Hub : Genes

WDR91

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0450 0.0210 7.0e-03 0.023 0.023 0.035 0.020 0.030 8.0e-04 6.7e-04 3.4e-05 1.4e-03 1.4e-04
2 GTEx Adrenal Gland 0.3357 0.0780 4.4e-07 0.169 NA 0.072 NA 0.115 1.1e-06 NA 1.4e-03 NA 6.5e-05
3 GTEx Cells EBV-transformed lymphocytes 0.1390 0.0570 4.9e-03 0.148 NA 0.020 NA 0.111 1.5e-05 NA 7.5e-02 NA 1.8e-04
4 GTEx Cells Transformed fibroblasts 0.0890 0.0310 4.1e-04 0.015 NA 0.023 NA 0.023 2.6e-02 NA 7.3e-03 NA 7.4e-03
5 GTEx Esophagus Mucosa 0.1410 0.0360 2.2e-07 0.106 NA 0.120 NA 0.101 1.6e-07 NA 2.1e-08 NA 3.1e-07
6 GTEx Lung 0.1250 0.0422 1.3e-04 0.078 NA 0.046 NA 0.072 1.4e-06 NA 1.8e-04 NA 3.6e-06
7 GTEx Skin Not Sun Exposed Suprapubic 0.0840 0.0380 7.9e-03 0.014 NA 0.013 NA 0.005 5.3e-02 NA 5.9e-02 NA 1.7e-01
8 GTEx Skin Sun Exposed Lower leg 0.0850 0.0310 4.1e-04 0.040 NA 0.019 NA 0.029 2.6e-04 NA 8.7e-03 NA 1.9e-03
9 GTEx Stomach 0.1530 0.0550 5.8e-04 0.104 NA 0.062 NA 0.085 1.2e-05 NA 6.6e-04 NA 7.2e-05
10 GTEx Thyroid 0.1100 0.0400 1.6e-03 -0.004 NA 0.010 NA -0.004 9.0e-01 NA 5.1e-02 NA 9.3e-01
11 METSIM Adipose 0.0796 0.0219 4.4e-10 0.075 0.068 0.075 0.071 0.085 2.7e-11 2.3e-10 2.1e-11 7.4e-11 1.1e-12
12 NTR Blood 0.0411 0.0109 1.1e-11 0.047 0.037 0.050 0.032 0.028 6.0e-15 5.7e-12 6.9e-16 1.0e-10 1.9e-09
13 ROSMAP Brain Pre-frontal Cortex 0.0667 0.0206 1.5e-06 0.076 0.049 0.054 0.061 0.070 5.7e-10 6.1e-07 1.6e-07 3.0e-08 2.6e-09
14 YFS Blood 0.0259 0.0090 7.5e-06 0.009 0.018 0.022 0.018 0.018 5.4e-04 1.1e-06 5.7e-08 1.2e-06 7.9e-07
15 TCGA Cervical Squamous Cell Carcinoma 0.0720 0.0380 2.6e-03 0.024 0.047 0.024 NA 0.024 2.2e-02 2.4e-03 2.4e-02 NA 2.3e-02
16 TCGA Head and Neck Squamous Cell Carcinoma 0.0260 0.0168 6.4e-03 -0.002 0.006 -0.001 NA -0.002 6.7e-01 5.7e-02 4.9e-01 NA 9.5e-01
17 TCGA Kidney Renal Clear Cell Carcinoma 0.1987 0.0789 8.4e-07 0.027 0.052 0.061 NA 0.020 4.1e-04 1.6e-06 2.1e-07 NA 2.1e-03
18 TCGA Kidney Renal Papillary Cell Carcinoma 0.1620 0.0590 9.0e-13 0.224 0.214 0.231 NA 0.256 5.6e-13 1.9e-12 2.0e-13 NA 7.5e-15
19 TCGA Brain Lower Grade Glioma 0.0497 0.0323 1.3e-03 0.022 0.023 0.018 NA 0.026 1.3e-03 1.2e-03 3.3e-03 NA 5.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 1.9 3.0 8.3 -2.6 0.1 2.3 -1.6 0.9 0.8 2.8 2.9 0.6 2.0 0.8 2.5 -0.3 1.8 2.1 2.2 -0.2 -1.0 -0.0
Bipolar Disorder or Schizophrenia 2.0 4.9 13.6 -2.3 0.4 2.5 -2.7 2.1 1.9 3.4 3.7 1.4 3.2 1.5 3.0 -0.2 1.7 1.9 2.9 -0.7 -1.4 0.6
Depressed Affect (Nagel 2018) 0.1 0.3 1.8 0.7 -0.0 -0.5 -0.7 -0.0 0.1 -0.3 -0.4 0.1 1.4 0.0 -0.5 0.3 1.1 -0.4 -0.4 0.6 0.1 0.5
Depression (Nagel 2018) 0.2 0.3 1.1 0.5 -0.4 0.1 -0.2 -0.4 -0.1 0.1 0.5 -0.6 1.0 -1.1 -0.1 -0.3 -0.9 0.2 -0.5 -0.0 0.4 -0.5
Intelligence (Savage-Jansen 2018) 0.8 2.4 7.0 -0.4 2.1 1.1 -2.6 2.1 2.1 1.3 1.0 1.3 -0.7 1.4 0.9 2.0 1.0 -0.1 1.5 -1.9 -2.1 0.9
Neuroticism (Nagel 2018) 0.3 0.7 1.7 1.2 0.7 -0.3 -1.2 0.6 0.9 0.0 -0.1 1.1 1.2 0.7 -0.3 1.3 0.8 -0.7 0.2 0.6 -0.9 0.8
Schizophrenia (2018) 1.1 2.3 6.1 -0.8 0.5 1.4 -2.2 1.9 1.8 2.0 2.4 1.3 2.5 1.2 1.8 0.1 0.8 0.8 1.9 -0.7 -1.0 0.8
Schizophrenia vs Biploar Disorder 1.0 1.3 8.7 3.0 0.1 -1.6 1.0 -0.1 0.8 -1.5 -1.0 0.5 0.4 0.5 -1.1 0.6 -0.7 -1.8 -1.0 0.5 0.4 1.2
Worry (Nagel 2018) 0.7 1.6 4.1 1.5 1.3 -0.1 -1.0 1.4 1.7 0.2 0.1 1.9 0.9 1.7 -0.2 2.0 0.7 -1.4 0.7 0.4 -1.5 1.8
Alzheimer’s Disease (in mother) 0.3 0.4 1.4 -0.8 -0.6 0.0 0.7 -0.6 -0.8 0.1 -0.1 -0.6 -1.2 -0.2 0.2 -1.0 0.9 0.8 -0.3 0.5 0.5 -0.6
Alzheimer’s Disease (in father) 0.3 0.3 1.1 0.5 0.5 -0.5 1.1 0.1 0.1 -0.5 -0.7 0.3 0.3 0.9 -0.6 0.4 0.7 -1.0 0.1 -0.2 -0.2 1.0
Alzheimer’s Disease (including proxy) 0.8 1.2 2.8 -0.5 -1.0 -1.0 1.5 -1.4 -1.7 -1.1 -1.5 -1.4 -0.9 -0.7 -0.7 -1.3 0.3 -0.2 -1.3 0.9 1.5 -0.3
Crohns Disease (2017) 0.5 1.0 3.0 1.0 -0.7 -1.5 0.1 -0.1 -0.9 -1.2 -1.4 -0.3 0.7 -0.2 -1.5 0.1 -1.7 -1.1 -1.2 1.4 0.7 0.2
Irritable Bowel Disease (IBD) 0.5 1.1 4.4 1.7 0.2 -1.6 0.8 0.2 -0.4 -1.2 -1.1 0.9 -0.0 0.8 -1.2 1.2 -0.5 -2.1 -0.6 0.5 0.0 1.5
Ulcerative Colitis (UC) 1.0 1.8 7.2 2.0 1.1 -1.5 1.7 0.0 -0.0 -1.2 -0.9 1.2 -0.9 1.5 -1.0 1.7 0.6 -2.7 -0.2 -0.1 -0.3 2.3
Major Depression (MDD) 0.4 0.5 1.3 0.2 0.9 0.3 0.8 0.5 -0.0 0.8 0.7 0.6 0.7 1.1 0.6 0.7 1.1 -0.5 1.0 0.0 -0.9 1.0
Reaction Time 0.8 1.5 3.3 -1.0 0.9 1.7 -0.6 1.5 1.7 1.8 1.8 1.2 0.3 0.6 1.7 0.7 0.5 1.0 1.6 -1.0 -1.5 0.0
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.7 -0.7 0.7 -0.0 -0.9 0.5 0.3 0.0 -0.3 0.0 0.3 0.3 -0.3 0.7 -0.2 -0.4 0.1 -0.0 -0.4 0.3
Breast Cancer 0.9 2.2 5.6 1.8 2.4 1.1 -1.4 1.3 1.7 1.3 1.1 1.5 -0.2 2.1 1.1 1.7 0.8 -0.2 1.9 -0.7 -2.0 1.3
Ovarian Cancer 0.7 0.9 3.8 1.7 0.1 -1.2 2.0 -1.2 -0.5 -1.1 -0.9 -0.8 0.4 -0.1 -0.8 -0.1 0.4 -0.9 -1.1 0.2 1.0 0.7
Prostate Cancer 0.4 0.6 1.3 -0.1 -0.9 -1.1 0.8 -0.8 -0.4 -1.2 -1.0 -0.5 0.7 -0.5 -1.0 -0.7 0.6 -0.0 -1.1 0.5 1.0 -0.3
Age at First Birth 0.3 0.4 1.0 -0.8 -0.4 0.4 -0.3 -0.9 -0.6 0.1 0.4 -0.8 -0.9 -0.5 0.9 -0.7 -0.4 1.0 0.3 -0.4 0.3 -0.5
Bipolar Disorder (2011) 2.8 2.7 7.7 -2.1 -0.6 2.4 -2.0 0.4 -0.0 2.7 2.8 -0.3 1.5 -0.8 2.6 -1.0 0.4 2.5 1.5 0.3 -0.3 -1.2
Body Mass Index (BMI) (2010) 1.3 1.8 4.1 -1.2 -1.9 1.5 -1.4 -0.8 -0.9 1.2 1.1 -1.2 -1.6 -1.5 1.8 -1.6 0.6 2.0 0.1 -1.2 0.7 -1.8
Coronary Artery Disease (CAD) 0.5 0.6 2.9 -0.9 0.2 1.3 -1.7 0.7 0.3 1.1 0.8 0.6 -0.3 -0.2 1.1 0.3 -0.2 0.6 0.6 -0.4 -0.8 -0.5
Crohns Disease (2012) 0.4 0.6 2.3 0.3 0.0 0.5 -1.5 0.9 0.0 1.1 0.8 0.9 1.1 0.8 0.7 0.8 -0.3 0.1 0.8 1.0 -0.9 0.3
Mean Putamen Volume 0.4 0.5 1.8 0.1 -0.4 -0.1 -0.1 -1.1 -0.2 -0.1 0.2 -0.8 0.3 -1.2 0.1 -0.9 -1.3 0.4 -0.8 0.5 0.9 -1.2
Fasting Glucose 1.0 1.2 2.6 0.1 -1.3 0.1 0.5 -1.6 -1.4 0.0 0.3 -1.3 -0.6 -1.5 0.6 -1.6 -1.5 0.8 -0.6 1.1 1.3 -1.4
HbA1C 0.5 0.5 2.0 -0.9 -0.8 0.6 -0.5 -0.3 -0.4 0.3 0.6 -1.4 -0.9 -0.8 0.7 -1.3 0.1 0.8 -0.1 -0.3 0.9 -0.5
