Hub : Genes

AL391319.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.142 0.0495 0.00089 0.005 NA 0.018 NA 0.017 1.1e-01 NA 1.3e-02 NA 1.5e-02
2 GTEx Esophagus Muscularis 0.200 0.0730 0.00240 -0.001 NA 0.005 NA -0.005 3.8e-01 NA 1.4e-01 NA 8.9e-01
3 GTEx Lung 0.124 0.0475 0.00470 -0.003 NA 0.002 NA 0.003 7.6e-01 NA 2.0e-01 NA 1.7e-01
4 GTEx Nerve Tibial 0.196 0.0570 0.00032 0.044 NA 0.040 NA 0.055 4.6e-04 NA 8.1e-04 NA 9.5e-05
5 GTEx Pancreas 0.201 0.0710 0.00830 -0.006 NA -0.005 NA -0.006 6.9e-01 NA 6.0e-01 NA 7.7e-01
6 GTEx Thyroid 0.152 0.0500 0.00330 0.115 NA 0.100 NA 0.109 4.2e-09 NA 4.9e-08 NA 1.0e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 2.6 0.7 0.0 -0.8 -1.0 0.0 1.6
Bipolar Disorder or Schizophrenia 0.4 0.9 3.2 -0.4 0.0 0.6 -0.7 -1.1 1.8
Depressed Affect (Nagel 2018) 0.3 0.7 1.6 0.9 0.0 -0.3 1.1 0.3 -1.3
Depression (Nagel 2018) 0.4 0.5 1.6 1.3 0.0 -0.9 -0.2 0.4 -0.7
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.4 -0.1 0.0 -0.1 -0.6 0.4 0.5
Neuroticism (Nagel 2018) 0.1 0.2 0.8 -0.2 0.0 -0.3 0.9 -0.5 -0.4
Schizophrenia (2018) 0.5 1.0 1.9 -1.1 0.0 1.4 -0.1 -1.4 1.0
Schizophrenia vs Biploar Disorder 0.7 1.0 2.4 -1.5 0.0 1.2 0.7 -1.2 -0.3
Worry (Nagel 2018) 0.3 0.6 1.6 -0.8 0.0 -0.4 1.3 -0.9 -0.2
Alzheimer’s Disease (in mother) 0.9 1.0 2.8 0.6 0.0 1.0 1.7 0.1 -1.4
Alzheimer’s Disease (in father) 0.1 0.1 0.3 -0.5 0.0 0.3 -0.4 0.2 -0.0
Alzheimer’s Disease (including proxy) 0.8 1.1 3.6 0.6 0.0 1.9 1.4 0.2 -0.7
Crohns Disease (2017) 0.5 1.1 4.3 2.1 0.0 -0.1 0.6 0.5 -1.3
Irritable Bowel Disease (IBD) 0.3 0.7 2.2 1.3 0.0 -0.4 0.6 -0.3 -1.5
Ulcerative Colitis (UC) 0.2 0.4 1.1 0.1 0.0 -0.3 0.4 -1.1 -0.9
Major Depression (MDD) 0.5 0.6 1.4 1.1 0.0 1.0 1.2 -0.4 -0.0
Reaction Time 0.5 0.9 2.3 1.2 0.0 -0.8 0.3 -1.5 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.4 -0.0 0.0 -1.1 -1.0 1.2 1.2
Breast Cancer 0.7 1.6 3.0 1.7 0.0 -1.3 1.5 0.9 1.4
Ovarian Cancer 0.7 0.9 4.0 2.0 0.0 0.4 0.9 -0.6 -0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 0.9 -0.6 0.0 -0.3 -0.8 1.0 -0.6
Bipolar Disorder (2011) 1.2 1.1 4.2 -1.1 0.0 -0.6 -1.0 -0.1 2.0
Body Mass Index (BMI) (2010) 0.6 0.8 3.2 0.4 0.0 -0.0 0.8 1.8 -1.0
Coronary Artery Disease (CAD) 0.5 0.6 2.3 -0.0 0.0 -1.5 0.3 -0.7 -0.9
Crohns Disease (2012) 0.4 0.7 1.4 0.1 0.0 -1.0 -1.1 1.2 -0.8
Mean Putamen Volume 0.5 0.5 1.5 -1.2 0.0 0.3 -0.3 -1.2 -0.2
Fasting Glucose 0.4 0.4 1.3 -0.4 0.0 0.4 -0.4 1.1 0.9
HbA1C 0.2 0.3 1.2 -0.0 0.0 -0.4 -0.2 0.3 1.1
HDL Cholesterol 0.3 0.5 2.1 0.1 0.0 0.8 0.4 -1.5 0.3
LDL Cholesterol 0.3 0.5 1.0 0.1 0.0 1.0 0.9 0.8 0.6
Lupus 0.6 0.9 3.5 0.1 0.0 1.0 0.3 -0.9 1.9
Neuroticism (2016) 0.7 1.0 2.4 0.2 0.0 1.4 1.1 0.5 -1.5
Primary Biliary Cirrhosis 0.2 0.3 0.7 -0.9 0.0 -0.6 0.2 0.0 -0.6
Rheumatoid Arthritis 0.8 1.2 3.5 0.1 0.0 -1.9 -1.2 -1.2 -0.7
Schizophrenia (2014) 0.3 0.6 1.3 -1.1 0.0 0.6 -0.5 -0.7 1.0
Triglycerides 1.7 2.8 7.7 1.6 0.0 1.4 2.0 2.8 -0.9
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 0.8 0.0 -0.3 -0.2 0.7 0.9
