Hub : Genes

TACC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.094	0.0330	1.4e-03	0.035	0.024	0.038	0.052	0.055	3.6e-05	0.00056	1.9e-05	5.3e-07	3.0e-07
2	GTEx	Artery Tibial	0.331	0.0663	2.2e-06	0.312	NA	0.300	NA	0.305	6.4e-25	NA	8.1e-24	NA	2.8e-24
3	GTEx	Pancreas	0.217	0.0730	2.7e-03	0.018	NA	0.014	NA	0.042	5.5e-02	NA	8.3e-02	NA	7.2e-03
4	GTEx	Skin Not Sun Exposed Suprapubic	0.247	0.0790	3.3e-03	0.094	NA	0.098	NA	0.112	7.6e-06	NA	4.8e-06	NA	1.0e-06
5	GTEx	Skin Sun Exposed Lower leg	0.275	0.0570	6.1e-06	0.123	NA	0.163	NA	0.146	2.3e-10	NA	1.8e-13	NA	3.8e-12
6	TCGA	Bladder Urothelial Carcinoma	0.057	0.0260	8.6e-03	0.045	0.025	0.053	NA	0.025	1.0e-04	0.00290	2.5e-05	NA	2.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.2	0.8	0.1	-0.3	0.3	-0.4	-0.3	-0.9
Bipolar Disorder or Schizophrenia	0.3	0.7	2.1	0.5	-1.2	-0.5	0.1	0.2	-1.4
Depressed Affect (Nagel 2018)	1.3	2.8	11.1	-0.0	-1.1	1.2	1.1	1.4	3.3
Depression (Nagel 2018)	1.1	1.7	5.7	1.3	1.2	0.9	-0.5	0.4	2.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.3	0.1	-0.2	-1.2	0.7	1.2	-1.5
Neuroticism (Nagel 2018)	0.8	1.9	8.8	-0.1	-0.0	1.5	-0.7	-0.0	3.0
Schizophrenia (2018)	0.4	0.8	1.8	0.6	-1.4	-0.9	0.4	0.5	-1.1
Schizophrenia vs Biploar Disorder	0.9	1.1	1.9	-0.8	1.2	0.5	-1.2	-1.4	-1.1
Worry (Nagel 2018)	1.7	3.6	9.8	-1.0	0.7	1.8	-2.0	-1.6	3.1
Alzheimer’s Disease (in mother)	0.9	1.0	2.7	-1.5	-0.4	1.6	0.1	0.1	-1.0
Alzheimer’s Disease (in father)	1.2	1.3	3.8	-1.2	-1.9	0.2	-0.3	-0.1	-1.5
Alzheimer’s Disease (including proxy)	1.6	2.3	7.6	-1.4	-1.4	2.8	0.4	0.6	-1.2
Crohns Disease (2017)	1.2	2.6	5.5	-1.7	2.4	1.6	-1.3	-1.3	-1.0
Irritable Bowel Disease (IBD)	1.3	3.2	7.2	-2.7	1.7	0.6	-1.4	-1.7	-2.0
Ulcerative Colitis (UC)	1.4	2.7	7.8	-2.8	0.1	-0.5	-0.7	-1.1	-2.5
Major Depression (MDD)	0.6	0.7	2.0	0.1	0.5	1.4	0.0	0.0	-1.4
Reaction Time	0.8	1.5	3.8	0.3	-1.1	1.6	0.7	0.9	-1.9
Verbal and Numeric Reasoning (VNR)	0.9	2.0	5.6	0.4	0.5	-2.4	1.5	2.0	-0.3
Breast Cancer	3.3	7.9	18.7	4.2	2.6	0.9	-4.3	-0.8	-1.7
Ovarian Cancer	1.8	2.4	5.1	-1.5	-2.2	0.3	1.1	0.7	2.3
Prostate Cancer	0.3	0.5	1.4	0.2	0.2	1.2	-0.3	0.4	-1.1
Age at First Birth	1.2	1.7	3.3	-0.4	-0.6	-1.4	1.8	1.6	1.5
Bipolar Disorder (2011)	0.5	0.5	1.3	0.1	-0.2	1.1	-0.1	-0.5	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.5	0.8	0.8	0.3	0.9	1.6	-0.2
Coronary Artery Disease (CAD)	2.3	2.8	4.4	-1.9	-0.6	-0.1	-2.0	-2.1	-2.0
Crohns Disease (2012)	1.2	2.0	6.6	-1.5	0.9	2.6	-0.6	-1.3	-0.5
Mean Putamen Volume	0.3	0.4	1.2	0.5	0.3	1.1	0.3	-0.7	-0.4
Fasting Glucose	0.9	1.1	1.8	0.4	-0.8	-1.3	1.2	0.9	-1.3
HbA1C	0.8	0.9	2.4	0.5	0.7	1.6	-0.0	0.4	-1.3
HDL Cholesterol	1.2	2.0	4.8	-0.9	0.8	-0.1	-1.5	-2.2	-1.9
LDL Cholesterol	1.4	2.2	6.3	-0.8	-0.3	1.1	2.1	2.5	0.8
Lupus	0.6	0.9	4.2	0.7	-0.4	-2.1	0.4	-0.3	0.1
Neuroticism (2016)	0.9	1.2	3.9	2.0	-0.9	1.3	0.5	0.5	0.6
Primary Biliary Cirrhosis	0.5	0.8	2.2	-1.5	0.1	0.7	-0.7	-0.7	-1.0
Rheumatoid Arthritis	0.6	0.9	3.7	0.3	-0.9	-1.9	0.4	-0.4	-0.5
Schizophrenia (2014)	0.3	0.6	3.0	0.2	0.4	-0.1	-0.5	-0.5	-1.7
