Hub : Genes

GLUD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1020	0.0400	2.2e-03	-0.003	NA	-0.003	NA	-0.001	7.9e-01	NA	6.6e-01	NA	4.0e-01
2	GTEx	Cells Transformed fibroblasts	0.1410	0.0530	4.5e-04	0.008	NA	0.019	NA	0.003	7.9e-02	NA	1.4e-02	NA	1.7e-01
3	GTEx	Nerve Tibial	0.1173	0.0450	2.4e-03	0.016	NA	0.006	NA	0.006	2.3e-02	NA	1.2e-01	NA	1.1e-01
4	GTEx	Thyroid	0.0530	0.0240	8.0e-03	0.007	NA	0.000	NA	-0.003	8.1e-02	NA	3.5e-01	NA	6.0e-01
5	METSIM	Adipose	0.0541	0.0227	1.5e-04	0.027	0.026	0.046	0.037	0.034	5.9e-05	8.4e-05	1.6e-07	2.6e-06	7.5e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.1986	0.0445	4.7e-09	0.025	0.089	0.087	0.087	0.038	2.7e-04	1.4e-11	3.1e-11	2.4e-11	9.3e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	3.2	1.8	0.2	1.1	-0.8	-0.7	0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	0.1	0.2	0.5	0.9	-0.4	0.2
Depressed Affect (Nagel 2018)	1.1	2.3	3.4	-1.8	-1.7	-0.7	1.6	1.0	-1.7
Depression (Nagel 2018)	0.4	0.6	1.2	1.0	-0.2	1.0	1.1	-0.2	-0.1
Intelligence (Savage-Jansen 2018)	1.2	3.6	10.7	2.7	-0.3	3.3	1.1	-0.5	1.3
Neuroticism (Nagel 2018)	1.3	3.2	6.6	-1.2	-2.4	-0.4	0.7	2.1	-2.6
Schizophrenia (2018)	0.4	0.8	3.2	-1.2	0.1	-0.3	1.8	0.1	0.3
Schizophrenia vs Biploar Disorder	1.0	1.3	2.4	0.1	1.0	1.4	1.5	1.2	1.0
Worry (Nagel 2018)	2.4	5.1	10.4	-0.6	-3.2	-0.6	-0.4	3.0	-3.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.7	-0.1	-0.6	0.5	0.6	0.4
Alzheimer’s Disease (in father)	3.2	3.5	6.8	2.4	0.7	2.2	-0.8	-2.6	1.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.4	0.1	0.4	0.2	-0.5	0.7
Crohns Disease (2017)	0.8	1.7	7.6	0.5	-2.8	1.2	-0.6	-0.5	0.4
Irritable Bowel Disease (IBD)	0.4	1.0	2.1	1.1	-1.5	1.4	-0.3	-0.3	0.8
Ulcerative Colitis (UC)	0.4	0.7	2.2	1.1	-0.0	1.5	-0.2	-0.2	0.8
Major Depression (MDD)	0.5	0.6	2.4	-0.6	-0.3	-0.5	-0.5	1.5	-0.4
Reaction Time	1.5	2.8	12.3	-1.3	0.6	-1.2	3.5	0.1	-1.0
Verbal and Numeric Reasoning (VNR)	1.6	4.0	11.2	2.8	0.6	3.4	0.2	-1.2	1.7
Breast Cancer	0.3	0.8	1.6	-1.3	-1.0	-1.3	-0.4	0.6	0.1
Ovarian Cancer	0.5	0.7	2.0	0.9	0.1	0.5	1.4	0.8	0.8
Prostate Cancer	0.4	0.5	2.6	-0.3	1.6	0.3	0.5	0.3	0.0
Age at First Birth	0.6	0.8	3.1	0.6	1.7	0.4	0.7	-0.3	0.9
Bipolar Disorder (2011)	0.9	0.9	2.4	-0.8	-0.6	-0.8	0.6	-1.0	-1.5
Body Mass Index (BMI) (2010)	0.8	1.1	3.2	-0.0	-0.6	0.8	-1.5	-1.8	-0.2
Coronary Artery Disease (CAD)	2.2	2.6	6.7	2.6	0.3	1.6	-0.4	-2.2	1.2
Crohns Disease (2012)	1.3	2.1	10.9	0.0	-3.3	0.6	-0.5	1.1	-0.3
Mean Putamen Volume	1.1	1.2	5.0	-1.1	-2.2	-0.5	-0.3	0.3	-0.8
Fasting Glucose	0.5	0.6	1.0	0.9	-0.2	0.2	0.8	1.0	-0.9
HbA1C	1.4	1.5	6.8	2.6	-0.2	1.3	-0.3	-0.1	0.7
HDL Cholesterol	0.8	1.4	2.8	0.8	0.6	1.7	1.6	0.9	1.0
LDL Cholesterol	1.9	3.0	8.5	-1.2	-2.9	-0.1	1.2	2.1	-1.5
Lupus	0.4	0.6	1.5	0.1	1.2	1.0	-0.4	-0.6	0.5
Neuroticism (2016)	1.3	1.9	6.9	0.2	-0.2	1.2	1.7	2.6	-0.4
Primary Biliary Cirrhosis	0.2	0.4	0.9	-0.3	0.9	0.1	-0.1	-0.9	0.5
Rheumatoid Arthritis	2.9	4.0	11.0	3.3	1.3	2.5	1.1	-0.7	1.9
Schizophrenia (2014)	0.2	0.5	1.9	-0.1	0.1	0.3	1.4	-0.0	1.0
