TWAS hub - COPA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0310	8.0e-04	0.077	0.008	0.065	0.072	0.080	1.2e-09	3.1e-02	2.2e-08	4.6e-09	6.1e-10
2	GTEx	Nerve Tibial	0.1430	0.0448	8.3e-05	0.085	NA	0.095	NA	0.096	1.3e-06	NA	3.0e-07	NA	2.6e-07
3	GTEx	Whole Blood	0.1510	0.0440	3.6e-06	0.105	NA	0.082	NA	0.096	6.7e-10	NA	5.1e-08	NA	3.8e-09
4	NTR	Blood	0.0232	0.0085	3.9e-04	0.006	0.009	0.010	0.009	0.011	2.9e-03	4.1e-04	2.4e-04	3.6e-04	1.3e-04
5	YFS	Blood	0.0501	0.0106	1.1e-16	0.067	0.051	0.068	0.060	0.063	6.6e-21	3.0e-16	2.1e-21	5.3e-19	8.5e-20
6	TCGA	Prostate Adenocarcinoma	0.0462	0.0250	4.1e-03	0.035	0.014	0.016	NA	0.026	1.4e-04	1.2e-02	7.1e-03	NA	8.3e-04
7	TCGA	Skin Cutaneous Melanoma	0.2450	0.1170	2.6e-03	-0.007	0.073	0.024	NA	0.015	5.6e-01	5.4e-03	7.6e-02	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Neuroticism (2016)	6.2	8.9	14.7	0.3	3.5	-3.7	-3.6	-3.8	-0.2	-3.0
Illnesses of father: High blood pressure	5.0	6.2	10.9	-1.5	-3.1	3.3	3.0	3.0	-1.0	1.2
Schizophrenia (2018)	4.7	9.9	20.1	1.6	-2.6	2.7	3.4	3.3	3.1	4.5
Breastfed as a baby	4.6	5.7	9.2	1.2	3.0	-2.9	-2.8	-2.9	0.3	-2.1
Waist Hip Ratio (WHR)	4.4	20.0	31.2	1.0	-4.9	4.8	5.2	5.2	2.4	5.6
Hand grip strength (right)	4.4	12.0	33.8	5.8	2.2	-2.5	-1.8	-1.6	5.3	2.3
Suffer from ‘nerves’	4.3	6.7	11.8	-0.2	2.8	-3.0	-2.9	-3.0	-1.0	-3.4
Loneliness, isolation	4.2	5.8	9.9	-0.4	2.6	-2.7	-2.6	-2.8	-1.2	-3.1
Schizophrenia (2014)	3.9	8.5	16.4	1.1	-2.8	2.7	3.2	3.2	2.6	4.0
Worry too long after embarrassment	3.9	6.5	10.8	1.6	3.1	-3.3	-2.6	-3.1	0.8	-2.4
Hayfever, allergic rhinitis or eczema	3.5	7.7	12.2	0.3	3.5	-3.3	-3.5	-3.4	-0.0	-2.6
Bipolar Disorder or Schizophrenia	3.4	8.4	14.9	1.2	-2.6	2.8	3.4	3.2	2.5	3.9
Medication for cholesterol	3.4	5.1	9.5	0.4	2.3	-2.5	-3.1	-2.8	-0.5	-2.6
Allergy or Eczema	3.2	8.5	13.7	1.2	3.6	-3.6	-3.7	-3.5	0.4	-2.3
Health satisfaction	3.0	3.9	6.9	-0.3	-2.6	2.3	2.0	2.5	0.5	2.1
Allergy	2.9	6.6	11.6	-1.0	-3.4	3.2	3.0	3.2	-0.5	1.9
Impedance of arm (left)	2.9	13.6	37.8	-6.2	-1.5	1.7	0.8	0.5	-6.2	-3.7
Had major operations	2.9	3.4	6.0	0.3	-1.9	1.8	2.3	2.1	1.1	2.5
Hand grip strength (left)	2.8	7.4	20.6	4.5	1.9	-2.2	-1.4	-1.5	4.0	1.7
Stomach or abdominal pain in last month	2.8	3.5	6.1	0.4	-2.1	1.9	2.1	2.1	1.0	2.5
Impedance of arm (right)	2.8	12.9	37.6	-5.8	-0.9	1.1	0.3	-0.0	-6.1	-4.1
Mouth/teeth dental problems: Dentures	2.8	4.7	7.4	1.7	2.7	-2.6	-2.7	-2.3	1.2	-1.3
Illnesses of father: None of the above (group 1)	2.8	3.5	5.5	-0.4	1.9	-2.0	-2.3	-2.1	-1.3	-2.3
Chronic bronchitis/emphysema (father)	2.7	3.2	5.1	-0.5	-2.3	2.2	1.8	2.2	0.6	2.0
Basal cell carcinoma (self-reported)	2.6	3.1	6.0	-0.4	-2.1	2.1	2.4	2.1	0.3	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	7.3	-0.5	1.9	-2.0	-1.6	-2.2	-1.1	-2.7
Hypothyroidism/myxoedema (self-reported)	2.5	5.0	8.0	1.4	-1.9	1.9	2.3	2.4	2.5	2.8
Hypothyroidism (self reported)	2.4	5.6	11.0	1.8	-1.7	1.8	2.2	2.3	2.9	3.3
Nervous feelings	2.4	4.4	7.4	0.5	2.6	-2.7	-2.3	-2.5	0.3	-2.2
Hair/balding pattern: Pattern 3	2.4	3.6	10.0	3.2	1.4	-1.6	-0.7	-1.0	2.5	1.7
Wears glasses or contact lenses	2.4	2.7	6.8	-1.9	0.9	-0.7	-1.2	-1.2	-2.6	-2.1
Neuroticism (Nagel 2018)	2.3	5.5	8.7	0.1	2.6	-2.8	-2.7	-2.7	-0.8	-2.9
