Hub : Genes

VANGL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.374	0.0970	4.8e-04	0.269	NA	0.277	NA	0.269	1.4e-07	NA	8.5e-08	NA	1.4e-07
2	GTEx	Brain Cerebellum	0.463	0.0920	1.3e-06	0.388	NA	0.356	NA	0.374	1.6e-12	NA	2.2e-11	NA	5.1e-12
3	GTEx	Colon Sigmoid	0.315	0.1030	1.2e-03	0.179	NA	0.117	NA	0.169	6.4e-07	NA	6.4e-05	NA	1.4e-06
4	GTEx	Testis	0.220	0.0820	5.3e-03	0.005	NA	-0.001	NA	0.010	1.9e-01	NA	3.5e-01	NA	1.1e-01
5	TCGA	Prostate Adenocarcinoma	0.243	0.0559	0.0e+00	0.392	0.377	0.402	NA	0.398	1.7e-43	1.8e-41	5.8e-45	NA	2.3e-44
6	TCGA	Thyroid Carcinoma	0.073	0.0300	7.3e-07	0.076	0.062	0.050	NA	0.080	7.1e-08	1.2e-06	1.2e-05	NA	3.0e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.5	2.3	3.6	-0.7	-0.7	1.9	1.6	-1.8	1.9
Bipolar Disorder or Schizophrenia	2.3	5.6	12.1	-0.4	-0.6	3.0	3.5	-2.5	2.4
Depressed Affect (Nagel 2018)	0.4	0.8	3.6	-0.5	-0.6	0.3	-1.9	0.4	-0.2
Depression (Nagel 2018)	0.1	0.1	0.2	-0.2	-0.0	0.3	-0.5	0.5	-0.4
Intelligence (Savage-Jansen 2018)	3.2	9.8	17.7	1.1	1.6	-3.2	-3.6	3.8	-4.2
Neuroticism (Nagel 2018)	0.9	2.2	6.7	-1.5	-1.8	-0.6	-2.6	0.6	-0.5
Schizophrenia (2018)	1.7	3.6	10.2	0.1	-0.2	2.4	3.2	-1.7	1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	0.7	0.3	-0.1	1.2	-0.7	0.5
Worry (Nagel 2018)	0.7	1.4	3.2	-1.4	-1.8	0.2	-1.7	-0.2	0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	-0.4	-0.6	0.9	0.2	0.1	-0.1
Alzheimer’s Disease (in father)	1.8	1.9	4.1	0.3	0.5	0.6	2.0	-2.0	1.7
Alzheimer’s Disease (including proxy)	0.4	0.6	2.6	-0.6	-0.7	0.2	1.6	-0.6	0.2
Crohns Disease (2017)	0.6	1.3	3.5	-1.1	-0.9	-0.5	-1.9	1.1	-1.0
Irritable Bowel Disease (IBD)	1.4	3.3	10.6	-0.3	-0.0	-3.3	-1.7	1.2	-2.1
Ulcerative Colitis (UC)	3.1	5.8	23.0	0.3	0.6	-4.8	-1.5	1.2	-2.7
Major Depression (MDD)	0.9	1.1	1.7	0.8	1.1	1.3	0.2	-1.2	1.2
Reaction Time	0.8	1.5	3.8	-1.2	-0.8	1.4	1.9	1.1	-0.4
Verbal and Numeric Reasoning (VNR)	1.9	4.6	7.7	1.3	1.6	-2.3	-2.1	2.5	-2.8
Breast Cancer	0.2	0.5	1.0	-0.1	0.5	0.7	0.4	-1.0	1.0
Ovarian Cancer	0.4	0.5	0.9	-1.0	-0.8	0.6	-0.8	0.6	-0.0
Prostate Cancer	1.8	2.5	3.6	-1.1	-0.8	-1.6	-1.9	1.9	-1.8
Age at First Birth	0.0	0.0	0.1	-0.2	0.0	-0.4	-0.3	0.0	-0.1
Bipolar Disorder (2011)	0.8	0.8	3.4	-0.6	-0.1	0.4	1.9	-0.9	0.5
Body Mass Index (BMI) (2010)	1.1	1.6	4.2	-1.0	-0.4	-0.3	0.5	2.1	-1.9
Coronary Artery Disease (CAD)	1.0	1.2	3.6	-0.4	-0.8	-0.1	-1.9	1.3	-1.1
Crohns Disease (2012)	1.1	1.8	4.0	0.1	0.8	0.1	-1.8	2.0	-1.7
Mean Putamen Volume	2.4	2.7	5.2	-1.7	-2.3	2.2	-0.9	-0.8	1.5
Fasting Glucose	0.6	0.7	1.8	1.3	1.3	-0.7	0.4	-0.1	0.0
HbA1C	0.9	1.0	1.9	-0.8	-1.4	0.5	1.2	-0.6	1.2
HDL Cholesterol	0.2	0.3	0.5	0.6	0.7	0.3	-0.7	-0.4	0.1
LDL Cholesterol	0.2	0.3	0.9	-0.3	-0.5	-0.5	-0.1	-1.0	0.2
Lupus	2.2	3.4	8.2	-0.3	-0.3	2.9	0.9	-2.1	2.5
Neuroticism (2016)	1.3	1.9	5.8	0.4	0.4	-0.5	-2.4	1.8	-1.2
Primary Biliary Cirrhosis	2.6	3.7	8.6	-0.4	-0.6	1.8	-1.3	-2.8	2.9
Rheumatoid Arthritis	0.3	0.4	1.2	-1.0	-1.1	-0.3	0.5	-0.5	0.1
Schizophrenia (2014)	1.7	3.8	8.8	-0.6	-0.9	2.1	3.0	-2.2	1.9
