Hub : Genes

OSGIN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.2160	0.0760	0.00480	0.017	NA	0.027	NA	0.023	3.9e-02	NA	1.3e-02	NA	1.9e-02
2	YFS	Blood	0.0450	0.0154	0.00031	0.001	0.013	0.012	0.014	0.004	1.9e-01	2.9e-05	6.8e-05	1.3e-05	1.4e-02
3	TCGA	Brain Lower Grade Glioma	0.0374	0.0183	0.00940	0.014	0.020	0.014	NA	0.010	8.3e-03	2.2e-03	7.9e-03	NA	2.1e-02
4	TCGA	Pancreatic Adenocarcinoma	0.1830	0.0690	0.00260	-0.001	0.059	0.004	NA	0.013	3.6e-01	1.7e-03	2.1e-01	NA	9.0e-02
5	TCGA	Prostate Adenocarcinoma	0.2843	0.0474	0.00000	0.327	0.327	0.345	NA	0.333	5.7e-35	4.4e-35	3.0e-37	NA	8.0e-36

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.0	2.3	-0.2	1.5	-1.3	-0.7	-0.8
Bipolar Disorder or Schizophrenia	1.2	3.0	4.6	-0.9	1.8	-2.1	-1.6	-2.0
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	1.5	0.4	0.5	-0.4	0.4
Depression (Nagel 2018)	0.7	1.1	2.7	1.0	-1.0	1.7	0.2	0.8
Intelligence (Savage-Jansen 2018)	1.2	3.6	11.5	3.4	-0.6	1.9	-1.1	1.3
Neuroticism (Nagel 2018)	0.6	1.3	2.4	1.2	-0.9	1.3	-0.6	1.6
Schizophrenia (2018)	1.0	2.2	3.7	-0.9	1.0	-1.7	-1.6	-1.9
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.5	-0.3	0.3	-0.0	0.2
Worry (Nagel 2018)	0.4	0.8	1.7	-0.1	-1.3	0.1	-0.7	1.3
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	0.0	0.6	-0.9	-0.7	-0.2
Alzheimer’s Disease (in father)	1.0	1.1	4.8	2.2	-0.0	0.1	-0.7	-0.4
Alzheimer’s Disease (including proxy)	0.7	1.0	1.5	0.7	1.2	-1.0	-1.0	-1.0
Crohns Disease (2017)	0.5	1.0	2.9	-1.2	-0.3	-1.7	0.0	-0.9
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	-0.3	-0.6	-1.0	-0.5	0.0
Ulcerative Colitis (UC)	0.2	0.5	1.3	0.8	-0.3	0.4	0.2	1.1
Major Depression (MDD)	0.0	0.0	0.0	-0.1	0.2	0.0	0.0	0.0
Reaction Time	1.1	2.1	5.0	-1.7	2.2	-0.6	-0.9	-1.2
Verbal and Numeric Reasoning (VNR)	1.1	2.7	8.1	2.9	-0.2	1.5	-1.4	1.0
Breast Cancer	0.1	0.3	1.1	0.1	-1.0	0.2	0.4	0.2
Ovarian Cancer	0.5	0.7	1.2	-0.5	-0.2	-1.0	-1.1	-0.9
Prostate Cancer	0.5	0.7	1.6	-0.9	0.4	-1.3	0.5	-0.9
Age at First Birth	1.1	1.6	5.5	2.3	-0.9	-0.1	-0.1	1.4
Bipolar Disorder (2011)	0.5	0.5	2.4	0.0	1.5	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	3.1	4.2	6.3	-2.4	2.5	-1.5	-1.2	-2.3
Coronary Artery Disease (CAD)	2.2	2.6	6.9	1.9	-1.1	1.1	2.6	0.0
Crohns Disease (2012)	1.2	2.0	6.1	-0.4	-0.2	-1.7	2.5	-0.9
Mean Putamen Volume	2.1	2.4	4.4	1.6	-1.4	1.7	-0.4	2.1
Fasting Glucose	0.7	0.9	2.7	0.4	1.6	-0.6	-0.8	-0.7
HbA1C	0.7	0.8	2.1	0.8	-1.5	-0.9	-0.2	-0.6
HDL Cholesterol	0.6	1.0	2.8	-0.5	-1.4	0.1	1.7	0.4
LDL Cholesterol	0.7	1.0	3.3	-1.0	-0.6	0.5	1.8	0.5
Lupus	0.4	0.6	1.9	1.4	0.6	-0.6	-0.4	-0.8
Neuroticism (2016)	1.5	2.1	3.4	1.8	-1.5	1.7	0.3	1.4
Primary Biliary Cirrhosis	0.2	0.3	1.0	-0.4	1.0	-0.3	-0.0	-0.4
Rheumatoid Arthritis	0.5	0.6	1.8	0.1	1.1	0.5	0.1	1.3
Schizophrenia (2014)	1.1	2.5	6.0	-1.5	1.3	-1.3	-2.4	-0.9