Breast Cancer	2.3	5.5	8.5	1.1	-2.7	2.4	2.5	2.8	1.6	2.9
Mean Putamen Volume	2.3	2.7	4.8	-0.4	-2.0	1.9	1.6	1.8	0.0	2.2
Type 2 Diabetes (T2D) (2012)	2.3	2.7	5.0	1.0	2.0	-1.8	-2.2	-2.0	-0.1	-1.3
Current tobacco smoking	2.3	3.7	6.1	0.3	-2.4	2.3	1.9	2.5	0.4	2.3
Supplements: Vitamin C	2.3	2.8	5.1	1.2	2.3	-2.1	-1.7	-2.1	0.6	-0.9
Commuting to job workplace: Walk	2.3	2.5	3.9	-1.5	-1.6	1.9	2.0	1.6	-1.6	0.5
Medication: Levothyroxine sodium	2.2	3.8	7.2	1.5	-1.4	1.4	1.7	1.9	2.7	2.6
Mean time to correctly identify matches	2.1	4.0	5.9	2.4	2.4	-2.4	-1.8	-2.2	1.8	-0.4
Medication: Gliclazide	2.1	2.4	7.6	2.8	1.1	-1.2	-1.3	-0.9	1.8	0.7
Smoking status: Current	2.1	3.3	5.3	0.4	-2.1	2.1	1.9	2.3	0.6	2.2
High cholesterol (Self-reported)	2.1	3.7	6.3	0.3	-2.0	2.1	2.5	2.5	1.2	1.7
Lung cancer (father)	2.0	2.4	3.8	-0.2	1.7	-1.7	-1.9	-1.9	0.3	-1.9
Lupus	1.9	2.9	4.8	0.9	-1.7	1.6	2.2	2.0	1.5	1.9
Type 2 Diabetes (T2D) (2018)	1.9	3.6	5.9	-0.1	2.1	-2.1	-2.3	-2.2	-0.7	-2.4
Neuroticism	1.9	4.6	7.9	0.8	2.6	-2.8	-2.5	-2.6	0.2	-1.9
Ever used hormone-replacement therapy (HRT)	1.9	2.4	3.8	-0.4	1.9	-1.7	-1.7	-1.7	-0.8	-1.8
Cholesterol lowering medication	1.9	2.9	5.0	-0.4	-1.9	2.1	2.0	2.2	0.3	1.7
Bipolar Disorder (2011)	1.8	1.8	3.3	1.2	-0.8	1.0	1.4	1.4	1.5	1.8
Pack years adult smoking proportion	1.8	2.8	4.7	-0.5	-2.2	2.2	1.7	1.9	-1.0	1.4
Asthma	1.8	3.6	6.9	1.4	2.6	-2.4	-1.8	-2.5	0.7	-1.0
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.0	-0.6	-1.8	1.9	2.0	1.7	-0.0	0.9
Intelligence (Savage-Jansen 2018)	1.7	5.2	9.1	1.0	3.0	-2.9	-2.5	-2.9	-0.5	-1.7
Heel T-Score	1.7	13.7	22.0	1.3	4.6	-4.7	-4.3	-4.4	0.5	-3.6
Sensitivity / hurt feelings	1.7	3.0	4.4	-0.6	1.6	-2.0	-2.1	-1.9	-1.5	-1.9
Fluid intelligence score	1.7	3.6	6.4	0.9	2.5	-2.3	-2.0	-2.5	-0.1	-1.7
Neuroticism score	1.7	3.5	6.6	0.5	2.2	-2.6	-2.1	-2.3	-0.1	-1.7
Glaucoma (self-reported)	1.7	2.0	3.8	0.3	-1.5	1.6	1.8	1.5	0.1	1.9
Asthma (self-reported)	1.7	3.3	6.4	1.2	2.5	-2.3	-1.7	-2.4	0.4	-1.0
Myopia	1.7	2.5	4.2	-1.2	-2.0	1.9	2.1	1.7	-0.8	0.8
Worry (Nagel 2018)	1.6	3.3	5.3	0.2	2.0	-2.3	-2.1	-2.2	-0.3	-2.2
Townsend deprivation index at recruitment	1.6	2.2	3.5	0.2	-1.6	1.7	1.7	1.9	0.6	1.8
Alcohol usually taken with meals	1.6	2.5	6.0	-0.9	1.7	-1.5	-1.2	-1.7	-1.2	-2.4
Mouth/teeth dental problems	1.6	2.4	4.8	-1.9	-1.4	1.7	1.3	1.4	-2.2	-0.0
Noisy workplace	1.6	1.9	3.9	1.0	-0.9	0.9	1.6	1.1	1.7	2.0
Prospective memory result	1.6	2.0	3.9	-0.6	-1.8	1.8	2.0	1.7	0.1	0.6
Osteoporosis (self-reported)	1.6	1.9	3.3	0.2	1.7	-1.7	-1.7	-1.8	-0.2	-1.2
Maternal smoking around birth	1.5	2.1	3.2	0.7	1.8	-1.6	-1.7	-1.6	0.4	-1.7
Length of working week for main job	1.5	1.7	3.6	-0.6	1.4	-1.4	-1.3	-1.5	-0.3	-1.9
Peak expiratory flow (PEF)	1.5	3.5	7.0	-0.2	2.1	-1.9	-2.0	-2.2	-0.7	-2.6
Age at last live birth	1.5	2.2	3.4	-0.2	1.8	-1.5	-1.4	-1.8	-0.9	-1.8
Pack years of smoking	1.5	2.2	3.8	-0.7	-1.9	2.0	1.6	1.6	-1.2	1.0
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.2	-0.0	1.8	-1.6	-1.0	-1.4	0.2	-1.5
Arm fat-free mass (right)	1.4	7.4	14.7	2.6	-1.8	1.6	2.2	2.4	3.8	3.7
Qualifications: College or University degree	1.4	4.3	8.1	0.4	2.8	-2.7	-1.9	-2.8	0.0	-1.6
Arm predicted mass (right)	1.4	7.2	16.2	2.6	-1.6	1.5	2.1	2.3	4.0	3.5