Triglycerides	0.1	0.1	0.7	0.0	0.1	-0.8	-0.2	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.8	0.2	-0.0	-1.0	-1.0	2.2	-1.3
Ulcerative Colitis	3.1	4.5	17.6	0.5	0.7	-4.2	-1.0	1.1	-2.6
Blood Eosinophil Count	1.5	11.5	23.6	-3.6	-3.5	4.9	1.9	-2.2	3.4
Blood Platelet Count	0.2	2.4	4.8	0.6	2.0	-0.8	-0.7	2.2	-2.1
Blood Red Count	0.1	1.2	5.4	-0.3	0.0	-2.3	1.3	0.1	-0.5
Blood White Count	0.2	1.5	4.6	-1.6	-1.1	1.0	2.1	-0.2	-0.1
Heel T-Score	0.1	1.1	2.8	0.9	0.4	-1.7	-0.3	1.3	-1.1
BMI	0.7	4.3	11.8	1.8	1.8	0.2	3.4	2.1	-1.8
Height	0.9	17.4	46.5	-0.3	-1.0	2.7	3.0	-6.8	6.4
Waist Hip Ratio (WHR)	1.0	4.7	13.8	1.1	1.1	1.2	1.7	-3.7	2.7
Systolic Blood Pressure	0.4	2.0	7.1	-0.5	-1.1	1.1	-2.7	-0.9	1.3
Smoking Status	0.1	0.2	0.4	-0.6	-0.6	-0.3	0.4	0.1	-0.4
Allergy or Eczema	1.3	3.4	6.7	-1.5	-2.0	-1.0	-1.0	2.6	-2.4
Cardiovascular Disease	0.5	1.7	3.0	1.5	1.7	1.3	0.3	-1.3	1.4
Hypothyroidism (self reported)	1.8	4.2	11.7	1.8	1.8	3.4	2.5	-0.4	0.8
Respiratory disease	2.2	4.9	10.3	-3.1	-3.2	-0.6	-1.0	2.0	-1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	-0.2	-0.2	-1.2	-0.0	0.5	-0.7
Lung FEV1/FVC ratio	1.3	6.6	12.4	2.4	1.9	-2.2	-1.3	3.5	-3.3
Lung FVC	0.8	4.3	8.4	0.3	0.2	2.4	2.1	-2.6	2.9
Neuroticism	0.5	1.2	4.3	-0.4	-0.8	-0.8	-2.1	0.9	-0.8
Chronotype (morning person)	1.7	3.9	7.3	-2.1	-2.0	-1.2	-2.7	1.6	-1.8
Hair Pigment	0.1	3.8	6.6	-2.2	-2.5	-2.6	0.7	0.9	-2.0
Tanning	0.2	1.9	3.9	0.5	0.9	1.8	2.0	-1.1	1.5
Hand grip strength (left)	1.2	3.1	7.5	0.6	0.8	-1.5	1.4	2.4	-2.7
Number of treatments/medications taken	0.3	0.5	1.7	-0.3	-0.3	1.3	0.1	0.8	-0.4
Average weekly spirits intake	1.6	1.9	5.7	-1.0	-0.7	1.7	2.4	-0.9	1.0
Sensitivity / hurt feelings	0.6	0.9	2.5	-0.2	0.0	-0.3	-1.5	1.6	-0.9
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.9	-0.8	-0.4	-0.1	-1.0	1.7	-1.6
Hearing difficulty/problems: Yes	0.2	0.2	0.8	-0.3	-0.6	-0.9	0.4	-0.0	-0.2
Relative age of first facial hair	0.3	0.5	1.9	0.5	0.8	1.4	0.6	-0.1	0.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.8	-1.6	-1.7	0.4	-0.9	0.7	-1.0
Ever used hormone-replacement therapy (HRT)	1.2	1.5	7.3	-0.5	-0.9	-0.5	-2.7	0.3	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	0.3	0.1	1.2	-0.1	-1.2	1.4
Systolic blood pressure, automated reading	0.4	1.2	3.1	-1.4	-1.8	0.4	-1.1	-0.5	0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	3.5	1.8	1.9	0.8	-0.5	0.2	0.2
Angina	0.1	0.2	0.3	-0.5	-0.2	0.0	0.6	-0.5	0.5
Medication for hormone replacement therapy	0.8	0.9	1.5	1.2	1.0	-0.1	0.3	1.2	-1.1
Vitamin and mineral supplements	0.2	0.2	0.8	0.0	-0.4	0.1	0.9	-0.4	0.6
Supplements: Zinc	0.5	0.5	0.8	0.5	0.6	0.9	0.7	-0.7	0.8
Medication: Co-codamol	1.4	1.6	4.1	-2.0	-1.8	1.0	0.5	-0.5	0.9
Medication: Metformin	0.9	1.2	1.7	1.2	1.3	-1.2	0.6	1.1	-1.2
Diabetes (father)	0.3	0.3	0.5	-0.7	-0.6	0.7	0.1	-0.6	0.5
Diabetes (mother)	1.9	2.4	6.7	2.2	1.6	0.8	2.6	0.3	-0.2
Severe depression (siblings)	0.2	0.2	0.3	0.6	0.4	0.3	0.4	-0.4	0.5
Pack years adult smoking proportion	0.7	1.1	2.3	-1.5	-1.5	0.6	1.3	-0.0	0.4