Triglycerides	0.4	0.7	2.7	-1.6	0.7	-0.1	0.2	0.2
Type 2 Diabetes (T2D) (2012)	2.0	2.3	2.9	1.6	1.5	-1.7	-1.2	-1.6
Ulcerative Colitis	1.0	1.5	3.1	1.2	-1.1	1.0	0.8	1.8
Blood Eosinophil Count	0.1	0.5	0.7	-0.7	0.8	-0.4	-0.8	-0.8
Blood Platelet Count	0.5	5.9	13.7	0.6	-1.5	2.4	2.7	3.7
Blood Red Count	1.0	10.1	21.6	-1.3	2.3	-4.1	-2.3	-4.7
Blood White Count	0.2	1.2	4.5	-2.1	0.8	-0.5	-0.0	-0.8
Heel T-Score	0.0	0.3	0.8	-0.3	0.2	-0.9	0.2	-0.9
BMI	0.3	1.5	2.8	-1.2	1.7	-0.8	0.7	-1.5
Height	0.9	16.8	39.8	3.7	-0.7	5.2	1.8	6.3
Waist Hip Ratio (WHR)	0.4	1.8	2.9	-1.0	-0.6	1.4	1.6	1.7
Systolic Blood Pressure	0.1	0.6	1.5	0.1	0.0	-1.2	0.6	-0.9
Smoking Status	0.3	0.6	1.2	-0.9	0.2	0.9	0.2	1.1
Allergy or Eczema	0.9	2.3	4.5	0.5	-1.2	2.1	-1.7	1.5
Cardiovascular Disease	0.7	2.1	7.1	-0.5	0.2	-1.5	2.7	-1.1
Hypothyroidism (self reported)	0.7	1.7	2.8	-1.6	-1.1	-1.7	1.3	-0.4
Respiratory disease	0.2	0.5	1.0	-0.9	0.3	-0.7	-1.0	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.9	-0.0	-0.1	0.6	0.3	-0.9
Lung FEV1/FVC ratio	0.2	1.0	2.0	-0.2	-1.2	1.4	0.4	1.2
Lung FVC	0.0	0.2	0.5	0.4	0.7	-0.5	0.2	-0.5
Neuroticism	0.4	0.9	1.3	0.6	-0.6	1.1	-1.0	1.1
Chronotype (morning person)	0.3	0.7	2.7	-0.6	0.2	-1.6	0.3	-0.5
Hair Pigment	0.1	2.4	4.1	-1.1	2.0	-1.8	-0.9	-1.6
Tanning	0.1	1.1	2.2	1.0	0.4	-0.1	-1.5	-1.5
Hand grip strength (left)	1.1	3.0	6.0	1.8	-1.3	2.4	0.1	2.0
Number of treatments/medications taken	1.6	2.8	6.4	-1.6	0.1	-2.5	1.1	-2.0
Average weekly spirits intake	0.8	1.0	1.9	0.2	1.3	-1.4	1.0	-0.5
Sensitivity / hurt feelings	1.9	3.3	6.6	1.0	-1.2	2.6	-2.2	1.5
Frequency of depressed mood in last 2 weeks	1.4	1.9	4.3	1.8	-1.0	2.1	-0.3	1.1
Hearing difficulty/problems: Yes	0.3	0.5	1.7	-1.3	-0.4	0.6	-0.0	0.4
Relative age of first facial hair	0.3	0.6	2.2	-0.4	-0.4	0.5	1.5	0.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.2	-1.3	0.5	-1.5	1.1	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	0.1	-0.8	0.8	-0.5	0.9
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	-0.9	0.5	0.9	0.3	-0.9
Systolic blood pressure, automated reading	0.1	0.4	1.3	0.2	-0.4	-0.5	1.2	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.3	-0.9	-1.5	0.4	0.7	0.0
Angina	1.7	2.3	5.0	-0.2	-1.1	1.3	2.2	1.9
Medication for hormone replacement therapy	0.4	0.5	1.5	0.2	-0.5	1.2	0.2	0.8
Vitamin and mineral supplements	1.4	2.0	3.0	-1.7	-0.1	-1.5	1.5	-1.5
Supplements: Zinc	1.2	1.3	3.1	-0.1	0.1	1.8	-1.0	1.6
Medication: Co-codamol	0.9	1.1	2.6	-1.4	0.1	-0.9	1.6	-0.4
Medication: Metformin	1.1	1.6	4.7	-1.1	0.3	-1.4	0.0	-2.2
Diabetes (father)	0.3	0.3	1.0	-1.0	0.1	-0.6	0.3	-0.3
Diabetes (mother)	1.1	1.4	2.7	-1.2	0.5	-1.7	-0.4	-1.6
Severe depression (siblings)	0.9	1.0	3.5	-1.9	-0.3	-0.8	0.7	-0.7
Pack years adult smoking proportion	1.0	1.5	3.0	-0.9	0.1	-1.7	-1.0	-1.7
Impedance of leg (right)	0.5	2.5	7.2	2.7	-0.3	1.1	-1.0	1.7
