Hub : Genes

OSGIN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Not Sun Exposed Suprapubic 0.2160 0.0760 0.00480 0.017 NA 0.027 NA 0.023 3.9e-02 NA 1.3e-02 NA 1.9e-02
2 YFS Blood 0.0450 0.0154 0.00031 0.001 0.013 0.012 0.014 0.004 1.9e-01 2.9e-05 6.8e-05 1.3e-05 1.4e-02
3 TCGA Brain Lower Grade Glioma 0.0374 0.0183 0.00940 0.014 0.020 0.014 NA 0.010 8.3e-03 2.2e-03 7.9e-03 NA 2.1e-02
4 TCGA Pancreatic Adenocarcinoma 0.1830 0.0690 0.00260 -0.001 0.059 0.004 NA 0.013 3.6e-01 1.7e-03 2.1e-01 NA 9.0e-02
5 TCGA Prostate Adenocarcinoma 0.2843 0.0474 0.00000 0.327 0.327 0.345 NA 0.333 5.7e-35 4.4e-35 3.0e-37 NA 8.0e-36

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.7 1.0 2.3 -0.2 1.5 -1.3 -0.7 -0.8
Bipolar Disorder or Schizophrenia 1.2 3.0 4.6 -0.9 1.8 -2.1 -1.6 -2.0
Depressed Affect (Nagel 2018) 0.3 0.6 2.2 1.5 0.4 0.5 -0.4 0.4
Depression (Nagel 2018) 0.7 1.1 2.7 1.0 -1.0 1.7 0.2 0.8
Intelligence (Savage-Jansen 2018) 1.2 3.6 11.5 3.4 -0.6 1.9 -1.1 1.3
Neuroticism (Nagel 2018) 0.6 1.3 2.4 1.2 -0.9 1.3 -0.6 1.6
Schizophrenia (2018) 1.0 2.2 3.7 -0.9 1.0 -1.7 -1.6 -1.9
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 0.5 -0.3 0.3 -0.0 0.2
Worry (Nagel 2018) 0.4 0.8 1.7 -0.1 -1.3 0.1 -0.7 1.3
Alzheimer’s Disease (in mother) 0.3 0.3 0.9 0.0 0.6 -0.9 -0.7 -0.2
Alzheimer’s Disease (in father) 1.0 1.1 4.8 2.2 -0.0 0.1 -0.7 -0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 1.5 0.7 1.2 -1.0 -1.0 -1.0
Crohns Disease (2017) 0.5 1.0 2.9 -1.2 -0.3 -1.7 0.0 -0.9
Irritable Bowel Disease (IBD) 0.1 0.3 1.0 -0.3 -0.6 -1.0 -0.5 0.0
Ulcerative Colitis (UC) 0.2 0.5 1.3 0.8 -0.3 0.4 0.2 1.1
Major Depression (MDD) 0.0 0.0 0.0 -0.1 0.2 0.0 0.0 0.0
Reaction Time 1.1 2.1 5.0 -1.7 2.2 -0.6 -0.9 -1.2
Verbal and Numeric Reasoning (VNR) 1.1 2.7 8.1 2.9 -0.2 1.5 -1.4 1.0
Breast Cancer 0.1 0.3 1.1 0.1 -1.0 0.2 0.4 0.2
Ovarian Cancer 0.5 0.7 1.2 -0.5 -0.2 -1.0 -1.1 -0.9
Prostate Cancer 0.5 0.7 1.6 -0.9 0.4 -1.3 0.5 -0.9
Age at First Birth 1.1 1.6 5.5 2.3 -0.9 -0.1 -0.1 1.4
Bipolar Disorder (2011) 0.5 0.5 2.4 0.0 1.5 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 3.1 4.2 6.3 -2.4 2.5 -1.5 -1.2 -2.3
Coronary Artery Disease (CAD) 2.2 2.6 6.9 1.9 -1.1 1.1 2.6 0.0
Crohns Disease (2012) 1.2 2.0 6.1 -0.4 -0.2 -1.7 2.5 -0.9
Mean Putamen Volume 2.1 2.4 4.4 1.6 -1.4 1.7 -0.4 2.1
Fasting Glucose 0.7 0.9 2.7 0.4 1.6 -0.6 -0.8 -0.7
HbA1C 0.7 0.8 2.1 0.8 -1.5 -0.9 -0.2 -0.6
HDL Cholesterol 0.6 1.0 2.8 -0.5 -1.4 0.1 1.7 0.4
LDL Cholesterol 0.7 1.0 3.3 -1.0 -0.6 0.5 1.8 0.5
Lupus 0.4 0.6 1.9 1.4 0.6 -0.6 -0.4 -0.8
Neuroticism (2016) 1.5 2.1 3.4 1.8 -1.5 1.7 0.3 1.4
Primary Biliary Cirrhosis 0.2 0.3 1.0 -0.4 1.0 -0.3 -0.0 -0.4
Rheumatoid Arthritis 0.5 0.6 1.8 0.1 1.1 0.5 0.1 1.3
Schizophrenia (2014) 1.1 2.5 6.0 -1.5 1.3 -1.3 -2.4 -0.9
Triglycerides 0.4 0.7 2.7 -1.6 0.7 -0.1 0.2 0.2