Impedance of leg (right)	0.1	0.4	1.1	-0.8	-0.7	0.4	-1.0	-0.3	0.5
Leg fat-free mass (left)	0.5	2.6	9.1	0.7	0.5	1.1	3.0	-1.5	1.5
Trunk fat percentage	0.5	2.2	7.8	1.4	0.8	1.2	2.8	-0.7	0.9
Hand grip strength (right)	1.4	3.9	8.4	-0.2	0.2	-2.3	1.9	2.3	-2.9
Townsend deprivation index at recruitment	1.3	1.8	3.9	2.0	1.8	0.4	1.8	-0.3	0.0
Current tobacco smoking	0.4	0.6	1.6	0.5	1.1	0.6	1.2	-0.5	0.4
Average weekly fortified wine intake	0.5	0.6	1.0	0.6	0.4	0.9	-0.3	-1.0	1.0
Maternal smoking around birth	0.3	0.4	1.1	-1.0	-0.0	-1.0	-0.6	0.1	-0.5
Fed-up feelings	0.2	0.4	1.2	-1.1	-1.0	-0.1	-0.4	0.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.6	0.8	0.1	-0.8	0.7	-0.6
Relative age voice broke	0.6	0.9	1.7	0.2	1.0	0.9	-1.3	-1.1	0.9
Taking other prescription medications	1.1	1.7	3.6	-1.1	-1.3	1.9	1.6	-0.7	0.7
Age when periods started (menarche)	0.8	2.0	5.4	-2.2	-2.3	0.3	1.2	-0.0	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.8	-0.4	-0.6	1.4	-0.6	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.3	2.5	2.2	-0.8	1.6	1.5	-1.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	0.8	1.1	0.5	-0.9	-0.3	0.6
Qualifications: CSEs or equivalent	1.3	1.7	3.9	0.6	0.1	1.6	0.7	-1.7	2.0
Serious illness, injury or assault to yourself	0.8	1.0	3.3	-0.0	-0.2	0.6	-0.4	1.8	-1.4
High blood pressure	0.1	0.4	0.7	0.6	0.8	0.8	-0.2	0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.6	-1.2	-1.7	-0.8	-0.6	1.9	-1.8
Multivitamins +/- minerals	0.4	0.5	1.6	0.8	1.3	0.4	-0.7	0.3	-0.1
Stomach or abdominal pain in last month	1.8	2.2	5.9	1.1	0.7	2.4	1.7	-0.9	1.4
Supplements: Glucosamine	0.4	0.5	1.3	0.1	-0.1	0.7	-1.1	1.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-1.2	-0.9	0.5	-0.1	0.3	-0.2
Medication: Atenolol	0.9	1.1	2.6	0.7	0.4	1.1	-0.1	-1.5	1.6
Medication: Levothyroxine sodium	1.7	2.9	6.7	0.9	0.9	2.6	2.5	-1.2	1.3
Sitting height	0.1	0.7	1.3	-0.6	-1.0	0.9	0.7	1.1	-0.5
Chronic bronchitis/emphysema (father)	2.2	2.6	4.9	-0.5	-0.0	1.6	2.2	-1.8	2.1
High blood pressure (mother)	0.2	0.3	0.9	-0.6	-0.8	0.2	-0.9	0.1	0.2
Body mass index (BMI)	0.6	2.7	8.8	1.6	1.5	0.1	3.0	1.2	-1.0
Impedance of leg (left)	0.1	0.6	2.3	-0.5	-0.6	0.4	-1.5	-0.6	0.7
Leg predicted mass (left)	0.5	2.6	9.1	0.7	0.5	1.0	3.0	-1.6	1.5
Trunk fat mass	0.7	2.9	10.9	1.5	0.9	1.3	3.3	-1.0	1.1
Waist circumference	0.6	2.3	6.1	1.9	1.8	0.5	2.5	-0.8	0.6
Number of incorrect matches in round	0.8	1.4	3.2	1.3	1.8	0.3	0.9	-1.3	1.0
Past tobacco smoking	0.6	1.1	3.2	0.3	0.1	1.8	0.3	-0.9	1.5
Alcohol usually taken with meals	1.1	1.7	8.6	0.4	0.4	-1.1	-2.9	-0.2	0.1
Nervous feelings	0.7	1.3	4.1	-1.1	-1.6	0.2	-2.0	0.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.8	-0.1	-0.4	1.7	-1.4	-0.0	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.2	0.1	0.5	0.5	-0.1	0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	0.6	0.6	0.4	1.2	0.0	0.2
Had menopause	0.8	0.9	2.0	0.4	0.9	-1.4	-1.4	0.4	-0.8
Had other major operations	0.9	1.1	3.0	-0.1	0.1	1.7	-1.6	-0.8	0.6