Leg fat-free mass (left)	0.1	0.6	1.3	-0.4	0.3	1.1	0.9	0.6
Trunk fat percentage	0.8	3.1	4.0	-2.0	2.0	-1.7	1.2	-1.8
Hand grip strength (right)	2.6	7.1	12.1	3.1	-0.0	3.4	1.4	3.5
Townsend deprivation index at recruitment	0.5	0.7	2.7	0.1	-1.6	-0.4	-0.7	-0.1
Current tobacco smoking	0.6	1.0	2.4	-1.5	0.9	0.8	-0.6	0.9
Average weekly fortified wine intake	0.8	0.9	1.9	0.7	1.4	-1.1	-1.0	-0.1
Maternal smoking around birth	2.2	3.1	9.0	-3.0	-0.4	-0.4	2.5	-0.1
Fed-up feelings	0.5	0.9	1.9	1.4	-0.4	1.1	0.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.8	1.4	-1.4	2.2	0.3	1.9
Relative age voice broke	0.3	0.5	1.1	0.2	0.3	0.7	-1.0	-0.9
Taking other prescription medications	1.1	1.7	4.7	-2.2	-0.7	-1.4	-0.3	-1.2
Age when periods started (menarche)	1.6	3.9	8.8	3.0	-1.2	1.6	1.9	1.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.6	-0.4	0.4	0.6	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	-1.0	0.5	-0.2	0.3	0.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.8	1.3	0.7	-0.2	-1.9	-0.8
Qualifications: CSEs or equivalent	0.4	0.5	0.8	-0.9	-0.8	0.4	-0.9	-0.4
Serious illness, injury or assault to yourself	0.3	0.3	0.6	0.4	0.8	-0.4	0.0	-0.8
High blood pressure	1.3	3.7	5.0	-2.2	0.9	-2.2	2.2	-1.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.7	0.6	-1.0	1.9	-1.4	1.3
Multivitamins +/- minerals	1.4	1.8	3.1	1.6	-0.5	1.7	-0.3	1.8
Stomach or abdominal pain in last month	1.0	1.2	3.2	-0.8	-0.4	0.7	1.8	1.3
Supplements: Glucosamine	2.7	3.5	11.4	1.4	-1.6	1.1	-3.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.2	-0.2	0.6	0.9	0.8
Medication: Atenolol	0.3	0.4	0.8	0.0	-0.7	0.0	0.9	0.7
Medication: Levothyroxine sodium	1.1	1.9	4.0	-2.0	-0.1	-2.0	0.8	-1.1
Sitting height	0.9	6.7	13.2	2.6	-0.4	3.4	1.4	3.6
Chronic bronchitis/emphysema (father)	2.0	2.3	4.6	-2.0	-0.7	-1.5	-0.5	-2.2
High blood pressure (mother)	0.4	0.5	1.1	0.6	0.6	0.5	-1.0	-0.8
Body mass index (BMI)	0.7	3.1	6.0	-2.4	1.8	-1.5	0.6	-1.9
Impedance of leg (left)	0.4	1.7	4.9	2.2	-0.0	0.9	0.2	1.6
Leg predicted mass (left)	0.1	0.5	1.3	-0.4	0.3	1.1	0.9	0.6
Trunk fat mass	0.4	1.9	3.3	-1.6	1.8	-0.9	1.3	-1.0
Waist circumference	0.5	1.7	3.8	-2.0	1.0	-1.0	1.3	-1.1
Number of incorrect matches in round	0.5	0.8	2.0	-0.7	-1.4	-1.1	-0.1	-0.4
Past tobacco smoking	0.8	1.4	2.7	1.6	1.3	0.2	-1.6	0.4
Alcohol usually taken with meals	0.6	0.9	4.0	2.0	0.3	0.5	0.3	-0.4
Nervous feelings	0.2	0.3	0.9	-0.4	-0.9	-0.1	-0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.0	-0.8	1.0	0.1	0.8
Hearing difficulty/problems with background noise	0.4	0.6	2.7	-1.6	-0.2	-0.3	-0.4	-0.2
Hair/balding pattern: Pattern 2	2.1	2.6	5.1	0.6	-1.3	2.0	-1.4	2.3
Had menopause	0.8	1.0	2.5	1.0	-1.6	-0.4	-1.2	0.1
Had other major operations	0.6	0.8	1.0	-1.0	1.0	-0.8	1.0	-0.5