Ulcerative Colitis 0.3 0.5 2.7 -0.3 0.0 -0.5 0.0 0.0 -1.6
Blood Eosinophil Count 0.0 0.1 0.3 -0.6 0.0 -0.2 0.1 0.0 0.4
Blood Platelet Count 0.1 0.8 3.0 -0.3 0.0 -1.3 -0.2 -0.4 -1.7
Blood Red Count 0.2 2.4 9.9 -1.1 0.0 -3.1 -1.7 0.4 0.1
Blood White Count 0.2 1.6 6.4 -1.4 0.0 -1.0 -2.5 0.8 -0.1
Heel T-Score 0.7 5.5 10.7 1.7 0.0 3.3 3.2 2.5 -1.8
BMI 0.2 1.1 4.1 1.1 0.0 -0.7 0.5 0.9 -2.0
Height 2.6 49.4 243.4 2.4 0.0 0.1 -6.3 2.6 15.6
Waist Hip Ratio (WHR) 1.1 5.0 9.5 -3.0 0.0 -1.9 -2.4 -1.3 3.1
Systolic Blood Pressure 0.7 3.5 7.6 -2.5 0.0 -2.1 -2.8 -0.3 1.7
Smoking Status 0.1 0.3 1.5 -0.5 0.0 -0.3 -1.2 -0.4 -0.1
Allergy or Eczema 0.4 1.1 3.8 1.1 0.0 -1.2 -0.3 -0.3 2.0
Cardiovascular Disease 0.4 1.3 3.5 -1.9 0.0 -0.7 -1.9 -0.5 -0.1
Hypothyroidism (self reported) 0.2 0.4 1.2 -0.7 0.0 -1.1 -0.8 -0.5 -0.3
Respiratory disease 0.2 0.5 2.2 0.2 0.0 -1.5 -0.5 0.6 0.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 3.4 -1.1 0.0 -0.4 -0.6 1.9 -0.2
Lung FEV1/FVC ratio 1.0 5.0 12.3 2.2 0.0 1.9 3.5 2.8 -1.4
Lung FVC 0.7 3.4 11.6 0.9 0.0 -2.5 -0.2 1.3 -3.4
Neuroticism 0.3 0.6 2.1 -1.0 0.0 0.4 1.4 0.0 -0.6
Chronotype (morning person) 0.4 0.9 1.5 0.8 0.0 0.9 1.2 1.1 -1.2
Hair Pigment 0.0 0.6 2.4 -0.1 0.0 -1.5 0.0 -1.1 0.5
Tanning 0.0 0.3 0.5 -0.5 0.0 -0.5 -0.7 -0.6 0.7
Hand grip strength (left) 0.7 1.9 7.8 2.8 0.0 0.2 1.7 0.1 1.0
Number of treatments/medications taken 0.4 0.7 2.1 0.2 0.0 1.3 -0.0 1.5 0.7
Average weekly spirits intake 0.5 0.6 2.4 1.5 0.0 -0.4 0.8 0.0 -0.6
Sensitivity / hurt feelings 1.3 2.2 6.9 1.4 0.0 1.1 1.6 2.6 -0.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.4 1.2 0.0 -0.8 -0.1 -0.2 -0.2
Hearing difficulty/problems: Yes 0.4 0.6 1.7 0.8 0.0 0.7 0.3 1.3 0.9
Relative age of first facial hair 0.4 0.9 3.0 0.1 0.0 -0.8 0.5 -1.7 -1.3
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 4.5 0.2 0.0 0.6 -0.6 0.6 2.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.5 -0.2 0.0 1.0 0.3 0.2 1.2
Ever had hysterectomy (womb removed) 0.7 0.8 2.3 -1.1 0.0 -0.9 0.5 -0.7 -1.5
Systolic blood pressure, automated reading 0.5 1.4 3.5 -1.1 0.0 -1.5 -1.2 0.6 1.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.2 -1.1 0.0 -0.2 0.9 -1.0 0.8
Angina 0.8 1.0 5.7 0.2 0.0 -0.3 -0.5 -2.4 -0.2
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.8 0.0 0.4 -0.8 0.1 0.7
Vitamin and mineral supplements 0.4 0.5 2.0 -0.1 0.0 0.3 1.4 -0.6 0.9
Supplements: Zinc 0.3 0.3 1.7 0.2 0.0 1.3 0.1 0.3 -0.0
Medication: Co-codamol 0.8 0.9 4.0 -2.0 0.0 -0.7 -0.8 -0.2 -0.1
Medication: Metformin 0.2 0.3 1.7 -0.2 0.0 0.1 -0.0 1.3 -0.0
Diabetes (father) 0.3 0.4 1.0 1.0 0.0 0.5 0.9 -0.5 -0.4
Diabetes (mother) 0.0 0.0 0.1 -0.1 0.0 -0.2 0.2 0.3 0.0
Severe depression (siblings) 1.0 1.1 3.3 1.8 0.0 0.4 1.6 -0.5 -0.8
Pack years adult smoking proportion 0.7 1.1 5.6 -0.7 0.0 0.4 0.0 0.1 -2.4
Impedance of leg (right) 0.2 1.2 3.0 0.9 0.0 1.7 1.7 -0.2 0.7
Leg fat-free mass (left) 1.2 6.5 22.1 0.1 0.0 -1.2 -3.4 1.9 4.7