Triglycerides	0.7	1.2	2.0	0.5	-0.9	0.7	1.4	1.4	1.3
Type 2 Diabetes (T2D) (2012)	1.4	1.7	6.0	0.1	-0.4	2.5	0.4	0.3	1.9
Ulcerative Colitis	0.6	0.9	2.9	-1.7	-0.2	-0.3	0.4	0.3	-1.3
Blood Eosinophil Count	0.2	1.2	3.0	0.5	-1.1	0.7	1.7	1.4	-0.6
Blood Platelet Count	0.1	1.2	4.0	-0.3	0.1	1.4	2.0	1.0	-0.6
Blood Red Count	0.1	1.0	2.9	1.3	-0.1	-0.1	1.7	1.2	-0.3
Blood White Count	0.4	3.2	6.1	-1.0	-1.6	2.4	2.5	1.8	-0.5
Heel T-Score	0.6	5.0	13.4	2.5	2.5	1.8	-0.4	-0.8	3.7
BMI	0.1	0.5	1.2	1.1	-0.5	0.2	0.8	1.0	0.1
Height	0.5	8.8	44.1	2.2	-1.2	-6.6	-0.8	-1.3	0.6
Waist Hip Ratio (WHR)	0.3	1.5	4.5	-1.2	-2.1	1.0	-1.1	-0.8	0.0
Systolic Blood Pressure	0.3	1.3	4.0	-2.0	1.1	1.1	-0.5	-0.4	-0.9
Smoking Status	0.4	0.9	4.7	0.0	2.2	0.7	0.1	0.2	0.3
Allergy or Eczema	0.4	1.0	5.2	0.1	0.2	-0.6	0.0	-0.7	-2.3
Cardiovascular Disease	0.6	1.9	6.0	-0.4	-0.5	2.5	-1.2	-0.9	-1.6
Hypothyroidism (self reported)	1.5	3.5	8.2	0.2	-2.3	-2.5	-0.9	-0.1	-2.9
Respiratory disease	1.7	3.8	10.0	0.6	1.4	-2.7	-1.2	-1.2	-3.2
Type 2 Diabetes (T2D) (2018)	0.8	1.6	8.9	0.0	-3.0	0.5	0.3	-0.1	0.2
Lung FEV1/FVC ratio	1.8	9.0	22.9	-1.7	-0.2	1.2	3.8	3.6	4.8
Lung FVC	0.4	2.2	5.0	-1.5	-2.2	0.1	1.8	1.3	-0.8
Neuroticism	0.7	1.6	3.3	0.0	-0.6	1.7	-1.4	-1.0	1.8
Chronotype (morning person)	0.5	1.3	5.5	2.3	-0.4	-0.7	0.5	0.5	-1.0
Hair Pigment	0.1	2.9	7.6	-1.0	0.7	-0.8	-2.6	-2.8	-0.7
Tanning	0.2	1.9	5.0	0.5	-0.5	0.0	2.2	2.2	1.1
Hand grip strength (left)	0.4	0.9	3.4	-1.8	-1.2	0.2	0.0	-0.1	-0.8
Number of treatments/medications taken	0.9	1.7	6.7	0.6	-2.6	-0.0	-0.8	-0.9	-1.2
Average weekly spirits intake	1.0	1.3	2.5	-0.3	1.6	1.5	-1.1	-0.4	1.2
Sensitivity / hurt feelings	0.3	0.4	1.6	-0.0	0.7	1.3	-0.4	0.3	-0.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.3	0.2	1.7	1.2	-0.5	0.2	2.1
Hearing difficulty/problems: Yes	1.1	1.7	3.1	0.8	-1.8	1.4	-1.5	-0.9	-1.2
Relative age of first facial hair	1.9	3.9	14.8	2.2	1.7	-3.8	0.2	-0.4	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	0.5	-1.0	0.8	-1.0	-0.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.9	1.7	-0.4	-0.1	1.0	1.0	-1.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	0.9	-0.3	-0.0	0.5	1.1	-0.5
Systolic blood pressure, automated reading	0.3	0.8	2.5	-1.5	1.6	-0.2	-0.3	-0.4	-0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	4.1	-0.6	-0.6	2.0	-1.0	-0.8	0.2
Angina	1.2	1.6	4.5	-0.2	-2.1	1.0	0.6	0.2	-1.9
Medication for hormone replacement therapy	1.3	1.5	4.2	1.0	-1.0	2.0	0.9	1.0	-1.0
Vitamin and mineral supplements	0.4	0.5	1.6	0.1	0.2	0.2	1.0	1.3	-0.2
Supplements: Zinc	1.7	1.8	5.4	-0.5	0.0	1.0	-2.3	-2.1	-0.1
Medication: Co-codamol	1.8	2.1	4.4	-0.1	-1.2	-2.1	-1.6	-1.4	1.5
Medication: Metformin	2.5	3.5	17.5	-0.1	-4.2	0.5	1.2	1.2	0.7
Diabetes (father)	0.5	0.6	2.0	-0.2	0.9	0.5	-0.6	0.0	1.4
Diabetes (mother)	0.7	0.8	2.2	-0.7	-1.2	1.5	-0.2	0.0	0.8
Severe depression (siblings)	1.3	1.5	5.5	1.3	0.3	-0.1	-1.0	-0.9	2.3
Pack years adult smoking proportion	1.0	1.6	3.3	1.8	-1.4	0.3	0.9	1.5	0.9
Impedance of leg (right)	0.3	1.3	4.6	2.2	0.9	1.3	-0.4	-0.7	-0.3