Forced vital capacity (FVC)	1.5	5.8	11.0	2.5	-1.0	3.3	0.8	3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.8	-1.3	1.1	-0.5	1.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	0.6	0.1	1.2	0.4	1.1
Qualifications: None of the above	0.9	1.8	3.5	-1.8	-0.9	-1.2	1.9	0.2
Financial difficulties in last 2 years	0.7	1.0	1.6	1.0	-1.0	1.1	0.1	1.3
Mouth/teeth dental problems	0.5	0.8	2.2	1.4	0.2	0.2	-1.5	-0.0
Heart attack	1.5	1.9	5.3	0.0	-0.7	1.2	2.3	1.5
Allergy	0.4	0.9	1.7	-0.2	0.8	-1.1	1.3	-0.8
Pain all over the body in last month	0.5	0.5	0.9	0.1	0.9	0.6	0.9	0.6
Diabetes (self-reported)	0.5	0.8	3.0	-0.4	0.5	-0.7	-0.5	-1.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	4.1	-0.6	-2.0	-0.4	-1.5	-0.6
Medication: Ramipril	2.8	3.5	9.2	-3.0	1.2	-1.0	2.2	-1.1
Medication: Simvastatin	2.3	3.4	5.0	-2.2	0.7	-2.0	2.1	-1.9
Fluid intelligence score	2.0	4.2	8.5	2.9	0.0	2.5	-0.3	2.4
Illnesses of siblings	0.4	0.5	2.2	-0.6	-0.2	-0.2	-1.5	0.1
Neuroticism score	0.5	1.0	1.7	0.6	-0.3	1.2	-1.3	1.1
Weight	0.2	0.8	1.4	-1.2	1.1	0.3	1.1	0.2
Impedance of arm (right)	0.3	1.2	2.3	0.3	-0.4	-1.2	-1.5	-1.5
Arm fat percentage (right)	1.1	4.2	6.2	-2.5	2.0	-2.1	0.3	-2.5
Trunk fat-free mass	1.0	5.7	12.7	1.3	-0.7	3.5	0.9	3.6
Hip circumference	0.2	0.8	1.2	-1.1	1.1	-0.6	0.5	-1.0
Time employed in main current job	1.5	1.7	3.3	-1.8	1.3	-0.5	-1.8	0.3
Alcohol intake versus 10 years previously	1.1	1.7	4.8	0.7	-0.9	1.1	1.2	2.2
Father’s age at death	0.6	0.8	2.9	0.5	-1.7	-0.3	-0.7	0.3
Worrier / anxious feelings	0.4	0.8	2.4	0.6	-0.5	0.8	-0.7	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.5	-1.2	-0.7	1.2	0.9	0.7
Falls in the last year	0.7	1.0	1.7	-0.4	1.2	-1.3	-0.3	-1.2
Hair/balding pattern: Pattern 3	1.1	1.6	5.1	-2.3	0.2	-1.6	0.1	-0.6
Number of live births	1.1	1.6	5.0	-1.1	1.0	-0.7	2.2	-0.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	10.0	2.6	-0.7	3.2	0.7	2.5
Pulse rate	0.3	0.5	1.0	0.1	1.0	-0.8	-0.9	-0.5
Happiness	1.2	1.5	3.6	1.4	-0.0	1.9	0.6	1.1
Noisy workplace	1.8	2.2	3.6	-1.9	1.4	-1.6	-0.1	-1.8
Qualifications: A levels/AS levels or equivalent	0.6	1.2	1.8	1.3	-1.1	0.6	-1.4	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.0	0.3	0.3	0.2	1.0	-0.6
Mouth/teeth dental problems: Dentures	0.6	1.0	2.9	-1.7	0.1	-0.5	1.3	0.1
Asthma	0.1	0.2	0.3	0.6	0.5	-0.2	-0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.5	0.3	0.7	0.6	0.5	0.7
Medication: Cholesterol lowering	1.3	2.0	8.8	-0.4	0.7	0.0	3.0	0.8
Depression (self-reported)	0.9	1.1	2.6	0.1	1.6	-0.3	-1.1	-1.2
Medication: Lansoprazole	0.7	0.8	2.0	-1.3	-0.1	0.3	-1.4	0.3
Prospective memory result	0.6	0.7	2.1	-0.5	1.5	-0.7	-0.6	-0.6
Lung cancer (father)	0.7	0.9	1.4	-0.5	1.1	1.1	-0.6	1.2
Illnesses of mother	0.1	0.1	0.3	-0.2	-0.4	-0.0	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	7.2	1.8	0.1	2.7	0.1	2.1
Pulse wave Arterial Stiffness index	1.7	2.0	4.2	-1.4	0.6	-2.1	-0.9	-1.7
