Hub : Genes

TLDC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.389	0.0850	2.1e-04	0.156	NA	0.213	NA	0.195	7.0e-08	NA	1.8e-10	NA	1.2e-09
2	GTEx	Esophagus Mucosa	0.375	0.0820	1.4e-04	0.254	NA	0.236	NA	0.269	4.7e-17	NA	7.9e-16	NA	4.1e-18
3	GTEx	Testis	0.644	0.0870	2.1e-06	0.049	NA	0.139	NA	0.096	3.2e-03	NA	1.0e-06	NA	4.8e-05
4	GTEx	Whole Blood	0.181	0.0510	1.1e-03	0.028	NA	0.022	NA	0.052	1.2e-03	NA	3.5e-03	NA	1.3e-05
5	METSIM	Adipose	0.133	0.0296	1.9e-08	0.034	0.066	0.074	0.081	0.063	5.9e-06	3.6e-10	2.9e-11	3.8e-12	9.4e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.4	0.7	-0.7	-0.8	-0.8	-0.4	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	-0.0	-0.9	-0.4	0.2	0.5
Depressed Affect (Nagel 2018)	1.3	2.8	6.0	1.3	2.3	2.5	0.1	-1.0
Depression (Nagel 2018)	0.2	0.3	1.0	0.5	1.0	0.2	0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.5	1.4	-0.7	0.6	1.6	-1.4
Neuroticism (Nagel 2018)	1.5	3.6	7.7	1.7	2.8	2.4	1.2	0.4
Schizophrenia (2018)	0.1	0.3	0.4	0.7	-0.5	0.3	0.5	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.3	-0.4	0.5	0.3	0.9
Worry (Nagel 2018)	1.5	3.2	4.4	2.0	2.1	1.5	1.9	1.1
Alzheimer’s Disease (in mother)	0.7	0.9	1.5	0.8	1.1	1.0	1.2	0.2
Alzheimer’s Disease (in father)	2.9	3.1	10.8	-3.3	-1.3	-1.3	-1.1	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-1.0	0.1	-0.2	1.2	0.9
Crohns Disease (2017)	1.1	2.4	6.3	2.5	0.6	-0.9	1.1	1.8
Irritable Bowel Disease (IBD)	0.5	1.2	3.1	1.0	0.1	-0.7	1.2	1.8
Ulcerative Colitis (UC)	0.2	0.4	1.2	-0.6	-0.1	-0.2	0.7	1.1
Major Depression (MDD)	0.2	0.3	0.9	-0.1	-0.2	-0.6	-0.9	0.1
Reaction Time	0.6	1.1	3.7	-1.0	0.5	-0.5	1.9	0.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	5.4	1.9	-0.5	0.7	1.1	-2.3
Breast Cancer	0.1	0.3	1.1	0.7	0.2	-0.3	-1.1	0.2
Ovarian Cancer	1.7	2.2	4.6	0.1	-1.5	0.4	-2.0	-2.2
Prostate Cancer	0.7	0.9	2.3	-0.0	-1.3	1.5	0.9	-0.0
Age at First Birth	0.4	0.7	3.2	-0.0	0.0	-0.0	-0.2	1.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	2.5	-1.0	-1.6	-1.6	-1.0	0.6
Coronary Artery Disease (CAD)	1.0	1.2	4.4	-0.8	-2.1	0.3	-0.3	-0.7
Crohns Disease (2012)	1.8	2.8	4.8	1.6	1.2	-1.3	1.9	2.2
Mean Putamen Volume	0.7	0.8	1.7	-0.6	-1.3	0.5	1.0	0.9
Fasting Glucose	1.1	1.3	5.3	-0.4	-0.9	-0.1	-2.3	0.1
HbA1C	1.4	1.5	4.4	1.3	1.1	0.4	0.1	2.1
HDL Cholesterol	0.5	0.9	3.2	-1.1	-0.0	-0.2	0.0	1.8
LDL Cholesterol	0.4	0.7	1.0	-0.2	-1.0	-0.8	-1.0	-0.8
Lupus	0.9	1.3	2.4	-1.3	0.5	-1.5	-1.3	-0.8
Neuroticism (2016)	0.6	0.9	3.0	-0.5	1.7	-0.3	1.1	0.2
Primary Biliary Cirrhosis	0.9	1.3	3.3	-1.6	-0.1	1.8	-0.7	0.5
Rheumatoid Arthritis	0.3	0.4	0.7	-0.6	-0.7	0.8	-0.4	-0.2
Schizophrenia (2014)	0.1	0.3	1.1	-0.2	-0.2	0.1	-1.1	-0.2
Triglycerides	0.2	0.3	0.6	0.7	-0.5	-0.6	0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	1.1	-0.2	0.8	-0.1	0.6
Ulcerative Colitis	0.3	0.5	1.4	-1.2	0.2	-0.1	0.5	0.9
