Hub : Genes

ADIRF-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.298 0.102 0.0031 -0.009 NA -0.008 NA -0.005 0.89 NA 0.76 NA 0.55
2 GTEx Brain Putamen basal ganglia 0.219 0.090 0.0052 -0.010 NA -0.008 NA -0.005 0.67 NA 0.54 NA 0.45

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.5 2.5 0.8 -1.6
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.4 0.1
Depressed Affect (Nagel 2018) 0.7 1.6 1.7 -1.2 1.3
Depression (Nagel 2018) 0.4 0.6 1.0 -1.0 0.5
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 0.6 0.0
Neuroticism (Nagel 2018) 0.8 1.9 2.3 -1.2 1.5
Schizophrenia (2018) 0.5 1.1 2.0 0.3 1.4
Schizophrenia vs Biploar Disorder 1.5 2.0 2.6 -1.2 1.6
Worry (Nagel 2018) 0.6 1.2 1.5 -0.9 1.2
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.0 -0.1
Alzheimer’s Disease (in father) 0.3 0.3 0.6 -0.0 -0.8
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 -0.0 -0.1
Crohns Disease (2017) 0.3 0.5 1.1 1.0 -0.0
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 0.1 -0.6
Ulcerative Colitis (UC) 0.2 0.4 0.6 -0.8 -0.5
Major Depression (MDD) 0.1 0.1 0.2 -0.1 0.4
Reaction Time 0.1 0.3 0.5 0.1 0.7
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.5 0.1 -1.6
Breast Cancer 0.2 0.5 0.7 -0.4 -0.9
Ovarian Cancer 0.8 1.0 1.1 0.9 1.1
Prostate Cancer 0.6 0.8 1.0 0.8 1.0
Age at First Birth 0.3 0.5 0.9 -0.2 0.9
Bipolar Disorder (2011) 2.3 2.2 4.4 2.1 -0.2
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 0.1 -0.6
Coronary Artery Disease (CAD) 1.3 1.6 2.6 -0.8 -1.6
Crohns Disease (2012) 0.2 0.4 0.7 0.8 -0.3
Mean Putamen Volume 0.7 0.8 1.1 -1.1 -0.7
Fasting Glucose 0.9 1.1 1.5 -1.2 0.8
HbA1C 0.4 0.5 0.9 0.0 1.0
HDL Cholesterol 0.6 1.1 2.0 -0.4 1.4
LDL Cholesterol 0.3 0.4 0.6 -0.6 0.8
Lupus 0.1 0.1 0.2 -0.4 -0.1
Neuroticism (2016) 0.9 1.3 1.4 -1.1 1.2
Primary Biliary Cirrhosis 0.4 0.6 1.2 -0.1 -1.1
Rheumatoid Arthritis 0.1 0.2 0.3 0.5 0.3
Schizophrenia (2014) 0.1 0.2 0.4 0.2 0.6
Triglycerides 0.2 0.3 0.3 0.5 -0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.3 0.7 -1.1
Ulcerative Colitis 0.6 0.9 1.0 -0.9 -1.0
Blood Eosinophil Count 0.1 0.4 0.8 0.1 -0.9
Blood Platelet Count 0.2 2.1 3.3 1.8 1.0
Blood Red Count 0.1 1.0 2.0 -0.2 1.4
Blood White Count 0.3 2.1 4.0 -0.4 -2.0
Heel T-Score 0.6 4.6 5.5 1.9 -2.3
BMI 0.9 5.5 7.7 -2.8 -1.8
Height 1.1 21.8 41.0 -1.6 6.4
Waist Hip Ratio (WHR) 0.8 3.5 4.8 -1.5 2.2
Systolic Blood Pressure 0.6 3.1 6.0 0.4 -2.5
Smoking Status 0.0 0.1 0.2 0.4 -0.0
Allergy or Eczema 0.4 1.0 1.1 -1.0 -0.9
Cardiovascular Disease 0.4 1.4 1.9 -0.9 -1.4
Hypothyroidism (self reported) 0.0 0.1 0.1 0.1 -0.3
Respiratory disease 0.0 0.0 0.1 -0.0 0.3
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.6 -0.2 1.6
Lung FEV1/FVC ratio 0.1 0.5 0.5 -0.7 0.7
Lung FVC 0.1 0.3 0.7 -0.0 0.8
Neuroticism 1.0 2.4 4.6 -0.5 2.1
Chronotype (morning person) 0.4 1.0 1.7 -1.3 -0.5
Hair Pigment 0.0 0.2 0.4 -0.2 0.6
Tanning 0.0 0.4 0.5 -0.5 0.7