Impedance of arm (left)	0.1	0.7	1.1	0.5	-0.3	-1.0	-0.9	-1.1
Arm fat mass (right)	0.5	2.1	3.3	-1.8	1.8	-1.2	0.7	-1.4
Trunk predicted mass	1.0	5.5	12.6	1.2	-0.7	3.4	0.9	3.5
Standing height	1.0	10.3	22.9	2.9	-1.4	4.2	0.9	4.8
Length of working week for main job	0.5	0.6	1.6	-0.7	0.4	-0.6	0.6	-1.3
Exposure to tobacco smoke at home	2.9	3.3	5.5	-0.7	-2.2	0.9	2.2	2.4
Breastfed as a baby	0.8	1.0	2.4	-0.4	1.1	-1.5	-0.0	-1.2
Tense / ‘highly strung’	1.2	2.0	6.6	-2.6	-1.2	-0.4	1.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.5	0.9	0.1	-0.7	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.8	0.6	0.3	-0.4	-0.3
Birth weight of first child	0.7	1.2	3.0	-1.7	0.8	-0.3	1.5	-0.0
Peak expiratory flow (PEF)	1.4	3.4	7.1	2.7	-0.2	2.7	-0.4	1.6
Pulse wave reflection index	1.1	1.4	2.3	-0.9	-0.5	-1.2	-1.5	-1.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.9	0.2	0.5	-0.3	-0.1
Loud music exposure frequency	2.1	2.3	7.7	-0.4	2.8	-1.1	0.8	-1.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.2	0.7	-1.4	0.6	-1.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-0.6	1.3	-0.7	0.8	-0.7
Blood clot in the leg (DVT)	0.4	0.5	1.9	0.2	0.7	-0.5	-0.2	-1.4
Medication: Paracetamol	0.6	1.0	2.7	-1.6	1.3	-0.4	0.2	0.4
Headache pain in last month	1.5	2.5	7.3	1.7	-0.1	1.6	0.0	2.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	7.3	-0.3	-0.6	-0.3	-2.7	-0.8
Glaucoma (self-reported)	0.4	0.5	1.3	-0.7	-1.1	0.5	0.7	-0.2
Gout (self-reported)	2.2	3.0	6.5	-1.9	2.5	-1.6	-0.4	-1.6
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.5	-2.3	-0.7	-1.7	1.2	-0.2
Medication: Amlodipine	0.8	1.2	3.3	-0.6	0.6	-1.8	-0.4	-1.2
Medication: Ventolin 100micrograms inhaler	1.7	2.2	8.5	0.8	1.3	-0.1	-2.9	-0.3
Birth weight	1.9	4.2	10.9	0.3	-1.3	3.3	-0.6	2.8
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.9	-0.0	-1.2	1.7	0.2	1.3
High blood pressure (siblings)	0.8	1.2	2.8	-0.1	0.3	-1.0	1.4	-1.7
Forced vital capacity (FVC), Best measure	0.9	3.2	7.0	1.8	0.1	2.6	0.1	2.4
Body fat percentage	0.9	3.4	4.7	-2.2	2.1	-1.8	1.1	-1.9
Leg fat percentage (right)	0.6	2.2	3.6	-1.6	1.9	-1.4	0.7	-1.6
Arm fat-free mass (right)	0.8	4.0	9.0	0.7	-0.2	2.6	1.9	3.0
Exposure to tobacco smoke outside home	0.8	1.1	2.3	-0.4	-0.5	-1.5	1.5	-0.7
Comparative body size at age 10	0.3	0.7	1.9	-0.4	-0.2	-1.1	0.4	-1.4
Number of full brothers	0.8	1.1	2.7	-0.5	1.6	1.3	-0.7	0.2
Worry too long after embarrassment	1.0	1.7	2.2	1.2	-1.5	1.4	-0.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.6	0.4	-0.3	-0.6	-0.7
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	0.6	0.2	0.8	-1.0	1.1
Number of children fathered	1.2	1.3	5.7	0.4	2.4	-0.5	0.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	12.8	-3.6	-0.1	-2.2	-0.2	-1.1
Age at first live birth	1.0	1.7	6.2	1.4	-0.3	0.4	-2.5	-0.2
Pulse wave peak to peak time	2.6	3.1	6.1	1.8	-0.7	2.5	0.9	2.2
