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chr7:133,730,639-136,094,817

Best TWAS P=6.23e-39 · Best GWAS P=1.25e-36 conditioned to 2.17e-15

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C7orf73	0.19	0.19	lasso	8	0.22	1.3e-26	11.782	-9.3	9.1e-21	0.22	0.97	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM140	0.03	0.00	blup	467	0.02	5.0e-03	0.318	7.3	3.1e-13	-0.05	0.14	0.02	FALSE
3	GTEx	Adipose Subcutaneous	C7orf73	0.23	0.14	lasso	7	0.18	9.5e-15	10.743	-12.3	7.8e-35	0.30	0.99	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	C7orf73	0.18	0.11	lasso	4	0.09	2.8e-05	10.743	-11.2	4.5e-29	0.36	0.93	0.03	FALSE
5	GTEx	Adrenal Gland	C7orf73	0.24	0.23	lasso	1	0.21	3.8e-08	11.935	-11.9	7.8e-33	0.31	0.70	0.13	FALSE
6	GTEx	Artery Aorta	C7orf73	0.27	0.23	lasso	4	0.21	1.5e-11	11.935	-12.3	5.4e-35	0.27	0.87	0.13	FALSE
7	GTEx	Artery Coronary	C7orf49	0.21	0.08	enet	28	0.16	3.9e-06	-0.012	-5.9	3.1e-09	0.02	0.31	0.04	FALSE
8	GTEx	Artery Coronary	C7orf73	0.40	0.29	enet	18	0.30	1.3e-10	10.743	-12.5	1.4e-35	0.35	0.99	0.01	FALSE
9	GTEx	Artery Tibial	C7orf73	0.18	0.18	lasso	5	0.18	2.5e-14	11.782	-12.4	2.1e-35	0.31	0.95	0.05	FALSE
10	GTEx	Brain Cerebellum	C7orf73	0.47	0.08	lasso	6	0.29	2.4e-09	0.702	-7.6	3.9e-14	0.11	0.47	0.06	FALSE
11	GTEx	Breast Mammary Tissue	C7orf73	0.15	0.11	lasso	6	0.15	4.3e-08	11.782	-13.0	7.8e-39	0.30	0.93	0.04	FALSE
12	GTEx	Breast Mammary Tissue (Male)	C7orf73	0.24	0.08	lasso	8	0.14	3.5e-04	-9.614	-9.8	1.5e-22	0.10	0.07	0.05	FALSE
13	GTEx	Breast Mammary Tissue (Female)	C7orf73	0.20	0.17	lasso	4	0.12	1.5e-04	11.935	-12.2	1.8e-34	0.33	0.29	0.07	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	CNOT4	0.19	0.03	enet	8	0.07	3.3e-03	-1.324	-8.0	1.0e-15	0.16	0.08	0.05	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	C7orf73	0.49	0.28	enet	33	0.44	7.4e-16	11.782	-11.2	3.1e-29	0.21	0.97	0.03	FALSE
16	GTEx	Cells Transformed fibroblasts	CALD1	0.15	0.03	enet	41	0.04	9.7e-04	-1.576	-6.6	3.5e-11	-0.02	0.12	0.04	FALSE
17	GTEx	Cells Transformed fibroblasts	C7orf73	0.44	0.49	lasso	8	0.53	5.3e-46	11.782	-12.4	2.4e-35	0.32	0.96	0.04	FALSE
18	GTEx	Colon Sigmoid	C7orf73	0.25	0.22	lasso	2	0.21	6.1e-08	11.935	-12.6	1.6e-36	0.27	0.57	0.10	FALSE
19	GTEx	Colon Sigmoid	RP11-134L10.1	0.17	-0.01	lasso	5	0.00	5.1e-01	9.603	-9.4	6.2e-21	0.09	0.06	0.06	TRUE
20	GTEx	Colon Transverse	C7orf73	0.25	0.29	lasso	5	0.24	1.1e-11	11.935	-11.8	3.8e-32	0.28	0.86	0.14	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	C7orf73	0.25	0.19	lasso	3	0.14	8.6e-06	11.782	-11.9	7.8e-33	0.29	0.52	0.07	FALSE
22	GTEx	Esophagus Mucosa	C7orf73	0.42	0.31	lasso	6	0.38	1.3e-26	11.935	-13.1	6.2e-39	0.30	0.87	0.13	TRUE
23	GTEx	Esophagus Muscularis	C7orf73	0.22	0.31	lasso	2	0.29	8.8e-18	11.935	-12.1	8.6e-34	0.31	0.86	0.14	FALSE
24	GTEx	Heart Atrial Appendage	C7orf73	0.14	0.12	enet	10	0.09	7.4e-05	10.082	-10.7	6.3e-27	0.31	0.63	0.09	FALSE
25	GTEx	Heart Left Ventricle	C7orf73	0.14	0.09	lasso	12	0.07	2.1e-04	11.558	-11.9	1.9e-32	0.38	0.88	0.03	FALSE
26	GTEx	Lung	C7orf73	0.26	0.21	lasso	10	0.22	1.5e-16	11.935	-12.6	1.7e-36	0.34	0.88	0.12	FALSE
27	GTEx	Muscle Skeletal	C7orf73	0.11	0.06	lasso	6	0.08	4.2e-08	9.724	-9.6	6.4e-22	0.34	1.00	0.00	FALSE
