Hub : Genes

GLUD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1020 0.0400 2.2e-03 -0.003 NA -0.003 NA -0.001 7.9e-01 NA 6.6e-01 NA 4.0e-01
2 GTEx Cells Transformed fibroblasts 0.1410 0.0530 4.5e-04 0.008 NA 0.019 NA 0.003 7.9e-02 NA 1.4e-02 NA 1.7e-01
3 GTEx Nerve Tibial 0.1173 0.0450 2.4e-03 0.016 NA 0.006 NA 0.006 2.3e-02 NA 1.2e-01 NA 1.1e-01
4 GTEx Thyroid 0.0530 0.0240 8.0e-03 0.007 NA 0.000 NA -0.003 8.1e-02 NA 3.5e-01 NA 6.0e-01
5 METSIM Adipose 0.0541 0.0227 1.5e-04 0.027 0.026 0.046 0.037 0.034 5.9e-05 8.4e-05 1.6e-07 2.6e-06 7.5e-06
6 ROSMAP Brain Pre-frontal Cortex 0.1986 0.0445 4.7e-09 0.025 0.089 0.087 0.087 0.038 2.7e-04 1.4e-11 3.1e-11 2.4e-11 9.3e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 0.9 3.2 1.8 0.2 1.1 -0.8 -0.7 0.0
Bipolar Disorder or Schizophrenia 0.1 0.2 0.8 0.1 0.2 0.5 0.9 -0.4 0.2
Depressed Affect (Nagel 2018) 1.1 2.3 3.4 -1.8 -1.7 -0.7 1.6 1.0 -1.7
Depression (Nagel 2018) 0.4 0.6 1.2 1.0 -0.2 1.0 1.1 -0.2 -0.1
Intelligence (Savage-Jansen 2018) 1.2 3.6 10.7 2.7 -0.3 3.3 1.1 -0.5 1.3
Neuroticism (Nagel 2018) 1.3 3.2 6.6 -1.2 -2.4 -0.4 0.7 2.1 -2.6
Schizophrenia (2018) 0.4 0.8 3.2 -1.2 0.1 -0.3 1.8 0.1 0.3
Schizophrenia vs Biploar Disorder 1.0 1.3 2.4 0.1 1.0 1.4 1.5 1.2 1.0
Worry (Nagel 2018) 2.4 5.1 10.4 -0.6 -3.2 -0.6 -0.4 3.0 -3.2
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 -0.7 -0.1 -0.6 0.5 0.6 0.4
Alzheimer’s Disease (in father) 3.2 3.5 6.8 2.4 0.7 2.2 -0.8 -2.6 1.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.5 0.4 0.1 0.4 0.2 -0.5 0.7
Crohns Disease (2017) 0.8 1.7 7.6 0.5 -2.8 1.2 -0.6 -0.5 0.4
Irritable Bowel Disease (IBD) 0.4 1.0 2.1 1.1 -1.5 1.4 -0.3 -0.3 0.8
Ulcerative Colitis (UC) 0.4 0.7 2.2 1.1 -0.0 1.5 -0.2 -0.2 0.8
Major Depression (MDD) 0.5 0.6 2.4 -0.6 -0.3 -0.5 -0.5 1.5 -0.4
Reaction Time 1.5 2.8 12.3 -1.3 0.6 -1.2 3.5 0.1 -1.0
Verbal and Numeric Reasoning (VNR) 1.6 4.0 11.2 2.8 0.6 3.4 0.2 -1.2 1.7
Breast Cancer 0.3 0.8 1.6 -1.3 -1.0 -1.3 -0.4 0.6 0.1
Ovarian Cancer 0.5 0.7 2.0 0.9 0.1 0.5 1.4 0.8 0.8
Prostate Cancer 0.4 0.5 2.6 -0.3 1.6 0.3 0.5 0.3 0.0
Age at First Birth 0.6 0.8 3.1 0.6 1.7 0.4 0.7 -0.3 0.9
Bipolar Disorder (2011) 0.9 0.9 2.4 -0.8 -0.6 -0.8 0.6 -1.0 -1.5
Body Mass Index (BMI) (2010) 0.8 1.1 3.2 -0.0 -0.6 0.8 -1.5 -1.8 -0.2
Coronary Artery Disease (CAD) 2.2 2.6 6.7 2.6 0.3 1.6 -0.4 -2.2 1.2
Crohns Disease (2012) 1.3 2.1 10.9 0.0 -3.3 0.6 -0.5 1.1 -0.3
Mean Putamen Volume 1.1 1.2 5.0 -1.1 -2.2 -0.5 -0.3 0.3 -0.8
Fasting Glucose 0.5 0.6 1.0 0.9 -0.2 0.2 0.8 1.0 -0.9
HbA1C 1.4 1.5 6.8 2.6 -0.2 1.3 -0.3 -0.1 0.7
HDL Cholesterol 0.8 1.4 2.8 0.8 0.6 1.7 1.6 0.9 1.0
LDL Cholesterol 1.9 3.0 8.5 -1.2 -2.9 -0.1 1.2 2.1 -1.5
Lupus 0.4 0.6 1.5 0.1 1.2 1.0 -0.4 -0.6 0.5
Neuroticism (2016) 1.3 1.9 6.9 0.2 -0.2 1.2 1.7 2.6 -0.4
Primary Biliary Cirrhosis 0.2 0.4 0.9 -0.3 0.9 0.1 -0.1 -0.9 0.5
Rheumatoid Arthritis 2.9 4.0 11.0 3.3 1.3 2.5 1.1 -0.7 1.9
Schizophrenia (2014) 0.2 0.5 1.9 -0.1 0.1 0.3 1.4 -0.0 1.0
