Best TWAS P=4.73e-24 · Best GWAS P=7.21e-24 conditioned to 1.78e-131
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DENND2A | 0.09 | 0.04 | enet | 16 | 0.08 | 7.1e-10 | 7.9 | -7.7 | 1.1e-14 | -0.05 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | PARP12 | 0.10 | 0.04 | lasso | 4 | 0.03 | 5.7e-03 | -7.7 | -8.4 | 6.0e-17 | -0.01 | 0.41 | 0.05 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | MRPS33 | 0.16 | 0.09 | lasso | 8 | 0.13 | 3.4e-10 | 6.0 | -5.7 | 1.6e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | NDUFB2 | 0.06 | 0.02 | lasso | 3 | 0.03 | 1.4e-03 | 7.2 | -7.9 | 2.0e-15 | -0.02 | 0.35 | 0.03 | FALSE |
| 5 | GTEx | Esophagus Mucosa | MRPS33 | 0.14 | 0.06 | lasso | 8 | 0.06 | 6.1e-05 | 6.0 | -5.2 | 2.4e-07 | -0.04 | 0.36 | 0.44 | FALSE |
| 6 | GTEx | Esophagus Muscularis | DENND2A | 0.25 | 0.19 | lasso | 4 | 0.14 | 1.3e-08 | 7.3 | 7.3 | 2.1e-13 | 0.07 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | NDUFB2-AS1 | 0.08 | 0.00 | enet | 11 | 0.00 | 3.5e-01 | 3.5 | -6.0 | 2.4e-09 | -0.01 | 0.10 | 0.15 | FALSE |
| 8 | GTEx | Nerve Tibial | MRPS33 | 0.11 | 0.05 | lasso | 5 | 0.06 | 7.1e-05 | 4.3 | -5.7 | 1.5e-08 | -0.02 | 0.55 | 0.02 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | MRPS33 | 0.10 | 0.06 | lasso | 5 | 0.03 | 1.7e-03 | 5.9 | -5.5 | 4.1e-08 | -0.04 | 0.60 | 0.04 | FALSE |
| 10 | GTEx | Testis | PARP12 | 0.21 | 0.07 | lasso | 8 | 0.05 | 2.7e-03 | 7.3 | -6.5 | 1.0e-10 | -0.59 | 0.14 | 0.50 | FALSE |
| 11 | METSIM | Adipose | MRPS33 | 0.06 | 0.01 | lasso | 13 | 0.03 | 3.2e-05 | 6.6 | -5.4 | 6.5e-08 | -0.07 | 0.86 | 0.01 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | NDUFB2 | 0.05 | 0.05 | enet | 9 | 0.04 | 7.4e-06 | 3.2 | -5.7 | 9.9e-09 | -0.08 | 0.98 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | DENND2A | 0.06 | 0.02 | lasso | 5 | 0.02 | 1.5e-03 | 7.6 | -8.8 | 2.0e-18 | -0.10 | 0.77 | 0.01 | TRUE |
| 14 | YFS | Blood | BRAF | 0.01 | 0.02 | enet | 2 | 0.01 | 1.6e-04 | 8.0 | 7.8 | 8.0e-15 | 0.01 | 0.51 | 0.44 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPS33 | 0.03 | 0.05 | blup | 28 | 0.04 | 1.7e-09 | 5.9 | -6.0 | 1.5e-09 | -0.03 | 0.13 | 0.87 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | DENND2A | 0.10 | 0.02 | blup | 69 | 0.03 | 5.7e-03 | 8.2 | 6.3 | 2.8e-10 | 0.12 | 0.02 | 0.74 | TRUE |
| 17 | The Cancer Genome Atlas | Esophageal Carcinoma | MRPS33 | 0.09 | 0.04 | blup | 28 | 0.07 | 4.0e-03 | 6.7 | -6.0 | 1.9e-09 | -0.03 | 0.00 | 0.85 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NDUFB2 | 0.07 | 0.03 | blup | 26 | 0.04 | 6.6e-05 | 5.8 | -6.3 | 2.1e-10 | 0.03 | 0.00 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PARP12 | 0.05 | 0.00 | enet | 12 | 0.02 | 5.6e-03 | 7.5 | -9.7 | 2.8e-22 | -0.38 | 0.01 | 0.40 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | MRPS33 | 0.03 | 0.02 | lasso | 3 | 0.03 | 2.6e-04 | 5.9 | -6.2 | 6.4e-10 | -0.02 | 0.03 | 0.94 | TRUE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | PARP12 | 0.02 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | 9.5 | -10.1 | 4.7e-24 | -0.88 | 0.01 | 0.88 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PARP12 | 0.06 | 0.04 | lasso | 2 | 0.04 | 1.3e-04 | 9.4 | 8.9 | 6.4e-19 | 0.93 | 0.01 | 0.96 | FALSE |
| 23 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LOC100134229 | 0.07 | 0.02 | blup | 33 | 0.03 | 1.1e-02 | -8.0 | 8.1 | 6.8e-16 | 0.05 | 0.02 | 0.46 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MRPS33 | 0.03 | 0.01 | blup | 29 | 0.01 | 3.5e-02 | 6.0 | -6.0 | 1.5e-09 | -0.03 | 0.01 | 0.39 | TRUE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | DENND2A | 0.03 | 0.01 | blup | 71 | 0.01 | 1.3e-02 | 8.2 | 7.9 | 2.4e-15 | 0.12 | 0.01 | 0.86 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPS33 | 0.06 | 0.07 | blup | 28 | 0.08 | 6.8e-08 | 5.9 | -6.0 | 2.0e-09 | -0.03 | 0.07 | 0.93 | FALSE |
| 27 | The Cancer Genome Atlas | Thyroid Carcinoma | PARP12 | 0.14 | 0.11 | enet | 10 | 0.12 | 9.4e-12 | 10.1 | -9.9 | 3.6e-23 | -0.93 | 0.00 | 1.00 | FALSE |