Blood Eosinophil Count	0.2	1.7	4.2	2.0	0.3	0.3	-0.0	2.0
Blood Platelet Count	0.0	0.1	0.4	0.1	0.0	0.6	0.1	-0.4
Blood Red Count	0.1	0.8	1.8	0.4	-0.6	0.0	-1.2	1.4
Blood White Count	0.4	3.0	9.0	0.1	0.1	-0.1	-2.5	3.0
Heel T-Score	0.1	0.6	1.1	0.3	0.6	0.9	1.1	-0.9
BMI	0.3	1.9	4.1	0.2	1.1	2.0	-1.9	-0.8
Height	0.5	9.5	28.2	-5.3	-0.6	-4.2	0.8	0.9
Waist Hip Ratio (WHR)	0.4	1.6	3.5	-1.8	0.4	-1.1	-1.9	-0.5
Systolic Blood Pressure	0.1	0.6	1.2	-1.1	-0.8	1.0	-0.1	0.5
Smoking Status	0.5	1.3	3.1	-0.9	0.9	-0.5	-1.2	-1.8
Allergy or Eczema	0.3	0.8	1.8	-0.9	-0.7	0.8	1.4	0.2
Cardiovascular Disease	0.1	0.4	1.1	0.4	1.1	0.7	0.0	0.5
Hypothyroidism (self reported)	0.5	1.1	2.6	1.6	0.9	1.2	-0.2	-0.7
Respiratory disease	0.4	0.9	1.8	0.9	1.4	0.3	1.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.7	1.9	0.2	0.1	0.9	-0.7	-1.4
Lung FEV1/FVC ratio	1.1	5.4	18.2	-0.5	-0.1	-2.4	-4.3	1.7
Lung FVC	0.2	1.0	2.8	-0.7	0.7	-1.7	1.1	-0.2
Neuroticism	0.7	1.7	4.5	1.2	2.1	1.3	0.6	0.3
Chronotype (morning person)	0.2	0.4	1.3	0.3	-1.1	0.1	0.9	0.2
Hair Pigment	0.0	0.2	0.5	0.3	-0.4	0.7	-0.1	0.4
Tanning	0.1	1.8	4.4	-1.0	-2.1	-1.6	-0.5	0.8
Hand grip strength (left)	0.2	0.6	1.4	-0.6	0.3	-0.7	-1.2	0.7
Number of treatments/medications taken	0.7	1.3	3.9	-0.3	2.0	-0.8	0.3	1.4
Average weekly spirits intake	0.3	0.4	1.4	0.7	1.2	0.4	0.1	-0.2
Sensitivity / hurt feelings	0.9	1.6	4.1	0.6	2.0	-0.8	1.4	1.0
Frequency of depressed mood in last 2 weeks	1.6	2.3	7.0	1.0	2.6	1.2	1.2	0.6
Hearing difficulty/problems: Yes	0.4	0.6	2.5	0.5	1.6	0.1	0.2	0.5
Relative age of first facial hair	0.1	0.1	0.3	-0.3	-0.2	0.6	0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.1	-0.8	-0.9	-1.1	-0.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.4	1.6	0.7	-0.5	0.5	0.0
Ever had hysterectomy (womb removed)	1.9	2.1	5.6	-2.4	-1.4	-1.4	-0.7	-0.8
Systolic blood pressure, automated reading	0.0	0.1	0.3	-0.3	0.4	0.6	-0.0	-0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.3	0.3	1.8	-0.1	1.6	-1.2
Angina	0.4	0.6	2.1	-0.1	0.5	-0.0	-1.5	-0.7
Medication for hormone replacement therapy	0.9	1.0	3.6	-0.7	-0.3	-1.9	-0.3	0.8
Vitamin and mineral supplements	1.2	1.7	7.5	-0.6	-0.1	-0.6	-0.3	-2.7
Supplements: Zinc	2.0	2.1	6.1	-0.5	1.3	-0.4	2.5	1.6
Medication: Co-codamol	2.0	2.3	4.9	-1.7	-1.7	-2.2	0.4	0.8
Medication: Metformin	0.9	1.3	3.3	-0.2	-1.4	1.8	0.3	-1.1
Diabetes (father)	2.3	2.8	5.9	1.9	1.9	-0.5	2.4	0.9
Diabetes (mother)	1.4	1.8	4.8	0.1	1.1	2.2	-1.6	0.5
Severe depression (siblings)	0.4	0.5	1.3	-0.0	1.1	-1.0	-0.1	-0.3
Pack years adult smoking proportion	0.8	1.2	3.0	-1.7	-0.6	-1.0	0.3	-1.2
Impedance of leg (right)	1.5	7.2	18.1	1.3	2.6	-0.2	4.2	3.0
Leg fat-free mass (left)	0.5	2.9	6.7	-2.0	-0.7	-0.2	-2.6	-1.8
Trunk fat percentage	0.1	0.5	1.8	-0.3	1.3	-0.3	-0.2	-0.7
