Best TWAS P=2.46e-29 · Best GWAS P=3.05e-28 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-298P3.4 | 0.09 | 0.01 | lasso | 7 | 0.00 | 1.9e-01 | 8.58 | 9.0 | 1.5e-19 | 0.87 | 0.04 | 0.91 | FALSE |
| 2 | GTEx | Artery Aorta | PDS5B | 0.19 | 0.01 | enet | 30 | 0.02 | 2.2e-02 | 0.93 | 5.5 | 3.6e-08 | 0.31 | 0.08 | 0.25 | FALSE |
| 3 | GTEx | Artery Aorta | N4BP2L2 | 0.13 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | 11.02 | 11.2 | 2.5e-29 | 0.99 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Nerve Tibial | RP11-298P3.4 | 0.06 | 0.01 | enet | 19 | 0.01 | 7.8e-02 | 8.60 | 5.8 | 7.2e-09 | 0.67 | 0.09 | 0.66 | FALSE |
| 5 | GTEx | Whole Blood | KL | 0.12 | 0.00 | lasso | 7 | 0.00 | 4.9e-01 | -0.59 | -5.9 | 4.4e-09 | -0.58 | 0.13 | 0.12 | FALSE |
| 6 | YFS | Blood | PDS5B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.4e-11 | 8.04 | 8.0 | 8.9e-16 | 0.80 | 0.25 | 0.75 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CG030 | 0.06 | 0.01 | blup | 38 | 0.03 | 6.0e-04 | -7.14 | -10.2 | 3.0e-24 | -0.83 | 0.01 | 0.80 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CG030 | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.1e-04 | 11.02 | -11.1 | 1.4e-28 | -0.98 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | 10.62 | 10.7 | 1.0e-26 | 0.98 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CG030 | 0.07 | 0.02 | lasso | 4 | 0.03 | 2.4e-04 | 10.96 | -9.5 | 2.7e-21 | -0.85 | 0.00 | 0.79 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | N4BP2L2 | 0.04 | 0.03 | blup | 69 | 0.02 | 9.4e-04 | 11.02 | 11.0 | 4.6e-28 | 0.97 | 0.00 | 0.98 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CG030 | 0.06 | 0.01 | blup | 38 | 0.02 | 1.9e-03 | -7.93 | -9.7 | 2.7e-22 | -0.83 | 0.02 | 0.86 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | N4BP2L2 | 0.10 | 0.10 | lasso | 4 | 0.11 | 5.2e-12 | 11.02 | 10.5 | 1.2e-25 | 0.97 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | N4BP2L2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 2.8e-03 | 10.50 | 10.1 | 5.3e-24 | 0.88 | 0.01 | 0.95 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | 10.62 | 10.4 | 2.2e-25 | 0.98 | 0.01 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CG030 | 0.08 | 0.04 | blup | 38 | 0.04 | 1.4e-03 | 10.96 | -10.3 | 5.3e-25 | -0.93 | 0.00 | 0.92 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CG030 | 0.12 | 0.02 | blup | 38 | 0.03 | 3.1e-02 | 10.79 | -8.3 | 9.2e-17 | -0.84 | 0.00 | 0.59 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KL | 0.09 | 0.04 | lasso | 6 | 0.04 | 7.2e-05 | -5.57 | -5.3 | 9.7e-08 | 0.07 | 0.02 | 0.82 | TRUE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | N4BP2L2 | 0.06 | 0.03 | lasso | 3 | 0.05 | 1.0e-05 | -5.22 | 8.3 | 1.4e-16 | 0.81 | 0.02 | 0.98 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | N4BP2L2 | 0.12 | 0.14 | enet | 7 | 0.16 | 1.1e-15 | 9.42 | 10.4 | 2.2e-25 | 0.98 | 0.01 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | 10.33 | -10.0 | 1.1e-23 | -0.92 | 0.02 | 0.86 | FALSE |