Triglycerides 0.9 1.4 2.5 -1.3 -0.7 -1.4 -1.6 0.5 -1.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.6 0.8 0.2 0.7 -0.9 -0.7 1.3
Ulcerative Colitis 0.6 0.8 2.6 1.6 0.9 1.0 0.4 0.1 0.6
Blood Eosinophil Count 0.7 5.4 16.6 -3.4 -0.9 -4.1 1.1 0.8 -1.3
Blood Platelet Count 0.0 0.4 1.8 0.4 -0.4 0.7 0.2 0.3 1.3
Blood Red Count 0.6 5.4 12.9 -1.0 -1.9 -2.0 -0.7 3.2 -3.6
Blood White Count 0.2 1.7 6.6 1.4 0.1 0.8 -2.6 -0.4 0.9
Heel T-Score 0.2 1.7 4.6 -0.3 -2.1 -0.8 -0.8 -1.8 -0.9
BMI 0.6 3.4 7.3 2.2 -1.2 2.7 -1.5 -1.1 1.9
Height 0.5 9.7 32.4 1.0 0.7 2.7 3.9 5.7 1.2
Waist Hip Ratio (WHR) 0.1 0.6 1.5 -0.5 -0.3 0.9 -1.0 1.2 0.4
Systolic Blood Pressure 0.5 2.5 6.0 1.0 1.0 -0.3 -2.4 -2.2 1.6
Smoking Status 0.3 0.6 2.5 -0.5 -1.6 0.3 0.7 0.6 0.3
Allergy or Eczema 0.5 1.2 3.1 1.1 -0.9 1.8 -0.3 -1.1 0.9
Cardiovascular Disease 0.9 3.0 9.1 -1.4 0.4 -1.5 -3.0 -1.8 -1.2
Hypothyroidism (self reported) 0.5 1.3 4.2 -0.5 0.9 -1.1 -2.1 -1.0 0.2
Respiratory disease 0.4 0.8 4.0 -0.4 0.2 -0.3 -0.7 2.0 -0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 0.3 -1.0 0.4 0.6 0.5 0.5
Lung FEV1/FVC ratio 0.3 1.7 3.0 -1.3 -0.3 -1.7 -1.6 0.2 -1.7
Lung FVC 0.6 3.0 7.8 1.0 0.6 2.0 2.2 -0.1 2.8
Neuroticism 1.3 3.2 6.3 -1.6 -2.5 -0.7 1.2 2.1 -2.0
Chronotype (morning person) 0.7 1.6 7.0 0.9 -1.1 -0.1 -2.6 -0.1 -0.8
Hair Pigment 0.1 3.1 14.7 -0.1 -3.8 1.4 0.6 0.2 -1.4
Tanning 0.1 1.0 2.5 -1.5 0.9 0.1 1.6 0.3 0.7
Hand grip strength (left) 0.2 0.4 1.3 0.5 0.6 1.1 0.2 0.3 0.7
Number of treatments/medications taken 0.9 1.6 6.2 -0.1 0.6 -0.3 0.1 -2.5 -1.8
Average weekly spirits intake 0.9 1.1 2.4 1.5 0.4 1.6 -0.4 -0.4 1.2
Sensitivity / hurt feelings 0.9 1.6 8.7 -0.1 -0.3 -0.4 -0.6 0.5 -3.0
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.3 1.1 -0.4 0.9 -0.1 -0.7 -0.6
Hearing difficulty/problems: Yes 0.8 1.2 2.4 -1.2 1.0 -0.6 1.3 -0.1 -1.5
Relative age of first facial hair 0.3 0.6 1.0 -0.6 -1.0 0.2 1.0 -0.6 -1.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 0.3 0.1 0.0 -0.5 -0.4 -0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.1 0.2 0.4 -0.7 -0.8 -0.2 -1.8
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 -0.1 -0.2 -0.6 -0.2 -0.4 -0.7
Systolic blood pressure, automated reading 0.7 2.0 4.4 1.8 0.9 0.5 -2.1 -1.5 1.1
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.9 1.3 0.5 0.8 1.9 0.5 2.0
Angina 0.9 1.2 3.8 0.5 2.0 1.6 -0.0 -0.8 0.1
Medication for hormone replacement therapy 1.1 1.3 3.3 -0.2 -1.3 -0.1 0.8 1.4 -1.8
Vitamin and mineral supplements 0.8 1.1 3.2 -1.8 -0.6 -1.0 0.6 1.0 -0.9
Supplements: Zinc 0.5 0.5 1.4 0.4 0.9 0.5 0.7 -1.2 0.2
Medication: Co-codamol 0.2 0.2 0.8 0.4 0.6 0.1 0.3 -0.3 -0.9
Medication: Metformin 0.3 0.4 1.5 -0.4 -1.2 -0.2 0.0 0.4 0.5
Diabetes (father) 0.7 0.9 4.6 -0.5 -0.5 0.0 -0.5 -2.1 -0.2
Diabetes (mother) 1.0 1.3 2.7 1.1 -0.3 1.3 1.6 0.4 1.4
Severe depression (siblings) 1.0 1.2 2.8 0.2 0.1 1.6 0.3 -1.1 1.7
Pack years adult smoking proportion 1.1 1.7 4.9 -1.5 0.1 -1.3 0.4 2.2 -1.2
Impedance of leg (right) 0.6 3.0 8.7 -1.9 1.0 -3.0 -0.2 0.5 -2.0