Hand grip strength (right)	0.3	0.9	2.7	-0.8	0.4	-1.6	-0.8	0.4
Townsend deprivation index at recruitment	0.4	0.5	1.7	-0.6	0.8	-0.2	0.1	-1.3
Current tobacco smoking	0.5	0.9	2.9	-1.0	1.7	-0.6	0.1	-0.3
Average weekly fortified wine intake	0.8	1.0	2.7	-1.3	-1.6	-0.5	-0.3	0.4
Maternal smoking around birth	0.3	0.5	1.2	0.4	1.1	0.8	-0.4	-0.5
Fed-up feelings	1.1	1.9	3.9	1.5	1.8	2.0	0.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	0.3	1.0	0.5	1.2	-0.7
Relative age voice broke	0.7	1.1	2.9	-0.9	-1.4	1.7	-0.3	-0.3
Taking other prescription medications	0.4	0.6	1.6	-0.2	1.3	0.8	0.7	0.6
Age when periods started (menarche)	0.7	1.7	2.2	1.4	1.4	0.2	1.5	1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	-1.0	0.8	-0.3	1.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.8	-0.4	0.2	-1.4	1.7	0.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	-1.0	-0.6	0.2	0.0	-0.5
Qualifications: CSEs or equivalent	2.5	3.3	7.5	2.3	0.4	2.7	-0.3	-1.9
Serious illness, injury or assault to yourself	2.1	2.6	6.3	-0.4	-1.4	1.3	-2.5	-1.7
High blood pressure	0.2	0.7	1.0	-0.2	0.7	1.0	-0.9	-1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.2	-1.1	-0.9	1.1	0.5	0.0
Multivitamins +/- minerals	0.8	1.0	3.3	0.4	-0.4	0.4	-1.1	1.8
Stomach or abdominal pain in last month	0.5	0.6	1.2	0.3	-0.2	1.0	-0.7	-1.1
Supplements: Glucosamine	0.3	0.4	0.7	-0.3	-0.0	-0.8	0.7	0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.1	-0.1	-0.3	0.6	-1.8	-0.5
Medication: Atenolol	0.6	0.8	2.2	0.4	0.6	1.2	0.2	1.5
Medication: Levothyroxine sodium	0.1	0.2	0.7	0.4	0.2	0.2	-0.9	0.4
Sitting height	0.1	0.6	1.8	-0.9	0.0	-0.2	0.4	1.4
Chronic bronchitis/emphysema (father)	1.7	2.0	5.9	-0.7	2.4	-1.7	0.6	-0.4
High blood pressure (mother)	0.9	1.3	3.8	1.3	-0.4	2.0	-0.8	-0.0
Body mass index (BMI)	0.5	2.1	5.4	-0.3	0.7	1.2	-2.3	-1.8
Impedance of leg (left)	1.3	6.4	15.1	0.9	2.2	-1.0	3.9	3.2
Leg predicted mass (left)	0.5	2.9	6.6	-2.0	-0.6	-0.3	-2.6	-1.8
Trunk fat mass	0.2	0.9	1.3	-1.1	1.1	-0.4	-0.9	-0.9
Waist circumference	0.5	1.9	5.3	-1.6	0.9	-0.1	-2.3	-0.9
Number of incorrect matches in round	0.5	0.8	3.0	-0.8	-0.4	-0.1	-1.7	-0.2
Past tobacco smoking	0.3	0.6	1.8	-0.9	-0.4	-0.4	0.0	1.3
Alcohol usually taken with meals	1.6	2.6	4.7	0.5	-2.2	2.0	-1.9	0.7
Nervous feelings	1.1	2.1	3.3	1.8	1.3	1.7	1.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.8	-0.3	1.9	1.7	-0.3	0.0
Hearing difficulty/problems with background noise	1.2	1.9	6.9	0.4	2.6	0.4	1.4	0.4
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	0.7	-0.0	1.0	1.5	-0.0
Had menopause	1.7	2.1	6.9	0.1	0.4	-1.8	0.0	2.6
Had other major operations	0.2	0.3	0.8	0.3	-0.6	0.3	0.9	0.4
Forced vital capacity (FVC)	0.4	1.4	5.0	-1.3	0.1	-2.2	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	-1.2	-0.5	-0.9	1.7	-1.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	-0.4	1.0	-0.4	-0.0	0.0