HDL Cholesterol 2.0 3.3 10.0 3.0 1.3 -2.5 2.1 -0.0 0.2 -2.3 -2.4 1.0 1.8 1.5 -2.6 1.4 -0.3 -3.2 -0.8 0.5 -0.1 2.0
LDL Cholesterol 0.7 1.2 2.8 -0.5 0.7 0.7 -1.7 1.6 1.1 0.8 0.7 1.7 -1.5 0.8 0.8 1.3 1.3 0.3 1.1 0.1 -1.4 0.3
Lupus 0.7 1.0 2.6 0.4 -0.2 -1.5 -0.3 0.2 -0.2 -1.6 -1.6 0.2 0.2 0.8 -1.6 0.5 1.2 -1.5 -0.8 -1.2 0.4 1.5
Neuroticism (2016) 0.4 0.6 2.2 0.9 0.1 -0.6 0.0 -0.0 0.3 -0.7 -0.5 -0.6 -1.2 -0.0 -0.5 0.4 1.5 -1.1 -0.7 -1.4 0.2 0.8
Primary Biliary Cirrhosis 1.0 1.5 4.4 -0.6 -0.2 1.6 -2.0 0.5 -0.5 1.9 2.1 -0.4 0.0 0.3 2.0 -0.7 1.6 1.1 1.3 1.5 -0.2 -0.1
Rheumatoid Arthritis 2.1 3.0 8.6 1.8 1.4 -2.3 1.9 0.7 1.1 -2.1 -1.9 1.6 -0.6 1.7 -2.2 2.1 -1.5 -2.9 -0.7 0.8 -0.8 2.2
Schizophrenia (2014) 2.0 4.4 12.3 -0.8 0.8 2.5 -2.5 2.5 2.2 3.1 3.5 1.6 2.6 1.6 2.9 0.3 1.2 1.4 2.9 -1.0 -1.8 0.7
Triglycerides 1.8 2.9 8.5 -2.1 -2.6 -0.2 -0.1 -1.9 -2.0 -0.5 -0.9 -2.1 -1.2 -2.9 -0.6 -2.1 -0.3 1.5 -1.6 0.7 2.1 -2.6
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.7 -0.9 -0.3 0.8 -0.4 -0.2 0.2 1.0 1.2 -0.2 -1.3 -0.4 1.2 -0.5 0.0 0.9 0.3 -1.0 0.1 -0.5
Ulcerative Colitis 1.4 2.0 7.3 1.9 1.2 -1.8 1.4 0.3 -0.1 -1.1 -0.8 1.2 -0.5 1.7 -1.1 1.7 0.5 -2.7 -0.4 0.9 -0.2 2.7
Blood Eosinophil Count 1.8 13.8 24.6 -0.9 3.1 4.7 -4.3 5.0 4.2 4.9 4.6 3.5 -3.4 2.6 4.4 2.7 -3.1 1.6 4.7 -3.1 -4.9 0.2
Blood Platelet Count 0.5 5.5 30.1 0.2 -0.4 -3.4 2.0 -0.5 -0.9 -3.0 -2.9 -0.8 -3.0 -0.3 -3.1 -0.0 -5.5 -2.6 -2.8 1.7 1.7 1.1
Blood Red Count 1.4 13.7 30.1 3.5 5.4 -3.1 2.6 2.9 5.3 -2.7 -2.2 4.5 1.4 5.1 -3.3 4.9 -0.7 -5.5 0.7 -2.0 -3.2 5.0
Blood White Count 0.5 3.5 22.8 -2.1 -1.7 0.0 1.3 -0.5 0.3 -0.4 -0.4 -1.0 -2.8 -2.7 -0.5 -1.1 -4.8 1.0 -1.7 -1.7 0.9 -2.9
Heel T-Score 0.2 1.8 6.2 -1.0 -0.6 1.4 -1.0 -0.6 -0.5 1.1 1.0 -1.9 -2.5 -1.5 1.0 -1.4 -0.8 1.8 0.1 -1.0 0.4 -2.5
BMI 0.4 2.4 7.5 -0.6 -0.8 2.7 -1.5 0.1 1.2 2.4 2.2 -0.0 -0.4 -1.0 2.5 -0.6 0.3 2.3 1.0 -2.5 -0.6 -1.7
Height 0.2 3.5 26.4 2.8 1.3 -0.2 -1.8 -0.1 0.1 0.8 1.3 -1.4 5.1 2.2 1.0 0.7 1.3 -1.1 1.0 2.0 0.2 2.9
Waist Hip Ratio (WHR) 0.8 3.6 9.9 -1.4 0.1 2.9 -3.1 2.6 0.4 3.1 2.8 1.1 0.9 -0.2 2.5 0.0 -1.1 2.2 2.1 -0.3 -1.6 -1.3
Systolic Blood Pressure 1.8 9.2 18.3 -3.4 -4.3 -2.2 2.4 -3.2 -3.1 -2.4 -2.8 -2.8 2.5 -3.9 -2.4 -3.8 -1.3 0.9 -3.7 2.7 3.8 -3.7
Smoking Status 0.4 1.0 4.2 1.0 -0.2 -1.1 1.3 -0.6 -1.0 -0.8 -0.7 -0.2 1.9 -0.2 -0.9 -0.0 -1.4 -1.2 -0.8 2.1 0.6 0.3
Allergy or Eczema 2.4 6.2 15.2 1.1 3.9 0.8 -1.0 3.2 2.8 1.0 0.8 3.7 2.5 3.0 0.2 3.8 1.8 -1.8 2.9 -1.1 -3.6 2.6
Cardiovascular Disease 2.1 7.0 16.3 -1.9 -4.0 -1.0 0.6 -3.4 -3.5 -1.0 -1.8 -3.6 1.2 -3.5 -1.2 -3.6 -2.2 1.2 -3.3 1.9 3.8 -2.8
Hypothyroidism (self reported) 1.8 4.1 9.5 -0.5 1.8 2.7 -1.4 2.2 1.9 2.5 2.3 2.3 0.2 1.8 2.4 1.7 1.8 1.0 3.1 -2.6 -2.7 0.9
Respiratory disease 0.3 0.7 1.9 -0.8 0.6 0.6 -1.3 1.4 0.0 0.7 0.5 0.7 0.2 1.0 0.4 0.4 1.4 -0.0 1.2 -0.1 -0.7 0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.5 1.2 0.2 -0.1 -0.7 1.0 1.1 -0.0 -0.1 -0.0 0.4 0.1 0.2 0.5 -1.0 -0.7 -0.1 -0.3 -0.5 0.1
Lung FEV1/FVC ratio 1.9 9.4 30.1 3.0 4.9 -1.0 -0.3 3.2 5.5 -1.1 -0.7 3.9 -1.9 3.2 -1.1 4.6 0.7 -3.3 1.1 -4.1 -3.6 2.9
Lung FVC 0.7 3.8 13.4 -3.7 -2.3 1.8 -0.2 -1.6 -1.2 1.4 1.7 -2.4 -0.0 -2.1 1.8 -2.6 0.8 3.3 0.3 0.2 1.1 -2.8
Neuroticism 0.4 0.9 2.1 1.2 1.1 0.6 -1.4 0.9 0.9 0.8 0.4 1.3 0.9 1.0 0.5 1.3 0.8 -0.3 0.7 0.2 -1.3 0.7
Chronotype (morning person) 0.9 2.2 6.2 -1.9 -2.5 -0.5 -0.3 -0.9 -1.6 -0.1 -0.1 -1.6 0.6 -2.2 -0.4 -1.7 -1.6 1.2 -1.4 2.0 1.8 -1.9
Hair Pigment 0.1 2.8 7.1 0.4 -2.2 -1.4 1.4 -1.9 -2.7 -1.5 -1.9 -1.4 1.2 -1.9 -1.5 -1.6 -1.7 -0.2 -2.1 1.1 2.2 -1.2
Tanning 0.2 2.4 6.5 1.9 1.6 -1.9 1.9 0.5 0.9 -1.8 -1.3 1.2 -0.3 2.1 -1.8 1.8 0.6 -2.5 0.0 0.5 -0.7 2.6
Hand grip strength (left) 0.0 0.1 0.3 0.0 -0.2 0.1 -0.3 -0.0 -0.1 -0.1 0.1 -0.5 -0.5 0.1 0.3 -0.4 0.5 0.5 0.4 -0.4 0.2 -0.0
Number of treatments/medications taken 0.6 1.1 4.3 0.3 0.9 0.6 -1.0 1.2 1.1 1.1 1.4 1.4 2.1 1.2 0.9 0.8 0.7 -0.2 1.1 0.2 -0.9 1.2
Average weekly spirits intake 0.6 0.8 2.8 0.7 1.1 -1.2 -0.4 0.9 1.0 -0.7 -0.7 0.7 1.7 0.6 -1.2 1.0 -0.6 -1.2 -0.2 0.3 -0.3 0.7
Sensitivity / hurt feelings 0.3 0.5 2.9 -0.0 -0.8 -0.6 -0.8 0.1 0.2 -0.5 -0.8 0.5 1.7 -0.9 -1.0 0.2 -0.5 0.2 -1.0 0.4 0.0 -1.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 3.5 1.9 0.6 -0.2 -0.6 0.5 0.8 0.1 0.7 0.1 -0.0 0.6 0.3 0.7 0.6 -0.9 -0.1 -0.2 -0.3 1.4
Hearing difficulty/problems: Yes 0.3 0.5 3.1 -1.8 -0.0 -0.0 0.9 -0.4 0.3 0.0 0.0 -0.2 1.5 -0.3 -0.3 -0.6 0.8 0.5 -0.2 0.5 0.1 -0.8
Relative age of first facial hair 0.7 1.5 4.2 1.6 1.3 -1.9 1.0 0.0 0.1 -1.3 -1.2 0.5 1.1 1.2 -1.8 1.2 -0.2 -1.8 -0.5 2.1 -0.3 1.3
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 4.5 -0.5 1.0 1.9 -2.1 1.7 1.7 2.1 1.9 1.5 0.9 0.5 1.7 1.0 0.6 1.2 1.9 -0.9 -1.9 -0.3
Ever used hormone-replacement therapy (HRT) 1.9 2.4 5.2 0.1 1.5 1.4 -2.3 2.0 1.8 1.6 1.8 1.9 -1.3 1.5 1.6 1.3 0.2 -0.1 1.8 -2.0 -1.8 1.1
Ever had hysterectomy (womb removed) 1.0 1.1 5.3 -0.7 1.2 0.8 0.4 1.3 1.3 0.7 0.8 1.3 -0.8 1.0 0.4 0.9 1.2 -0.1 1.2 -2.3 -1.3 0.5
Systolic blood pressure, automated reading 0.4 1.3 3.2 -1.5 -1.8 -0.8 1.0 -0.8 -1.0 -0.8 -1.0 -0.7 0.8 -1.4 -1.0 -1.4 -1.0 0.6 -1.4 -0.4 1.1 -1.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.5 1.4 0.6 -0.6 0.8 0.6 1.6 -0.3 -0.5 1.2 1.2 0.5 -0.4 1.3 -0.7 -1.2 0.1 -0.6 -1.0 0.0
Angina 0.5 0.6 1.9 0.7 0.3 -1.1 0.4 0.5 0.4 -0.8 -0.5 0.3 1.2 0.5 -0.9 0.8 -1.3 -1.4 -0.4 0.8 -0.1 1.0
Medication for hormone replacement therapy 1.8 2.0 5.0 2.2 1.9 0.5 -0.1 1.6 1.6 0.7 1.1 1.9 -0.6 1.6 0.6 1.9 0.9 -1.1 1.4 -1.4 -1.6 1.9
Vitamin and mineral supplements 0.7 1.0 2.4 -0.2 -1.2 -0.7 0.3 -1.2 -0.7 -0.9 -1.6 -1.1 -0.0 -1.2 -1.3 -0.8 -1.0 0.3 -1.3 0.8 0.9 -1.3
