Hub : Genes

USP10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.151	0.0380	9.8e-06	0.054	0.024	0.047	0.027	0.046	3.2e-07	5.7e-04	1.7e-06	2.4e-04	2.5e-06
2	GTEx	Artery Tibial	0.184	0.0565	1.0e-03	0.000	NA	-0.003	NA	-0.001	3.2e-01	NA	7.2e-01	NA	3.7e-01
3	GTEx	Colon Transverse	0.358	0.0960	6.8e-04	0.032	NA	-0.005	NA	0.021	1.1e-02	NA	7.4e-01	NA	3.2e-02
4	GTEx	Esophagus Mucosa	0.284	0.0720	1.4e-04	0.011	NA	0.026	NA	0.014	5.6e-02	NA	7.5e-03	NA	3.7e-02
5	GTEx	Spleen	0.678	0.1680	7.7e-03	0.007	NA	0.011	NA	0.077	2.0e-01	NA	1.7e-01	NA	5.1e-03
6	GTEx	Testis	0.471	0.1050	6.5e-05	0.159	NA	0.049	NA	0.114	1.5e-07	NA	3.1e-03	NA	1.0e-05
7	YFS	Blood	0.175	0.0294	1.1e-14	0.025	0.062	0.082	0.080	0.061	1.3e-08	1.5e-19	2.3e-25	5.3e-25	2.5e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.6	-0.1	-0.2	-0.3	0.4	-1.2	-0.9	1.2
Bipolar Disorder or Schizophrenia	0.2	0.6	1.7	-0.6	0.6	-0.4	0.2	-1.3	-0.9	-0.8
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	1.2	-0.9	0.5	-0.7	-0.0	-0.6	0.5
Depression (Nagel 2018)	0.5	0.7	2.1	-1.4	-0.8	1.0	0.4	0.2	0.9	0.7
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.0	-1.8	2.5	-0.6	1.0	-1.2	1.7	-1.0
Neuroticism (Nagel 2018)	0.3	0.6	1.4	-1.0	-0.6	1.2	-1.1	-0.4	0.0	0.3
Schizophrenia (2018)	0.5	1.0	4.7	-0.6	1.1	-0.2	-0.1	-0.7	-0.5	-2.2
Schizophrenia vs Biploar Disorder	1.1	1.5	3.0	0.0	-0.9	-1.0	-1.7	1.6	0.8	-1.6
Worry (Nagel 2018)	0.7	1.5	4.8	-2.2	-0.6	0.7	-1.9	-0.1	0.6	0.9
Alzheimer’s Disease (in mother)	0.2	0.2	1.2	0.2	0.4	-0.4	0.0	0.0	1.1	0.2
Alzheimer’s Disease (in father)	0.7	0.8	3.3	-0.2	-0.1	-1.0	-0.7	1.8	0.6	0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	2.9	-0.1	0.1	-1.0	-0.9	0.5	1.7	0.4
Crohns Disease (2017)	0.9	2.0	5.1	0.8	-1.9	-0.0	-2.3	-0.8	-0.7	1.8
Irritable Bowel Disease (IBD)	0.4	1.0	3.2	0.3	-1.8	-0.7	-1.7	-0.0	-0.6	0.4
Ulcerative Colitis (UC)	0.3	0.6	1.5	0.2	-1.2	-0.8	-0.5	0.9	-0.7	-0.8
Major Depression (MDD)	0.4	0.5	1.3	0.5	-0.1	-1.0	0.0	0.8	1.1	0.2
Reaction Time	0.5	0.9	3.5	0.6	-1.9	-0.6	-0.3	1.2	0.5	0.1
Verbal and Numeric Reasoning (VNR)	0.8	1.8	6.2	0.4	1.5	0.4	1.8	-0.8	2.5	0.1
Breast Cancer	0.4	1.0	2.4	-1.3	1.6	-1.0	0.2	1.5	0.2	0.0
Ovarian Cancer	0.7	0.9	3.7	-0.1	0.2	-0.4	1.9	-1.3	-0.8	-0.5
Prostate Cancer	1.6	2.3	7.5	-1.2	1.5	0.8	1.1	-2.7	1.3	-1.0
Age at First Birth	1.0	1.5	3.2	-1.8	0.9	1.4	0.6	1.8	0.7	-0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	3.6	1.9	0.3	0.7	-0.4	0.8	-0.7	0.3
Coronary Artery Disease (CAD)	1.4	1.7	5.9	2.0	-2.4	-0.1	0.8	-0.2	0.9	0.7
Crohns Disease (2012)	0.6	0.9	3.5	1.0	-0.7	-0.4	-1.9	-0.6	-0.3	0.8
Mean Putamen Volume	0.6	0.7	3.7	-0.3	0.4	-0.4	0.2	0.1	-0.9	1.9
Fasting Glucose	0.3	0.3	1.1	0.1	0.9	0.5	1.0	-0.1	0.2	-0.3
HbA1C	0.8	0.9	3.0	-0.6	1.7	-0.1	-1.0	-0.5	-0.8	1.1
HDL Cholesterol	0.8	1.4	3.8	-0.5	0.8	0.6	-1.0	-0.5	1.8	-2.0
LDL Cholesterol	0.1	0.1	0.4	0.1	0.3	-0.1	0.6	0.2	-0.2	-0.1
Lupus	0.7	1.0	2.7	1.4	-1.3	0.6	-0.0	0.2	-0.5	-1.6
Neuroticism (2016)	0.5	0.8	4.2	0.3	-0.4	0.0	-2.0	0.4	0.6	0.7
Primary Biliary Cirrhosis	2.4	3.4	9.3	-3.0	1.0	-2.5	-1.1	1.1	2.1	0.4
Rheumatoid Arthritis	0.4	0.6	1.6	-0.8	-0.9	-1.3	0.8	-0.6	-0.2	0.1
Schizophrenia (2014)	0.5	1.2	4.0	-0.6	0.4	-1.1	-0.4	-0.1	-2.0	-1.6