Forced vital capacity (FVC)	0.8	2.9	6.9	-0.8	-0.7	1.6	0.5	-2.6	2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	1.8	1.1	0.7	-1.4	1.2	1.0	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.8	-0.4	-0.8	-0.4	1.1	-1.0
Qualifications: None of the above	0.9	2.0	5.3	-1.5	-1.2	-1.4	2.3	-1.0	0.3
Financial difficulties in last 2 years	0.9	1.2	2.2	0.7	0.5	1.1	1.1	-1.5	1.4
Mouth/teeth dental problems	1.4	2.1	6.4	2.2	2.5	0.4	-0.8	0.4	-0.0
Heart attack	0.8	1.0	2.4	-0.8	-1.3	1.0	1.5	0.6	-0.4
Allergy	1.1	2.6	5.2	1.3	1.6	1.1	0.6	-2.1	2.3
Pain all over the body in last month	2.9	3.1	9.5	-3.1	-2.9	0.1	0.7	0.0	-0.2
Diabetes (self-reported)	0.0	0.1	0.2	-0.1	0.2	-0.4	0.1	0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	3.2	-0.4	-0.4	-0.1	-0.3	1.8	-1.3
Medication: Ramipril	0.4	0.5	0.9	0.6	1.0	0.1	-0.9	0.6	-0.6
Medication: Simvastatin	0.8	1.2	2.4	1.2	1.4	-0.3	1.5	-0.9	0.3
Fluid intelligence score	2.3	4.8	8.8	1.0	1.0	-2.2	-2.3	2.8	-3.0
Illnesses of siblings	0.0	0.0	0.1	-0.0	-0.1	-0.2	-0.2	0.0	0.3
Neuroticism score	0.6	1.2	5.3	-0.4	-0.5	-0.4	-2.3	1.0	-0.8
Weight	0.5	2.3	10.1	1.3	1.0	0.6	3.2	-0.5	0.5
Impedance of arm (right)	0.5	2.2	5.2	-0.8	-0.9	1.2	-2.3	-1.3	1.8
Arm fat percentage (right)	0.6	2.4	9.1	1.5	1.3	0.9	3.0	0.6	-0.3
Trunk fat-free mass	0.5	2.6	10.1	1.2	1.2	0.6	3.2	-1.2	1.0
Hip circumference	0.3	1.5	3.0	1.7	1.7	-0.1	1.4	0.9	-0.6
Time employed in main current job	0.8	0.9	1.9	-0.3	-0.6	-1.2	0.1	1.4	-1.3
Alcohol intake versus 10 years previously	0.3	0.4	1.7	-0.7	-0.4	0.5	1.3	-0.1	0.1
Father’s age at death	1.8	2.4	5.3	1.6	0.8	-2.3	-1.8	0.5	-1.4
Worrier / anxious feelings	0.0	0.1	0.2	0.1	-0.2	0.5	0.2	0.5	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.3	1.4	1.5	1.1	-0.4	0.3	0.1
Falls in the last year	1.6	2.2	3.5	-1.2	-1.2	1.5	1.2	-1.8	1.9
Hair/balding pattern: Pattern 3	3.2	4.7	13.0	0.1	0.6	-1.9	0.7	3.3	-3.6
Number of live births	0.4	0.5	1.0	-0.1	0.1	1.0	1.0	-0.5	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.6	-0.8	-0.6	1.2	0.1	-1.0	1.3
Pulse rate	0.3	0.5	1.5	0.4	-0.3	0.4	0.1	1.2	-1.0
Happiness	0.8	1.0	3.0	1.7	1.7	-0.1	0.1	-0.2	-0.1
Noisy workplace	1.6	1.9	6.5	-0.4	-0.5	1.0	2.6	-1.4	1.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.7	0.4	0.3	1.3	-0.2	0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.0	0.4	0.7	-0.4	-1.2	1.4	-1.0
Mouth/teeth dental problems: Dentures	1.2	2.0	3.9	-1.4	-1.0	-1.0	2.0	1.4	-1.5
Asthma	1.6	3.2	4.9	-2.2	-2.2	-0.8	-0.8	2.0	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.2	-0.1	0.8	-0.1	0.8	-0.1
Medication: Cholesterol lowering	0.7	1.1	3.7	1.9	1.3	-0.9	0.4	0.1	-0.5
Depression (self-reported)	0.1	0.1	0.6	-0.1	-0.4	0.8	-0.3	0.2	0.2
Medication: Lansoprazole	1.1	1.2	2.2	0.9	1.2	1.4	1.5	-0.2	1.0
Prospective memory result	2.4	2.9	7.6	-0.4	-0.4	2.8	0.6	-1.9	2.4
Lung cancer (father)	0.2	0.2	0.6	0.7	0.3	-0.1	-0.8	-0.1	0.1
Illnesses of mother	0.4	0.5	1.2	1.1	1.1	0.2	0.5	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.4	-0.5	-0.2	1.0	-0.3	-1.0	1.2
Pulse wave Arterial Stiffness index	1.4	1.6	4.7	-1.1	-1.2	-0.8	0.2	-2.2	1.2