Qualifications: None of the above	0.5	1.2	2.4	-0.5	1.5	-0.9	-0.0	1.5
Financial difficulties in last 2 years	0.6	0.8	1.8	-0.6	-1.3	-0.4	-1.2	0.3
Mouth/teeth dental problems	0.4	0.7	1.1	-0.8	-0.4	0.8	-0.9	-1.0
Heart attack	1.0	1.2	3.9	-0.5	-1.2	-0.4	-2.0	-0.8
Allergy	0.4	0.9	3.1	0.7	1.8	-0.9	-0.1	0.4
Pain all over the body in last month	0.8	0.9	2.8	0.3	0.7	-0.3	1.7	-0.9
Diabetes (self-reported)	0.8	1.3	4.9	-0.8	-0.2	-0.2	-0.8	-2.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.1	0.7	-0.8	0.5	1.8	1.1
Medication: Ramipril	0.8	1.0	3.3	-1.3	-0.1	-1.8	0.3	0.1
Medication: Simvastatin	1.6	2.3	5.7	0.3	1.7	-1.1	1.3	2.4
Fluid intelligence score	0.5	1.0	1.9	0.5	-1.4	-1.1	-0.8	-0.9
Illnesses of siblings	1.7	2.4	8.7	3.0	-0.2	1.0	1.2	-0.7
Neuroticism score	1.1	2.2	6.0	1.9	2.4	1.2	0.5	0.1
Weight	0.4	2.1	4.5	-2.0	0.7	-0.5	-2.1	-1.1
Impedance of arm (right)	0.7	3.4	11.8	1.4	1.1	-0.6	3.4	1.3
Arm fat percentage (right)	0.3	1.4	3.6	0.3	1.0	1.1	-1.0	-1.9
Trunk fat-free mass	0.7	4.0	10.6	-3.2	-0.4	-1.5	-2.5	-0.7
Hip circumference	0.3	1.2	3.8	-1.2	0.5	0.3	-1.9	-0.7
Time employed in main current job	1.2	1.4	3.5	-1.9	-1.0	0.4	-0.9	-1.3
Alcohol intake versus 10 years previously	0.6	0.9	1.5	0.8	0.5	1.2	-1.2	0.8
Father’s age at death	0.7	0.9	1.4	-0.3	-1.2	-0.9	1.2	0.9
Worrier / anxious feelings	0.9	1.7	3.4	1.5	1.9	-0.4	1.4	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	0.6	1.6	-0.2	0.5	-0.7
Falls in the last year	1.6	2.2	8.7	0.6	-0.8	1.1	-0.3	-2.9
Hair/balding pattern: Pattern 3	1.9	2.8	7.2	-2.7	-1.6	-0.6	-1.7	-0.9
Number of live births	1.4	1.9	3.3	1.5	1.8	-1.2	1.5	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.2	-0.7	-0.2	-1.8	-0.8	0.3
Pulse rate	0.4	0.7	2.3	0.2	0.6	1.5	0.2	-1.0
Happiness	1.1	1.4	5.3	1.0	-0.2	2.3	0.2	-0.7
Noisy workplace	1.0	1.2	2.5	-1.5	-0.2	1.2	1.6	-0.1
Qualifications: A levels/AS levels or equivalent	1.8	3.9	9.2	-2.6	-3.0	-1.2	0.2	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	-1.2	-0.6	-1.1	0.3	-0.8
Mouth/teeth dental problems: Dentures	2.0	3.3	6.6	-0.9	2.0	-2.6	2.2	0.6
Asthma	0.6	1.1	2.6	0.2	-0.8	1.6	1.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.1	1.3	0.6	0.5	2.3	1.7
Medication: Cholesterol lowering	0.5	0.8	1.9	-0.8	1.3	-1.4	-0.3	0.3
Depression (self-reported)	0.8	0.9	4.4	0.3	0.1	2.1	-0.1	-0.3
Medication: Lansoprazole	2.9	3.3	12.3	-1.6	0.4	-3.5	-0.1	-1.2
Prospective memory result	0.4	0.6	1.6	0.1	1.2	-0.1	-0.6	-0.9
Lung cancer (father)	1.2	1.4	3.1	1.8	1.4	-1.0	0.9	0.3
Illnesses of mother	1.3	1.6	3.5	-1.2	-0.7	-1.9	-0.4	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.9	-0.2	-0.3	-1.4	-0.8	0.3
Pulse wave Arterial Stiffness index	2.0	2.4	6.1	-0.2	0.9	0.4	2.5	2.2
Impedance of arm (left)	0.6	3.0	10.4	1.2	0.7	-1.2	3.2	1.2
