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chr14:58,180,290-62,137,964

Best TWAS P=3.21e-84 · Best GWAS P=6.42e-127 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PPM1A	0.10	0.10	lasso	2	0.10	1.1e-08	5.7	5.7	1.6e-08	-0.01	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RTN1	0.14	0.12	lasso	3	0.10	6.1e-09	5.4	-5.8	5.5e-09	-0.01	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	C14orf39	0.08	0.05	lasso	8	0.06	2.1e-05	14.0	-14.1	5.9e-45	-0.41	0.92	0.02	FALSE
4	GTEx	Adipose Subcutaneous	GPR135	0.08	0.09	lasso	6	0.07	3.2e-06	5.0	-5.2	2.6e-07	-0.14	0.99	0.00	FALSE
5	GTEx	Artery Aorta	JKAMP	0.11	0.03	lasso	2	0.02	2.9e-02	-5.6	-5.4	7.4e-08	-0.07	0.11	0.04	FALSE
6	GTEx	Artery Aorta	RTN1	0.35	0.30	enet	20	0.34	1.9e-19	-5.4	-5.2	1.7e-07	-0.08	1.00	0.00	FALSE
7	GTEx	Artery Coronary	RTN1	0.21	0.12	lasso	7	0.10	2.5e-04	-5.4	-5.8	5.0e-09	-0.11	0.40	0.04	FALSE
8	GTEx	Artery Tibial	RTN1	0.42	0.32	enet	34	0.45	3.2e-38	-5.4	-5.8	6.3e-09	-0.08	1.00	0.00	FALSE
9	GTEx	Artery Tibial	CCDC175	0.25	0.17	enet	11	0.25	9.0e-20	-5.4	-6.1	1.1e-09	-0.09	1.00	0.00	FALSE
10	GTEx	Artery Tibial	RP11-701B16.2	0.20	0.15	lasso	4	0.16	2.2e-12	-5.4	-6.1	8.3e-10	-0.09	1.00	0.00	FALSE
11	GTEx	Breast Mammary Tissue	GPR135	0.12	0.01	lasso	4	0.04	6.5e-03	-6.0	-7.0	2.0e-12	-0.12	0.13	0.04	FALSE
12	GTEx	Breast Mammary Tissue (Female)	GPR135	0.07	0.03	lasso	3	0.00	2.7e-01	-5.4	-6.4	1.5e-10	-0.12	0.05	0.05	TRUE
13	GTEx	Cells EBV-transformed lymphocytes	GPR135	0.33	0.04	enet	23	0.15	1.7e-05	6.3	-8.9	4.4e-19	-0.11	0.14	0.06	TRUE
14	GTEx	Cells Transformed fibroblasts	RP11-193F5.4	0.06	0.00	enet	16	0.01	6.5e-02	13.6	11.0	2.5e-28	0.33	0.11	0.11	FALSE
15	GTEx	Colon Transverse	JKAMP	0.14	0.10	lasso	3	0.12	2.4e-06	-5.7	-6.2	5.3e-10	-0.06	0.77	0.01	FALSE
16	GTEx	Colon Transverse	GPR135	0.15	0.17	enet	11	0.12	3.1e-06	5.3	-6.2	5.2e-10	-0.12	0.96	0.00	FALSE
17	GTEx	Esophagus Mucosa	GPR135	0.10	0.00	enet	10	0.02	1.6e-02	-5.7	-6.2	4.9e-10	-0.09	0.38	0.04	FALSE
18	GTEx	Esophagus Muscularis	C14orf39	0.10	0.02	enet	9	0.02	2.9e-02	4.9	-5.4	5.3e-08	-0.41	0.11	0.18	TRUE
19	GTEx	Heart Atrial Appendage	GPR135	0.14	0.08	lasso	9	0.07	3.1e-04	4.2	-6.1	8.9e-10	-0.14	0.76	0.02	FALSE
20	GTEx	Liver	MNAT1	0.21	0.00	lasso	4	-0.01	5.4e-01	5.9	-15.9	3.9e-57	-0.44	0.08	0.20	FALSE
21	GTEx	Muscle Skeletal	C14orf39	0.06	0.05	lasso	3	0.05	2.7e-05	14.0	-19.4	3.2e-84	-0.67	0.12	0.86	TRUE
22	GTEx	Nerve Tibial	PPM1A	0.18	0.12	lasso	2	0.10	7.4e-08	5.7	5.7	1.2e-08	-0.01	0.97	0.00	FALSE
23	GTEx	Ovary	GPR135	0.23	0.18	lasso	4	0.19	1.7e-05	5.2	-5.3	1.5e-07	-0.13	0.52	0.03	FALSE
24	GTEx	Pituitary	C14orf39	0.39	0.38	enet	20	0.35	1.0e-09	14.0	-11.8	2.6e-32	-0.34	0.98	0.00	TRUE
25	GTEx	Pituitary	RP11-701B16.2	0.35	0.03	enet	24	0.13	4.3e-04	5.7	-6.6	3.1e-11	-0.10	0.11	0.11	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	PPM1A	0.21	0.21	lasso	3	0.18	2.2e-10	5.7	6.0	2.4e-09	0.01	1.00	0.00	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	PCNXL4	0.15	0.05	enet	15	0.12	6.2e-07	3.5	-15.1	3.0e-51	-0.61	0.76	0.09	FALSE
28	GTEx	Skin Sun Exposed Lower leg	PPM1A	0.21	0.18	lasso	3	0.15	1.2e-12	5.9	6.4	1.4e-10	0.04	1.00	0.00	TRUE
29	GTEx	Stomach	JKAMP	0.15	0.00	lasso	6	0.00	1.8e-01	-5.7	-5.5	3.2e-08	-0.09	0.10	0.10	TRUE
30	GTEx	Thyroid	TIMM9	0.14	0.02	lasso	4	0.03	2.6e-03	-3.8	-5.5	3.2e-08	-0.08	0.13	0.62	TRUE
31	GTEx	Thyroid	RTN1	0.12	0.12	lasso	4	0.12	3.4e-09	5.4	-5.7	1.5e-08	-0.12	1.00	0.00	FALSE
32	GTEx	Thyroid	CCDC175	0.07	0.00	lasso	7	0.00	1.9e-01	5.4	-7.0	1.9e-12	-0.07	0.13	0.03	FALSE
33	METSIM	Adipose	RTN1	0.08	0.07	enet	10	0.07	2.0e-10	5.4	-5.4	5.9e-08	-0.06	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JKAMP	0.20	0.14	enet	3	0.14	3.0e-08	-5.6	-5.6	2.2e-08	-0.08	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	JKAMP	0.13	0.06	lasso	2	0.07	5.3e-08	-5.6	-5.2	1.5e-07	-0.06	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf39	0.02	0.02	blup	37	0.02	4.2e-03	13.8	-17.4	1.0e-67	-0.55	0.06	0.46	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	JKAMP	0.07	0.04	lasso	3	0.05	4.8e-06	-5.6	-6.5	5.8e-11	-0.10	0.00	0.99	TRUE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DHRS7	0.02	0.01	blup	43	0.02	4.9e-03	4.5	-6.0	2.3e-09	-0.14	0.02	0.34	TRUE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf39	0.08	0.05	blup	37	0.05	4.2e-03	13.2	-16.5	2.2e-61	-0.51	0.10	0.33	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf39	0.08	0.09	blup	37	0.11	1.8e-11	13.5	-16.4	1.3e-60	-0.51	0.99	0.01	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	DAAM1	0.14	0.04	blup	146	0.10	3.6e-10	-7.0	-5.5	3.8e-08	-0.09	0.01	0.99	FALSE