Supplements: Zinc 0.6 0.7 1.8 0.3 0.6 0.8 -0.9 1.1 0.1 1.0 1.4 0.8 -0.6 0.7 1.2 0.6 0.9 0.3 1.0 -0.6 -0.9 0.5
Medication: Co-codamol 0.7 0.8 2.0 -0.3 1.1 1.2 -0.8 0.5 1.4 1.3 1.2 1.0 1.0 0.2 0.8 0.7 -0.4 0.4 1.2 -0.2 -1.0 -0.0
Medication: Metformin 1.2 1.7 4.8 1.5 1.1 1.0 -1.8 1.5 2.2 1.1 1.1 1.2 -0.7 1.0 1.2 1.4 0.5 -0.5 1.4 -1.6 -1.7 0.6
Diabetes (father) 0.4 0.5 1.5 0.5 0.6 -0.5 0.5 0.6 0.6 -0.4 -0.6 1.2 -0.2 0.7 -0.8 1.1 -0.6 -0.8 0.2 -0.7 -0.8 0.6
Diabetes (mother) 0.6 0.7 2.1 0.8 1.1 0.5 0.0 1.0 0.7 0.3 0.2 0.7 -0.2 1.3 0.4 0.6 1.1 -0.7 1.0 -1.5 -1.0 1.2
Severe depression (siblings) 1.1 1.2 3.9 1.3 1.2 1.0 -0.3 1.4 1.5 0.9 0.5 2.0 0.3 1.0 0.5 1.4 -0.7 0.1 1.2 -1.0 -1.7 0.1
Pack years adult smoking proportion 1.9 2.9 9.4 -3.1 -1.2 2.2 0.4 -0.5 -1.5 2.0 2.5 -1.2 -1.7 -1.6 2.3 -1.5 -0.2 2.7 1.0 -0.7 0.4 -1.9
Impedance of leg (right) 0.3 1.5 10.0 -1.2 0.7 0.4 -1.6 0.9 0.1 1.0 1.5 0.8 3.2 0.4 0.8 0.1 0.7 0.5 1.0 2.4 -0.4 0.4
Leg fat-free mass (left) 0.2 1.0 4.5 1.0 -1.4 0.7 -0.6 -1.4 -1.0 0.6 0.4 -2.1 -0.8 -1.0 0.9 -1.2 0.2 1.0 -0.5 -0.9 1.1 -0.7
Trunk fat percentage 0.8 3.1 10.7 0.3 -0.3 3.3 -1.9 -0.2 0.7 3.0 2.5 -0.7 -1.9 -1.1 3.0 -0.7 -0.3 2.4 1.2 -2.1 -0.7 -1.7
Hand grip strength (right) 0.1 0.2 0.5 -0.7 0.1 0.3 -0.7 0.2 0.1 0.3 0.5 -0.3 -0.7 0.0 0.3 -0.4 0.2 0.7 0.4 -0.4 0.1 -0.3
Townsend deprivation index at recruitment 1.2 1.7 4.9 0.5 1.7 1.4 -0.2 1.5 1.2 1.4 1.1 1.9 -0.9 1.0 1.3 1.9 0.9 -0.2 1.5 -0.9 -2.2 0.4
Current tobacco smoking 0.4 0.6 1.7 -0.8 0.6 1.3 0.3 0.8 -0.2 1.2 1.3 0.5 -0.2 0.1 1.3 0.3 0.2 0.7 1.0 -0.1 -0.9 -0.4
Average weekly fortified wine intake 0.8 1.0 1.9 -1.2 -1.4 -0.1 0.3 -1.1 -1.1 -0.1 -0.1 -1.3 0.2 -1.3 -0.5 -1.3 -1.0 1.1 -0.8 1.2 1.2 -1.2
Maternal smoking around birth 0.3 0.4 2.9 0.8 0.4 1.0 -0.0 0.5 0.5 0.7 0.6 -0.2 -0.6 -0.0 0.6 0.0 1.1 0.2 0.3 -1.7 -0.3 0.2
Fed-up feelings 0.4 0.7 4.5 1.2 0.3 -1.0 0.1 0.1 -0.2 -0.7 -0.6 0.1 1.0 0.5 -0.7 0.5 2.1 -1.1 -0.6 0.5 0.2 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.6 -0.3 -1.4 -0.5 0.3 -1.0 -1.0 -0.4 0.1 -1.4 0.7 -1.6 -0.3 -1.2 -1.1 0.2 -1.4 0.8 1.4 -0.8
Relative age voice broke 0.7 1.1 3.7 0.8 0.6 -1.9 1.3 0.0 0.7 -1.5 -1.0 1.0 1.3 0.7 -1.7 1.0 -0.6 -1.4 -0.8 1.1 -0.1 0.6
Taking other prescription medications 0.5 0.8 2.7 0.3 0.7 0.6 -0.3 1.3 0.8 0.9 1.0 1.3 1.6 1.0 0.6 1.0 -0.5 -0.5 1.0 -0.3 -1.0 1.0
Age when periods started (menarche) 0.5 1.3 5.1 0.1 1.3 0.8 -1.1 1.6 1.1 0.8 1.0 1.2 0.4 1.1 0.7 0.9 2.2 0.2 1.4 -1.4 -1.2 1.0
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.2 -0.4 -0.4 -0.4 0.4 -0.2 -0.2 0.1 -0.1 -0.1 -0.6 -0.3 -0.1 -0.0 0.0 -0.7 -0.4 0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.1 -0.1 0.5 1.0 -1.5 0.8 0.9 1.1 1.2 0.6 -1.2 0.3 1.2 0.6 0.2 0.9 1.2 -1.3 -1.1 -0.6
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.7 -0.7 0.3 1.9 -2.2 1.1 0.8 1.8 1.4 0.3 0.4 -0.9 1.5 0.1 -1.0 1.7 1.0 -1.4 -1.0 -1.6
Qualifications: CSEs or equivalent 0.2 0.2 1.8 0.3 0.5 0.0 -0.1 0.3 -0.7 -0.0 0.3 -0.1 -1.4 0.5 0.4 -0.0 0.2 -0.5 0.1 0.2 0.1 1.0
Serious illness, injury or assault to yourself 0.2 0.2 1.0 -0.9 -0.7 0.1 -0.6 0.1 0.8 0.0 -0.2 0.4 1.0 -0.5 -0.1 0.3 0.2 -0.0 -0.6 -0.1 -0.2 -0.5
High blood pressure 0.9 2.5 6.6 -1.1 -2.6 0.3 -0.4 -1.8 -2.0 0.2 -0.3 -2.5 -0.5 -2.2 0.2 -2.5 -1.7 1.3 -1.4 0.2 2.0 -1.9
Hayfever, allergic rhinitis or eczema 1.3 2.7 7.0 -0.1 2.5 -0.0 -0.4 2.2 2.0 0.0 0.0 2.5 2.4 1.9 -0.3 2.7 1.0 -1.6 1.5 -0.3 -2.2 1.9
Multivitamins +/- minerals 0.6 0.7 2.6 -0.3 0.6 1.2 0.0 0.3 0.4 1.2 1.5 0.7 -0.3 0.6 1.6 -0.0 1.1 0.8 1.2 -0.8 -0.7 0.0
Stomach or abdominal pain in last month 0.4 0.5 2.2 -1.5 -0.8 -0.1 -0.8 -0.3 -0.9 -0.3 0.1 -1.3 -0.0 -1.0 -0.2 -1.0 0.1 0.1 -0.7 -0.7 1.0 -0.3
Supplements: Glucosamine 0.1 0.2 0.9 0.1 -0.4 0.4 -0.5 -0.2 -0.5 0.4 0.0 0.7 0.3 -0.1 0.3 0.3 -0.9 0.3 0.2 0.6 -0.3 -0.3
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 7.3 -1.5 -1.6 1.9 -1.8 -0.4 0.1 1.8 1.5 -0.7 2.1 -1.2 1.7 -2.0 0.8 2.7 0.6 -0.5 0.5 -1.9
Medication: Atenolol 0.5 0.7 1.7 1.3 -0.5 -0.9 0.9 -0.6 -0.0 -1.1 -1.1 -0.3 1.0 -0.7 -1.1 0.2 -0.9 -1.1 -1.1 0.2 0.5 -0.3
Medication: Levothyroxine sodium 0.8 1.3 2.8 0.2 0.6 1.7 -0.7 1.1 0.7 1.6 1.3 1.5 -0.8 0.7 1.7 1.0 -0.4 0.5 1.7 -1.4 -1.6 0.0
Sitting height 0.4 2.6 12.5 0.5 -1.7 0.2 -2.4 -1.4 -1.5 0.6 1.2 -3.1 3.5 -1.0 1.1 -1.7 0.1 0.9 -0.7 1.6 1.8 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 3.0 -1.1 -1.7 0.1 -1.0 -0.3 -1.7 0.3 0.4 -1.3 -0.3 -1.3 0.2 -1.6 -0.7 1.0 -0.7 1.5 1.4 -0.6
High blood pressure (mother) 1.7 2.4 5.0 -0.4 -1.8 -1.4 1.0 -2.0 -1.7 -1.6 -1.6 -1.9 1.9 -2.0 -1.5 -1.5 -0.2 -0.4 -2.0 0.8 2.2 -1.0
Body mass index (BMI) 0.9 3.7 10.3 -0.5 -1.2 3.1 -1.7 -0.1 0.2 2.6 2.0 -0.6 -3.2 -1.6 2.6 -1.1 -0.8 2.8 0.8 -2.8 -0.4 -2.5
Impedance of leg (left) 0.3 1.6 9.7 -1.6 0.5 0.8 -1.5 0.6 0.1 1.3 1.6 0.5 3.1 0.2 1.0 -0.1 0.7 0.8 1.1 2.4 -0.4 0.0
Leg predicted mass (left) 0.2 1.0 4.5 1.1 -1.4 0.6 -0.5 -1.4 -1.0 0.5 0.4 -2.1 -0.6 -0.9 0.8 -1.2 0.3 0.9 -0.6 -0.9 1.1 -0.6
Trunk fat mass 0.7 3.2 10.4 0.4 -0.7 3.2 -2.2 -0.4 0.3 3.0 2.5 -1.1 -1.5 -1.1 3.0 -1.0 -0.2 2.5 1.1 -1.9 -0.4 -1.7
Waist circumference 1.0 3.5 11.3 0.1 -0.5 3.4 -2.5 0.7 0.6 3.1 2.6 -0.2 -2.3 -0.9 3.0 -0.6 -0.7 2.5 1.3 -2.2 -0.9 -1.7
Number of incorrect matches in round 0.8 1.4 3.4 -1.7 -1.7 1.1 -0.3 -0.6 -0.6 0.6 0.9 -0.8 -0.8 -1.8 1.0 -1.5 -1.2 1.8 -0.4 -1.1 0.9 -1.8
Past tobacco smoking 0.5 0.8 2.9 -0.9 -0.7 1.0 0.1 -0.7 -0.2 0.7 1.1 -0.9 -1.2 -0.8 1.1 -1.3 0.4 1.7 0.3 -1.0 0.7 -0.9
Alcohol usually taken with meals 0.8 1.2 2.9 -0.0 -0.8 -1.6 1.0 -1.2 -0.4 -1.5 -1.4 -1.2 0.6 -0.9 -1.6 -0.8 0.5 -0.4 -1.4 1.7 1.3 -0.5