Arm fat mass (right)	0.4	1.5	3.0	-0.8	0.7	0.7	-1.7	-1.7
Trunk predicted mass	0.7	4.1	10.8	-3.3	-0.4	-1.6	-2.6	-0.6
Standing height	0.6	5.8	13.2	-3.6	0.1	-3.5	0.3	1.7
Length of working week for main job	0.3	0.3	0.9	-0.2	0.0	-0.8	-0.2	-0.9
Exposure to tobacco smoke at home	1.0	1.1	3.5	-1.0	0.5	-1.9	0.9	-0.2
Breastfed as a baby	0.6	0.8	2.1	-0.3	-0.3	-1.4	1.2	0.6
Tense / ‘highly strung’	1.4	2.3	5.7	1.4	2.4	0.9	1.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.1	0.6	0.4	-0.6	-0.1
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.3	0.9	-0.9	0.4	-0.4
Birth weight of first child	0.5	1.0	2.9	-1.7	0.1	-1.3	0.3	-0.5
Peak expiratory flow (PEF)	0.5	1.1	1.8	1.3	-1.0	0.2	-1.0	1.3
Pulse wave reflection index	1.2	1.4	4.7	-0.7	0.5	-0.1	1.3	2.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.9	0.2	1.4	-0.9	-0.6	-0.1
Loud music exposure frequency	0.6	0.7	1.4	-1.2	-1.1	-0.5	0.1	-0.7
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	7.7	-0.4	-2.8	1.1	0.4	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.1	-0.3	0.2	0.3	-0.4	1.5
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.1	-0.6	-1.0	0.7	-0.3
Medication: Paracetamol	0.5	0.8	2.2	0.5	1.5	-0.9	-0.7	-0.3
Headache pain in last month	0.5	0.8	2.6	1.6	0.4	0.1	-0.3	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.5	-0.4	-1.6	0.2	0.1	0.1
Glaucoma (self-reported)	0.6	0.6	1.0	-0.8	-0.2	0.8	-1.0	-0.9
Gout (self-reported)	0.4	0.6	0.9	-0.5	-0.7	-0.9	0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.4	1.2	0.6	0.3	-0.2	-0.7
Medication: Amlodipine	0.7	0.9	2.2	-0.3	-1.2	-0.2	-1.0	-1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.3	1.0	0.2	0.9	-0.1
Birth weight	0.7	1.5	3.4	-0.6	1.8	-1.7	-0.3	1.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.6	1.6	1.2	0.6	1.4	0.6
High blood pressure (siblings)	0.9	1.3	4.7	-2.2	-0.5	-0.1	-1.2	0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	3.1	-1.0	-0.0	-1.8	-0.2	-0.3
Body fat percentage	0.2	0.8	2.9	0.1	1.7	0.3	-0.1	-0.9
Leg fat percentage (right)	0.4	1.3	4.1	0.2	2.0	1.3	0.2	-0.7
Arm fat-free mass (right)	0.6	3.1	7.4	-2.6	-0.1	-1.1	-2.7	-0.1
Exposure to tobacco smoke outside home	1.8	2.4	8.3	1.0	0.4	1.0	-1.1	-2.9
Comparative body size at age 10	1.1	3.2	7.1	-0.3	-1.8	1.0	-2.1	-2.7
Number of full brothers	0.3	0.4	1.0	0.1	0.6	1.0	0.3	-0.8
Worry too long after embarrassment	0.9	1.6	5.0	0.5	2.2	0.4	1.0	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.1	1.2	0.3	0.1	0.0
Wheeze or whistling in the chest in last year	1.5	2.6	6.6	0.9	2.6	-0.7	2.2	0.8
Number of children fathered	1.5	1.6	4.3	1.2	-0.2	-0.8	1.3	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.4	1.0	-0.6	-0.8	0.1
Age at first live birth	0.6	1.0	1.8	-1.3	-1.4	-0.2	-0.9	-0.9
Pulse wave peak to peak time	1.9	2.2	6.0	0.2	-0.9	-0.3	-2.4	-2.0