Trunk fat percentage 0.2 0.8 2.7 -0.3 0.0 -0.2 -0.3 1.6 1.4
Hand grip strength (right) 0.9 2.4 10.7 3.3 0.0 0.4 1.6 0.6 0.6
Townsend deprivation index at recruitment 0.4 0.6 1.9 -1.2 0.0 -0.2 -1.4 -0.0 0.2
Current tobacco smoking 0.2 0.2 1.2 1.1 0.0 -0.3 -0.2 0.3 -0.3
Average weekly fortified wine intake 0.7 0.8 2.5 -0.7 0.0 -0.9 -0.7 1.6 0.7
Maternal smoking around birth 0.6 0.8 2.0 1.4 0.0 -0.7 0.5 1.1 -0.9
Fed-up feelings 0.3 0.6 2.4 1.6 0.0 -0.5 0.6 -0.2 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.4 1.6 0.0 -0.3 -0.0 0.1 -1.5
Relative age voice broke 0.3 0.5 1.3 -0.7 0.0 -1.1 -0.1 -1.1 0.1
Taking other prescription medications 0.4 0.7 1.6 0.8 0.0 -0.3 -1.1 0.8 1.3
Age when periods started (menarche) 0.7 1.6 5.3 -0.5 0.0 2.3 1.7 0.5 1.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.5 -1.2 0.0 0.4 -0.1 0.0 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 4.8 0.7 0.0 2.0 2.2 1.1 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 -0.7 0.0 0.5 0.4 -1.0 0.1
Qualifications: CSEs or equivalent 1.3 1.7 4.2 1.7 0.0 1.1 0.8 -1.2 -2.0
Serious illness, injury or assault to yourself 0.2 0.2 0.7 0.8 0.0 -0.1 0.3 -0.5 0.6
High blood pressure 0.1 0.2 0.6 -0.8 0.0 0.3 -0.2 -0.4 0.1
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.8 1.1 0.0 -0.5 0.3 -0.3 1.7
Multivitamins +/- minerals 1.6 2.1 5.1 0.7 0.0 -1.6 -1.8 1.0 -2.3
Stomach or abdominal pain in last month 1.3 1.7 3.2 1.8 0.0 1.6 1.6 0.1 -1.3
Supplements: Glucosamine 0.1 0.1 0.3 0.1 0.0 0.2 -0.1 -0.2 0.6
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 8.8 3.0 0.0 -0.3 0.6 0.8 1.0
Medication: Atenolol 0.1 0.2 0.8 0.3 0.0 0.2 0.2 -0.9 -0.1
Medication: Levothyroxine sodium 0.2 0.4 1.9 -0.5 0.0 -0.4 0.0 -0.1 -1.4
Sitting height 2.6 18.3 55.7 0.3 0.0 -1.7 -6.2 3.5 7.5
Chronic bronchitis/emphysema (father) 0.8 0.9 3.0 1.4 0.0 -0.0 0.8 -1.7 0.2
High blood pressure (mother) 0.3 0.4 1.0 -0.6 0.0 -0.8 -0.0 1.0 -0.8
Body mass index (BMI) 0.2 0.9 3.2 0.5 0.0 0.3 0.9 1.1 -1.8
Impedance of leg (left) 0.2 1.0 2.9 0.7 0.0 1.5 1.7 -0.2 0.7
Leg predicted mass (left) 1.2 6.3 21.8 0.2 0.0 -1.2 -3.3 1.9 4.7
Trunk fat mass 0.5 2.0 7.2 0.3 0.0 -0.1 -0.7 2.0 2.7
Waist circumference 0.4 1.3 4.1 -0.9 0.0 -0.5 -1.4 0.9 2.0
Number of incorrect matches in round 0.3 0.5 1.4 1.0 0.0 -0.0 -1.2 0.7 -0.2
Past tobacco smoking 0.1 0.1 0.4 0.4 0.0 -0.6 0.1 -0.4 -0.2
Alcohol usually taken with meals 0.1 0.2 0.5 -0.2 0.0 0.7 0.4 0.7 -0.2
Nervous feelings 0.9 1.7 2.9 -1.5 0.0 -1.6 -1.2 -1.7 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.4 1.2 0.0 -0.1 -0.2 -0.9 -0.6
Hearing difficulty/problems with background noise 0.6 1.0 4.9 2.2 0.0 0.4 0.9 0.6 -0.0
Hair/balding pattern: Pattern 2 1.0 1.3 2.8 -0.9 0.0 -1.7 -1.1 -1.2 1.2
Had menopause 0.7 0.8 2.3 -1.5 0.0 0.7 -0.4 0.9 1.1
Had other major operations 0.7 0.8 2.9 -0.1 0.0 1.7 1.3 -0.4 -0.0
Forced vital capacity (FVC) 0.9 3.3 8.5 1.3 0.0 -1.8 -2.4 0.9 2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.8 1.4 0.0 1.3 1.9 0.3 -0.3