Nervous feelings 0.8 1.5 5.6 1.4 1.4 -0.2 -0.5 0.8 0.8 0.2 0.1 1.4 1.6 1.7 -0.2 1.3 2.4 -0.9 0.5 1.6 -0.9 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.5 0.5 0.5 -0.8 -0.3 1.0 0.8 -0.5 0.3 0.5 0.4 0.5 -0.3 0.9 0.9 -1.0 -0.3 0.1 -0.2 1.2
Hearing difficulty/problems with background noise 0.3 0.5 5.4 0.2 0.3 -0.1 -0.3 0.4 0.9 0.0 -0.4 0.2 2.3 0.1 -0.5 0.1 1.1 -0.0 -0.1 -0.4 -0.3 -0.4
Hair/balding pattern: Pattern 2 1.5 1.9 4.5 0.3 1.7 1.4 -1.5 2.1 1.6 1.1 1.3 1.7 -1.2 0.8 1.1 1.6 -0.2 0.2 1.5 -1.8 -2.0 0.3
Had menopause 1.1 1.3 3.3 0.2 0.7 1.8 -1.4 1.1 0.2 1.5 1.7 0.7 -1.4 0.8 1.7 0.4 0.5 0.5 1.6 -1.3 -1.1 0.6
Had other major operations 1.5 1.9 8.5 -1.9 -0.7 1.7 -2.9 -0.1 -0.6 1.7 1.6 -1.0 0.1 -1.3 1.6 -1.0 -1.0 2.0 0.4 0.6 0.3 -1.5
Forced vital capacity (FVC) 0.7 2.8 6.9 -2.4 -1.8 0.5 -0.1 -2.0 -1.8 0.7 1.0 -2.6 2.5 -1.6 0.9 -2.2 0.4 1.9 -0.5 2.0 1.6 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.8 0.3 0.5 0.7 -1.3 0.9 0.4 0.5 0.5 0.2 -2.0 0.0 0.6 0.5 0.2 0.6 0.6 -1.7 -0.9 -0.7
Ever unenthusiastic/disinterested for a whole week 2.6 3.1 6.7 0.7 2.6 1.0 -0.5 2.6 2.0 1.4 1.8 2.2 1.6 2.1 1.1 2.1 1.6 -0.5 2.4 -0.6 -2.4 1.6
Qualifications: None of the above 0.8 1.7 6.5 0.1 -1.5 -0.6 2.5 -1.8 -1.3 -1.2 -1.3 -1.2 -1.2 -1.5 -1.1 -1.3 -0.7 0.5 -1.5 -0.6 1.3 -1.2
Financial difficulties in last 2 years 0.3 0.4 2.9 0.0 -0.5 -0.3 0.3 -0.7 -0.0 -0.0 -0.4 -0.2 1.7 -0.4 -0.1 -0.1 -1.5 -0.1 -0.8 1.0 0.1 -0.6
Mouth/teeth dental problems 0.8 1.2 9.7 0.1 0.7 0.9 -1.2 0.9 0.5 0.9 1.5 0.8 0.6 1.0 1.4 0.1 3.1 0.4 1.2 -0.6 -0.6 0.7
Heart attack 0.5 0.6 4.7 0.1 -0.9 -0.3 0.6 -1.0 -1.0 -0.5 -0.6 -0.7 0.4 -1.0 -0.5 -0.4 -2.2 0.0 -0.7 0.1 0.7 -0.8
Allergy 0.8 1.9 5.1 1.4 -1.8 -0.6 0.5 -2.2 -1.6 -0.5 -0.4 -2.3 -1.2 -1.5 -0.3 -1.9 -1.0 0.7 -1.6 1.0 2.0 -1.2
Pain all over the body in last month 0.2 0.3 0.8 -0.4 0.3 -0.2 -0.7 0.9 0.9 -0.0 0.3 0.6 0.5 0.3 -0.3 0.4 -0.5 -0.4 -0.1 0.4 -0.1 0.9
Diabetes (self-reported) 1.3 2.1 7.8 2.8 1.6 0.4 -0.5 1.8 2.2 0.4 0.4 1.5 -0.4 1.7 0.6 1.9 -0.2 -1.5 1.1 -1.3 -1.9 1.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.3 0.4 1.7 -0.2 0.4 1.3 0.8 -0.2 -0.2 1.7 1.3 1.8 -0.5 1.5 -0.3 -1.3 1.0 0.3 -1.3 1.7
Medication: Ramipril 0.9 1.1 3.0 -0.1 -1.7 0.3 -0.7 -1.3 -1.2 0.3 -0.2 -1.5 -0.1 -1.7 0.5 -1.2 -1.2 1.0 -1.2 0.2 1.1 -1.6
Medication: Simvastatin 0.6 0.9 2.9 0.5 -1.2 -0.4 0.6 -1.1 -0.2 -0.4 -0.9 -0.8 1.6 -1.1 -0.5 -1.0 -1.7 0.3 -1.3 -0.1 1.0 -1.0
Fluid intelligence score 0.7 1.4 3.6 -0.9 1.6 0.2 -1.7 1.5 1.1 0.7 0.5 1.2 1.7 1.0 0.1 1.6 1.9 -0.6 0.8 0.2 -1.3 0.9
Illnesses of siblings 0.2 0.3 2.2 -0.6 0.5 -0.1 0.5 0.2 -0.0 0.2 0.5 0.0 0.2 1.0 0.2 0.3 1.5 -0.4 0.7 0.5 -0.3 1.1
Neuroticism score 0.8 1.6 3.5 1.4 1.7 -0.3 -0.9 1.3 1.2 0.2 0.2 1.7 1.6 1.8 -0.1 1.8 1.7 -1.2 0.6 0.5 -1.4 1.9
Weight 0.5 2.7 7.8 0.3 -1.0 2.8 -2.2 -0.5 -0.2 2.6 2.3 -1.4 -1.3 -1.0 2.7 -1.2 -0.2 2.4 0.8 -1.7 0.0 -1.5
Impedance of arm (right) 0.6 2.9 8.2 1.5 2.0 -2.5 2.2 -0.0 0.6 -2.3 -1.8 0.7 1.5 1.3 -2.2 1.8 0.1 -2.9 -0.8 2.0 -0.3 2.0
Arm fat percentage (right) 0.4 1.6 8.2 0.7 -0.2 1.9 -0.7 -0.2 0.5 1.5 1.1 -0.4 -2.9 -1.2 1.6 -0.2 -0.7 1.4 0.2 -2.0 -0.5 -1.7
Trunk fat-free mass 0.2 1.0 3.9 0.6 -1.4 0.5 -1.3 -1.0 -1.3 0.7 0.7 -2.0 0.6 -0.8 0.9 -1.4 0.1 1.1 -0.3 -0.1 1.2 -0.5
Hip circumference 0.2 0.8 3.3 1.0 -0.6 1.1 -0.2 -0.8 0.3 0.9 0.6 -1.2 -1.8 -0.9 1.0 -0.7 -0.6 0.8 -0.2 -1.4 0.4 -0.9
Time employed in main current job 1.1 1.3 3.2 -1.4 -1.5 0.3 -0.8 -0.5 -0.9 0.1 0.6 -1.8 -1.2 -1.7 0.6 -1.5 -1.4 1.5 -0.5 0.2 1.1 -1.6
Alcohol intake versus 10 years previously 0.6 0.9 4.5 -2.1 -0.5 1.4 0.1 0.0 0.3 1.2 0.6 0.0 -0.0 -0.9 0.8 -0.7 0.5 1.8 0.5 -0.5 -0.2 -1.5
Father’s age at death 0.6 0.8 2.6 1.6 1.0 -0.9 -0.1 1.1 1.1 -1.0 -0.7 0.9 0.7 0.6 -0.9 1.2 -0.3 -1.2 -0.0 -1.1 -0.8 0.6
Worrier / anxious feelings 0.8 1.5 3.5 1.3 1.5 0.8 -1.3 1.7 1.4 0.9 0.6 1.9 0.7 1.5 0.6 1.6 0.8 -0.3 1.3 -0.6 -1.8 1.1
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 6.2 0.3 1.5 2.0 -1.8 1.3 1.5 2.1 2.5 1.1 -0.2 1.1 2.3 0.9 1.4 0.8 2.1 -0.7 -1.7 0.4
Falls in the last year 0.5 0.7 3.5 -0.3 -0.4 1.0 -1.9 0.1 -0.2 1.1 1.4 0.0 0.8 -0.5 1.4 -0.2 0.4 0.8 0.6 0.4 -0.2 -0.7
Hair/balding pattern: Pattern 3 0.6 0.9 2.8 -0.9 -1.7 -0.3 -0.9 -0.9 -1.5 -0.1 -0.3 -0.8 0.8 -1.0 -0.1 -1.3 0.6 0.7 -0.8 0.9 1.3 -0.9
Number of live births 0.9 1.3 4.7 1.7 0.6 -1.8 0.4 0.2 1.0 -1.7 -1.5 0.7 0.2 0.5 -1.5 1.2 0.2 -2.2 -1.0 -0.6 -0.1 1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 1.8 -0.8 -0.3 0.2 0.2 -0.9 -0.3 0.0 0.4 -1.3 0.8 -0.6 0.3 -0.7 0.4 0.7 -0.2 0.3 0.4 -0.6
Pulse rate 0.3 0.6 1.6 -0.1 -1.2 0.3 0.3 -1.3 -0.9 0.2 -0.2 -1.0 -0.2 -1.0 0.4 -1.1 -0.8 0.2 -0.8 0.4 0.9 -0.9
Happiness 0.7 0.8 3.3 -0.0 -1.1 -0.4 0.7 -1.2 -1.0 -0.4 -0.4 -1.8 -0.7 -1.1 -0.2 -1.4 0.5 0.4 -1.0 0.6 1.3 -0.7
Noisy workplace 0.1 0.1 0.4 -0.2 0.1 -0.2 0.4 -0.4 -0.3 -0.2 -0.5 -0.2 -0.3 0.3 -0.1 -0.2 -0.6 -0.5 0.0 0.2 0.3 0.4
Qualifications: A levels/AS levels or equivalent 0.4 0.8 3.1 1.5 -0.0 -1.5 0.0 0.1 0.0 -1.1 -0.6 -0.7 1.6 0.0 -0.8 0.0 -0.2 -1.0 -0.8 1.8 0.6 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 2.0 0.4 -0.4 -0.0 0.0 -1.0 0.4 -0.4 -0.7 -0.2 -1.1 -0.8 -0.1 -0.2 -1.4 0.2 -0.5 0.2 0.1 -1.1
Mouth/teeth dental problems: Dentures 0.7 1.2 6.0 -0.4 -0.7 -0.3 1.6 -1.4 -1.5 -0.6 -1.1 -1.1 -0.4 -1.3 -0.8 -0.7 -2.4 0.3 -0.9 0.3 0.9 -1.2
Asthma 0.1 0.2 0.9 -0.4 0.1 -0.1 -0.2 0.8 0.0 -0.1 -0.3 0.4 -0.3 0.7 -0.2 -0.1 0.5 -0.6 0.2 -0.6 -0.0 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 4.6 -0.1 0.8 -1.0 0.6 1.2 1.0 -0.4 0.4 0.9 1.1 1.0 -0.2 1.0 2.2 -0.8 0.2 0.1 -0.5 1.2
Medication: Cholesterol lowering 1.8 2.8 5.6 0.7 -1.4 -2.1 1.2 -1.9 -1.2 -2.1 -2.4 -1.1 2.0 -1.2 -2.2 -0.8 -1.9 -1.1 -2.4 1.7 1.8 -0.5
Depression (self-reported) 0.4 0.5 1.4 0.9 0.5 0.9 -0.1 0.2 -0.3 1.0 1.2 0.4 -0.4 0.8 0.9 0.1 1.0 0.4 1.0 -0.3 -0.6 0.5
