TWAS hub - SMOC2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.160	0.0360	1.9e-07	0.052	0.078	0.114	0.122	0.109	5.5e-07	1.0e-09	9.7e-14	1.1e-14	3.9e-13
2	GTEx	Artery Tibial	0.152	0.0484	6.5e-04	0.014	NA	0.004	NA	0.019	2.4e-02	NA	1.4e-01	NA	1.2e-02
3	GTEx	Esophagus Muscularis	0.177	0.0720	7.0e-03	-0.001	NA	0.000	NA	-0.005	4.0e-01	NA	3.3e-01	NA	8.7e-01
4	GTEx	Nerve Tibial	0.242	0.0645	1.4e-04	0.050	NA	0.032	NA	0.051	1.9e-04	NA	2.3e-03	NA	1.7e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.239	0.0395	2.0e-11	0.111	0.113	0.164	0.168	0.159	3.8e-14	2.6e-14	1.4e-20	5.5e-21	6.7e-20
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.103	0.0331	5.5e-05	0.044	0.028	0.010	NA	0.027	8.6e-06	3.3e-04	2.3e-02	NA	4.2e-04
7	TCGA	Brain Lower Grade Glioma	0.135	0.0408	8.0e-07	-0.001	0.053	0.049	NA	0.028	4.2e-01	1.2e-06	2.6e-06	NA	3.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7
Eye problems/disorders: Diabetes related eye disease	3.9	4.3	10.5	-3.2	-0.8	0.7	-3.2	-1.8	-2.2
Health satisfaction	3.0	3.9	7.5	-2.5	-2.4	-1.3	-2.7	-0.7	-2.5
Shortness of breath walking on level ground	3.0	3.6	13.4	-1.2	-3.7	-2.9	-1.0	0.2	-1.1
Pulse wave Arterial Stiffness index	2.6	3.0	7.3	2.6	1.0	-0.8	1.8	2.7	1.4
Pulse wave peak to peak time	2.3	2.7	6.8	-2.5	-0.9	0.6	-1.6	-2.6	-1.4
Medication: Co-codamol	2.2	2.5	4.1	-2.0	-1.4	-0.9	-1.9	-1.9	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	7.8	1.5	2.2	2.8	1.1	-0.2	1.6
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	5.8	1.3	2.4	0.5	1.9	2.1	1.1
Diabetes diagnosed by doctor	2.0	3.2	7.2	-2.6	-1.4	-0.4	-2.7	-0.6	-2.5
Fractured/broken bones in last 5 years	2.0	2.6	4.7	-1.8	-2.0	-1.4	-2.2	-1.8	-1.0
Diabetes (self-reported)	1.9	3.0	7.4	-2.7	-1.1	0.3	-2.7	-0.3	-2.2
Comparative height size at age 10	1.8	10.0	29.8	3.7	1.4	-4.4	5.5	2.0	1.0
High cholesterol (Self-reported)	1.8	3.3	9.5	-2.5	0.1	-0.6	-3.1	-1.8	-1.8
Tense / ‘highly strung’	1.7	2.8	6.6	-2.4	0.2	0.9	-2.6	-2.0	-1.3
Osteoporosis (self-reported)	1.7	2.1	6.3	-1.4	-2.5	-0.6	-1.5	-1.7	-0.8
Eye problems/disorders: None of the above	1.6	1.8	5.6	2.4	0.7	0.2	2.2	1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	11.1	1.9	0.8	-1.8	3.3	1.5	1.6
Financial situation satisfaction	1.6	1.9	4.3	-1.9	-1.0	-1.7	-1.3	-0.6	-2.1
Time employed in main current job	1.5	1.7	4.8	-1.9	-2.2	-0.7	-1.7	0.5	-0.1
Pulse wave reflection index	1.5	1.8	3.7	1.6	1.8	1.0	1.1	1.0	1.9
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.1	-2.3	-1.7	-0.5	-2.3	0.7	-2.1
Medication: Metformin	1.4	1.9	5.1	-2.2	-0.5	-0.0	-2.2	0.1	-1.8
Pack years adult smoking proportion	1.4	2.2	4.9	-2.0	-1.2	0.1	-2.2	-1.6	-1.5
Qualifications: A levels/AS levels or equivalent	1.4	3.2	8.3	-1.1	-2.1	-1.1	-1.7	-2.9	-2.1
Schizophrenia vs Biploar Disorder	1.3	1.7	3.7	-1.4	0.3	0.8	-1.7	-1.9	-1.6
Multivitamins +/- minerals	1.3	1.6	3.2	1.7	-1.2	-1.5	1.3	1.8	-0.1
Sitting height	1.3	9.2	38.8	1.9	-1.7	-6.2	4.2	1.2	0.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	4.8	-1.6	0.4	0.5	-1.4	1.2	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.4	-1.1	-2.1	-1.2	-1.3	-0.1	-1.6