Health satisfaction	0.2	0.3	0.8	0.2	-0.4	0.8	-0.9	0.2
Shortness of breath walking on level ground	1.2	1.4	3.5	0.7	-0.6	1.9	-0.7	-1.5
Qualifications: College or University degree	1.1	3.3	6.8	-2.2	-2.6	-0.4	-0.9	-2.0
Eye problems/disorders: None of the above	0.6	0.7	2.0	-0.7	-1.4	-0.1	-0.9	0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	0.7	0.1	1.3	-1.0	0.5
Emphysema/chronic bronchitis	0.5	0.5	1.9	0.8	-0.2	-0.1	-1.4	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.3	-0.6	0.7	0.3	-0.8
Neck or shoulder pain in last month	0.3	0.4	0.8	0.3	0.6	0.8	-0.2	-0.9
Medication: Blood pressure	0.3	0.6	1.2	1.1	1.0	0.7	-0.0	-0.4
Angina (self-reported)	0.3	0.4	1.4	0.3	0.7	0.2	-1.2	-0.2
Migraine (self-reported)	0.9	1.1	4.5	0.6	-0.5	-0.7	0.0	2.1
Medication: Ibuprofen	1.5	1.8	3.9	1.2	0.6	0.3	1.8	2.0
Medication: Allopurinol	0.3	0.4	1.1	0.5	-0.0	0.5	1.1	0.5
Medication: Omeprazole	0.6	0.7	2.5	1.6	0.5	0.7	0.4	-0.2
Medication: Seretide 50 evohaler	0.5	0.6	1.8	0.9	-0.5	1.4	0.3	-0.1
Mean time to correctly identify matches	1.0	1.9	4.8	-0.5	1.1	-0.6	2.2	1.7
Heart disease (mother)	1.0	1.2	4.0	-0.9	-0.6	-0.9	-2.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.2	0.1	0.9	-0.8	1.5	0.5
Whole body fat mass	0.2	0.9	1.4	-0.7	1.2	0.3	-1.0	-1.2
Leg fat mass (right)	0.3	1.0	1.9	-0.8	1.4	0.9	-0.8	-1.0
Arm predicted mass (right)	0.6	3.1	7.5	-2.7	-0.0	-1.2	-2.5	-0.3
Pulse rate, automated reading	0.3	0.8	3.0	0.2	1.7	0.6	-0.2	-0.9
Alcohol intake frequency.	0.2	0.4	0.7	-0.4	0.8	0.0	-0.7	0.7
Comparative height size at age 10	0.7	3.8	9.7	-3.1	0.5	-2.6	1.5	0.4
Number of full sisters	0.7	0.8	1.7	1.1	-1.3	1.1	-0.1	0.5
Suffer from ‘nerves’	1.8	2.9	5.8	2.0	1.2	2.4	0.7	1.6
Overall health rating	0.5	1.0	2.9	0.7	1.7	-0.7	-0.5	-0.9
Chest pain or discomfort	1.3	1.9	5.1	1.2	1.5	0.7	2.3	0.4
Had major operations	0.4	0.4	1.1	0.2	0.3	-0.9	1.1	-0.5
Age at last live birth	0.3	0.4	0.7	-0.8	-0.7	0.8	-0.5	-0.2
Family relationship satisfaction	1.0	1.3	4.4	0.2	-1.0	2.1	-0.9	-0.5
Leg pain on walking	0.9	1.2	2.2	-1.3	-1.4	-0.2	-1.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	1.1	0.1	0.7	-0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.1	0.1	-0.4	0.3	-1.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.9	0.4	1.1	-0.1	2.0	0.0
Medication: Aspirin	0.3	0.4	0.9	-0.8	-0.3	0.1	-1.0	0.2
Supplements: Vitamin C	0.9	1.0	1.7	-1.0	-0.6	-1.3	1.0	1.1
Knee pain experienced in last month	0.8	1.2	3.1	1.1	1.1	1.8	-0.1	-0.5
Hypertension (Self-reported)	0.2	0.7	1.5	-0.4	0.8	0.4	-1.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.9	2.6	1.3	0.5	1.1	0.5
Illnesses of father: Heart disease	2.0	2.7	6.1	2.2	1.3	2.5	-1.0	0.3
Illnesses of siblings: Diabetes	1.7	2.1	4.0	1.1	1.6	0.0	1.6	2.0