Triglycerides	0.7	1.2	4.4	0.8	-0.3	-2.1	-0.3	0.0	-1.1	1.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.5	0.1	1.2	-0.3	-1.6	0.0	-0.2	-0.2
Ulcerative Colitis	1.2	1.8	5.4	-1.1	1.0	-2.3	-0.6	0.8	1.4	-1.3
Blood Eosinophil Count	0.1	0.5	1.3	-0.5	0.5	-0.5	-0.9	-1.1	-0.8	-0.0
Blood Platelet Count	0.2	2.8	7.8	2.8	-1.7	-1.8	1.4	0.2	-1.9	0.3
Blood Red Count	0.1	1.0	3.1	1.0	-1.8	-1.1	-0.7	-0.9	-0.5	0.5
Blood White Count	0.3	2.1	4.8	1.3	-1.5	-1.5	-0.8	0.5	-2.2	1.6
Heel T-Score	0.1	1.1	3.4	1.8	-1.0	0.3	0.9	1.0	-1.1	0.5
BMI	0.3	1.8	3.5	1.5	-1.9	-0.7	1.4	-0.5	-1.9	0.8
Height	1.4	27.2	92.9	-6.6	5.3	2.5	0.1	1.3	9.6	-4.2
Waist Hip Ratio (WHR)	0.8	3.7	7.7	-2.1	2.5	-0.1	1.2	2.0	2.8	-1.5
Systolic Blood Pressure	0.2	1.2	5.8	0.2	-0.1	-0.7	-1.3	0.2	0.3	-2.4
Smoking Status	0.3	0.8	1.7	0.0	0.8	-0.8	-1.2	-0.0	-1.3	-0.9
Allergy or Eczema	0.2	0.5	1.5	-0.6	0.2	-0.0	0.5	-1.1	-0.1	-1.2
Cardiovascular Disease	0.1	0.4	1.3	-0.1	-0.2	-0.8	-1.1	-0.6	-0.7	-0.6
Hypothyroidism (self reported)	0.2	0.6	1.4	-0.4	0.2	-1.2	-0.6	0.6	-1.2	0.2
Respiratory disease	0.5	1.2	4.6	-0.0	-2.1	-1.0	-0.5	-0.7	-0.7	-1.1
Type 2 Diabetes (T2D) (2018)	2.4	4.5	15.1	-0.6	1.9	1.3	1.9	-2.3	1.3	-3.9
Lung FEV1/FVC ratio	0.4	1.9	3.5	1.1	-1.9	-1.8	-1.1	0.3	-1.6	1.3
Lung FVC	0.2	1.1	4.0	0.2	1.1	-0.2	-2.0	0.4	-1.0	1.1
Neuroticism	0.6	1.5	4.1	-0.7	-0.7	1.8	-2.0	-1.2	-1.0	0.1
Chronotype (morning person)	0.4	1.0	3.3	1.8	-1.2	0.9	-0.1	0.9	0.2	-0.6
Hair Pigment	0.0	0.6	1.8	0.6	-1.4	0.6	-0.6	1.0	-0.6	-0.3
Tanning	0.1	0.8	2.3	-1.2	1.5	1.2	0.1	-0.1	-0.4	0.0
Hand grip strength (left)	0.3	0.8	2.8	0.8	0.7	-0.3	-1.1	-0.2	1.7	0.8
Number of treatments/medications taken	0.7	1.2	2.9	0.9	-1.7	-1.3	-0.6	-0.7	-1.3	-0.6
Average weekly spirits intake	0.2	0.2	0.4	-0.5	-0.2	0.3	-0.6	-0.6	-0.6	0.4
Sensitivity / hurt feelings	0.9	1.5	2.5	-1.2	-1.5	0.8	-1.6	1.0	-1.0	1.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.1	-0.9	-1.0	0.8	1.0	1.8	-0.2	0.9
Hearing difficulty/problems: Yes	0.8	1.3	5.9	1.1	0.5	0.0	0.8	-0.2	0.9	-2.4
Relative age of first facial hair	0.2	0.5	0.7	-0.8	0.8	0.7	0.8	0.4	0.5	-0.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	5.0	-0.7	-1.6	-2.2	-0.8	0.5	-0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	0.5	-1.3	-1.5	-0.1	0.7	-1.4	-0.4
Ever had hysterectomy (womb removed)	1.2	1.4	3.9	2.0	-1.1	-0.2	-0.4	0.8	0.6	-1.8
Systolic blood pressure, automated reading	0.4	1.0	3.2	1.5	-0.3	-0.8	0.5	0.5	-0.8	-1.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.1	-0.5	1.4	-1.0	-0.6	-0.3	-0.1	-0.0
Angina	0.1	0.1	0.3	-0.0	0.6	0.5	-0.3	0.3	-0.2	0.4
Medication for hormone replacement therapy	2.6	2.9	9.9	3.2	-2.5	-0.6	-1.2	-0.5	-0.8	1.3
Vitamin and mineral supplements	1.0	1.4	4.6	1.4	-0.9	0.7	2.1	0.2	1.3	-0.7
Supplements: Zinc	1.3	1.4	3.3	-1.0	-0.5	-0.6	-1.8	-0.9	0.9	-1.8
Medication: Co-codamol	1.7	1.9	7.9	-0.1	-1.0	-2.8	-1.5	0.2	1.0	1.1
Medication: Metformin	1.3	1.8	7.0	-0.5	0.8	0.5	2.6	-1.3	-0.3	-1.6
Diabetes (father)	2.2	2.8	6.6	1.8	-1.2	-1.5	-2.0	-2.6	0.9	-1.0
Diabetes (mother)	0.5	0.6	1.3	-0.3	0.7	-0.8	1.0	1.1	0.2	-0.9
Severe depression (siblings)	0.6	0.7	1.7	-0.1	1.3	-1.1	0.4	0.1	1.1	0.3
Pack years adult smoking proportion	1.3	2.0	4.8	2.2	-1.7	-0.9	0.4	0.8	-2.1	0.2
Impedance of leg (right)	1.5	7.0	16.8	-4.1	3.9	1.1	-0.8	0.8	3.1	-2.2