Cholesterol lowering medication	1.3	1.9	6.1	-1.8	-0.4	0.2	-2.5	-1.6	-1.0
Triglycerides	1.2	1.9	3.9	1.4	1.4	2.0	1.0	1.2	1.8
Heel T-Score	1.2	9.7	17.6	4.2	3.1	3.6	3.0	2.5	3.5
Birth weight	1.2	2.5	5.6	2.2	1.1	-0.2	2.1	2.4	1.3
Long-standing illness, disability or infirmity	1.2	1.8	8.0	0.6	-1.6	-2.8	0.3	-0.2	-1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.9	1.4	1.7	0.1	1.6	0.9	1.3
Pack years of smoking	1.2	1.7	4.8	-1.7	-1.0	0.5	-2.2	-1.2	-1.3
Mouth/teeth dental problems: Dentures	1.1	1.9	5.4	1.5	2.3	1.7	1.3	1.1	0.4
Breastfed as a baby	1.1	1.3	3.2	1.2	0.6	1.2	0.9	1.4	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	6.3	-0.4	1.8	2.5	-0.4	-1.4	0.1
Age at first live birth	1.1	1.9	6.1	-0.2	-2.2	-2.5	-0.0	0.5	-1.5
Wears glasses or contact lenses	1.1	1.2	5.8	0.4	0.7	1.5	0.1	0.0	2.4
Eye problems/disorders: Glaucoma	1.1	1.3	3.9	-1.3	-2.0	-1.3	-0.8	-0.9	-0.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.6	1.9	0.3	1.1	1.2	0.7	1.4
Commuting to job workplace: Cycle	1.1	1.4	3.2	-1.4	-1.0	-0.6	-1.8	-0.3	-1.8
Mean Putamen Volume	1.0	1.2	2.3	-1.4	-0.9	-0.2	-1.5	-1.5	-1.0
Severe depression (siblings)	1.0	1.1	3.9	-0.4	2.0	1.5	-0.1	-0.0	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	6.1	1.6	1.6	2.5	1.2	0.6	1.6
Supplements: Vitamin C	1.0	1.2	3.5	-0.6	-1.9	-1.7	0.0	-0.4	-1.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.8	-1.7	-0.5	0.3	-1.7	-1.6	0.5
Alzheimer’s Disease (in mother)	0.9	1.0	2.9	0.9	0.4	1.7	0.4	1.2	1.4
Alzheimer’s Disease (in father)	0.9	1.0	3.9	-1.6	-0.2	-0.5	-2.0	-0.3	-0.7
Height	0.9	16.5	48.2	3.9	1.4	-6.9	6.8	1.7	-0.5
Sensitivity / hurt feelings	0.9	1.6	4.5	1.2	1.1	1.5	0.7	1.1	2.1
Hair/balding pattern: Pattern 2	0.9	1.1	3.3	-0.3	-1.2	-1.0	0.0	1.3	-1.8
Number of full brothers	0.9	1.2	4.2	-2.1	0.0	-0.0	-2.0	0.2	-0.3
Mean time to correctly identify matches	0.9	1.6	3.0	1.7	1.7	0.7	1.6	1.4	-0.5
Heart disease (mother)	0.9	1.1	4.2	-0.8	-1.6	-2.1	0.0	0.0	-0.7
Miserableness	0.9	1.6	3.2	1.8	1.1	0.8	1.8	1.2	1.3
Illnesses of father: High blood pressure	0.9	1.1	3.2	-1.1	0.7	0.2	-1.5	-1.8	-0.4
Age started oral contraceptive pill	0.9	1.1	4.9	0.4	0.7	1.0	0.1	2.2	-1.1
Vitamin and mineral supplements	0.8	1.1	2.2	-1.5	1.1	1.1	-1.3	-1.0	0.5
Stomach or abdominal pain in last month	0.8	1.0	3.1	0.2	1.7	1.8	0.2	-0.8	0.5
High blood pressure (mother)	0.8	1.1	4.9	1.0	-0.6	-0.1	0.9	0.6	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.2	0.8	2.0	2.0	0.5	-0.4	1.9
Mouth/teeth dental problems	0.8	1.2	2.6	-1.4	-1.6	-1.5	-1.2	-0.3	-0.2
Depression (self-reported)	0.8	1.0	3.2	-1.2	0.4	0.7	-1.1	-0.6	-1.8
Standing height	0.8	8.3	37.3	1.8	0.1	-6.1	4.0	1.2	-0.2
Exposure to tobacco smoke at home	0.8	0.9	1.8	-0.9	0.7	1.4	-1.1	-1.3	-0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.6	-1.3	1.6	0.9	-0.8	-0.5	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	0.9	-1.0	-1.6	1.3	-0.5	-0.4
Supplements: Calcium	0.8	0.9	3.6	0.4	-1.9	-1.5	0.4	0.0	0.3
Basal cell carcinoma (self-reported)	0.8	1.0	2.2	1.2	1.2	0.7	1.5	-0.9	0.4