Type 2 Diabetes (T2D) (2012) 2.0 2.3 2.9 1.6 1.5 -1.7 -1.2 -1.6
Ulcerative Colitis 1.0 1.5 3.1 1.2 -1.1 1.0 0.8 1.8
Blood Eosinophil Count 0.1 0.5 0.7 -0.7 0.8 -0.4 -0.8 -0.8
Blood Platelet Count 0.5 5.9 13.7 0.6 -1.5 2.4 2.7 3.7
Blood Red Count 1.0 10.1 21.6 -1.3 2.3 -4.1 -2.3 -4.7
Blood White Count 0.2 1.2 4.5 -2.1 0.8 -0.5 -0.0 -0.8
Heel T-Score 0.0 0.3 0.8 -0.3 0.2 -0.9 0.2 -0.9
BMI 0.3 1.5 2.8 -1.2 1.7 -0.8 0.7 -1.5
Height 0.9 16.8 39.8 3.7 -0.7 5.2 1.8 6.3
Waist Hip Ratio (WHR) 0.4 1.8 2.9 -1.0 -0.6 1.4 1.6 1.7
Systolic Blood Pressure 0.1 0.6 1.5 0.1 0.0 -1.2 0.6 -0.9
Smoking Status 0.3 0.6 1.2 -0.9 0.2 0.9 0.2 1.1
Allergy or Eczema 0.9 2.3 4.5 0.5 -1.2 2.1 -1.7 1.5
Cardiovascular Disease 0.7 2.1 7.1 -0.5 0.2 -1.5 2.7 -1.1
Hypothyroidism (self reported) 0.7 1.7 2.8 -1.6 -1.1 -1.7 1.3 -0.4
Respiratory disease 0.2 0.5 1.0 -0.9 0.3 -0.7 -1.0 0.3
Type 2 Diabetes (T2D) (2018) 0.1 0.3 0.9 -0.0 -0.1 0.6 0.3 -0.9
Lung FEV1/FVC ratio 0.2 1.0 2.0 -0.2 -1.2 1.4 0.4 1.2
Lung FVC 0.0 0.2 0.5 0.4 0.7 -0.5 0.2 -0.5
Neuroticism 0.4 0.9 1.3 0.6 -0.6 1.1 -1.0 1.1
Chronotype (morning person) 0.3 0.7 2.7 -0.6 0.2 -1.6 0.3 -0.5
Hair Pigment 0.1 2.4 4.1 -1.1 2.0 -1.8 -0.9 -1.6
Tanning 0.1 1.1 2.2 1.0 0.4 -0.1 -1.5 -1.5
Hand grip strength (left) 1.1 3.0 6.0 1.8 -1.3 2.4 0.1 2.0
Number of treatments/medications taken 1.6 2.8 6.4 -1.6 0.1 -2.5 1.1 -2.0
Average weekly spirits intake 0.8 1.0 1.9 0.2 1.3 -1.4 1.0 -0.5
Sensitivity / hurt feelings 1.9 3.3 6.6 1.0 -1.2 2.6 -2.2 1.5
Frequency of depressed mood in last 2 weeks 1.4 1.9 4.3 1.8 -1.0 2.1 -0.3 1.1
Hearing difficulty/problems: Yes 0.3 0.5 1.7 -1.3 -0.4 0.6 -0.0 0.4
Relative age of first facial hair 0.3 0.6 2.2 -0.4 -0.4 0.5 1.5 0.2
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.2 -1.3 0.5 -1.5 1.1 -1.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.9 0.1 -0.8 0.8 -0.5 0.9
Ever had hysterectomy (womb removed) 0.5 0.5 0.9 -0.9 0.5 0.9 0.3 -0.9
Systolic blood pressure, automated reading 0.1 0.4 1.3 0.2 -0.4 -0.5 1.2 0.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.3 -0.9 -1.5 0.4 0.7 0.0
Angina 1.7 2.3 5.0 -0.2 -1.1 1.3 2.2 1.9
Medication for hormone replacement therapy 0.4 0.5 1.5 0.2 -0.5 1.2 0.2 0.8
Vitamin and mineral supplements 1.4 2.0 3.0 -1.7 -0.1 -1.5 1.5 -1.5
Supplements: Zinc 1.2 1.3 3.1 -0.1 0.1 1.8 -1.0 1.6
Medication: Co-codamol 0.9 1.1 2.6 -1.4 0.1 -0.9 1.6 -0.4
Medication: Metformin 1.1 1.6 4.7 -1.1 0.3 -1.4 0.0 -2.2
Diabetes (father) 0.3 0.3 1.0 -1.0 0.1 -0.6 0.3 -0.3
Diabetes (mother) 1.1 1.4 2.7 -1.2 0.5 -1.7 -0.4 -1.6
Severe depression (siblings) 0.9 1.0 3.5 -1.9 -0.3 -0.8 0.7 -0.7
Pack years adult smoking proportion 1.0 1.5 3.0 -0.9 0.1 -1.7 -1.0 -1.7
Impedance of leg (right) 0.5 2.5 7.2 2.7 -0.3 1.1 -1.0 1.7
Leg fat-free mass (left) 0.1 0.6 1.3 -0.4 0.3 1.1 0.9 0.6
