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chr1:152,817,053-157,406,190

Best TWAS P=8.96e-35 · Best GWAS P=5.69e-29 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADAR	0.12	0.13	lasso	4	0.13	3.0e-15	5.044	-5.9	4.3e-09	-0.02	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MRPL24	0.05	0.01	enet	10	0.03	2.9e-04	6.138	-6.4	1.4e-10	-0.01	0.27	0.26	TRUE
3	GTEx	Adipose Subcutaneous	RP1-178F15.4	0.20	0.21	enet	16	0.25	2.3e-20	-4.992	-5.2	1.6e-07	-0.04	0.30	0.70	FALSE
4	GTEx	Artery Aorta	RP1-178F15.4	0.16	0.17	lasso	9	0.19	6.0e-11	-4.992	-5.2	1.8e-07	-0.05	0.35	0.65	FALSE
5	GTEx	Artery Tibial	MEF2D	0.17	0.10	enet	17	0.09	2.6e-07	5.790	6.0	1.6e-09	0.06	0.18	0.82	FALSE
6	GTEx	Artery Tibial	S100A13	0.14	0.04	lasso	8	0.08	1.2e-06	-5.028	-5.4	5.3e-08	-0.07	0.34	0.61	FALSE
7	GTEx	Artery Tibial	RP1-178F15.5	0.14	0.04	lasso	8	0.06	1.7e-05	-5.028	-5.5	3.4e-08	-0.06	0.30	0.53	FALSE
8	GTEx	Brain Caudate basal ganglia	S100A13	0.14	0.08	lasso	3	0.02	9.2e-02	-4.948	5.9	4.6e-09	0.05	0.04	0.80	FALSE
9	GTEx	Brain Cerebellar Hemisphere	DCST2	0.45	0.10	lasso	6	0.16	6.6e-05	-2.416	7.7	1.9e-14	0.75	0.01	0.96	FALSE
10	GTEx	Brain Frontal Cortex BA9	S100A13	0.21	0.04	enet	13	0.12	3.9e-04	-4.920	5.2	2.6e-07	0.00	0.11	0.40	FALSE
11	GTEx	Brain Frontal Cortex BA9	RP1-178F15.5	0.21	0.06	enet	13	0.16	4.7e-05	-5.194	5.2	2.7e-07	0.00	0.12	0.38	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	DCST2	0.28	0.04	lasso	5	0.13	2.0e-04	11.171	6.5	7.6e-11	0.69	0.02	0.90	TRUE
13	GTEx	Breast Mammary Tissue	S100A14	0.14	0.04	enet	17	0.05	2.0e-03	-5.016	-5.5	4.4e-08	-0.03	0.27	0.61	FALSE
14	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	-6.531	6.5	7.3e-11	0.09	0.04	0.07	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	S100A13	0.19	0.19	lasso	6	0.19	6.2e-07	-5.194	-5.2	1.5e-07	-0.04	0.22	0.74	FALSE
16	GTEx	Esophagus Mucosa	ADAM15	0.11	0.02	enet	16	0.04	1.5e-03	-4.739	-7.3	3.3e-13	-0.43	0.13	0.78	FALSE
17	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	-6.709	-6.3	2.4e-10	-0.12	1.00	0.00	FALSE
18	GTEx	Esophagus Mucosa	RP1-178F15.4	0.10	0.12	lasso	6	0.11	6.1e-08	-4.992	-5.2	1.5e-07	-0.04	0.31	0.68	FALSE
19	GTEx	Heart Atrial Appendage	RP1-178F15.4	0.25	0.25	enet	27	0.26	7.4e-12	-4.990	-5.1	2.9e-07	-0.05	0.35	0.65	FALSE
20	GTEx	Heart Left Ventricle	S100A14	0.10	0.07	lasso	3	0.05	7.1e-04	-5.194	5.4	7.7e-08	0.02	0.15	0.64	FALSE
21	GTEx	Liver	S100A13	0.23	0.06	enet	60	0.05	1.3e-02	5.837	6.0	1.5e-09	0.02	0.03	0.78	TRUE
22	GTEx	Liver	RP1-178F15.4	0.16	0.20	lasso	3	0.17	1.7e-05	-5.031	-5.2	1.9e-07	-0.05	0.22	0.63	FALSE
23	GTEx	Nerve Tibial	S100A16	0.09	0.08	lasso	4	0.09	4.2e-07	4.366	-5.1	3.0e-07	-0.07	0.34	0.65	FALSE
24	GTEx	Pancreas	RRNAD1	0.22	0.05	enet	25	0.03	2.7e-02	4.062	6.2	4.9e-10	-0.03	0.03	0.72	FALSE
25	GTEx	Pancreas	MRPL24	0.19	0.01	enet	16	0.01	1.6e-01	4.389	6.7	2.1e-11	-0.03	0.03	0.58	TRUE
26	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	2.000	-5.1	2.8e-07	-0.34	0.18	0.54	FALSE
27	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	2.000	-7.5	4.6e-14	-0.43	0.06	0.49	FALSE