Leg fat-free mass (left) 0.9 4.9 15.5 2.0 -1.1 3.9 1.3 1.6 2.2
Trunk fat percentage 0.2 0.8 1.9 1.4 -0.3 1.3 0.0 -0.2 0.9
Hand grip strength (right) 0.1 0.3 1.0 -0.1 -0.3 0.2 -0.7 1.0 -0.6
Townsend deprivation index at recruitment 0.8 1.1 2.9 -1.2 0.5 -1.0 -0.7 -1.7 0.8
Current tobacco smoking 0.2 0.4 0.8 -0.5 -0.2 -0.0 0.7 0.9 0.7
Average weekly fortified wine intake 0.4 0.4 1.6 0.1 1.3 -0.1 -0.6 -0.5 0.6
Maternal smoking around birth 1.5 2.1 5.4 -2.3 1.1 -1.8 0.9 0.6 -1.3
Fed-up feelings 1.0 1.7 4.2 -2.0 -0.5 -0.8 0.7 0.9 -2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.8 0.7 -0.1 0.9 0.4 -0.8 0.2
Relative age voice broke 1.2 1.8 3.1 -1.8 -1.6 -1.4 0.6 -0.1 -1.6
Taking other prescription medications 0.4 0.6 1.6 -0.6 1.2 -0.8 0.6 -0.0 -1.0
Age when periods started (menarche) 0.9 2.2 4.0 -1.1 1.9 -1.7 0.9 2.0 1.1
Bilateral oophorectomy (both ovaries removed) 1.7 1.9 6.0 -0.4 -1.8 -0.6 0.4 1.4 -2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.3 -0.7 0.9 -1.0 0.1 -0.8 -1.2
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 7.5 -1.3 -0.6 -1.6 -0.9 0.3 -2.7
Qualifications: CSEs or equivalent 0.4 0.6 2.1 -0.4 -1.4 0.0 -0.4 -0.7 -0.8
Serious illness, injury or assault to yourself 1.0 1.2 2.7 -0.7 0.9 -0.7 1.4 1.6 -0.9
High blood pressure 0.8 2.2 6.2 0.3 0.6 0.2 -2.5 -2.5 0.6
Hayfever, allergic rhinitis or eczema 0.6 1.4 2.6 1.2 -0.1 1.5 -0.4 -1.4 1.6
Multivitamins +/- minerals 0.4 0.5 1.5 1.1 0.4 0.4 -1.2 -0.1 -0.3
Stomach or abdominal pain in last month 0.2 0.3 0.7 0.7 0.4 -0.9 -0.4 -0.3 -0.4
Supplements: Glucosamine 1.0 1.4 3.3 1.4 0.2 0.8 -1.8 -1.1 -1.0
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 5.8 -0.3 0.9 0.4 1.4 2.4 0.3
Medication: Atenolol 0.4 0.5 0.9 -0.9 0.9 -0.6 0.3 -0.8 -0.4
Medication: Levothyroxine sodium 1.0 1.7 3.5 -1.4 1.3 -1.4 -1.9 -1.0 0.3
Sitting height 0.4 2.8 11.0 -0.4 -0.2 0.0 3.3 2.1 1.1
Chronic bronchitis/emphysema (father) 0.6 0.8 1.5 -1.0 1.1 -1.2 -0.8 -0.1 -0.2
High blood pressure (mother) 0.5 0.6 1.6 0.8 0.1 0.1 -0.4 -1.2 1.3
Body mass index (BMI) 0.6 2.7 5.4 2.0 -1.7 2.3 -1.2 -0.8 1.3
Impedance of leg (left) 0.5 2.6 8.5 -1.9 0.7 -2.9 -0.3 0.3 -1.7
Leg predicted mass (left) 0.9 5.0 15.6 2.0 -1.0 4.0 1.3 1.7 2.2
Trunk fat mass 0.4 1.9 5.6 1.7 -0.7 2.4 0.1 0.5 1.5
Waist circumference 0.8 3.1 9.6 1.7 -1.7 3.1 -0.6 1.1 1.3
Number of incorrect matches in round 1.4 2.3 5.2 1.4 0.2 1.3 2.3 1.7 1.4
Past tobacco smoking 0.7 1.3 5.0 0.8 2.2 -0.5 -1.2 -0.4 0.2
Alcohol usually taken with meals 0.1 0.2 0.5 -0.1 -0.2 -0.5 0.7 0.4 -0.4
Nervous feelings 0.5 1.0 2.4 -0.1 -0.7 -0.2 0.8 1.5 -1.6
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.7 -1.9 -0.4 -1.6 0.1 0.1 -1.7
Hearing difficulty/problems with background noise 0.2 0.3 1.1 -0.1 -0.6 1.1 0.6 -0.0 0.1
Hair/balding pattern: Pattern 2 0.3 0.3 0.8 -0.8 -0.5 -0.9 0.3 0.5 -0.3
Had menopause 2.7 3.4 7.8 2.8 1.2 2.2 1.1 -0.2 2.2
Had other major operations 0.5 0.6 2.0 0.1 -0.1 1.4 1.1 -0.1 -0.4