Trunk fat percentage 0.8 3.1 4.0 -2.0 2.0 -1.7 1.2 -1.8
Hand grip strength (right) 2.6 7.1 12.1 3.1 -0.0 3.4 1.4 3.5
Townsend deprivation index at recruitment 0.5 0.7 2.7 0.1 -1.6 -0.4 -0.7 -0.1
Current tobacco smoking 0.6 1.0 2.4 -1.5 0.9 0.8 -0.6 0.9
Average weekly fortified wine intake 0.8 0.9 1.9 0.7 1.4 -1.1 -1.0 -0.1
Maternal smoking around birth 2.2 3.1 9.0 -3.0 -0.4 -0.4 2.5 -0.1
Fed-up feelings 0.5 0.9 1.9 1.4 -0.4 1.1 0.2 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 4.8 1.4 -1.4 2.2 0.3 1.9
Relative age voice broke 0.3 0.5 1.1 0.2 0.3 0.7 -1.0 -0.9
Taking other prescription medications 1.1 1.7 4.7 -2.2 -0.7 -1.4 -0.3 -1.2
Age when periods started (menarche) 1.6 3.9 8.8 3.0 -1.2 1.6 1.9 1.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.6 -0.4 0.4 0.6 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.0 -1.0 0.5 -0.2 0.3 0.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.8 1.3 0.7 -0.2 -1.9 -0.8
Qualifications: CSEs or equivalent 0.4 0.5 0.8 -0.9 -0.8 0.4 -0.9 -0.4
Serious illness, injury or assault to yourself 0.3 0.3 0.6 0.4 0.8 -0.4 0.0 -0.8
High blood pressure 1.3 3.7 5.0 -2.2 0.9 -2.2 2.2 -1.8
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.7 0.6 -1.0 1.9 -1.4 1.3
Multivitamins +/- minerals 1.4 1.8 3.1 1.6 -0.5 1.7 -0.3 1.8
Stomach or abdominal pain in last month 1.0 1.2 3.2 -0.8 -0.4 0.7 1.8 1.3
Supplements: Glucosamine 2.7 3.5 11.4 1.4 -1.6 1.1 -3.4 0.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 0.2 -0.2 0.6 0.9 0.8
Medication: Atenolol 0.3 0.4 0.8 0.0 -0.7 0.0 0.9 0.7
Medication: Levothyroxine sodium 1.1 1.9 4.0 -2.0 -0.1 -2.0 0.8 -1.1
Sitting height 0.9 6.7 13.2 2.6 -0.4 3.4 1.4 3.6
Chronic bronchitis/emphysema (father) 2.0 2.3 4.6 -2.0 -0.7 -1.5 -0.5 -2.2
High blood pressure (mother) 0.4 0.5 1.1 0.6 0.6 0.5 -1.0 -0.8
Body mass index (BMI) 0.7 3.1 6.0 -2.4 1.8 -1.5 0.6 -1.9
Impedance of leg (left) 0.4 1.7 4.9 2.2 -0.0 0.9 0.2 1.6
Leg predicted mass (left) 0.1 0.5 1.3 -0.4 0.3 1.1 0.9 0.6
Trunk fat mass 0.4 1.9 3.3 -1.6 1.8 -0.9 1.3 -1.0
Waist circumference 0.5 1.7 3.8 -2.0 1.0 -1.0 1.3 -1.1
Number of incorrect matches in round 0.5 0.8 2.0 -0.7 -1.4 -1.1 -0.1 -0.4
Past tobacco smoking 0.8 1.4 2.7 1.6 1.3 0.2 -1.6 0.4
Alcohol usually taken with meals 0.6 0.9 4.0 2.0 0.3 0.5 0.3 -0.4
Nervous feelings 0.2 0.3 0.9 -0.4 -0.9 -0.1 -0.6 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.0 0.0 -0.8 1.0 0.1 0.8
Hearing difficulty/problems with background noise 0.4 0.6 2.7 -1.6 -0.2 -0.3 -0.4 -0.2
Hair/balding pattern: Pattern 2 2.1 2.6 5.1 0.6 -1.3 2.0 -1.4 2.3
Had menopause 0.8 1.0 2.5 1.0 -1.6 -0.4 -1.2 0.1
Had other major operations 0.6 0.8 1.0 -1.0 1.0 -0.8 1.0 -0.5
Forced vital capacity (FVC) 1.5 5.8 11.0 2.5 -1.0 3.3 0.8 3.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.8 -1.3 1.1 -0.5 1.1 -0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.5 0.6 0.1 1.2 0.4 1.1
