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chr10:119,742,699-122,399,277

Best TWAS P=9.06e-30 · Best GWAS P=3.87e-55 conditioned to 1.82e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MCMBP	0.11	0.01	blup	518	0.05	4.6e-07	-11.158	-8.0	1.2e-15	-0.08	0.50	0.02	TRUE
2	GTEx	Adipose Subcutaneous	INPP5F	0.13	0.01	lasso	5	0.01	4.0e-02	-7.335	9.4	6.9e-21	0.27	0.12	0.25	FALSE
3	GTEx	Breast Mammary Tissue	PRDX3	0.27	0.00	enet	30	0.02	3.9e-02	15.640	10.2	3.2e-24	0.63	0.01	0.92	FALSE
4	GTEx	Breast Mammary Tissue (Female)	PRDX3	0.34	0.11	enet	31	0.12	1.9e-04	10.390	10.9	7.6e-28	0.64	0.02	0.78	TRUE
5	GTEx	Cells EBV-transformed lymphocytes	PRDX3	0.27	0.12	enet	8	0.16	5.1e-06	7.154	6.9	6.5e-12	0.13	0.44	0.04	FALSE
6	GTEx	Cells Transformed fibroblasts	BAG3	0.13	0.03	lasso	5	0.03	5.1e-03	6.117	5.8	5.9e-09	-0.04	0.64	0.02	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	FAM45A	0.24	0.13	enet	51	0.09	2.7e-04	10.827	11.3	9.1e-30	0.30	0.03	0.80	TRUE
8	GTEx	Esophagus Gastroesophageal Junction	BAG3	0.44	0.32	lasso	8	0.32	2.1e-12	4.059	7.0	2.7e-12	0.26	0.99	0.01	FALSE
9	GTEx	Esophagus Mucosa	CACUL1	0.26	0.10	lasso	4	0.10	5.4e-07	5.537	6.8	1.4e-11	-0.02	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	SEC23IP	0.11	0.02	lasso	3	0.02	3.4e-02	9.118	8.0	1.6e-15	0.00	0.31	0.03	TRUE
11	GTEx	Heart Atrial Appendage	CACUL1	0.35	0.19	lasso	6	0.18	1.2e-08	7.346	6.4	1.2e-10	-0.05	0.99	0.00	FALSE
12	GTEx	Heart Atrial Appendage	MCMBP	0.22	0.00	enet	22	0.00	1.9e-01	-9.368	9.7	4.1e-22	0.32	0.09	0.22	FALSE
13	GTEx	Muscle Skeletal	SEC23IP	0.16	0.08	enet	17	0.10	1.2e-09	-3.629	9.2	4.5e-20	0.09	1.00	0.00	TRUE
14	GTEx	Muscle Skeletal	PRDX3	0.10	0.10	lasso	3	0.10	4.2e-10	8.760	9.0	2.2e-19	0.15	1.00	0.00	TRUE
15	GTEx	Skin Not Sun Exposed Suprapubic	CACUL1	0.22	0.03	enet	35	0.07	7.4e-05	-8.422	6.1	1.0e-09	0.14	0.56	0.02	FALSE
16	METSIM	Adipose	PRDX3	0.07	0.05	lasso	7	0.05	1.3e-07	8.760	8.0	1.9e-15	0.19	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	CACUL1	0.12	0.08	lasso	4	0.06	1.2e-08	-8.646	8.4	2.9e-17	0.03	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	PRDX3	0.13	0.02	enet	33	0.06	4.4e-08	0.015	7.6	2.1e-14	0.06	0.69	0.01	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	INPP5F	0.14	0.07	lasso	5	0.12	2.7e-15	-8.846	7.2	5.0e-13	0.15	1.00	0.00	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	GRK5	0.12	0.03	lasso	8	0.06	1.0e-08	6.888	-7.0	1.8e-12	-0.28	0.98	0.01	FALSE
21	YFS	Blood	BAG3	0.04	0.03	lasso	6	0.03	4.8e-10	6.117	-6.4	1.8e-10	0.01	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	INPP5F	0.02	0.00	blup	73	0.01	3.6e-03	0.397	5.1	2.9e-07	-0.06	0.03	0.03	TRUE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRDX3	0.03	0.03	blup	45	0.03	3.5e-04	9.896	7.4	1.0e-13	0.10	0.01	0.97	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BAG3	0.04	0.02	lasso	5	0.01	3.9e-02	6.117	5.3	1.1e-07	-0.01	0.04	0.10	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRDX3	0.03	0.00	blup	45	0.01	5.1e-02	-5.002	7.6	3.7e-14	0.14	0.02	0.39	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C10orf46	0.23	0.04	lasso	4	0.04	8.6e-03	-8.646	8.8	1.3e-18	0.03	0.01	0.52	TRUE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	INPP5F	0.08	0.00	blup	73	0.03	2.8e-04	1.610	5.7	1.4e-08	-0.03	0.06	0.03	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	PRDX3	0.06	0.07	lasso	2	0.05	5.2e-06	8.760	8.6	6.5e-18	0.14	0.09	0.91	FALSE
29	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	INPP5F	0.35	0.05	enet	26	0.07	5.2e-03	1.951	7.4	1.3e-13	0.02	0.02	0.11	TRUE