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.1	-1.0	1.1	-1.1	-1.5	-1.3	-1.5	-1.8
Schizophrenia vs Biploar Disorder	1.3	1.7	3.0	-0.3	-1.7	1.5	1.2	1.5	0.1	1.7
Crohns Disease (2017)	1.3	2.9	6.8	-2.6	0.6	-0.4	-1.0	-1.0	-2.6	-2.0
Respiratory disease	1.3	2.9	5.6	0.5	2.3	-2.1	-1.8	-2.4	-0.2	-1.3
Fed-up feelings	1.3	2.3	5.2	-0.3	1.6	-1.7	-1.3	-1.8	-0.9	-2.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	-1.0	1.3	-1.3	-1.1	-1.2	-0.7	-1.6
Supplements: Glucosamine	1.3	1.7	4.1	-1.3	0.7	-0.6	-1.4	-1.1	-2.0	-1.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.6	-0.3	1.6	-1.5	-1.6	-1.6	-0.7	-1.3
Pulse wave reflection index	1.3	1.6	3.2	0.0	-1.4	1.5	1.8	1.6	0.7	0.9
Headache pain in last month	1.3	2.2	3.5	-1.6	-1.8	1.7	1.9	1.4	-1.2	0.5
Medication: Seretide 50 evohaler	1.3	1.4	3.1	1.8	1.3	-1.3	-0.8	-1.3	1.1	0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.3	0.8	1.1	-1.2	-2.1	-1.3	-0.4	-1.0
Alcohol drinker status: Never	1.3	1.5	6.1	2.5	-0.0	-0.1	0.4	0.3	1.7	1.2
Number of operations (self-reported)	1.3	1.9	5.3	-2.3	-1.1	1.3	1.1	1.2	-1.4	-0.1
Unable to work because of sickness or disability	1.3	1.7	5.7	1.9	0.8	-0.8	-0.1	-0.2	2.4	1.1
Impedance of whole body	1.3	6.4	17.7	-4.2	-0.8	0.9	0.2	0.1	-4.2	-2.8
Depressed Affect (Nagel 2018)	1.2	2.5	5.4	-0.5	1.6	-1.7	-1.6	-1.8	-1.0	-2.3
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.0	0.6	2.2	-2.0	-1.7	-2.2	-0.4	-1.8
Chronotype (morning person)	1.2	2.9	4.5	0.5	2.1	-2.1	-2.0	-2.1	0.8	-1.4
Waist circumference	1.2	4.3	7.5	0.4	-2.2	2.3	2.1	2.6	0.9	2.7
Medication: Simvastatin	1.2	1.7	2.9	0.6	-1.2	1.4	1.7	1.6	0.9	1.4
Number of full sisters	1.2	1.4	3.6	1.9	0.8	-1.2	-0.4	-0.7	1.9	0.1
Eye problems/disorders: Cataract	1.2	1.4	2.4	-0.0	-1.4	1.3	1.1	1.4	0.9	1.6
Arm fat-free mass (left)	1.2	6.0	14.6	2.7	-1.2	1.0	1.7	1.8	3.8	3.3
Ever depressed for a whole week	1.2	1.4	4.0	2.0	0.6	-0.8	-0.4	-0.3	1.9	1.1
Arm predicted mass (left)	1.2	5.9	13.1	2.5	-1.4	1.2	1.9	1.9	3.6	3.4
Lung FVC	1.1	5.6	7.6	0.4	-2.7	2.6	2.8	2.7	1.8	2.7
Supplements: Zinc	1.1	1.2	1.9	-1.3	-1.4	1.3	1.0	1.2	-0.5	0.7
Had other major operations	1.1	1.4	2.7	-1.6	-1.1	1.4	1.1	1.3	-0.9	0.2
Time employed in main current job	1.1	1.3	2.8	-1.2	0.6	-0.6	-1.4	-0.9	-1.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.3	-1.0	0.7	-0.8	-0.7	-1.0	-2.1	-1.0
Exposure to tobacco smoke at home	1.1	1.3	3.0	0.1	-1.2	1.2	1.3	1.0	-0.2	1.7
Medication: Paracetamol	1.1	1.8	2.9	-1.1	-1.7	1.7	1.5	1.4	-0.9	0.7
Number of full brothers	1.1	1.4	4.9	2.2	0.6	-0.9	-0.4	-0.8	1.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.0	-0.1	-1.1	1.0	1.7	1.2	0.8	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.8	1.9	0.7	-0.8	-0.3	-0.3	1.9	1.0
Smoking status: Previous	1.1	1.6	2.5	-0.7	1.2	-1.1	-1.2	-1.6	-1.4	-1.6
Average weekly spirits intake	1.0	1.2	2.7	0.0	-1.1	1.1	1.6	1.4	0.5	1.1
Multivitamins +/- minerals	1.0	1.3	2.1	-0.1	-1.4	1.3	1.2	1.3	0.2	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	4.5	1.6	2.1	-1.9	-1.4	-1.6	1.2	-0.5
Trunk fat-free mass	1.0	5.5	11.2	2.2	-1.6	1.4	2.1	2.0	3.3	3.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.2	-0.8	1.2	-1.2	-1.1	-1.2	-1.0	-2.0
Age at first live birth	1.0	1.8	3.3	0.1	1.8	-1.6	-1.3	-1.6	-0.2	-1.5
