	1.3	-0.0	0.3	-0.2	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.3	-0.8	-0.7	-0.8	-0.5
Multivitamins +/- minerals	0.2	0.3	1.2	-0.2	1.1	0.2	-0.3	0.1
Stomach or abdominal pain in last month	0.2	0.3	1.0	-0.3	0.7	1.0	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	-0.3	0.9	0.1	0.6	0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	0.6	-0.6	-0.4	-0.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.7	-0.2	-0.5	-0.8	-0.3
Had menopause	0.2	0.3	0.5	-0.5	0.2	-0.7	-0.3	-0.6
Impedance of arm (right)	0.2	0.9	1.4	-0.9	-0.7	-1.0	-0.9	-1.2
Falls in the last year	0.2	0.2	0.3	0.2	0.6	0.6	0.6	0.2
Pulse rate	0.2	0.3	0.9	-0.4	-0.5	1.0	-0.4	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.1	0.8	0.6	0.8	-0.3
Prospective memory result	0.2	0.2	0.5	-0.5	0.7	0.4	-0.0	0.3
Impedance of arm (left)	0.2	1.0	2.0	-0.4	-1.1	-1.4	-1.0	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.8	-0.2	0.9	0.1	0.4
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.8	0.3	0.0	0.2	0.6
Supplements: Vitamin C	0.2	0.3	1.1	-1.0	-0.4	0.3	-0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.5	0.3	0.6	0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	0.1	-1.0	-0.1	-0.3	-0.4
Average weekly champagne plus white wine intake	0.2	0.2	0.9	-0.9	0.1	-0.5	-0.1	0.2
Guilty feelings	0.2	0.2	1.1	0.2	-0.0	1.1	-0.2	-0.1
High cholesterol (Self-reported)	0.2	0.4	0.7	0.8	0.1	0.6	0.3	0.8
Medication: Lisinopril	0.2	0.2	0.7	-0.3	-0.6	-0.1	-0.9	0.3
Diastolic blood pressure, automated reading	0.2	0.7	1.3	0.1	1.2	0.9	0.4	1.1
Myopia	0.2	0.3	0.6	0.1	0.7	0.6	0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	0.3	1.1	0.4	0.1	0.3
Heart disease (siblings)	0.2	0.2	0.5	-0.1	-0.5	-0.7	-0.4	-0.0
Pack years of smoking	0.2	0.3	1.5	0.2	0.2	1.2	-0.2	0.2
Impedance of whole body	0.2	0.8	1.3	-0.7	-0.6	-1.1	-0.7	-1.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	-0.3	0.6	0.7	0.4	0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.4	-0.5	-0.2	-0.7	-0.8
Breast Cancer	0.1	0.3	0.7	0.0	0.8	-0.7	0.6	-0.1
Fasting Glucose	0.1	0.1	0.3	-0.4	0.3	-0.1	-0.6	-0.2
HbA1C	0.1	0.1	0.3	-0.1	-0.6	-0.1	0.2	-0.4
HDL Cholesterol	0.1	0.1	0.3	0.5	0.2	-0.1	0.2	0.5
Schizophrenia (2014)	0.1	0.2	0.4	-0.5	0.3	0.6	-0.1	-0.1
Triglycerides	0.1	0.2	0.7	0.2	-0.2	-0.8	-0.1	-0.4
Blood White Count	0.1	0.8	1.5	0.1	-1.1	-0.1	-1.1	-1.2
Heel T-Score	0.1	0.6	1.6	0.9	1.2	0.2	0.9	0.4
Cardiovascular Disease	0.1	0.5	1.3	0.3	-0.5	1.1	0.0	0.9
Respiratory disease	0.1	0.3	0.7	-0.8	-0.1	0.8	0.3	0.5
Chronotype (morning person)	0.1	0.2	0.4	0.7	0.3	-0.4	0.3	0.5
Hair Pigment	0.1	2.3	4.7	0.1	1.0	2.2	1.2	2.1
Hand grip strength (left)	0.1	0.2	0.5	-0.4	0.7	0.4	0.3	0.2
Number of treatments/medications taken	0.1	0.1	0.2	0.5	0.4	0.4	0.1	0.4
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.6	-0.2	0.3	-0.5	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.3	0.3	0.0	0.4	0.1