Hand grip strength (left) 0.3 0.8 1.4 -1.2 -0.5
Number of treatments/medications taken 1.1 2.0 3.1 -0.9 -1.8
Average weekly spirits intake 0.2 0.2 0.3 -0.5 -0.4
Sensitivity / hurt feelings 0.2 0.3 0.3 0.6 0.5
Frequency of depressed mood in last 2 weeks 1.3 1.8 3.3 -1.8 0.6
Hearing difficulty/problems: Yes 0.2 0.4 0.6 -0.4 0.7
Relative age of first facial hair 0.4 0.8 0.8 0.9 -0.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 0.9 -0.7 -1.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.5 -0.7 0.7
Ever had hysterectomy (womb removed) 1.4 1.6 2.9 0.6 1.7
Systolic blood pressure, automated reading 1.1 3.2 4.7 -1.3 -2.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.8 -0.4 1.3
Angina 2.9 3.8 6.0 1.3 -2.4
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.3 -0.5
Vitamin and mineral supplements 0.2 0.3 0.4 0.5 0.6
Supplements: Zinc 0.3 0.3 0.4 -0.5 0.6
Medication: Co-codamol 0.5 0.6 1.2 1.1 0.1
Medication: Metformin 0.4 0.5 1.0 0.2 1.0
Diabetes (father) 0.0 0.0 0.0 0.2 0.0
Diabetes (mother) 1.0 1.3 2.0 -0.8 1.4
Severe depression (siblings) 0.2 0.3 0.4 -0.4 -0.6
Pack years adult smoking proportion 0.8 1.2 2.4 0.2 1.6
Impedance of leg (right) 0.4 2.1 3.5 1.9 0.8
Leg fat-free mass (left) 0.4 1.9 2.7 -1.7 1.1
Trunk fat percentage 0.3 1.3 1.4 -1.2 -1.1
Hand grip strength (right) 0.0 0.0 0.0 -0.0 0.1
Townsend deprivation index at recruitment 1.5 2.1 3.0 1.1 -1.7
Current tobacco smoking 0.0 0.0 0.0 0.1 -0.0
Average weekly fortified wine intake 0.6 0.8 0.8 -0.8 -0.9
Maternal smoking around birth 0.4 0.6 0.9 1.0 0.5
Fed-up feelings 0.5 0.9 1.1 -0.9 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.0 -0.5
Relative age voice broke 0.6 0.9 1.6 1.3 -0.4
Taking other prescription medications 0.0 0.0 0.0 -0.0 0.2
Age when periods started (menarche) 0.4 0.9 1.5 -0.5 -1.2
Bilateral oophorectomy (both ovaries removed) 2.5 2.8 5.6 -0.4 2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.3 -0.7 -1.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.4 0.4 -0.6
Qualifications: CSEs or equivalent 0.2 0.3 0.3 0.5 0.5
Serious illness, injury or assault to yourself 0.3 0.4 0.8 -0.1 0.9
High blood pressure 1.1 3.2 6.2 -0.4 -2.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.3 -1.1 -0.9
Multivitamins +/- minerals 1.3 1.7 3.4 -1.8 0.0
Stomach or abdominal pain in last month 2.0 2.5 4.1 -2.0 -1.0
Supplements: Glucosamine 1.8 2.3 3.9 -0.9 -2.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.9 0.6 0.9
Medication: Atenolol 0.4 0.5 1.0 1.0 -0.2
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.1 -0.4
Sitting height 0.3 2.0 3.8 0.5 1.9
Chronic bronchitis/emphysema (father) 1.4 1.7 2.5 1.6 -0.9
High blood pressure (mother) 1.4 2.0 3.7 -0.4 -1.9
Body mass index (BMI) 1.1 4.6 6.1 -1.8 -2.5
Impedance of leg (left) 0.3 1.2 1.8 1.3 0.8
Leg predicted mass (left) 0.4 2.0 2.9 -1.7 1.0
Trunk fat mass 0.3 1.3 2.0 -1.4 -0.8
Waist circumference 0.7 2.6 5.2 -2.3 0.3