Leg fat-free mass (left)	0.0	0.3	0.9	0.7	-1.0	0.3	-0.2	0.1	-0.5	0.2
Trunk fat percentage	0.5	1.9	8.6	-1.4	1.0	-0.4	1.0	0.2	-0.6	-2.9
Hand grip strength (right)	0.4	1.0	5.3	-0.5	1.0	-0.2	-0.1	-0.5	2.3	0.6
Townsend deprivation index at recruitment	1.5	2.1	6.0	2.4	0.2	-1.7	-1.2	-1.3	-1.4	0.6
Current tobacco smoking	0.6	1.0	2.5	1.1	0.2	-1.6	-0.4	1.1	-0.2	-1.4
Average weekly fortified wine intake	0.7	0.9	2.6	0.8	0.0	-0.4	1.4	-0.3	1.6	-0.9
Maternal smoking around birth	1.0	1.5	5.2	2.3	-1.3	0.5	0.4	1.2	-0.7	1.1
Fed-up feelings	0.6	1.2	5.1	-0.3	-0.3	-1.1	-0.1	0.2	-2.3	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.1	-1.0	-0.9	-0.4	1.4	0.7	-0.1	0.8
Relative age voice broke	0.2	0.3	0.8	-0.2	0.7	0.3	0.9	0.6	0.0	-0.2
Taking other prescription medications	0.8	1.3	3.6	-0.3	-0.4	-1.9	1.1	-1.5	-0.9	-0.8
Age when periods started (menarche)	0.5	1.3	3.9	2.0	-1.8	0.6	-0.4	-0.8	-0.7	0.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.7	1.5	-1.9	-1.0	1.1	0.8	-1.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.3	-0.9	-0.4	1.1	-0.7	-0.1	-0.4	-1.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.0	-0.6	0.8	-1.5	1.6	-0.0	-0.2	-1.7
Qualifications: CSEs or equivalent	1.1	1.5	2.8	1.6	-0.6	-0.6	1.7	-0.0	-1.6	1.5
Serious illness, injury or assault to yourself	0.5	0.7	1.5	1.2	-0.5	-0.8	0.7	-0.8	-0.9	-0.4
High blood pressure	0.4	1.2	3.5	0.3	-1.1	-1.7	-0.6	0.4	-1.9	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	0.6	-0.7	0.0	-1.3	0.3	-0.6	0.4
Multivitamins +/- minerals	0.2	0.3	0.7	-0.4	0.8	-0.1	-0.6	0.3	0.3	0.7
Stomach or abdominal pain in last month	1.1	1.4	5.1	-0.9	-0.8	-1.6	0.6	-0.4	-0.7	-2.3
Supplements: Glucosamine	0.7	0.9	1.9	-1.4	0.9	1.3	-1.1	0.5	0.4	0.4
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.5	-0.7	-0.1	1.4	1.4	-1.0	0.9	-1.9
Medication: Atenolol	0.8	1.1	3.0	-1.7	0.3	-1.1	1.5	0.6	0.1	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.6	0.2	-0.5	-1.2	0.8	0.6	0.8
Sitting height	0.3	2.0	4.4	-1.4	-0.2	1.5	-1.5	0.4	2.1	-1.8
Chronic bronchitis/emphysema (father)	0.4	0.5	2.5	0.5	-0.4	0.2	0.7	-1.6	-0.4	-0.4
High blood pressure (mother)	0.6	0.8	1.6	-0.7	-0.7	-1.2	-0.6	0.8	-0.7	1.3
Body mass index (BMI)	0.9	3.6	12.2	2.1	-2.1	-1.2	1.8	-0.3	-3.5	0.1
Impedance of leg (left)	1.3	6.1	12.5	-3.5	3.2	0.8	-1.2	0.8	3.2	-2.5
Leg predicted mass (left)	0.1	0.3	1.0	0.7	-1.0	0.3	-0.2	0.1	-0.5	0.2
Trunk fat mass	0.3	1.1	5.3	-1.1	0.7	-0.2	0.9	0.3	-0.4	-2.3
Waist circumference	0.2	0.6	2.5	-0.5	-0.1	-0.7	1.6	0.6	-0.4	-0.7
Number of incorrect matches in round	1.1	1.8	5.4	-1.7	0.8	1.8	0.8	-0.0	0.5	-2.3
Past tobacco smoking	1.0	1.9	5.4	1.1	-1.6	0.3	2.3	1.1	1.5	0.5
Alcohol usually taken with meals	1.0	1.6	6.4	-1.0	1.9	-0.1	2.5	0.7	-0.3	-0.2
Nervous feelings	0.5	0.9	3.5	-1.9	-1.0	-0.3	-0.8	0.8	0.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.5	-1.9	-0.9	-0.1	-1.3	1.9	-1.1	1.5
Hearing difficulty/problems with background noise	0.2	0.3	1.0	0.8	0.1	-0.1	0.4	0.7	1.0	-0.2
Hair/balding pattern: Pattern 2	2.0	2.6	4.2	1.5	-2.1	-1.1	-1.7	-1.2	-1.6	1.9
Had menopause	0.5	0.6	2.3	0.2	-0.7	0.4	-0.5	-1.5	0.6	-0.7
Had other major operations	1.0	1.2	4.1	0.7	0.2	-1.0	-1.6	0.3	-2.0	-0.2