Triglycerides	0.9	1.4	2.5	-1.3	-0.7	-1.4	-1.6	0.5	-1.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	0.8	0.2	0.7	-0.9	-0.7	1.3
Ulcerative Colitis	0.6	0.8	2.6	1.6	0.9	1.0	0.4	0.1	0.6
Blood Eosinophil Count	0.7	5.4	16.6	-3.4	-0.9	-4.1	1.1	0.8	-1.3
Blood Platelet Count	0.0	0.4	1.8	0.4	-0.4	0.7	0.2	0.3	1.3
Blood Red Count	0.6	5.4	12.9	-1.0	-1.9	-2.0	-0.7	3.2	-3.6
Blood White Count	0.2	1.7	6.6	1.4	0.1	0.8	-2.6	-0.4	0.9
Heel T-Score	0.2	1.7	4.6	-0.3	-2.1	-0.8	-0.8	-1.8	-0.9
BMI	0.6	3.4	7.3	2.2	-1.2	2.7	-1.5	-1.1	1.9
Height	0.5	9.7	32.4	1.0	0.7	2.7	3.9	5.7	1.2
Waist Hip Ratio (WHR)	0.1	0.6	1.5	-0.5	-0.3	0.9	-1.0	1.2	0.4
Systolic Blood Pressure	0.5	2.5	6.0	1.0	1.0	-0.3	-2.4	-2.2	1.6
Smoking Status	0.3	0.6	2.5	-0.5	-1.6	0.3	0.7	0.6	0.3
Allergy or Eczema	0.5	1.2	3.1	1.1	-0.9	1.8	-0.3	-1.1	0.9
Cardiovascular Disease	0.9	3.0	9.1	-1.4	0.4	-1.5	-3.0	-1.8	-1.2
Hypothyroidism (self reported)	0.5	1.3	4.2	-0.5	0.9	-1.1	-2.1	-1.0	0.2
Respiratory disease	0.4	0.8	4.0	-0.4	0.2	-0.3	-0.7	2.0	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	0.3	-1.0	0.4	0.6	0.5	0.5
Lung FEV1/FVC ratio	0.3	1.7	3.0	-1.3	-0.3	-1.7	-1.6	0.2	-1.7
Lung FVC	0.6	3.0	7.8	1.0	0.6	2.0	2.2	-0.1	2.8
Neuroticism	1.3	3.2	6.3	-1.6	-2.5	-0.7	1.2	2.1	-2.0
Chronotype (morning person)	0.7	1.6	7.0	0.9	-1.1	-0.1	-2.6	-0.1	-0.8
Hair Pigment	0.1	3.1	14.7	-0.1	-3.8	1.4	0.6	0.2	-1.4
Tanning	0.1	1.0	2.5	-1.5	0.9	0.1	1.6	0.3	0.7
Hand grip strength (left)	0.2	0.4	1.3	0.5	0.6	1.1	0.2	0.3	0.7
Number of treatments/medications taken	0.9	1.6	6.2	-0.1	0.6	-0.3	0.1	-2.5	-1.8
Average weekly spirits intake	0.9	1.1	2.4	1.5	0.4	1.6	-0.4	-0.4	1.2
Sensitivity / hurt feelings	0.9	1.6	8.7	-0.1	-0.3	-0.4	-0.6	0.5	-3.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	1.1	-0.4	0.9	-0.1	-0.7	-0.6
Hearing difficulty/problems: Yes	0.8	1.2	2.4	-1.2	1.0	-0.6	1.3	-0.1	-1.5
Relative age of first facial hair	0.3	0.6	1.0	-0.6	-1.0	0.2	1.0	-0.6	-1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.3	0.1	0.0	-0.5	-0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.1	0.2	0.4	-0.7	-0.8	-0.2	-1.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.1	-0.2	-0.6	-0.2	-0.4	-0.7
Systolic blood pressure, automated reading	0.7	2.0	4.4	1.8	0.9	0.5	-2.1	-1.5	1.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.9	1.3	0.5	0.8	1.9	0.5	2.0
Angina	0.9	1.2	3.8	0.5	2.0	1.6	-0.0	-0.8	0.1
Medication for hormone replacement therapy	1.1	1.3	3.3	-0.2	-1.3	-0.1	0.8	1.4	-1.8
Vitamin and mineral supplements	0.8	1.1	3.2	-1.8	-0.6	-1.0	0.6	1.0	-0.9
Supplements: Zinc	0.5	0.5	1.4	0.4	0.9	0.5	0.7	-1.2	0.2
Medication: Co-codamol	0.2	0.2	0.8	0.4	0.6	0.1	0.3	-0.3	-0.9
Medication: Metformin	0.3	0.4	1.5	-0.4	-1.2	-0.2	0.0	0.4	0.5
Diabetes (father)	0.7	0.9	4.6	-0.5	-0.5	0.0	-0.5	-2.1	-0.2
Diabetes (mother)	1.0	1.3	2.7	1.1	-0.3	1.3	1.6	0.4	1.4
Severe depression (siblings)	1.0	1.2	2.8	0.2	0.1	1.6	0.3	-1.1	1.7
Pack years adult smoking proportion	1.1	1.7	4.9	-1.5	0.1	-1.3	0.4	2.2	-1.2
Impedance of leg (right)	0.6	3.0	8.7	-1.9	1.0	-3.0	-0.2	0.5	-2.0