Number of incorrect matches in round 0.7 1.1 1.5 -0.9 1.2
Past tobacco smoking 0.0 0.0 0.1 0.2 -0.1
Alcohol usually taken with meals 0.2 0.3 0.7 -0.8 -0.1
Nervous feelings 1.3 2.4 4.8 -0.0 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.1 -0.2 0.0
Hearing difficulty/problems with background noise 0.4 0.7 1.0 -0.6 1.0
Hair/balding pattern: Pattern 2 1.3 1.7 3.2 0.4 1.8
Had menopause 1.5 1.9 2.0 -1.4 1.3
Had other major operations 0.5 0.7 0.7 -0.8 0.8
Forced vital capacity (FVC) 1.1 4.4 8.6 -0.3 2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 1.8 -0.6 -1.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.3 0.3 -0.6
Qualifications: None of the above 0.3 0.7 0.7 -0.9 -0.8
Financial difficulties in last 2 years 0.5 0.7 1.4 -1.2 -0.1
Mouth/teeth dental problems 0.9 1.3 2.4 -0.5 -1.6
Heart attack 2.5 3.1 6.3 0.1 -2.5
Allergy 0.4 0.9 1.7 1.3 0.4
Pain all over the body in last month 0.8 0.8 1.5 1.2 -0.4
Diabetes (self-reported) 1.5 2.3 2.8 -1.4 1.7
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 2.4 -1.6 -1.0
Medication: Ramipril 0.3 0.3 0.5 -0.3 -0.7
Medication: Simvastatin 0.3 0.5 0.9 0.4 -0.9
Fluid intelligence score 0.2 0.3 0.4 0.6 -0.5
Illnesses of siblings 0.1 0.2 0.3 -0.2 0.6
Neuroticism score 0.9 1.8 3.5 -0.3 1.9
Weight 0.4 2.0 3.8 -1.9 -0.4
Impedance of arm (right) 0.6 3.0 3.6 1.9 1.5
Arm fat percentage (right) 0.8 3.2 5.5 -1.0 -2.3
Trunk fat-free mass 0.4 2.2 2.9 -1.7 1.2
Hip circumference 0.3 1.3 2.5 -1.6 -0.1
Time employed in main current job 0.6 0.7 0.9 0.7 -1.0
Alcohol intake versus 10 years previously 0.3 0.5 0.5 0.7 -0.7
Father’s age at death 0.0 0.1 0.1 -0.2 -0.3
Worrier / anxious feelings 0.7 1.3 2.5 -1.6 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.0 0.1 -0.0
Falls in the last year 1.4 1.9 3.5 -0.6 1.9
Hair/balding pattern: Pattern 3 2.5 3.8 5.3 -1.5 -2.3
Number of live births 0.2 0.2 0.3 -0.3 0.6
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 9.1 -0.1 3.0
Pulse rate 0.2 0.3 0.5 -0.0 0.7
Happiness 1.5 1.9 2.6 -1.6 -1.1
Noisy workplace 1.5 1.8 2.9 -0.8 1.7
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.7 1.3 0.4
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 2.5 1.6 -0.8
Mouth/teeth dental problems: Dentures 1.4 2.3 3.9 -0.9 2.0
Asthma 0.2 0.4 0.5 -0.4 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 -0.1 0.0
Medication: Cholesterol lowering 0.2 0.4 0.4 0.6 0.7
Depression (self-reported) 1.3 1.5 2.7 -0.5 -1.7
Medication: Lansoprazole 1.5 1.8 2.7 -0.9 -1.7
Prospective memory result 0.2 0.2 0.4 -0.2 0.6
Lung cancer (father) 0.2 0.2 0.4 -0.1 0.6
Illnesses of mother 0.6 0.7 1.5 0.1 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 7.6 -0.3 2.8
Pulse wave Arterial Stiffness index 2.5 2.9 3.8 -1.4 1.9
Impedance of arm (left) 0.8 3.6 4.5 1.6 2.1
Arm fat mass (right) 0.6 2.4 2.4 -1.6 -1.5
Trunk predicted mass 0.4 2.2 2.7 -1.6 1.3
Standing height 1.1 11.0 21.5 -0.7 4.6
Length of working week for main job 0.1 0.1 0.2 0.5 -0.2