Medication: Lansoprazole 0.7 0.8 3.0 -0.1 -1.1 0.9 -0.2 -0.8 -1.7 0.8 0.1 -0.6 0.1 -1.2 0.4 -1.1 -1.4 1.3 -0.2 0.2 0.5 -1.7
Prospective memory result 0.4 0.5 2.5 -0.4 -0.8 0.8 -1.6 0.4 0.3 1.0 0.7 0.0 -0.4 -0.2 0.9 -0.7 -1.3 0.7 0.2 -0.5 0.1 -0.5
Lung cancer (father) 0.8 0.9 6.8 2.6 0.3 -0.6 1.8 -0.2 -0.6 -0.9 -1.1 -0.2 0.5 -0.3 -1.1 0.3 0.9 -1.1 -0.8 -0.0 0.3 0.5
Illnesses of mother 0.6 0.7 2.4 -1.0 0.6 0.2 -1.3 1.6 0.7 0.6 0.4 1.3 -0.9 0.5 0.1 1.0 -1.1 0.4 0.8 0.6 -1.1 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 2.0 -0.3 -0.2 1.1 -0.2 -1.0 -0.5 0.9 0.9 -1.4 0.7 -0.4 1.0 -0.7 0.6 1.1 0.3 0.1 0.2 -0.6
Pulse wave Arterial Stiffness index 2.3 2.7 7.9 -0.7 2.1 1.6 -1.0 2.2 2.8 1.2 1.7 2.0 -1.4 1.4 1.0 1.6 0.9 0.5 2.0 -1.8 -2.3 0.6
Impedance of arm (left) 0.5 2.5 7.1 1.7 2.5 -1.7 1.8 0.4 1.5 -1.5 -1.0 1.3 1.0 1.8 -1.5 2.1 0.4 -2.7 -0.1 1.4 -1.0 2.3
Arm fat mass (right) 0.5 2.2 6.2 0.5 -0.8 2.4 -1.3 -0.4 0.2 2.0 1.6 -0.9 -2.5 -1.4 2.1 -0.8 -0.6 2.0 0.3 -2.0 -0.2 -1.9
Trunk predicted mass 0.2 0.9 3.7 0.6 -1.4 0.4 -1.3 -1.0 -1.3 0.6 0.6 -1.9 0.5 -0.7 0.7 -1.3 0.1 0.9 -0.4 -0.1 1.2 -0.5
Standing height 0.2 1.9 13.9 1.4 0.0 -0.1 -1.3 -1.0 -0.8 0.6 1.0 -2.0 3.7 0.9 0.8 -0.5 1.2 -0.1 0.3 2.2 0.8 1.5
Length of working week for main job 0.8 0.9 2.3 -1.1 -0.7 1.0 -0.6 -0.4 -0.3 0.9 0.8 -1.1 -1.5 -0.9 1.1 -0.8 -0.9 1.4 0.1 -1.1 0.4 -1.1
Exposure to tobacco smoke at home 0.4 0.5 2.9 0.8 0.6 0.2 0.5 0.4 0.7 -0.3 0.2 0.8 -1.7 0.0 0.0 0.6 -1.0 -0.1 0.1 -1.6 -0.5 0.1
Breastfed as a baby 0.9 1.1 4.3 -0.7 0.8 1.0 -1.8 1.8 0.3 0.7 0.4 1.0 -2.1 0.4 0.5 0.8 -0.1 0.4 1.1 -1.3 -1.3 -0.1
Tense / ‘highly strung’ 0.7 1.2 5.8 0.9 0.7 -0.6 -0.6 1.3 1.0 -0.2 0.4 0.9 1.4 1.6 -0.1 1.4 1.2 -1.6 0.4 0.2 -0.7 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.7 0.2 1.3 0.3 -0.1 1.0 1.3 0.4 0.9 1.0 -0.3 1.1 0.4 1.2 0.6 -0.3 0.9 -1.2 -1.1 1.3
Hair/balding pattern: Pattern 4 0.4 0.9 7.1 1.6 0.7 -0.5 -0.5 -0.1 1.2 -0.1 0.1 0.7 2.7 0.7 -0.1 0.5 0.6 -1.3 0.2 0.1 -0.2 1.2
Birth weight of first child 2.7 4.8 9.9 0.3 1.9 2.8 -3.1 2.2 1.6 3.2 2.8 1.2 2.5 1.9 2.9 1.3 2.6 1.0 2.8 -1.3 -2.4 0.9
Peak expiratory flow (PEF) 0.4 0.9 5.5 1.1 1.0 -0.8 -0.1 0.2 0.6 -1.0 -0.9 0.7 -2.3 0.8 -0.8 1.2 0.1 -1.1 0.0 -0.8 -0.7 0.9
Pulse wave reflection index 0.8 1.0 3.2 -0.8 1.6 0.6 0.4 1.1 1.8 0.6 1.0 1.1 -0.4 1.2 0.4 0.8 1.2 0.4 1.3 -0.7 -1.2 0.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 4.0 -0.5 -1.0 0.2 -1.4 -0.4 -0.7 0.4 0.7 -0.4 -0.2 -0.9 0.7 -0.7 -2.0 0.6 -0.3 0.7 0.5 -1.1
Loud music exposure frequency 1.2 1.3 3.4 1.5 0.6 -1.8 0.9 -0.6 0.3 -1.8 -1.8 0.2 0.9 0.7 -1.5 0.5 0.2 -1.9 -1.1 1.0 0.5 1.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.4 0.6 -0.0 -1.0 -0.1 0.4 0.1 -0.9 -0.7 -0.2 1.1 -0.5 -1.0 -0.1 -0.1 -0.5 -0.8 1.2 0.4 -0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.3 1.4 -0.4 -0.5 0.1 -0.7 -0.7 -0.5 -1.1 -0.8 -0.3 -0.5 -0.9 0.1 -1.5 -0.8 -0.9 1.4 0.3 -0.2
Blood clot in the leg (DVT) 0.6 0.8 3.3 -0.0 1.0 1.0 -1.1 0.9 1.3 0.6 0.5 1.2 -0.4 0.2 0.8 1.1 -0.2 0.4 0.6 -1.8 -1.4 -0.4
Medication: Paracetamol 0.2 0.4 1.7 -0.0 0.3 0.2 -0.3 1.1 0.5 0.4 0.3 1.3 -0.1 0.1 0.2 0.8 -1.2 -0.1 0.1 0.7 -0.7 0.2
Headache pain in last month 0.4 0.7 5.0 0.6 0.7 0.8 -0.0 0.8 0.4 0.5 0.9 0.6 -0.6 0.7 0.7 0.8 2.2 0.0 0.9 -0.3 -0.9 0.8
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 6.7 -0.1 2.3 1.5 0.1 2.3 2.0 1.3 1.3 2.4 -1.5 1.9 1.0 2.0 1.8 0.2 2.2 -1.8 -2.6 1.0
Glaucoma (self-reported) 0.6 0.7 2.2 1.2 0.5 -0.9 1.5 -0.2 1.1 -0.9 -0.8 0.1 1.2 0.5 -1.0 0.8 0.1 -1.3 -0.3 -0.6 -0.3 0.7
Gout (self-reported) 0.9 1.2 5.2 -0.4 -1.1 -0.1 0.1 -1.2 -0.8 -0.2 -0.5 -1.5 2.3 -1.5 -0.6 -1.4 0.0 1.0 -1.0 1.4 1.1 -1.6
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 7.4 -0.1 1.7 1.9 -1.0 2.2 1.7 2.0 1.8 2.4 -0.3 1.9 1.9 1.8 0.9 0.2 2.7 -1.6 -2.5 1.2
Medication: Amlodipine 0.1 0.2 1.1 1.0 0.3 0.3 0.0 -0.5 0.5 0.1 0.3 -0.2 0.5 0.5 0.4 0.2 -0.3 -0.5 0.2 -0.4 -0.2 0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.2 0.7 0.9 0.7 -1.2 1.0 1.5 0.9 0.9 1.1 1.5 1.1 1.0 0.6 1.3 -0.5 0.9 -1.3 -1.0 0.9
Birth weight 1.1 2.5 6.8 -1.2 -1.8 1.9 -1.6 -1.3 -1.3 2.1 1.7 -0.8 0.9 -1.5 2.3 -1.0 -0.8 2.6 0.5 1.7 0.4 -2.1
Chronic bronchitis/emphysema (mother) 0.2 0.3 2.0 0.6 0.0 0.7 -1.4 0.3 0.5 0.5 0.5 0.3 0.4 -0.3 0.5 0.1 -0.3 0.2 0.0 -0.8 -0.3 -0.2
High blood pressure (siblings) 0.6 0.9 2.4 -0.8 -0.9 1.4 -1.3 0.1 -0.2 0.9 0.9 -0.7 -0.2 -1.1 1.2 -1.3 -0.3 1.5 0.1 -0.9 0.4 -1.2
Forced vital capacity (FVC), Best measure 0.6 2.1 5.3 -1.5 -1.3 1.2 -0.2 -1.7 -1.5 1.2 1.4 -2.2 2.3 -1.1 1.4 -1.7 0.4 1.8 0.2 1.7 1.0 -1.3
Body fat percentage 0.9 3.5 11.5 -0.1 -0.5 3.4 -2.2 -0.1 0.5 3.1 2.6 -0.5 -1.9 -1.3 3.0 -0.8 -0.4 2.7 1.2 -1.9 -0.7 -2.1
Leg fat percentage (right) 1.3 4.8 14.4 -1.1 -0.9 3.8 -3.0 0.4 0.3 3.5 3.2 -0.1 -1.5 -1.5 3.4 -1.1 -0.2 3.6 1.5 -1.9 -0.7 -2.6
Arm fat-free mass (right) 0.5 2.4 5.1 0.0 -1.8 2.1 -2.3 -1.0 -1.2 2.1 1.8 -2.0 -0.0 -1.0 2.2 -1.8 0.5 2.3 0.4 -0.9 0.9 -1.2
Exposure to tobacco smoke outside home 0.9 1.2 3.2 -1.8 -1.2 0.4 0.1 -1.3 -1.3 0.2 0.5 -1.1 -1.0 -1.6 0.5 -1.5 0.4 1.8 -0.3 0.7 1.1 -1.6
Comparative body size at age 10 1.3 3.5 11.6 -2.4 -2.5 1.8 -0.7 -1.6 -1.2 1.4 1.1 -2.3 -1.1 -2.0 1.5 -3.1 -0.5 3.4 0.1 -0.1 1.5 -2.8
Number of full brothers 2.4 3.1 7.7 -0.0 1.7 2.2 -1.6 2.2 1.5 2.4 2.8 1.8 -1.2 1.8 2.3 1.1 0.6 0.7 2.4 -1.2 -2.2 0.8
Worry too long after embarrassment 0.4 0.7 5.2 0.7 0.7 0.2 -1.0 1.2 0.7 0.6 0.6 0.9 2.3 0.8 0.5 0.8 0.3 -0.1 0.7 0.4 -1.0 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 3.8 -0.1 0.7 0.6 0.3 0.3 0.3 0.4 1.3 0.5 0.2 1.0 0.9 0.5 1.9 -0.1 1.0 -0.5 -0.7 1.0
Wheeze or whistling in the chest in last year 0.5 0.9 3.3 -1.8 -1.0 1.3 -0.4 -0.4 -0.3 1.0 0.7 -0.4 -0.9 -0.9 1.0 -1.3 -0.6 1.3 -0.1 -0.9 0.5 -1.0