Health satisfaction	0.1	0.2	0.5	0.7	-0.0	0.5	0.3	0.2
Shortness of breath walking on level ground	1.2	1.5	6.3	-0.5	-0.5	0.6	2.5	0.2
Qualifications: College or University degree	1.5	4.8	15.4	3.9	-1.4	1.7	-1.7	0.8
Eye problems/disorders: None of the above	1.4	1.7	7.0	2.6	-0.0	0.6	-0.2	0.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.4	-0.1	-0.2	-1.0	-1.1	-1.6
Emphysema/chronic bronchitis	0.9	1.0	3.1	-0.5	-0.0	-1.3	1.8	-0.0
Medication for pain relief, constipation, heartburn	0.8	1.4	4.0	2.0	-0.4	1.0	-1.2	0.7
Neck or shoulder pain in last month	0.6	0.9	3.6	-1.9	-0.5	-0.5	0.5	-0.4
Medication: Blood pressure	0.4	0.6	1.4	-0.3	1.0	-0.8	1.2	-0.3
Angina (self-reported)	1.7	2.2	5.6	-0.1	-1.0	1.2	2.4	1.7
Migraine (self-reported)	0.6	0.7	2.7	1.6	0.7	-0.6	-0.4	-0.1
Medication: Ibuprofen	0.3	0.3	0.7	0.7	0.1	0.8	0.1	0.6
Medication: Allopurinol	1.3	1.7	2.9	-0.6	1.7	-1.4	-0.9	-1.7
Medication: Omeprazole	0.7	0.9	2.1	-1.4	0.3	0.2	1.3	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.1	-0.1	-0.4	0.0	0.4
Mean time to correctly identify matches	0.9	1.6	2.1	-1.5	1.4	-1.1	-1.2	-1.2
Heart disease (mother)	0.6	0.8	1.3	0.2	1.1	0.9	0.7	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.4	0.7	-2.1	1.2	0.9	1.1
Whole body fat mass	0.5	1.9	3.1	-1.7	1.8	-1.0	1.1	-1.1
Leg fat mass (right)	0.4	1.5	3.1	-1.4	1.8	-0.8	0.7	-1.1
Arm predicted mass (right)	0.8	4.3	9.3	0.9	-0.2	2.9	1.8	3.0
Pulse rate, automated reading	0.5	1.7	4.6	1.2	2.2	0.8	-1.1	-0.5
Alcohol intake frequency.	0.1	0.1	0.2	-0.4	-0.0	-0.5	0.5	-0.1
Comparative height size at age 10	1.8	10.0	19.6	3.4	-1.7	3.7	1.6	4.4
Number of full sisters	1.1	1.3	2.3	-0.9	1.4	-1.5	0.6	-1.1
Suffer from ‘nerves’	0.7	1.2	2.4	-0.8	0.0	-1.3	-1.5	-1.1
Overall health rating	0.6	1.3	3.7	-0.7	0.8	-1.0	1.9	-0.7
Chest pain or discomfort	0.8	1.2	2.0	1.2	-1.4	0.8	0.8	1.1
Had major operations	1.0	1.2	3.0	-1.1	0.2	-0.6	-1.7	-1.1
Age at last live birth	0.7	1.0	3.2	0.3	-1.2	0.6	-1.8	0.1
Family relationship satisfaction	1.0	1.2	2.6	0.1	-0.3	1.1	1.5	1.6
Leg pain on walking	0.3	0.4	0.5	-0.5	0.7	-0.6	0.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	-0.2	0.5	-0.9	0.0	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.6	-0.2	-0.1	-1.3	0.4	-0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.4	-0.2	0.1	-0.8	0.7
Medication: Aspirin	2.2	2.9	12.2	-0.5	-1.3	-0.5	3.5	-0.5
Supplements: Vitamin C	2.7	3.1	14.5	0.2	-1.0	0.5	-3.8	0.2
Knee pain experienced in last month	0.1	0.2	0.9	-1.0	0.3	-0.0	-0.4	-0.1
Hypertension (Self-reported)	1.5	4.2	7.1	-2.2	0.9	-2.7	2.0	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.8	0.7	-0.2	1.5	0.8	2.6
Illnesses of father: Heart disease	1.7	2.4	7.3	-1.6	-0.7	-1.2	2.7	-0.4
Illnesses of siblings: Diabetes	0.3	0.3	1.1	-1.0	-0.1	-0.5	0.5	-0.3