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.5 1.6 0.0 -1.2 0.8 -1.0 -0.4
Qualifications: None of the above 0.4 0.9 2.3 -0.4 0.0 -1.5 -1.0 1.5 -0.0
Financial difficulties in last 2 years 1.0 1.4 3.8 0.1 0.0 -0.4 -1.8 -1.0 2.0
Mouth/teeth dental problems 0.8 1.2 3.8 -2.0 0.0 -1.1 -1.4 -0.2 -0.0
Heart attack 0.2 0.3 0.7 0.9 0.0 0.5 0.1 -0.7 -0.4
Allergy 0.2 0.4 1.1 -1.0 0.0 0.0 -0.7 -0.2 -0.8
Pain all over the body in last month 1.1 1.2 4.3 -0.3 0.0 -0.8 -1.1 -1.1 2.1
Diabetes (self-reported) 0.5 0.8 2.0 -1.3 0.0 1.0 0.3 1.4 0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.9 0.2 0.0 -0.5 -0.2 0.2 -1.0
Medication: Ramipril 0.9 1.2 3.4 -1.9 0.0 -0.6 -1.7 -0.2 0.7
Medication: Simvastatin 0.3 0.4 0.8 -0.8 0.0 0.9 0.1 0.7 0.7
Fluid intelligence score 0.2 0.3 1.5 -0.2 0.0 -0.3 -0.5 0.5 1.2
Illnesses of siblings 1.1 1.5 4.5 -0.9 0.0 -1.5 -1.0 -0.6 2.1
Neuroticism score 0.3 0.6 2.2 0.3 0.0 0.0 1.5 -0.1 -1.1
Weight 0.7 3.5 12.7 0.8 0.0 -0.2 -1.7 2.3 3.6
Impedance of arm (right) 0.5 2.2 5.9 -1.3 0.0 -1.8 -1.4 -0.6 2.4
Arm fat percentage (right) 0.0 0.2 0.3 -0.3 0.0 -0.3 0.4 0.5 -0.5
Trunk fat-free mass 1.1 6.3 26.3 1.1 0.0 -0.3 -2.6 1.9 5.1
Hip circumference 0.4 1.8 6.8 0.7 0.0 0.1 -0.7 1.7 2.6
Time employed in main current job 0.3 0.4 0.8 -0.9 0.0 -0.5 -0.7 0.8 0.4
Alcohol intake versus 10 years previously 0.5 0.7 1.7 0.6 0.0 -1.3 -1.3 0.3 -0.3
Father’s age at death 1.3 1.7 6.1 -1.1 0.0 -0.5 -1.7 0.3 2.5
Worrier / anxious feelings 0.3 0.5 1.3 1.1 0.0 0.6 0.6 -0.8 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 5.3 2.3 0.0 0.3 0.2 0.6 -0.1
Falls in the last year 0.2 0.3 1.4 -1.2 0.0 -0.3 -0.5 -0.2 0.3
Hair/balding pattern: Pattern 3 0.3 0.4 1.2 0.5 0.0 0.5 0.8 -1.1 0.6
Number of live births 0.1 0.1 0.2 0.4 0.0 -0.4 0.4 -0.2 0.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 2.8 1.4 0.0 -1.0 -1.1 1.7 1.5
Pulse rate 0.8 1.4 3.2 -1.8 0.0 -1.5 -1.2 0.6 0.9
Happiness 1.0 1.2 4.6 -0.0 0.0 -2.1 -1.2 -0.8 -0.8
Noisy workplace 0.4 0.5 1.5 1.2 0.0 -0.3 0.9 -0.3 0.6
Qualifications: A levels/AS levels or equivalent 1.1 2.5 7.3 -2.7 0.0 0.3 -1.1 -2.5 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.9 1.0 0.0 -0.8 -0.1 -0.2 -0.1
Mouth/teeth dental problems: Dentures 0.6 1.1 3.8 1.9 0.0 0.6 1.4 -0.1 -0.1
Asthma 0.1 0.1 0.4 -0.3 0.0 0.3 0.3 -0.1 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.5 1.6 0.0 1.2 0.7 1.6 -0.9
Medication: Cholesterol lowering 0.6 0.9 3.5 0.3 0.0 1.2 -0.4 0.4 1.9
Depression (self-reported) 0.3 0.3 0.9 0.4 0.0 -0.6 0.8 -0.9 -0.1
Medication: Lansoprazole 0.1 0.1 0.4 -0.2 0.0 -0.2 -0.0 -0.6 0.1
Prospective memory result 0.8 0.9 2.7 -0.6 0.0 1.6 0.2 1.5 -0.6
Lung cancer (father) 0.5 0.6 1.5 -1.2 0.0 0.3 -0.4 0.8 -1.2
Illnesses of mother 0.4 0.4 1.8 -0.1 0.0 -0.3 -0.9 -1.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 2.1 1.3 0.0 -1.2 -1.1 1.5 1.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 0.0 0.0 -1.0 -0.7 0.6 1.1
