Best TWAS P=1.11e-22 · Best GWAS P=3.32e-77 conditioned to 8.18e-48
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SEC61A2 | 0.13 | 0.09 | lasso | 9 | 0.08 | 7.8e-10 | 7.42 | 7.6 | 2.6e-14 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | CCDC3 | 0.23 | 0.12 | enet | 11 | 0.13 | 1.8e-07 | -8.39 | 6.4 | 1.9e-10 | -0.31 | 0.68 | 0.06 | FALSE |
| 3 | GTEx | Artery Tibial | CCDC3 | 0.17 | 0.02 | lasso | 5 | 0.05 | 1.3e-04 | 7.00 | 5.8 | 8.0e-09 | -0.08 | 0.26 | 0.03 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | SEC61A2 | 0.31 | 0.26 | lasso | 3 | 0.24 | 8.4e-07 | -4.16 | 5.5 | 5.1e-08 | -0.05 | 0.86 | 0.02 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | NUDT5 | 0.13 | 0.07 | enet | 14 | 0.07 | 3.3e-06 | -8.30 | -9.8 | 1.1e-22 | -0.01 | 0.93 | 0.00 | TRUE |
| 6 | GTEx | Esophagus Muscularis | SEC61A2 | 0.18 | 0.09 | lasso | 3 | 0.15 | 1.2e-09 | -4.14 | 6.0 | 2.6e-09 | -0.04 | 0.99 | 0.00 | FALSE |
| 7 | GTEx | Nerve Tibial | SEC61A2 | 0.21 | 0.10 | enet | 25 | 0.15 | 1.6e-10 | -4.11 | 5.4 | 6.5e-08 | -0.07 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Testis | SEPHS1 | 0.25 | 0.04 | enet | 38 | 0.07 | 4.8e-04 | 1.09 | -5.9 | 3.6e-09 | 0.30 | 0.18 | 0.49 | TRUE |
| 9 | GTEx | Whole Blood | PROSER2 | 0.11 | 0.07 | enet | 12 | 0.07 | 2.5e-07 | 9.99 | 9.4 | 4.3e-21 | 0.07 | 0.00 | 1.00 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | CCDC3 | 0.15 | 0.03 | enet | 34 | 0.12 | 1.5e-15 | 3.75 | 9.1 | 6.6e-20 | -0.45 | 0.43 | 0.57 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | NUDT5 | 0.10 | 0.06 | enet | 24 | 0.07 | 8.0e-09 | -3.98 | -6.6 | 5.3e-11 | 0.06 | 1.00 | 0.00 | FALSE |
| 12 | YFS | Blood | SEC61A2 | 0.16 | 0.15 | lasso | 8 | 0.21 | 1.3e-67 | -8.79 | 6.9 | 3.9e-12 | -0.06 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SEC61A2 | 0.03 | 0.02 | blup | 59 | 0.03 | 5.2e-04 | -8.75 | 7.3 | 3.5e-13 | -0.02 | 0.00 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NUDT5 | 0.13 | -0.01 | blup | 55 | 0.01 | 1.1e-01 | -7.32 | -9.6 | 8.2e-22 | 0.00 | 0.01 | 0.48 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUDT5 | 0.03 | 0.04 | enet | 2 | 0.02 | 2.2e-03 | -8.75 | -8.5 | 1.5e-17 | 0.02 | 0.00 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CDC123 | 0.08 | 0.00 | blup | 64 | 0.03 | 4.0e-03 | 0.75 | -5.7 | 9.3e-09 | 0.06 | 0.01 | 0.19 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NUDT5 | 0.08 | 0.07 | enet | 8 | 0.07 | 8.2e-05 | -4.11 | -7.1 | 1.2e-12 | 0.06 | 0.01 | 0.98 | TRUE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC283070 | 0.04 | 0.00 | blup | 90 | 0.02 | 4.0e-03 | 4.46 | 7.4 | 1.1e-13 | -0.34 | 0.03 | 0.10 | TRUE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | NUDT5 | 0.08 | 0.05 | enet | 9 | 0.04 | 3.6e-05 | 4.32 | -5.8 | 7.0e-09 | -0.04 | 0.09 | 0.42 | FALSE |