Forced vital capacity (FVC) 0.8 3.2 6.0 0.5 -0.5 1.9 2.3 2.4 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.7 -0.2 0.8 -0.1 0.1 -0.1 -0.8
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.6 -1.1 0.7 -1.3 -1.2 0.9 -0.6
Qualifications: None of the above 0.3 0.6 1.1 0.3 0.0 -0.9 -1.1 -1.0 -0.6
Financial difficulties in last 2 years 0.9 1.2 3.5 -1.0 -0.1 -1.2 -1.9 -1.0 -0.2
Mouth/teeth dental problems 0.8 1.2 3.5 1.9 -1.1 1.2 -0.3 -0.1 -0.9
Heart attack 1.5 1.9 9.4 0.7 -0.2 1.0 -0.6 -3.1 0.1
Allergy 0.9 2.1 5.3 -1.5 0.6 -2.2 -0.5 0.2 -2.3
Pain all over the body in last month 0.5 0.5 1.0 -0.7 0.6 -0.9 -0.9 0.0 1.0
Diabetes (self-reported) 0.7 1.1 3.6 0.6 -0.9 1.1 0.9 -0.0 1.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.5 0.0 0.1 0.6 -0.3 -1.6 1.1
Medication: Ramipril 0.6 0.7 2.1 -0.1 0.1 -0.4 -0.5 -1.4 1.4
Medication: Simvastatin 1.2 1.8 4.9 -1.7 0.1 -2.2 -0.8 -0.2 -1.5
Fluid intelligence score 0.8 1.6 3.9 1.9 -0.1 2.0 0.2 -1.4 0.6
Illnesses of siblings 0.5 0.6 1.5 0.2 -1.2 0.7 -0.5 0.8 -0.9
Neuroticism score 1.0 2.1 6.6 -1.1 -1.7 -0.5 0.9 1.1 -2.6
Weight 0.8 3.7 11.6 2.1 -1.5 3.4 0.1 0.9 1.8
Impedance of arm (right) 0.7 3.4 7.4 -2.4 0.9 -2.7 1.3 0.6 -2.1
Arm fat percentage (right) 0.2 1.0 2.0 1.1 -1.3 1.4 -0.9 -0.2 0.3
Trunk fat-free mass 0.8 4.8 14.1 1.4 -1.4 3.8 0.8 2.3 2.2
Hip circumference 0.5 2.3 6.7 1.5 -1.6 2.6 0.1 1.3 0.8
Time employed in main current job 1.0 1.1 2.2 1.5 -1.3 0.7 -0.3 -1.3 -0.8
Alcohol intake versus 10 years previously 0.7 1.1 3.5 0.0 -0.2 0.6 1.6 0.4 1.9
Father’s age at death 0.4 0.6 2.0 -0.9 -0.5 -0.6 0.2 0.3 -1.4
Worrier / anxious feelings 1.3 2.5 6.0 -0.3 -1.8 -1.3 -1.3 1.6 -2.4
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 2.7 0.7 1.3 0.9 0.7 -1.3 1.7
Falls in the last year 1.5 2.0 4.8 -1.8 -0.3 -1.3 1.4 -0.1 -2.2
Hair/balding pattern: Pattern 3 1.4 2.1 4.9 1.5 1.0 0.6 -2.2 -1.8 0.7
Number of live births 0.9 1.3 4.9 -1.4 -0.1 -2.2 0.1 0.8 -0.7
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 4.7 0.4 -1.0 1.8 1.7 2.2 1.8
Pulse rate 0.6 1.0 3.5 0.2 -0.6 -0.3 -1.9 1.0 -1.1
Happiness 0.3 0.4 1.4 0.2 1.2 -0.8 0.0 0.2 -0.3
Noisy workplace 1.4 1.7 3.1 -1.5 -1.7 -0.5 -1.4 1.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.5 0.1 -1.9 1.3 1.3 1.3 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.6 -0.6 -0.1 0.6 0.1 -0.8 0.6
Mouth/teeth dental problems: Dentures 0.6 0.9 2.4 -1.5 -0.0 -1.4 1.1 -0.2 -0.5
Asthma 0.6 1.2 3.4 1.0 0.1 1.9 -0.2 0.4 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.1 -0.6 -0.1 0.9 0.9 -1.2 1.5
Medication: Cholesterol lowering 0.8 1.2 3.4 -1.6 -0.4 -0.5 1.9 0.1 -1.1
Depression (self-reported) 1.8 2.2 5.0 1.6 1.7 0.0 -1.4 -2.2 -0.4
Medication: Lansoprazole 0.4 0.5 2.4 -0.2 -0.1 -0.6 -0.0 -0.5 -1.5
Prospective memory result 0.7 0.8 1.9 0.7 0.3 1.2 0.9 -1.4 -0.5
Lung cancer (father) 1.2 1.4 2.9 1.3 1.2 1.5 0.2 0.2 1.7
Illnesses of mother 1.1 1.4 5.1 -1.6 -0.4 -0.4 0.3 0.6 -2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 3.1 -0.2 -0.8 0.8 1.1 1.8 1.1
Pulse wave Arterial Stiffness index 1.1 1.2 3.1 1.8 -0.6 1.3 0.3 1.3 -0.8