Breast Cancer	0.7	1.6	3.3	-0.7	1.6	1.2	-0.8	1.8	1.8
Bipolar Disorder (2011)	0.7	0.7	1.8	1.3	-0.2	-1.3	1.0	0.5	-0.1
Had other major operations	0.7	0.9	2.2	-0.3	1.0	1.4	-0.3	-1.5	0.7
Medication: Ramipril	0.7	0.9	2.3	-0.4	-1.4	-1.5	-0.6	0.1	1.0
Falls in the last year	0.7	0.9	2.4	-1.6	-0.8	-0.6	-1.5	0.1	-1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	-1.1	0.9	1.3	-1.2	-0.8	-0.1
Medication: Omeprazole	0.7	0.9	2.7	0.8	-0.9	-1.7	1.2	-0.2	-0.6
Breast cancer (self-reported)	0.7	0.9	2.7	-1.0	0.7	0.7	-1.1	0.4	-1.6
Osteoarthritis (self-reported)	0.7	0.9	2.0	-1.2	-1.0	-0.7	-1.4	-1.0	-0.8
Hearing aid user	0.7	0.8	2.8	-0.8	-1.7	-0.8	-1.2	-0.4	-0.3
Medication: Bendroflumethiazide	0.7	1.0	3.0	0.4	0.9	1.7	0.5	-1.2	1.2
Medication: Atorvastatin	0.7	0.8	2.5	1.6	-0.1	-1.0	1.0	-0.2	1.1
Systolic Blood Pressure	0.6	3.1	8.9	-2.2	-2.4	-3.0	-1.4	-0.2	-0.1
Lung FEV1/FVC ratio	0.6	3.0	12.2	0.5	2.6	3.5	-0.4	0.9	0.6
Hand grip strength (left)	0.6	1.6	7.7	-0.9	2.8	1.3	-0.7	0.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.4	1.3	0.3	-0.7	1.5	0.2	0.9
Hand grip strength (right)	0.6	1.7	9.1	-0.3	3.0	1.3	0.3	0.7	0.8
Townsend deprivation index at recruitment	0.6	0.9	2.8	-1.3	-1.7	-1.1	-0.6	-0.3	-0.5
Average weekly fortified wine intake	0.6	0.7	3.2	0.0	-0.7	-0.9	0.3	1.8	-0.5
Number of incorrect matches in round	0.6	1.0	2.3	1.4	-0.2	-1.0	1.5	1.2	0.7
Financial difficulties in last 2 years	0.6	0.8	2.9	0.3	-0.1	-1.7	0.5	-1.1	-1.0
Medication: Simvastatin	0.6	0.8	2.3	-1.5	0.5	-0.0	-1.4	-0.7	-0.9
Father’s age at death	0.6	0.8	2.6	0.4	-1.5	-1.6	0.7	0.5	-0.2
Noisy workplace	0.6	0.7	2.5	0.1	1.3	0.8	-0.3	1.6	0.2
Birth weight of first child	0.6	1.0	3.9	1.7	0.4	-0.2	2.0	0.0	0.5
Blood clot in the leg (DVT)	0.6	0.8	1.7	-1.0	1.1	1.3	-0.9	-0.5	0.7
Gout (self-reported)	0.6	0.8	1.6	0.8	0.9	-0.1	1.2	1.3	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.3	0.7	0.2	-0.3	1.2	1.8	0.0
Forced vital capacity (FVC), Best measure	0.6	2.1	7.7	0.7	-0.5	-2.8	2.0	1.2	-0.8
Exposure to tobacco smoke outside home	0.6	0.8	3.6	0.8	1.9	0.3	-0.3	1.1	-0.0
Migraine (self-reported)	0.6	0.8	1.7	1.3	0.8	1.1	0.7	-0.1	1.2
Number of full sisters	0.6	0.7	1.4	0.8	1.0	1.2	0.8	-0.2	1.2
Illnesses of father: Heart disease	0.6	0.9	2.0	-1.4	-1.2	-1.0	-0.7	-0.3	-1.1
Medication: Gliclazide	0.6	0.7	2.4	-0.6	-0.7	-0.7	-0.8	1.5	-0.5
Number of self-reported non-cancer illnesses	0.6	1.1	3.0	-1.7	-0.8	-0.1	-1.7	-1.1	-0.5
Guilty feelings	0.6	0.9	2.3	-1.1	1.5	0.9	-1.0	-0.8	-0.7
Alcohol drinker status: Never	0.6	0.7	1.5	-0.9	-0.8	-0.4	-1.2	-0.3	-1.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	1.5	1.0	0.1	1.1	0.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.8	-0.9	1.2	1.3	-0.6	-0.2	0.7
Heart disease (siblings)	0.6	0.7	2.8	-0.8	-0.4	-0.0	-1.1	-0.2	-1.7
Alcohol drinker status: Previous	0.6	0.6	2.5	-0.6	0.7	1.6	-1.0	0.4	-0.2
Fasting Glucose	0.5	0.6	2.4	-0.8	0.1	-0.7	-0.7	-1.6	0.1
Rheumatoid Arthritis	0.5	0.6	2.4	0.2	-0.8	-1.0	0.4	1.5	-0.2
Ulcerative Colitis	0.5	0.8	1.8	-1.0	-1.1	0.1	-1.3	0.2	-1.2
