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chr10:87,812,583-90,425,396

Best TWAS P=2.3e-12 · Best GWAS P=2.05e-19 conditioned to 2.05e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PTEN	0.07	0.00	blup	450	0.01	6.0e-02	-4.9	6.9	4.9e-12	0.55	0.02	0.95	TRUE
2	GTEx	Adipose Visceral Omentum	BMPR1A	0.12	0.08	lasso	6	0.09	2.2e-05	-5.1	5.1	2.7e-07	-0.06	0.79	0.11	FALSE
3	GTEx	Artery Tibial	RP11-359E3.4	0.07	0.04	lasso	4	0.04	6.0e-04	5.3	-5.9	4.1e-09	0.01	0.36	0.10	FALSE
4	GTEx	Brain Putamen basal ganglia	ADIRF-AS1	0.22	-0.01	lasso	6	-0.01	4.5e-01	-5.1	6.4	1.6e-10	-0.01	0.03	0.18	FALSE
5	GTEx	Breast Mammary Tissue	BMPR1A	0.09	0.06	lasso	2	0.05	1.9e-03	-5.4	5.5	3.2e-08	-0.01	0.32	0.16	FALSE
6	GTEx	Breast Mammary Tissue	PAPSS2	0.11	0.00	enet	16	0.01	8.9e-02	5.0	-6.1	1.3e-09	-0.19	0.07	0.11	FALSE
7	GTEx	Breast Mammary Tissue (Male)	BMPR1A	0.12	0.03	enet	9	0.08	6.5e-03	-5.8	6.4	1.8e-10	-0.03	0.06	0.07	FALSE
8	GTEx	Cells Transformed fibroblasts	BMPR1A	0.25	0.22	lasso	4	0.24	2.5e-18	-5.4	5.3	9.1e-08	-0.04	0.81	0.19	FALSE
9	GTEx	Esophagus Muscularis	BMPR1A	0.06	0.10	lasso	1	0.08	1.6e-05	-5.4	5.4	8.5e-08	-0.04	0.67	0.17	FALSE
10	GTEx	Heart Atrial Appendage	BMPR1A	0.12	0.09	lasso	2	0.08	2.4e-04	-5.4	5.5	3.4e-08	-0.04	0.40	0.15	FALSE
11	GTEx	Heart Left Ventricle	BMPR1A	0.12	-0.01	enet	37	0.01	7.3e-02	2.3	7.0	2.3e-12	0.05	0.04	0.06	TRUE
12	GTEx	Lung	BMPR1A	0.09	0.07	enet	15	0.06	2.1e-05	-5.8	5.1	2.8e-07	-0.06	0.59	0.38	FALSE
13	GTEx	Muscle Skeletal	BMPR1A	0.08	0.03	lasso	5	0.01	1.8e-02	-5.8	6.0	1.6e-09	-0.03	0.31	0.27	FALSE
14	GTEx	Nerve Tibial	BMPR1A	0.19	0.20	enet	13	0.18	1.2e-12	-5.4	5.2	2.2e-07	-0.04	0.81	0.19	FALSE
15	GTEx	Ovary	BMPR1A	0.36	0.11	enet	30	0.17	5.9e-05	-5.2	5.6	2.0e-08	-0.02	0.20	0.08	TRUE
16	GTEx	Pituitary	BMPR1A	0.41	0.12	lasso	9	0.14	1.9e-04	-5.4	6.4	1.8e-10	0.00	0.11	0.08	FALSE
17	METSIM	Adipose	BMPR1A	0.11	0.15	lasso	8	0.14	8.8e-21	-4.8	5.4	5.4e-08	-0.04	0.86	0.14	FALSE
18	METSIM	Adipose	GLUD1	0.05	0.03	enet	13	0.05	1.6e-07	3.9	5.7	1.3e-08	0.02	0.33	0.64	FALSE
19	METSIM	Adipose	PAPSS2	0.11	0.03	lasso	5	0.08	3.8e-12	-2.9	-5.3	1.1e-07	-0.13	0.98	0.00	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	BMPR1A	0.08	0.06	enet	10	0.09	4.0e-12	-5.4	5.6	2.4e-08	-0.02	0.79	0.21	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATAD1	0.06	0.03	enet	11	0.02	2.8e-03	-5.3	6.4	1.2e-10	0.20	0.05	0.13	FALSE
22	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BMPR1A	0.16	0.14	lasso	3	0.15	1.8e-06	-5.3	5.2	1.6e-07	-0.03	0.03	0.97	FALSE