Impedance of arm (left) 0.5 2.2 5.3 -1.6 0.0 -1.7 -1.4 -0.8 2.3
Arm fat mass (right) 0.1 0.4 1.3 0.3 0.0 -0.1 -0.2 1.1 1.0
Trunk predicted mass 1.1 6.3 27.0 1.1 0.0 -0.2 -2.5 1.8 5.2
Standing height 3.0 30.1 139.2 0.7 0.0 -1.0 -5.7 2.6 11.8
Length of working week for main job 0.8 0.9 2.5 0.9 0.0 1.2 0.3 1.6 0.8
Exposure to tobacco smoke at home 0.6 0.7 1.6 0.2 0.0 1.0 1.3 -1.1 0.5
Breastfed as a baby 1.7 2.1 5.7 -0.4 0.0 2.3 1.3 2.4 0.2
Tense / ‘highly strung’ 0.5 0.9 3.5 -0.2 0.0 0.4 0.9 -0.9 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.2 6.9 1.0 0.0 1.9 2.6 -0.6 -1.1
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 0.4 0.0 0.0 0.4 0.3 -0.3
Birth weight of first child 1.6 2.8 7.1 0.3 0.0 1.9 -0.3 2.5 2.7
Peak expiratory flow (PEF) 0.3 0.7 2.2 1.5 0.0 0.1 -0.1 1.3 0.7
Pulse wave reflection index 0.5 0.6 2.3 0.6 0.0 -0.3 1.0 -0.3 -1.5
Ever highly irritable/argumentative for 2 days 2.5 3.0 14.5 0.6 0.0 -1.8 0.6 -3.8 -0.0
Loud music exposure frequency 0.4 0.4 1.7 0.6 0.0 -1.3 -0.5 -0.5 -0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 0.0 0.0 -0.5 -0.6 -0.9 0.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.6 0.0 0.0 1.2 0.5 0.1 -0.1
Blood clot in the leg (DVT) 0.9 1.1 2.9 0.8 0.0 1.7 1.1 1.1 -0.7
Medication: Paracetamol 0.8 1.3 5.4 2.3 0.0 0.7 0.8 0.9 0.2
Headache pain in last month 1.0 1.7 4.2 1.3 0.0 1.3 1.4 2.1 -0.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 2.5 0.5 0.0 -1.6 -0.2 -0.3 -0.7
Glaucoma (self-reported) 0.1 0.1 0.2 -0.1 0.0 -0.5 -0.4 -0.4 -0.2
Gout (self-reported) 0.4 0.5 2.1 1.5 0.0 0.4 0.4 0.9 0.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.6 -0.5 0.0 -1.3 -0.5 -1.2 -0.7
Medication: Amlodipine 0.1 0.1 0.3 -0.5 0.0 0.3 -0.1 -0.0 -0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 0.5 0.0 -0.8 -0.3 0.2 -0.3
Birth weight 1.5 3.3 9.1 1.4 0.0 -0.9 -0.2 2.9 3.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.8 2.0 0.0 0.2 1.0 -0.2 -0.1
High blood pressure (siblings) 0.9 1.3 4.2 0.4 0.0 1.3 1.0 1.0 -2.1
Forced vital capacity (FVC), Best measure 1.0 3.6 8.1 1.0 0.0 -2.3 -2.6 0.2 2.9
Body fat percentage 0.1 0.3 1.5 -0.1 0.0 0.2 0.4 1.2 0.5
Leg fat percentage (right) 0.4 1.5 3.6 0.9 0.0 1.2 1.9 1.2 -1.3
Arm fat-free mass (right) 1.0 5.3 21.3 1.3 0.0 0.4 -1.9 2.2 4.6
Exposure to tobacco smoke outside home 1.4 1.9 9.4 3.1 0.0 -1.2 0.6 -0.0 -0.2
Comparative body size at age 10 0.5 1.4 2.6 1.6 0.0 -0.1 1.5 1.3 -1.4
Number of full brothers 0.5 0.6 1.8 -0.5 0.0 -0.3 0.3 1.3 1.2
Worry too long after embarrassment 0.2 0.3 1.1 0.1 0.0 -0.3 0.6 0.1 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 8.1 0.6 0.0 2.1 2.8 0.1 -0.6
Wheeze or whistling in the chest in last year 0.5 1.0 3.9 0.4 0.0 2.0 0.9 -0.2 0.9
Number of children fathered 0.5 0.6 1.0 -0.9 0.0 1.0 0.9 -0.9 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.0 0.2 0.0 -1.0 -0.9 -0.7 -0.2
Age at first live birth 1.2 2.1 6.0 -1.6 0.0 -1.5 -2.5 -0.5 1.2
Pulse wave peak to peak time 0.2 0.3 0.9 0.2 0.0 0.9 0.5 -0.6 -0.4