Qualifications: None of the above 0.9 1.8 3.5 -1.8 -0.9 -1.2 1.9 0.2
Financial difficulties in last 2 years 0.7 1.0 1.6 1.0 -1.0 1.1 0.1 1.3
Mouth/teeth dental problems 0.5 0.8 2.2 1.4 0.2 0.2 -1.5 -0.0
Heart attack 1.5 1.9 5.3 0.0 -0.7 1.2 2.3 1.5
Allergy 0.4 0.9 1.7 -0.2 0.8 -1.1 1.3 -0.8
Pain all over the body in last month 0.5 0.5 0.9 0.1 0.9 0.6 0.9 0.6
Diabetes (self-reported) 0.5 0.8 3.0 -0.4 0.5 -0.7 -0.5 -1.7
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 4.1 -0.6 -2.0 -0.4 -1.5 -0.6
Medication: Ramipril 2.8 3.5 9.2 -3.0 1.2 -1.0 2.2 -1.1
Medication: Simvastatin 2.3 3.4 5.0 -2.2 0.7 -2.0 2.1 -1.9
Fluid intelligence score 2.0 4.2 8.5 2.9 0.0 2.5 -0.3 2.4
Illnesses of siblings 0.4 0.5 2.2 -0.6 -0.2 -0.2 -1.5 0.1
Neuroticism score 0.5 1.0 1.7 0.6 -0.3 1.2 -1.3 1.1
Weight 0.2 0.8 1.4 -1.2 1.1 0.3 1.1 0.2
Impedance of arm (right) 0.3 1.2 2.3 0.3 -0.4 -1.2 -1.5 -1.5
Arm fat percentage (right) 1.1 4.2 6.2 -2.5 2.0 -2.1 0.3 -2.5
Trunk fat-free mass 1.0 5.7 12.7 1.3 -0.7 3.5 0.9 3.6
Hip circumference 0.2 0.8 1.2 -1.1 1.1 -0.6 0.5 -1.0
Time employed in main current job 1.5 1.7 3.3 -1.8 1.3 -0.5 -1.8 0.3
Alcohol intake versus 10 years previously 1.1 1.7 4.8 0.7 -0.9 1.1 1.2 2.2
Father’s age at death 0.6 0.8 2.9 0.5 -1.7 -0.3 -0.7 0.3
Worrier / anxious feelings 0.4 0.8 2.4 0.6 -0.5 0.8 -0.7 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.5 -1.2 -0.7 1.2 0.9 0.7
Falls in the last year 0.7 1.0 1.7 -0.4 1.2 -1.3 -0.3 -1.2
Hair/balding pattern: Pattern 3 1.1 1.6 5.1 -2.3 0.2 -1.6 0.1 -0.6
Number of live births 1.1 1.6 5.0 -1.1 1.0 -0.7 2.2 -0.6
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 10.0 2.6 -0.7 3.2 0.7 2.5
Pulse rate 0.3 0.5 1.0 0.1 1.0 -0.8 -0.9 -0.5
Happiness 1.2 1.5 3.6 1.4 -0.0 1.9 0.6 1.1
Noisy workplace 1.8 2.2 3.6 -1.9 1.4 -1.6 -0.1 -1.8
Qualifications: A levels/AS levels or equivalent 0.6 1.2 1.8 1.3 -1.1 0.6 -1.4 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.0 0.3 0.3 0.2 1.0 -0.6
Mouth/teeth dental problems: Dentures 0.6 1.0 2.9 -1.7 0.1 -0.5 1.3 0.1
Asthma 0.1 0.2 0.3 0.6 0.5 -0.2 -0.3 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.5 0.3 0.7 0.6 0.5 0.7
Medication: Cholesterol lowering 1.3 2.0 8.8 -0.4 0.7 0.0 3.0 0.8
Depression (self-reported) 0.9 1.1 2.6 0.1 1.6 -0.3 -1.1 -1.2
Medication: Lansoprazole 0.7 0.8 2.0 -1.3 -0.1 0.3 -1.4 0.3
Prospective memory result 0.6 0.7 2.1 -0.5 1.5 -0.7 -0.6 -0.6
Lung cancer (father) 0.7 0.9 1.4 -0.5 1.1 1.1 -0.6 1.2
Illnesses of mother 0.1 0.1 0.3 -0.2 -0.4 -0.0 -0.6 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 7.2 1.8 0.1 2.7 0.1 2.1
Pulse wave Arterial Stiffness index 1.7 2.0 4.2 -1.4 0.6 -2.1 -0.9 -1.7
Impedance of arm (left) 0.1 0.7 1.1 0.5 -0.3 -1.0 -0.9 -1.1