Forced vital capacity (FVC)	0.8	3.0	6.4	-0.6	1.6	1.0	-2.5	1.9	2.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	7.7	-1.5	0.7	1.8	-0.6	0.1	-0.1	-2.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.4	1.1	0.2	-0.7	1.0	0.1	0.7
Qualifications: None of the above	0.2	0.5	1.5	0.5	-1.0	0.2	-1.2	0.3	-0.5	-0.2
Financial difficulties in last 2 years	0.4	0.5	1.4	0.5	-0.6	0.3	0.6	0.8	-1.2	-0.5
Mouth/teeth dental problems	1.0	1.6	5.0	-2.2	1.7	0.5	1.0	0.0	1.3	0.1
Heart attack	1.7	2.1	6.7	-1.6	1.3	-0.3	0.2	-1.8	0.8	-2.6
Allergy	0.4	0.8	2.9	-0.8	1.7	-0.4	0.6	-0.4	1.2	0.3
Pain all over the body in last month	1.8	1.9	7.2	0.9	-2.7	0.0	0.2	-0.3	-2.0	1.0
Diabetes (self-reported)	1.7	2.7	11.0	0.7	0.2	0.1	2.4	-1.1	-0.1	-3.3
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	8.8	-3.0	1.4	1.9	-0.8	0.0	-0.5	-1.7
Medication: Ramipril	1.3	1.6	5.8	-2.4	0.4	-1.6	-1.1	-0.6	-0.7	1.0
Medication: Simvastatin	0.8	1.1	2.6	-0.7	-0.6	-1.1	-1.2	-1.4	-1.6	-0.2
Fluid intelligence score	0.5	1.1	2.8	-0.2	0.6	1.0	1.7	-0.9	1.4	-0.8
Illnesses of siblings	0.6	0.9	2.9	0.4	0.7	1.2	0.9	1.7	0.5	0.0
Neuroticism score	0.4	0.8	1.2	-1.1	-0.9	1.1	-1.0	0.1	-1.0	0.8
Weight	0.1	0.3	1.1	-0.0	-0.7	-0.2	0.6	0.3	-0.2	-1.1
Impedance of arm (right)	1.6	7.6	27.1	-5.2	2.5	1.3	-0.4	0.9	2.9	-2.9
Arm fat percentage (right)	0.5	2.1	5.4	-0.3	-0.5	-0.5	2.3	-0.1	-2.3	-2.0
Trunk fat-free mass	0.1	0.6	2.2	0.2	-0.5	0.3	-1.5	0.3	1.1	0.5
Hip circumference	0.1	0.5	1.7	-0.7	-0.8	-0.5	0.3	0.2	-1.3	-0.7
Time employed in main current job	1.1	1.3	2.6	-1.6	0.9	1.3	0.3	-1.4	0.6	-1.2
Alcohol intake versus 10 years previously	0.5	0.7	2.0	1.1	-0.4	0.6	-0.4	0.4	-1.1	-1.4
Father’s age at death	2.3	3.1	12.5	0.1	2.2	1.1	1.1	-0.4	3.5	-1.2
Worrier / anxious feelings	0.7	1.4	5.4	-2.3	0.6	0.4	-1.8	-0.2	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	9.2	-0.8	-1.6	0.0	-1.6	0.5	-3.0	0.6
Falls in the last year	1.1	1.5	4.1	0.7	-1.1	-0.2	1.7	-0.6	-2.0	-1.2
Hair/balding pattern: Pattern 3	0.5	0.7	3.0	-0.9	-0.1	0.2	0.0	1.7	-0.7	0.8
Number of live births	1.1	1.6	7.3	1.5	-0.8	0.1	0.9	2.7	-0.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.0	0.0	1.2	0.5	-2.5	1.9	1.5	0.8
Pulse rate	0.6	0.9	2.4	-0.3	0.1	-1.6	1.2	1.5	-0.2	-0.6
Happiness	0.5	0.6	2.5	0.2	0.8	-1.1	1.6	0.0	0.3	0.2
Noisy workplace	0.8	0.9	4.1	-0.4	1.0	0.0	1.1	-0.3	0.5	-2.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.7	-0.2	1.4	0.2	0.1	-1.2	1.6	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.0	1.7	0.4	0.4	0.9	0.2	0.4	-0.6
Mouth/teeth dental problems: Dentures	1.3	2.1	3.8	1.6	-1.4	-0.3	0.2	-2.0	-1.6	-1.9
Asthma	0.3	0.6	1.5	-0.2	-1.0	-1.2	-0.7	-0.6	-0.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.4	0.9	1.8	-0.5	0.6	0.6	-0.1	-0.1
Medication: Cholesterol lowering	0.5	0.8	2.8	0.1	0.1	0.5	0.5	-1.7	-1.4	-0.4
Depression (self-reported)	1.2	1.4	4.0	-0.2	-0.2	-0.7	2.0	-2.0	-1.1	-0.4
Medication: Lansoprazole	1.3	1.5	6.8	0.4	-2.6	0.4	-0.6	-1.0	-1.1	-0.8
Prospective memory result	1.2	1.5	4.1	1.2	-0.7	-0.1	-1.5	2.0	-1.2	0.8
Lung cancer (father)	0.5	0.6	1.5	1.2	0.2	0.4	-1.0	0.2	0.8	-0.7
Illnesses of mother	0.7	0.8	1.9	-0.1	-0.8	0.7	0.1	-1.3	-1.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.5	-0.1	1.1	0.9	-2.7	1.9	1.6	0.7
Pulse wave Arterial Stiffness index	1.2	1.5	4.1	0.8	-0.9	-2.0	-1.0	0.5	0.7	-1.7