Eye problems/disorders: None of the above	1.0	1.2	2.3	-0.2	1.1	-1.1	-1.1	-1.3	-0.9	-1.5
Irritability	1.0	1.7	3.3	0.2	1.5	-1.6	-1.8	-1.5	0.2	-1.2
LDL Cholesterol	0.9	1.4	5.4	1.8	0.5	-0.5	-0.1	-0.1	2.3	0.8
Diabetes (mother)	0.9	1.1	1.7	-0.6	-1.3	1.3	0.8	1.3	-0.4	1.2
Trunk fat percentage	0.9	3.5	5.6	-1.7	-2.2	2.4	1.9	2.2	-1.4	0.9
Taking other prescription medications	0.9	1.4	2.8	0.5	-1.0	1.1	1.7	1.3	1.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.5	1.9	1.8	-1.6	-1.2	-1.2	1.5	-0.2
Medication: Atenolol	0.9	1.1	2.0	-0.7	-1.2	1.4	1.3	1.2	-0.7	-0.1
Leg predicted mass (left)	0.9	4.6	7.1	0.2	-2.5	2.4	2.7	2.6	1.1	2.4
Trunk fat mass	0.9	3.8	6.5	-0.8	-2.4	2.5	2.2	2.6	-0.3	1.6
Hair/balding pattern: Pattern 2	0.9	1.1	1.7	-0.5	-1.2	1.3	1.3	1.3	-0.9	0.6
Worrier / anxious feelings	0.9	1.7	3.2	0.4	1.6	-1.8	-1.2	-1.6	0.0	-1.4
Trunk predicted mass	0.9	5.3	10.8	2.1	-1.6	1.4	2.0	2.0	3.3	3.0
Whole body fat-free mass	0.9	5.2	8.6	1.5	-2.0	1.8	2.4	2.4	2.6	2.9
Whole body water mass	0.9	5.2	8.6	1.6	-1.9	1.8	2.3	2.3	2.8	2.9
Basal metabolic rate	0.9	4.8	8.0	1.3	-2.0	1.9	2.3	2.3	2.3	2.8
Diastolic blood pressure, automated reading	0.9	2.7	5.0	-1.0	-2.2	2.2	1.6	2.0	-0.9	1.0
Alzheimer’s Disease (in mother)	0.8	1.0	3.1	-1.8	0.2	-0.1	-0.2	-0.4	-1.6	-1.1
Primary Biliary Cirrhosis	0.8	1.2	2.1	-1.2	-1.4	1.4	1.1	1.2	-0.3	0.3
Height	0.8	16.1	26.6	-2.7	-5.2	5.1	4.9	5.0	-0.5	1.9
Lung FEV1/FVC ratio	0.8	4.3	7.3	1.6	2.5	-2.5	-2.7	-2.4	0.4	-1.2
Leg fat-free mass (left)	0.8	4.5	6.8	0.2	-2.4	2.4	2.6	2.6	1.1	2.3
Medication: Amlodipine	0.8	1.2	2.3	-1.5	-0.9	1.0	1.1	0.7	-1.5	-0.2
Comparative body size at age 10	0.8	2.1	4.0	0.9	1.9	-2.0	-1.8	-1.7	0.3	-0.7
Whole body fat mass	0.8	3.1	5.5	-0.5	-2.2	2.2	1.9	2.3	-0.0	1.7
Chest pain or discomfort	0.8	1.1	1.8	1.0	1.3	-1.3	-1.2	-1.2	0.7	-0.5
Illnesses of siblings: Diabetes	0.8	1.0	1.8	0.6	1.2	-1.4	-1.2	-1.1	0.2	-0.5
Leg fat-free mass (right)	0.8	4.2	6.8	-0.0	-2.4	2.3	2.6	2.5	1.0	2.1
Leg predicted mass (right)	0.8	4.4	6.9	0.0	-2.4	2.3	2.6	2.6	1.1	2.1
Alcohol drinker status: Previous	0.8	0.9	1.9	-0.8	-1.2	1.2	0.5	0.8	-1.4	0.3
Irritable Bowel Disease (IBD)	0.7	1.6	2.2	-1.4	1.0	-0.8	-1.2	-1.3	-1.5	-1.5
Body Mass Index (BMI) (2010)	0.7	0.9	3.0	1.7	0.8	-0.7	-0.6	-0.6	1.2	0.5
Crohns Disease (2012)	0.7	1.1	2.4	-0.9	0.9	-0.8	-0.9	-1.1	-1.6	-1.0
HDL Cholesterol	0.7	1.1	3.3	-1.8	-1.0	1.2	0.6	0.9	-0.8	0.5
Ever had hysterectomy (womb removed)	0.7	0.8	2.2	-1.1	0.8	-0.6	-0.5	-0.8	-0.7	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	-1.0	0.8	-0.6	-0.6	-0.9	-1.0	-1.2
Financial difficulties in last 2 years	0.7	0.9	1.5	-1.2	-0.9	0.9	0.8	0.8	-1.1	-0.8
Hair/balding pattern: Pattern 4	0.7	1.7	3.4	0.8	1.5	-1.5	-1.9	-1.4	0.9	-0.3
Loud music exposure frequency	0.7	0.8	1.3	0.2	1.0	-1.1	-1.0	-1.1	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.2	-1.4	-1.5	1.4	1.0	1.4	-0.7	-0.3
Diabetes diagnosed by doctor	0.7	1.2	1.9	-0.3	1.2	-1.1	-1.2	-1.3	-0.8	-1.4
Mother’s age at death	0.7	0.9	1.7	0.4	-1.0	0.9	0.8	1.3	0.6	1.1
Fractured/broken bones in last 5 years	0.7	0.9	1.9	1.4	0.9	-1.0	-0.4	-0.8	1.1	0.4
Depression (Nagel 2018)	0.6	1.0	2.6	0.0	0.9	-1.0	-1.1	-1.0	-0.3	-1.6
Blood Platelet Count	0.6	7.0	17.0	4.1	2.4	-2.4	-1.8	-1.7	3.7	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-0.5	1.2	-0.9	-0.7	-1.1	-0.4	-1.1