Impedance of arm (left) 0.6 2.8 6.2 -1.8 1.1 -2.5 1.6 0.6 -1.8
Arm fat mass (right) 0.5 2.1 5.6 1.7 -1.4 2.4 -0.4 0.2 1.4
Trunk predicted mass 0.9 5.0 13.9 1.3 -1.4 3.7 0.9 2.5 2.3
Standing height 0.6 6.1 17.2 0.4 0.3 2.6 3.1 4.2 1.6
Length of working week for main job 0.5 0.6 2.6 0.1 0.3 -0.0 0.5 -1.6 -0.7
Exposure to tobacco smoke at home 0.4 0.5 1.5 -1.2 -0.2 -0.8 0.5 -0.4 -0.5
Breastfed as a baby 0.2 0.3 0.7 -0.1 -0.1 0.8 0.9 -0.0 0.5
Tense / ‘highly strung’ 0.7 1.2 3.0 -0.3 -0.9 0.2 0.5 1.7 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.1 0.4 0.8 0.1 -1.0 -0.0 -0.5
Hair/balding pattern: Pattern 4 0.4 1.1 3.1 -0.3 -1.4 -0.2 -0.1 1.1 -1.8
Birth weight of first child 0.4 0.7 3.1 -0.7 0.2 -0.1 -0.8 -0.0 -1.8
Peak expiratory flow (PEF) 0.8 1.8 6.3 -0.7 -1.8 1.0 0.3 2.5 -0.0
Pulse wave reflection index 1.2 1.4 5.3 2.3 -1.0 1.4 -0.3 -0.2 0.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 -0.6 0.6 -0.8 -0.2 -1.0 -1.1
Loud music exposure frequency 0.2 0.3 1.2 -0.3 -0.2 -0.1 -0.4 1.1 0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.9 -0.3 -1.2 0.3 0.0 2.2 0.0
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.5 -0.9 1.2 0.1 1.0 -0.7 1.1
Blood clot in the leg (DVT) 2.3 2.9 6.9 1.9 0.2 2.6 1.7 0.5 2.0
Medication: Paracetamol 0.2 0.4 1.0 0.6 -0.4 0.7 1.0 -0.0 0.5
Headache pain in last month 0.5 0.8 1.9 0.3 0.1 0.6 -1.3 -1.0 -1.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.2 1.1 0.0 0.6 -0.7 1.1 1.1
Glaucoma (self-reported) 0.7 0.8 2.0 -0.0 -1.4 1.1 -0.9 0.2 0.7
Gout (self-reported) 1.1 1.5 3.6 -0.9 -1.0 -1.3 0.7 1.1 -1.9
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 6.8 -0.0 1.5 -0.7 -2.6 -1.1 0.1
Medication: Amlodipine 0.2 0.3 0.7 -0.3 -0.8 -0.3 0.1 -0.6 -0.8
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.4 -0.2 0.7 -0.0 -0.7 1.6 1.3
Birth weight 0.5 1.1 1.8 0.9 0.0 1.4 1.3 1.2 0.7
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.5 0.3 -0.3 -0.3 -0.9 -0.1 -1.2
High blood pressure (siblings) 1.4 2.1 7.7 0.5 0.6 0.9 0.0 -1.8 2.8
Forced vital capacity (FVC), Best measure 0.6 2.2 5.4 0.2 0.0 1.6 1.7 2.3 1.5
Body fat percentage 0.2 0.7 1.7 1.3 -0.5 1.2 -0.5 -0.2 0.6
Leg fat percentage (right) 0.2 0.8 2.3 1.0 -0.9 0.9 -1.5 -0.1 0.1
Arm fat-free mass (right) 1.0 5.2 14.3 2.2 -1.1 3.8 0.4 1.8 2.7
Exposure to tobacco smoke outside home 0.8 1.1 4.0 -0.9 0.4 -1.1 2.0 -0.7 0.2
Comparative body size at age 10 2.5 6.9 16.8 2.7 -0.7 3.8 -0.1 -1.6 4.1
Number of full brothers 0.7 0.9 2.3 -1.5 -0.3 -1.2 -0.5 -0.3 -1.2
Worry too long after embarrassment 0.3 0.5 1.0 -0.2 -0.7 0.8 0.9 1.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.3 0.4 -0.2 -0.1 0.7 0.5
Wheeze or whistling in the chest in last year 0.2 0.3 0.8 0.3 -0.9 0.2 0.5 0.6 0.4
Number of children fathered 2.3 2.6 7.3 -1.5 1.2 -1.0 -1.1 1.5 -2.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.5 1.1 -0.3 -0.3 0.3 1.9 0.1
Age at first live birth 0.6 1.1 3.5 0.9 -0.5 1.9 0.1 0.6 1.4
Pulse wave peak to peak time 0.8 1.0 2.1 -1.5 0.8 -0.9 0.0 -1.1 1.1