Impedance of arm (left)	1.1	5.2	13.2	-3.6	2.6	1.0	-0.0	0.9	3.2	-2.2
Arm fat mass (right)	0.3	1.4	4.8	0.5	-0.8	-0.6	1.5	-0.0	-2.2	-1.2
Trunk predicted mass	0.1	0.6	2.5	0.4	-0.5	0.3	-1.6	0.3	1.1	0.5
Standing height	1.3	13.4	44.6	-4.4	3.1	2.0	-2.9	1.4	6.7	-2.4
Length of working week for main job	0.5	0.5	0.9	-0.2	-0.6	-0.4	-1.0	0.9	0.7	-1.0
Exposure to tobacco smoke at home	0.9	1.0	1.8	0.3	-1.3	1.4	-1.0	0.9	-1.0	0.7
Breastfed as a baby	1.5	1.8	4.0	-2.0	1.4	1.2	0.2	-1.7	1.5	-0.2
Tense / ‘highly strung’	1.6	2.7	7.7	-1.2	-0.9	-0.8	-1.4	0.9	-2.3	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	6.2	-2.3	1.5	-0.1	0.7	-0.2	0.9	-2.5
Hair/balding pattern: Pattern 4	0.9	2.1	5.6	1.1	1.9	-0.4	1.9	-0.4	0.7	-2.4
Birth weight of first child	1.0	1.8	6.4	-2.1	1.1	0.2	-2.5	0.4	0.6	-0.1
Peak expiratory flow (PEF)	0.4	0.9	3.5	1.1	0.0	0.0	-1.9	0.7	0.2	1.1
Pulse wave reflection index	1.5	1.9	3.9	2.0	-1.6	-1.8	-1.7	0.5	-0.7	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.1	-0.7	-0.8	0.3	0.6	-0.4	0.3
Loud music exposure frequency	0.2	0.2	0.8	0.2	-0.4	0.4	-0.5	-0.4	-0.9	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.8	-1.3	0.7	1.3	-1.2	-0.7	1.0	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.8	0.5	-1.1	0.1	-1.3	1.1	-0.6	0.4
Blood clot in the leg (DVT)	0.8	1.0	2.5	0.1	-1.6	1.3	0.6	0.0	-0.1	-1.5
Medication: Paracetamol	1.4	2.3	5.4	1.7	-1.3	-0.3	-2.1	1.2	-2.3	0.5
Headache pain in last month	0.4	0.7	2.9	0.6	1.7	0.3	0.9	-0.9	0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	0.0	-0.2	-1.2	-0.3	0.9	1.3	0.0
Glaucoma (self-reported)	1.0	1.1	3.7	1.9	-1.1	1.1	1.0	0.5	0.5	-0.3
Gout (self-reported)	1.8	2.5	8.9	-0.6	2.0	-1.0	1.0	0.4	1.5	-3.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.7	-0.1	0.2	-1.3	-1.2	0.2	-1.2	1.2
Medication: Amlodipine	0.3	0.4	0.7	0.1	-0.7	-0.7	-0.5	0.3	-0.9	0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	-0.6	-1.1	-0.9	-0.7	-0.7	0.7	1.4
Birth weight	0.8	1.6	6.1	-0.7	0.4	-0.7	-1.7	0.6	0.8	-2.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.6	0.7	0.5	-1.2	-1.0	1.9	0.2	-1.5
High blood pressure (siblings)	0.6	0.9	1.9	0.2	-0.7	-1.2	-1.1	-1.4	-1.0	0.3
Forced vital capacity (FVC), Best measure	1.0	3.8	7.4	-1.0	1.9	1.9	-2.7	1.9	2.7	0.3
Body fat percentage	0.4	1.6	6.1	-1.1	0.6	-0.4	1.5	0.1	-1.1	-2.5
Leg fat percentage (right)	0.3	1.2	3.6	-0.2	0.1	-0.5	1.9	0.1	-1.6	-1.4
Arm fat-free mass (right)	0.1	0.5	1.3	1.1	-0.3	-0.1	-1.1	0.3	0.7	0.5
Exposure to tobacco smoke outside home	0.4	0.6	1.4	1.2	0.2	0.6	1.0	1.0	0.5	-0.4
Comparative body size at age 10	0.2	0.6	1.3	-1.1	1.0	-0.5	0.3	-0.3	-1.1	0.1
Number of full brothers	1.0	1.2	3.3	1.8	-1.6	-0.7	-0.3	-0.2	1.0	-0.9
Worry too long after embarrassment	0.8	1.3	3.0	-1.7	1.1	1.7	-0.4	-0.9	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.1	-1.8	0.4	-0.7	0.7	-0.5	-0.0	-1.3
Wheeze or whistling in the chest in last year	0.5	1.0	2.5	-0.2	-1.6	0.2	-1.1	0.8	-1.5	-0.3
Number of children fathered	0.6	0.6	1.8	1.0	-1.3	0.7	0.5	-0.7	0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.0	0.8	-0.7	1.7	-1.1	-1.7	0.1	0.9
Age at first live birth	1.2	2.1	6.4	-2.5	1.2	1.2	-1.3	-0.1	-0.7	1.9
Pulse wave peak to peak time	1.4	1.6	4.9	-1.2	1.4	2.2	1.0	-0.5	-0.2	1.4