Impedance of arm (left)	0.7	3.2	4.6	-1.6	-1.8	1.1	-2.1	-1.8	2.1
Arm fat mass (right)	0.7	2.8	11.6	1.6	1.3	1.0	3.4	-0.1	0.3
Trunk predicted mass	0.4	2.6	9.5	1.2	1.2	0.7	3.1	-1.3	1.0
Standing height	0.5	5.0	14.7	-0.3	-0.7	1.3	1.1	-3.8	3.4
Length of working week for main job	0.2	0.2	0.6	-0.8	-0.3	-0.2	-0.2	-0.4	0.3
Exposure to tobacco smoke at home	2.7	3.1	7.8	-2.8	-2.7	0.5	1.7	0.6	-0.1
Breastfed as a baby	1.6	2.0	4.1	-0.9	-0.7	-0.6	-1.8	2.0	-1.7
Tense / ‘highly strung’	0.6	1.0	3.7	0.3	-0.1	-0.7	-1.9	1.1	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.3	0.7	0.8	-0.5	0.1	0.5
Hair/balding pattern: Pattern 4	0.4	1.1	1.7	1.1	1.0	-0.8	-1.0	1.1	-1.3
Birth weight of first child	0.3	0.5	1.2	-0.5	-0.4	-0.2	-1.0	-1.1	0.7
Peak expiratory flow (PEF)	0.4	0.9	2.7	-1.1	-0.7	-0.6	-1.6	0.5	-0.7
Pulse wave reflection index	2.4	2.9	6.3	-1.3	-0.9	0.4	2.2	-2.5	1.9
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.2	-1.8	-1.7	-0.6	-2.0	-0.5	0.4
Loud music exposure frequency	0.6	0.6	1.4	-1.0	-1.2	-0.9	-0.6	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.2	1.2	1.3	2.0	-0.5	0.7	0.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.6	-1.6	-1.6	0.5	-0.5	-1.6	1.5
Blood clot in the leg (DVT)	1.0	1.3	3.2	-0.6	-0.5	-0.8	-0.8	1.6	-1.8
Medication: Paracetamol	1.8	3.1	8.7	-1.2	-0.8	3.0	1.4	-1.3	2.0
Headache pain in last month	0.9	1.6	2.8	-1.6	-1.7	1.2	1.5	-0.3	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-0.9	-1.0	0.1	0.1	0.1	0.1
Glaucoma (self-reported)	1.4	1.6	5.0	-1.5	-1.2	-0.6	2.2	0.6	-0.6
Gout (self-reported)	0.6	0.8	1.7	1.3	1.1	0.6	1.1	0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	13.0	1.1	1.1	3.6	2.6	-1.4	1.9
Medication: Amlodipine	0.5	0.7	2.0	1.4	1.2	-0.5	-0.3	0.0	-0.1
Medication: Ventolin 100micrograms inhaler	1.8	2.2	4.2	-2.0	-2.0	-0.9	-1.0	1.2	-1.4
Birth weight	0.1	0.3	0.9	0.9	0.6	0.1	0.3	-0.5	0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	-1.0	-0.8	-1.1	-0.2	0.1	-0.4
High blood pressure (siblings)	0.4	0.6	1.6	-0.0	0.1	0.2	1.1	-1.3	0.9
Forced vital capacity (FVC), Best measure	0.6	2.1	4.9	-0.7	-0.3	1.6	0.3	-2.2	2.2
Body fat percentage	0.5	2.1	8.4	1.5	1.0	1.1	2.9	0.0	0.3
Leg fat percentage (right)	0.7	2.4	9.3	1.2	1.0	0.6	3.1	1.2	-0.9
Arm fat-free mass (right)	0.6	2.9	10.3	1.3	1.1	0.5	3.2	-1.6	1.2
Exposure to tobacco smoke outside home	0.2	0.2	0.6	0.1	-0.5	0.3	0.1	-0.7	0.8
Comparative body size at age 10	2.7	7.4	10.7	3.1	3.3	-2.6	-0.8	2.6	-3.1
Number of full brothers	1.5	1.9	4.5	-1.8	-2.1	-1.0	-0.1	1.1	-1.1
Worry too long after embarrassment	1.3	2.2	7.0	-0.6	-0.6	-1.9	-2.7	0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.9	-1.7	-1.7	-0.1	-0.2	-1.1	1.0
Wheeze or whistling in the chest in last year	0.3	0.5	2.0	-0.5	-0.4	-1.4	-0.0	0.2	-0.9
Number of children fathered	0.5	0.6	1.3	0.2	-0.0	-0.6	-1.2	1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.0	0.7	0.9	0.1	1.4	-1.4	1.0
Age at first live birth	1.1	2.0	4.3	2.1	1.9	-0.8	-1.6	0.5	-0.7
Pulse wave peak to peak time	1.2	1.4	3.8	1.2	1.2	0.9	-0.1	2.0	-1.0