Arm fat mass (right) 0.5 2.1 3.3 -1.8 1.8 -1.2 0.7 -1.4
Trunk predicted mass 1.0 5.5 12.6 1.2 -0.7 3.4 0.9 3.5
Standing height 1.0 10.3 22.9 2.9 -1.4 4.2 0.9 4.8
Length of working week for main job 0.5 0.6 1.6 -0.7 0.4 -0.6 0.6 -1.3
Exposure to tobacco smoke at home 2.9 3.3 5.5 -0.7 -2.2 0.9 2.2 2.4
Breastfed as a baby 0.8 1.0 2.4 -0.4 1.1 -1.5 -0.0 -1.2
Tense / ‘highly strung’ 1.2 2.0 6.6 -2.6 -1.2 -0.4 1.2 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.5 0.9 0.1 -0.7 0.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 0.8 0.6 0.3 -0.4 -0.3
Birth weight of first child 0.7 1.2 3.0 -1.7 0.8 -0.3 1.5 -0.0
Peak expiratory flow (PEF) 1.4 3.4 7.1 2.7 -0.2 2.7 -0.4 1.6
Pulse wave reflection index 1.1 1.4 2.3 -0.9 -0.5 -1.2 -1.5 -1.5
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 0.9 0.2 0.5 -0.3 -0.1
Loud music exposure frequency 2.1 2.3 7.7 -0.4 2.8 -1.1 0.8 -1.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 2.2 0.7 -1.4 0.6 -1.5 -0.9
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.8 -0.6 1.3 -0.7 0.8 -0.7
Blood clot in the leg (DVT) 0.4 0.5 1.9 0.2 0.7 -0.5 -0.2 -1.4
Medication: Paracetamol 0.6 1.0 2.7 -1.6 1.3 -0.4 0.2 0.4
Headache pain in last month 1.5 2.5 7.3 1.7 -0.1 1.6 0.0 2.7
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 7.3 -0.3 -0.6 -0.3 -2.7 -0.8
Glaucoma (self-reported) 0.4 0.5 1.3 -0.7 -1.1 0.5 0.7 -0.2
Gout (self-reported) 2.2 3.0 6.5 -1.9 2.5 -1.6 -0.4 -1.6
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 5.5 -2.3 -0.7 -1.7 1.2 -0.2
Medication: Amlodipine 0.8 1.2 3.3 -0.6 0.6 -1.8 -0.4 -1.2
Medication: Ventolin 100micrograms inhaler 1.7 2.2 8.5 0.8 1.3 -0.1 -2.9 -0.3
Birth weight 1.9 4.2 10.9 0.3 -1.3 3.3 -0.6 2.8
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.9 -0.0 -1.2 1.7 0.2 1.3
High blood pressure (siblings) 0.8 1.2 2.8 -0.1 0.3 -1.0 1.4 -1.7
Forced vital capacity (FVC), Best measure 0.9 3.2 7.0 1.8 0.1 2.6 0.1 2.4
Body fat percentage 0.9 3.4 4.7 -2.2 2.1 -1.8 1.1 -1.9
Leg fat percentage (right) 0.6 2.2 3.6 -1.6 1.9 -1.4 0.7 -1.6
Arm fat-free mass (right) 0.8 4.0 9.0 0.7 -0.2 2.6 1.9 3.0
Exposure to tobacco smoke outside home 0.8 1.1 2.3 -0.4 -0.5 -1.5 1.5 -0.7
Comparative body size at age 10 0.3 0.7 1.9 -0.4 -0.2 -1.1 0.4 -1.4
Number of full brothers 0.8 1.1 2.7 -0.5 1.6 1.3 -0.7 0.2
Worry too long after embarrassment 1.0 1.7 2.2 1.2 -1.5 1.4 -0.9 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.6 0.4 -0.3 -0.6 -0.7
Wheeze or whistling in the chest in last year 0.3 0.6 1.1 0.6 0.2 0.8 -1.0 1.1
Number of children fathered 1.2 1.3 5.7 0.4 2.4 -0.5 0.4 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 3.2 3.7 12.8 -3.6 -0.1 -2.2 -0.2 -1.1
Age at first live birth 1.0 1.7 6.2 1.4 -0.3 0.4 -2.5 -0.2
Pulse wave peak to peak time 2.6 3.1 6.1 1.8 -0.7 2.5 0.9 2.2