Health satisfaction	0.6	0.8	2.1	-0.9	-0.7	-1.5	-0.3	0.2	-1.0	1.0
Shortness of breath walking on level ground	0.8	0.9	3.6	-0.7	-0.1	-0.2	-1.9	0.4	-0.9	1.2
Qualifications: College or University degree	0.1	0.4	1.3	0.3	0.5	-0.1	-0.1	0.4	1.1	1.0
Eye problems/disorders: None of the above	0.9	1.0	4.5	-2.1	0.8	-0.5	-1.1	0.7	0.2	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.5	-0.0	0.8	-0.4	-0.7	1.9	-0.0	-0.8
Emphysema/chronic bronchitis	1.2	1.4	4.9	-0.3	0.3	0.6	1.5	1.1	0.8	-2.2
Medication for pain relief, constipation, heartburn	0.9	1.6	3.2	-1.2	1.3	0.9	1.6	1.1	1.8	0.4
Neck or shoulder pain in last month	0.8	1.1	4.0	-0.3	0.1	1.1	0.8	1.3	0.3	-2.0
Medication: Blood pressure	0.4	0.7	2.7	-0.7	-0.5	1.0	0.3	0.3	-1.6	-0.1
Angina (self-reported)	0.2	0.2	1.2	0.2	0.4	1.1	-0.0	0.3	-0.0	0.4
Migraine (self-reported)	1.2	1.5	3.3	0.4	-1.1	0.8	-1.8	0.0	-1.8	1.3
Medication: Ibuprofen	0.5	0.6	1.8	0.9	0.9	0.5	0.5	1.3	0.5	0.1
Medication: Allopurinol	2.3	3.1	10.4	-0.3	1.4	-1.9	1.9	0.3	1.4	-3.2
Medication: Omeprazole	0.4	0.5	1.2	-1.1	-1.0	-0.4	0.0	-0.9	0.0	0.2
Medication: Seretide 50 evohaler	0.7	0.8	3.4	-1.8	-0.4	-0.9	-1.1	0.1	-0.2	-0.1
Mean time to correctly identify matches	0.4	0.7	2.0	-0.2	-0.4	-0.9	0.0	1.4	1.1	-1.0
Heart disease (mother)	0.1	0.2	0.6	0.0	-0.8	-0.4	0.2	-0.0	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.9	0.4	0.8	-0.5	0.6	-1.0	0.3
Whole body fat mass	0.2	1.0	3.5	-0.4	0.2	-0.0	1.3	0.2	-1.2	-1.9
Leg fat mass (right)	0.3	1.1	3.4	0.3	-0.0	-0.2	1.8	-0.1	-1.6	-1.2
Arm predicted mass (right)	0.1	0.6	2.1	1.4	-0.1	-0.1	-1.3	0.1	0.7	0.5
Pulse rate, automated reading	0.3	0.8	2.6	1.2	0.3	-1.2	-0.2	0.4	-0.1	-1.6
Alcohol intake frequency.	0.5	1.2	2.3	-0.9	-1.5	-1.1	-0.0	1.0	-1.4	1.0
Comparative height size at age 10	2.4	13.1	33.1	-5.3	4.5	0.8	-1.4	-0.0	5.8	-2.9
Number of full sisters	1.0	1.2	4.6	-1.0	0.0	2.2	0.4	0.9	-1.1	0.7
Suffer from ‘nerves’	0.7	1.1	2.9	-1.5	0.2	1.7	0.3	1.3	0.9	-0.1
Overall health rating	0.4	0.8	3.6	0.2	-0.8	-0.8	0.7	-0.3	-1.9	0.0
Chest pain or discomfort	0.9	1.3	6.5	0.7	-0.9	0.4	0.0	-0.4	-2.5	-0.9
Had major operations	1.5	1.7	6.8	-0.1	-1.4	-2.6	-1.6	-0.3	0.7	0.2
Age at last live birth	1.1	1.6	4.4	-1.0	-0.4	1.0	-0.6	0.2	-2.0	2.1
Family relationship satisfaction	0.2	0.2	1.0	-0.2	0.6	-0.1	1.0	-0.1	0.4	-0.1
Leg pain on walking	0.8	1.0	3.3	1.1	-1.8	-0.8	0.2	0.5	-0.5	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.5	0.3	1.0	-0.3	2.1	1.4	0.2	-1.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	-0.2	1.0	0.1	-1.1	0.7	0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.2	-0.6	-0.2	-0.5	-0.4	0.5	1.1	0.4
Medication: Aspirin	1.1	1.5	5.1	-0.5	-1.1	-0.8	-0.7	-2.3	-0.6	-1.5
Supplements: Vitamin C	2.7	3.2	16.0	-1.8	0.0	-0.7	-4.0	-1.4	-0.6	-0.7
Knee pain experienced in last month	1.0	1.6	5.2	1.2	-0.9	0.2	1.4	2.3	-1.3	0.4
Hypertension (Self-reported)	0.5	1.3	3.5	0.4	-1.4	-1.4	-0.8	0.7	-1.9	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.1	-0.7	0.2	1.5	0.6	-0.3	-0.5	-0.6
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.0	0.5	0.2	0.9	0.1	0.9	-0.5
Illnesses of siblings: Diabetes	0.8	1.0	4.3	0.6	-0.2	-0.9	-2.1	-1.2	-0.2	0.2