Leg fat-free mass (left)	0.9	4.9	15.5	2.0	-1.1	3.9	1.3	1.6	2.2
Trunk fat percentage	0.2	0.8	1.9	1.4	-0.3	1.3	0.0	-0.2	0.9
Hand grip strength (right)	0.1	0.3	1.0	-0.1	-0.3	0.2	-0.7	1.0	-0.6
Townsend deprivation index at recruitment	0.8	1.1	2.9	-1.2	0.5	-1.0	-0.7	-1.7	0.8
Current tobacco smoking	0.2	0.4	0.8	-0.5	-0.2	-0.0	0.7	0.9	0.7
Average weekly fortified wine intake	0.4	0.4	1.6	0.1	1.3	-0.1	-0.6	-0.5	0.6
Maternal smoking around birth	1.5	2.1	5.4	-2.3	1.1	-1.8	0.9	0.6	-1.3
Fed-up feelings	1.0	1.7	4.2	-2.0	-0.5	-0.8	0.7	0.9	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.7	-0.1	0.9	0.4	-0.8	0.2
Relative age voice broke	1.2	1.8	3.1	-1.8	-1.6	-1.4	0.6	-0.1	-1.6
Taking other prescription medications	0.4	0.6	1.6	-0.6	1.2	-0.8	0.6	-0.0	-1.0
Age when periods started (menarche)	0.9	2.2	4.0	-1.1	1.9	-1.7	0.9	2.0	1.1
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	6.0	-0.4	-1.8	-0.6	0.4	1.4	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	-0.7	0.9	-1.0	0.1	-0.8	-1.2
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	7.5	-1.3	-0.6	-1.6	-0.9	0.3	-2.7
Qualifications: CSEs or equivalent	0.4	0.6	2.1	-0.4	-1.4	0.0	-0.4	-0.7	-0.8
Serious illness, injury or assault to yourself	1.0	1.2	2.7	-0.7	0.9	-0.7	1.4	1.6	-0.9
High blood pressure	0.8	2.2	6.2	0.3	0.6	0.2	-2.5	-2.5	0.6
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.6	1.2	-0.1	1.5	-0.4	-1.4	1.6
Multivitamins +/- minerals	0.4	0.5	1.5	1.1	0.4	0.4	-1.2	-0.1	-0.3
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.7	0.4	-0.9	-0.4	-0.3	-0.4
Supplements: Glucosamine	1.0	1.4	3.3	1.4	0.2	0.8	-1.8	-1.1	-1.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	5.8	-0.3	0.9	0.4	1.4	2.4	0.3
Medication: Atenolol	0.4	0.5	0.9	-0.9	0.9	-0.6	0.3	-0.8	-0.4
Medication: Levothyroxine sodium	1.0	1.7	3.5	-1.4	1.3	-1.4	-1.9	-1.0	0.3
Sitting height	0.4	2.8	11.0	-0.4	-0.2	0.0	3.3	2.1	1.1
Chronic bronchitis/emphysema (father)	0.6	0.8	1.5	-1.0	1.1	-1.2	-0.8	-0.1	-0.2
High blood pressure (mother)	0.5	0.6	1.6	0.8	0.1	0.1	-0.4	-1.2	1.3
Body mass index (BMI)	0.6	2.7	5.4	2.0	-1.7	2.3	-1.2	-0.8	1.3
Impedance of leg (left)	0.5	2.6	8.5	-1.9	0.7	-2.9	-0.3	0.3	-1.7
Leg predicted mass (left)	0.9	5.0	15.6	2.0	-1.0	4.0	1.3	1.7	2.2
Trunk fat mass	0.4	1.9	5.6	1.7	-0.7	2.4	0.1	0.5	1.5
Waist circumference	0.8	3.1	9.6	1.7	-1.7	3.1	-0.6	1.1	1.3
Number of incorrect matches in round	1.4	2.3	5.2	1.4	0.2	1.3	2.3	1.7	1.4
Past tobacco smoking	0.7	1.3	5.0	0.8	2.2	-0.5	-1.2	-0.4	0.2
Alcohol usually taken with meals	0.1	0.2	0.5	-0.1	-0.2	-0.5	0.7	0.4	-0.4
Nervous feelings	0.5	1.0	2.4	-0.1	-0.7	-0.2	0.8	1.5	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.7	-1.9	-0.4	-1.6	0.1	0.1	-1.7
Hearing difficulty/problems with background noise	0.2	0.3	1.1	-0.1	-0.6	1.1	0.6	-0.0	0.1
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	-0.8	-0.5	-0.9	0.3	0.5	-0.3
Had menopause	2.7	3.4	7.8	2.8	1.2	2.2	1.1	-0.2	2.2
Had other major operations	0.5	0.6	2.0	0.1	-0.1	1.4	1.1	-0.1	-0.4