Exposure to tobacco smoke at home 0.0 0.0 0.0 0.1 0.2
Breastfed as a baby 0.5 0.6 1.2 0.2 -1.1
Tense / ‘highly strung’ 0.6 0.9 1.9 -0.1 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 0.9 -1.0 -0.7
Hair/balding pattern: Pattern 4 0.2 0.6 1.2 -0.0 -1.1
Birth weight of first child 1.4 2.6 3.1 -1.5 -1.8
Peak expiratory flow (PEF) 0.5 1.2 2.2 0.5 1.5
Pulse wave reflection index 1.1 1.4 2.6 -1.6 0.2
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.5 -0.5 -0.7
Loud music exposure frequency 1.5 1.7 3.0 -0.6 1.7
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.7 0.4 1.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.2 0.3 -0.5
Blood clot in the leg (DVT) 4.0 5.1 6.0 -2.1 2.4
Medication: Paracetamol 0.1 0.1 0.1 -0.4 0.3
Headache pain in last month 0.8 1.3 2.5 -1.6 -0.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 0.7 -0.8 0.8
Glaucoma (self-reported) 0.5 0.6 0.7 -0.7 -0.8
Gout (self-reported) 0.1 0.2 0.2 -0.5 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 -0.3 -0.8
Medication: Amlodipine 0.7 0.9 1.3 -1.1 -0.8
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.5 -0.6 -0.7
Birth weight 0.1 0.2 0.2 -0.4 0.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 0.5 0.4
High blood pressure (siblings) 0.2 0.2 0.4 -0.2 -0.6
Forced vital capacity (FVC), Best measure 1.1 4.2 8.2 -0.5 2.9
Body fat percentage 0.5 1.8 2.5 -1.1 -1.6
Leg fat percentage (right) 0.7 2.7 5.0 -0.6 -2.2
Arm fat-free mass (right) 0.7 3.5 6.2 -2.5 0.9
Exposure to tobacco smoke outside home 0.5 0.7 1.2 -1.1 -0.3
Comparative body size at age 10 0.2 0.6 0.9 0.5 -0.9
Number of full brothers 1.3 1.6 1.8 -1.3 -1.2
Worry too long after embarrassment 0.7 1.3 2.5 -0.0 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.0 -1.4 0.4
Wheeze or whistling in the chest in last year 1.1 2.0 2.0 -1.4 -1.4
Number of children fathered 1.1 1.2 1.6 0.9 1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.0 -0.5 -1.0
Age at first live birth 0.2 0.4 0.8 0.0 0.9
Pulse wave peak to peak time 1.7 2.0 2.4 1.3 -1.6
Health satisfaction 0.8 1.0 2.0 -1.4 -0.3
Shortness of breath walking on level ground 0.6 0.8 1.0 -0.8 -1.0
Qualifications: College or University degree 0.5 1.7 3.1 1.8 0.5
Eye problems/disorders: None of the above 0.0 0.1 0.1 0.1 -0.3
Mouth/teeth dental problems: Loose teeth 1.6 1.9 3.0 1.7 0.9
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.0 0.5
Medication for pain relief, constipation, heartburn 0.0 0.0 0.0 -0.1 -0.1
Neck or shoulder pain in last month 1.0 1.5 2.8 1.7 0.3
Medication: Blood pressure 1.1 1.9 3.3 0.7 -1.8
Angina (self-reported) 2.2 2.9 3.8 1.4 -1.9
Migraine (self-reported) 0.3 0.3 0.5 -0.4 0.7
Medication: Ibuprofen 0.2 0.2 0.3 0.2 -0.6
Medication: Allopurinol 0.1 0.1 0.2 -0.5 0.2
Medication: Omeprazole 0.3 0.4 0.6 0.8 -0.5
Medication: Seretide 50 evohaler 0.8 0.9 1.2 -0.8 -1.1
Mean time to correctly identify matches 0.0 0.1 0.1 -0.2 0.4