Smoking status: Previous	1.4	2.1	5.2	-1.3	1.7	-0.3	-2.3	-1.5	-1.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	12.2	-1.2	1.8	1.1	-3.5	2.2	1.6	0.1
Whole body fat-free mass	0.1	0.4	1.3	0.6	-0.7	0.1	-1.1	0.2	0.5	0.5
Leg fat-free mass (right)	0.1	0.5	1.8	1.2	-1.3	-0.1	-0.5	0.1	-0.2	0.2
Arm fat percentage (left)	0.5	2.1	6.0	0.4	-0.6	-0.7	2.4	0.1	-2.4	-1.4
Average weekly red wine intake	0.5	0.7	1.3	1.2	0.8	0.2	0.9	1.0	1.0	0.6
Handedness (chirality/laterality): Left-handed	1.0	1.3	3.7	-1.9	1.9	-0.4	-0.7	-0.5	-0.1	0.7
Mood swings	0.2	0.4	1.2	0.4	0.8	0.3	-0.4	0.8	0.1	-1.1
Loneliness, isolation	2.2	3.0	12.2	1.7	-2.2	-0.6	-0.3	0.4	-3.5	0.5
Long-standing illness, disability or infirmity	0.9	1.4	3.5	0.6	-1.5	-1.9	0.7	0.0	-1.3	-1.2
Ever had bowel cancer screening	0.9	1.0	2.4	-1.2	1.6	-0.7	0.1	0.5	-0.5	-1.5
Diabetes diagnosed by doctor	2.3	3.8	17.4	0.1	1.1	0.5	2.1	-1.6	0.5	-4.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.8	-0.3	0.0	0.8	-0.2	-1.4	0.6	0.8
Friendships satisfaction	0.6	0.7	2.3	-0.7	0.5	0.5	-1.1	0.4	-0.5	1.5
Qualifications: nursing, teaching	1.5	2.3	9.1	-3.0	1.2	-0.6	0.7	-2.0	0.9	-0.2
Commuting to job workplace: Walk	0.6	0.6	2.2	0.1	-0.5	0.5	1.5	-0.1	1.3	-0.2
Eye problems/disorders: Cataract	0.4	0.5	1.8	0.7	0.1	0.3	-1.4	0.2	0.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.1	0.2	-0.1	-0.3	-0.3	0.7	0.6
Medication for cholesterol	1.1	1.7	5.0	-1.1	1.9	2.2	1.3	0.4	-0.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.9	-2.1	0.1	0.3	0.6	0.4	0.3	-2.2
Back pain experienced in last month	0.9	1.3	3.1	-0.9	-0.5	-1.3	-1.4	0.9	-1.8	-0.8
Mineral and other dietary supplements	0.3	0.5	1.3	1.1	-0.9	-0.3	0.1	0.2	0.1	0.9
Breast cancer (self-reported)	0.7	0.8	2.7	-0.5	1.0	-0.7	-0.4	1.2	-1.6	-0.0
Asthma (self-reported)	0.3	0.5	1.3	0.1	-1.1	-1.1	-0.4	-0.4	-0.3	-0.9
Osteoporosis (self-reported)	0.8	1.0	3.2	-0.5	-0.3	0.1	1.8	-1.7	-0.2	-0.7
Osteoarthritis (self-reported)	0.9	1.2	6.2	0.3	-0.9	-2.5	-0.6	0.7	-0.4	0.4
Medication: Aspirin	1.3	1.7	7.3	-0.6	-0.7	-0.8	-0.9	-2.7	-0.5	-1.3
Medication: Gliclazide	1.1	1.2	2.9	0.3	0.2	1.5	0.6	-1.2	1.2	-1.7
Illnesses of father: None of the above (group 1)	1.5	1.9	4.4	1.9	-0.7	1.2	0.7	1.0	-2.1	1.4
Smoking status: Current	0.7	1.1	4.1	1.1	0.3	-0.9	-0.0	1.1	0.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	1.1	0.7	1.0	-1.6	1.1	-0.8	0.3
Whole body water mass	0.1	0.4	1.6	0.6	-0.8	0.0	-1.3	0.1	0.4	0.5
Leg predicted mass (right)	0.1	0.5	1.8	1.2	-1.4	-0.0	-0.4	0.1	-0.2	0.2
Arm fat mass (left)	0.3	1.2	3.8	0.7	-0.7	-0.8	1.2	0.1	-2.0	-1.1
Number of self-reported non-cancer illnesses	1.8	3.1	5.6	-0.4	-1.6	-2.1	0.2	-2.4	-2.0	-2.2
Average weekly champagne plus white wine intake	1.1	1.5	4.4	-0.6	1.7	1.5	0.4	2.1	0.1	-0.9
Miserableness	0.4	0.7	1.9	0.7	-0.0	0.8	-0.3	1.1	0.5	1.4
Guilty feelings	0.9	1.4	8.9	0.0	-0.8	3.0	0.1	-0.6	0.2	-0.1
Wears glasses or contact lenses	0.6	0.7	2.0	0.6	0.1	0.4	-0.5	-1.2	0.9	-1.4
Ever taken oral contraceptive pill	1.1	1.3	4.6	1.5	-0.6	0.9	0.0	0.7	-0.5	2.1
Hearing aid user	0.4	0.5	1.5	-0.8	0.8	0.0	-0.4	1.2	0.6	-0.2
Mother’s age at death	1.3	1.6	4.4	-1.5	2.1	-0.7	0.9	1.0	0.6	-1.3
Financial situation satisfaction	1.5	1.8	3.7	1.1	-1.9	0.7	-0.2	0.5	-1.9	1.9
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	0.1	-0.4	1.0	0.0	0.2	0.7	-0.9