Health satisfaction 2.0 2.6 5.7 -2.4 0.0 -2.4 -1.6 -1.2 0.4
Shortness of breath walking on level ground 3.8 4.5 13.3 -1.2 0.0 -3.6 -3.2 -1.4 -0.4
Qualifications: College or University degree 0.4 1.2 2.9 -1.7 0.0 1.0 0.5 0.5 1.6
Eye problems/disorders: None of the above 0.4 0.4 1.3 1.0 0.0 -0.1 -0.0 -1.1 -0.5
Mouth/teeth dental problems: Loose teeth 0.9 1.0 2.2 1.5 0.0 0.8 1.3 1.1 0.6
Emphysema/chronic bronchitis 0.4 0.5 2.5 0.7 0.0 0.1 0.3 1.6 0.1
Medication for pain relief, constipation, heartburn 0.5 0.8 3.2 -1.8 0.0 -0.5 -0.3 -1.1 -0.0
Neck or shoulder pain in last month 0.5 0.8 2.4 -0.3 0.0 1.6 0.6 1.2 -0.6
Medication: Blood pressure 0.5 0.9 3.9 -0.9 0.0 2.0 0.6 0.4 0.3
Angina (self-reported) 0.8 1.1 6.1 0.2 0.0 -0.3 -0.4 -2.5 -0.2
Migraine (self-reported) 0.5 0.6 1.6 0.3 0.0 0.4 1.1 0.5 -1.3
Medication: Ibuprofen 0.4 0.5 1.1 0.5 0.0 1.0 0.5 0.9 -0.6
Medication: Allopurinol 0.4 0.5 2.5 1.6 0.0 0.3 0.4 0.4 0.6
Medication: Omeprazole 0.9 1.1 2.9 0.7 0.0 -0.8 -1.7 -0.2 1.6
Medication: Seretide 50 evohaler 1.9 2.2 11.2 -0.7 0.0 0.7 -0.8 -0.3 3.3
Mean time to correctly identify matches 0.2 0.3 1.1 1.0 0.0 0.2 0.8 0.1 -0.3
Heart disease (mother) 1.1 1.3 4.7 -1.3 0.0 -0.9 -2.2 0.2 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.8 -0.2 0.0 0.1 -1.7 0.2 0.3
Whole body fat mass 0.3 1.3 3.8 0.2 0.0 0.2 -0.3 1.9 1.9
Leg fat mass (right) 0.2 0.9 2.7 0.9 0.0 1.0 0.4 1.6 0.7
Arm predicted mass (right) 1.0 5.2 20.4 1.3 0.0 0.3 -2.0 2.3 4.5
Pulse rate, automated reading 0.1 0.2 0.8 -0.3 0.0 -0.9 -0.1 0.4 -0.1
Alcohol intake frequency. 0.2 0.5 1.2 0.4 0.0 -0.6 0.2 -1.1 -1.1
Comparative height size at age 10 3.8 21.1 99.6 2.4 0.0 -0.5 -4.0 2.2 10.0
Number of full sisters 0.4 0.5 1.7 -0.0 0.0 1.3 1.0 -0.5 -0.4
Suffer from ‘nerves’ 0.6 0.9 2.2 -1.1 0.0 -1.2 0.4 -1.5 -0.4
Overall health rating 0.4 0.8 2.0 -0.9 0.0 0.1 -1.1 -0.7 1.4
Chest pain or discomfort 0.1 0.2 0.7 0.5 0.0 -0.1 -0.1 0.1 -0.8
Had major operations 0.7 0.9 2.5 0.1 0.0 1.2 0.8 1.6 0.7
Age at last live birth 0.4 0.6 2.1 -0.2 0.0 -0.7 -0.8 -0.5 1.4
Family relationship satisfaction 1.3 1.6 6.0 0.4 0.0 -0.8 0.1 -2.4 -1.6
Leg pain on walking 0.5 0.7 1.2 -0.3 0.0 -1.1 -0.9 0.9 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.5 1.9 0.0 -1.0 -0.0 -1.0 -1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.9 0.7 0.0 -0.6 -0.7 0.3 -1.0
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.3 -1.5 0.0 0.3 0.0 1.5 -0.9
Medication: Aspirin 0.1 0.1 0.4 0.6 0.0 0.1 0.2 -0.2 -0.2
Supplements: Vitamin C 0.8 0.9 3.1 -1.2 0.0 0.0 -1.8 -0.6 0.7
Knee pain experienced in last month 0.1 0.2 0.7 0.8 0.0 -0.1 -0.4 0.2 0.6
Hypertension (Self-reported) 0.1 0.2 0.7 -0.5 0.0 0.8 0.4 -0.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.9 1.4 0.0 -0.9 0.6 -1.4 -0.1
Illnesses of father: Heart disease 0.4 0.6 1.2 -1.1 0.0 -0.3 -1.1 1.0 -0.2
Illnesses of siblings: Diabetes 0.6 0.8 1.8 0.2 0.0 1.3 1.1 0.3 -1.2