Leg fat-free mass (left)	0.1	0.8	3.6	-0.2	-1.0	-1.9	0.1	0.2	0.1
Trunk fat percentage	0.5	2.0	5.5	2.3	0.2	-0.8	1.6	1.1	-1.3
Hand grip strength (right)	0.5	1.3	5.1	-2.2	-0.3	-0.8	-1.2	-0.9	-0.1
Townsend deprivation index at recruitment	0.3	0.5	1.0	1.0	-0.7	-0.8	-0.4	-0.2	-0.6
Current tobacco smoking	0.6	1.0	3.6	1.0	1.9	1.0	-0.1	-0.1	0.5
Average weekly fortified wine intake	0.3	0.3	1.2	-0.2	-0.5	-0.2	0.6	0.3	1.1
Maternal smoking around birth	0.5	0.8	2.0	1.4	-0.3	-0.2	1.2	1.0	0.0
Fed-up feelings	0.7	1.3	7.1	0.0	-0.3	0.7	-0.5	0.2	2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	5.3	0.7	-0.1	0.9	-1.1	-0.3	2.3
Relative age voice broke	1.1	1.7	5.7	1.3	1.6	-2.4	0.0	-0.3	-0.2
Taking other prescription medications	1.4	2.1	8.2	-0.3	-2.0	-0.6	0.1	-0.6	-2.9
Age when periods started (menarche)	0.6	1.5	3.2	1.8	1.2	-1.1	0.7	0.9	1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.7	-0.9	0.2	0.2	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.5	-1.3	2.1	0.8	-1.6	-1.5	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.4	0.1	-0.7	1.5	0.0	-0.1	-1.0
Qualifications: CSEs or equivalent	1.0	1.3	4.1	-0.1	1.1	-0.3	-1.3	-2.0	0.8
Serious illness, injury or assault to yourself	0.4	0.5	2.2	0.4	-0.3	0.0	-0.7	-1.5	-0.4
High blood pressure	0.3	0.7	4.0	0.1	-0.2	2.0	-0.3	0.2	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.9	0.4	0.1	-0.3	-0.0	-0.8	-1.7
Multivitamins +/- minerals	0.4	0.5	0.9	-0.9	-0.7	0.1	-0.8	-0.9	0.4
Stomach or abdominal pain in last month	0.8	1.0	4.2	-1.0	0.3	2.0	-0.3	-0.4	0.5
Supplements: Glucosamine	0.2	0.3	1.4	-0.3	-0.3	-0.3	-0.3	-0.3	1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	6.0	-1.8	0.3	2.5	-0.1	-0.1	-1.4
Medication: Atenolol	0.5	0.6	1.2	0.8	0.2	0.4	0.8	1.1	-0.9
Medication: Levothyroxine sodium	0.4	0.8	3.6	0.3	-0.5	-0.7	-0.0	0.3	-1.9
Sitting height	0.3	1.8	4.7	-0.9	-1.2	-1.8	0.7	0.3	2.2
Chronic bronchitis/emphysema (father)	3.1	3.6	8.7	1.2	0.5	-2.0	-2.7	-2.9	0.1
High blood pressure (mother)	0.3	0.4	1.5	0.1	0.5	1.2	-0.0	0.6	-0.4
Body mass index (BMI)	0.1	0.4	0.8	0.3	-0.8	0.5	0.8	0.9	-0.0
Impedance of leg (left)	0.2	1.0	3.5	1.9	1.2	0.8	0.1	-0.4	-0.4
Leg predicted mass (left)	0.1	0.7	3.2	-0.3	-1.0	-1.8	0.0	0.2	0.1
Trunk fat mass	0.3	1.2	3.3	1.8	-0.2	-1.1	1.2	0.7	-0.8
Waist circumference	0.1	0.3	0.7	0.6	-0.8	-0.4	0.3	0.3	-0.4
Number of incorrect matches in round	0.6	1.0	2.4	0.2	1.5	1.6	-0.1	-0.4	1.0
Past tobacco smoking	0.0	0.0	0.1	0.3	-0.3	0.1	-0.0	-0.1	0.1
Alcohol usually taken with meals	0.7	1.1	3.4	-0.5	-1.4	-1.9	0.3	0.1	-1.1
Nervous feelings	0.8	1.5	2.2	-1.2	1.4	1.0	-1.3	-1.5	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.4	-2.0	-0.0	2.1	-1.4	-0.5	1.9
Hearing difficulty/problems with background noise	1.0	1.5	5.6	0.4	0.6	2.4	-1.3	-0.6	-1.1
Hair/balding pattern: Pattern 2	1.0	1.3	3.0	0.2	0.3	-1.7	-1.3	-1.6	-0.7
Had menopause	0.7	0.8	4.1	-0.1	2.0	-0.5	-0.6	-0.2	0.4
Had other major operations	0.3	0.4	1.0	-0.5	0.6	-0.4	-0.6	-0.6	1.0