Smoking status: Previous	0.3	0.5	1.1	1.1	0.2	0.6	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	4.2	-2.0	-0.6	-1.3	-1.0	0.1
Whole body fat-free mass	0.6	3.6	8.1	-2.9	-0.5	-1.0	-2.7	-1.1
Leg fat-free mass (right)	0.6	3.4	8.4	-2.1	-0.9	-0.4	-2.9	-1.7
Arm fat percentage (left)	0.3	1.0	2.8	0.1	0.8	0.7	-1.1	-1.7
Average weekly red wine intake	0.9	1.4	4.2	-0.3	-2.1	0.1	-1.6	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.9	-0.1	0.2	-0.1	1.0
Mood swings	1.7	3.0	9.7	1.2	3.1	1.1	-1.3	-1.1
Loneliness, isolation	1.1	1.6	3.2	1.0	1.6	0.9	1.8	-0.6
Long-standing illness, disability or infirmity	0.3	0.5	0.8	-0.1	0.9	-0.6	0.9	0.5
Ever had bowel cancer screening	0.3	0.4	0.9	0.7	0.2	-0.3	0.9	0.8
Diabetes diagnosed by doctor	0.4	0.6	1.8	-0.6	0.2	0.1	-0.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.6	0.6	0.1	-0.5	0.4
Friendships satisfaction	0.3	0.4	0.7	0.5	-0.5	0.9	0.8	-0.1
Qualifications: nursing, teaching	2.0	3.1	10.3	-0.5	-2.0	-0.3	-0.9	-3.2
Commuting to job workplace: Walk	0.4	0.4	0.9	0.1	0.7	-0.3	1.0	0.8
Eye problems/disorders: Cataract	1.8	2.1	4.4	0.1	2.1	-1.0	1.4	1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.2	2.3	-0.4	0.7	0.2	1.5
Medication for cholesterol	1.5	2.3	5.4	2.3	0.4	2.1	0.8	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.0	0.0	0.5	0.2	-0.3
Back pain experienced in last month	0.7	1.0	1.7	1.2	0.6	0.9	1.3	0.6
Mineral and other dietary supplements	0.9	1.2	3.2	0.8	-1.3	-0.3	-0.6	-1.8
Breast cancer (self-reported)	0.9	1.1	4.8	-0.1	2.2	-0.6	-0.1	-0.6
Asthma (self-reported)	0.6	1.2	2.4	0.3	-0.6	1.6	1.2	-1.2
Osteoporosis (self-reported)	0.5	0.7	1.6	0.0	-0.2	1.2	1.3	0.4
Osteoarthritis (self-reported)	0.4	0.5	1.5	1.2	-0.2	0.7	0.6	-0.0
Medication: Aspirin	0.4	0.6	1.3	-1.1	-0.2	-0.6	-0.9	0.5
Medication: Gliclazide	0.2	0.3	0.6	0.4	-0.2	-0.6	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	0.4	-1.0	0.4	0.6	0.1
Smoking status: Current	0.4	0.6	1.3	-1.0	1.1	-0.3	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.3	0.6	-0.1	-1.4	-1.5	0.7
Whole body water mass	0.7	3.7	8.3	-2.9	-0.6	-1.0	-2.8	-1.0
Leg predicted mass (right)	0.7	3.6	8.9	-2.2	-1.1	-0.4	-3.0	-1.7
Arm fat mass (left)	0.3	1.4	3.5	-0.9	0.7	0.1	-1.9	-1.5
Number of self-reported non-cancer illnesses	0.8	1.4	2.8	1.2	1.0	1.7	1.2	0.1
Average weekly champagne plus white wine intake	0.6	0.8	1.8	-0.5	-0.1	1.4	0.3	1.3
Miserableness	1.5	2.6	7.5	0.7	2.7	2.1	0.7	0.2
Guilty feelings	0.7	1.1	3.8	0.3	-0.3	1.9	-0.3	-1.1
Wears glasses or contact lenses	2.8	3.2	7.0	0.5	1.0	-2.0	1.9	2.6
Ever taken oral contraceptive pill	0.6	0.7	1.8	1.1	0.6	0.4	1.3	-0.1
Hearing aid user	0.4	0.4	0.9	0.9	0.9	-0.3	0.5	0.2
Mother’s age at death	1.6	2.0	3.5	1.9	0.1	1.8	1.8	-0.2
Financial situation satisfaction	0.3	0.4	1.1	0.8	-0.1	0.2	-0.4	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.9	0.9	0.6	-0.3	-0.7