Smoking status: Previous 0.5 0.8 2.6 -1.6 0.0 0.7 -0.9 0.4 0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.9 3.9 12.9 1.4 0.0 -0.9 -1.6 2.3 3.6
Whole body fat-free mass 1.1 6.4 24.4 0.8 0.0 -0.6 -2.9 2.0 4.9
Leg fat-free mass (right) 1.3 6.7 20.9 -0.0 0.0 -1.5 -3.6 2.0 4.6
Arm fat percentage (left) 0.1 0.2 0.3 -0.5 0.0 -0.4 0.5 0.5 -0.6
Average weekly red wine intake 0.5 0.7 3.0 -1.7 0.0 0.0 -0.6 -0.7 0.4
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.5 -0.5 0.0 -0.1 -0.2 -0.7 0.0
Mood swings 0.4 0.7 1.8 0.3 0.0 -1.3 0.9 -0.6 -1.1
Loneliness, isolation 0.4 0.6 1.8 1.0 0.0 -0.2 0.8 0.5 -1.3
Long-standing illness, disability or infirmity 1.6 2.4 8.1 -1.5 0.0 -0.2 -2.8 -0.1 2.0
Ever had bowel cancer screening 0.6 0.7 2.7 0.5 0.0 1.0 0.5 1.6 -0.1
Diabetes diagnosed by doctor 0.4 0.6 2.1 -1.5 0.0 0.5 -0.5 0.7 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.9 -0.2 0.0 0.3 0.3 -0.2 -1.0
Friendships satisfaction 0.6 0.7 2.6 -0.0 0.0 -0.6 1.1 -0.2 -1.6
Qualifications: nursing, teaching 0.2 0.3 0.8 -0.2 0.0 0.9 0.8 -0.8 -0.0
Commuting to job workplace: Walk 1.2 1.3 6.3 -0.6 0.0 0.8 -0.3 -2.5 0.4
Eye problems/disorders: Cataract 0.4 0.5 1.8 -1.3 0.0 0.2 -0.7 0.3 0.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.3 0.6 0.0 1.5 1.8 0.8 -0.5
Medication for cholesterol 0.2 0.3 1.4 0.1 0.0 -0.2 -0.2 1.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.2 0.8 0.0 0.7 0.8 -0.4 -1.1
Back pain experienced in last month 0.3 0.5 1.7 -0.6 0.0 1.3 -0.0 -0.2 0.8
Mineral and other dietary supplements 0.2 0.2 0.5 -0.7 0.0 -0.6 0.2 0.1 -0.6
Breast cancer (self-reported) 0.6 0.7 1.7 0.9 0.0 0.8 1.0 1.3 -0.3
Asthma (self-reported) 0.1 0.1 0.7 -0.4 0.0 0.1 0.1 -0.1 0.8
Osteoporosis (self-reported) 1.8 2.2 11.2 -3.4 0.0 0.2 -0.9 -0.3 1.1
Osteoarthritis (self-reported) 0.4 0.5 1.0 0.0 0.0 1.0 -1.0 -0.9 0.5
Medication: Aspirin 0.1 0.1 0.4 -0.1 0.0 -0.2 -0.3 -0.7 -0.1
Medication: Gliclazide 0.6 0.7 1.9 -1.0 0.0 -1.4 -0.6 0.3 0.9
Illnesses of father: None of the above (group 1) 0.2 0.2 1.0 0.0 0.0 0.2 0.6 0.3 1.0
Smoking status: Current 0.2 0.3 1.8 1.3 0.0 -0.3 0.1 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.1 0.8 0.0 -1.1 -0.2 -0.4 -0.3
Whole body water mass 1.2 6.6 25.8 0.7 0.0 -0.6 -3.0 2.0 5.1
Leg predicted mass (right) 1.3 6.7 21.3 0.0 0.0 -1.5 -3.6 2.0 4.6
Arm fat mass (left) 0.1 0.4 1.3 0.0 0.0 -0.1 -0.4 1.1 1.1
Number of self-reported non-cancer illnesses 0.5 0.9 2.7 -0.6 0.0 1.6 -0.3 0.4 1.4
Average weekly champagne plus white wine intake 0.6 0.9 3.2 -1.8 0.0 -0.2 -0.5 1.3 -0.0
Miserableness 0.9 1.5 4.8 1.5 0.0 -1.1 0.8 0.1 -2.2
Guilty feelings 0.6 0.9 3.4 0.5 0.0 0.8 1.2 0.0 1.8
Wears glasses or contact lenses 1.3 1.5 4.1 -0.4 0.0 2.0 1.5 1.4 -0.8
Ever taken oral contraceptive pill 0.2 0.3 1.4 0.3 0.0 -0.2 0.1 -1.2 0.2
Hearing aid user 0.4 0.4 0.9 -0.7 0.0 -1.0 -0.9 -0.1 0.5
Mother’s age at death 0.8 0.9 3.6 -0.3 0.0 0.9 -0.9 0.6 1.9
Financial situation satisfaction 1.9 2.3 4.9 -1.0 0.0 -1.7 -1.6 -2.2 1.6
Tinnitus: Yes, now most or all of the time 0.8 1.0 3.1 1.8 0.0 -1.4 0.4 -0.1 -0.8