Forced vital capacity (FVC)	0.2	0.7	2.1	-0.4	-1.4	-0.9	0.7	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.3	-1.3	1.8	1.3	-1.4	-1.7	0.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.4	-0.0	0.5	0.4	-2.1	-2.0	-0.2
Qualifications: None of the above	0.8	1.8	7.8	0.6	2.8	0.9	-0.2	-0.6	-1.2
Financial difficulties in last 2 years	0.3	0.4	2.0	1.4	0.6	0.1	0.1	0.2	0.3
Mouth/teeth dental problems	0.5	0.7	3.8	-0.3	-0.1	1.9	-0.1	-0.0	-0.8
Heart attack	1.8	2.3	5.5	0.1	-2.3	0.1	1.5	1.2	-2.1
Allergy	0.4	0.9	3.7	-0.6	0.4	0.8	-0.8	-0.4	1.9
Pain all over the body in last month	1.9	2.0	7.8	2.8	-0.5	0.5	-1.0	-1.5	0.8
Diabetes (self-reported)	2.1	3.2	12.5	-1.8	-3.5	1.4	0.9	0.9	0.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.5	-0.5	-2.1	0.3	1.7	1.9	0.2
Medication: Ramipril	0.6	0.8	1.1	-0.3	-0.7	1.0	-1.1	-1.1	-0.8
Medication: Simvastatin	1.5	2.2	10.3	-1.3	-3.2	-0.2	0.9	0.3	-0.7
Fluid intelligence score	0.8	1.7	2.8	1.7	-1.3	-0.8	1.2	1.0	-1.6
Illnesses of siblings	0.3	0.4	1.3	-0.2	-0.6	-0.1	0.5	0.8	1.1
Neuroticism score	0.6	1.3	4.4	-0.6	0.1	1.2	-1.0	-0.6	2.1
Weight	0.1	0.7	2.4	0.7	-0.6	-1.6	0.6	0.4	-0.4
Impedance of arm (right)	0.5	2.4	6.1	2.5	2.3	-0.7	0.8	0.3	-1.4
Arm fat percentage (right)	0.3	1.2	2.7	1.6	0.2	0.3	1.7	1.3	-0.7
Trunk fat-free mass	0.2	1.1	3.1	-1.0	-1.2	-1.8	-0.7	-0.6	0.3
Hip circumference	0.3	1.2	2.6	1.6	0.2	-1.6	0.9	0.6	-0.9
Time employed in main current job	1.3	1.5	4.6	0.6	0.4	-2.1	-1.3	-1.6	0.0
Alcohol intake versus 10 years previously	0.2	0.2	0.6	0.3	0.4	0.7	0.6	0.3	0.4
Father’s age at death	1.5	2.0	5.0	-2.1	0.1	0.9	1.0	0.8	2.2
Worrier / anxious feelings	0.5	1.0	4.9	-0.6	0.5	0.5	-0.5	-0.5	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.4	2.0	0.7	0.5	-0.5	0.1	2.1
Falls in the last year	0.7	1.0	4.5	0.5	0.5	2.1	-0.6	-0.6	-0.4
Hair/balding pattern: Pattern 3	0.5	0.8	2.2	-0.1	1.0	1.5	-0.8	-0.3	0.8
Number of live births	1.3	1.9	7.3	-1.3	0.9	2.7	-0.6	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.7	-1.0	-2.2	-0.3	1.4	1.1	1.4
Pulse rate	0.4	0.7	2.1	-0.8	-1.4	-0.1	-0.7	-0.7	0.7
Happiness	1.2	1.5	3.7	-1.1	-1.8	-0.3	-1.9	-0.6	-0.5
Noisy workplace	0.6	0.7	2.0	-1.4	0.7	-0.0	-1.2	-0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.0	-1.7	-1.4	-0.2	-1.0	-0.0	0.8
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.7	0.4	-2.2	2.3	1.4	2.4	0.3
Mouth/teeth dental problems: Dentures	0.7	1.1	3.8	1.4	0.7	-1.9	-0.5	-0.5	0.1
Asthma	1.1	2.2	10.8	0.3	0.1	-1.2	-0.7	-0.6	-3.3
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	9.3	-0.4	-0.3	-0.3	-0.4	0.1	3.0
Medication: Cholesterol lowering	1.1	1.7	4.4	-0.6	-2.1	1.8	1.0	0.9	-0.7
Depression (self-reported)	0.8	1.0	3.4	-1.0	-1.9	0.8	-0.4	-0.6	0.6
Medication: Lansoprazole	1.8	2.0	6.9	0.4	0.7	2.0	0.0	-0.7	-2.6
Prospective memory result	0.6	0.7	1.8	-1.4	1.0	0.1	0.7	0.3	0.9
Lung cancer (father)	1.0	1.2	3.5	-0.1	1.9	0.4	-1.1	-1.4	0.8
Illnesses of mother	0.3	0.4	0.7	0.6	-0.2	-0.8	-0.5	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.5	-1.3	-1.5	-0.8	1.9	1.8	1.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	-0.1	-1.0	0.2	-0.4	-0.7	-0.9