Health satisfaction	2.5	3.2	5.5	0.7	0.5	1.9	2.4	-2.1	2.2
Shortness of breath walking on level ground	0.3	0.3	1.1	0.3	0.3	0.4	-0.2	-0.8	1.1
Qualifications: College or University degree	1.2	3.8	7.7	0.9	0.9	-1.1	-2.8	2.4	-2.5
Eye problems/disorders: None of the above	0.8	0.9	1.9	1.4	0.8	-1.0	-1.3	0.0	-0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.8	-0.0	-0.3	1.0	0.5	-1.7	1.4
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.3	-0.1	-0.6	-0.2	-0.8	0.5
Medication for pain relief, constipation, heartburn	0.3	0.6	2.0	0.1	0.2	-1.1	-1.4	0.0	-0.3
Neck or shoulder pain in last month	0.2	0.3	0.9	0.4	0.5	0.4	0.3	0.9	-0.5
Medication: Blood pressure	0.2	0.4	1.0	0.5	0.8	1.0	-0.4	0.4	-0.2
Angina (self-reported)	0.2	0.2	0.5	-0.7	-0.4	0.2	0.7	-0.4	0.5
Migraine (self-reported)	1.0	1.2	2.6	-1.2	-1.3	0.8	1.6	0.9	-0.2
Medication: Ibuprofen	0.2	0.3	0.6	0.4	0.3	0.5	0.7	0.8	-0.2
Medication: Allopurinol	0.7	0.9	1.5	1.2	0.9	0.6	0.6	1.2	-1.0
Medication: Omeprazole	0.7	0.8	2.2	-1.2	-1.5	0.6	0.9	0.3	-0.3
Medication: Seretide 50 evohaler	1.5	1.7	3.6	-0.5	-0.8	-1.5	-0.7	1.7	-1.9
Mean time to correctly identify matches	1.2	2.2	4.3	-1.5	-1.0	-0.5	1.4	2.1	-1.9
Heart disease (mother)	0.6	0.7	1.6	0.5	0.9	-0.7	-0.4	1.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.0	-0.7	-0.8	-0.4	0.4	1.7	-1.7
Whole body fat mass	0.8	3.2	11.2	1.6	1.2	1.5	3.4	-0.6	0.9
Leg fat mass (right)	0.7	2.5	11.6	1.2	0.9	1.2	3.4	0.1	0.3
Arm predicted mass (right)	0.6	2.9	8.8	1.3	1.0	0.2	3.0	-2.0	1.3
Pulse rate, automated reading	0.3	0.9	2.5	-0.4	-0.5	1.6	-0.1	1.4	-0.8
Alcohol intake frequency.	0.3	0.7	2.3	-0.2	-0.2	1.5	0.9	1.1	-0.1
Comparative height size at age 10	0.3	1.4	5.2	0.3	-0.0	-0.0	0.2	-2.3	1.7
Number of full sisters	0.3	0.4	1.9	-0.2	-0.1	-1.4	-0.5	0.1	-0.6
Suffer from ‘nerves’	1.6	2.5	10.2	-1.2	-1.8	-0.5	-3.2	-0.1	0.3
Overall health rating	0.4	0.9	3.1	0.2	-0.4	1.4	1.8	-0.2	0.4
Chest pain or discomfort	1.1	1.6	6.8	0.1	0.4	-0.7	-2.6	1.0	-1.2
Had major operations	1.0	1.2	3.0	0.8	1.2	1.4	1.7	0.2	0.1
Age at last live birth	0.5	0.7	1.5	0.7	0.4	-1.0	-1.2	0.8	-0.8
Family relationship satisfaction	0.6	0.7	1.6	0.2	-0.1	-1.0	-0.3	1.2	-1.2
Leg pain on walking	1.2	1.4	2.9	0.3	-0.2	1.7	0.9	-1.5	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.8	-1.3	-1.1	0.7	-1.3	-0.6	1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	1.1	0.8	-0.4	0.5	0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.9	-0.5	-1.1	0.6	1.7	-1.7	1.7
Medication: Aspirin	1.4	1.8	3.8	1.9	1.9	-1.1	0.3	0.9	-1.2
Supplements: Vitamin C	2.0	2.4	4.0	-2.0	-1.9	-1.3	-0.7	1.4	-1.7
Knee pain experienced in last month	0.2	0.3	1.4	-0.4	-0.2	1.2	-0.2	0.0	0.6
Hypertension (Self-reported)	0.1	0.3	1.3	0.3	0.7	1.1	0.0	0.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.8	-0.5	0.2	1.4	-0.2	0.2	0.3
Illnesses of father: Heart disease	0.8	1.1	2.1	-1.4	-1.0	0.4	-1.5	0.8	-0.6
Illnesses of siblings: Diabetes	0.5	0.6	1.1	1.1	1.0	-0.4	0.2	0.9	-0.9