28	GTEx	Nerve Tibial	C7orf73	0.19	0.10	lasso	9	0.18	9.5e-13	11.782	-12.2	4.8e-34	0.24	0.96	0.04	FALSE
29	GTEx	Pancreas	C7orf73	0.22	0.28	lasso	8	0.28	4.5e-12	11.782	-12.2	5.3e-34	0.29	0.95	0.05	FALSE
30	GTEx	Prostate	C7orf73	0.50	0.21	enet	46	0.29	5.3e-08	11.782	-9.2	3.6e-20	0.19	0.46	0.06	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	C7orf73	0.38	0.33	lasso	5	0.37	2.3e-21	11.782	-12.7	4.0e-37	0.32	0.97	0.03	FALSE
32	GTEx	Skin Sun Exposed Lower leg	NUP205	0.07	0.03	lasso	4	0.04	6.2e-04	-7.734	9.4	6.0e-21	-0.09	0.18	0.03	FALSE
33	GTEx	Skin Sun Exposed Lower leg	C7orf73	0.29	0.28	enet	21	0.32	3.2e-27	11.782	-12.5	4.3e-36	0.31	0.96	0.04	FALSE
34	GTEx	Stomach	C7orf73	0.29	0.17	lasso	6	0.13	6.3e-07	11.935	-11.5	9.2e-31	0.29	0.87	0.13	FALSE
35	GTEx	Testis	C7orf73	0.38	0.27	lasso	4	0.30	1.1e-13	11.782	-11.5	1.2e-30	0.28	0.91	0.09	FALSE
36	GTEx	Thyroid	WDR91	0.11	0.00	enet	44	0.01	5.1e-02	-3.254	5.1	2.7e-07	-0.11	0.08	0.05	FALSE
37	GTEx	Thyroid	C7orf73	0.18	0.11	lasso	7	0.16	2.1e-12	10.743	-11.8	3.2e-32	0.40	1.00	0.00	FALSE
38	GTEx	Uterus	C7orf73	0.35	0.23	lasso	5	0.21	4.8e-05	10.743	-11.0	3.1e-28	0.38	0.07	0.14	FALSE
39	GTEx	Vagina	C7orf73	0.27	0.19	lasso	3	0.17	9.3e-05	10.743	-12.3	7.8e-35	0.36	0.24	0.10	FALSE
40	GTEx	Whole Blood	C7orf73	0.08	0.01	lasso	3	0.01	1.8e-02	11.782	-11.5	2.3e-30	0.35	0.14	0.11	FALSE
41	METSIM	Adipose	C7orf73	0.11	0.05	lasso	7	0.07	7.5e-11	7.289	-11.1	1.2e-28	0.27	0.96	0.04	FALSE
42	NTR	Blood	SLC13A4	0.02	0.01	bslmm	490	0.01	1.6e-03	11.935	8.9	8.0e-19	-0.21	0.20	0.03	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	C7orf73	0.23	0.16	enet	28	0.26	1.4e-33	5.561	-10.4	1.6e-25	0.24	0.99	0.01	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PL-5283	0.24	0.10	lasso	4	0.17	2.2e-14	7.397	-11.4	3.0e-30	0.26	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	PL-5283	0.33	0.24	enet	14	0.24	1.5e-48	11.782	-12.6	1.2e-36	0.37	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC13A4	0.14	0.05	lasso	5	0.07	1.5e-13	11.782	12.6	1.5e-36	-0.30	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PL-5283	0.26	0.22	lasso	6	0.20	2.5e-10	11.782	-11.9	1.2e-32	0.30	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	PL-5283	0.52	0.40	lasso	4	0.42	6.8e-26	11.782	-12.2	4.2e-34	0.30	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC13A4	0.46	0.24	lasso	3	0.24	2.4e-14	11.782	12.4	3.5e-35	-0.30	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Esophageal Carcinoma	PL-5283	0.39	0.23	lasso	3	0.20	5.0e-07	11.782	-11.2	2.6e-29	0.28	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	PL-5283	0.34	0.09	enet	13	0.11	3.4e-04	11.782	-11.1	2.2e-28	0.22	0.00	0.98	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PL-5283	0.28	0.22	lasso	4	0.24	1.4e-26	11.782	-11.9	1.7e-32	0.28	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PL-5283	0.40	0.32	lasso	4	0.36	2.6e-42	11.782	-10.7	1.3e-26	0.27	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC13A4	0.35	0.08	blup	56	0.20	1.8e-22	11.782	10.5	1.3e-25	-0.23	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PL-5283	0.22	0.14	lasso	4	0.12	2.0e-07	11.782	-11.4	5.4e-30	0.29	