Systolic blood pressure, automated reading	0.5	1.6	3.5	-1.7	-1.9	-1.5	-1.1	1.0	-0.2
Diabetes (father)	0.5	0.6	1.0	0.6	0.9	0.7	0.9	-0.8	1.0
Maternal smoking around birth	0.5	0.8	2.0	0.9	1.4	0.2	0.6	1.0	1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.2	0.8	0.8	1.0	1.1	-0.2	1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.3	1.1	1.1	0.2	0.5	0.9	0.6
Nervous feelings	0.5	0.9	2.0	0.3	-1.2	-1.1	0.1	1.4	-1.1
Hearing difficulty/problems with background noise	0.5	0.7	2.1	0.6	1.3	0.9	0.1	1.5	0.3
Heart attack	0.5	0.7	1.9	1.4	1.1	0.2	0.9	-0.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	1.3	-0.2	0.1	1.0	1.0	0.8
Length of working week for main job	0.5	0.5	1.7	0.5	0.4	0.1	1.3	-0.9	0.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.5	-0.7	-0.6	-0.6	-1.5	-0.4	-1.9
High blood pressure (siblings)	0.5	0.7	1.6	-1.3	-0.1	1.0	-1.2	-0.8	-0.6
Leg fat-free mass (right)	0.5	2.6	15.4	0.0	-1.1	-3.9	1.1	-0.1	-0.7
Ever had bowel cancer screening	0.5	0.6	1.2	1.0	0.5	0.4	1.1	1.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.4	0.7	0.9	1.8	0.6	0.6	0.2
Leg predicted mass (right)	0.5	2.5	15.0	0.0	-1.0	-3.9	1.2	-0.1	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.8	-1.3	-0.6	-0.0	-0.9	-0.4	-1.1
Diastolic blood pressure, automated reading	0.5	1.4	4.9	1.0	0.2	-0.0	1.6	1.3	2.2
Bipolar Disorder (2018)	0.4	0.7	1.6	1.2	0.2	-1.3	0.8	1.0	0.4
Schizophrenia (2018)	0.4	0.7	4.3	-0.3	-0.3	0.1	0.0	-2.1	-0.9
Ulcerative Colitis (UC)	0.4	0.7	1.8	-0.7	-0.9	0.5	-1.1	0.3	-1.3
Major Depression (MDD)	0.4	0.4	1.4	0.3	1.1	1.2	-0.4	-0.1	-0.4
Reaction Time	0.4	0.8	1.9	1.1	1.4	0.3	1.0	0.6	-0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	1.2	-0.2	-1.1	0.9	1.2	1.1
Ovarian Cancer	0.4	0.6	2.4	0.3	1.6	0.8	-0.1	-0.6	0.6
Body Mass Index (BMI) (2010)	0.4	0.5	1.6	-0.9	0.0	0.9	-0.5	-0.2	1.3
HDL Cholesterol	0.4	0.6	1.6	-1.0	0.4	0.5	-0.8	-1.2	-0.7
Neuroticism (2016)	0.4	0.6	1.6	0.6	1.2	1.3	0.6	0.1	0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.1	0.6	0.8	-0.3	0.5	1.5	-0.1
Blood Eosinophil Count	0.4	3.3	7.9	-2.8	0.8	-0.4	-2.6	-1.5	-2.3
Blood White Count	0.4	2.9	7.6	-1.6	-2.1	-2.7	-1.6	-0.9	-1.5
Cardiovascular Disease	0.4	1.2	3.5	-0.5	-1.3	-1.9	-0.6	-1.7	-0.3
Hypothyroidism (self reported)	0.4	0.8	2.2	-0.5	-0.9	-0.9	-1.3	-0.5	-1.5
Respiratory disease	0.4	1.0	2.6	1.1	-0.1	-0.8	1.3	1.6	0.7
Neuroticism	0.4	0.9	2.3	-1.3	0.6	1.3	-1.5	-0.8	0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	0.8	0.9	0.1	1.1	0.2	0.9
Medication for hormone replacement therapy	0.4	0.5	1.3	-0.0	-1.2	-0.9	0.2	-1.1	0.0
Supplements: Zinc	0.4	0.4	1.6	-0.1	-0.0	0.1	-1.1	0.0	-1.3
Impedance of leg (right)	0.4	1.8	4.0	1.3	2.0	1.7	1.0	0.2	1.6
Leg fat-free mass (left)	0.4	2.4	13.8	0.0	-1.1	-3.7	1.2	-0.1	-0.4
Age when periods started (menarche)	0.4	1.0	2.8	-1.1	0.5	1.7	-0.9	-1.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.1	-0.5	-1.5	-0.0	-0.3	-0.4	0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	1.4	-0.2	1.2	0.7	-0.4	0.3	-0.9
Leg predicted mass (left)	0.4	2.2	13.1	0.0	-0.9	-3.6	1.2	-0.1	-0.3