Health satisfaction 0.1 0.2 0.5 0.7 -0.0 0.5 0.3 0.2
Shortness of breath walking on level ground 1.2 1.5 6.3 -0.5 -0.5 0.6 2.5 0.2
Qualifications: College or University degree 1.5 4.8 15.4 3.9 -1.4 1.7 -1.7 0.8
Eye problems/disorders: None of the above 1.4 1.7 7.0 2.6 -0.0 0.6 -0.2 0.9
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.4 -0.1 -0.2 -1.0 -1.1 -1.6
Emphysema/chronic bronchitis 0.9 1.0 3.1 -0.5 -0.0 -1.3 1.8 -0.0
Medication for pain relief, constipation, heartburn 0.8 1.4 4.0 2.0 -0.4 1.0 -1.2 0.7
Neck or shoulder pain in last month 0.6 0.9 3.6 -1.9 -0.5 -0.5 0.5 -0.4
Medication: Blood pressure 0.4 0.6 1.4 -0.3 1.0 -0.8 1.2 -0.3
Angina (self-reported) 1.7 2.2 5.6 -0.1 -1.0 1.2 2.4 1.7
Migraine (self-reported) 0.6 0.7 2.7 1.6 0.7 -0.6 -0.4 -0.1
Medication: Ibuprofen 0.3 0.3 0.7 0.7 0.1 0.8 0.1 0.6
Medication: Allopurinol 1.3 1.7 2.9 -0.6 1.7 -1.4 -0.9 -1.7
Medication: Omeprazole 0.7 0.9 2.1 -1.4 0.3 0.2 1.3 0.5
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.1 -0.1 -0.4 0.0 0.4
Mean time to correctly identify matches 0.9 1.6 2.1 -1.5 1.4 -1.1 -1.2 -1.2
Heart disease (mother) 0.6 0.8 1.3 0.2 1.1 0.9 0.7 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 4.4 0.7 -2.1 1.2 0.9 1.1
Whole body fat mass 0.5 1.9 3.1 -1.7 1.8 -1.0 1.1 -1.1
Leg fat mass (right) 0.4 1.5 3.1 -1.4 1.8 -0.8 0.7 -1.1
Arm predicted mass (right) 0.8 4.3 9.3 0.9 -0.2 2.9 1.8 3.0
Pulse rate, automated reading 0.5 1.7 4.6 1.2 2.2 0.8 -1.1 -0.5
Alcohol intake frequency. 0.1 0.1 0.2 -0.4 -0.0 -0.5 0.5 -0.1
Comparative height size at age 10 1.8 10.0 19.6 3.4 -1.7 3.7 1.6 4.4
Number of full sisters 1.1 1.3 2.3 -0.9 1.4 -1.5 0.6 -1.1
Suffer from ‘nerves’ 0.7 1.2 2.4 -0.8 0.0 -1.3 -1.5 -1.1
Overall health rating 0.6 1.3 3.7 -0.7 0.8 -1.0 1.9 -0.7
Chest pain or discomfort 0.8 1.2 2.0 1.2 -1.4 0.8 0.8 1.1
Had major operations 1.0 1.2 3.0 -1.1 0.2 -0.6 -1.7 -1.1
Age at last live birth 0.7 1.0 3.2 0.3 -1.2 0.6 -1.8 0.1
Family relationship satisfaction 1.0 1.2 2.6 0.1 -0.3 1.1 1.5 1.6
Leg pain on walking 0.3 0.4 0.5 -0.5 0.7 -0.6 0.5 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.8 -0.2 0.5 -0.9 0.0 -0.9
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.6 -0.2 -0.1 -1.3 0.4 -0.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.7 -0.4 -0.2 0.1 -0.8 0.7
Medication: Aspirin 2.2 2.9 12.2 -0.5 -1.3 -0.5 3.5 -0.5
Supplements: Vitamin C 2.7 3.1 14.5 0.2 -1.0 0.5 -3.8 0.2
Knee pain experienced in last month 0.1 0.2 0.9 -1.0 0.3 -0.0 -0.4 -0.1
Hypertension (Self-reported) 1.5 4.2 7.1 -2.2 0.9 -2.7 2.0 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 6.8 0.7 -0.2 1.5 0.8 2.6
Illnesses of father: Heart disease 1.7 2.4 7.3 -1.6 -0.7 -1.2 2.7 -0.4
Illnesses of siblings: Diabetes 0.3 0.3 1.1 -1.0 -0.1 -0.5 0.5 -0.3