Smoking status: Previous	0.5	0.7	1.0	-0.9	-0.4	-0.8	0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.3	1.0	-1.2	1.5	1.4	1.4
Whole body fat-free mass	0.5	3.0	7.3	0.5	-0.2	2.7	1.1	2.5
Leg fat-free mass (right)	0.1	0.7	1.5	-0.8	0.3	1.0	1.2	0.6
Arm fat percentage (left)	1.1	4.3	6.3	-2.5	2.2	-2.0	0.6	-2.4
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.5	0.5	-0.4	0.3
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.0	-0.5	-1.6	-0.9	-1.7	-0.8
Mood swings	0.5	0.9	2.1	0.5	-0.5	1.3	-0.4	1.4
Loneliness, isolation	0.4	0.5	1.6	1.3	0.3	0.6	-0.5	0.3
Long-standing illness, disability or infirmity	1.3	2.0	4.1	-2.0	0.5	-1.8	0.4	-1.6
Ever had bowel cancer screening	0.5	0.6	0.9	-0.3	0.6	0.8	-0.9	1.0
Diabetes diagnosed by doctor	0.8	1.4	3.6	-0.9	0.8	-0.9	-0.9	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.0	-0.6	-0.3	-0.5	0.2	-1.4
Friendships satisfaction	2.4	3.0	8.2	1.0	-0.8	2.9	-0.1	2.3
Qualifications: nursing, teaching	0.7	1.0	2.2	-0.1	-0.7	-0.7	-1.5	-1.4
Commuting to job workplace: Walk	1.7	1.8	5.3	-0.2	-2.3	1.1	0.6	1.4
Eye problems/disorders: Cataract	0.8	0.9	3.6	-1.9	0.2	-0.3	0.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	-0.6	0.4	0.8	0.9	0.6
Medication for cholesterol	1.9	2.9	5.5	1.8	0.1	2.3	-1.0	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-0.3	-1.4	-0.9	0.1	-1.0
Back pain experienced in last month	0.5	0.7	1.7	-1.3	-0.1	0.2	-1.1	0.6
Mineral and other dietary supplements	1.9	2.6	5.8	-1.4	1.9	-1.0	2.4	-0.5
Breast cancer (self-reported)	2.0	2.4	9.0	-1.6	0.3	0.2	-3.0	-0.4
Asthma (self-reported)	0.1	0.2	0.4	0.2	0.6	-0.5	-0.4	0.3
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.1	0.6	0.5	0.6	1.2
Osteoarthritis (self-reported)	1.3	1.6	6.9	-2.6	-0.0	-0.8	-0.1	-0.8
Medication: Aspirin	2.0	2.6	10.3	-0.7	-1.3	-0.5	3.2	-0.4
Medication: Gliclazide	0.7	0.8	2.1	-0.1	0.9	-1.0	-0.6	-1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	0.3	0.7	0.9	-0.2	1.3
Smoking status: Current	0.8	1.2	3.1	-1.8	0.6	0.9	-0.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.1	1.0	-0.8	1.0	0.5	1.5
Whole body water mass	0.5	2.9	6.9	0.5	-0.3	2.6	1.2	2.4
Leg predicted mass (right)	0.1	0.7	1.5	-0.7	0.4	1.1	1.2	0.6
Arm fat mass (left)	0.6	2.3	4.3	-2.1	1.9	-1.1	0.9	-1.2
Number of self-reported non-cancer illnesses	0.8	1.4	2.9	-1.5	-0.1	-1.7	0.9	-1.0
Average weekly champagne plus white wine intake	0.4	0.5	1.2	1.1	0.7	-0.0	1.0	-0.2
Miserableness	0.5	0.8	1.2	1.0	0.9	1.1	-0.6	0.8
Guilty feelings	0.5	0.7	2.1	1.4	-0.1	0.8	-1.0	-0.2
Wears glasses or contact lenses	0.6	0.7	3.1	-0.7	0.3	0.1	1.8	0.1
Ever taken oral contraceptive pill	0.2	0.3	0.7	-0.1	-0.8	-0.4	0.3	-0.5
Hearing aid user	0.5	0.6	1.5	0.1	1.0	1.2	0.6	0.5
Mother’s age at death	1.0	1.2	2.2	1.1	-0.5	1.2	-0.9	1.5
Financial situation satisfaction	2.7	3.4	11.0	3.3	1.2	1.2	1.2	1.3
Tinnitus: Yes, now most or all of the time	2.6	3.1	6.2	-2.5	1.8	-0.8	2.3	-0.6