Forced vital capacity (FVC)	0.8	3.2	6.0	0.5	-0.5	1.9	2.3	2.4	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	-0.2	0.8	-0.1	0.1	-0.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.6	-1.1	0.7	-1.3	-1.2	0.9	-0.6
Qualifications: None of the above	0.3	0.6	1.1	0.3	0.0	-0.9	-1.1	-1.0	-0.6
Financial difficulties in last 2 years	0.9	1.2	3.5	-1.0	-0.1	-1.2	-1.9	-1.0	-0.2
Mouth/teeth dental problems	0.8	1.2	3.5	1.9	-1.1	1.2	-0.3	-0.1	-0.9
Heart attack	1.5	1.9	9.4	0.7	-0.2	1.0	-0.6	-3.1	0.1
Allergy	0.9	2.1	5.3	-1.5	0.6	-2.2	-0.5	0.2	-2.3
Pain all over the body in last month	0.5	0.5	1.0	-0.7	0.6	-0.9	-0.9	0.0	1.0
Diabetes (self-reported)	0.7	1.1	3.6	0.6	-0.9	1.1	0.9	-0.0	1.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.5	0.0	0.1	0.6	-0.3	-1.6	1.1
Medication: Ramipril	0.6	0.7	2.1	-0.1	0.1	-0.4	-0.5	-1.4	1.4
Medication: Simvastatin	1.2	1.8	4.9	-1.7	0.1	-2.2	-0.8	-0.2	-1.5
Fluid intelligence score	0.8	1.6	3.9	1.9	-0.1	2.0	0.2	-1.4	0.6
Illnesses of siblings	0.5	0.6	1.5	0.2	-1.2	0.7	-0.5	0.8	-0.9
Neuroticism score	1.0	2.1	6.6	-1.1	-1.7	-0.5	0.9	1.1	-2.6
Weight	0.8	3.7	11.6	2.1	-1.5	3.4	0.1	0.9	1.8
Impedance of arm (right)	0.7	3.4	7.4	-2.4	0.9	-2.7	1.3	0.6	-2.1
Arm fat percentage (right)	0.2	1.0	2.0	1.1	-1.3	1.4	-0.9	-0.2	0.3
Trunk fat-free mass	0.8	4.8	14.1	1.4	-1.4	3.8	0.8	2.3	2.2
Hip circumference	0.5	2.3	6.7	1.5	-1.6	2.6	0.1	1.3	0.8
Time employed in main current job	1.0	1.1	2.2	1.5	-1.3	0.7	-0.3	-1.3	-0.8
Alcohol intake versus 10 years previously	0.7	1.1	3.5	0.0	-0.2	0.6	1.6	0.4	1.9
Father’s age at death	0.4	0.6	2.0	-0.9	-0.5	-0.6	0.2	0.3	-1.4
Worrier / anxious feelings	1.3	2.5	6.0	-0.3	-1.8	-1.3	-1.3	1.6	-2.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.7	0.7	1.3	0.9	0.7	-1.3	1.7
Falls in the last year	1.5	2.0	4.8	-1.8	-0.3	-1.3	1.4	-0.1	-2.2
Hair/balding pattern: Pattern 3	1.4	2.1	4.9	1.5	1.0	0.6	-2.2	-1.8	0.7
Number of live births	0.9	1.3	4.9	-1.4	-0.1	-2.2	0.1	0.8	-0.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.7	0.4	-1.0	1.8	1.7	2.2	1.8
Pulse rate	0.6	1.0	3.5	0.2	-0.6	-0.3	-1.9	1.0	-1.1
Happiness	0.3	0.4	1.4	0.2	1.2	-0.8	0.0	0.2	-0.3
Noisy workplace	1.4	1.7	3.1	-1.5	-1.7	-0.5	-1.4	1.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.5	0.1	-1.9	1.3	1.3	1.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.6	-0.1	0.6	0.1	-0.8	0.6
Mouth/teeth dental problems: Dentures	0.6	0.9	2.4	-1.5	-0.0	-1.4	1.1	-0.2	-0.5
Asthma	0.6	1.2	3.4	1.0	0.1	1.9	-0.2	0.4	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-0.6	-0.1	0.9	0.9	-1.2	1.5
Medication: Cholesterol lowering	0.8	1.2	3.4	-1.6	-0.4	-0.5	1.9	0.1	-1.1
Depression (self-reported)	1.8	2.2	5.0	1.6	1.7	0.0	-1.4	-2.2	-0.4
Medication: Lansoprazole	0.4	0.5	2.4	-0.2	-0.1	-0.6	-0.0	-0.5	-1.5
Prospective memory result	0.7	0.8	1.9	0.7	0.3	1.2	0.9	-1.4	-0.5
Lung cancer (father)	1.2	1.4	2.9	1.3	1.2	1.5	0.2	0.2	1.7
Illnesses of mother	1.1	1.4	5.1	-1.6	-0.4	-0.4	0.3	0.6	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	3.1	-0.2	-0.8	0.8	1.1	1.8	1.1
Pulse wave Arterial Stiffness index	1.1	1.2	3.1	1.8	-0.6	1.3	0.3	1.3	-0.8