Smoking status: Previous 0.5 0.7 1.0 -0.9 -0.4 -0.8 0.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 2.3 1.0 -1.2 1.5 1.4 1.4
Whole body fat-free mass 0.5 3.0 7.3 0.5 -0.2 2.7 1.1 2.5
Leg fat-free mass (right) 0.1 0.7 1.5 -0.8 0.3 1.0 1.2 0.6
Arm fat percentage (left) 1.1 4.3 6.3 -2.5 2.2 -2.0 0.6 -2.4
Average weekly red wine intake 0.2 0.3 0.5 0.7 0.5 0.5 -0.4 0.3
Handedness (chirality/laterality): Left-handed 1.2 1.5 3.0 -0.5 -1.6 -0.9 -1.7 -0.8
Mood swings 0.5 0.9 2.1 0.5 -0.5 1.3 -0.4 1.4
Loneliness, isolation 0.4 0.5 1.6 1.3 0.3 0.6 -0.5 0.3
Long-standing illness, disability or infirmity 1.3 2.0 4.1 -2.0 0.5 -1.8 0.4 -1.6
Ever had bowel cancer screening 0.5 0.6 0.9 -0.3 0.6 0.8 -0.9 1.0
Diabetes diagnosed by doctor 0.8 1.4 3.6 -0.9 0.8 -0.9 -0.9 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.0 -0.6 -0.3 -0.5 0.2 -1.4
Friendships satisfaction 2.4 3.0 8.2 1.0 -0.8 2.9 -0.1 2.3
Qualifications: nursing, teaching 0.7 1.0 2.2 -0.1 -0.7 -0.7 -1.5 -1.4
Commuting to job workplace: Walk 1.7 1.8 5.3 -0.2 -2.3 1.1 0.6 1.4
Eye problems/disorders: Cataract 0.8 0.9 3.6 -1.9 0.2 -0.3 0.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.7 -0.6 0.4 0.8 0.9 0.6
Medication for cholesterol 1.9 2.9 5.5 1.8 0.1 2.3 -1.0 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.8 -0.3 -1.4 -0.9 0.1 -1.0
Back pain experienced in last month 0.5 0.7 1.7 -1.3 -0.1 0.2 -1.1 0.6
Mineral and other dietary supplements 1.9 2.6 5.8 -1.4 1.9 -1.0 2.4 -0.5
Breast cancer (self-reported) 2.0 2.4 9.0 -1.6 0.3 0.2 -3.0 -0.4
Asthma (self-reported) 0.1 0.2 0.4 0.2 0.6 -0.5 -0.4 0.3
Osteoporosis (self-reported) 0.4 0.5 1.4 -0.1 0.6 0.5 0.6 1.2
Osteoarthritis (self-reported) 1.3 1.6 6.9 -2.6 -0.0 -0.8 -0.1 -0.8
Medication: Aspirin 2.0 2.6 10.3 -0.7 -1.3 -0.5 3.2 -0.4
Medication: Gliclazide 0.7 0.8 2.1 -0.1 0.9 -1.0 -0.6 -1.4
Illnesses of father: None of the above (group 1) 0.5 0.6 1.7 0.3 0.7 0.9 -0.2 1.3
Smoking status: Current 0.8 1.2 3.1 -1.8 0.6 0.9 -0.1 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.1 1.0 -0.8 1.0 0.5 1.5
Whole body water mass 0.5 2.9 6.9 0.5 -0.3 2.6 1.2 2.4
Leg predicted mass (right) 0.1 0.7 1.5 -0.7 0.4 1.1 1.2 0.6
Arm fat mass (left) 0.6 2.3 4.3 -2.1 1.9 -1.1 0.9 -1.2
Number of self-reported non-cancer illnesses 0.8 1.4 2.9 -1.5 -0.1 -1.7 0.9 -1.0
Average weekly champagne plus white wine intake 0.4 0.5 1.2 1.1 0.7 -0.0 1.0 -0.2
Miserableness 0.5 0.8 1.2 1.0 0.9 1.1 -0.6 0.8
Guilty feelings 0.5 0.7 2.1 1.4 -0.1 0.8 -1.0 -0.2
Wears glasses or contact lenses 0.6 0.7 3.1 -0.7 0.3 0.1 1.8 0.1
Ever taken oral contraceptive pill 0.2 0.3 0.7 -0.1 -0.8 -0.4 0.3 -0.5
Hearing aid user 0.5 0.6 1.5 0.1 1.0 1.2 0.6 0.5
Mother’s age at death 1.0 1.2 2.2 1.1 -0.5 1.2 -0.9 1.5
Financial situation satisfaction 2.7 3.4 11.0 3.3 1.2 1.2 1.2 1.3
Tinnitus: Yes, now most or all of the time 2.6 3.1 6.2 -2.5 1.8 -0.8 2.3 -0.6