Number of children fathered 0.9 1.0 5.0 0.6 -1.2 -0.7 0.6 -1.4 -0.4 -0.8 -0.9 -1.2 0.3 -0.8 -0.7 -0.9 -2.2 -0.2 -1.3 0.9 1.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 3.0 1.7 0.7 0.1 -0.3 0.4 -0.0 0.1 0.2 0.3 0.6 1.0 0.4 0.5 0.8 -0.5 0.7 0.1 -0.3 1.1
Age at first live birth 0.2 0.4 1.3 0.5 -0.1 -0.9 -0.0 0.0 -1.0 -0.8 -0.8 -0.6 -0.3 0.1 -0.6 -0.2 -0.6 -1.1 -0.6 0.3 0.6 0.6
Pulse wave peak to peak time 2.3 2.7 7.7 0.7 -2.0 -1.5 0.8 -2.2 -2.8 -1.1 -1.5 -2.1 2.1 -1.4 -0.8 -1.7 -0.6 -0.4 -1.9 2.0 2.3 -0.5
Health satisfaction 0.9 1.2 5.7 2.4 0.9 -1.1 1.1 -0.0 0.5 -0.9 -0.8 0.6 1.4 1.0 -1.0 0.6 0.7 -1.8 -0.3 0.7 0.1 1.6
Shortness of breath walking on level ground 1.2 1.4 4.4 2.1 1.8 -0.5 0.9 0.8 0.8 -0.4 -0.1 1.2 -0.7 1.4 -0.3 1.7 0.9 -1.9 0.4 -0.4 -0.9 2.0
Qualifications: College or University degree 0.4 1.1 3.2 0.3 1.5 -0.4 -1.2 1.0 1.2 0.2 0.6 0.5 -0.1 1.8 0.6 1.2 1.8 -1.0 1.1 0.7 -0.9 1.8
Eye problems/disorders: None of the above 0.4 0.4 2.3 -0.6 0.3 0.0 -0.4 0.7 -0.3 0.0 -0.1 0.9 -1.5 1.1 0.1 0.5 0.9 -0.5 0.2 0.0 -0.4 1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 2.9 -0.4 0.3 -0.2 -0.4 0.5 0.3 0.2 0.3 0.5 -0.1 -0.1 -0.0 0.5 -1.7 -0.6 0.0 -0.4 -0.2 0.2
Emphysema/chronic bronchitis 0.2 0.2 0.9 -0.3 -0.5 0.5 0.7 0.0 -0.3 0.2 0.4 -0.3 -0.9 -0.7 0.3 -0.5 0.2 0.5 -0.2 -0.7 0.2 -0.7
Medication for pain relief, constipation, heartburn 1.1 1.8 5.4 -1.8 -1.6 0.5 -0.1 -1.7 -2.3 0.0 -0.4 -2.1 -0.9 -1.6 0.2 -2.1 0.3 1.7 -0.4 -0.0 1.4 -1.9
Neck or shoulder pain in last month 0.9 1.3 4.1 0.5 0.9 0.7 -1.4 1.1 0.4 1.3 0.9 2.0 1.3 1.2 0.9 1.6 0.6 -0.4 1.3 1.3 -1.4 1.0
Medication: Blood pressure 0.7 1.2 3.4 0.4 -1.6 -0.8 -0.3 -1.4 -1.5 -0.8 -0.8 -1.9 0.4 -1.2 -0.5 -1.3 -0.9 -0.3 -1.4 0.4 1.8 -0.3
Angina (self-reported) 0.5 0.7 2.0 0.9 0.3 -1.2 0.4 0.5 0.4 -0.8 -0.5 0.3 1.4 0.5 -1.0 0.7 -1.3 -1.4 -0.4 0.9 -0.0 0.9
Migraine (self-reported) 0.3 0.3 1.5 1.2 0.4 0.0 -0.9 0.9 0.7 -0.2 -0.1 1.0 -0.3 0.1 -0.1 0.9 -0.4 -0.1 0.1 -0.1 -0.6 0.1
Medication: Ibuprofen 0.6 0.7 2.3 0.6 0.3 -1.2 0.3 0.5 0.8 -0.5 0.1 0.7 1.5 0.8 -0.2 0.6 1.4 -1.1 -0.3 1.0 -0.1 1.2
Medication: Allopurinol 1.1 1.5 3.9 -1.1 -1.2 -0.2 1.0 -1.5 -0.7 -0.2 -0.6 -1.7 2.0 -1.3 -0.6 -1.7 -0.7 1.1 -1.2 1.7 1.4 -1.4
Medication: Omeprazole 3.2 3.8 8.4 0.2 2.1 1.8 -1.7 2.9 1.9 2.0 2.5 2.5 0.0 2.1 1.7 2.3 0.6 -0.2 2.8 -1.1 -2.6 1.9
Medication: Seretide 50 evohaler 1.1 1.3 6.6 -0.3 -0.6 1.4 -2.6 1.1 0.3 1.3 1.8 0.2 -1.0 -0.3 1.8 -0.4 0.3 1.3 1.0 -0.8 -0.4 -0.7
Mean time to correctly identify matches 1.0 1.8 4.2 -0.5 1.3 1.6 -0.9 1.8 2.1 1.6 1.9 1.2 -0.3 1.2 1.7 1.0 0.3 0.6 1.8 -1.6 -1.8 0.5
Heart disease (mother) 0.6 0.7 4.6 1.3 0.9 0.7 -0.0 0.3 1.6 0.2 0.1 0.7 -0.4 0.5 0.5 0.6 -0.3 -0.4 0.4 -2.2 -1.0 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 5.5 -1.5 -1.5 -0.8 1.2 -1.9 -1.2 -1.3 -1.5 -1.5 -2.1 -2.3 -1.0 -1.5 -1.1 0.5 -2.1 0.5 1.7 -2.1
Whole body fat mass 0.9 3.6 10.8 -0.2 -1.0 3.3 -2.3 -0.4 0.1 3.0 2.5 -1.1 -1.8 -1.6 3.0 -1.2 -0.6 2.9 0.9 -1.9 -0.2 -2.2
Leg fat mass (right) 1.0 4.0 11.3 -0.5 -1.3 3.4 -2.8 -0.2 -0.2 3.1 2.7 -0.9 -1.7 -1.6 3.1 -1.4 -0.4 3.2 1.1 -1.8 -0.2 -2.4
Arm predicted mass (right) 0.4 2.2 5.1 -0.0 -1.8 2.0 -2.3 -1.1 -1.2 2.0 1.6 -2.0 0.3 -1.1 2.0 -1.9 0.5 2.2 0.3 -0.7 1.0 -1.2
Pulse rate, automated reading 0.7 2.2 6.4 -2.5 -1.6 1.9 -2.2 0.2 0.0 1.9 1.4 -0.0 1.4 -1.4 1.7 -1.3 -0.1 2.5 0.4 0.2 0.2 -2.1
Alcohol intake frequency. 0.8 1.9 5.1 -1.3 0.6 2.2 -0.8 1.3 0.9 2.1 2.2 0.8 -0.8 -0.2 2.0 0.5 0.9 1.6 1.8 -1.7 -1.3 -0.6
Comparative height size at age 10 0.2 0.8 3.2 1.3 0.4 0.3 -1.1 -0.5 -0.0 0.7 1.2 -1.0 1.8 1.0 1.0 0.1 0.3 -0.2 0.6 1.3 0.1 1.5
Number of full sisters 0.5 0.6 3.4 1.5 0.5 0.4 -0.3 0.6 0.2 0.0 -0.6 0.9 -1.8 0.6 -0.0 1.0 0.4 -0.7 0.2 -1.0 -0.9 0.4
Suffer from ‘nerves’ 2.9 4.5 15.0 1.8 3.1 -0.5 0.4 2.3 1.6 -0.0 0.7 2.5 0.9 3.6 -0.1 2.9 2.9 -2.4 1.6 -0.1 -2.2 3.9
Overall health rating 1.4 3.1 6.3 0.0 1.7 1.7 -2.1 2.5 2.5 2.2 2.1 2.3 1.2 1.2 1.4 1.6 1.5 0.2 1.9 -1.3 -2.0 0.9
Chest pain or discomfort 1.6 2.3 4.0 0.4 1.8 0.7 -1.3 1.8 1.9 1.3 1.9 1.8 1.8 2.0 1.4 1.7 0.8 -0.7 2.0 -0.1 -1.8 1.8
Had major operations 0.5 0.6 1.5 -0.4 1.2 0.3 -0.9 1.1 0.6 0.5 0.6 0.7 -0.2 1.0 0.4 1.1 -0.5 -0.6 0.9 -0.8 -1.2 0.6
Age at last live birth 1.2 1.7 5.5 1.0 -0.4 -2.1 1.6 -0.5 -1.0 -2.1 -2.4 -0.7 -0.6 -0.1 -1.9 0.2 -0.7 -1.9 -1.6 0.3 0.9 0.6
Family relationship satisfaction 0.1 0.1 0.9 -0.0 0.3 -0.6 -0.2 0.3 0.9 -0.4 -0.1 -0.1 0.0 0.1 -0.2 0.0 0.1 -0.5 -0.4 0.4 0.0 0.1
Leg pain on walking 0.4 0.5 1.3 0.2 1.1 -0.0 0.5 0.5 1.1 -0.0 0.3 0.8 -0.7 1.0 0.3 0.6 1.2 -0.9 0.5 -0.9 -0.6 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 3.9 -0.3 -0.7 0.1 0.2 -0.2 -1.0 0.3 0.2 0.2 -0.6 0.4 0.3 -0.2 0.5 0.1 0.3 2.0 0.4 0.6
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.6 0.0 -1.3 -1.6 1.8 -1.7 -1.2 -1.4 -1.5 -1.9 0.3 -0.8 -1.4 -1.4 -0.4 -0.3 -1.8 1.1 1.9 -0.3
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.8 -0.1 0.6 -0.4 0.1 0.6 0.3 -0.2 0.2 0.1 -0.9 0.4 -0.4 0.3 0.3 -0.4 0.1 0.3 0.0 0.9
Medication: Aspirin 0.4 0.5 2.5 1.4 0.2 -0.4 1.3 -0.2 1.0 -0.4 -0.3 0.0 -0.2 0.2 -0.3 0.7 -1.6 -0.9 -0.6 -0.3 -0.2 0.4
Supplements: Vitamin C 0.9 1.1 3.9 -0.0 1.0 -0.0 -1.2 1.8 1.5 0.1 0.8 0.8 -1.1 0.4 0.2 1.3 -1.2 -0.8 0.7 -2.0 -1.0 0.8
Knee pain experienced in last month 0.2 0.3 1.7 0.4 -0.2 0.6 -0.3 -0.3 -0.7 0.5 0.4 0.0 0.3 -0.7 0.5 -0.4 0.7 0.5 0.1 1.3 0.4 -0.3
Hypertension (Self-reported) 1.3 3.5 8.9 -1.4 -3.0 0.3 -0.7 -2.0 -2.4 0.1 -0.3 -3.0 -0.5 -2.7 0.2 -2.9 -2.0 1.6 -1.6 0.3 2.4 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.8 -0.4 -0.2 0.6 -0.5 0.3 -0.7 0.6 0.7 -0.1 -0.9 -0.6 0.6 -0.1 -0.6 0.5 0.2 -0.3 -0.1 -0.7