Impedance of arm (left)	0.7	3.0	7.0	2.6	2.2	-1.1	0.8	0.3	-2.1
Arm fat mass (right)	0.2	0.8	1.7	1.2	-0.4	-0.6	1.3	1.1	-0.1
Trunk predicted mass	0.2	1.0	2.9	-1.0	-1.2	-1.7	-0.7	-0.5	0.4
Standing height	0.4	3.9	20.5	0.7	0.2	-4.5	-0.7	-1.1	-0.8
Length of working week for main job	1.1	1.3	5.0	0.0	0.4	-0.8	1.3	2.2	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.1	0.5	0.0	-0.8	-0.5	-0.3
Breastfed as a baby	0.9	1.1	2.8	-0.2	-0.5	0.1	1.6	1.7	-0.9
Tense / ‘highly strung’	1.4	2.3	7.4	-2.7	-0.3	1.4	-0.8	-0.1	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.4	0.8	-1.6	1.1	0.5	1.1	0.6
Hair/balding pattern: Pattern 4	0.4	1.0	2.1	-1.4	-0.5	-1.0	0.8	1.1	-0.9
Birth weight of first child	1.2	2.2	5.5	0.9	-2.3	-2.1	1.2	0.9	0.1
Peak expiratory flow (PEF)	0.3	0.8	2.1	-1.4	-1.1	0.5	0.9	0.7	0.0
Pulse wave reflection index	1.1	1.3	4.1	-0.4	1.0	2.0	-0.9	-1.3	0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.5	0.2	-0.5	1.6	-0.5	-0.6	-0.3
Loud music exposure frequency	0.9	1.0	4.1	0.5	-2.0	0.7	0.4	0.7	-0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.2	-1.1	-2.1	-0.8	0.5	0.5	0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.0	0.1	-0.2	0.3	1.5	1.7	0.0
Blood clot in the leg (DVT)	0.8	1.0	5.8	0.1	-2.4	-0.4	0.4	-0.1	0.2
Medication: Paracetamol	0.4	0.7	1.9	0.5	1.0	-1.0	-0.1	0.5	1.4
Headache pain in last month	1.4	2.3	6.4	0.3	-1.4	0.1	1.3	1.9	2.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	5.5	1.0	2.4	-2.2	-0.6	-0.6	1.2
Glaucoma (self-reported)	0.7	0.9	2.5	-0.1	-1.2	0.1	1.0	0.5	1.6
Gout (self-reported)	1.3	1.7	4.1	-1.5	-0.2	2.0	1.4	1.2	0.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	7.6	0.4	-1.3	-2.2	0.3	0.7	-2.8
Medication: Amlodipine	3.0	4.2	9.4	0.3	-0.1	2.0	3.0	3.1	-1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.5	0.7	0.8	-1.2	0.2	0.3	-1.6
Birth weight	0.5	1.1	2.8	1.2	1.5	-1.7	-0.1	-0.2	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	0.3	1.2	-0.8	0.3	0.2	0.2
High blood pressure (siblings)	1.8	2.6	5.8	0.4	1.7	0.3	-1.8	-2.4	-1.8
Forced vital capacity (FVC), Best measure	0.3	1.2	2.0	-1.2	-1.2	-1.4	1.1	1.1	0.1
Body fat percentage	0.5	1.8	5.3	2.3	0.2	0.1	1.7	1.2	-1.0
Leg fat percentage (right)	0.3	1.2	4.1	2.0	-0.5	1.4	0.7	0.4	0.0
Arm fat-free mass (right)	0.2	1.1	2.9	-0.8	-1.4	-1.7	-0.7	-0.5	0.3
Exposure to tobacco smoke outside home	0.5	0.7	2.8	-1.7	-0.8	-0.0	-0.5	0.5	-0.2
Comparative body size at age 10	0.8	2.1	10.4	1.0	-3.2	0.6	0.2	0.9	0.0
Number of full brothers	0.7	0.9	2.3	0.8	0.6	1.5	0.6	-0.1	-1.3
Worry too long after embarrassment	1.0	1.6	3.8	-0.6	0.4	1.0	-1.9	-1.9	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	5.2	-0.1	-1.9	-0.1	-2.3	-1.8	1.4
Wheeze or whistling in the chest in last year	1.0	1.7	7.3	1.0	0.9	0.3	-1.0	-0.4	-2.7
Number of children fathered	1.6	1.8	8.7	0.2	-1.1	0.7	-0.0	-0.3	-3.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	-0.8	-1.0	-0.6	0.7	0.8	-0.5
Age at first live birth	0.6	1.0	2.9	-0.8	0.3	-0.8	1.7	1.3	0.1