Forced vital capacity (FVC)	0.4	1.7	6.1	0.7	-0.3	-2.5	1.9	1.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.6	0.2	0.6	0.6	0.2	1.6	-0.3
Qualifications: None of the above	0.4	0.8	3.0	0.5	-1.1	-0.8	0.5	1.7	0.3
Trunk fat-free mass	0.4	2.3	6.9	1.2	0.2	-2.6	2.6	0.9	-0.0
Alcohol intake versus 10 years previously	0.4	0.5	1.5	0.2	-0.7	-1.2	-0.3	0.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.7	1.6	1.0	0.4	0.6	0.6	0.7
Pulse rate	0.4	0.7	2.0	0.6	-1.4	-1.3	0.4	1.0	-0.1
Happiness	0.4	0.4	1.3	0.5	-0.8	-1.1	0.8	0.4	0.2
Medication: Lansoprazole	0.4	0.4	1.5	-1.2	-0.2	-0.1	-0.9	-0.8	-0.0
Illnesses of mother	0.4	0.5	1.5	-0.5	-0.5	-0.7	-0.1	-1.0	-1.2
Trunk predicted mass	0.4	2.4	7.6	1.4	0.2	-2.6	2.8	1.0	0.1
Peak expiratory flow (PEF)	0.4	0.9	2.0	0.8	1.4	-0.1	0.8	-1.3	1.0
Headache pain in last month	0.4	0.7	2.3	0.6	1.3	1.5	0.9	0.1	0.2
Medication: Amlodipine	0.4	0.5	2.5	-0.3	-1.6	0.1	-0.5	-0.8	-0.6
Leg fat percentage (right)	0.4	1.3	2.7	-0.5	1.3	1.6	-1.3	-1.3	0.9
Suffer from ‘nerves’	0.4	0.6	2.0	-1.3	-0.3	0.1	-1.4	-0.2	-0.1
Overall health rating	0.4	0.8	1.7	-1.2	-1.3	-0.9	-1.1	-0.6	-0.7
Age at last live birth	0.4	0.5	2.4	0.3	-0.2	-0.8	0.2	0.6	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	-0.6	1.2	-0.4	-0.6	-1.2	0.2
Whole body fat-free mass	0.4	2.1	9.6	0.7	-0.3	-3.1	2.0	0.4	-0.3
Arm fat percentage (left)	0.4	1.5	4.5	-1.6	-0.2	0.1	-2.1	-1.8	-0.1
Qualifications: nursing, teaching	0.4	0.6	1.7	-0.8	0.4	0.8	-1.3	-0.6	-1.0
Eye problems/disorders: Cataract	0.4	0.5	1.5	-0.8	-1.2	-0.7	-0.6	-0.3	-0.6
Medication for cholesterol	0.4	0.6	1.7	0.8	0.6	-0.3	1.3	0.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.2	-0.1	0.8	-1.0	-1.0	-0.6
Smoking status: Current	0.4	0.7	1.7	1.3	1.1	0.0	0.6	1.2	-0.0
Whole body water mass	0.4	2.1	9.8	0.8	-0.3	-3.1	2.0	0.4	-0.3
Average weekly champagne plus white wine intake	0.4	0.5	1.6	-1.3	-1.1	-0.4	0.1	-0.9	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.8	-0.6	-0.3	-0.0	-0.6	0.6	-1.7
Medication: Lisinopril	0.4	0.5	1.7	0.5	-0.6	-0.9	0.5	0.2	-1.3
Ever smoked	0.4	0.7	2.4	0.4	1.1	0.7	0.8	-0.4	1.6
Leg fat percentage (left)	0.4	1.4	2.9	-0.7	1.3	1.6	-1.7	-1.5	0.4
Average weekly beer plus cider intake	0.4	0.6	2.5	-1.6	0.3	-0.1	-1.3	0.1	0.2
Depressed Affect (Nagel 2018)	0.3	0.7	2.3	0.4	0.8	1.0	0.6	0.4	1.5
Worry (Nagel 2018)	0.3	0.6	1.6	-0.9	0.8	0.9	-1.3	0.0	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	1.9	-0.0	0.9	1.4	-0.6	-0.1	0.7
Age at First Birth	0.3	0.4	1.0	-0.5	-1.0	-0.9	-0.3	-0.3	-0.7
Coronary Artery Disease (CAD)	0.3	0.4	1.7	0.7	0.8	0.1	0.3	1.3	0.0
Crohns Disease (2012)	0.3	0.5	1.4	0.1	-1.1	-1.2	0.1	0.7	-0.1
Lupus	0.3	0.4	0.9	-0.6	1.0	0.2	-0.9	-0.4	-1.0
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.9	-0.7	0.1	-1.0	-0.3	0.4
Schizophrenia (2014)	0.3	0.6	1.6	-0.7	-0.2	-0.5	-0.7	-1.3	-1.2
Waist Hip Ratio (WHR)	0.3	1.2	7.0	-0.4	-0.8	-2.6	0.0	-0.3	-0.5
Average weekly spirits intake	0.3	0.3	1.3	-0.1	1.1	0.9	0.5	-0.3	-0.2
Diabetes (mother)	0.3	0.4	1.5	-0.8	0.2	0.1	-1.2	0.6	-0.2
Trunk fat percentage	0.3	1.2	3.3	-1.4	0.0	-0.7	-1.7	-1.8	-0.0