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC13A4	0.27	0.04	enet	10	0.15	4.8e-09	11.782	11.8	5.5e-32	-0.25	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	PL-5283	0.35	0.28	lasso	5	0.28	1.2e-31	11.782	-11.8	3.4e-32	0.30	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC13A4	0.19	0.06	enet	15	0.09	3.8e-10	11.782	10.5	5.7e-26	-0.21	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PL-5283	0.34	0.18	lasso	2	0.15	1.2e-07	11.782	-11.7	1.4e-31	0.29	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	FAM180A	0.05	0.02	blup	55	0.02	9.1e-04	6.644	-7.4	1.6e-13	0.19	0.01	0.06	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	PL-5283	0.40	0.24	lasso	5	0.26	4.2e-30	11.782	-12.4	1.6e-35	0.29	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC13A4	0.20	0.11	enet	12	0.15	2.9e-17	11.782	9.6	5.3e-22	-0.23	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PL-5283	0.22	0.16	lasso	3	0.15	5.6e-17	11.782	-11.9	1.1e-32	0.30	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC13A4	0.14	0.01	enet	9	0.07	2.3e-08	2.682	10.8	2.3e-27	-0.24	0.02	0.89	TRUE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PL-5283	0.33	0.23	blup	49	0.24	1.3e-16	11.782	-10.8	3.6e-27	0.25	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC13A4	0.10	0.04	blup	57	0.06	6.7e-05	11.782	10.5	1.1e-25	-0.24	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PL-5283	0.50	0.34	enet	12	0.37	3.1e-16	11.782	-11.5	7.7e-31	0.25	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PL-5283	0.40	0.15	lasso	7	0.18	1.2e-07	11.782	-10.3	4.6e-25	0.29	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SLC13A4	0.33	0.16	lasso	3	0.16	5.5e-07	11.782	12.2	2.8e-34	-0.32	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	PL-5283	0.40	0.31	enet	7	0.33	3.8e-35	11.782	-12.0	3.3e-33	0.31	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC13A4	0.45	0.17	lasso	6	0.23	3.6e-24	11.782	12.5	8.8e-36	-0.31	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Rectum Adenocarcinoma	PL-5283	0.37	0.07	enet	7	0.22	5.5e-06	7.289	-10.9	1.3e-27	0.27	0.00	0.95	FALSE
73	The Cancer Genome Atlas	Rectum Adenocarcinoma	SLC13A4	0.55	0.21	lasso	3	0.17	7.1e-05	11.782	11.9	7.6e-33	-0.30	0.00	0.98	FALSE
74	The Cancer Genome Atlas	Soft Tissue Sarcoma	NUP205	0.07	0.05	lasso	4	0.04	2.7e-03	11.365	-10.9	1.2e-27	0.27	0.01	0.62	FALSE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	PL-5283	0.20	0.12	lasso	2	0.11	5.1e-07	11.782	-12.3	5.6e-35	0.27	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PL-5283	0.48	0.03	lasso	4	0.15	7.7e-05	11.782	-10.7	8.0e-27	0.23	0.00	0.92	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	PL-5283	0.28	0.20	lasso	5	0.19	1.5e-13	11.782	-11.1	7.9e-29	0.28	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC13A4	0.31	0.17	lasso	5	0.24	3.4e-17	11.782	12.3	1.7e-34	-0.30	0.00	1.00	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PL-5283	0.40	0.26	enet	9	0.23	1.5e-08	11.782	-11.7	1.6e-31	0.30	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	PL-5283	0.59	0.38	lasso	6	0.42	1.5e-44	11.782	-12.6	3.3e-36	0.32	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	SLC13A4	0.44	0.18	blup	56	0.24	2.0e-23	11.782	12.3	1.1e-34	-0.31	0.00	1.00	FALSE