Impedance of leg (right)	0.1	0.7	1.7	-1.0	0.2	-0.8	-0.5	-1.3
Average weekly fortified wine intake	0.1	0.2	0.4	0.3	-0.2	-0.3	0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.8	-0.2	0.4	-0.2	-0.1
High blood pressure	0.1	0.2	0.5	-0.2	-0.7	-0.1	-0.7	0.4
Impedance of leg (left)	0.1	0.7	1.4	-0.9	-0.4	-0.8	-0.6	-1.2
Mouth/teeth dental problems	0.1	0.1	0.4	-0.2	-0.0	0.6	0.1	0.5
Allergy	0.1	0.2	0.7	-0.5	0.2	-0.1	0.0	-0.9
Pain all over the body in last month	0.1	0.1	0.2	-0.2	0.5	0.2	0.1	-0.1
Medication: Simvastatin	0.1	0.1	0.1	0.4	-0.3	-0.2	-0.3	0.1
Fluid intelligence score	0.1	0.3	0.7	-0.8	-0.0	-0.5	-0.1	-0.8
Neuroticism score	0.1	0.1	0.4	-0.1	-0.1	0.5	-0.2	-0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.0	0.2	-0.3	0.8	0.4
Number of live births	0.1	0.1	0.4	0.1	-0.6	-0.3	-0.2	0.4
Asthma	0.1	0.2	0.5	-0.7	-0.3	0.2	-0.6	0.2
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.5	0.4
Pulse wave reflection index	0.1	0.1	0.2	-0.2	0.2	0.4	0.3	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.6	-0.6	-0.3	0.0	0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.1	-0.4	0.0	0.6	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	0.1	-0.0	0.2	0.8	0.5
Medication: Blood pressure	0.1	0.2	0.7	-0.2	0.4	0.0	-0.9	-0.3
Pulse rate, automated reading	0.1	0.2	0.3	-0.2	-0.4	0.5	-0.5	0.5
Hypertension (Self-reported)	0.1	0.3	0.5	-0.3	-0.7	0.3	-0.7	0.4
Mood swings	0.1	0.1	0.3	0.1	-0.4	0.5	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.6	0.4	-0.3	0.6	-0.0
Back pain experienced in last month	0.1	0.2	0.8	0.1	0.1	0.9	0.0	-0.1
Asthma (self-reported)	0.1	0.2	0.5	-0.7	-0.3	0.2	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	0.2	0.4	0.1	0.5	1.0
Hearing aid user	0.1	0.1	0.3	-0.5	-0.2	-0.2	-0.3	0.2
Medication: Blood pressure	0.1	0.2	0.5	-0.2	-0.7	0.2	-0.6	0.4
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.5	-0.3	-0.2	-0.6	-0.6
Risk taking	0.1	0.1	0.4	-0.2	-0.3	0.4	-0.7	0.0
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.3	-0.6	-0.3	-0.0	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.5	0.8	0.0	0.8	-0.0
Cholesterol lowering medication	0.1	0.2	0.4	-0.2	-0.5	0.3	-0.3	0.6
Supplements: Calcium	0.1	0.1	0.2	-0.0	-0.2	-0.4	0.1	-0.3
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.2	0.1	0.1	-0.5	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.2	-0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.5	1.0	0.1	-1.0	0.0	-1.0	-0.8
Neuroticism	0.0	0.1	0.3	-0.3	-0.2	0.3	-0.2	-0.6
Tanning	0.0	0.5	1.1	-1.0	-0.7	-0.3	-1.1	-0.2
Medication: Atenolol	0.0	0.0	0.1	0.1	0.1	0.2	-0.0	-0.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3	-0.3
Comparative body size at age 10	0.0	0.1	0.4	0.2	-0.7	0.0	-0.3	0.2
Loneliness, isolation	0.0	0.1	0.2	0.1	-0.2	0.0	-0.3	-0.4
Medication: Gliclazide	0.0	0.0	0.2	-0.1	0.1	-0.4	0.0	0.1

Hub : Genes

DACT2

Models

Trait associations