Impedance of arm (left)	0.6	2.8	6.2	-1.8	1.1	-2.5	1.6	0.6	-1.8
Arm fat mass (right)	0.5	2.1	5.6	1.7	-1.4	2.4	-0.4	0.2	1.4
Trunk predicted mass	0.9	5.0	13.9	1.3	-1.4	3.7	0.9	2.5	2.3
Standing height	0.6	6.1	17.2	0.4	0.3	2.6	3.1	4.2	1.6
Length of working week for main job	0.5	0.6	2.6	0.1	0.3	-0.0	0.5	-1.6	-0.7
Exposure to tobacco smoke at home	0.4	0.5	1.5	-1.2	-0.2	-0.8	0.5	-0.4	-0.5
Breastfed as a baby	0.2	0.3	0.7	-0.1	-0.1	0.8	0.9	-0.0	0.5
Tense / ‘highly strung’	0.7	1.2	3.0	-0.3	-0.9	0.2	0.5	1.7	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.4	0.8	0.1	-1.0	-0.0	-0.5
Hair/balding pattern: Pattern 4	0.4	1.1	3.1	-0.3	-1.4	-0.2	-0.1	1.1	-1.8
Birth weight of first child	0.4	0.7	3.1	-0.7	0.2	-0.1	-0.8	-0.0	-1.8
Peak expiratory flow (PEF)	0.8	1.8	6.3	-0.7	-1.8	1.0	0.3	2.5	-0.0
Pulse wave reflection index	1.2	1.4	5.3	2.3	-1.0	1.4	-0.3	-0.2	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.6	0.6	-0.8	-0.2	-1.0	-1.1
Loud music exposure frequency	0.2	0.3	1.2	-0.3	-0.2	-0.1	-0.4	1.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.9	-0.3	-1.2	0.3	0.0	2.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	-0.9	1.2	0.1	1.0	-0.7	1.1
Blood clot in the leg (DVT)	2.3	2.9	6.9	1.9	0.2	2.6	1.7	0.5	2.0
Medication: Paracetamol	0.2	0.4	1.0	0.6	-0.4	0.7	1.0	-0.0	0.5
Headache pain in last month	0.5	0.8	1.9	0.3	0.1	0.6	-1.3	-1.0	-1.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	1.1	0.0	0.6	-0.7	1.1	1.1
Glaucoma (self-reported)	0.7	0.8	2.0	-0.0	-1.4	1.1	-0.9	0.2	0.7
Gout (self-reported)	1.1	1.5	3.6	-0.9	-1.0	-1.3	0.7	1.1	-1.9
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.8	-0.0	1.5	-0.7	-2.6	-1.1	0.1
Medication: Amlodipine	0.2	0.3	0.7	-0.3	-0.8	-0.3	0.1	-0.6	-0.8
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.4	-0.2	0.7	-0.0	-0.7	1.6	1.3
Birth weight	0.5	1.1	1.8	0.9	0.0	1.4	1.3	1.2	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.5	0.3	-0.3	-0.3	-0.9	-0.1	-1.2
High blood pressure (siblings)	1.4	2.1	7.7	0.5	0.6	0.9	0.0	-1.8	2.8
Forced vital capacity (FVC), Best measure	0.6	2.2	5.4	0.2	0.0	1.6	1.7	2.3	1.5
Body fat percentage	0.2	0.7	1.7	1.3	-0.5	1.2	-0.5	-0.2	0.6
Leg fat percentage (right)	0.2	0.8	2.3	1.0	-0.9	0.9	-1.5	-0.1	0.1
Arm fat-free mass (right)	1.0	5.2	14.3	2.2	-1.1	3.8	0.4	1.8	2.7
Exposure to tobacco smoke outside home	0.8	1.1	4.0	-0.9	0.4	-1.1	2.0	-0.7	0.2
Comparative body size at age 10	2.5	6.9	16.8	2.7	-0.7	3.8	-0.1	-1.6	4.1
Number of full brothers	0.7	0.9	2.3	-1.5	-0.3	-1.2	-0.5	-0.3	-1.2
Worry too long after embarrassment	0.3	0.5	1.0	-0.2	-0.7	0.8	0.9	1.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.3	0.4	-0.2	-0.1	0.7	0.5
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.3	-0.9	0.2	0.5	0.6	0.4
Number of children fathered	2.3	2.6	7.3	-1.5	1.2	-1.0	-1.1	1.5	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.5	1.1	-0.3	-0.3	0.3	1.9	0.1
Age at first live birth	0.6	1.1	3.5	0.9	-0.5	1.9	0.1	0.6	1.4
Pulse wave peak to peak time	0.8	1.0	2.1	-1.5	0.8	-0.9	0.0	-1.1	1.1