Pulse wave peak to peak time	0.3	0.4	1.0	0.2	0.9	-0.5	0.2	0.6	1.0
Health satisfaction	0.6	0.8	2.9	-0.3	-0.5	0.9	-1.7	-0.8	0.1
Shortness of breath walking on level ground	0.5	0.6	1.4	-1.1	-0.1	0.8	-0.3	0.1	-1.2
Qualifications: College or University degree	0.5	1.7	4.2	-1.7	-2.1	-1.4	0.5	0.9	-0.0
Eye problems/disorders: None of the above	0.8	0.9	3.1	0.5	0.1	1.3	0.4	0.6	-1.8
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.9	1.1	0.0	-1.2	1.6	2.0	-1.5
Emphysema/chronic bronchitis	0.5	0.6	1.6	1.3	1.2	-0.2	-0.0	-0.5	0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	-1.3	0.5	-0.1	-0.2	-0.6	-1.0
Neck or shoulder pain in last month	0.6	0.9	3.1	-0.3	0.3	-0.3	-1.8	-1.3	0.4
Medication: Blood pressure	0.7	1.3	3.8	-0.3	-1.5	1.9	0.6	0.5	-1.0
Angina (self-reported)	1.0	1.3	4.1	-0.3	-2.0	1.0	0.4	-0.1	-1.5
Migraine (self-reported)	0.5	0.6	1.3	-0.3	-1.1	0.6	0.5	0.4	1.1
Medication: Ibuprofen	1.2	1.4	5.9	-0.9	-0.0	-0.8	0.6	0.8	2.4
Medication: Allopurinol	0.8	1.0	3.3	-1.8	0.9	1.3	0.2	0.4	-0.6
Medication: Omeprazole	0.4	0.5	1.9	0.2	-0.2	1.4	0.7	0.7	-0.4
Medication: Seretide 50 evohaler	1.5	1.7	3.6	1.6	-0.4	-1.9	1.5	1.1	0.2
Mean time to correctly identify matches	0.7	1.3	3.8	0.4	-0.5	1.6	0.5	0.9	-2.0
Heart disease (mother)	0.1	0.1	0.2	-0.1	-0.5	-0.2	-0.1	-0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.6	0.6	0.4	0.6	-1.4	-1.6	-0.6
Whole body fat mass	0.2	0.8	2.7	1.6	-0.3	-0.6	1.1	0.7	-0.5
Leg fat mass (right)	0.2	0.6	2.1	1.5	-0.6	0.2	0.8	0.6	0.1
Arm predicted mass (right)	0.2	0.9	3.0	-0.6	-1.2	-1.7	-0.4	-0.2	0.3
Pulse rate, automated reading	0.2	0.6	2.1	-0.9	0.2	0.5	0.5	0.3	1.5
Alcohol intake frequency.	0.2	0.4	1.2	-0.1	-0.4	1.1	-0.6	-0.9	-0.3
Comparative height size at age 10	0.3	1.7	3.3	-0.4	-0.6	-1.7	-1.2	-1.4	-1.8
Number of full sisters	1.3	1.6	6.0	-0.9	-0.7	2.4	0.7	1.2	-0.4
Suffer from ‘nerves’	2.4	3.7	7.8	-1.8	1.1	0.7	-2.3	-2.0	2.8
Overall health rating	0.6	1.2	3.2	1.0	-0.8	1.8	-0.8	-0.2	1.4
Chest pain or discomfort	0.3	0.5	1.5	0.0	0.9	1.2	-0.2	-0.4	-0.6
Had major operations	0.4	0.5	1.2	-0.3	-0.8	-0.7	-0.6	-1.1	0.2
Age at last live birth	0.8	1.1	2.5	-0.6	0.5	-1.6	1.3	0.8	1.2
Family relationship satisfaction	0.4	0.5	0.8	-0.5	-0.6	-0.9	-0.8	0.7	0.7
Leg pain on walking	1.1	1.4	5.3	-1.2	-0.7	0.4	0.6	0.8	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.8	-0.2	-1.0	-1.4	1.0	0.5	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	0.1	0.2	-0.0	0.9	0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.5	-0.4	0.9	-1.6	-0.0	0.1	-0.9
Medication: Aspirin	1.1	1.5	5.1	0.1	-2.2	1.1	1.0	1.1	-0.5
Supplements: Vitamin C	0.4	0.4	1.7	0.3	0.2	0.1	-0.6	-1.3	-0.7
Knee pain experienced in last month	1.3	2.1	3.4	-1.6	-1.7	-1.8	-0.8	-0.3	-1.7
Hypertension (Self-reported)	0.3	0.8	4.5	0.2	-0.2	2.1	-0.3	0.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	0.2	1.0	0.4	0.5	1.1	-1.2
Illnesses of father: Heart disease	0.8	1.1	2.7	-0.0	-0.4	1.1	1.5	1.6	-0.4
Illnesses of siblings: Diabetes	2.6	3.2	10.3	-0.9	-1.8	3.2	1.4	1.4	-1.0