Angina	0.6	0.8	2.0	0.3	-0.9	0.8	0.8	1.0	0.6	1.4
Average weekly fortified wine intake	0.6	0.7	1.4	-1.1	-0.4	0.3	0.5	0.4	-1.1	-1.2
Birth weight of first child	0.6	1.1	2.0	-1.1	-1.0	1.1	1.4	0.9	-1.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.4	-0.7	0.6	-0.9	-0.3	-0.9	-0.2	-1.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.5	0.4	1.2	-1.2	-0.8	-1.1	0.3	-0.3
High blood pressure (siblings)	0.6	0.8	1.5	-1.2	-0.9	1.0	1.2	0.8	-0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.8	1.7	0.4	-0.3	-0.0	-0.2	1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.2	-1.0	0.1	-0.1	-0.7	-0.5	-1.5	-1.2
Mineral and other dietary supplements	0.6	0.8	1.2	0.2	-1.1	1.0	1.0	1.0	0.5	1.1
Guilty feelings	0.6	0.9	1.5	0.1	1.1	-1.2	-1.2	-1.1	-0.3	-0.9
Commuting to job workplace: Public transport	0.6	0.7	2.0	-1.4	-0.1	0.3	0.7	0.1	-1.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	0.4	1.1	-1.1	-0.9	-1.0	0.3	-0.9
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.5	-0.9	0.9	-1.1	-1.5	-1.2	-1.0	-1.9
Alzheimer’s Disease (in father)	0.5	0.5	0.9	-0.4	-0.8	0.7	0.7	0.7	0.6	1.0
Major Depression (MDD)	0.5	0.7	0.9	-0.1	-0.8	0.7	0.9	1.0	0.8	1.0
Blood Eosinophil Count	0.5	4.0	6.9	-0.4	-2.4	2.6	2.6	2.4	0.8	1.6
Systolic Blood Pressure	0.5	2.5	4.8	-2.2	-1.6	1.8	1.3	1.1	-2.0	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.0	0.9	0.9	-1.0	-0.9	-0.9	0.5	-0.1
Medication: Metformin	0.5	0.8	1.3	0.5	1.2	-1.1	-1.1	-1.0	-0.1	-0.7
High blood pressure	0.5	1.4	2.8	1.2	-0.7	0.9	1.2	1.1	1.2	1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.1	1.4	0.4	-0.6	0.1	-0.3	0.9	0.8
Diabetes (self-reported)	0.5	0.8	1.3	-0.2	1.0	-0.9	-1.1	-1.0	-0.4	-1.1
Falls in the last year	0.5	0.7	1.6	-1.3	-0.8	0.7	0.5	0.5	-1.1	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	1.0	0.7	-0.9	-0.5	-0.9	1.0	0.4
Angina (self-reported)	0.5	0.7	1.9	0.2	-0.8	0.8	0.7	0.9	0.5	1.4
Medication: Allopurinol	0.5	0.7	1.1	-0.9	-0.9	1.0	0.5	0.7	-1.0	0.8
Leg fat mass (right)	0.5	1.9	3.8	0.7	-1.4	1.4	1.2	1.7	0.9	1.9
Alcohol intake frequency.	0.5	1.2	2.4	0.3	-1.4	1.2	1.1	1.3	0.0	1.5
Arm fat percentage (left)	0.5	2.1	3.3	-1.4	-1.6	1.8	1.2	1.6	-1.4	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.9	0.9	-0.4	0.3	0.5	0.4	1.3	1.4
Arm fat mass (left)	0.5	2.3	3.9	-0.5	-1.8	1.9	1.6	2.0	-0.1	1.5
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	1.1	-0.5	0.5	1.0	0.8	1.3	1.2
Commuting to job workplace: Cycle	0.5	0.6	0.9	-0.5	0.8	-0.9	-0.8	-0.9	-0.5	-1.0
Pain experienced in last month	0.5	0.8	1.5	0.0	1.2	-1.1	-1.2	-1.0	-0.1	-0.8
Heart disease (siblings)	0.5	0.6	1.5	1.0	0.2	-0.3	0.3	0.0	1.2	1.2
Bipolar Disorder (2018)	0.4	0.7	1.6	-0.2	-0.8	1.0	1.3	1.0	0.2	0.6
Ulcerative Colitis (UC)	0.4	0.8	1.6	0.1	1.0	-1.2	-1.3	-1.2	0.1	-0.5
Reaction Time	0.4	0.7	1.4	1.2	0.9	-1.0	-0.6	-0.9	0.8	-0.1
Ulcerative Colitis	0.4	0.5	0.9	0.6	0.8	-0.9	-0.9	-0.9	0.5	0.2
Severe depression (siblings)	0.4	0.5	1.6	0.9	-0.2	0.1	-0.1	0.3	1.3	0.8
Had menopause	0.4	0.5	0.9	0.5	1.0	-0.7	-0.8	-0.8	0.2	-0.4
Pain all over the body in last month	0.4	0.4	1.2	-0.1	0.6	-0.5	-0.5	-0.6	-0.3	-1.1
Weight	0.4	2.0	3.3	0.7	-1.3	1.3	1.5	1.6	1.2	1.8
Number of live births	0.4	0.6	1.2	-0.8	-1.1	1.1	0.3	0.7	-0.9	-0.2