Health satisfaction	0.9	1.2	2.4	-0.9	0.1	-1.6	-1.5	0.5	-1.3
Shortness of breath walking on level ground	1.3	1.5	3.9	-1.4	-0.2	-2.0	-1.7	0.0	-0.4
Qualifications: College or University degree	0.1	0.3	0.6	0.1	0.5	0.7	0.8	0.1	0.4
Eye problems/disorders: None of the above	1.5	1.7	5.9	-1.1	0.7	-2.4	-0.2	0.4	-1.6
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.3	-1.5	0.9	-0.9	0.4	0.4	-0.6
Emphysema/chronic bronchitis	0.4	0.5	1.0	-1.0	0.9	-0.5	0.2	-0.5	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	3.3	-0.1	-0.0	-0.9	-1.8	-0.2	-0.4
Neck or shoulder pain in last month	1.3	1.8	2.6	-1.4	1.2	-1.2	1.4	-1.2	-1.6
Medication: Blood pressure	0.5	1.0	2.3	-0.8	-0.9	-0.7	-0.5	-1.5	-1.1
Angina (self-reported)	1.0	1.4	5.1	0.6	2.3	1.4	0.2	-0.9	0.1
Migraine (self-reported)	0.8	0.9	2.8	0.4	0.5	0.3	1.3	1.7	-0.8
Medication: Ibuprofen	0.6	0.7	2.1	-1.4	-0.5	0.1	0.8	-1.0	0.4
Medication: Allopurinol	1.5	2.0	3.9	-2.0	-0.8	-1.4	1.4	0.1	-1.9
Medication: Omeprazole	1.0	1.2	2.3	-1.1	0.4	-1.2	1.5	1.3	-0.7
Medication: Seretide 50 evohaler	2.1	2.4	4.9	-2.2	0.8	-1.8	-0.5	-1.0	-2.1
Mean time to correctly identify matches	1.0	1.9	7.5	-0.7	0.6	-1.0	2.7	-1.1	-0.9
Heart disease (mother)	0.7	0.9	3.7	0.3	0.4	-0.5	-1.9	-1.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	0.1	-0.4	0.6	1.0	0.3	1.4
Whole body fat mass	0.5	2.2	6.3	1.9	-0.9	2.5	-0.0	0.3	1.5
Leg fat mass (right)	0.6	2.2	6.5	1.9	-0.9	2.5	-0.9	0.4	1.2
Arm predicted mass (right)	1.0	5.3	14.6	2.1	-1.0	3.8	0.5	1.9	2.9
Pulse rate, automated reading	0.2	0.8	2.4	0.8	1.6	0.3	-0.7	0.2	1.0
Alcohol intake frequency.	0.7	1.5	4.4	1.5	-0.0	0.7	-2.1	-0.1	1.4
Comparative height size at age 10	0.6	3.4	6.8	1.4	-1.4	2.6	1.7	2.2	1.3
Number of full sisters	3.0	3.7	14.2	-2.0	3.8	-1.5	1.2	0.4	0.2
Suffer from ‘nerves’	0.7	1.1	2.1	0.3	-1.4	0.9	1.5	0.5	-1.1
Overall health rating	0.3	0.7	1.5	-0.2	1.2	-1.1	0.5	-0.9	-0.5
Chest pain or discomfort	0.6	0.8	1.8	-1.3	0.7	-1.3	0.1	0.6	-0.7
Had major operations	6.1	7.1	17.8	-2.9	-2.2	-3.0	-0.4	1.7	-4.2
Age at last live birth	0.3	0.4	0.6	0.4	-0.8	0.8	0.7	0.4	0.4
Family relationship satisfaction	0.5	0.6	1.8	1.1	1.3	-0.0	-0.3	-0.7	0.5
Leg pain on walking	1.2	1.5	4.2	-2.1	0.2	-2.0	-0.1	-0.6	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	6.1	0.4	0.4	-1.5	-2.5	-0.6	-1.5
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.0	-0.1	-2.0	-1.4	-1.0	-1.8	-1.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.3	0.4	0.6	0.3	0.6	-0.0
Medication: Aspirin	0.3	0.5	0.9	-0.9	-1.0	-0.5	0.1	0.4	-0.8
Supplements: Vitamin C	1.0	1.2	1.8	1.2	-0.1	1.0	1.1	-1.3	1.3
Knee pain experienced in last month	0.5	0.8	1.4	-0.5	-1.0	-1.2	-0.9	-1.1	-0.3
Hypertension (Self-reported)	0.8	2.3	7.0	-0.0	-0.1	-0.2	-2.6	-2.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	-0.6	1.2	-1.1	0.0	-0.1	-0.7
Illnesses of father: Heart disease	1.0	1.3	3.1	-0.1	-1.7	0.2	-1.8	1.3	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.4	-0.9	0.1	0.6	-0.9	0.4