Smoking status: Previous	0.1	0.1	0.3	0.1	-0.3	-0.5	0.4	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	0.3	-0.8	0.0	0.4	0.5	-0.2
Whole body fat-free mass	0.2	0.9	3.5	-0.8	-1.1	-1.9	-0.4	-0.3	0.2
Leg fat-free mass (right)	0.2	1.0	4.8	-0.6	-1.0	-2.2	0.1	0.2	0.1
Arm fat percentage (left)	0.3	1.4	3.0	1.6	0.1	0.0	1.7	1.3	-0.9
Average weekly red wine intake	0.9	1.3	3.4	0.2	-1.3	-1.6	-0.2	0.2	-1.8
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.6	-0.2	0.7	-0.0	-1.6	-1.5	-0.9
Mood swings	0.9	1.6	3.0	0.3	-1.7	0.9	1.2	1.5	1.4
Loneliness, isolation	1.1	1.5	2.5	-0.7	-0.6	1.5	1.1	1.6	1.5
Long-standing illness, disability or infirmity	1.5	2.3	11.0	0.1	-3.3	1.0	0.3	-0.4	-1.3
Ever had bowel cancer screening	0.1	0.1	0.4	0.1	0.6	0.1	-0.2	-0.2	-0.6
Diabetes diagnosed by doctor	2.0	3.3	14.7	-1.4	-3.8	1.0	1.1	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.7	-0.1	-1.6	0.2	-1.4	-0.9	-0.3
Friendships satisfaction	0.4	0.5	1.1	-0.8	-0.6	1.0	-0.7	-0.2	0.7
Qualifications: nursing, teaching	0.7	1.0	2.1	0.4	-1.1	1.2	0.8	1.4	0.8
Commuting to job workplace: Walk	0.4	0.5	1.0	-1.0	0.3	0.3	-1.0	0.1	-0.9
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.7	0.0	0.0	0.3	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.8	-1.3	-1.3	-1.2	-0.4	-0.5	1.2
Medication for cholesterol	0.6	0.8	1.3	-1.1	1.1	-0.9	-0.7	-0.7	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	1.3	-1.1	-1.1	-0.5	-0.3	0.1
Back pain experienced in last month	1.8	2.7	7.2	0.3	-0.5	2.7	-1.9	-2.0	1.0
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	0.4	-0.2	0.6	-0.2	-0.5
Breast cancer (self-reported)	2.1	2.5	7.5	-2.7	-0.8	0.1	2.5	0.9	0.5
Asthma (self-reported)	1.3	2.6	12.0	0.4	0.1	-1.4	-0.9	-0.8	-3.5
Osteoporosis (self-reported)	0.9	1.1	5.6	0.4	0.3	-2.4	-0.1	-0.6	-0.5
Osteoarthritis (self-reported)	0.6	0.8	3.3	0.9	0.2	-0.5	-0.5	0.1	1.8
Medication: Aspirin	1.0	1.3	4.6	-0.3	-2.1	0.8	0.9	0.9	-0.9
Medication: Gliclazide	0.5	0.6	2.1	-0.8	-0.2	0.3	0.5	0.6	1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-1.4	0.2	-1.3	-0.1	0.1	0.3
Smoking status: Current	0.6	0.9	4.6	0.5	2.1	0.8	-0.3	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	5.3	-0.7	-0.6	0.8	1.7	1.5	2.3
Whole body water mass	0.2	1.0	3.5	-0.8	-1.2	-1.9	-0.5	-0.3	0.2
Leg predicted mass (right)	0.2	1.1	4.8	-0.7	-1.0	-2.2	0.1	0.2	0.1
Arm fat mass (left)	0.2	0.7	1.5	1.2	-0.2	-0.7	1.1	0.9	-0.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	-0.7	-1.1	0.1	0.1	0.4	-1.2
Average weekly champagne plus white wine intake	0.6	0.9	1.4	-1.2	-1.2	-0.4	1.2	0.9	0.4
Miserableness	0.9	1.6	7.4	-0.1	-1.1	0.7	-0.5	0.1	2.7
Guilty feelings	0.8	1.2	2.6	1.4	1.5	0.2	-0.5	0.0	1.6
Wears glasses or contact lenses	0.3	0.3	0.8	0.1	-0.2	0.8	0.9	0.5	0.4
Ever taken oral contraceptive pill	1.2	1.4	5.7	-2.4	0.8	-0.5	0.3	0.8	-1.0
Hearing aid user	0.3	0.4	1.7	-0.3	-1.3	-0.4	0.6	-0.1	0.1
Mother’s age at death	0.5	0.6	1.1	0.3	-0.8	0.3	1.1	0.5	1.1
Financial situation satisfaction	0.8	1.0	2.3	0.4	-1.5	0.1	0.8	1.5	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.1	-0.6	-1.1	-0.8	1.8	1.2	-0.4