Heart disease (mother) 1.1 1.3 2.6 0.1 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 1.4 1.2 1.1
Whole body fat mass 0.4 1.7 2.2 -1.5 -1.1
Leg fat mass (right) 0.5 2.0 2.1 -1.4 -1.4
Arm predicted mass (right) 0.7 3.8 6.1 -2.5 1.2
Pulse rate, automated reading 0.6 1.8 3.4 0.5 1.8
Alcohol intake frequency. 0.6 1.4 1.8 -1.4 -1.0
Comparative height size at age 10 1.3 7.0 12.4 -1.3 3.5
Number of full sisters 0.4 0.5 1.0 1.0 0.0
Suffer from ‘nerves’ 0.7 1.1 2.1 -0.3 1.4
Overall health rating 1.1 2.3 4.6 -2.1 0.0
Chest pain or discomfort 0.1 0.2 0.4 -0.1 -0.6
Had major operations 0.6 0.7 1.2 -0.3 1.1
Age at last live birth 0.4 0.6 0.9 1.0 0.6
Family relationship satisfaction 0.0 0.0 0.1 -0.1 -0.3
Leg pain on walking 0.1 0.1 0.1 -0.1 0.4
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.8 5.7 -2.4 -1.4
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.2 0.5 -1.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.4 0.6 0.5
Medication: Aspirin 0.6 0.8 1.3 0.5 -1.1
Supplements: Vitamin C 0.4 0.5 0.9 -0.1 -1.0
Knee pain experienced in last month 1.4 2.2 2.5 -1.4 -1.6
Hypertension (Self-reported) 1.1 3.1 5.9 -0.5 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.9 5.7 0.1 -2.4
Illnesses of father: Heart disease 1.6 2.3 3.6 -1.9 1.0
Illnesses of siblings: Diabetes 0.9 1.1 2.2 1.5 0.0
Smoking status: Previous 0.1 0.1 0.1 0.4 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 2.9 1.0 1.7
Whole body fat-free mass 0.5 2.7 3.7 -1.9 1.3
Leg fat-free mass (right) 0.5 2.5 3.6 -1.9 1.2
Arm fat percentage (left) 0.6 2.3 3.4 -1.1 -1.9
Average weekly red wine intake 0.0 0.0 0.1 0.2 -0.1
Handedness (chirality/laterality): Left-handed 2.5 3.0 6.1 -0.1 -2.5
Mood swings 0.7 1.3 2.6 -1.6 -0.0
Loneliness, isolation 0.8 1.0 1.7 -0.6 -1.3
Long-standing illness, disability or infirmity 0.0 0.0 0.0 0.0 -0.2
Ever had bowel cancer screening 2.3 2.6 5.1 0.4 2.3
Diabetes diagnosed by doctor 2.0 3.3 5.3 -1.1 2.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.4 0.4 -1.2
Friendships satisfaction 1.8 2.2 3.9 0.7 -2.0
Qualifications: nursing, teaching 3.1 4.8 6.8 1.7 -2.6
Commuting to job workplace: Walk 0.7 0.7 1.3 0.4 1.2
Eye problems/disorders: Cataract 0.6 0.7 1.3 1.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.1 0.2
Medication for cholesterol 0.7 1.0 2.0 0.1 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.0 0.1 1.7
Back pain experienced in last month 0.6 0.8 1.4 0.5 -1.2
Mineral and other dietary supplements 2.1 2.9 3.8 1.9 1.4
Breast cancer (self-reported) 1.6 1.9 3.8 2.0 -0.0
Asthma (self-reported) 0.3 0.5 0.7 -0.6 -0.9
Osteoporosis (self-reported) 1.7 2.1 3.5 -0.8 1.9
Osteoarthritis (self-reported) 1.3 1.7 3.2 -1.8 0.6
Medication: Aspirin 0.4 0.5 0.9 0.9 -0.4
Medication: Gliclazide 0.6 0.7 0.7 -0.8 0.8
Illnesses of father: None of the above (group 1) 0.2 0.3 0.6 -0.2 0.8
Smoking status: Current 0.0 0.0 0.0 -0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 3.8 0.4 2.0