Smoking status: Previous	0.7	1.1	5.4	-0.7	-2.3	0.5	0.5	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	7.0	1.4	1.2	1.8	1.0	2.6	1.4
Whole body fat-free mass	0.9	5.3	15.9	1.8	-1.3	4.0	0.9	2.2	2.3
Leg fat-free mass (right)	1.1	5.7	17.2	2.2	-1.3	4.2	1.2	1.7	2.5
Arm fat percentage (left)	0.2	0.9	2.4	1.2	-1.0	1.5	-0.7	-0.3	0.5
Average weekly red wine intake	0.5	0.8	2.2	-1.2	-0.9	-1.5	-0.4	-0.0	-0.5
Handedness (chirality/laterality): Left-handed	2.2	2.7	4.9	1.9	2.2	0.4	-1.6	-1.7	1.4
Mood swings	0.6	1.1	4.7	-0.7	-2.2	-0.1	0.7	0.5	-0.9
Loneliness, isolation	0.9	1.2	3.3	-0.1	-1.5	-0.2	0.9	-0.9	-1.8
Long-standing illness, disability or infirmity	0.7	1.0	2.4	-0.9	0.6	-1.5	-0.1	-0.8	-1.5
Ever had bowel cancer screening	1.1	1.2	3.2	0.2	1.8	0.5	1.3	1.4	0.7
Diabetes diagnosed by doctor	0.5	0.9	2.7	0.1	-0.5	0.5	1.3	0.4	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.6	0.5	-1.0	0.1	0.3	-0.6	1.3
Friendships satisfaction	0.8	0.9	1.8	-1.0	0.1	-1.1	-1.4	-0.1	-1.2
Qualifications: nursing, teaching	1.0	1.6	2.6	1.4	-1.1	1.5	-1.0	-1.6	0.7
Commuting to job workplace: Walk	1.0	1.1	4.5	0.1	0.5	0.3	0.7	2.1	1.0
Eye problems/disorders: Cataract	0.4	0.4	1.7	-0.3	-0.3	0.7	0.5	-1.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.2	0.1	1.0	-0.2	-1.5	0.2	-0.3
Medication for cholesterol	1.0	1.6	4.0	0.7	-0.0	1.6	1.4	0.7	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.9	0.2	2.0	0.6	1.3	-0.2	-0.1
Back pain experienced in last month	0.3	0.5	2.2	0.3	0.0	-0.6	0.3	-1.5	-0.5
Mineral and other dietary supplements	0.9	1.2	3.7	-0.6	-1.9	0.3	-0.2	1.5	0.7
Breast cancer (self-reported)	0.4	0.5	1.4	-0.8	-0.3	-1.2	0.3	0.1	-0.9
Asthma (self-reported)	0.6	1.2	3.3	1.2	-0.2	1.8	-0.5	0.4	1.4
Osteoporosis (self-reported)	1.3	1.6	6.5	0.7	-1.4	-0.3	-0.2	2.6	-0.4
Osteoarthritis (self-reported)	1.3	1.7	4.6	1.7	0.4	2.2	0.3	-0.6	1.4
Medication: Aspirin	0.6	0.8	1.8	-1.4	-1.0	-0.5	0.8	0.4	-0.8
Medication: Gliclazide	0.6	0.7	2.0	-1.0	-1.0	-1.4	0.5	-0.1	0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	3.1	-1.6	0.7	-1.8	1.2	0.7	-0.9
Smoking status: Current	0.3	0.4	1.0	-0.3	0.1	0.2	0.9	1.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	-0.7	0.3	0.4	1.3	1.0	1.2
Whole body water mass	0.9	5.0	15.3	1.7	-1.2	3.9	0.9	2.1	2.3
Leg predicted mass (right)	1.1	5.7	17.4	2.2	-1.3	4.2	1.2	1.7	2.4
Arm fat mass (left)	0.5	2.2	5.9	1.7	-1.5	2.4	-0.4	0.2	1.4
Number of self-reported non-cancer illnesses	0.5	0.8	1.7	-0.7	-0.2	-1.1	-1.2	-0.6	-1.3
Average weekly champagne plus white wine intake	0.7	0.9	2.1	-0.4	-1.3	0.2	1.3	1.4	0.2
Miserableness	0.9	1.5	3.9	-2.0	1.0	-0.9	0.9	0.1	-1.6
Guilty feelings	0.3	0.5	1.0	0.8	0.5	-0.2	-0.8	0.6	-1.0
Wears glasses or contact lenses	1.0	1.2	3.2	1.2	1.3	-0.2	0.4	1.8	-0.9
Ever taken oral contraceptive pill	1.2	1.3	5.6	-0.2	-1.2	0.3	2.4	0.2	-0.9
Hearing aid user	1.1	1.3	2.9	-1.0	-0.0	-1.6	0.2	-1.1	-1.7
Mother’s age at death	1.1	1.3	3.0	-0.2	1.2	0.3	0.8	-1.7	1.6
Financial situation satisfaction	0.5	0.7	1.8	-0.9	0.1	-0.9	-1.3	-0.3	-0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	0.6	0.8	0.9	-0.0	1.0	0.2