Smoking status: Previous	0.9	1.4	3.5	-0.8	-0.7	-1.9	-0.5	1.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.3	-0.4	-0.7	-0.4	0.5	-2.3	1.6
Whole body fat-free mass	0.5	3.0	10.6	1.1	1.0	0.8	3.3	-1.6	1.3
Leg fat-free mass (right)	0.4	2.4	6.2	0.7	0.4	1.0	2.5	-1.9	1.7
Arm fat percentage (left)	0.5	2.1	9.5	1.1	0.8	1.0	3.1	0.2	0.2
Average weekly red wine intake	0.8	1.2	3.3	1.8	1.3	-1.0	-0.7	0.4	-0.5
Handedness (chirality/laterality): Left-handed	1.8	2.1	4.5	1.6	1.8	-0.2	-2.1	1.1	-1.2
Mood swings	0.9	1.6	4.5	2.0	2.1	0.7	-0.5	0.1	0.3
Loneliness, isolation	2.2	3.1	12.2	-1.2	-0.7	0.5	-3.5	1.8	-1.0
Long-standing illness, disability or infirmity	0.5	0.8	2.5	-1.6	-1.0	0.4	-0.4	0.6	-0.6
Ever had bowel cancer screening	1.7	2.0	7.3	-0.1	-0.4	-1.3	-2.7	-1.6	0.4
Diabetes diagnosed by doctor	0.3	0.4	0.9	-0.1	-0.0	-1.0	-0.0	0.9	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.4	-0.6	-0.2	0.3	-1.6	0.4	-0.2
Friendships satisfaction	1.3	1.6	3.3	-1.6	-1.1	-1.8	0.2	0.7	-1.3
Qualifications: nursing, teaching	0.8	1.3	4.7	0.9	0.8	0.2	-2.2	0.9	-0.7
Commuting to job workplace: Walk	0.2	0.3	0.6	0.5	0.7	0.4	-0.7	-0.2	0.2
Eye problems/disorders: Cataract	1.6	1.8	5.4	-2.3	-1.8	1.1	0.4	-0.6	0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.4	-1.2	-1.1	0.8	0.8	-1.0	1.0
Medication for cholesterol	0.8	1.2	1.7	-0.9	-1.3	-1.2	-1.3	1.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	4.8	0.8	0.5	2.2	0.9	-1.0	1.4
Back pain experienced in last month	0.4	0.5	0.9	0.9	0.7	0.8	0.2	0.9	-0.6
Mineral and other dietary supplements	0.7	1.0	4.8	0.5	0.3	0.1	2.2	-0.8	0.5
Breast cancer (self-reported)	0.1	0.1	0.3	0.6	-0.0	0.5	-0.1	-0.2	0.3
Asthma (self-reported)	1.7	3.3	5.1	-2.1	-2.2	-0.6	-1.0	2.3	-2.1
Osteoporosis (self-reported)	0.9	1.1	2.4	0.3	0.2	-0.3	-1.3	1.6	-1.5
Osteoarthritis (self-reported)	0.1	0.2	0.7	-0.4	0.1	0.2	0.1	0.9	-0.3
Medication: Aspirin	0.8	1.1	2.6	1.5	1.6	-1.0	0.2	0.4	-0.7
Medication: Gliclazide	1.7	1.9	5.0	0.6	0.7	-1.3	-0.4	2.2	-2.0
Illnesses of father: None of the above (group 1)	1.9	2.3	5.7	1.1	1.0	-1.8	-2.4	1.1	-1.2
Smoking status: Current	0.4	0.6	1.5	0.5	1.1	0.4	1.2	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	-1.0	-1.0	0.4	-0.4	0.4	-0.2
Whole body water mass	0.5	3.1	10.8	1.2	1.1	0.7	3.3	-1.7	1.4
Leg predicted mass (right)	0.4	2.4	6.4	0.8	0.4	0.9	2.5	-1.9	1.7
Arm fat mass (left)	0.7	2.8	12.4	1.3	1.1	1.0	3.5	-0.4	0.6
Number of self-reported non-cancer illnesses	0.6	1.0	2.1	-1.1	-1.0	1.5	1.2	-0.2	0.5
Average weekly champagne plus white wine intake	2.2	3.0	9.4	2.7	3.1	0.7	-0.8	0.3	0.1
Miserableness	0.3	0.5	2.7	0.2	0.5	-0.1	-1.6	-0.1	0.2
Guilty feelings	1.1	1.7	5.3	-0.3	-0.3	-1.2	-2.3	1.3	-1.2
Wears glasses or contact lenses	1.4	1.6	2.6	0.9	0.6	-1.3	-1.6	1.5	-1.3
Ever taken oral contraceptive pill	0.5	0.6	1.1	-1.0	-0.4	-0.6	0.3	1.0	-1.0
Hearing aid user	0.5	0.6	1.6	1.3	0.6	0.1	-0.3	-0.7	0.9
Mother’s age at death	0.1	0.1	0.3	0.5	0.3	0.3	-0.3	-0.4	0.4
Financial situation satisfaction	0.4	0.4	2.1	-0.2	-0.0	-0.4	1.5	0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.3	-0.1	-0.1	0.1	0.6	-0.5