Commuting to job workplace: Public transport	0.8	0.9	2.5	-0.5	1.6	0.0	1.3	-0.1
Eye problems/disorders: Glaucoma	1.1	1.3	2.8	-1.0	-0.4	1.7	-0.6	-1.5
Medication: Blood pressure	0.7	1.3	2.3	-1.4	-0.8	-0.6	-1.5	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	-0.1	0.6	-0.5	-0.6	-0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.8	-1.4	1.2	0.5	0.1	1.7
High cholesterol (Self-reported)	0.5	0.9	1.5	-1.0	0.6	-1.2	0.6	1.1
Medication: Bendroflumethiazide	0.4	0.7	1.7	-1.3	-0.2	-1.1	-0.2	0.7
Medication: Paracetamol	0.9	1.3	3.6	0.9	1.9	-1.1	-0.9	0.3
Medication: Lisinopril	0.5	0.6	2.6	0.1	-0.2	-1.6	-0.6	-0.2
Medication: Atorvastatin	0.4	0.5	1.3	-0.8	-1.1	-0.1	-0.6	-0.1
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.3	0.8	0.7	-0.3	0.3
Alcohol drinker status: Never	0.1	0.1	0.3	0.2	0.2	0.6	-0.2	-0.5
Ever smoked	0.4	0.7	3.2	-0.1	0.6	0.2	-0.1	-1.8
Basal metabolic rate	0.6	3.3	7.2	-2.7	-0.3	-0.8	-2.7	-1.2
Leg fat percentage (left)	0.2	0.8	2.9	0.1	1.7	0.8	-0.2	-0.7
Arm fat-free mass (left)	0.6	2.9	7.0	-2.5	0.1	-0.8	-2.6	-0.5
Number of operations (self-reported)	0.2	0.4	1.5	-0.2	-0.3	-0.1	1.2	-0.4
Average weekly beer plus cider intake	1.0	1.5	5.0	1.1	2.2	0.7	0.5	-0.8
Irritability	1.0	1.7	4.6	1.1	2.1	1.5	0.7	0.3
Risk taking	0.6	0.9	2.9	-1.7	0.6	-0.5	-0.6	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-1.0	-0.2	-0.1	0.4	0.7
Fractured/broken bones in last 5 years	0.3	0.4	1.5	-1.2	-0.2	-0.2	-0.2	-0.6
Age started oral contraceptive pill	0.9	1.2	3.1	-0.2	0.5	-1.1	1.1	1.8
Diastolic blood pressure, automated reading	0.3	1.1	2.9	-0.8	1.7	0.8	0.8	-0.8
Ever depressed for a whole week	0.5	0.6	0.9	0.7	0.6	-1.0	0.8	0.6
Unable to work because of sickness or disability	3.2	4.1	5.7	2.2	1.9	2.4	2.3	-1.0
Commuting to job workplace: Cycle	0.6	0.8	1.1	-1.0	-1.1	1.0	-0.8	-0.2
Myopia	2.1	3.0	9.6	1.7	-1.2	3.1	1.1	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.1	0.3	-0.8	-0.7	1.0	1.1
Cholesterol lowering medication	0.1	0.1	0.2	-0.5	-0.4	0.4	-0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.0	1.7	1.1	-0.1	1.2	0.3
Pain experienced in last month	0.6	1.1	3.7	-1.9	-0.7	-0.8	-0.4	0.6
Supplements: Calcium	0.6	0.6	2.0	0.1	-0.8	1.4	-0.5	0.5
Basal cell carcinoma (self-reported)	0.9	1.1	1.6	-1.3	-0.6	-1.2	0.9	-1.1
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.8	-0.8	-1.2	-0.6	-2.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-0.1	-0.8	-0.8	0.9	-0.3
Heart disease (siblings)	0.4	0.5	1.7	-1.3	0.4	0.0	0.4	-0.6
Alcohol drinker status: Previous	0.0	0.1	0.1	0.1	0.3	0.1	0.4	0.2
Pack years of smoking	0.9	1.3	2.7	-1.7	-0.6	-1.3	0.7	-1.2
Impedance of whole body	1.0	5.0	15.1	1.3	1.4	-0.8	3.9	2.3
Leg fat mass (left)	0.2	0.9	1.3	-0.7	1.1	0.6	-1.1	-1.0
Arm predicted mass (left)	0.5	2.8	6.7	-2.5	0.4	-1.0	-2.6	-0.3