Health satisfaction 0.9 1.2 2.4 -0.9 0.1 -1.6 -1.5 0.5 -1.3
Shortness of breath walking on level ground 1.3 1.5 3.9 -1.4 -0.2 -2.0 -1.7 0.0 -0.4
Qualifications: College or University degree 0.1 0.3 0.6 0.1 0.5 0.7 0.8 0.1 0.4
Eye problems/disorders: None of the above 1.5 1.7 5.9 -1.1 0.7 -2.4 -0.2 0.4 -1.6
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.3 -1.5 0.9 -0.9 0.4 0.4 -0.6
Emphysema/chronic bronchitis 0.4 0.5 1.0 -1.0 0.9 -0.5 0.2 -0.5 -0.6
Medication for pain relief, constipation, heartburn 0.4 0.7 3.3 -0.1 -0.0 -0.9 -1.8 -0.2 -0.4
Neck or shoulder pain in last month 1.3 1.8 2.6 -1.4 1.2 -1.2 1.4 -1.2 -1.6
Medication: Blood pressure 0.5 1.0 2.3 -0.8 -0.9 -0.7 -0.5 -1.5 -1.1
Angina (self-reported) 1.0 1.4 5.1 0.6 2.3 1.4 0.2 -0.9 0.1
Migraine (self-reported) 0.8 0.9 2.8 0.4 0.5 0.3 1.3 1.7 -0.8
Medication: Ibuprofen 0.6 0.7 2.1 -1.4 -0.5 0.1 0.8 -1.0 0.4
Medication: Allopurinol 1.5 2.0 3.9 -2.0 -0.8 -1.4 1.4 0.1 -1.9
Medication: Omeprazole 1.0 1.2 2.3 -1.1 0.4 -1.2 1.5 1.3 -0.7
Medication: Seretide 50 evohaler 2.1 2.4 4.9 -2.2 0.8 -1.8 -0.5 -1.0 -2.1
Mean time to correctly identify matches 1.0 1.9 7.5 -0.7 0.6 -1.0 2.7 -1.1 -0.9
Heart disease (mother) 0.7 0.9 3.7 0.3 0.4 -0.5 -1.9 -1.0 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.1 0.1 -0.4 0.6 1.0 0.3 1.4
Whole body fat mass 0.5 2.2 6.3 1.9 -0.9 2.5 -0.0 0.3 1.5
Leg fat mass (right) 0.6 2.2 6.5 1.9 -0.9 2.5 -0.9 0.4 1.2
Arm predicted mass (right) 1.0 5.3 14.6 2.1 -1.0 3.8 0.5 1.9 2.9
Pulse rate, automated reading 0.2 0.8 2.4 0.8 1.6 0.3 -0.7 0.2 1.0
Alcohol intake frequency. 0.7 1.5 4.4 1.5 -0.0 0.7 -2.1 -0.1 1.4
Comparative height size at age 10 0.6 3.4 6.8 1.4 -1.4 2.6 1.7 2.2 1.3
Number of full sisters 3.0 3.7 14.2 -2.0 3.8 -1.5 1.2 0.4 0.2
Suffer from ‘nerves’ 0.7 1.1 2.1 0.3 -1.4 0.9 1.5 0.5 -1.1
Overall health rating 0.3 0.7 1.5 -0.2 1.2 -1.1 0.5 -0.9 -0.5
Chest pain or discomfort 0.6 0.8 1.8 -1.3 0.7 -1.3 0.1 0.6 -0.7
Had major operations 6.1 7.1 17.8 -2.9 -2.2 -3.0 -0.4 1.7 -4.2
Age at last live birth 0.3 0.4 0.6 0.4 -0.8 0.8 0.7 0.4 0.4
Family relationship satisfaction 0.5 0.6 1.8 1.1 1.3 -0.0 -0.3 -0.7 0.5
Leg pain on walking 1.2 1.5 4.2 -2.1 0.2 -2.0 -0.1 -0.6 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 6.1 0.4 0.4 -1.5 -2.5 -0.6 -1.5
Commuting to job workplace: Car/motor vehicle 1.8 2.1 4.0 -0.1 -2.0 -1.4 -1.0 -1.8 -1.6
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.3 0.3 0.4 0.6 0.3 0.6 -0.0
Medication: Aspirin 0.3 0.5 0.9 -0.9 -1.0 -0.5 0.1 0.4 -0.8
Supplements: Vitamin C 1.0 1.2 1.8 1.2 -0.1 1.0 1.1 -1.3 1.3
Knee pain experienced in last month 0.5 0.8 1.4 -0.5 -1.0 -1.2 -0.9 -1.1 -0.3
Hypertension (Self-reported) 0.8 2.3 7.0 -0.0 -0.1 -0.2 -2.6 -2.6 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.4 -0.6 1.2 -1.1 0.0 -0.1 -0.7
Illnesses of father: Heart disease 1.0 1.3 3.1 -0.1 -1.7 0.2 -1.8 1.3 -0.4
Illnesses of siblings: Diabetes 0.3 0.4 0.8 0.4 -0.9 0.1 0.6 -0.9 0.4