Current tobacco smoking	0.3	0.4	1.3	1.0	0.9	-0.2	0.4	1.1	0.0
Relative age voice broke	0.3	0.4	1.8	-0.6	-1.3	-0.2	-0.7	0.6	-0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	1.0	1.3	0.1	1.2	0.1	0.1
Medication: Atenolol	0.3	0.3	1.5	0.7	1.2	0.1	0.5	0.4	-0.1
Impedance of leg (left)	0.3	1.4	4.4	1.1	2.1	1.7	0.6	-0.2	1.0
Waist circumference	0.3	1.2	3.0	-1.2	-0.3	-1.7	-1.0	-1.6	-0.7
Past tobacco smoking	0.3	0.5	2.4	-0.4	-0.2	0.2	-0.9	0.3	-1.5
Alcohol usually taken with meals	0.3	0.5	1.3	-1.1	-0.9	0.7	-0.8	-0.6	0.3
Had menopause	0.3	0.3	1.2	-0.7	-1.1	-0.3	-0.3	0.7	-0.2
Pain all over the body in last month	0.3	0.3	1.0	0.6	-0.2	-1.0	-0.1	0.0	-0.8
Neuroticism score	0.3	0.5	1.6	-0.5	1.1	1.3	-0.7	-0.4	0.3
Worrier / anxious feelings	0.3	0.6	2.0	-0.6	1.4	0.3	-0.7	-0.9	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	1.0	0.8	0.8	0.3	-0.9	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	-0.7	-0.2	0.6	-0.4	-1.2	-0.3
Glaucoma (self-reported)	0.3	0.3	0.6	-0.7	-0.8	-0.4	-0.6	-0.7	0.4
Body fat percentage	0.3	1.2	3.6	-1.2	0.3	0.1	-1.7	-1.9	0.2
Comparative body size at age 10	0.3	0.8	1.9	0.8	0.8	1.4	0.5	0.9	1.2
Medication: Ibuprofen	0.3	0.3	1.1	-0.5	-0.5	0.6	-1.1	0.2	0.3
Medication: Allopurinol	0.3	0.4	1.7	0.5	0.5	0.0	0.7	1.3	0.3
Alcohol intake frequency.	0.3	0.6	3.4	-0.5	-0.2	0.3	-0.8	-0.2	-1.8
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	0.8	-0.7	-0.6	0.5	-0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	-0.3	0.3	0.7	-0.8	-0.8	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	2.0	0.0	-0.3	1.4	-0.2	0.6	0.6
Smoking status: Previous	0.3	0.4	0.8	-0.2	-0.9	-0.9	0.5	-0.5	0.9
Loneliness, isolation	0.3	0.4	1.1	-0.9	1.1	0.5	-0.5	0.3	-0.3
Commuting to job workplace: Walk	0.3	0.4	1.6	0.1	-0.2	-0.2	-0.4	-1.3	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.6	-0.1	0.7	0.4	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	-0.9	-0.2	-0.1	-0.8	1.2	-1.3
Ever taken oral contraceptive pill	0.3	0.3	1.6	0.7	-0.2	0.1	-0.1	-1.2	0.6
Mother’s age at death	0.3	0.3	1.0	0.7	-0.0	-1.0	0.7	-0.5	-0.4
Basal metabolic rate	0.3	1.7	9.0	0.5	-0.3	-3.0	1.6	0.1	-0.2
Arm fat-free mass (left)	0.3	1.5	5.1	1.2	0.5	-1.8	2.3	0.5	0.2
Ever depressed for a whole week	0.3	0.4	1.9	0.1	-0.4	0.1	-0.2	1.4	-0.8
Unable to work because of sickness or disability	0.3	0.4	2.5	0.3	0.2	-1.6	0.5	-0.3	0.2
Myopia	0.3	0.4	1.1	0.8	0.2	-0.7	1.1	0.2	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.0	-1.0	-0.3	-0.6	-1.4	-0.3	-0.2
Crohns Disease (2017)	0.2	0.5	1.2	1.1	0.7	0.6	1.1	0.7	0.5
LDL Cholesterol	0.2	0.3	0.9	-0.2	0.7	0.9	0.4	0.3	0.9
Blood Red Count	0.2	1.5	4.2	0.7	-0.9	-2.1	0.7	2.0	0.5
Allergy or Eczema	0.2	0.5	1.7	0.9	0.9	-0.5	1.3	0.4	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.9	0.6	-0.1	0.6	0.2	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.9	0.3	0.2	-0.8	0.7	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.1	-0.3	0.5	-0.3	0.8	0.4
Fed-up feelings	0.2	0.4	1.2	0.1	1.1	0.6	0.8	0.4	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.5	-0.3	0.5	-0.8	-0.2	0.1
