Best TWAS P=6.62e-10 · Best GWAS P=1.85e-19 conditioned to 2.36e-20
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | IRF5 | 0.16 | 0.08 | lasso | 4 | 0.08 | 8.2e-05 | -4.8 | -5.2 | 1.6e-07 | 0.02 | 0.08 | 0.81 | FALSE |
2 | GTEx | Adipose Visceral Omentum | OPN1SW | 0.24 | 0.15 | lasso | 3 | 0.14 | 8.3e-08 | -5.1 | -5.2 | 1.9e-07 | -0.06 | 0.10 | 0.89 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | CALU | 0.25 | 0.23 | enet | 13 | 0.20 | 1.5e-14 | -5.1 | -5.4 | 8.1e-08 | -0.03 | 0.08 | 0.92 | TRUE |
4 | GTEx | Esophagus Mucosa | OPN1SW | 0.10 | 0.04 | lasso | 5 | 0.03 | 2.4e-03 | -5.1 | -5.2 | 1.6e-07 | -0.08 | 0.09 | 0.75 | FALSE |
5 | GTEx | Esophagus Muscularis | IRF5 | 0.21 | 0.12 | lasso | 5 | 0.11 | 3.9e-07 | -4.8 | -5.2 | 1.8e-07 | 0.01 | 0.05 | 0.94 | FALSE |
6 | GTEx | Lung | OPN1SW | 0.10 | 0.09 | lasso | 4 | 0.11 | 4.7e-09 | -5.1 | -5.3 | 1.2e-07 | -0.05 | 0.09 | 0.91 | FALSE |
7 | GTEx | Nerve Tibial | IRF5 | 0.13 | 0.09 | enet | 10 | 0.07 | 1.2e-05 | -4.8 | -5.6 | 1.7e-08 | 0.01 | 0.16 | 0.81 | FALSE |
8 | GTEx | Thyroid | MKLN1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.7e-02 | 5.9 | 5.4 | 5.3e-08 | 0.01 | 0.14 | 0.08 | TRUE |
9 | GTEx | Thyroid | IRF5 | 0.14 | 0.10 | enet | 6 | 0.11 | 1.2e-08 | -4.8 | -6.2 | 6.6e-10 | 0.03 | 0.04 | 0.96 | TRUE |
10 | GTEx | Thyroid | MKLN1-AS2 | 0.28 | 0.22 | lasso | 6 | 0.25 | 8.6e-19 | 4.3 | 5.3 | 1.0e-07 | -0.01 | 1.00 | 0.00 | FALSE |
11 | GTEx | Whole Blood | IRF5 | 0.17 | 0.06 | lasso | 4 | 0.09 | 1.2e-08 | 5.2 | -5.5 | 3.4e-08 | 0.01 | 0.06 | 0.94 | FALSE |
12 | YFS | Blood | IRF5 | 0.65 | 0.75 | lasso | 4 | 0.80 | 0.0e+00 | 5.2 | 5.6 | 2.0e-08 | 0.00 | 0.05 | 0.95 | FALSE |
13 | YFS | Blood | KLHDC10 | 0.29 | 0.34 | lasso | 9 | 0.35 | 3.4e-119 | 5.3 | -5.7 | 1.6e-08 | -0.03 | 1.00 | 0.00 | TRUE |
14 | YFS | Blood | TNPO3 | 0.37 | 0.31 | enet | 32 | 0.36 | 7.4e-125 | -4.6 | 5.2 | 2.2e-07 | -0.03 | 0.53 | 0.45 | FALSE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | IRF5 | 0.29 | 0.26 | enet | 6 | 0.29 | 3.1e-17 | 5.4 | -5.2 | 2.5e-07 | 0.02 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | IRF5 | 0.17 | 0.09 | enet | 6 | 0.15 | 1.8e-07 | 5.4 | -5.2 | 1.9e-07 | 0.00 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IRF5 | 0.09 | 0.09 | blup | 30 | 0.13 | 3.1e-14 | 5.4 | -5.9 | 3.5e-09 | 0.02 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IRF5 | 0.09 | 0.10 | lasso | 3 | 0.08 | 4.6e-04 | 5.4 | -5.7 | 1.4e-08 | 0.02 | 0.02 | 0.76 | FALSE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IRF5 | 0.23 | 0.26 | lasso | 3 | 0.26 | 3.6e-27 | 5.4 | -5.2 | 1.7e-07 | 0.02 | 0.02 | 0.98 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | IRF5 | 0.22 | 0.21 | enet | 9 | 0.26 | 4.6e-25 | 5.4 | -5.4 | 8.5e-08 | 0.01 | 0.02 | 0.98 | FALSE |
21 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | IRF5 | 0.27 | 0.16 | blup | 30 | 0.22 | 9.7e-07 | 5.4 | -5.8 | 8.1e-09 | 0.01 | 0.02 | 0.97 | FALSE |