Commuting to job workplace: Public transport	2.3	2.8	9.6	-1.5	0.5	0.8	1.0	3.1	1.8
Eye problems/disorders: Glaucoma	0.9	1.0	2.9	-0.4	-1.7	1.0	0.0	1.2	1.0
Medication: Blood pressure	0.9	1.8	5.9	0.8	1.2	-0.2	-1.4	-2.4	0.8
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.9	-1.9	-1.2	-1.1	0.5	-1.4	-2.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	0.0	0.9	-0.2	0.7	-1.2	-0.1
High cholesterol (Self-reported)	0.7	1.2	3.6	-1.9	0.3	-1.4	0.4	-0.2	-1.1
Medication: Bendroflumethiazide	0.4	0.7	3.1	-0.5	0.1	-0.2	-0.7	-1.8	0.1
Medication: Paracetamol	0.3	0.5	2.0	-0.0	-1.4	0.2	0.8	-0.2	0.1
Medication: Lisinopril	0.5	0.7	1.5	1.2	0.7	0.2	0.9	-0.9	0.7
Medication: Atorvastatin	0.3	0.4	0.9	-0.2	-0.8	0.8	0.4	0.2	-0.9
Illnesses of father: High blood pressure	1.6	2.0	6.0	2.3	-0.3	2.5	-0.4	0.2	0.6
Alcohol drinker status: Never	0.9	1.0	3.5	1.0	1.9	0.2	-0.3	-1.0	0.7
Ever smoked	0.8	1.4	4.2	-1.3	-2.0	0.0	1.3	0.7	-0.1
Basal metabolic rate	0.9	4.9	15.0	1.8	-1.5	3.9	0.8	1.8	2.3
Leg fat percentage (left)	0.3	1.1	2.9	1.1	-1.2	1.0	-1.7	-0.2	0.4
Arm fat-free mass (left)	0.9	4.3	12.1	1.9	-1.4	3.5	0.2	1.8	2.2
Number of operations (self-reported)	1.4	2.1	6.1	-1.5	-1.7	-0.9	-0.2	0.9	-2.5
Average weekly beer plus cider intake	0.4	0.5	1.3	0.8	0.6	0.6	-1.2	0.6	0.4
Irritability	0.5	0.9	2.3	-1.1	-0.9	0.3	1.5	0.7	-0.5
Risk taking	0.8	1.2	5.2	-1.3	-0.4	-0.6	2.3	0.2	0.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.6	-1.6	-0.4	-1.6	-1.3	1.1	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.4	0.9	-0.6	0.5	-0.1	-0.3
Age started oral contraceptive pill	1.1	1.4	4.4	2.1	0.6	1.1	-1.2	0.2	1.1
Diastolic blood pressure, automated reading	0.7	2.2	6.1	1.3	1.8	0.5	-2.5	-1.3	0.0
Ever depressed for a whole week	0.6	0.7	2.3	-0.4	1.2	-1.5	-0.5	-0.4	-0.2
Unable to work because of sickness or disability	0.5	0.7	1.5	-0.2	1.2	-0.8	1.1	0.5	-0.7
Commuting to job workplace: Cycle	1.1	1.3	3.6	0.5	0.8	0.7	-0.1	-1.9	1.6
Myopia	0.4	0.5	1.1	0.6	1.1	0.6	0.5	0.3	1.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	6.4	-0.2	-0.5	-0.5	2.1	2.5	-0.6
Cholesterol lowering medication	0.9	1.3	3.7	-0.9	-0.1	-1.6	-1.9	-0.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.4	-0.4	1.0	-0.3	1.9	0.9	0.5
Pain experienced in last month	0.7	1.2	2.7	0.8	-0.9	1.4	-0.2	1.6	1.1
Supplements: Calcium	2.9	3.2	8.1	2.8	1.6	2.1	-0.9	-1.1	1.3
Basal cell carcinoma (self-reported)	1.0	1.1	2.9	1.7	0.1	1.6	-1.0	-0.5	-0.3
Heart attack/myocardial infarction (self-reported)	1.4	1.8	8.9	0.8	0.3	1.1	-0.2	-3.0	0.3
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	6.2	1.8	0.4	2.5	1.7	0.6	2.0
Heart disease (siblings)	0.2	0.3	1.3	-0.0	1.1	-0.5	-0.3	0.2	-0.4
Alcohol drinker status: Previous	0.4	0.4	1.5	0.9	-0.2	-0.1	-0.5	1.2	-0.3
Pack years of smoking	0.9	1.3	2.8	-1.5	0.2	-1.2	0.3	1.7	-1.0
Impedance of whole body	0.8	4.1	12.0	-2.5	1.3	-3.5	1.0	0.5	-2.0
Leg fat mass (left)	0.6	2.3	6.4	1.9	-1.1	2.5	-0.9	0.4	1.3
Arm predicted mass (left)	1.0	4.9	13.2	2.2	-1.3	3.6	0.3	1.8	2.5