Illnesses of father: Heart disease 0.4 0.6 1.6 -0.5 -0.6 -0.8 0.1 -1.0 0.1 -0.9 -0.9 -1.0 -0.9 -0.6 -0.9 -0.7 -0.6 -0.5 -1.3 -0.3 0.8 -0.5
Illnesses of siblings: Diabetes 0.1 0.2 0.6 0.6 0.3 -0.8 0.1 -0.2 0.3 -0.6 -0.6 0.5 -0.3 0.1 -0.8 0.2 0.1 -0.5 -0.2 -0.1 0.0 0.1
Smoking status: Previous 0.7 1.0 2.9 1.0 -0.3 -1.4 -0.2 -0.5 -0.6 -1.2 -1.5 -0.1 1.7 -0.0 -1.4 0.1 -0.5 -1.4 -1.1 1.6 0.6 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 3.4 0.8 -0.1 -0.2 0.3 -1.0 -0.5 -0.0 -0.1 -1.4 1.6 -0.1 0.1 -0.5 0.0 -0.4 -0.4 1.9 0.8 0.3
Whole body fat-free mass 0.2 1.1 4.8 0.6 -1.5 0.8 -1.2 -1.2 -1.2 0.8 0.7 -2.2 0.1 -0.9 1.0 -1.5 0.2 1.2 -0.3 -0.4 1.2 -0.7
Leg fat-free mass (right) 0.2 0.9 4.5 1.0 -1.3 0.7 -0.4 -1.4 -1.0 0.6 0.3 -2.1 -0.8 -0.9 0.9 -1.1 0.1 0.8 -0.5 -0.9 1.0 -0.7
Arm fat percentage (left) 0.6 2.3 9.8 0.7 -0.0 2.5 -1.1 0.0 0.9 2.1 1.7 -0.2 -3.1 -1.0 2.1 -0.1 -0.6 1.7 0.7 -2.4 -0.9 -1.6
Average weekly red wine intake 0.3 0.5 3.0 -0.9 -0.5 0.2 -0.5 -0.7 -0.3 0.7 0.2 -1.0 0.5 -0.2 0.2 -0.8 -0.3 0.7 0.0 1.7 0.6 -0.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 3.0 0.9 0.4 -1.1 0.5 0.1 -0.0 -0.9 -0.5 -0.3 -0.3 0.6 -0.8 0.5 0.0 -1.7 -0.4 0.9 0.4 1.7
Mood swings 0.3 0.5 3.9 0.3 0.5 -0.5 -0.2 0.5 0.9 -0.4 -0.4 0.7 0.4 0.7 -0.6 0.4 2.0 -0.7 -0.0 0.5 -0.1 1.2
Loneliness, isolation 1.1 1.5 5.2 0.7 1.3 0.9 -1.1 1.3 1.2 1.1 1.7 0.9 1.4 1.4 1.3 0.9 2.3 -0.0 1.4 -0.3 -1.3 1.2
Long-standing illness, disability or infirmity 1.3 2.0 7.2 0.5 1.4 1.0 -1.1 1.8 1.3 1.4 1.4 1.8 2.7 1.6 0.8 1.1 1.4 -0.4 1.7 -0.6 -1.5 1.4
Ever had bowel cancer screening 0.4 0.5 1.9 -0.2 -0.8 0.9 -1.4 0.3 0.1 0.8 0.6 -0.8 -0.2 -0.5 0.8 -0.8 0.8 1.0 -0.0 -0.4 0.2 -0.4
Diabetes diagnosed by doctor 0.5 0.8 4.3 2.1 0.7 0.2 -0.7 1.1 1.5 0.3 0.2 0.8 -0.4 0.8 0.5 1.0 -0.2 -1.0 0.5 -0.5 -1.0 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.8 0.8 0.3 -0.6 0.7 0.0 -0.0 -0.7 -0.9 -0.1 0.4 -0.4 -0.8 0.3 0.2 -0.7 -0.6 0.4 0.1 -0.0
Friendships satisfaction 0.5 0.7 1.6 0.9 -0.0 -1.1 0.6 -0.2 0.8 -1.3 -1.1 -0.6 -1.2 -0.0 -1.0 -0.1 -0.7 -1.1 -1.1 -0.4 0.5 0.5
Qualifications: nursing, teaching 0.3 0.5 2.6 -0.8 -0.5 0.7 -1.6 0.4 0.4 0.7 0.5 -0.3 -0.1 -0.6 0.7 -0.5 -0.7 1.0 0.4 -0.2 0.1 -0.9
Commuting to job workplace: Walk 2.5 2.7 5.7 -0.4 1.2 2.4 -2.3 1.4 2.2 2.2 2.2 1.1 -1.0 0.7 2.3 0.6 1.4 1.3 2.1 -1.7 -1.8 -0.2
Eye problems/disorders: Cataract 1.1 1.3 3.0 -0.6 0.0 1.7 -1.7 0.5 1.2 1.5 1.4 -0.5 -0.3 -0.4 1.6 -0.5 -0.9 1.7 1.0 -1.7 -0.6 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.2 -0.1 -1.3 -1.4 1.4 -0.6 0.0 -1.4 -1.2 -0.8 -0.9 -0.6 -1.1 -0.4 -1.0 -0.5 -1.5 0.2 1.0 -0.2
Medication for cholesterol 0.3 0.5 2.2 -1.0 -0.2 -1.1 -0.1 0.4 -1.1 -0.9 -0.9 -0.0 0.7 -0.1 -1.1 -0.2 -0.5 -0.2 -0.4 1.5 0.4 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.8 1.7 1.0 -0.3 0.1 0.5 1.1 -0.3 -0.5 1.1 -0.9 0.6 -0.3 1.4 -1.1 -1.1 -0.0 -0.1 -0.8 0.7
Back pain experienced in last month 0.9 1.3 4.2 -1.2 -0.6 1.5 -1.3 0.4 -0.4 1.5 1.2 0.4 0.0 -1.3 1.2 -0.5 -1.8 2.0 0.7 0.2 -0.3 -1.9
Mineral and other dietary supplements 0.2 0.3 0.8 0.1 0.2 -0.6 -0.4 0.1 0.4 -0.5 -0.5 -0.9 0.0 0.1 -0.6 -0.4 0.8 -0.6 -0.4 -0.4 0.6 0.7
Breast cancer (self-reported) 0.6 0.8 2.3 -0.5 0.3 1.5 -0.9 0.5 0.3 1.5 1.5 0.2 0.5 0.2 1.5 -0.2 0.8 0.9 1.2 -0.4 -0.7 -0.3
Asthma (self-reported) 0.1 0.2 1.0 -0.6 0.2 0.0 -0.3 0.9 0.2 -0.0 -0.1 0.4 -0.5 0.7 0.0 0.0 0.6 -0.6 0.4 -0.7 -0.2 1.0
Osteoporosis (self-reported) 0.4 0.5 2.3 0.5 0.6 0.5 0.3 1.0 0.6 0.2 -0.0 1.5 -1.0 0.2 0.1 1.1 0.5 0.1 0.5 -1.2 -1.1 -0.0
Osteoarthritis (self-reported) 0.5 0.7 3.3 0.1 -0.8 0.3 0.2 -1.3 -0.2 0.2 -0.4 -0.2 1.4 -1.2 -0.0 -0.6 -1.8 0.3 -0.7 0.9 0.7 -1.2
Medication: Aspirin 0.5 0.7 2.9 1.6 0.5 -0.5 1.0 0.1 1.1 -0.6 -0.5 0.4 -0.1 0.6 -0.5 1.0 -1.7 -1.2 -0.5 -0.6 -0.5 0.7
Medication: Gliclazide 0.7 0.7 1.4 1.1 0.9 0.7 -0.5 0.9 1.0 0.9 0.9 0.6 0.6 1.1 0.9 0.7 1.0 -0.4 1.2 -0.5 -0.9 1.0
Illnesses of father: None of the above (group 1) 1.9 2.4 5.3 1.1 1.6 2.0 -0.3 1.4 0.4 1.7 1.8 1.4 -2.1 1.4 2.0 1.4 1.3 0.6 2.3 -1.7 -1.8 1.1
Smoking status: Current 0.3 0.5 1.0 -0.5 0.9 0.9 0.8 0.8 0.2 0.9 1.0 0.8 -0.0 0.4 0.9 0.7 0.0 0.2 1.0 -0.1 -1.0 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.7 2.9 -0.6 -1.1 -0.2 0.6 -1.3 -0.6 -0.4 -0.3 -1.7 1.5 -0.8 -0.3 -1.1 0.2 0.5 -0.8 0.5 1.1 -0.6
Whole body water mass 0.2 1.2 4.9 0.6 -1.6 0.8 -1.2 -1.3 -1.3 0.8 0.6 -2.2 0.1 -0.9 1.0 -1.5 0.2 1.2 -0.4 -0.4 1.2 -0.7
Leg predicted mass (right) 0.2 1.0 4.5 0.9 -1.3 0.8 -0.4 -1.4 -0.9 0.6 0.4 -2.1 -0.8 -0.8 0.9 -1.1 0.2 0.9 -0.5 -1.0 1.0 -0.7
Arm fat mass (left) 0.7 2.8 7.9 0.3 -0.8 2.8 -1.7 -0.3 0.2 2.4 1.9 -0.9 -2.7 -1.4 2.5 -0.8 -0.7 2.3 0.6 -2.2 -0.3 -2.0
Number of self-reported non-cancer illnesses 0.9 1.6 5.1 -1.9 -0.3 1.8 -2.3 1.0 0.2 1.9 2.0 0.1 1.3 -0.7 1.6 -0.6 -0.8 1.6 1.0 0.1 -0.3 -0.8
Average weekly champagne plus white wine intake 3.1 4.3 9.4 0.1 -1.4 -3.0 2.5 -2.5 -1.7 -3.1 -3.0 -1.9 0.5 -1.5 -2.9 -1.3 -0.9 -1.1 -2.9 1.7 2.5 -0.9
Miserableness 1.0 1.8 3.8 1.0 -0.7 -1.8 1.2 -1.6 -1.7 -1.7 -1.8 -1.0 0.2 -1.1 -1.9 -0.4 -0.3 -0.9 -2.0 1.9 1.4 -0.3
Guilty feelings 0.7 1.0 3.1 1.2 1.5 -0.2 0.4 0.5 0.9 -0.3 -0.5 1.4 -0.4 1.4 -0.3 1.8 0.6 -1.4 0.6 -0.1 -1.2 1.7
Wears glasses or contact lenses 0.6 0.7 2.2 -0.9 -0.0 1.0 -1.3 0.4 0.3 1.1 1.5 0.3 -0.0 -0.6 1.2 0.2 0.4 1.4 0.6 -0.2 -0.7 -1.3
Ever taken oral contraceptive pill 0.9 1.0 4.8 -2.2 -0.7 -1.1 1.3 -0.6 0.0 -0.6 -0.2 -0.3 1.2 -0.5 -0.6 -0.5 -1.1 0.1 -0.9 2.0 0.9 -0.3
Hearing aid user 0.9 1.1 6.0 -0.5 -0.7 -0.9 1.4 -0.6 -0.0 -0.9 -1.4 -0.6 -0.5 -1.1 -1.3 -0.3 -2.4 -0.2 -1.6 -0.4 0.6 -1.1
Mother’s age at death 0.2 0.3 1.2 -0.4 -0.3 -0.6 -0.5 -0.3 -0.2 -0.6 -0.5 -0.3 0.6 -0.4 -0.3 0.0 -1.1 -0.1 -0.5 1.0 0.2 -0.4