Commuting to job workplace: Public transport	1.0	1.2	3.4	-1.0	-1.1	1.8	0.9	-0.2	0.6
Eye problems/disorders: Glaucoma	0.9	1.0	2.6	-0.6	0.2	-0.7	1.6	1.2	-1.1
Medication: Blood pressure	0.5	0.9	1.5	1.2	1.2	-1.0	-0.8	-0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	1.3	1.4	0.8	-0.6	1.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.4	-1.0	-0.6	-0.3	-1.5	0.6	-0.5
High cholesterol (Self-reported)	1.9	3.4	7.1	1.5	1.6	0.4	2.0	-2.7	2.0
Medication: Bendroflumethiazide	0.4	0.6	1.3	0.8	0.6	-0.3	-0.7	0.9	-1.1
Medication: Paracetamol	1.0	1.5	4.1	-1.7	-1.1	2.0	0.6	0.0	0.6
Medication: Lisinopril	0.1	0.1	0.2	0.3	0.3	0.1	-0.4	0.2	-0.2
Medication: Atorvastatin	0.3	0.4	0.7	0.8	0.7	-0.4	0.2	-0.8	0.4
Illnesses of father: High blood pressure	1.6	1.9	3.5	-0.4	-0.6	1.9	1.6	-1.6	1.6
Alcohol drinker status: Never	0.6	0.7	2.2	0.9	0.7	0.5	-0.1	1.5	-0.8
Ever smoked	0.4	0.7	1.1	0.6	0.8	-1.0	-0.9	0.7	-1.1
Basal metabolic rate	0.6	3.1	11.8	1.2	1.0	0.8	3.4	-1.4	1.2
Leg fat percentage (left)	0.6	2.1	7.1	1.4	1.2	0.6	2.7	1.1	-0.8
Arm fat-free mass (left)	0.6	3.1	10.4	1.8	1.7	0.3	3.2	-1.2	0.8
Number of operations (self-reported)	1.3	2.0	4.7	0.7	1.0	2.2	-2.0	-0.9	1.0
Average weekly beer plus cider intake	0.2	0.3	1.1	0.0	0.0	1.1	0.8	-0.3	0.5
Irritability	0.2	0.3	1.1	-0.4	-0.5	-0.1	-1.0	-0.1	0.2
Risk taking	1.1	1.6	2.8	0.6	0.6	1.7	-1.2	-1.4	1.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.3	-1.3	-1.5	-0.0	-0.3	1.5	-1.2
Fractured/broken bones in last 5 years	0.2	0.3	0.9	-1.0	-0.5	0.6	-0.2	0.5	-0.2
Age started oral contraceptive pill	0.6	0.8	1.7	-0.9	-1.3	-0.6	-1.3	-0.2	0.1
Diastolic blood pressure, automated reading	0.4	1.3	2.4	-1.2	-1.2	1.6	0.4	-0.9	1.2
Ever depressed for a whole week	0.4	0.5	1.0	-0.7	-0.0	-1.0	-0.0	0.8	-1.0
Unable to work because of sickness or disability	1.7	2.2	5.4	-2.3	-1.8	1.0	1.9	0.0	-0.1
Commuting to job workplace: Cycle	1.1	1.4	4.5	2.1	1.9	0.2	0.1	0.3	-0.2
Myopia	0.2	0.3	0.9	-0.3	-0.4	0.4	0.3	-0.9	0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.4	-0.5	-0.7	-0.0	-0.5	0.3
Cholesterol lowering medication	0.9	1.4	3.1	0.4	1.2	1.0	1.8	-1.2	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.7	-1.0	0.3	0.9	0.2	-0.2
Pain experienced in last month	0.7	1.2	3.5	-0.5	-0.3	-1.9	-1.5	0.5	-1.0
Supplements: Calcium	2.0	2.2	5.2	-0.0	-0.1	-0.3	-1.7	2.3	-2.2
Basal cell carcinoma (self-reported)	1.9	2.2	4.9	2.1	2.2	1.0	0.1	-1.1	1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.3	-1.0	-1.4	1.0	1.5	0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.4	-0.5	-0.8	-0.6	-0.6	1.7	-1.8
Heart disease (siblings)	0.5	0.6	2.0	-0.3	-0.1	0.1	-0.5	1.4	-1.1
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.3	-0.1	0.6	0.2	0.2	0.6
Pack years of smoking	0.6	0.9	2.2	-1.5	-1.5	0.4	0.9	0.1	0.3
Impedance of whole body	0.5	2.3	4.6	-1.1	-1.4	1.0	-2.1	-1.5	1.8
Leg fat mass (left)	0.6	2.5	10.4	1.4	1.0	1.2	3.2	-0.1	0.4
Arm predicted mass (left)	0.6	3.1	10.4	1.7	1.8	0.3	3.2	-1.3	0.8