Arm fat mass (right)	0.4	1.7	2.8	-0.2	-1.5	1.6	1.4	1.7	-0.0	1.4
Standing height	0.4	4.0	8.3	-1.1	-2.5	2.4	2.9	2.4	0.6	0.8
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.5	0.9	-0.9	-0.7	-0.8	-0.2	-0.4
Gout (self-reported)	0.4	0.5	1.7	-1.2	-0.4	0.5	-0.2	0.2	-1.3	-0.4
Body fat percentage	0.4	1.7	3.0	-0.7	-1.6	1.7	1.3	1.7	-0.7	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.3	-0.2	0.8	-0.9	-0.7	-0.9	-0.1	-1.1
Number of children fathered	0.4	0.4	1.8	1.3	-0.1	0.1	0.1	-0.0	0.7	0.9
Neck or shoulder pain in last month	0.4	0.5	2.0	1.4	0.2	-0.5	-0.1	-0.3	1.0	0.7
Migraine (self-reported)	0.4	0.6	1.8	1.3	-0.1	0.1	0.3	0.1	0.8	1.1
Heart disease (mother)	0.4	0.4	1.7	1.3	0.3	-0.4	-0.1	-0.3	0.5	0.9
Overall health rating	0.4	0.8	1.5	0.3	-1.1	0.9	0.8	1.1	0.6	1.2
Ever had bowel cancer screening	0.4	0.4	1.0	-0.7	0.7	-0.6	-0.7	-0.5	0.3	-1.0
Friendships satisfaction	0.4	0.5	1.1	1.0	0.7	-0.8	-0.5	-0.6	0.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.1	0.9	1.0	-1.0	-0.9	-0.9	0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.7	1.3	-0.1	0.0	-0.1	0.0	1.2	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	-0.2	-0.8	0.8	0.6	0.7	-0.4	1.1
Supplements: Calcium	0.4	0.5	0.9	-0.0	0.9	-0.8	-0.7	-0.9	-0.7	-0.1
Leg fat mass (left)	0.4	1.7	3.3	0.7	-1.3	1.3	1.1	1.6	0.9	1.8
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-1.2	0.4	-0.4	-0.3	-0.5	-0.7	-0.5
Systolic blood pressure, automated reading	0.3	0.8	1.6	-1.2	-0.8	1.0	0.3	0.6	-1.3	-0.4
Diabetes (father)	0.3	0.3	0.7	0.1	-0.6	0.8	0.5	0.6	0.4	0.5
Age when periods started (menarche)	0.3	0.8	2.4	1.5	0.5	-0.5	0.3	-0.4	1.5	0.1
Past tobacco smoking	0.3	0.6	1.8	0.8	-0.3	0.3	0.6	0.7	1.4	0.7
Hearing difficulty/problems with background noise	0.3	0.4	0.7	-0.4	-0.8	0.8	0.6	0.8	-0.1	0.8
Arm fat percentage (right)	0.3	1.2	1.8	-1.1	-1.2	1.4	0.9	1.2	-1.3	0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.7	-0.5	0.7	0.9	0.5	-0.0	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.1	0.6	-0.9	-0.9	-0.6	-0.2	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.5	-1.1	-0.2	0.0	-0.4	-0.3	-1.2	-0.4
Birth weight	0.3	0.6	1.3	0.7	-0.4	0.5	0.7	0.6	1.1	1.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.0	-0.8	0.1	0.1	-0.2	-0.2	-1.0	-0.6
Leg fat percentage (right)	0.3	1.0	2.9	1.4	-0.5	0.6	0.3	0.8	1.0	1.7
Exposure to tobacco smoke outside home	0.3	0.4	1.5	0.8	0.2	-0.1	-0.1	-0.0	1.2	0.5
Shortness of breath walking on level ground	0.3	0.4	1.1	-0.3	0.5	-0.6	-0.5	-0.7	-0.3	-1.0
Medication: Blood pressure	0.3	0.6	2.1	1.2	0.4	-0.2	0.3	0.0	1.4	0.4
Hypertension (Self-reported)	0.3	0.8	1.4	0.8	-0.5	0.7	1.1	0.9	1.0	1.2
Qualifications: nursing, teaching	0.3	0.4	1.2	-1.0	0.1	0.0	-0.0	-0.3	-1.1	-0.8
Back pain experienced in last month	0.3	0.5	0.7	0.7	0.9	-0.7	-0.7	-0.7	0.8	0.3
Breast cancer (self-reported)	0.3	0.4	1.2	-0.8	0.4	-0.3	-0.2	-0.4	-0.8	-1.1
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.9	0.7	-0.7	-0.5	-0.7	-0.3	-0.5
Average weekly champagne plus white wine intake	0.3	0.5	0.8	-0.9	0.4	-0.5	-0.7	-0.4	-0.9	-0.7
Medication: Blood pressure	0.3	0.6	1.2	-0.8	-0.8	0.9	1.1	0.8	-0.4	0.5
Medication: Atorvastatin	0.3	0.4	1.0	-1.0	-0.5	0.5	0.2	0.6	-0.9	-0.3