Commuting to job workplace: Public transport	1.5	1.8	4.4	-0.7	-1.7	1.0	-2.1	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.2	-1.0	0.7	0.8	-0.1
Medication: Blood pressure	3.1	5.9	13.5	-2.2	0.0	-3.7	0.6	-3.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.7	-0.7	-1.3	0.3	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	1.3	1.8	4.2	1.0	-2.0	1.0	-0.8	1.4
High cholesterol (Self-reported)	0.8	1.4	4.5	-1.4	-0.1	-0.6	2.1	0.2
Medication: Bendroflumethiazide	2.7	4.1	7.6	-2.8	0.6	-2.5	1.9	-1.6
Medication: Paracetamol	0.5	0.7	1.8	-1.0	1.3	0.1	0.8	0.5
Medication: Lisinopril	0.8	1.1	2.7	0.5	0.9	-0.8	-1.6	-0.9
Medication: Atorvastatin	0.7	0.8	1.3	0.9	-0.9	0.9	0.6	1.1
Illnesses of father: High blood pressure	1.3	1.6	3.7	1.9	-1.4	1.1	0.9	0.2
Alcohol drinker status: Never	2.1	2.5	7.8	0.4	-2.8	1.5	-1.3	0.8
Ever smoked	1.0	1.7	3.0	-1.7	-1.7	1.0	1.1	0.6
Basal metabolic rate	0.4	2.0	4.8	0.2	0.0	2.2	1.1	1.9
Leg fat percentage (left)	0.9	3.4	4.7	-2.1	2.2	-1.7	1.4	-1.7
Arm fat-free mass (left)	0.7	3.3	7.2	0.5	-0.3	2.6	1.5	2.7
Number of operations (self-reported)	0.2	0.2	0.6	-0.6	-0.1	-0.4	0.1	-0.8
Average weekly beer plus cider intake	0.3	0.4	1.5	0.5	-1.2	0.6	-0.1	0.2
Irritability	1.3	2.2	3.6	0.2	-1.5	1.6	1.6	1.9
Risk taking	0.6	0.9	1.6	-1.0	1.3	-0.9	0.2	-1.0
Ever had prostate specific antigen (PSA) test	6.0	6.9	12.7	2.2	-2.1	3.6	1.0	3.4
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.9	0.2	-0.2	0.7	1.0
Age started oral contraceptive pill	0.4	0.6	1.5	0.7	-1.2	-0.7	-0.3	-0.5
Diastolic blood pressure, automated reading	0.2	0.7	2.2	-0.2	0.5	0.4	1.5	0.9
Ever depressed for a whole week	0.7	0.9	2.9	0.2	-0.3	0.9	0.7	1.7
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.1	0.9	-0.8	0.0	-0.8
Commuting to job workplace: Cycle	1.2	1.4	3.5	-0.0	-1.1	1.9	0.4	1.5
Myopia	1.3	1.9	6.9	1.3	-2.6	-0.2	-0.5	-0.7
Vascular/heart problems diagnosed by doctor	1.0	2.8	8.2	1.6	-0.2	1.6	-2.9	0.9
Cholesterol lowering medication	0.4	0.6	1.3	-0.6	-0.4	-1.1	0.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	-1.2	-0.1	0.2	1.1	0.1
Pain experienced in last month	0.9	1.4	3.0	0.7	-0.3	-1.7	1.1	-1.6
Supplements: Calcium	0.4	0.4	1.0	-0.1	0.9	0.1	-1.0	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	-1.1	0.5	-0.3	-0.7	-0.1
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.2	-0.4	-0.4	0.9	2.0	1.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.0	0.1	0.8	-0.9	-0.5	-1.7
Heart disease (siblings)	0.3	0.4	1.1	-1.0	0.5	-0.1	-0.5	0.4
Alcohol drinker status: Previous	0.6	0.6	1.8	-0.5	1.3	-0.1	0.8	0.7
Pack years of smoking	0.9	1.4	2.7	-1.2	0.1	-1.6	-0.7	-1.5
Impedance of whole body	0.1	0.5	2.1	1.4	-0.1	-0.4	-0.6	0.0
Leg fat mass (left)	0.5	1.8	3.6	-1.5	1.9	-0.9	1.2	-1.1
Arm predicted mass (left)	0.7	3.4	7.2	0.8	-0.3	2.7	1.4	2.7