Commuting to job workplace: Public transport	0.6	0.7	1.7	-0.9	-0.2	-1.3	1.0	0.5	-0.4
Eye problems/disorders: Glaucoma	1.0	1.2	3.3	-0.6	-1.8	0.5	1.0	0.4	1.5
Medication: Blood pressure	0.2	0.4	1.1	1.1	0.2	0.6	-0.2	0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.6	1.6	-0.5	-0.9	0.2	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.2	-0.7	-0.1	1.8	-0.9	-0.4	-0.1
High cholesterol (Self-reported)	1.0	1.8	6.7	-1.5	-2.6	-0.5	-0.1	-0.4	-1.1
Medication: Bendroflumethiazide	0.4	0.6	1.9	1.4	0.3	0.0	0.2	-0.1	-1.2
Medication: Paracetamol	0.5	0.8	1.5	0.4	1.2	-1.2	0.2	0.6	0.9
Medication: Lisinopril	0.4	0.5	1.8	-0.6	-1.3	-0.2	0.0	0.2	0.8
Medication: Atorvastatin	0.7	0.8	2.7	-0.7	-1.0	1.6	-0.8	-0.5	0.0
Illnesses of father: High blood pressure	1.2	1.5	4.6	-0.1	-1.1	2.1	-0.9	-0.3	1.6
Alcohol drinker status: Never	0.2	0.3	0.9	0.1	-1.0	0.5	-0.1	0.1	-0.6
Ever smoked	0.3	0.5	1.2	-0.4	1.1	0.2	-1.1	-0.6	0.2
Basal metabolic rate	0.1	0.8	3.3	-0.5	-1.1	-1.8	-0.2	-0.2	0.1
Leg fat percentage (left)	0.2	0.9	3.0	1.7	-0.3	1.0	0.9	0.6	-0.0
Arm fat-free mass (left)	0.2	0.8	2.5	-0.5	-1.0	-1.6	-0.5	-0.2	0.8
Number of operations (self-reported)	0.5	0.8	1.4	-0.8	-0.5	-1.2	-0.8	-1.2	-0.7
Average weekly beer plus cider intake	0.6	0.8	1.3	0.4	0.7	-1.1	-0.9	-1.1	1.1
Irritability	0.2	0.4	1.3	-0.1	-0.4	0.6	-0.5	-0.1	1.1
Risk taking	0.8	1.1	3.2	0.4	1.8	-1.7	-0.3	0.5	0.5
Ever had prostate specific antigen (PSA) test	1.4	1.6	7.3	0.4	0.4	1.4	-0.1	-0.4	-2.7
Fractured/broken bones in last 5 years	1.9	2.5	8.3	1.2	-0.1	-2.1	-1.0	-0.3	-2.9
Age started oral contraceptive pill	0.3	0.4	1.4	1.2	0.3	-0.7	0.3	0.1	-0.2
Diastolic blood pressure, automated reading	0.4	1.2	4.3	-1.3	2.1	0.2	-0.8	-0.7	0.1
Ever depressed for a whole week	0.5	0.6	1.6	0.6	0.1	0.6	-1.3	-0.9	0.6
Unable to work because of sickness or disability	0.3	0.4	1.3	0.2	0.1	0.2	-1.0	-1.1	0.2
Commuting to job workplace: Cycle	0.5	0.6	1.8	0.2	-1.3	-0.5	0.3	-0.2	1.1
Myopia	0.7	1.0	3.0	-1.6	-0.1	-1.7	0.1	0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.9	-0.3	0.6	-2.0	0.0	-0.4	0.8
Cholesterol lowering medication	0.6	0.9	4.6	-0.4	-2.1	-0.8	0.1	-0.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.0	0.4	-0.6	1.7	0.9	0.9	-0.5
Pain experienced in last month	0.4	0.7	2.8	-1.0	0.7	-0.0	0.0	0.2	-1.7
Supplements: Calcium	0.7	0.8	1.8	0.9	0.9	-0.2	-0.6	-0.8	1.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.7	0.4	-0.6	-0.4	-1.0	-0.6
Heart attack/myocardial infarction (self-reported)	1.8	2.4	6.6	-0.1	-2.6	0.2	1.3	1.0	-2.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	6.0	0.0	-2.4	-0.3	0.5	-0.1	0.2
Heart disease (siblings)	1.4	1.7	3.7	1.9	-0.4	-0.7	1.3	1.4	-1.5
Alcohol drinker status: Previous	0.2	0.2	0.8	0.2	0.0	-0.1	-0.5	-0.9	0.2
Pack years of smoking	0.9	1.4	3.0	1.7	-1.3	0.5	0.8	1.4	0.8
Impedance of whole body	0.4	1.9	5.2	2.3	2.0	-0.3	0.5	-0.1	-1.3
Leg fat mass (left)	0.1	0.4	1.3	1.1	-0.5	-0.1	0.8	0.6	0.0
Arm predicted mass (left)	0.1	0.7	1.6	-0.6	-1.2	-1.2	-0.6	-0.4	0.7