Leg fat percentage (left)	0.3	1.0	2.6	1.4	-0.4	0.5	0.3	0.8	1.2	1.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	0.3	0.8	-0.7	-0.5	-0.7	-0.4	-0.3
Age at First Birth	0.2	0.2	0.5	0.3	-0.3	0.3	0.6	0.6	0.4	0.7
BMI	0.2	1.3	3.3	1.8	0.8	-0.8	-1.0	-0.3	1.5	1.1
Cardiovascular Disease	0.2	0.8	2.1	1.0	-0.5	0.7	0.7	0.9	1.4	0.7
Relative age of first facial hair	0.2	0.4	1.1	-0.7	-0.1	0.2	0.3	0.0	-1.1	-1.0
Vitamin and mineral supplements	0.2	0.3	0.7	-0.8	-0.4	0.5	0.1	0.3	-0.8	-0.6
Impedance of leg (right)	0.2	0.8	2.0	-0.8	0.5	-0.5	-0.8	-0.7	-1.1	-1.4
Relative age voice broke	0.2	0.4	0.6	-0.7	-0.8	0.7	0.6	0.7	-0.3	-0.1
Body mass index (BMI)	0.2	0.8	2.3	1.4	-0.2	0.3	0.2	0.6	1.1	1.5
Impedance of leg (left)	0.2	0.9	2.5	-1.2	0.4	-0.4	-0.7	-0.7	-1.1	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	-0.3	0.3	-0.4	-0.3	-0.5	-0.5	-0.9
Forced vital capacity (FVC)	0.2	0.9	1.8	-0.9	-1.3	1.2	1.1	1.0	-0.1	-0.1
Medication: Ramipril	0.2	0.2	0.7	0.1	0.8	-0.7	-0.3	-0.5	0.4	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.7	0.4	-0.2	-0.5	-0.5	-0.6	-0.8
Medication: Lansoprazole	0.2	0.2	1.1	0.6	0.2	-0.2	0.2	0.3	1.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.6	-0.6	0.5	0.4	0.5	-0.8	0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.8	0.4	-0.4	0.3	-0.2	0.8	0.5
Pulse wave peak to peak time	0.2	0.2	0.6	0.5	0.4	-0.6	-0.8	-0.5	-0.1	0.1
Medication: Ibuprofen	0.2	0.3	0.7	0.6	0.4	-0.6	-0.8	-0.6	0.0	-0.2
Medication: Omeprazole	0.2	0.2	0.4	0.6	0.4	-0.5	0.1	-0.4	0.7	0.4
Leg pain on walking	0.2	0.3	1.1	0.2	-0.4	0.4	1.0	0.6	0.3	0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.0	0.3	-0.3	0.5	0.2	0.4	1.0	0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.7	0.6	-0.7	-0.2	-0.4	0.8	-0.1
Miserableness	0.2	0.3	0.7	0.1	0.6	-0.9	-0.5	-0.8	-0.3	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.8	0.4	-0.4	-0.5	-0.3	0.4	0.3
Risk taking	0.2	0.3	0.6	-0.2	-0.7	0.6	0.6	0.7	0.2	0.6
Age started oral contraceptive pill	0.2	0.3	0.5	0.7	0.6	-0.2	-0.1	-0.3	0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.5	0.7	-0.7	-0.0	-0.6	0.6	0.1
Ovarian Cancer	0.1	0.1	0.3	-0.1	0.2	-0.4	-0.4	-0.4	0.2	-0.5
Prostate Cancer	0.1	0.2	0.6	0.8	0.2	-0.3	-0.3	-0.2	0.1	0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.2	0.6	0.0	-0.0	-0.5	-0.3	-0.1
Fasting Glucose	0.1	0.2	0.4	-0.6	-0.1	0.2	-0.3	-0.1	-0.7	-0.5
HbA1C	0.1	0.1	0.3	-0.6	-0.3	0.5	0.3	-0.1	-0.4	-0.1
Rheumatoid Arthritis	0.1	0.2	0.4	-0.0	-0.7	0.7	-0.2	0.6	0.1	0.1
Triglycerides	0.1	0.2	0.5	0.7	0.3	-0.6	-0.5	-0.4	0.5	-0.0
Blood White Count	0.1	0.8	3.5	1.1	0.6	-0.4	-0.0	-0.3	1.9	0.4
Smoking Status	0.1	0.3	0.7	0.1	-0.8	0.8	0.3	0.7	-0.2	0.7
Tanning	0.1	0.8	1.9	0.6	-0.8	0.6	0.5	0.9	1.4	1.3
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.2	-0.5	0.6	0.3	0.5	0.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.4	-0.1	0.2	0.6	0.2	0.6	0.2
Medication for hormone replacement therapy	0.1	0.1	0.2	0.2	0.4	-0.4	-0.1	-0.1	-0.1	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.4	-0.4	0.3	0.4	0.3	-0.0	-0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.5	0.0	-0.1	-0.1	-0.1	-0.5	0.2
High blood pressure (mother)	0.1	0.1	0.3	-0.3	-0.5	0.4	0.1	0.3	-0.4	-0.0
Number of incorrect matches in round	0.1	0.2	0.6	0.3	-0.3	0.2	0.4	0.5	0.8	0.2