Smoking status: Previous 0.7 1.1 5.4 -0.7 -2.3 0.5 0.5 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 7.0 1.4 1.2 1.8 1.0 2.6 1.4
Whole body fat-free mass 0.9 5.3 15.9 1.8 -1.3 4.0 0.9 2.2 2.3
Leg fat-free mass (right) 1.1 5.7 17.2 2.2 -1.3 4.2 1.2 1.7 2.5
Arm fat percentage (left) 0.2 0.9 2.4 1.2 -1.0 1.5 -0.7 -0.3 0.5
Average weekly red wine intake 0.5 0.8 2.2 -1.2 -0.9 -1.5 -0.4 -0.0 -0.5
Handedness (chirality/laterality): Left-handed 2.2 2.7 4.9 1.9 2.2 0.4 -1.6 -1.7 1.4
Mood swings 0.6 1.1 4.7 -0.7 -2.2 -0.1 0.7 0.5 -0.9
Loneliness, isolation 0.9 1.2 3.3 -0.1 -1.5 -0.2 0.9 -0.9 -1.8
Long-standing illness, disability or infirmity 0.7 1.0 2.4 -0.9 0.6 -1.5 -0.1 -0.8 -1.5
Ever had bowel cancer screening 1.1 1.2 3.2 0.2 1.8 0.5 1.3 1.4 0.7
Diabetes diagnosed by doctor 0.5 0.9 2.7 0.1 -0.5 0.5 1.3 0.4 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.6 0.5 -1.0 0.1 0.3 -0.6 1.3
Friendships satisfaction 0.8 0.9 1.8 -1.0 0.1 -1.1 -1.4 -0.1 -1.2
Qualifications: nursing, teaching 1.0 1.6 2.6 1.4 -1.1 1.5 -1.0 -1.6 0.7
Commuting to job workplace: Walk 1.0 1.1 4.5 0.1 0.5 0.3 0.7 2.1 1.0
Eye problems/disorders: Cataract 0.4 0.4 1.7 -0.3 -0.3 0.7 0.5 -1.3 0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.2 0.1 1.0 -0.2 -1.5 0.2 -0.3
Medication for cholesterol 1.0 1.6 4.0 0.7 -0.0 1.6 1.4 0.7 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 3.9 0.2 2.0 0.6 1.3 -0.2 -0.1
Back pain experienced in last month 0.3 0.5 2.2 0.3 0.0 -0.6 0.3 -1.5 -0.5
Mineral and other dietary supplements 0.9 1.2 3.7 -0.6 -1.9 0.3 -0.2 1.5 0.7
Breast cancer (self-reported) 0.4 0.5 1.4 -0.8 -0.3 -1.2 0.3 0.1 -0.9
Asthma (self-reported) 0.6 1.2 3.3 1.2 -0.2 1.8 -0.5 0.4 1.4
Osteoporosis (self-reported) 1.3 1.6 6.5 0.7 -1.4 -0.3 -0.2 2.6 -0.4
Osteoarthritis (self-reported) 1.3 1.7 4.6 1.7 0.4 2.2 0.3 -0.6 1.4
Medication: Aspirin 0.6 0.8 1.8 -1.4 -1.0 -0.5 0.8 0.4 -0.8
Medication: Gliclazide 0.6 0.7 2.0 -1.0 -1.0 -1.4 0.5 -0.1 0.2
Illnesses of father: None of the above (group 1) 1.2 1.5 3.1 -1.6 0.7 -1.8 1.2 0.7 -0.9
Smoking status: Current 0.3 0.4 1.0 -0.3 0.1 0.2 0.9 1.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.7 -0.7 0.3 0.4 1.3 1.0 1.2
Whole body water mass 0.9 5.0 15.3 1.7 -1.2 3.9 0.9 2.1 2.3
Leg predicted mass (right) 1.1 5.7 17.4 2.2 -1.3 4.2 1.2 1.7 2.4
Arm fat mass (left) 0.5 2.2 5.9 1.7 -1.5 2.4 -0.4 0.2 1.4
Number of self-reported non-cancer illnesses 0.5 0.8 1.7 -0.7 -0.2 -1.1 -1.2 -0.6 -1.3
Average weekly champagne plus white wine intake 0.7 0.9 2.1 -0.4 -1.3 0.2 1.3 1.4 0.2
Miserableness 0.9 1.5 3.9 -2.0 1.0 -0.9 0.9 0.1 -1.6
Guilty feelings 0.3 0.5 1.0 0.8 0.5 -0.2 -0.8 0.6 -1.0
Wears glasses or contact lenses 1.0 1.2 3.2 1.2 1.3 -0.2 0.4 1.8 -0.9
Ever taken oral contraceptive pill 1.2 1.3 5.6 -0.2 -1.2 0.3 2.4 0.2 -0.9
Hearing aid user 1.1 1.3 2.9 -1.0 -0.0 -1.6 0.2 -1.1 -1.7
Mother’s age at death 1.1 1.3 3.0 -0.2 1.2 0.3 0.8 -1.7 1.6
Financial situation satisfaction 0.5 0.7 1.8 -0.9 0.1 -0.9 -1.3 -0.3 -0.6
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.9 0.6 0.8 0.9 -0.0 1.0 0.2