High blood pressure	0.2	0.4	1.0	-0.8	-0.5	-0.3	-1.0	-0.9	-0.6
Medication: Levothyroxine sodium	0.2	0.4	1.1	-0.5	-0.5	-0.1	-1.1	-0.4	-1.0
Body mass index (BMI)	0.2	0.8	2.3	-1.1	0.1	0.8	-1.5	-1.3	0.0
Allergy	0.2	0.4	1.5	-0.4	-1.2	-0.6	-0.6	-0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.2	0.2	-0.5	-0.1	-0.2	-1.1	0.4
Illnesses of siblings	0.2	0.3	1.7	0.3	-0.2	-1.3	0.7	-0.1	0.1
Arm fat percentage (right)	0.2	0.9	2.8	-1.1	-0.1	0.1	-1.7	-1.4	0.2
Number of live births	0.2	0.2	0.7	0.5	0.2	0.7	0.4	0.9	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	0.7	0.0	0.9	-0.1	0.5	0.8
Prospective memory result	0.2	0.3	0.8	-0.1	-0.9	0.5	-0.2	0.4	0.8
Lung cancer (father)	0.2	0.2	0.5	-0.3	-0.4	-0.3	-0.6	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.1	0.5	0.1	-1.1	1.5	1.0	-0.2
Impedance of arm (left)	0.2	0.9	3.0	-1.2	-0.8	-1.7	-1.0	-0.6	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.8	0.8	0.4	-0.6	-0.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.5	0.2	-0.8	0.3	-0.7	-0.8
Medication: Paracetamol	0.2	0.3	1.3	0.3	1.1	0.8	0.3	0.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.4	-0.9	-0.1	0.2	0.9	-0.5
Arm fat-free mass (right)	0.2	1.2	3.8	0.7	0.5	-1.9	1.9	0.2	-0.2
Number of children fathered	0.2	0.2	0.9	-0.0	0.4	0.9	-0.8	0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.6	-0.0	-1.0	-0.0	-0.1	-0.3
Emphysema/chronic bronchitis	0.2	0.2	1.1	0.1	-0.5	0.5	0.0	1.1	0.2
Neck or shoulder pain in last month	0.2	0.3	1.0	0.4	0.5	0.8	0.2	0.1	1.0
Medication: Blood pressure	0.2	0.3	1.6	0.2	0.7	0.5	-0.2	-1.3	-0.1
Medication: Seretide 50 evohaler	0.2	0.3	0.9	0.4	-0.2	-0.8	0.9	0.1	-0.4
Arm predicted mass (right)	0.2	1.1	4.4	0.7	0.4	-2.1	1.7	0.1	-0.2
Chest pain or discomfort	0.2	0.3	1.9	0.5	-0.0	0.2	0.3	-0.2	1.4
Had major operations	0.2	0.2	0.6	0.3	0.5	0.6	-0.1	0.5	-0.8
Family relationship satisfaction	0.2	0.2	0.3	0.4	-0.6	0.4	0.5	-0.6	0.4
Leg pain on walking	0.2	0.3	0.9	0.1	-0.6	-1.0	0.3	0.6	0.3
Medication: Aspirin	0.2	0.2	0.9	0.6	0.9	0.1	0.1	-0.2	0.5
Knee pain experienced in last month	0.2	0.3	0.8	-0.4	0.2	-0.6	-0.3	-0.7	0.9
Hypertension (Self-reported)	0.2	0.5	1.6	-0.6	-0.2	0.3	-1.1	-1.3	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.8	0.3	-1.4	-0.0	0.1	-0.2	0.2
Friendships satisfaction	0.2	0.2	1.0	-0.3	0.2	1.0	-0.1	0.4	0.4
Mineral and other dietary supplements	0.2	0.2	0.9	-0.3	0.1	0.3	0.1	-1.0	0.7
Number of operations (self-reported)	0.2	0.3	0.5	-0.4	0.7	0.7	-0.5	-0.6	-0.5
Risk taking	0.2	0.3	0.7	-0.5	-0.2	0.2	-0.7	-0.9	0.6
Pain experienced in last month	0.2	0.3	0.9	-0.5	-1.0	-0.6	-0.6	-0.4	-0.6
Arm predicted mass (left)	0.2	1.0	3.5	0.8	0.4	-1.6	1.9	0.2	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.5	-0.1	-0.7	0.5	-1.0	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.6	0.2	0.6	-0.8	-0.3	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.1	-0.1	0.6	-0.1	0.6	-0.7
HbA1C	0.1	0.1	0.4	-0.3	0.7	-0.4	-0.1	0.5	-0.2
Blood Platelet Count	0.1	1.5	3.2	-1.8	-0.7	-0.5	-1.8	-1.1	-1.5
BMI	0.1	0.5	1.5	-0.8	0.2	0.5	-1.2	-0.9	0.5