Heart attack	0.1	0.2	0.7	-0.8	0.1	0.0	0.3	-0.2	-0.7	0.1
Father’s age at death	0.1	0.1	0.3	-0.0	0.1	-0.1	-0.5	-0.3	-0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.8	-0.5	-0.0	-0.1	-0.3	-0.3	-0.2	-0.9
Pulse rate	0.1	0.2	0.6	0.3	-0.1	0.3	0.5	0.2	0.5	0.8
Happiness	0.1	0.1	0.2	0.1	0.5	-0.5	-0.2	-0.3	-0.1	-0.4
Medication: Cholesterol lowering	0.1	0.1	0.4	0.4	-0.1	0.2	0.6	0.4	0.1	0.4
Depression (self-reported)	0.1	0.1	0.2	0.5	0.2	-0.4	-0.1	-0.2	0.3	0.2
Illnesses of mother	0.1	0.1	0.2	-0.1	0.3	-0.4	-0.0	-0.3	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	0.0	0.3	-0.4	-0.3	-0.5	0.3	-0.8
Tense / ‘highly strung’	0.1	0.2	0.5	0.1	0.2	-0.4	-0.7	-0.4	-0.7	0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	-0.2	-0.5	0.5	0.7	0.4	0.5	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.3	0.4	-0.3	-0.1	-0.3	0.3	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.7	0.5	-0.4	-0.5	-0.3	0.6	0.1
Pulse rate, automated reading	0.1	0.5	1.4	0.9	0.1	0.0	0.1	0.2	1.1	1.2
Comparative height size at age 10	0.1	0.4	0.6	-0.5	-0.8	0.7	0.7	0.8	0.7	0.1
Family relationship satisfaction	0.1	0.1	0.2	0.3	0.4	-0.4	-0.4	-0.4	-0.4	-0.3
Knee pain experienced in last month	0.1	0.1	0.4	-0.1	0.3	-0.2	-0.2	-0.4	-0.2	-0.7
Illnesses of father: Heart disease	0.1	0.2	0.4	0.6	-0.0	0.1	0.3	0.2	0.5	0.6
Average weekly red wine intake	0.1	0.2	0.4	0.5	0.4	-0.5	-0.0	-0.2	0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.2	0.1	0.1	0.2	0.2	0.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.4	0.1	-0.1	-0.1	-0.2	-0.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	0.0	0.1	-0.2	-0.1	-0.2	0.1	-0.7
Medication: Aspirin	0.1	0.2	0.6	-0.6	0.2	-0.1	-0.1	-0.1	-0.8	-0.4
Hearing aid user	0.1	0.1	0.2	0.2	-0.1	0.1	0.0	-0.0	0.4	-0.4
Financial situation satisfaction	0.1	0.1	0.4	0.6	0.3	-0.3	0.1	-0.3	-0.1	-0.4
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.4	0.4	-0.2	0.7	-0.2	0.4	0.2
Medication: Paracetamol	0.1	0.1	0.3	0.0	-0.4	0.4	0.4	0.2	-0.2	0.5
Ever smoked	0.1	0.1	0.5	-0.4	-0.2	0.1	0.1	-0.2	-0.7	0.1
Average weekly beer plus cider intake	0.1	0.1	0.3	0.4	-0.1	0.2	0.4	0.4	0.4	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.3	-0.3	0.3	0.1	0.1	-0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.8	0.1	-0.0	0.3	-0.2	-0.6	0.1
Blood Red Count	0.0	0.4	1.3	0.6	0.4	-0.5	-1.1	-0.5	0.3	-0.6
Hair Pigment	0.0	1.0	2.7	-1.2	-0.8	1.0	0.8	0.6	-1.6	-0.1
Number of treatments/medications taken	0.0	0.1	0.4	0.2	-0.0	0.1	0.7	0.2	-0.1	0.1
Medication: Co-codamol	0.0	0.1	0.3	0.1	-0.2	0.1	-0.0	-0.0	-0.1	-0.5
Sitting height	0.0	0.2	0.5	-0.5	0.2	-0.1	0.0	-0.4	-0.4	-0.7
Qualifications: None of the above	0.0	0.0	0.1	0.2	0.1	-0.1	-0.3	-0.0	0.3	0.3
Illnesses of siblings	0.0	0.1	0.3	0.2	-0.0	-0.0	-0.5	-0.0	-0.1	-0.4
Hip circumference	0.0	0.2	0.6	-0.5	0.1	0.0	-0.3	-0.0	-0.8	-0.5
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.4	-0.0	-0.1	0.2	-0.1	-0.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.4	-0.1	-0.3	0.1
Medication: Aspirin	0.0	0.1	0.2	-0.3	-0.0	0.1	0.2	0.1	-0.4	0.2
Mood swings	0.0	0.1	0.2	-0.4	0.1	-0.4	-0.0	-0.2	-0.5	-0.2
Medication: Lisinopril	0.0	0.1	0.2	0.3	0.0	-0.1	-0.0	-0.4	0.2	0.3

Hub : Genes

COPA

Models

Trait associations