Commuting to job workplace: Public transport 1.5 1.8 4.4 -0.7 -1.7 1.0 -2.1 0.1
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -0.2 -1.0 0.7 0.8 -0.1
Medication: Blood pressure 3.1 5.9 13.5 -2.2 0.0 -3.7 0.6 -3.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.7 -0.7 -1.3 0.3 -0.4 -0.4
Supplements: Fish oil (including cod liver oil) 1.3 1.8 4.2 1.0 -2.0 1.0 -0.8 1.4
High cholesterol (Self-reported) 0.8 1.4 4.5 -1.4 -0.1 -0.6 2.1 0.2
Medication: Bendroflumethiazide 2.7 4.1 7.6 -2.8 0.6 -2.5 1.9 -1.6
Medication: Paracetamol 0.5 0.7 1.8 -1.0 1.3 0.1 0.8 0.5
Medication: Lisinopril 0.8 1.1 2.7 0.5 0.9 -0.8 -1.6 -0.9
Medication: Atorvastatin 0.7 0.8 1.3 0.9 -0.9 0.9 0.6 1.1
Illnesses of father: High blood pressure 1.3 1.6 3.7 1.9 -1.4 1.1 0.9 0.2
Alcohol drinker status: Never 2.1 2.5 7.8 0.4 -2.8 1.5 -1.3 0.8
Ever smoked 1.0 1.7 3.0 -1.7 -1.7 1.0 1.1 0.6
Basal metabolic rate 0.4 2.0 4.8 0.2 0.0 2.2 1.1 1.9
Leg fat percentage (left) 0.9 3.4 4.7 -2.1 2.2 -1.7 1.4 -1.7
Arm fat-free mass (left) 0.7 3.3 7.2 0.5 -0.3 2.6 1.5 2.7
Number of operations (self-reported) 0.2 0.2 0.6 -0.6 -0.1 -0.4 0.1 -0.8
Average weekly beer plus cider intake 0.3 0.4 1.5 0.5 -1.2 0.6 -0.1 0.2
Irritability 1.3 2.2 3.6 0.2 -1.5 1.6 1.6 1.9
Risk taking 0.6 0.9 1.6 -1.0 1.3 -0.9 0.2 -1.0
Ever had prostate specific antigen (PSA) test 6.0 6.9 12.7 2.2 -2.1 3.6 1.0 3.4
Fractured/broken bones in last 5 years 0.3 0.4 0.9 -0.9 0.2 -0.2 0.7 1.0
Age started oral contraceptive pill 0.4 0.6 1.5 0.7 -1.2 -0.7 -0.3 -0.5
Diastolic blood pressure, automated reading 0.2 0.7 2.2 -0.2 0.5 0.4 1.5 0.9
Ever depressed for a whole week 0.7 0.9 2.9 0.2 -0.3 0.9 0.7 1.7
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.1 0.9 -0.8 0.0 -0.8
Commuting to job workplace: Cycle 1.2 1.4 3.5 -0.0 -1.1 1.9 0.4 1.5
Myopia 1.3 1.9 6.9 1.3 -2.6 -0.2 -0.5 -0.7
Vascular/heart problems diagnosed by doctor 1.0 2.8 8.2 1.6 -0.2 1.6 -2.9 0.9
Cholesterol lowering medication 0.4 0.6 1.3 -0.6 -0.4 -1.1 0.5 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 -1.2 -0.1 0.2 1.1 0.1
Pain experienced in last month 0.9 1.4 3.0 0.7 -0.3 -1.7 1.1 -1.6
Supplements: Calcium 0.4 0.4 1.0 -0.1 0.9 0.1 -1.0 -0.5
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 -1.1 0.5 -0.3 -0.7 -0.1
Heart attack/myocardial infarction (self-reported) 1.1 1.4 4.2 -0.4 -0.4 0.9 2.0 1.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.0 0.1 0.8 -0.9 -0.5 -1.7
Heart disease (siblings) 0.3 0.4 1.1 -1.0 0.5 -0.1 -0.5 0.4
Alcohol drinker status: Previous 0.6 0.6 1.8 -0.5 1.3 -0.1 0.8 0.7
Pack years of smoking 0.9 1.4 2.7 -1.2 0.1 -1.6 -0.7 -1.5
Impedance of whole body 0.1 0.5 2.1 1.4 -0.1 -0.4 -0.6 0.0
Leg fat mass (left) 0.5 1.8 3.6 -1.5 1.9 -0.9 1.2 -1.1
Arm predicted mass (left) 0.7 3.4 7.2 0.8 -0.3 2.7 1.4 2.7