Smoking Status	0.1	0.3	1.5	0.5	-0.6	-1.2	0.2	0.4	-0.2
Lung FVC	0.1	0.6	2.3	-0.8	-1.0	-0.2	-0.3	1.5	0.3
Chronotype (morning person)	0.1	0.2	1.2	-0.2	0.2	1.1	-0.0	0.5	-0.1
Tanning	0.1	1.1	2.4	-1.5	-1.6	-0.8	-1.4	-0.2	-0.3
Number of treatments/medications taken	0.1	0.1	0.5	-0.1	-0.0	-0.2	-0.7	-0.4	-0.4
Relative age of first facial hair	0.1	0.2	0.6	-0.7	-0.3	0.4	-0.8	-0.3	0.1
Angina	0.1	0.2	0.7	0.4	-0.0	-0.4	-0.2	0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.2	0.2	0.1	-0.4	-0.2	-0.4
Taking other prescription medications	0.1	0.2	1.0	-0.0	-0.1	-1.0	-0.1	0.2	-0.5
Trunk fat mass	0.1	0.6	2.0	-0.7	0.3	-1.1	-0.6	-1.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.5	0.6	-0.1	0.1	-0.4	-0.3
Fluid intelligence score	0.1	0.1	0.3	-0.4	-0.1	-0.5	-0.3	0.5	0.2
Weight	0.1	0.7	3.8	-0.3	0.2	-2.0	0.3	-0.8	-0.1
Impedance of arm (right)	0.1	0.5	3.1	-0.2	-0.7	-1.8	-0.1	0.0	0.4
Hip circumference	0.1	0.6	1.7	-0.7	0.4	-1.0	-0.6	-1.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.5	0.3	0.4	-1.2	1.2	0.5	-0.1
Asthma	0.1	0.2	0.6	0.2	0.6	0.1	0.4	0.8	-0.6
Medication: Cholesterol lowering	0.1	0.2	0.8	-0.1	0.9	-0.5	-0.5	-0.5	-0.4
Arm fat mass (right)	0.1	0.3	1.3	-0.4	0.1	-0.4	-0.5	-1.1	0.3
Loud music exposure frequency	0.1	0.1	0.4	-0.4	-0.4	-0.4	-0.2	0.0	-0.7
Worry too long after embarrassment	0.1	0.2	0.6	-0.4	-0.2	0.3	-0.8	0.3	-0.3
Wheeze or whistling in the chest in last year	0.1	0.3	0.7	-0.3	0.5	0.8	-0.5	-0.5	0.6
Qualifications: College or University degree	0.1	0.2	0.6	-0.4	-0.3	0.4	-0.5	0.8	0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.6	-0.5	-0.3	0.3	-0.1	-0.6
Angina (self-reported)	0.1	0.1	0.6	0.4	0.1	-0.3	-0.2	0.2	-0.8
Whole body fat mass	0.1	0.5	1.6	-0.7	0.4	-0.7	-0.7	-1.3	0.3
Leg fat mass (right)	0.1	0.4	1.2	-0.1	0.9	0.2	-0.3	-1.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.8	-0.6	-0.9	-0.2	0.1	0.1	-0.2
Average weekly red wine intake	0.1	0.1	0.4	0.1	-0.5	-0.7	0.2	0.1	-0.1
Mood swings	0.1	0.2	0.8	0.0	0.5	0.6	-0.3	-0.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.1	-0.1	0.5	0.4	-0.1	0.4
Back pain experienced in last month	0.1	0.1	0.2	0.3	0.5	-0.0	0.4	-0.4	0.2
Asthma (self-reported)	0.1	0.3	1.1	0.5	0.5	-0.1	0.7	1.0	-0.1
Arm fat mass (left)	0.1	0.5	1.9	-0.8	-0.0	-0.7	-0.7	-1.4	0.0
Medication: Blood pressure	0.1	0.2	0.4	-0.4	-0.6	0.6	-0.6	0.3	-0.3
Medication: Paracetamol	0.1	0.2	0.4	-0.6	0.2	-0.2	-0.5	0.6	-0.7
Irritability	0.1	0.2	0.7	-0.5	-0.5	0.1	-0.4	-0.9	0.3
Leg fat mass (left)	0.1	0.4	1.5	-0.3	0.9	0.1	-0.6	-1.2	0.3
Depression (Nagel 2018)	0.0	0.1	0.3	-0.3	0.0	-0.2	-0.6	0.0	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	4.8	-0.5	-0.3	-0.2	-1.2	-0.4	-2.2
Supplements: Glucosamine	0.0	0.1	0.2	-0.0	-0.4	-0.3	-0.0	0.4	-0.2
Pulse rate, automated reading	0.0	0.1	0.2	-0.4	-0.1	-0.1	-0.1	0.3	-0.4
Medication: Aspirin	0.0	0.1	0.1	0.3	0.3	-0.4	-0.1	-0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.1	-0.2	0.2	0.3	0.7	-0.4
Impedance of whole body	0.0	0.1	0.2	-0.2	0.5	-0.4	-0.2	-0.3	0.3

Hub : Genes

SMOC2

Models

Trait associations