Financial situation satisfaction 0.7 0.9 3.3 -0.9 -0.8 -0.3 -0.3 -0.8 -0.5 -0.4 -0.2 -1.6 -1.8 -1.0 -0.2 -1.5 -1.3 0.6 -1.1 0.3 1.2 -0.9
Tinnitus: Yes, now most or all of the time 2.0 2.3 9.4 1.8 1.4 -2.2 1.1 -0.0 1.2 -1.6 -1.4 1.2 1.1 1.4 -1.8 1.8 0.2 -3.1 -0.6 0.8 -0.3 2.2
Commuting to job workplace: Public transport 1.0 1.2 5.2 0.1 1.2 0.4 -1.3 2.3 1.2 0.6 0.9 1.5 0.2 0.8 0.4 1.6 0.0 -0.8 1.0 -0.8 -1.4 1.0
Eye problems/disorders: Glaucoma 0.5 0.5 3.0 0.5 0.7 -0.8 1.7 -0.3 0.6 -0.8 -0.4 0.4 0.8 0.5 -0.8 0.9 0.1 -1.1 -0.0 -0.2 -0.3 0.8
Medication: Blood pressure 0.5 1.0 2.4 -0.2 -1.2 0.8 0.2 -1.2 -0.6 0.3 0.2 -1.5 -0.9 -1.5 0.5 -1.4 -1.3 1.0 -0.7 -0.8 0.9 -1.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.5 -0.5 -0.3 -0.2 0.3 -0.5 -0.3 -0.1 -0.0 0.4 0.5 -0.3 0.0 0.1 0.2 0.2 0.0 0.7 -0.1 -0.5
Supplements: Fish oil (including cod liver oil) 0.8 1.1 3.4 -1.7 -0.4 1.5 -0.5 -0.0 -0.6 1.5 1.4 0.7 -0.5 -0.5 1.6 -0.1 -0.4 1.9 0.8 -0.5 -0.6 -1.3
High cholesterol (Self-reported) 1.1 2.0 3.7 -0.8 -1.9 -0.5 0.1 -1.8 -1.8 -0.2 -0.8 -1.4 1.6 -1.8 -0.5 -1.9 -1.6 0.6 -1.5 1.6 1.9 -1.6
Medication: Bendroflumethiazide 1.0 1.5 3.1 0.3 -1.3 -1.2 0.8 -1.7 -0.9 -1.2 -1.1 -1.8 -1.6 -1.0 -0.8 -1.1 -1.4 -0.7 -1.7 -0.6 1.7 -0.2
Medication: Paracetamol 0.2 0.4 3.0 0.8 -0.2 -0.4 0.3 0.1 0.2 -0.3 -0.5 0.7 -0.1 -0.0 -0.4 0.4 -1.7 -0.6 -0.6 1.1 -0.0 0.2
Medication: Lisinopril 0.4 0.5 2.4 -0.4 -0.9 -0.7 -0.5 -0.6 -0.1 -0.6 -0.3 -1.0 1.0 -0.4 -0.5 -0.9 -1.5 0.0 -0.9 0.6 1.0 -0.2
Medication: Atorvastatin 0.2 0.3 1.4 -0.2 0.2 0.0 -0.6 0.3 0.6 0.4 0.6 0.1 1.0 0.6 0.3 0.1 0.8 -0.3 0.4 1.2 0.0 0.7
Illnesses of father: High blood pressure 0.9 1.2 4.6 -1.7 -1.2 -0.5 -1.2 -0.9 -0.7 -0.2 -0.2 -1.0 2.1 -1.0 -0.1 -1.5 0.2 0.6 -1.0 1.2 1.3 -1.1
Alcohol drinker status: Never 1.3 1.5 5.1 -0.4 0.0 2.2 0.2 0.7 0.9 1.8 1.9 0.7 -1.3 0.2 2.0 -0.2 0.3 1.5 1.6 -1.5 -1.1 -0.5
Ever smoked 1.0 1.8 6.5 1.2 1.9 -0.3 -0.4 1.8 0.9 0.0 -0.5 2.1 0.9 1.6 -0.5 2.5 -0.3 -1.8 0.8 0.9 -2.0 1.3
Basal metabolic rate 0.3 1.4 4.5 0.6 -1.5 1.3 -1.4 -1.2 -1.0 1.3 1.1 -2.1 -0.3 -1.1 1.5 -1.5 0.1 1.5 -0.2 -0.7 1.0 -1.0
Leg fat percentage (left) 1.5 5.5 17.2 -1.3 -1.0 4.2 -2.9 0.2 0.3 3.8 3.2 -0.3 -1.6 -1.7 3.7 -1.2 -0.3 3.9 1.6 -2.0 -0.8 -2.9
Arm fat-free mass (left) 0.3 1.8 4.9 0.2 -1.8 1.4 -1.7 -1.2 -1.4 1.4 1.1 -2.2 0.2 -1.2 1.5 -1.9 0.2 1.9 -0.2 -0.5 1.2 -1.2
Number of operations (self-reported) 1.8 2.7 10.2 -2.2 0.4 2.2 -3.2 1.4 0.7 2.7 2.4 0.6 1.1 0.3 2.1 0.2 0.6 1.9 1.9 0.1 -1.3 -0.5
Average weekly beer plus cider intake 0.4 0.6 2.2 0.5 -0.5 -0.7 1.5 -0.9 -1.1 -0.6 -1.1 -0.2 -0.1 0.4 -0.7 -0.5 -0.7 -0.6 -0.7 1.1 0.5 0.4
Irritability 1.6 2.8 5.8 1.4 2.2 0.5 -1.3 2.1 2.4 0.7 0.9 2.4 0.1 2.3 0.6 2.3 1.4 -1.0 1.7 -1.2 -2.2 2.1
Risk taking 1.4 2.0 5.3 0.5 1.8 -0.9 0.3 2.0 1.2 -0.6 -0.3 1.7 -1.5 1.8 -0.8 2.3 0.5 -2.0 0.5 -1.1 -1.4 2.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 2.1 -0.0 0.1 -0.9 0.6 -0.4 0.7 -0.7 -0.5 -0.5 1.4 0.2 -0.6 -0.3 0.1 -0.5 -0.5 0.3 0.6 0.3
Fractured/broken bones in last 5 years 0.4 0.6 2.0 0.2 0.9 -0.6 0.3 0.9 0.8 -0.5 0.2 0.7 -0.3 1.1 -0.4 1.1 0.9 -1.2 0.1 -0.3 -0.6 1.4
Age started oral contraceptive pill 0.1 0.1 0.6 0.1 -0.7 0.3 -0.2 -0.4 -0.3 0.1 0.0 0.2 -0.8 -0.3 0.3 0.0 -0.2 0.4 -0.2 -0.0 -0.2 -0.5
Diastolic blood pressure, automated reading 0.3 1.1 3.9 -2.0 -1.7 0.2 -0.4 -0.3 -1.0 0.2 -0.2 -0.5 0.7 -1.6 -0.2 -1.4 -0.6 1.2 -0.8 -0.3 0.9 -1.9
Ever depressed for a whole week 0.5 0.6 1.3 0.0 0.8 0.3 -0.6 1.1 0.9 0.7 0.9 1.0 1.1 0.7 0.8 0.9 0.7 0.2 0.9 0.2 -1.1 0.2
Unable to work because of sickness or disability 0.4 0.5 3.4 0.1 0.2 0.2 -0.7 1.0 -0.3 0.5 0.9 0.9 1.8 0.5 0.5 0.5 0.3 -0.1 0.5 0.8 -0.5 0.6
Commuting to job workplace: Cycle 2.2 2.7 7.7 -1.1 0.9 2.5 -2.2 1.4 0.8 2.8 2.2 1.2 -0.5 1.3 2.4 0.6 0.7 1.7 2.5 -0.2 -1.9 -0.2
Myopia 0.2 0.3 1.7 -0.1 -0.2 0.7 -0.2 0.2 0.5 0.7 0.8 -0.3 0.2 -0.2 0.8 -0.4 1.3 0.8 0.2 -0.4 -0.2 -0.6
Vascular/heart problems diagnosed by doctor 1.0 2.7 7.1 0.7 2.6 -0.0 -0.0 2.0 2.0 0.1 0.6 2.7 0.1 2.4 0.1 2.4 2.3 -1.1 1.6 -0.6 -2.2 1.9
Cholesterol lowering medication 0.4 0.6 2.5 0.1 -0.4 1.5 -0.6 -0.2 0.5 1.6 0.9 -0.4 0.5 -0.3 1.4 -0.8 0.0 1.0 0.5 -0.9 -0.1 -0.8
Medication: Omeprazole (e.g. Zanprol) 3.9 4.7 10.0 0.1 2.1 2.6 -2.5 3.0 1.8 2.7 3.2 2.5 -0.2 1.8 2.5 2.2 0.2 0.4 3.2 -1.5 -2.9 1.3
Pain experienced in last month 0.4 0.6 1.5 0.1 -0.2 -0.9 1.1 -1.1 -0.3 -1.1 -1.2 -1.0 -0.9 -0.1 -0.9 -0.5 -0.1 -0.6 -1.0 -1.0 0.7 -0.0
Supplements: Calcium 0.3 0.4 3.3 0.6 -0.4 -0.1 0.3 0.1 -1.1 0.0 0.3 -0.5 0.9 0.1 0.1 -0.3 -0.1 -0.1 0.3 1.8 0.5 0.6
Basal cell carcinoma (self-reported) 1.9 2.2 5.6 0.9 2.0 0.9 -1.4 1.6 2.4 0.9 1.1 1.9 -0.4 1.7 1.1 1.6 1.1 -0.3 1.8 -1.9 -1.8 1.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 4.7 0.1 -0.7 -0.2 0.7 -0.8 -0.7 -0.5 -0.6 -0.4 0.6 -0.8 -0.5 -0.2 -2.2 -0.0 -0.6 0.1 0.4 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.9 -0.4 0.7 1.3 -1.3 0.8 1.1 0.9 0.7 1.0 -0.5 -0.1 1.1 0.7 -0.3 0.7 0.6 -1.7 -1.3 -0.8
Heart disease (siblings) 0.2 0.2 1.8 0.1 -0.6 -0.0 0.2 -0.5 0.1 -0.0 -0.3 0.0 0.0 -0.8 -0.3 -0.3 -0.7 0.3 -0.6 -0.4 0.1 -1.3
Alcohol drinker status: Previous 0.2 0.2 1.1 -0.5 -0.4 0.2 -0.8 -0.5 -0.2 0.6 -0.0 0.3 1.1 -0.4 0.4 0.2 0.2 0.2 0.3 0.8 -0.1 -0.4
Pack years of smoking 2.2 3.2 11.5 -3.4 -1.5 2.1 0.5 -0.8 -1.7 1.8 2.3 -1.5 -1.3 -2.0 2.0 -1.9 -0.5 2.9 0.7 -0.5 0.6 -2.4
Impedance of whole body 0.2 1.1 5.6 0.2 1.6 -0.4 0.3 0.5 0.8 -0.0 0.4 0.9 2.4 1.1 -0.1 1.0 0.8 -0.9 0.6 1.9 -0.7 1.2
Leg fat mass (left) 1.1 4.4 12.5 -0.6 -1.4 3.5 -2.7 -0.5 -0.3 3.2 2.7 -1.1 -1.7 -1.8 3.2 -1.6 -0.5 3.5 1.0 -1.8 -0.1 -2.7
Arm predicted mass (left) 0.5 2.4 6.1 -0.0 -2.2 1.5 -1.8 -1.5 -1.7 1.5 1.2 -2.5 -0.1 -1.5 1.7 -2.2 -0.0 2.2 -0.2 -0.5 1.4 -1.6