Whole body water mass 0.5 2.9 4.2 -2.0 1.3
Leg predicted mass (right) 0.5 2.5 3.8 -2.0 1.1
Arm fat mass (left) 0.5 2.2 2.5 -1.6 -1.3
Number of self-reported non-cancer illnesses 0.6 1.1 1.3 -1.2 -0.9
Average weekly champagne plus white wine intake 0.7 1.0 1.8 -0.3 1.4
Miserableness 1.3 2.2 3.2 -1.1 1.8
Guilty feelings 1.5 2.2 3.5 -1.9 1.0
Wears glasses or contact lenses 0.8 0.9 1.7 -1.3 -0.4
Ever taken oral contraceptive pill 0.4 0.5 0.9 1.0 0.3
Hearing aid user 0.1 0.1 0.1 -0.4 0.0
Mother’s age at death 0.3 0.4 0.6 0.4 -0.8
Financial situation satisfaction 0.7 0.8 1.3 -0.6 -1.1
Tinnitus: Yes, now most or all of the time 0.7 0.9 1.7 -0.2 1.3
Commuting to job workplace: Public transport 2.2 2.6 4.1 -1.0 2.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.1 0.1 -0.4
Medication: Blood pressure 0.6 1.2 2.1 -0.6 -1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 -0.2 -1.2
Supplements: Fish oil (including cod liver oil) 1.2 1.5 2.3 -0.9 -1.5
High cholesterol (Self-reported) 0.1 0.2 0.2 0.4 -0.4
Medication: Bendroflumethiazide 0.0 0.0 0.0 0.2 -0.2
Medication: Paracetamol 0.1 0.1 0.3 -0.5 -0.2
Medication: Lisinopril 0.4 0.6 0.6 -0.8 -0.7
Medication: Atorvastatin 1.2 1.5 2.0 1.4 0.9
Illnesses of father: High blood pressure 1.0 1.2 2.2 1.5 -0.5
Alcohol drinker status: Never 0.3 0.4 0.7 0.9 -0.3
Ever smoked 0.0 0.0 0.1 0.1 0.2
Basal metabolic rate 0.4 2.2 3.7 -1.9 0.9
Leg fat percentage (left) 0.9 3.4 6.2 -0.8 -2.5
Arm fat-free mass (left) 0.7 3.3 6.4 -2.5 0.5
Number of operations (self-reported) 0.8 1.1 2.2 -1.5 0.2
Average weekly beer plus cider intake 0.0 0.0 0.0 0.2 -0.0
Irritability 1.4 2.4 3.8 1.0 1.9
Risk taking 0.7 1.1 1.5 -0.8 1.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.4 -0.3
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.1 0.9
Age started oral contraceptive pill 0.7 0.8 1.0 -0.8 1.0
Diastolic blood pressure, automated reading 0.2 0.5 1.0 -1.0 -0.3
Ever depressed for a whole week 1.0 1.2 1.9 0.7 -1.4
Unable to work because of sickness or disability 1.5 2.0 2.6 -1.2 1.6
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.1 -0.5
Myopia 0.1 0.2 0.3 0.6 -0.0
Vascular/heart problems diagnosed by doctor 1.1 2.9 5.7 0.1 2.4
Cholesterol lowering medication 0.1 0.2 0.3 0.2 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.3 1.2 -0.1
Pain experienced in last month 1.2 2.0 3.5 0.7 1.9
Supplements: Calcium 1.7 1.9 3.7 -1.9 0.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.3 0.4
Heart attack/myocardial infarction (self-reported) 1.8 2.3 4.6 0.0 -2.1
Deep venous thrombosis (DVT) (self-reported) 4.0 5.1 5.4 -2.2 2.3
Heart disease (siblings) 0.0 0.0 0.1 -0.3 0.1
Alcohol drinker status: Previous 0.9 1.0 1.4 -1.2 0.9
Pack years of smoking 0.9 1.4 2.7 0.1 1.6
Impedance of whole body 0.5 2.7 2.8 1.7 1.6
Leg fat mass (left) 0.6 2.3 2.4 -1.5 -1.5
Arm predicted mass (left) 0.6 3.0 5.7 -2.4 0.6