Commuting to job workplace: Public transport 2.3 2.8 9.6 -1.5 0.5 0.8 1.0 3.1 1.8
Eye problems/disorders: Glaucoma 0.9 1.0 2.9 -0.4 -1.7 1.0 0.0 1.2 1.0
Medication: Blood pressure 0.9 1.8 5.9 0.8 1.2 -0.2 -1.4 -2.4 0.8
Pain type(s) experienced in last month: Hip pain 1.8 2.2 4.9 -1.9 -1.2 -1.1 0.5 -1.4 -2.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.5 0.0 0.9 -0.2 0.7 -1.2 -0.1
High cholesterol (Self-reported) 0.7 1.2 3.6 -1.9 0.3 -1.4 0.4 -0.2 -1.1
Medication: Bendroflumethiazide 0.4 0.7 3.1 -0.5 0.1 -0.2 -0.7 -1.8 0.1
Medication: Paracetamol 0.3 0.5 2.0 -0.0 -1.4 0.2 0.8 -0.2 0.1
Medication: Lisinopril 0.5 0.7 1.5 1.2 0.7 0.2 0.9 -0.9 0.7
Medication: Atorvastatin 0.3 0.4 0.9 -0.2 -0.8 0.8 0.4 0.2 -0.9
Illnesses of father: High blood pressure 1.6 2.0 6.0 2.3 -0.3 2.5 -0.4 0.2 0.6
Alcohol drinker status: Never 0.9 1.0 3.5 1.0 1.9 0.2 -0.3 -1.0 0.7
Ever smoked 0.8 1.4 4.2 -1.3 -2.0 0.0 1.3 0.7 -0.1
Basal metabolic rate 0.9 4.9 15.0 1.8 -1.5 3.9 0.8 1.8 2.3
Leg fat percentage (left) 0.3 1.1 2.9 1.1 -1.2 1.0 -1.7 -0.2 0.4
Arm fat-free mass (left) 0.9 4.3 12.1 1.9 -1.4 3.5 0.2 1.8 2.2
Number of operations (self-reported) 1.4 2.1 6.1 -1.5 -1.7 -0.9 -0.2 0.9 -2.5
Average weekly beer plus cider intake 0.4 0.5 1.3 0.8 0.6 0.6 -1.2 0.6 0.4
Irritability 0.5 0.9 2.3 -1.1 -0.9 0.3 1.5 0.7 -0.5
Risk taking 0.8 1.2 5.2 -1.3 -0.4 -0.6 2.3 0.2 0.1
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.6 -1.6 -0.4 -1.6 -1.3 1.1 -0.3
Fractured/broken bones in last 5 years 0.2 0.3 0.8 -0.4 0.9 -0.6 0.5 -0.1 -0.3
Age started oral contraceptive pill 1.1 1.4 4.4 2.1 0.6 1.1 -1.2 0.2 1.1
Diastolic blood pressure, automated reading 0.7 2.2 6.1 1.3 1.8 0.5 -2.5 -1.3 0.0
Ever depressed for a whole week 0.6 0.7 2.3 -0.4 1.2 -1.5 -0.5 -0.4 -0.2
Unable to work because of sickness or disability 0.5 0.7 1.5 -0.2 1.2 -0.8 1.1 0.5 -0.7
Commuting to job workplace: Cycle 1.1 1.3 3.6 0.5 0.8 0.7 -0.1 -1.9 1.6
Myopia 0.4 0.5 1.1 0.6 1.1 0.6 0.5 0.3 1.0
Vascular/heart problems diagnosed by doctor 0.7 1.9 6.4 -0.2 -0.5 -0.5 2.1 2.5 -0.6
Cholesterol lowering medication 0.9 1.3 3.7 -0.9 -0.1 -1.6 -1.9 -0.3 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.4 -0.4 1.0 -0.3 1.9 0.9 0.5
Pain experienced in last month 0.7 1.2 2.7 0.8 -0.9 1.4 -0.2 1.6 1.1
Supplements: Calcium 2.9 3.2 8.1 2.8 1.6 2.1 -0.9 -1.1 1.3
Basal cell carcinoma (self-reported) 1.0 1.1 2.9 1.7 0.1 1.6 -1.0 -0.5 -0.3
Heart attack/myocardial infarction (self-reported) 1.4 1.8 8.9 0.8 0.3 1.1 -0.2 -3.0 0.3
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 6.2 1.8 0.4 2.5 1.7 0.6 2.0
Heart disease (siblings) 0.2 0.3 1.3 -0.0 1.1 -0.5 -0.3 0.2 -0.4
Alcohol drinker status: Previous 0.4 0.4 1.5 0.9 -0.2 -0.1 -0.5 1.2 -0.3
Pack years of smoking 0.9 1.3 2.8 -1.5 0.2 -1.2 0.3 1.7 -1.0
Impedance of whole body 0.8 4.1 12.0 -2.5 1.3 -3.5 1.0 0.5 -2.0
Leg fat mass (left) 0.6 2.3 6.4 1.9 -1.1 2.5 -0.9 0.4 1.3
Arm predicted mass (left) 1.0 4.9 13.2 2.2 -1.3 3.6 0.3 1.8 2.5