Commuting to job workplace: Public transport	0.3	0.4	1.2	-1.1	-0.0	-0.9	-0.4	-0.4	-0.5	-0.0
Eye problems/disorders: Glaucoma	1.3	1.5	5.4	1.2	-0.2	1.4	2.3	0.8	0.1	-1.1
Medication: Blood pressure	0.8	1.4	6.8	-0.8	-1.1	-2.6	-0.8	-0.6	-0.6	-0.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.7	0.6	-0.3	0.5	0.9	0.4	-1.0	-1.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.0	-1.1	1.0	0.0	0.0	-0.4	1.1	-1.7
High cholesterol (Self-reported)	1.7	3.1	8.5	0.7	-0.4	-0.7	-2.9	-2.6	-2.2	-0.1
Medication: Bendroflumethiazide	0.3	0.5	1.7	-0.6	-0.2	-0.0	-0.1	-1.3	-1.2	-0.0
Medication: Paracetamol	1.6	2.4	3.6	1.7	-1.9	0.5	-1.8	1.8	-1.8	0.6
Medication: Lisinopril	0.9	1.2	4.0	0.5	-2.0	0.5	1.5	-0.6	-1.0	0.3
Medication: Atorvastatin	0.7	0.8	3.2	1.8	-0.5	0.3	0.3	-0.4	0.4	-1.4
Illnesses of father: High blood pressure	0.6	0.7	2.4	-0.8	0.5	0.1	-1.6	0.8	0.6	-0.8
Alcohol drinker status: Never	1.9	2.3	6.0	1.8	-2.5	0.1	-1.1	1.3	0.3	2.0
Ever smoked	0.8	1.4	3.2	-1.1	1.0	-0.9	-1.6	-0.7	-1.8	-0.8
Basal metabolic rate	0.0	0.2	0.6	0.5	-0.7	0.0	-0.8	0.4	0.2	0.1
Leg fat percentage (left)	0.3	1.2	2.7	0.3	-0.6	-0.7	1.6	0.0	-1.6	-1.5
Arm fat-free mass (left)	0.1	0.6	2.5	0.8	-0.8	-0.2	-1.6	-0.2	0.2	0.1
Number of operations (self-reported)	1.3	2.0	5.0	0.2	-1.7	-2.1	-0.0	0.2	-2.2	-1.1
Average weekly beer plus cider intake	0.6	0.9	6.0	2.5	0.2	-0.4	0.2	-0.2	0.1	-0.0
Irritability	0.1	0.2	1.0	0.1	-0.4	0.6	-0.1	-1.0	-0.1	0.3
Risk taking	3.8	5.6	16.4	2.5	-4.0	-0.1	-0.9	-1.1	-3.5	1.5
Ever had prostate specific antigen (PSA) test	2.6	3.0	8.4	0.1	0.7	0.9	2.8	-0.1	1.8	-2.9
Fractured/broken bones in last 5 years	0.8	1.0	2.4	-0.6	0.6	-0.8	1.4	1.5	-1.0	-0.5
Age started oral contraceptive pill	0.4	0.5	1.3	0.9	-0.0	-0.3	-0.0	0.3	1.2	-1.1
Diastolic blood pressure, automated reading	0.7	2.3	6.0	1.6	-2.5	-1.2	0.2	0.5	-2.4	-0.1
Ever depressed for a whole week	0.6	0.7	1.7	-0.6	0.5	-0.7	-1.3	1.1	-0.3	0.9
Unable to work because of sickness or disability	2.0	2.5	7.4	2.1	-1.6	-0.9	2.7	0.8	-1.4	0.1
Commuting to job workplace: Cycle	3.2	3.8	16.3	-1.3	0.0	-0.6	1.5	0.4	2.5	-4.0
Myopia	0.7	1.0	2.6	0.4	-0.8	-1.3	0.6	-0.8	-0.9	1.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.7	-0.0	0.8	1.9	0.5	0.1	1.5	0.8
Cholesterol lowering medication	0.7	1.1	2.6	0.3	-0.0	-1.6	-0.7	-0.7	1.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	-1.2	-1.6	-0.8	-0.2	-1.4	-0.4	0.4
Pain experienced in last month	0.6	1.1	3.5	-0.3	-0.0	-1.1	1.0	-1.4	1.9	-0.2
Supplements: Calcium	0.8	0.9	3.1	-0.7	-0.0	0.3	1.8	0.4	-1.3	1.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	1.1	-1.2	-0.2	-0.3	-0.7	-0.7	-1.1
Heart attack/myocardial infarction (self-reported)	1.2	1.6	5.6	-1.4	1.0	-0.2	0.0	-1.5	0.5	-2.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.8	0.1	-1.4	1.1	0.7	0.5	0.0	-1.2
Heart disease (siblings)	0.4	0.5	1.1	1.1	-0.8	0.6	0.1	-0.9	-0.6	-0.3
Alcohol drinker status: Previous	0.7	0.8	2.7	-0.3	0.2	-1.6	-0.0	0.8	-0.5	1.3
Pack years of smoking	0.8	1.2	3.1	1.6	-1.2	-0.8	0.4	0.5	-1.8	-0.3
Impedance of whole body	1.4	7.1	16.8	-4.1	3.3	1.1	-0.7	1.0	3.5	-2.6
Leg fat mass (left)	0.3	1.1	2.6	0.5	-0.3	-0.4	1.6	-0.3	-1.6	-1.4
Arm predicted mass (left)	0.1	0.4	1.8	0.6	-0.5	-0.6	-1.4	-0.0	0.5	-0.2