Commuting to job workplace: Public transport 0.6 0.7 4.0 -2.0 0.0 0.0 0.0 0.2 -0.4
Eye problems/disorders: Glaucoma 0.6 0.7 1.9 -0.8 0.0 -1.2 -1.4 0.5 0.0
Medication: Blood pressure 0.1 0.1 0.3 0.5 0.0 -0.2 0.4 -0.3 -0.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 2.3 -1.0 0.0 1.5 0.3 1.1 0.6
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.6 0.0 0.7 -0.2 0.1 0.6
High cholesterol (Self-reported) 0.2 0.4 1.3 -0.6 0.0 1.2 -0.5 0.3 0.5
Medication: Bendroflumethiazide 1.0 1.5 4.6 0.3 0.0 2.1 1.8 -0.1 -1.0
Medication: Paracetamol 0.3 0.5 1.8 1.3 0.0 -0.0 0.0 0.9 0.4
Medication: Lisinopril 0.3 0.4 1.4 -0.0 0.0 -0.3 -0.9 -0.2 -1.2
Medication: Atorvastatin 0.2 0.3 1.1 0.4 0.0 0.4 -1.0 0.2 0.3
Illnesses of father: High blood pressure 1.1 1.4 5.5 1.1 0.0 -0.7 0.4 -0.9 -2.3
Alcohol drinker status: Never 0.4 0.4 1.3 -0.7 0.0 -0.2 -0.5 0.8 -1.1
Ever smoked 0.1 0.2 0.6 0.5 0.0 0.7 0.8 0.1 -0.2
Basal metabolic rate 1.1 6.0 23.1 0.7 0.0 -0.6 -2.8 2.1 4.8
Leg fat percentage (left) 0.4 1.4 3.3 0.7 0.0 1.1 1.8 1.2 -1.3
Arm fat-free mass (left) 1.0 5.0 18.7 1.3 0.0 0.4 -1.8 2.5 4.3
Number of operations (self-reported) 0.4 0.7 2.8 0.3 0.0 1.7 0.6 0.2 0.8
Average weekly beer plus cider intake 0.5 0.7 2.2 0.9 0.0 -1.0 0.2 0.6 -1.5
Irritability 0.2 0.3 0.8 -0.1 0.0 0.5 -0.0 -0.9 -0.7
Risk taking 0.4 0.6 2.4 0.1 0.0 0.5 0.3 1.6 -0.9
Ever had prostate specific antigen (PSA) test 0.9 1.0 3.7 0.8 0.0 1.9 0.7 0.8 -0.7
Fractured/broken bones in last 5 years 1.4 1.8 5.8 -2.4 0.0 -1.1 -1.4 -0.8 1.1
Age started oral contraceptive pill 0.4 0.6 1.4 1.0 0.0 -0.2 1.0 1.2 0.1
Diastolic blood pressure, automated reading 0.1 0.4 2.4 0.3 0.0 -0.0 0.2 1.6 -0.2
Ever depressed for a whole week 0.2 0.3 1.1 0.2 0.0 -1.0 0.3 -0.4 -0.6
Unable to work because of sickness or disability 0.8 1.0 2.2 -0.0 0.0 -0.4 -1.3 1.4 1.5
Commuting to job workplace: Cycle 0.3 0.4 1.0 -0.5 0.0 -1.0 -0.6 -0.8 -0.3
Myopia 0.2 0.3 1.0 -0.4 0.0 -0.5 -0.8 -0.3 -1.0
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.3 0.4 0.0 -0.1 0.1 0.5 -0.4
Cholesterol lowering medication 0.3 0.5 1.7 -1.3 0.0 0.5 0.1 -0.8 -0.3
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.4 0.6 0.0 -1.7 -1.8 -0.6 1.1
Pain experienced in last month 0.5 0.9 2.2 -0.2 0.0 -1.4 -0.7 -1.5 -0.9
Supplements: Calcium 0.6 0.7 2.9 -0.8 0.0 -0.3 -1.7 -0.4 0.7
Basal cell carcinoma (self-reported) 0.6 0.7 2.1 1.5 0.0 1.4 0.4 0.1 -0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.8 0.9 0.0 0.3 -0.1 -0.9 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.4 1.0 0.0 1.6 1.2 1.0 -0.8
Heart disease (siblings) 0.5 0.7 3.1 -0.7 0.0 0.5 -0.4 -1.8 0.1
Alcohol drinker status: Previous 0.6 0.7 2.8 0.4 0.0 -0.1 1.7 0.2 -1.1
Pack years of smoking 0.8 1.2 5.3 -0.8 0.0 1.0 0.4 0.5 -2.3
Impedance of whole body 0.1 0.7 3.6 -0.5 0.0 -0.4 -0.2 -0.3 1.9
Leg fat mass (left) 0.2 0.7 2.4 0.7 0.0 0.9 0.4 1.5 0.8
Arm predicted mass (left) 0.9 4.7 17.2 1.2 0.0 0.7 -1.6 2.5 4.2