28	GTEx	Pancreas	RP1-178F15.4	0.27	0.02	enet	22	0.12	8.9e-06	-4.770	-5.3	1.2e-07	-0.02	0.22	0.44	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	-6.722	5.3	9.5e-08	0.11	0.54	0.04	FALSE
30	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	11.171	-12.3	9.0e-35	-0.96	0.00	1.00	TRUE
31	GTEx	Skin Sun Exposed Lower leg	RP1-178F15.5	0.10	0.06	lasso	12	0.05	2.4e-05	-5.016	-5.6	1.8e-08	-0.03	0.34	0.65	FALSE
32	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	-5.582	-5.8	5.0e-09	-0.15	0.14	0.05	FALSE
33	GTEx	Stomach	RP1-178F15.4	0.29	0.10	enet	22	0.17	1.3e-08	-4.720	-5.3	1.0e-07	-0.04	0.39	0.60	FALSE
34	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	-6.722	-7.0	2.1e-12	-0.11	0.27	0.05	TRUE
35	GTEx	Thyroid	RP1-178F15.4	0.13	0.03	lasso	4	0.04	6.8e-04	-5.016	-5.1	2.8e-07	-0.05	0.34	0.65	FALSE
36	METSIM	Adipose	S100A5	0.05	0.00	blup	422	0.02	6.5e-04	-0.064	-5.4	5.9e-08	0.04	0.10	0.07	FALSE
37	NTR	Blood	ZBTB7B	0.02	0.02	lasso	1	0.01	5.4e-05	6.399	6.4	1.6e-10	0.67	0.87	0.03	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	SLC50A1	0.06	0.02	bslmm	331	0.03	4.3e-05	-6.709	-7.0	1.8e-12	-0.27	0.65	0.04	FALSE
39	YFS	Blood	ADAR	0.04	0.05	enet	14	0.05	4.3e-17	-7.424	8.6	8.1e-18	0.03	1.00	0.00	TRUE
40	YFS	Blood	LMNA	0.05	0.04	enet	8	0.05	1.1e-14	6.294	7.2	4.1e-13	-0.04	0.45	0.55	TRUE
41	YFS	Blood	MRPL24	0.08	0.03	enet	18	0.04	4.3e-12	4.627	-6.3	2.4e-10	-0.01	1.00	0.00	FALSE
42	YFS	Blood	MSTO1	0.13	0.08	blup	282	0.10	1.9e-29	6.264	-6.6	3.5e-11	-0.02	0.99	0.01	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	S100A16	0.03	0.02	blup	34	0.03	2.6e-03	-4.948	-5.2	1.7e-07	-0.05	0.02	0.86	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	S100A1	0.07	0.14	lasso	6	0.13	3.6e-11	-4.948	-5.2	2.6e-07	-0.04	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	-6.709	-5.5	4.3e-08	-0.11	0.02	0.34	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEMA4A	0.01	0.00	blup	51	0.01	1.2e-02	3.243	7.2	5.0e-13	-0.05	0.01	0.16	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	LMNA	0.07	0.00	blup	55	0.01	9.1e-02	2.773	5.6	2.4e-08	0.04	0.02	0.06	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	S100A13	0.09	0.05	blup	35	0.03	3.6e-02	-4.948	5.2	2.5e-07	0.05	0.02	0.68	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAG1AP1	0.07	0.00	blup	76	0.00	2.9e-01	-2.844	-6.8	7.6e-12	-0.17	0.02	0.13	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1orf77	0.02	0.02	blup	38	0.02	1.3e-03	4.557	5.1	2.8e-07	0.04	0.02	0.80	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB7B	0.05	0.06	lasso	2	0.05	1.8e-06	11.171	-11.2	5.5e-29	-1.00	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	GBA	0.05	0.01	lasso	2	0.01	2.3e-02	6.989	-5.8	5.8e-09	-0.07	0.00	0.76	TRUE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBQLN4	0.11	0.00	blup	33	0.04	3.8e-05	5.516	-5.8	8.7e-09	-0.01	0.00	0.97	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	S100A13	0.03	0.01	blup	35	0.03	3.8e-03	4.990	5.1	2.8e-07	0.05	0.02	0.73	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PMF1	0.17	0.10	blup	62	0.08	6.5e-04	3.728	-5.7	1.2e-08	0.07	0.01	0.44	TRUE